Results of Job: search_13be8c4c-531f-40ce-a515-72b1e3321795

Query Target Key Target Name Description P-Value MaxTC

Dacomitinib

EGFR_HUMAN EGFR Epidermal growth factor receptor 0 1.00
ERBB2_HUMAN ERBB2 Receptor tyrosine-protein kinase erbB-2 2.298e-286 1.00
ERBB4_HUMAN ERBB4 Receptor tyrosine-protein kinase erbB-4 1.415e-198 1.00
SRC_HUMAN SRC Proto-oncogene tyrosine-protein kinase Src 1.652e-35 1.00
LCK_HUMAN LCK Tyrosine-protein kinase Lck 7.472e-14 1.00
JAK3_HUMAN JAK3 Tyrosine-protein kinase JAK3 1.317e-13 1.00
EPHA2_HUMAN EPHA2 Ephrin type-A receptor 2 1.934e-291 0.54
EPHB4_HUMAN EPHB4 Ephrin type-B receptor 4 6.042e-235 0.57
VGFR2_HUMAN KDR Vascular endothelial growth factor receptor 2 6.302e-142 0.59
PGFRB_HUMAN PDGFRB Platelet-derived growth factor receptor beta 4.515e-99 0.62
DUS2L_HUMAN DUS2 tRNA-dihydrouridine(20) synthase [NAD(P)+]-like 1.448e-86 0.69
F16P1_PIG FBP1 Fructose-1,6-bisphosphatase 1 1.297e-66 0.57
ERBB3_HUMAN ERBB3 Receptor tyrosine-protein kinase erbB-3 1.354e-65 0.69
TBA1A_RAT Tuba1a Tubulin alpha-1A chain 3.89e-65 0.53
ERBB2_RAT Erbb2 Receptor tyrosine-protein kinase erbB-2 8.325e-60 0.38
RET_HUMAN RET Proto-oncogene tyrosine-protein kinase receptor Ret 1.79e-57 0.56
BRAF_HUMAN BRAF Serine/threonine-protein kinase B-raf 5.925e-57 0.53
VGFR1_HUMAN FLT1 Vascular endothelial growth factor receptor 1 1.316e-56 0.56
ULK3_MOUSE Ulk3 Serine/threonine-protein kinase ULK3 1.972e-52 0.53
CCR4_MOUSE Ccr4 C-C chemokine receptor type 4 1.278e-50 0.36
MELK_HUMAN MELK Maternal embryonic leucine zipper kinase 6.67e-50 0.38
MET_HUMAN MET Hepatocyte growth factor receptor 2.219e-49 0.60
STK10_HUMAN STK10 Serine/threonine-protein kinase 10 3.093e-41 0.60
MP2K5_HUMAN MAP2K5 Dual specificity mitogen-activated protein kinase kinase 5 1.738e-40 0.60
MK04_HUMAN MAPK4 Mitogen-activated protein kinase 4 2.293e-38 0.53
EPHA6_HUMAN EPHA6 Ephrin type-A receptor 6 5.916e-38 0.60
EPHB6_HUMAN EPHB6 Ephrin type-B receptor 6 3.732e-37 0.60
CTRO_HUMAN CIT Citron Rho-interacting kinase 2.111e-36 0.60
STK36_HUMAN STK36 Serine/threonine-protein kinase 36 2.609e-36 0.53
AURKA_HUMAN AURKA Aurora kinase A 3.878e-36 0.57
KMT5A_HUMAN KMT5A N-lysine methyltransferase KMT5A 1.401e-35 0.29
EPHA8_HUMAN EPHA8 Ephrin type-A receptor 8 1.141e-34 0.53
M3K4_HUMAN MAP3K4 Mitogen-activated protein kinase kinase kinase 4 2.566e-33 0.48
HNMT_RAT Hnmt Histamine N-methyltransferase 3.701e-33 0.32
PHKG1_HUMAN PHKG1 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 1.779e-32 0.60
EPHA5_HUMAN EPHA5 Ephrin type-A receptor 5 4.169e-32 0.53
EPHB1_HUMAN EPHB1 Ephrin type-B receptor 1 8.981e-32 0.53
CSK_HUMAN CSK Tyrosine-protein kinase CSK 1.452e-31 0.48
PGFRA_HUMAN PDGFRA Platelet-derived growth factor receptor alpha 2.448e-31 0.62
TXK_HUMAN TXK Tyrosine-protein kinase TXK 2.592e-31 0.60
SIK2_HUMAN SIK2 Serine/threonine-protein kinase SIK2 3.47e-31 0.53
WEE2_HUMAN WEE2 Wee1-like protein kinase 2 7.081e-31 0.48
AURKB_HUMAN AURKB Aurora kinase B 1.089e-29 0.57
VGFR3_HUMAN FLT4 Vascular endothelial growth factor receptor 3 1.44e-29 0.57
SBK1_HUMAN SBK1 Serine/threonine-protein kinase SBK1 2.834e-29 0.60
TIE2_HUMAN TEK Angiopoietin-1 receptor 1.266e-28 0.57
TIE1_HUMAN TIE1 Tyrosine-protein kinase receptor Tie-1 8.933e-28 0.48
STK35_HUMAN STK35 Serine/threonine-protein kinase 35 2.154e-27 0.38
M4K3_HUMAN MAP4K3 Mitogen-activated protein kinase kinase kinase kinase 3 3.798e-27 0.48
COQ8B_HUMAN COQ8B Atypical kinase COQ8B, mitochondrial 4.483e-27 0.48
ENL_HUMAN MLLT1 Protein ENL 5.245e-27 0.33
RIPK2_HUMAN RIPK2 Receptor-interacting serine/threonine-protein kinase 2 7.801e-27 0.60
M4K1_HUMAN MAP4K1 Mitogen-activated protein kinase kinase kinase kinase 1 3.84e-26 0.48
MK06_HUMAN MAPK6 Mitogen-activated protein kinase 6 1.197e-25 0.53
M3K3_HUMAN MAP3K3 Mitogen-activated protein kinase kinase kinase 3 1.285e-25 0.53
M3K8_HUMAN MAP3K8 Mitogen-activated protein kinase kinase kinase 8 2.008e-25 0.35
M3K19_HUMAN MAP3K19 Mitogen-activated protein kinase kinase kinase 19 2.1e-25 0.53
DMPK_HUMAN DMPK Myotonin-protein kinase 2.575e-25 0.53
EPHA3_HUMAN EPHA3 Ephrin type-A receptor 3 3.565e-25 0.53
PDE5A_BOVIN PDE5A cGMP-specific 3',5'-cyclic phosphodiesterase 4.586e-25 0.37
RAF1_HUMAN RAF1 RAF proto-oncogene serine/threonine-protein kinase 5.817e-25 0.48
STK4_HUMAN STK4 Serine/threonine-protein kinase 4 6.947e-25 0.48
GAK_HUMAN GAK Cyclin-G-associated kinase 7.295e-25 0.60
ABL2_HUMAN ABL2 Tyrosine-protein kinase ABL2 7.31e-25 0.53
CSF1R_HUMAN CSF1R Macrophage colony-stimulating factor 1 receptor 7.871e-25 0.48
MYLK2_HUMAN MYLK2 Myosin light chain kinase 2, skeletal/cardiac muscle 1.042e-24 0.53
AUKBA_XENLA aurkb-a Aurora kinase B-A 1.569e-24 0.39
ST32B_HUMAN STK32B Serine/threonine-protein kinase 32B 2.58e-24 0.48
MRCKG_HUMAN CDC42BPG Serine/threonine-protein kinase MRCK gamma 5.654e-24 0.38
E2AK3_HUMAN EIF2AK3 Eukaryotic translation initiation factor 2-alpha kinase 3 6.131e-24 0.45
MALT1_HUMAN MALT1 Mucosa-associated lymphoid tissue lymphoma translocation protein 1 1.528e-23 0.34
STK25_HUMAN STK25 Serine/threonine-protein kinase 25 1.802e-23 0.48
M3K2_HUMAN MAP3K2 Mitogen-activated protein kinase kinase kinase 2 3.86e-23 0.53
FGR_HUMAN FGR Tyrosine-protein kinase Fgr 4.761e-23 0.53
STK24_HUMAN STK24 Serine/threonine-protein kinase 24 6.553e-23 0.48
ENV_HV1Y2 env Envelope glycoprotein gp160 1.014e-22 0.31
LRRK2_HUMAN LRRK2 Leucine-rich repeat serine/threonine-protein kinase 2 4.97e-22 0.38
CDK16_HUMAN CDK16 Cyclin-dependent kinase 16 7.671e-22 0.48
EPHA1_HUMAN EPHA1 Ephrin type-A receptor 1 9.007e-22 0.53
NUAK2_HUMAN NUAK2 NUAK family SNF1-like kinase 2 1.055e-21 0.53
STK3_MOUSE Stk3 Serine/threonine-protein kinase 3 1.98e-21 0.48
EPHB2_HUMAN EPHB2 Ephrin type-B receptor 2 9.738e-21 0.43
HUNK_HUMAN HUNK Hormonally up-regulated neu tumor-associated kinase 1.004e-20 0.38
ULK3_HUMAN ULK3 Serine/threonine-protein kinase ULK3 1.127e-20 0.38
KIT_HUMAN KIT Mast/stem cell growth factor receptor Kit 1.641e-20 0.58
C3SLB7_ECOLX glmU Bifunctional protein GlmU 3.004e-20 0.38
INSR_HUMAN INSR Insulin receptor 6.959e-20 0.60
SMN_HUMAN SMN1; SMN2 Survival motor neuron protein 7.617e-20 0.29
RIPK4_HUMAN RIPK4 Receptor-interacting serine/threonine-protein kinase 4 1.683e-19 0.38
DCLK3_HUMAN DCLK3 Serine/threonine-protein kinase DCLK3 3.223e-19 0.53
ETHR_MYCS2 ethR HTH-type transcriptional regulator EthR 3.251e-19 0.31
STK33_HUMAN STK33 Serine/threonine-protein kinase 33 3.917e-19 0.48
PMYT1_HUMAN PKMYT1 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase 4.695e-19 0.48
EPHA7_HUMAN EPHA7 Ephrin type-A receptor 7 6.237e-19 0.38
SPTC2_HUMAN SPTLC2 Serine palmitoyltransferase 2 6.741e-19 0.30
PDE6A_BOVIN PDE6A Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha 7.376e-19 0.29
FGFR1_HUMAN FGFR1 Fibroblast growth factor receptor 1 1.112e-18 0.56
KC1AL_HUMAN CSNK1A1L Casein kinase I isoform alpha-like 2.173e-18 0.48
TNI3K_HUMAN TNNI3K Serine/threonine-protein kinase TNNI3K 2.595e-18 0.48
COQ8A_HUMAN COQ8A Atypical kinase COQ8A, mitochondrial 3.013e-18 0.38
ASF1A_HUMAN ASF1A Histone chaperone ASF1A 3.244e-18 0.29
FLT3_HUMAN FLT3 Receptor-type tyrosine-protein kinase FLT3 3.826e-18 0.62
SIK1_HUMAN SIK1 Serine/threonine-protein kinase SIK1 4.287e-18 0.38
CCR1_MOUSE Ccr1 C-C chemokine receptor type 1 4.303e-18 0.31
RON_HUMAN MST1R Macrophage-stimulating protein receptor 7.172e-18 0.56
IRAK3_HUMAN IRAK3 Interleukin-1 receptor-associated kinase 3 1.881e-17 0.53
DUSTY_HUMAN DSTYK Dual serine/threonine and tyrosine protein kinase 2.479e-17 0.38
KS6A6_HUMAN RPS6KA6 Ribosomal protein S6 kinase alpha-6 3.1e-17 0.60
FGFR4_HUMAN FGFR4 Fibroblast growth factor receptor 4 3.81e-17 0.38
5HT4R_RAT Htr4 5-hydroxytryptamine receptor 4 1.11e-16 0.38
FYN_HUMAN FYN Tyrosine-protein kinase Fyn 1.11e-16 0.48
LUCI_RENRE Coelenterazine h 2-monooxygenase 1.11e-16 0.32
M3K13_HUMAN MAP3K13 Mitogen-activated protein kinase kinase kinase 13 1.11e-16 0.38
MAST1_HUMAN MAST1 Microtubule-associated serine/threonine-protein kinase 1 1.11e-16 0.38
UFO_HUMAN AXL Tyrosine-protein kinase receptor UFO 1.11e-16 0.60
MCHR1_HUMAN MCHR1 Melanin-concentrating hormone receptor 1 2.22e-16 0.35
ST17B_HUMAN STK17B Serine/threonine-protein kinase 17B 3.331e-16 0.53
MRCKB_HUMAN CDC42BPB Serine/threonine-protein kinase MRCK beta 4.441e-16 0.38
ST32A_HUMAN STK32A Serine/threonine-protein kinase 32A 4.441e-16 0.38
CD38_MOUSE Cd38 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 7.772e-16 0.40
CCR4_HUMAN CCR4 C-C chemokine receptor type 4 1.221e-15 0.39
TNIK_HUMAN TNIK TRAF2 and NCK-interacting protein kinase 1.887e-15 0.53
SIK3_HUMAN SIK3 Serine/threonine-protein kinase SIK3 2.442e-15 0.38
BMP2K_HUMAN BMP2K BMP-2-inducible protein kinase 3.886e-15 0.48
BLK_MOUSE Blk Tyrosine-protein kinase Blk 4.441e-15 0.29
MYO3A_HUMAN MYO3A Myosin-IIIa 1.077e-14 0.29
E2AK4_HUMAN EIF2AK4 eIF-2-alpha kinase GCN2 1.155e-14 0.48
CPT2_RAT Cpt2 Carnitine O-palmitoyltransferase 2, mitochondrial 1.41e-14 0.30
NLK_HUMAN NLK Serine/threonine-protein kinase NLK 2.986e-14 0.53
FGFR2_HUMAN FGFR2 Fibroblast growth factor receptor 2 3.353e-14 0.45
YES_HUMAN YES1 Tyrosine-protein kinase Yes 3.797e-14 0.48
ALK_HUMAN ALK ALK tyrosine kinase receptor 5.496e-14 0.48
MYO3B_HUMAN MYO3B Myosin-IIIb 5.618e-14 0.29
NEK3_HUMAN NEK3 Serine/threonine-protein kinase Nek3 5.618e-14 0.38
CD38_HUMAN CD38 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 6.384e-14 0.40
ST38L_HUMAN STK38L Serine/threonine-protein kinase 38-like 7.028e-14 0.48
EHMT2_HUMAN EHMT2 Histone-lysine N-methyltransferase EHMT2 8.56e-14 0.31
MP2K2_HUMAN MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 1.407e-13 0.48
ABCG2_HUMAN ABCG2 Broad substrate specificity ATP-binding cassette transporter ABCG2 1.541e-13 0.53
PHKG2_HUMAN PHKG2 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 1.594e-13 0.60
LYN_HUMAN LYN Tyrosine-protein kinase Lyn 2.658e-13 0.53
SLK_HUMAN SLK STE20-like serine/threonine-protein kinase 2.681e-13 0.60
PDE3B_HUMAN PDE3B cGMP-inhibited 3',5'-cyclic phosphodiesterase B 3.495e-13 0.32
BLK_HUMAN BLK Tyrosine-protein kinase Blk 3.806e-13 0.60
VRK2_HUMAN VRK2 Serine/threonine-protein kinase VRK2 3.922e-13 0.29
ABL1_MOUSE Abl1 Tyrosine-protein kinase ABL1 4.392e-13 0.30
RET4_HUMAN RBP4 Retinol-binding protein 4 4.821e-13 0.33
O77823_PIG PDE4A Cyclic AMP-specific phosphodiesterase SSPDE4A1A 5.118e-13 0.31
HDAC3_HUMAN HDAC3 Histone deacetylase 3 8.227e-13 0.39
FA11_HUMAN F11 Coagulation factor XI 8.763e-13 0.30
INSRR_HUMAN INSRR Insulin receptor-related protein 9.3e-13 0.38
MP2K1_HUMAN MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 1.052e-12 0.48
EPHA4_HUMAN EPHA4 Ephrin type-A receptor 4 1.311e-12 0.38
STK26_HUMAN STK26 Serine/threonine-protein kinase 26 1.463e-12 0.38
KKCC1_HUMAN CAMKK1 Calcium/calmodulin-dependent protein kinase kinase 1 1.544e-12 0.48
AAK1_HUMAN AAK1 AP2-associated protein kinase 1 2.566e-12 0.48
TESK1_HUMAN TESK1 Dual specificity testis-specific protein kinase 1 2.659e-12 0.38
CDK15_HUMAN CDK15 Cyclin-dependent kinase 15 2.774e-12 0.29
TAOK2_HUMAN TAOK2 Serine/threonine-protein kinase TAO2 4.405e-12 0.30
F16P1_HUMAN FBP1 Fructose-1,6-bisphosphatase 1 4.685e-12 0.57
P2RX3_HUMAN P2RX3 P2X purinoceptor 3 4.856e-12 0.31
DDR1_HUMAN DDR1 Epithelial discoidin domain-containing receptor 1 5.27e-12 0.38
PDE3A_HUMAN PDE3A cGMP-inhibited 3',5'-cyclic phosphodiesterase A 6.644e-12 0.32
IGF1R_HUMAN IGF1R Insulin-like growth factor 1 receptor 8.034e-12 0.60
FRK_HUMAN FRK Tyrosine-protein kinase FRK 8.713e-12 0.60
AURKC_HUMAN AURKC Aurora kinase C 1.602e-11 0.38
CLK1_MOUSE Clk1 Dual specificity protein kinase CLK1 3.126e-11 0.35
CDKL2_HUMAN CDKL2 Cyclin-dependent kinase-like 2 6.81e-11 0.35
HDAC6_HUMAN HDAC6 Histone deacetylase 6 7.734e-11 0.43
MKNK1_HUMAN MKNK1 MAP kinase-interacting serine/threonine-protein kinase 1 8.364e-11 0.60
LTK_HUMAN LTK Leukocyte tyrosine kinase receptor 9.763e-11 0.53
CDK14_HUMAN CDK14 Cyclin-dependent kinase 14 1.066e-10 0.29
CCNA1_HUMAN CCNA1 Cyclin-A1 1.207e-10 0.35
DYR1A_HUMAN DYRK1A Dual specificity tyrosine-phosphorylation-regulated kinase 1A 1.211e-10 0.60
E2AK1_HUMAN EIF2AK1 Eukaryotic translation initiation factor 2-alpha kinase 1 1.218e-10 0.30
PDE11_HUMAN PDE11A Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A 1.27e-10 0.31
CPT2_HUMAN CPT2 Carnitine O-palmitoyltransferase 2, mitochondrial 2.135e-10 0.30
DDR2_HUMAN DDR2 Discoidin domain-containing receptor 2 2.208e-10 0.38
M3K9_HUMAN MAP3K9 Mitogen-activated protein kinase kinase kinase 9 3.187e-10 0.38
KKCC2_HUMAN CAMKK2 Calcium/calmodulin-dependent protein kinase kinase 2 3.49e-10 0.48
KCC1D_HUMAN CAMK1D Calcium/calmodulin-dependent protein kinase type 1D 3.596e-10 0.48
SRPK3_HUMAN SRPK3 SRSF protein kinase 3 3.862e-10 0.34
ANKK1_HUMAN ANKK1 Ankyrin repeat and protein kinase domain-containing protein 1 4.352e-10 0.29
MEP2_YEAST MEP2 Ammonium transporter MEP2 5.866e-10 0.29
MERTK_HUMAN MERTK Tyrosine-protein kinase Mer 5.999e-10 0.48
PI42C_HUMAN PIP4K2C Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma 6.204e-10 0.53
GRK4_HUMAN GRK4 G protein-coupled receptor kinase 4 6.75e-10 0.34
CDKL3_HUMAN CDKL3 Cyclin-dependent kinase-like 3 6.847e-10 0.29
NEK11_HUMAN NEK11 Serine/threonine-protein kinase Nek11 7.541e-10 0.29
CPT1A_HUMAN CPT1A Carnitine O-palmitoyltransferase 1, liver isoform 8.155e-10 0.31
MKNK2_HUMAN MKNK2 MAP kinase-interacting serine/threonine-protein kinase 2 8.158e-10 0.60
HIPK4_HUMAN HIPK4 Homeodomain-interacting protein kinase 4 8.327e-10 0.60
HDAC1_HUMAN HDAC1 Histone deacetylase 1 1.021e-09 0.43
CLK3_HUMAN CLK3 Dual specificity protein kinase CLK3 1.066e-09 0.48
FES_HUMAN FES Tyrosine-protein kinase Fes/Fps 1.293e-09 0.48
KC1E_HUMAN CSNK1E Casein kinase I isoform epsilon 1.336e-09 0.60
BMX_HUMAN BMX Cytoplasmic tyrosine-protein kinase BMX 1.46e-09 0.48
ABL1_HUMAN ABL1 Tyrosine-protein kinase ABL1 1.509e-09 0.62
M4K5_HUMAN MAP4K5 Mitogen-activated protein kinase kinase kinase kinase 5 1.558e-09 0.53
HCK_HUMAN HCK Tyrosine-protein kinase HCK 1.69e-09 0.60
KLKB1_HUMAN KLKB1 Plasma kallikrein 1.71e-09 0.30
TNK1_HUMAN TNK1 Non-receptor tyrosine-protein kinase TNK1 1.79e-09 0.34
CPT1B_HUMAN CPT1B Carnitine O-palmitoyltransferase 1, muscle isoform 2.18e-09 0.30
CPT1A_RAT Cpt1a Carnitine O-palmitoyltransferase 1, liver isoform 2.551e-09 0.31
DYR1B_HUMAN DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B 2.83e-09 0.60
T23O_HUMAN TDO2 Tryptophan 2,3-dioxygenase 3.065e-09 0.32
MAK_HUMAN MAK Serine/threonine-protein kinase MAK 3.29e-09 0.29
KS6A4_HUMAN RPS6KA4 Ribosomal protein S6 kinase alpha-4 4.429e-09 0.53
PI42B_HUMAN PIP4K2B Phosphatidylinositol 5-phosphate 4-kinase type-2 beta 4.712e-09 0.48
CSK21_HUMAN CSNK2A1 Casein kinase II subunit alpha 5.093e-09 0.38
SRC_CHICK SRC Proto-oncogene tyrosine-protein kinase Src 5.561e-09 0.38
IRAK1_HUMAN IRAK1 Interleukin-1 receptor-associated kinase 1 5.744e-09 0.60
DLDH_MYCTU lpdC Dihydrolipoyl dehydrogenase 6.356e-09 0.33
KS6B1_HUMAN RPS6KB1 Ribosomal protein S6 kinase beta-1 6.515e-09 0.38
ACES_ANOGA Ace Acetylcholinesterase 6.816e-09 0.33
PAK2_HUMAN PAK2 Serine/threonine-protein kinase PAK 2 7.006e-09 0.38
M3K11_HUMAN MAP3K11 Mitogen-activated protein kinase kinase kinase 11 8.455e-09 0.38
F16P1_RAT Fbp1 Fructose-1,6-bisphosphatase 1 9.682e-09 0.31
FER_HUMAN FER Tyrosine-protein kinase Fer 1.17e-08 0.48
PTK6_HUMAN PTK6 Protein-tyrosine kinase 6 1.348e-08 0.53
GRM4_RAT Grm4 Metabotropic glutamate receptor 4 1.361e-08 0.30
MARK1_HUMAN MARK1 Serine/threonine-protein kinase MARK1 1.53e-08 0.48
PAK3_HUMAN PAK3 Serine/threonine-protein kinase PAK 3 1.633e-08 0.29
ST17A_HUMAN STK17A Serine/threonine-protein kinase 17A 3.391e-08 0.60
EPHB3_HUMAN EPHB3 Ephrin type-B receptor 3 3.575e-08 0.29
NEK9_HUMAN NEK9 Serine/threonine-protein kinase Nek9 3.684e-08 0.29
TLK2_HUMAN TLK2 Serine/threonine-protein kinase tousled-like 2 3.985e-08 0.29
SRMS_HUMAN SRMS Tyrosine-protein kinase Srms 4.967e-08 0.38
PAK6_HUMAN PAK6 Serine/threonine-protein kinase PAK 6 7.687e-08 0.38
NUAK1_HUMAN NUAK1 NUAK family SNF1-like kinase 1 8.455e-08 0.38
CDKL5_HUMAN CDKL5 Cyclin-dependent kinase-like 5 9.573e-08 0.29
HIPK3_HUMAN HIPK3 Homeodomain-interacting protein kinase 3 1.004e-07 0.29
CSKP_HUMAN CASK Peripheral plasma membrane protein CASK 1.031e-07 0.29
STK39_HUMAN STK39 STE20/SPS1-related proline-alanine-rich protein kinase 1.031e-07 0.29
GALR2_HUMAN GALR2 Galanin receptor type 2 1.065e-07 0.35
KCNJ6_HUMAN KCNJ6 G protein-activated inward rectifier potassium channel 2 1.511e-07 0.30
CLK1_HUMAN CLK1 Dual specificity protein kinase CLK1 1.695e-07 0.57
TEC_HUMAN TEC Tyrosine-protein kinase Tec 1.846e-07 0.29
M3K10_HUMAN MAP3K10 Mitogen-activated protein kinase kinase kinase 10 2.172e-07 0.38
CD11A_HUMAN CDK11A Cyclin-dependent kinase 11A 2.201e-07 0.29
CDK13_HUMAN CDK13 Cyclin-dependent kinase 13 2.201e-07 0.29
M3K20_HUMAN MAP3K20 Mitogen-activated protein kinase kinase kinase 20 2.413e-07 0.48
ACVR1_HUMAN ACVR1 Activin receptor type-1 2.516e-07 0.38
ENPP1_HUMAN ENPP1 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 2.666e-07 0.30
WNT3A_MOUSE Wnt3a Protein Wnt-3a 2.824e-07 0.28
CCRL2_HUMAN CCRL2 C-C chemokine receptor-like 2 4.001e-07 0.30
TLK1_HUMAN TLK1 Serine/threonine-protein kinase tousled-like 1 4.905e-07 0.29
HIPK1_HUMAN HIPK1 Homeodomain-interacting protein kinase 1 5.366e-07 0.29
MINK1_HUMAN MINK1 Misshapen-like kinase 1 5.399e-07 0.53
KPCD2_HUMAN PRKD2 Serine/threonine-protein kinase D2 5.891e-07 0.53
PLK1_HUMAN PLK1 Serine/threonine-protein kinase PLK1 6.556e-07 0.41
E2AK2_HUMAN EIF2AK2 Interferon-induced, double-stranded RNA-activated protein kinase 8.056e-07 0.48
M3K1_HUMAN MAP3K1 Mitogen-activated protein kinase kinase kinase 1 9.396e-07 0.29
NIM1_HUMAN NIM1K Serine/threonine-protein kinase NIM1 9.396e-07 0.29
ARAF_HUMAN ARAF Serine/threonine-protein kinase A-Raf 1.032e-06 0.33
CLTR1_CAVPO CYSLTR1 Cysteinyl leukotriene receptor 1 1.036e-06 0.32
P3C2G_HUMAN PIK3C2G Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma 1.036e-06 0.31
SL9A1_RAT Slc9a1 Sodium/hydrogen exchanger 1 1.105e-06 0.29
TYRO3_HUMAN TYRO3 Tyrosine-protein kinase receptor TYRO3 1.12e-06 0.48
SCN9A_HUMAN SCN9A Sodium channel protein type 9 subunit alpha 1.438e-06 0.35
CD11B_HUMAN CDK11B Cyclin-dependent kinase 11B 1.583e-06 0.29
KCNJ5_HUMAN KCNJ5 G protein-activated inward rectifier potassium channel 4 1.667e-06 0.30
CDK2_HUMAN CDK2 Cyclin-dependent kinase 2 1.672e-06 0.41
BRAF_MOUSE Braf Serine/threonine-protein kinase B-raf 1.783e-06 0.34
LDHA_HUMAN LDHA L-lactate dehydrogenase A chain 2.352e-06 0.30
GRM4_HUMAN GRM4 Metabotropic glutamate receptor 4 2.496e-06 0.30
NCOA1_HUMAN NCOA1 Nuclear receptor coactivator 1 2.656e-06 0.30
CDK18_HUMAN CDK18 Cyclin-dependent kinase 18 2.686e-06 0.29
PYGL_HUMAN PYGL Glycogen phosphorylase, liver form 3.355e-06 0.33
TF7L2_HUMAN TCF7L2 Transcription factor 7-like 2 3.447e-06 0.31
FGFR3_HUMAN FGFR3 Fibroblast growth factor receptor 3 3.611e-06 0.38
TAOK3_HUMAN TAOK3 Serine/threonine-protein kinase TAO3 3.81e-06 0.38
KCNJ3_HUMAN KCNJ3 G protein-activated inward rectifier potassium channel 1 4.697e-06 0.30
AGP1_YEAST AGP1 General amino acid permease AGP1 6.166e-06 0.29
MYLK3_HUMAN MYLK3 Myosin light chain kinase 3 6.733e-06 0.29
CDK7_HUMAN CDK7 Cyclin-dependent kinase 7 7.401e-06 0.53
DYRK2_HUMAN DYRK2 Dual specificity tyrosine-phosphorylation-regulated kinase 2 8.366e-06 0.60
TERT_HUMAN TERT Telomerase reverse transcriptase 9.887e-06 0.31

AZD8055

MTOR_HUMAN MTOR Serine/threonine-protein kinase mTOR 3.363e-201 1.00
LST8_HUMAN MLST8 Target of rapamycin complex subunit LST8 2.369e-70 1.00
RPTOR_HUMAN RPTOR Regulatory-associated protein of mTOR 2.369e-70 1.00
P85A_HUMAN PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha 3.641e-17 1.00
PK3CA_HUMAN PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 6.961e-13 1.00
MTOR_RAT Mtor Serine/threonine-protein kinase mTOR 1.222e-74 0.35
ATR_HUMAN ATR Serine/threonine-protein kinase ATR 3.042e-14 0.33
PK3CA_BOVIN PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5.121e-07 0.30
P3C2B_HUMAN PIK3C2B Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta 2.602e-06 0.30

Rocilinostat

HDAC3_HUMAN HDAC3 Histone deacetylase 3 4.525e-198 1.00
HDAC6_HUMAN HDAC6 Histone deacetylase 6 4.172e-187 1.00
HDAC1_HUMAN HDAC1 Histone deacetylase 1 3.976e-156 1.00
HDAC2_HUMAN HDAC2 Histone deacetylase 2 9.302e-106 1.00
HDAC8_HUMAN HDAC8 Histone deacetylase 8 1.356e-99 1.00
HDA10_HUMAN HDAC10 Polyamine deacetylase HDAC10 6.604e-97 1.00
NCOR2_HUMAN NCOR2 Nuclear receptor corepressor 2 1.657e-71 1.00
Q94F81_MAIZE hda106 HD2 type histone deacetylase HDA106 2.966e-111 0.66
Q9XYC7_PLAFA HDAC1 Histone deacetylase 8.724e-75 0.44
HDAC9_HUMAN HDAC9 Histone deacetylase 9 3.03e-69 0.54
ENPP2_MOUSE Enpp2 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 6.74e-66 0.49
Q7K6A1_PLAF7 Histone deacetylase 2.293e-63 0.44
SGMR2_HUMAN TMEM97 Sigma intracellular receptor 2 8.215e-60 0.36
HDA11_HUMAN HDAC11 Histone deacetylase 11 9.237e-60 0.54
HDAC7_HUMAN HDAC7 Histone deacetylase 7 1.428e-59 0.44
HDAC1_RAT Hdac1 Histone deacetylase 1 6.282e-58 0.56
HDAC5_HUMAN HDAC5 Histone deacetylase 5 1.791e-57 0.54
RCOR3_HUMAN RCOR3 REST corepressor 3 7.269e-55 0.44
Q9ZTP8_MAIZE hd1b Histone deacetylase 2.417e-52 0.44
HDAC1_MOUSE Hdac1 Histone deacetylase 1 4.521e-52 0.49
Q99P97_RAT Histone deacetylase 6 8.414e-45 0.36
ACER2_HUMAN ACER2 Alkaline ceramidase 2 1.579e-38 0.31
PA2A1_NAJMO Acidic phospholipase A2 CM-I 1.046e-36 0.29
CERT_HUMAN CERT1 Ceramide transfer protein 3.875e-36 0.29
TYTR_TRYCR TPR Trypanothione reductase 2.311e-35 0.35
ACES_TETCF ache Acetylcholinesterase 5.757e-35 0.36
HDAC4_HUMAN HDAC4 Histone deacetylase 4 3.307e-33 0.54
A5H660_SCHMA HDAC8 Histone deacetylase 8 5.218e-33 0.56
APAH_MYCRA aphA Acetylpolyamine amidohydrolase 1.574e-27 0.34
PRP19_YEAST PRP19 Pre-mRNA-processing factor 19 4.049e-26 0.30
AP2S1_RAT Ap2s1 AP-2 complex subunit sigma 2.199e-25 0.31
FOLH1_HUMAN FOLH1 Glutamate carboxypeptidase 2 2.357e-21 0.32
CAN2_BOVIN CAPN2 Calpain-2 catalytic subunit 1.048e-19 0.31
LIPL_HUMAN LPL Lipoprotein lipase 2.758e-19 0.31
CCND3_HUMAN CCND3 G1/S-specific cyclin-D3 9.178e-19 0.38
NAMPT_MOUSE Nampt Nicotinamide phosphoribosyltransferase 1.021e-18 0.30
COMT_PIG COMT Catechol O-methyltransferase 1.906e-18 0.31
CLPP_STAA8 clpP ATP-dependent Clp protease proteolytic subunit 2.139e-18 0.29
NAMPT_HUMAN NAMPT Nicotinamide phosphoribosyltransferase 5.169e-18 0.39
TRPV2_RAT Trpv2 Transient receptor potential cation channel subfamily V member 2 8.819e-18 0.30
HYES_RAT Ephx2 Bifunctional epoxide hydrolase 2 1.11e-16 0.39
ASAH1_HUMAN ASAH1 Acid ceramidase 1.11e-15 0.31
DRD1_PIG DRD1 D(1A) dopamine receptor 1.776e-15 0.39
DYR_MOUSE Dhfr Dihydrofolate reductase 2.22e-15 0.33
DXR_MYCS2 dxr 1-deoxy-D-xylulose 5-phosphate reductoisomerase 4.441e-15 0.29
5HT3A_CAVPO HTR3A 5-hydroxytryptamine receptor 3A 1.61e-14 0.35
KCNQ1_CAVPO KCNQ1 Potassium voltage-gated channel subfamily KQT member 1 3.919e-14 0.31
KCNA3_HUMAN KCNA3 Potassium voltage-gated channel subfamily A member 3 6.461e-14 0.36
GLUC_HUMAN GCG Glucagon 7.749e-14 0.30
PTAFR_HUMAN PTAFR Platelet-activating factor receptor 1.55e-13 0.38
KDM4E_HUMAN KDM4E Lysine-specific demethylase 4E 2.586e-13 0.32
DRD3_HUMAN DRD3 D(3) dopamine receptor 5.126e-13 0.39
S22A1_MOUSE Slc22a1 Solute carrier family 22 member 1 6.449e-13 0.28
P4HTM_HUMAN P4HTM Transmembrane prolyl 4-hydroxylase 2.236e-12 0.30
NR0B1_HUMAN NR0B1 Nuclear receptor subfamily 0 group B member 1 4.94e-12 0.44
SO2A1_RAT Slco2a1 Solute carrier organic anion transporter family member 2A1 1.032e-11 0.32
HYES_HUMAN EPHX2 Bifunctional epoxide hydrolase 2 1.512e-11 0.39
PTPRO_HUMAN PTPRO Receptor-type tyrosine-protein phosphatase O 1.659e-11 0.31
AMP1_PLAFQ M1 family aminopeptidase 2.868e-11 0.34
LUCI_AQULA Luciferin 4-monooxygenase 5.096e-11 0.29
HDAH_ALCSD hdaH Histone deacetylase-like amidohydrolase 6.193e-11 0.44
KDM3A_HUMAN KDM3A Lysine-specific demethylase 3A 1.408e-10 0.30
THAS_RAT Tbxas1 Thromboxane-A synthase 2.399e-10 0.35
LKHA4_MOUSE Lta4h Leukotriene A-4 hydrolase 2.648e-10 0.56
ACM2_PIG CHRM2 Muscarinic acetylcholine receptor M2 8.322e-10 0.34
AOFA_BOVIN MAOA Amine oxidase [flavin-containing] A 9.516e-10 0.34
ECR_BOMMO EcR Ecdysone receptor 1.111e-09 0.32
NCOR1_HUMAN NCOR1 Nuclear receptor corepressor 1 1.27e-09 0.44
DRD2_HUMAN DRD2 D(2) dopamine receptor 2.169e-09 0.39
TYSY_LACCA thyA Thymidylate synthase 2.412e-09 0.33
THAS_HUMAN TBXAS1 Thromboxane-A synthase 4.014e-09 0.37
DYN1_HUMAN DNM1 Dynamin-1 5.263e-09 0.32
MEP1B_HUMAN MEP1B Meprin A subunit beta 7.323e-09 0.30
LIPE_MOUSE Lipg Endothelial lipase 1.007e-08 0.31
HYEP_MOUSE Ephx1 Epoxide hydrolase 1 2.573e-08 0.33
DXR_ECOLI dxr 1-deoxy-D-xylulose 5-phosphate reductoisomerase 2.863e-08 0.30
EGLN2_HUMAN EGLN2 Egl nine homolog 2 3.436e-08 0.34
AMPN_PIG ANPEP Aminopeptidase N 3.929e-08 0.40
NU1M_BOVIN MT-ND1 NADH-ubiquinone oxidoreductase chain 1 7.592e-08 0.29
ACES_ELEEL ache Acetylcholinesterase 7.75e-08 0.36
CASP1_HUMAN CASP1 Caspase-1 9.719e-08 0.40
ACES_HUMAN ACHE Acetylcholinesterase 9.73e-08 0.36
HCAR3_HUMAN HCAR3 Hydroxycarboxylic acid receptor 3 1.223e-07 0.32
S22A8_HUMAN SLC22A8 Solute carrier family 22 member 8 1.755e-07 0.38
GBRA5_HUMAN GABRA5 Gamma-aminobutyric acid receptor subunit alpha-5 1.879e-07 0.35
CHLE_HUMAN BCHE Cholinesterase 3.516e-07 0.36
FAAH1_RAT Faah Fatty-acid amide hydrolase 1 7.208e-07 0.33
ADCY5_HUMAN ADCY5 Adenylate cyclase type 5 7.518e-07 0.29
DGLA_HUMAN DAGLA Sn1-specific diacylglycerol lipase alpha 8.53e-07 0.33
EST1_RABIT Liver carboxylesterase 1 1.225e-06 0.30
NEP_RABIT MME Neprilysin 1.556e-06 0.40
S22A1_RAT Slc22a1 Solute carrier family 22 member 1 2.124e-06 0.28
MMP17_HUMAN MMP17 Matrix metalloproteinase-17 2.488e-06 0.30
KDM4B_HUMAN KDM4B Lysine-specific demethylase 4B 2.749e-06 0.32
AOFB_BOVIN MAOB Amine oxidase [flavin-containing] B 3.573e-06 0.31
DRD4_HUMAN DRD4 D(4) dopamine receptor 3.927e-06 0.39
GRIA4_RAT Gria4 Glutamate receptor 4 4.466e-06 0.33
S22A6_HUMAN SLC22A6 Solute carrier family 22 member 6 4.592e-06 0.38
HYEP_HUMAN EPHX1 Epoxide hydrolase 1 5.716e-06 0.33
SGMR1_HUMAN SIGMAR1 Sigma non-opioid intracellular receptor 1 7.157e-06 0.36
DGAT1_MOUSE Dgat1 Diacylglycerol O-acyltransferase 1 7.338e-06 0.30
KDM2A_HUMAN KDM2A Lysine-specific demethylase 2A 7.69e-06 0.29
MTR1A_HUMAN MTNR1A Melatonin receptor type 1A 9.773e-06 0.32

Oleandrin

NOTC1_MOUSE Notch1 Neurogenic locus notch homolog protein 1 7.934e-181 1.00
AT1A1_CANLF ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 7.881e-98 0.63
AT1A1_HUMAN ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 8.046e-88 0.56
AT1A3_RAT Atp1a3 Sodium/potassium-transporting ATPase subunit alpha-3 5.548e-81 0.56
AT1A2_RAT Atp1a2 Sodium/potassium-transporting ATPase subunit alpha-2 2.736e-73 0.56
SO4C1_HUMAN SLCO4C1 Solute carrier organic anion transporter family member 4C1 4.998e-62 0.63
AT1A1_PIG ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 1.393e-47 0.31
AT1B3_RAT Atp1b3 Sodium/potassium-transporting ATPase subunit beta-3 2.789e-46 0.37
AT12A_HUMAN ATP12A Potassium-transporting ATPase alpha chain 2 3.5e-41 0.46
AT1A4_RAT Atp1a4 Sodium/potassium-transporting ATPase subunit alpha-4 7.083e-39 0.57
AT1B1_RAT Atp1b1 Sodium/potassium-transporting ATPase subunit beta-1 7.083e-39 0.57
IF4A1_MOUSE Eif4a1 Eukaryotic initiation factor 4A-I 4.858e-32 0.32
AT1A1_RAT Atp1a1 Sodium/potassium-transporting ATPase subunit alpha-1 1.016e-29 0.37
SO1A4_RAT Slco1a4 Solute carrier organic anion transporter family member 1A4 9.245e-25 0.56
NOTC1_HUMAN NOTCH1 Neurogenic locus notch homolog protein 1 1.221e-15 0.39
ABCBB_RAT Abcb11 Bile salt export pump 7.616e-12 0.29
PAX8_HUMAN PAX8 Paired box protein Pax-8 2.885e-06 0.62

Mocetinostat

HDAC1_HUMAN HDAC1 Histone deacetylase 1 2.254e-178 1.00
NCOR1_HUMAN NCOR1 Nuclear receptor corepressor 1 2.378e-161 1.00
HDAC2_HUMAN HDAC2 Histone deacetylase 2 7.647e-107 1.00
HDAC3_HUMAN HDAC3 Histone deacetylase 3 3.168e-100 1.00
NCOR2_HUMAN NCOR2 Nuclear receptor corepressor 2 2.924e-57 1.00
HDA11_HUMAN HDAC11 Histone deacetylase 11 2.9e-11 1.00
WDR48_HUMAN WDR48 WD repeat-containing protein 48 1.545e-81 0.41
UBP1_HUMAN USP1 Ubiquitin carboxyl-terminal hydrolase 1 4.674e-80 0.41
TF7L2_HUMAN TCF7L2 Transcription factor 7-like 2 3.435e-77 0.38
CTNB1_HUMAN CTNNB1 Catenin beta-1 3.483e-71 0.38
BCR_HUMAN BCR Breakpoint cluster region protein 2.569e-68 0.39
CXCR4_RAT Cxcr4 C-X-C chemokine receptor type 4 1.125e-63 0.39
GSK3B_MOUSE Gsk3b Glycogen synthase kinase-3 beta 2.709e-51 0.31
FABH_STAAM fabH 3-oxoacyl-[acyl-carrier-protein] synthase 3 1.312e-47 0.30
HDAC1_MOUSE Hdac1 Histone deacetylase 1 5.337e-46 0.45
TNKS1_MOUSE Tnks Poly [ADP-ribose] polymerase tankyrase-1 1.007e-38 0.31
TNKS2_MOUSE Tnks2 Poly [ADP-ribose] polymerase tankyrase-2 1.007e-38 0.31
PGFRA_MOUSE Pdgfra Platelet-derived growth factor receptor alpha 4.019e-38 0.47
FABH_HAEIN fabH 3-oxoacyl-[acyl-carrier-protein] synthase 3 7.142e-37 0.29
GPR39_MOUSE Gpr39 G-protein coupled receptor 39 2.292e-33 0.38
NAMPT_MOUSE Nampt Nicotinamide phosphoribosyltransferase 1.485e-31 0.34
PGFRA_HUMAN PDGFRA Platelet-derived growth factor receptor alpha 3.05e-31 0.55
ABL1_HUMAN ABL1 Tyrosine-protein kinase ABL1 7.017e-31 0.75
FABH_STRP3 fabH 3-oxoacyl-[acyl-carrier-protein] synthase 3 1.508e-30 0.30
SMG1_HUMAN SMG1 Serine/threonine-protein kinase SMG1 5.554e-30 0.30
PRIO_SHEEP PRNP Major prion protein 1.545e-29 0.34
NEMO_HUMAN IKBKG NF-kappa-B essential modulator 6.055e-29 0.38
GYRB_STRPN gyrB DNA gyrase subunit B 1.694e-28 0.30
Q7X1P7_STREE parE DNA topoisomerase (ATP-hydrolyzing) 1.694e-28 0.30
SO2A1_RAT Slco2a1 Solute carrier organic anion transporter family member 2A1 1.715e-28 0.31
HDAC8_HUMAN HDAC8 Histone deacetylase 8 8.856e-26 0.70
ABL1_MOUSE Abl1 Tyrosine-protein kinase ABL1 9.405e-26 0.47
TIE2_HUMAN TEK Angiopoietin-1 receptor 5.02e-25 0.38
PORCN_MOUSE Porcn Protein-serine O-palmitoleoyltransferase porcupine 1.432e-24 0.36
TMIG3_HUMAN TMIGD3 Transmembrane domain-containing protein TMIGD3 9.709e-24 0.42
FA12_HUMAN F12 Coagulation factor XII 1.233e-23 0.36
SCN9A_RAT Scn9a Sodium channel protein type 9 subunit alpha 1.323e-23 0.42
DYR_ENTFC folA Dihydrofolate reductase 1.915e-23 0.29
HDAC6_HUMAN HDAC6 Histone deacetylase 6 4.351e-23 0.70
PGFRB_HUMAN PDGFRB Platelet-derived growth factor receptor beta 5.422e-23 0.75
KLK14_HUMAN KLK14 Kallikrein-14 1.676e-21 0.34
NAMPT_HUMAN NAMPT Nicotinamide phosphoribosyltransferase 9.981e-21 0.58
ROCK2_HUMAN ROCK2 Rho-associated protein kinase 2 5.165e-20 0.34
KIT_HUMAN KIT Mast/stem cell growth factor receptor Kit 1.585e-19 0.55
DNM3L_HUMAN DNMT3L DNA (cytosine-5)-methyltransferase 3-like 2.322e-19 0.31
SIR3_HUMAN SIRT3 NAD-dependent protein deacetylase sirtuin-3, mitochondrial 7.007e-19 0.37
ATR_HUMAN ATR Serine/threonine-protein kinase ATR 1.205e-18 0.41
CCNE1_HUMAN CCNE1 G1/S-specific cyclin-E1 1.827e-18 0.35
GYRB_STAAU gyrB DNA gyrase subunit B 2.016e-18 0.32
FABH_ENTFA fabH 3-oxoacyl-[acyl-carrier-protein] synthase 3 2.186e-18 0.41
GPR39_HUMAN GPR39 G-protein coupled receptor 39 2.867e-18 0.38
LUCI_AQULA Luciferin 4-monooxygenase 5.68e-18 0.35
TPH1_HUMAN TPH1 Tryptophan 5-hydroxylase 1 7.093e-18 0.34
TBK1_HUMAN TBK1 Serine/threonine-protein kinase TBK1 1.478e-17 0.32
SIR2_HUMAN SIRT2 NAD-dependent protein deacetylase sirtuin-2 3.96e-17 0.37
KDM4D_HUMAN KDM4D Lysine-specific demethylase 4D 1.11e-16 0.35
VHL_HUMAN VHL von Hippel-Lindau disease tumor suppressor 1.11e-16 0.36
CLK1_HUMAN CLK1 Dual specificity protein kinase CLK1 2.22e-16 0.47
EPHA8_HUMAN EPHA8 Ephrin type-A receptor 8 2.22e-16 0.47
INHBA_MOUSE Inhba Inhibin beta A chain 2.22e-16 0.31
LYOX_HUMAN LOX Protein-lysine 6-oxidase 2.22e-16 0.31
PGFRB_MOUSE Pdgfrb Platelet-derived growth factor receptor beta 3.331e-16 0.47
TERA_HUMAN VCP Transitional endoplasmic reticulum ATPase 5.551e-16 0.40
FOLC_HUMAN FPGS Folylpolyglutamate synthase, mitochondrial 6.661e-16 0.29
CLK4_HUMAN CLK4 Dual specificity protein kinase CLK4 9.992e-16 0.47
CDK2_HUMAN CDK2 Cyclin-dependent kinase 2 1.11e-15 0.40
KCC2D_HUMAN CAMK2D Calcium/calmodulin-dependent protein kinase type II subunit delta 1.554e-15 0.44
SHH_MOUSE Shh Sonic hedgehog protein 1.554e-15 0.37
ISPH_AQUAE ispH 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 2.109e-15 0.29
STAT3_MOUSE Stat3 Signal transducer and activator of transcription 3 4.219e-15 0.35
AKT3_HUMAN AKT3 RAC-gamma serine/threonine-protein kinase 5.995e-15 0.44
CLK3_HUMAN CLK3 Dual specificity protein kinase CLK3 8.216e-15 0.40
S47A2_HUMAN SLC47A2 Multidrug and toxin extrusion protein 2 1.044e-14 0.47
TNKS1_HUMAN TNKS Poly [ADP-ribose] polymerase tankyrase-1 1.11e-14 0.33
TRPV1_HUMAN TRPV1 Transient receptor potential cation channel subfamily V member 1 1.354e-14 0.40
CP2A6_HUMAN CYP2A6 Cytochrome P450 2A6 1.366e-14 0.32
VGFR1_HUMAN FLT1 Vascular endothelial growth factor receptor 1 1.432e-14 0.35
KLK5_HUMAN KLK5 Kallikrein-5 1.987e-14 0.36
AURKA_HUMAN AURKA Aurora kinase A 4.685e-14 0.40
CP1A2_HUMAN CYP1A2 Cytochrome P450 1A2 5.163e-14 0.43
A6QR73_RAT Gpr39 G protein-coupled receptor 39 1.463e-13 0.33
FA10_HUMAN F10 Coagulation factor X 1.557e-13 0.38
JAK2_MOUSE Jak2 Tyrosine-protein kinase JAK2 2.122e-13 0.33
IKKB_HUMAN IKBKB Inhibitor of nuclear factor kappa-B kinase subunit beta 3.482e-13 0.41
DDR2_HUMAN DDR2 Discoidin domain-containing receptor 2 7.47e-13 0.47
SUCR1_HUMAN SUCNR1 Succinate receptor 1 8.556e-13 0.31
DYR1A_HUMAN DYRK1A Dual specificity tyrosine-phosphorylation-regulated kinase 1A 8.988e-13 0.42
P4HTM_HUMAN P4HTM Transmembrane prolyl 4-hydroxylase 1.118e-12 0.33
VGFR2_HUMAN KDR Vascular endothelial growth factor receptor 2 1.497e-12 0.75
DYR1B_HUMAN DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B 2.139e-12 0.42
LOXL2_HUMAN LOXL2 Lysyl oxidase homolog 2 2.925e-12 0.36
DKK1_HUMAN DKK1 Dickkopf-related protein 1 3.999e-12 0.30
ACOD_HUMAN SCD Acyl-CoA desaturase 5.621e-12 0.39
CLK2_HUMAN CLK2 Dual specificity protein kinase CLK2 6.302e-12 0.40
SCNAA_MOUSE Scn10a Sodium channel protein type 10 subunit alpha 6.66e-12 0.33
CP3A4_HUMAN CYP3A4 Cytochrome P450 3A4 6.998e-12 0.43
ABL2_HUMAN ABL2 Tyrosine-protein kinase ABL2 7.008e-12 0.47
STAT6_HUMAN STAT6 Signal transducer and activator of transcription 6 7.864e-12 0.33
TRPV1_RAT Trpv1 Transient receptor potential cation channel subfamily V member 1 8.577e-12 0.40
IKKE_HUMAN IKBKE Inhibitor of nuclear factor kappa-B kinase subunit epsilon 1.157e-11 0.32
SIR1_HUMAN SIRT1 NAD-dependent protein deacetylase sirtuin-1 1.27e-11 0.37
PTAFR_HUMAN PTAFR Platelet-activating factor receptor 1.655e-11 0.36
KLKB1_HUMAN KLKB1 Plasma kallikrein 1.704e-11 0.35
O96526_LEIMA CRK3 Cdc2-related kinase 2.335e-11 0.33
C11B1_HUMAN CYP11B1 Cytochrome P450 11B1, mitochondrial 2.445e-11 0.38
LSHR_HUMAN LHCGR Lutropin-choriogonadotropic hormone receptor 2.664e-11 0.28
C11B2_HUMAN CYP11B2 Cytochrome P450 11B2, mitochondrial 3.442e-11 0.38
ABCC9_HUMAN ABCC9 ATP-binding cassette sub-family C member 9 4.726e-11 0.32
KPCA_HUMAN PRKCA Protein kinase C alpha type 5.807e-11 0.52
KLK1_HUMAN KLK1 Kallikrein-1 6.659e-11 0.33
RIR1_HUMAN RRM1 Ribonucleoside-diphosphate reductase large subunit 6.878e-11 0.29
FNTB_BOVIN FNTB Protein farnesyltransferase subunit beta 1.647e-10 0.33
GSK3B_HUMAN GSK3B Glycogen synthase kinase-3 beta 1.658e-10 0.37
PA_I34A1 PA Polymerase acidic protein 1.722e-10 0.31
PIM3_HUMAN PIM3 Serine/threonine-protein kinase pim-3 2.024e-10 0.36
C11B1_RAT Cyp11b1 Cytochrome P450 11B1, mitochondrial 2.027e-10 0.30
LYN_HUMAN LYN Tyrosine-protein kinase Lyn 2.344e-10 0.47
IF4H_HUMAN EIF4H Eukaryotic translation initiation factor 4H 3.149e-10 0.34
PGFRB_RAT Pdgfrb Platelet-derived growth factor receptor beta 3.296e-10 0.47
TNIK_HUMAN TNIK TRAF2 and NCK-interacting protein kinase 4.641e-10 0.32
CDK7_HUMAN CDK7 Cyclin-dependent kinase 7 6.497e-10 0.31
PRTN3_HUMAN PRTN3 Myeloblastin 7.382e-10 0.29
LCK_MOUSE Lck Proto-oncogene tyrosine-protein kinase LCK 8.534e-10 0.29
FGR_HUMAN FGR Tyrosine-protein kinase Fgr 1.106e-09 0.47
IKKA_HUMAN CHUK Inhibitor of nuclear factor kappa-B kinase subunit alpha 1.213e-09 0.38
MRCKB_HUMAN CDC42BPB Serine/threonine-protein kinase MRCK beta 1.293e-09 0.38
M3K20_HUMAN MAP3K20 Mitogen-activated protein kinase kinase kinase 20 1.346e-09 0.47
KLK7_HUMAN KLK7 Kallikrein-7 1.455e-09 0.36
KCJ11_HUMAN KCNJ11 ATP-sensitive inward rectifier potassium channel 11 1.643e-09 0.32
AA2BR_MOUSE Adora2b Adenosine receptor A2b 2.15e-09 0.29
Q9FBC5_STREE fabK Enoyl-ACP reductase II 2.808e-09 0.29
Q76129_9HIV1 gag Structural capsid protein 2.967e-09 0.33
MK08_HUMAN MAPK8 Mitogen-activated protein kinase 8 3.673e-09 0.47
SMS2_HUMAN SGMS2 Phosphatidylcholine:ceramide cholinephosphotransferase 2 4.08e-09 0.30
AURKB_HUMAN AURKB Aurora kinase B 4.299e-09 0.35
MK09_HUMAN MAPK9 Mitogen-activated protein kinase 9 4.447e-09 0.47
DDR1_HUMAN DDR1 Epithelial discoidin domain-containing receptor 1 7.336e-09 0.47
FNTA_BOVIN FNTA Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha 7.989e-09 0.33
EPHB4_HUMAN EPHB4 Ephrin type-B receptor 4 8.112e-09 0.38
MK10_RAT Mapk10 Mitogen-activated protein kinase 10 1.146e-08 0.32
NR1H4_HUMAN NR1H4 Bile acid receptor 1.322e-08 0.33
THRB_HUMAN F2 Prothrombin 1.356e-08 0.41
AA2AR_HUMAN ADORA2A Adenosine receptor A2a 1.673e-08 0.34
CDC7_HUMAN CDC7 Cell division cycle 7-related protein kinase 1.963e-08 0.39
MK10_HUMAN MAPK10 Mitogen-activated protein kinase 10 1.992e-08 0.47
HDAC5_HUMAN HDAC5 Histone deacetylase 5 2.11e-08 0.40
IRAK1_HUMAN IRAK1 Interleukin-1 receptor-associated kinase 1 3.094e-08 0.47
AA1R_RAT Adora1 Adenosine receptor A1 3.402e-08 0.34
AA3R_HUMAN ADORA3 Adenosine receptor A3 3.439e-08 0.40
STXA_SHIDY stxA Shiga toxin subunit A 3.985e-08 0.29
M4K4_HUMAN MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4 4.18e-08 0.34
A5H660_SCHMA HDAC8 Histone deacetylase 8 4.697e-08 0.30
S22A2_HUMAN SLC22A2 Solute carrier family 22 member 2 4.848e-08 0.47
GRM5_RAT Grm5 Metabotropic glutamate receptor 5 5.411e-08 0.39
WNT3A_MOUSE Wnt3a Protein Wnt-3a 7.758e-08 0.31
CCNB2_HUMAN CCNB2 G2/mitotic-specific cyclin-B2 9.365e-08 0.30
CCNB3_HUMAN CCNB3 G2/mitotic-specific cyclin-B3 9.365e-08 0.30
S47A1_HUMAN SLC47A1 Multidrug and toxin extrusion protein 1 1.166e-07 0.47
PIM2_HUMAN PIM2 Serine/threonine-protein kinase pim-2 1.224e-07 0.37
AA1R_HUMAN ADORA1 Adenosine receptor A1 1.312e-07 0.39
CDK5_HUMAN CDK5 Cyclin-dependent-like kinase 5 1.465e-07 0.36
EPHA3_HUMAN EPHA3 Ephrin type-A receptor 3 1.511e-07 0.38
CAH3_HUMAN CA3 Carbonic anhydrase 3 1.631e-07 0.47
PI42C_HUMAN PIP4K2C Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma 1.631e-07 0.47
BRAF_HUMAN BRAF Serine/threonine-protein kinase B-raf 1.741e-07 0.47
NR2E3_HUMAN NR2E3 Photoreceptor-specific nuclear receptor 1.872e-07 0.46
IRAK4_HUMAN IRAK4 Interleukin-1 receptor-associated kinase 4 1.913e-07 0.44
KDM4E_HUMAN KDM4E Lysine-specific demethylase 4E 1.955e-07 0.34
MDR1_HUMAN ABCB1 ATP-dependent translocase ABCB1 2.033e-07 0.47
E2AK2_HUMAN EIF2AK2 Interferon-induced, double-stranded RNA-activated protein kinase 2.468e-07 0.30
STK11_HUMAN STK11 Serine/threonine-protein kinase STK11 2.542e-07 0.30
CP26A_HUMAN CYP26A1 Cytochrome P450 26A1 3.125e-07 0.31
M4K5_HUMAN MAP4K5 Mitogen-activated protein kinase kinase kinase kinase 5 3.314e-07 0.34
DYR1A_RAT Dyrk1a Dual specificity tyrosine-phosphorylation-regulated kinase 1A 3.453e-07 0.39
FLT3_HUMAN FLT3 Receptor-type tyrosine-protein kinase FLT3 3.561e-07 0.47
GYRA_STAAU gyrA DNA gyrase subunit A 3.621e-07 0.30
A1Z199_HUMAN BCR/ABL fusion BCR/ABL p210 fusion protein 5.037e-07 0.47
GALR3_HUMAN GALR3 Galanin receptor type 3 5.357e-07 0.35
CAH13_MOUSE Ca13 Carbonic anhydrase 13 5.412e-07 0.47
PIM1_HUMAN PIM1 Serine/threonine-protein kinase pim-1 5.44e-07 0.37
KLF5_HUMAN KLF5 Krueppel-like factor 5 5.772e-07 0.29
CP2D6_HUMAN CYP2D6 Cytochrome P450 2D6 6.813e-07 0.43
CAH15_MOUSE Ca15 Carbonic anhydrase 15 7.068e-07 0.47
CDPK1_PLAF7 CPK1 Calcium-dependent protein kinase 1 8.228e-07 0.38
FRK_HUMAN FRK Tyrosine-protein kinase FRK 8.464e-07 0.47
AOC1_RAT Aoc1 Amiloride-sensitive amine oxidase [copper-containing] 9.396e-07 0.29
STA5A_HUMAN STAT5A Signal transducer and activator of transcription 5A 9.396e-07 0.29
BLK_HUMAN BLK Tyrosine-protein kinase Blk 9.985e-07 0.47
BKRB1_HUMAN BDKRB1 B1 bradykinin receptor 1.023e-06 0.32
SMO_HUMAN SMO Smoothened homolog 1.034e-06 0.34
DNM3A_HUMAN DNMT3A DNA (cytosine-5)-methyltransferase 3A 1.069e-06 0.31
ROCK1_HUMAN ROCK1 Rho-associated protein kinase 1 1.147e-06 0.34
PAI1_HUMAN SERPINE1 Plasminogen activator inhibitor 1 1.172e-06 0.31
HDAC9_HUMAN HDAC9 Histone deacetylase 9 1.218e-06 0.40
HPGDS_HUMAN HPGDS Hematopoietic prostaglandin D synthase 1.358e-06 0.31
AA2BR_HUMAN ADORA2B Adenosine receptor A2b 1.394e-06 0.33
CDK1_HUMAN CDK1 Cyclin-dependent kinase 1 1.409e-06 0.31
HDAC4_HUMAN HDAC4 Histone deacetylase 4 1.572e-06 0.40
AKT2_HUMAN AKT2 RAC-beta serine/threonine-protein kinase 1.698e-06 0.44
PMYT1_HUMAN PKMYT1 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase 1.841e-06 0.33
CD5R1_HUMAN CDK5R1 Cyclin-dependent kinase 5 activator 1 1.844e-06 0.36
IGF1R_HUMAN IGF1R Insulin-like growth factor 1 receptor 2.111e-06 0.32
HDAC7_HUMAN HDAC7 Histone deacetylase 7 2.144e-06 0.40
LDLR_HUMAN LDLR Low-density lipoprotein receptor 2.237e-06 0.29
MK14_HUMAN MAPK14 Mitogen-activated protein kinase 14 2.411e-06 0.38
BMR1A_HUMAN BMPR1A Bone morphogenetic protein receptor type-1A 2.848e-06 0.33
PK3C3_HUMAN PIK3C3 Phosphatidylinositol 3-kinase catalytic subunit type 3 3.077e-06 0.34
CP2CJ_HUMAN CYP2C19 Cytochrome P450 2C19 3.482e-06 0.43
INSR_HUMAN INSR Insulin receptor 3.579e-06 0.32
WNT3_HUMAN WNT3 Proto-oncogene Wnt-3 3.643e-06 0.31
GLCM_HUMAN GBA Lysosomal acid glucosylceramidase 4.068e-06 0.38
ARBK1_HUMAN GRK2 Beta-adrenergic receptor kinase 1 4.136e-06 0.30
RIOK2_HUMAN RIOK2 Serine/threonine-protein kinase RIO2 4.224e-06 0.35
DNM3B_HUMAN DNMT3B DNA (cytosine-5)-methyltransferase 3B 4.399e-06 0.31
LCK_HUMAN LCK Tyrosine-protein kinase Lck 4.399e-06 0.47
STK33_HUMAN STK33 Serine/threonine-protein kinase 33 4.548e-06 0.33
HS90A_HUMAN HSP90AA1 Heat shock protein HSP 90-alpha 4.667e-06 0.33
PORCN_HUMAN PORCN Protein-serine O-palmitoleoyltransferase porcupine 4.706e-06 0.34
S28A2_HUMAN SLC28A2 Sodium/nucleoside cotransporter 2 5.201e-06 0.33
FES_HUMAN FES Tyrosine-protein kinase Fes/Fps 5.242e-06 0.29
JAK3_HUMAN JAK3 Tyrosine-protein kinase JAK3 5.36e-06 0.38
PLEC_HUMAN PLEC Plectin 5.476e-06 0.30
HPSE_HUMAN HPSE Heparanase 5.617e-06 0.31
STABP_HUMAN STAMBP STAM-binding protein 5.668e-06 0.30
JAK2_HUMAN JAK2 Tyrosine-protein kinase JAK2 5.796e-06 0.41
CCNA2_HUMAN CCNA2 Cyclin-A2 6.077e-06 0.35
EPHA5_HUMAN EPHA5 Ephrin type-A receptor 5 6.234e-06 0.38
ERBB2_HUMAN ERBB2 Receptor tyrosine-protein kinase erbB-2 6.343e-06 0.35
ABCG2_HUMAN ABCG2 Broad substrate specificity ATP-binding cassette transporter ABCG2 6.713e-06 0.47
MAPK2_HUMAN MAPKAPK2 MAP kinase-activated protein kinase 2 6.746e-06 0.31
HYES_HUMAN EPHX2 Bifunctional epoxide hydrolase 2 6.76e-06 0.37
SGK2_HUMAN SGK2 Serine/threonine-protein kinase Sgk2 7.566e-06 0.34
MP2K6_HUMAN MAP2K6 Dual specificity mitogen-activated protein kinase kinase 6 8.03e-06 0.29
CSF1R_HUMAN CSF1R Macrophage colony-stimulating factor 1 receptor 8.552e-06 0.47

Digitoxin

AT1A1_CANLF ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 5.845e-167 1.00
SO4C1_HUMAN SLCO4C1 Solute carrier organic anion transporter family member 4C1 6.798e-92 1.00
STAT3_HUMAN STAT3 Signal transducer and activator of transcription 3 8.934e-06 1.00
NOTC1_MOUSE Notch1 Neurogenic locus notch homolog protein 1 4.533e-139 0.83
AT1A1_HUMAN ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 1.031e-121 0.81
AT1A3_RAT Atp1a3 Sodium/potassium-transporting ATPase subunit alpha-3 2.12e-110 0.81
AT1A2_RAT Atp1a2 Sodium/potassium-transporting ATPase subunit alpha-2 6.901e-100 0.81
AT12A_HUMAN ATP12A Potassium-transporting ATPase alpha chain 2 7.155e-65 0.65
AT1A1_PIG ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 5.668e-59 0.40
AT1B3_RAT Atp1b3 Sodium/potassium-transporting ATPase subunit beta-3 1.491e-58 0.47
AT1A4_RAT Atp1a4 Sodium/potassium-transporting ATPase subunit alpha-4 4.664e-49 0.81
AT1B1_RAT Atp1b1 Sodium/potassium-transporting ATPase subunit beta-1 4.664e-49 0.81
AT1A1_RAT Atp1a1 Sodium/potassium-transporting ATPase subunit alpha-1 1.606e-37 0.47
SO1A4_RAT Slco1a4 Solute carrier organic anion transporter family member 1A4 1.561e-35 0.81
NOTC1_HUMAN NOTCH1 Neurogenic locus notch homolog protein 1 6.536e-19 0.46
NMDE3_HUMAN GRIN2C Glutamate receptor ionotropic, NMDA 2C 1.126e-18 0.30
NMDE4_HUMAN GRIN2D Glutamate receptor ionotropic, NMDA 2D 1.332e-15 0.30
PAX8_HUMAN PAX8 Paired box protein Pax-8 2.985e-08 0.81
KLF5_HUMAN KLF5 Krueppel-like factor 5 3.252e-07 0.47
SO1A1_RAT Slco1a1 Solute carrier organic anion transporter family member 1A1 5.815e-07 0.28
SHBG_HUMAN SHBG Sex hormone-binding globulin 8.485e-07 0.31
RORG_MOUSE Rorc Nuclear receptor ROR-gamma 3.822e-06 0.81

Pelitinib

EGFR_HUMAN EGFR Epidermal growth factor receptor 2.875e-150 1.00
ERBB2_HUMAN ERBB2 Receptor tyrosine-protein kinase erbB-2 4.041e-106 1.00
SRC_HUMAN SRC Proto-oncogene tyrosine-protein kinase Src 3.007e-75 1.00
WEE2_HUMAN WEE2 Wee1-like protein kinase 2 1.65e-52 1.00
ULK3_MOUSE Ulk3 Serine/threonine-protein kinase ULK3 3.682e-51 1.00
ST32B_HUMAN STK32B Serine/threonine-protein kinase 32B 1.025e-48 1.00
STK3_MOUSE Stk3 Serine/threonine-protein kinase 3 6.524e-44 1.00
STK24_HUMAN STK24 Serine/threonine-protein kinase 24 2.36e-41 1.00
MP2K1_HUMAN MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 1.085e-40 1.00
M3K4_HUMAN MAP3K4 Mitogen-activated protein kinase kinase kinase 4 1.698e-38 1.00
STK36_HUMAN STK36 Serine/threonine-protein kinase 36 5.122e-38 1.00
TBA1A_RAT Tuba1a Tubulin alpha-1A chain 7.766e-37 1.00
STK25_HUMAN STK25 Serine/threonine-protein kinase 25 4.792e-34 1.00
KC1AL_HUMAN CSNK1A1L Casein kinase I isoform alpha-like 7.496e-32 1.00
PHKG1_HUMAN PHKG1 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 1.853e-31 1.00
NUAK2_HUMAN NUAK2 NUAK family SNF1-like kinase 2 5.64e-31 1.00
PMYT1_HUMAN PKMYT1 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase 1.491e-30 1.00
STK4_HUMAN STK4 Serine/threonine-protein kinase 4 5.257e-30 1.00
STK10_HUMAN STK10 Serine/threonine-protein kinase 10 7.239e-29 1.00
ST38L_HUMAN STK38L Serine/threonine-protein kinase 38-like 3.59e-28 1.00
CTRO_HUMAN CIT Citron Rho-interacting kinase 8.995e-28 1.00
M4K3_HUMAN MAP4K3 Mitogen-activated protein kinase kinase kinase kinase 3 5.271e-27 1.00
EPHA6_HUMAN EPHA6 Ephrin type-A receptor 6 2.63e-26 1.00
EPHA8_HUMAN EPHA8 Ephrin type-A receptor 8 3.417e-26 1.00
M4K1_HUMAN MAP4K1 Mitogen-activated protein kinase kinase kinase kinase 1 5.265e-26 1.00
TXK_HUMAN TXK Tyrosine-protein kinase TXK 5.959e-26 1.00
VGFR2_HUMAN KDR Vascular endothelial growth factor receptor 2 6.173e-26 1.00
DMPK_HUMAN DMPK Myotonin-protein kinase 9.616e-26 1.00
CDK16_HUMAN CDK16 Cyclin-dependent kinase 16 1.537e-25 1.00
SIK2_HUMAN SIK2 Serine/threonine-protein kinase SIK2 2.211e-25 1.00
DCLK3_HUMAN DCLK3 Serine/threonine-protein kinase DCLK3 1.654e-24 1.00
TIE1_HUMAN TIE1 Tyrosine-protein kinase receptor Tie-1 7.131e-24 1.00
EPHA5_HUMAN EPHA5 Ephrin type-A receptor 5 2.052e-23 1.00
COQ8B_HUMAN COQ8B Atypical kinase COQ8B, mitochondrial 9.712e-23 1.00
E2AK4_HUMAN EIF2AK4 eIF-2-alpha kinase GCN2 1.95e-20 1.00
EPHB1_HUMAN EPHB1 Ephrin type-B receptor 1 2.134e-20 1.00
CSF1R_HUMAN CSF1R Macrophage colony-stimulating factor 1 receptor 2.242e-20 1.00
LYN_HUMAN LYN Tyrosine-protein kinase Lyn 3.028e-20 1.00
GAK_HUMAN GAK Cyclin-G-associated kinase 3.228e-20 1.00
MYLK2_HUMAN MYLK2 Myosin light chain kinase 2, skeletal/cardiac muscle 5.199e-20 1.00
STK33_HUMAN STK33 Serine/threonine-protein kinase 33 4.927e-19 1.00
FGR_HUMAN FGR Tyrosine-protein kinase Fgr 8.845e-19 1.00
BMP2K_HUMAN BMP2K BMP-2-inducible protein kinase 2.657e-18 1.00
PI42B_HUMAN PIP4K2B Phosphatidylinositol 5-phosphate 4-kinase type-2 beta 3.874e-18 1.00
MARK1_HUMAN MARK1 Serine/threonine-protein kinase MARK1 4.449e-17 1.00
EPHA3_HUMAN EPHA3 Ephrin type-A receptor 3 2.22e-16 1.00
ABL2_HUMAN ABL2 Tyrosine-protein kinase ABL2 3.331e-16 1.00
CSK_HUMAN CSK Tyrosine-protein kinase CSK 3.331e-16 1.00
KKCC1_HUMAN CAMKK1 Calcium/calmodulin-dependent protein kinase kinase 1 3.331e-16 1.00
AAK1_HUMAN AAK1 AP2-associated protein kinase 1 7.105e-15 1.00
ST17B_HUMAN STK17B Serine/threonine-protein kinase 17B 1.199e-14 1.00
KCC1D_HUMAN CAMK1D Calcium/calmodulin-dependent protein kinase type 1D 1.232e-14 1.00
FES_HUMAN FES Tyrosine-protein kinase Fes/Fps 7.905e-14 1.00
KKCC2_HUMAN CAMKK2 Calcium/calmodulin-dependent protein kinase kinase 2 7.024e-13 1.00
FYN_HUMAN FYN Tyrosine-protein kinase Fyn 1.334e-12 1.00
PHKG2_HUMAN PHKG2 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 1.025e-11 1.00
CLK3_HUMAN CLK3 Dual specificity protein kinase CLK3 1.434e-11 1.00
E2AK2_HUMAN EIF2AK2 Interferon-induced, double-stranded RNA-activated protein kinase 1.924e-11 1.00
TNIK_HUMAN TNIK TRAF2 and NCK-interacting protein kinase 1.93e-11 1.00
BMX_HUMAN BMX Cytoplasmic tyrosine-protein kinase BMX 4.315e-11 1.00
YES_HUMAN YES1 Tyrosine-protein kinase Yes 8.072e-11 1.00
FER_HUMAN FER Tyrosine-protein kinase Fer 2.167e-10 1.00
MP2K2_HUMAN MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 2.404e-10 1.00
BLK_HUMAN BLK Tyrosine-protein kinase Blk 4.077e-10 1.00
BTK_HUMAN BTK Tyrosine-protein kinase BTK 1.125e-09 1.00
JAK3_HUMAN JAK3 Tyrosine-protein kinase JAK3 2.938e-09 1.00
FRK_HUMAN FRK Tyrosine-protein kinase FRK 3.001e-09 1.00
SLK_HUMAN SLK STE20-like serine/threonine-protein kinase 8.773e-09 1.00
M3K20_HUMAN MAP3K20 Mitogen-activated protein kinase kinase kinase 20 1.912e-08 1.00
ST17A_HUMAN STK17A Serine/threonine-protein kinase 17A 3.65e-08 1.00
KC1E_HUMAN CSNK1E Casein kinase I isoform epsilon 5.838e-08 1.00
HCK_HUMAN HCK Tyrosine-protein kinase HCK 7.097e-08 1.00
MERTK_HUMAN MERTK Tyrosine-protein kinase Mer 1.542e-07 1.00
WEE1_HUMAN WEE1 Wee1-like protein kinase 2.365e-07 1.00
KPCD_HUMAN PRKCD Protein kinase C delta type 7.055e-07 1.00
UFO_HUMAN AXL Tyrosine-protein kinase receptor UFO 7.171e-07 1.00
ABL1_HUMAN ABL1 Tyrosine-protein kinase ABL1 7.482e-07 1.00
NEK2_HUMAN NEK2 Serine/threonine-protein kinase Nek2 1.06e-06 1.00
KS6A2_HUMAN RPS6KA2 Ribosomal protein S6 kinase alpha-2 1.438e-06 1.00
PAK1_HUMAN PAK1 Serine/threonine-protein kinase PAK 1 1.587e-06 1.00
M4K5_HUMAN MAP4K5 Mitogen-activated protein kinase kinase kinase kinase 5 2.28e-06 1.00
TNI3K_HUMAN TNNI3K Serine/threonine-protein kinase TNNI3K 3.583e-06 1.00
CLK1_HUMAN CLK1 Dual specificity protein kinase CLK1 6.999e-06 1.00
STK3_HUMAN STK3 Serine/threonine-protein kinase 3 9.02e-06 1.00
TIE2_HUMAN TEK Angiopoietin-1 receptor 9.406e-06 1.00
LCK_HUMAN LCK Tyrosine-protein kinase Lck 1.91e-05 1.00
ITK_HUMAN ITK Tyrosine-protein kinase ITK/TSK 2.316e-05 1.00
ACK1_HUMAN TNK2 Activated CDC42 kinase 1 4.669e-05 1.00
CHK1_HUMAN CHEK1 Serine/threonine-protein kinase Chk1 0.0001118 1.00
EPHB4_HUMAN EPHB4 Ephrin type-B receptor 4 0.0002278 1.00
M4K4_HUMAN MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4 0.0002625 1.00
NEK1_HUMAN NEK1 Serine/threonine-protein kinase Nek1 0.0005223 1.00
DAPK3_HUMAN DAPK3 Death-associated protein kinase 3 0.0005991 1.00
TYRO3_HUMAN TYRO3 Tyrosine-protein kinase receptor TYRO3 0.0008773 1.00
DYR1B_HUMAN DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.0009664 1.00
KC1D_HUMAN CSNK1D Casein kinase I isoform delta 0.004132 1.00
CLK2_HUMAN CLK2 Dual specificity protein kinase CLK2 0.006422 1.00
FLT3_HUMAN FLT3 Receptor-type tyrosine-protein kinase FLT3 0.01245 1.00
FAK1_HUMAN PTK2 Focal adhesion kinase 1 0.01947 1.00
MET_HUMAN MET Hepatocyte growth factor receptor 0.03969 1.00
CLK4_HUMAN CLK4 Dual specificity protein kinase CLK4 0.04119 1.00
ALK_HUMAN ALK ALK tyrosine kinase receptor 0.1078 1.00
KSYK_HUMAN SYK Tyrosine-protein kinase SYK 0.2999 1.00
JAK2_HUMAN JAK2 Tyrosine-protein kinase JAK2 0.9941 1.00
M3K8_HUMAN MAP3K8 Mitogen-activated protein kinase kinase kinase 8 3.468e-166 0.50
ERBB4_HUMAN ERBB4 Receptor tyrosine-protein kinase erbB-4 2.354e-98 0.75
MELK_HUMAN MELK Maternal embryonic leucine zipper kinase 1.637e-85 0.75
SRC_RAT Src Proto-oncogene tyrosine-protein kinase Src 9.722e-70 0.37
DUS2L_HUMAN DUS2 tRNA-dihydrouridine(20) synthase [NAD(P)+]-like 2.106e-55 0.44
F16P1_PIG FBP1 Fructose-1,6-bisphosphatase 1 4.947e-40 0.42
ERBB3_HUMAN ERBB3 Receptor tyrosine-protein kinase erbB-3 1.17e-32 0.75
MAST1_HUMAN MAST1 Microtubule-associated serine/threonine-protein kinase 1 1.896e-27 0.75
NEK3_HUMAN NEK3 Serine/threonine-protein kinase Nek3 9.695e-27 0.75
STK39_RAT Stk39 STE20/SPS1-related proline-alanine-rich protein kinase 6.101e-22 0.32
EPHB6_HUMAN EPHB6 Ephrin type-B receptor 6 2.986e-21 0.75
M3K3_HUMAN MAP3K3 Mitogen-activated protein kinase kinase kinase 3 5.331e-20 0.75
DUSTY_HUMAN DSTYK Dual serine/threonine and tyrosine protein kinase 7.811e-20 0.75
MP2K5_HUMAN MAP2K5 Dual specificity mitogen-activated protein kinase kinase 5 8.262e-20 0.75
M3K13_HUMAN MAP3K13 Mitogen-activated protein kinase kinase kinase 13 3.139e-19 0.75
STK35_HUMAN STK35 Serine/threonine-protein kinase 35 1.136e-18 0.75
BLK_MOUSE Blk Tyrosine-protein kinase Blk 3.758e-18 0.35
M3K2_HUMAN MAP3K2 Mitogen-activated protein kinase kinase kinase 2 4.463e-18 0.75
SBK1_HUMAN SBK1 Serine/threonine-protein kinase SBK1 2.824e-17 0.54
VRK2_HUMAN VRK2 Serine/threonine-protein kinase VRK2 8.882e-16 0.35
SIK1_HUMAN SIK1 Serine/threonine-protein kinase SIK1 4.885e-15 0.75
PAK6_HUMAN PAK6 Serine/threonine-protein kinase PAK 6 9.992e-15 0.75
MK04_HUMAN MAPK4 Mitogen-activated protein kinase 4 1.876e-14 0.32
INSRR_HUMAN INSRR Insulin receptor-related protein 3.098e-14 0.75
PAK2_HUMAN PAK2 Serine/threonine-protein kinase PAK 2 3.497e-14 0.75
STK26_HUMAN STK26 Serine/threonine-protein kinase 26 3.497e-14 0.75
M3K19_HUMAN MAP3K19 Mitogen-activated protein kinase kinase kinase 19 6.902e-13 0.75
NUAK1_HUMAN NUAK1 NUAK family SNF1-like kinase 1 2.038e-12 0.75
FA11_HUMAN F11 Coagulation factor XI 2.203e-12 0.34
KS6A6_HUMAN RPS6KA6 Ribosomal protein S6 kinase alpha-6 2.953e-12 0.54
NEK11_HUMAN NEK11 Serine/threonine-protein kinase Nek11 8.383e-12 0.35
IGF1R_HUMAN IGF1R Insulin-like growth factor 1 receptor 1.003e-11 0.75
DYR1A_MOUSE Dyrk1a Dual specificity tyrosine-phosphorylation-regulated kinase 1A 2.335e-11 0.33
T23O_HUMAN TDO2 Tryptophan 2,3-dioxygenase 4.696e-11 0.33
P2RX3_HUMAN P2RX3 P2X purinoceptor 3 1.587e-10 0.35
RS27_HUMAN RPS27 40S ribosomal protein S27 1.621e-10 0.28
MCHR2_HUMAN MCHR2 Melanin-concentrating hormone receptor 2 2.392e-10 0.31
M3K11_HUMAN MAP3K11 Mitogen-activated protein kinase kinase kinase 11 4.938e-10 0.75
KLKB1_HUMAN KLKB1 Plasma kallikrein 5.659e-10 0.34
RIPK2_HUMAN RIPK2 Receptor-interacting serine/threonine-protein kinase 2 6.679e-10 0.54
HSP12_CAEEL hsp-16.2 Heat shock protein Hsp-16.2 9.638e-10 0.28
TLK2_HUMAN TLK2 Serine/threonine-protein kinase tousled-like 2 1.032e-09 0.35
MK06_HUMAN MAPK6 Mitogen-activated protein kinase 6 1.917e-09 0.32
CSKP_HUMAN CASK Peripheral plasma membrane protein CASK 3.266e-09 0.35
MYO3A_HUMAN MYO3A Myosin-IIIa 3.266e-09 0.35
STK39_HUMAN STK39 STE20/SPS1-related proline-alanine-rich protein kinase 3.266e-09 0.35
M3K9_HUMAN MAP3K9 Mitogen-activated protein kinase kinase kinase 9 5.153e-09 0.75
EPHB3_HUMAN EPHB3 Ephrin type-B receptor 3 5.57e-09 0.35
NLK_HUMAN NLK Serine/threonine-protein kinase NLK 7.622e-09 0.35
MYO3B_HUMAN MYO3B Myosin-IIIb 8.923e-09 0.35
ST32A_HUMAN STK32A Serine/threonine-protein kinase 32A 8.923e-09 0.35
EPHA1_HUMAN EPHA1 Ephrin type-A receptor 1 1.541e-08 0.35
SMN_HUMAN SMN1; SMN2 Survival motor neuron protein 1.579e-08 0.30
UBP47_HUMAN USP47 Ubiquitin carboxyl-terminal hydrolase 47 1.857e-08 0.32
SIK3_HUMAN SIK3 Serine/threonine-protein kinase SIK3 2.164e-08 0.35
TLK1_HUMAN TLK1 Serine/threonine-protein kinase tousled-like 1 2.164e-08 0.35
MALT1_HUMAN MALT1 Mucosa-associated lymphoid tissue lymphoma translocation protein 1 2.575e-08 0.33
M3K10_HUMAN MAP3K10 Mitogen-activated protein kinase kinase kinase 10 3.223e-08 0.75
HUNK_HUMAN HUNK Hormonally up-regulated neu tumor-associated kinase 4.756e-08 0.35
M3K1_HUMAN MAP3K1 Mitogen-activated protein kinase kinase kinase 1 4.756e-08 0.35
NIM1_HUMAN NIM1K Serine/threonine-protein kinase NIM1 4.756e-08 0.35
CSK21_HUMAN CSNK2A1 Casein kinase II subunit alpha 6.992e-08 0.35
CDK15_HUMAN CDK15 Cyclin-dependent kinase 15 9.638e-08 0.35
KPCT_HUMAN PRKCQ Protein kinase C theta type 3.22e-07 0.35
TAOK3_HUMAN TAOK3 Serine/threonine-protein kinase TAO3 6.523e-07 0.75
CDK14_HUMAN CDK14 Cyclin-dependent kinase 14 8.964e-07 0.35
MP2K6_HUMAN MAP2K6 Dual specificity mitogen-activated protein kinase kinase 6 8.964e-07 0.35
I23O1_HUMAN IDO1 Indoleamine 2,3-dioxygenase 1 1.488e-06 0.33
ANKK1_HUMAN ANKK1 Ankyrin repeat and protein kinase domain-containing protein 1 2.12e-06 0.35
PI51A_HUMAN PIP5K1A Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha 2.12e-06 0.35
HIPK4_HUMAN HIPK4 Homeodomain-interacting protein kinase 4 2.253e-06 0.75
IRAK1_HUMAN IRAK1 Interleukin-1 receptor-associated kinase 1 2.576e-06 0.75
LRRK2_HUMAN LRRK2 Leucine-rich repeat serine/threonine-protein kinase 2 3.477e-06 0.35
RIOK1_HUMAN RIOK1 Serine/threonine-protein kinase RIO1 4.451e-06 0.35
RIOK3_HUMAN RIOK3 Serine/threonine-protein kinase RIO3 4.451e-06 0.35
ULK3_HUMAN ULK3 Serine/threonine-protein kinase ULK3 4.451e-06 0.35
KPCD1_HUMAN PRKD1 Serine/threonine-protein kinase D1 4.467e-06 0.75
BMPR2_HUMAN BMPR2 Bone morphogenetic protein receptor type-2 6.217e-06 0.35
SRPK3_HUMAN SRPK3 SRSF protein kinase 3 6.217e-06 0.35
RON_HUMAN MST1R Macrophage-stimulating protein receptor 7.977e-06 0.75
GRK4_HUMAN GRK4 G protein-coupled receptor kinase 4 8.504e-06 0.35

Digoxin

AT1A1_HUMAN ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 3.135e-150 1.00
AT1A3_RAT Atp1a3 Sodium/potassium-transporting ATPase subunit alpha-3 9.481e-131 1.00
AT1A2_RAT Atp1a2 Sodium/potassium-transporting ATPase subunit alpha-2 2.753e-118 1.00
AT1A1_CANLF ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 1.596e-97 1.00
AT1A4_RAT Atp1a4 Sodium/potassium-transporting ATPase subunit alpha-4 2.744e-47 1.00
AT1B1_RAT Atp1b1 Sodium/potassium-transporting ATPase subunit beta-1 2.744e-47 1.00
SO1A4_RAT Slco1a4 Solute carrier organic anion transporter family member 1A4 6.524e-44 1.00
RORG_MOUSE Rorc Nuclear receptor ROR-gamma 1.722e-07 1.00
PAX8_HUMAN PAX8 Paired box protein Pax-8 1.915e-07 1.00
STAT3_HUMAN STAT3 Signal transducer and activator of transcription 3 1.064e-05 1.00
RORG_HUMAN RORC Nuclear receptor ROR-gamma 0.02798 1.00
NOTC1_MOUSE Notch1 Neurogenic locus notch homolog protein 1 1.035e-119 0.67
SO4C1_HUMAN SLCO4C1 Solute carrier organic anion transporter family member 4C1 1.975e-89 0.81
AT1B3_RAT Atp1b3 Sodium/potassium-transporting ATPase subunit beta-3 1.061e-54 0.44
AT1A1_PIG ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 4.509e-49 0.32
AT1A1_RAT Atp1a1 Sodium/potassium-transporting ATPase subunit alpha-1 4.512e-35 0.44
AT12A_HUMAN ATP12A Potassium-transporting ATPase alpha chain 2 5.324e-35 0.50
NMDE3_HUMAN GRIN2C Glutamate receptor ionotropic, NMDA 2C 1.006e-17 0.28
NOTC1_HUMAN NOTCH1 Neurogenic locus notch homolog protein 1 1.11e-15 0.38
NMDE4_HUMAN GRIN2D Glutamate receptor ionotropic, NMDA 2D 8.105e-15 0.28
KLF5_HUMAN KLF5 Krueppel-like factor 5 1.88e-06 0.44

AS1517499

STAT6_HUMAN STAT6 Signal transducer and activator of transcription 6 9.388e-150 1.00
PDE5A_CANLF PDE5A cGMP-specific 3',5'-cyclic phosphodiesterase 3.775e-64 0.41
KS6B1_HUMAN RPS6KB1 Ribosomal protein S6 kinase beta-1 6.624e-52 0.41
AURKA_HUMAN AURKA Aurora kinase A 2.279e-46 0.41
TF7L2_HUMAN TCF7L2 Transcription factor 7-like 2 9.15e-43 0.36
CTNB1_HUMAN CTNNB1 Catenin beta-1 1.94e-39 0.36
TYRO3_HUMAN TYRO3 Tyrosine-protein kinase receptor TYRO3 2.076e-35 0.37
Q3I4V7_CRYNV CAN2 Carbonic anhydrase 5.675e-35 0.45
TERA_HUMAN VCP Transitional endoplasmic reticulum ATPase 1.798e-33 0.35
PGLD_CAMJE pglD UDP-N-acetylbacillosamine N-acetyltransferase 1.916e-30 0.31
AURKB_HUMAN AURKB Aurora kinase B 1.211e-29 0.42
UBC9_HUMAN UBE2I SUMO-conjugating enzyme UBC9 7.341e-27 0.32
SRC_CHICK SRC Proto-oncogene tyrosine-protein kinase Src 1.288e-24 0.35
CD38_HUMAN CD38 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 8.458e-24 0.33
EZRI_HUMAN EZR Ezrin 1.038e-23 0.30
SMS1_HUMAN SGMS1 Phosphatidylcholine:ceramide cholinephosphotransferase 1 2.577e-23 0.30
PDE6A_BOVIN PDE6A Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha 6.103e-22 0.40
CAN_CANAL NCE103 Carbonic anhydrase 8.287e-22 0.45
MRGX1_HUMAN MRGPRX1 Mas-related G-protein coupled receptor member X1 9.725e-22 0.37
EGFR_MOUSE Egfr Epidermal growth factor receptor 1.858e-20 0.32
SYN1_BOVIN SYN1 Synapsin-1 2.322e-19 0.31
NCOR1_HUMAN NCOR1 Nuclear receptor corepressor 1 2.85e-19 0.33
LYAM3_HUMAN SELP P-selectin 3.656e-19 0.31
GPR39_MOUSE Gpr39 G-protein coupled receptor 39 4.181e-18 0.29
MERTK_HUMAN MERTK Tyrosine-protein kinase Mer 2.908e-17 0.36
P96878_MYCTU Probable transmembrane carbonic anhydrase (Carbonate dehydratase) (Carbonic dehydratase) 1.11e-16 0.45
PGFRB_MOUSE Pdgfrb Platelet-derived growth factor receptor beta 1.11e-16 0.35
PDIA1_HUMAN P4HB Protein disulfide-isomerase 4.441e-16 0.31
CXCR4_RAT Cxcr4 C-X-C chemokine receptor type 4 8.882e-16 0.33
PA_I000X PA Polymerase acidic protein 4.441e-15 0.29
ADRB1_MOUSE Adrb1 Beta-1 adrenergic receptor 6.684e-14 0.29
A4_HUMAN APP Amyloid-beta precursor protein 9.737e-14 0.38
MTCA1_MYCTU mtcA1 Beta-carbonic anhydrase 1 1.074e-13 0.45
PACR_HUMAN ADCYAP1R1 Pituitary adenylate cyclase-activating polypeptide type I receptor 1.301e-13 0.32
JAK3_HUMAN JAK3 Tyrosine-protein kinase JAK3 2.623e-13 0.42
KPCT_HUMAN PRKCQ Protein kinase C theta type 4.888e-13 0.39
TRXR1_HUMAN TXNRD1 Thioredoxin reductase 1, cytoplasmic 5.245e-13 0.32
Q6R7Z5_9TRYP Cathepsin B-like cysteine protease 7.26e-13 0.29
PDE5A_HUMAN PDE5A cGMP-specific 3',5'-cyclic phosphodiesterase 7.44e-13 0.40
AA1R_BOVIN ADORA1 Adenosine receptor A1 1.694e-12 0.31
STAT3_MOUSE Stat3 Signal transducer and activator of transcription 3 3.128e-12 0.36
CDK5_HUMAN CDK5 Cyclin-dependent-like kinase 5 5.555e-12 0.36
A6QR73_RAT Gpr39 G protein-coupled receptor 39 6.966e-12 0.29
HDAC1_HUMAN HDAC1 Histone deacetylase 1 5.305e-11 0.39
SO2A1_RAT Slco2a1 Solute carrier organic anion transporter family member 2A1 6.273e-11 0.30
ADRB2_RAT Adrb2 Beta-2 adrenergic receptor 7.032e-11 0.29
CAH14_HUMAN CA14 Carbonic anhydrase 14 1.008e-10 0.35
CDK1_HUMAN CDK1 Cyclin-dependent kinase 1 1.311e-10 0.36
HD_HUMAN HTT Huntingtin 1.477e-10 0.28
DYR1A_MOUSE Dyrk1a Dual specificity tyrosine-phosphorylation-regulated kinase 1A 1.517e-10 0.31
UFO_HUMAN AXL Tyrosine-protein kinase receptor UFO 1.765e-10 0.36
SCNNA_HUMAN SCNN1A Amiloride-sensitive sodium channel subunit alpha 2.766e-10 0.30
GPR39_HUMAN GPR39 G-protein coupled receptor 39 5.167e-10 0.29
THRB_HUMAN F2 Prothrombin 7.889e-10 0.35
SCN2A_HUMAN SCN2A Sodium channel protein type 2 subunit alpha 9.427e-10 0.30
MTSI_SPISQ sssIM CPG DNA methylase 2.304e-09 0.29
ERM_STREE erm rRNA adenine N-6-methyltransferase 3.189e-09 0.29
PP1A_HUMAN PPP1CA Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 4.181e-09 0.37
CCNE2_HUMAN CCNE2 G1/S-specific cyclin-E2 6.995e-09 0.36
ERCC1_HUMAN ERCC1 DNA excision repair protein ERCC-1 7.348e-09 0.31
XPF_HUMAN ERCC4 DNA repair endonuclease XPF 7.348e-09 0.31
KSYK_HUMAN SYK Tyrosine-protein kinase SYK 7.419e-09 0.48
CD5R1_HUMAN CDK5R1 Cyclin-dependent kinase 5 activator 1 8.123e-09 0.32
CCNE1_HUMAN CCNE1 G1/S-specific cyclin-E1 8.865e-09 0.36
SAE2_HUMAN UBA2 SUMO-activating enzyme subunit 2 9.953e-09 0.32
SAE1_HUMAN SAE1 SUMO-activating enzyme subunit 1 1.25e-08 0.32
CCNH_HUMAN CCNH Cyclin-H 1.469e-08 0.31
ZAP70_HUMAN ZAP70 Tyrosine-protein kinase ZAP-70 1.674e-08 0.42
HDAC2_HUMAN HDAC2 Histone deacetylase 2 1.733e-08 0.39
MAP11_HUMAN METAP1 Methionine aminopeptidase 1 3.365e-08 0.33
CAH13_HUMAN CA13 Carbonic anhydrase 13 3.839e-08 0.36
CASR_HUMAN CASR Extracellular calcium-sensing receptor 3.913e-08 0.36
DPOL_HHV6U U38 DNA polymerase catalytic subunit 3.985e-08 0.29
CAH3_HUMAN CA3 Carbonic anhydrase 3 4.106e-08 0.34
SYK_HUMAN KARS1 Lysine--tRNA ligase 5.255e-08 0.40
HDAC3_HUMAN HDAC3 Histone deacetylase 3 6.902e-08 0.39
CDK7_HUMAN CDK7 Cyclin-dependent kinase 7 7.179e-08 0.33
NR1H3_HUMAN NR1H3 Oxysterols receptor LXR-alpha 7.613e-08 0.35
AGTRA_RAT Agtr1 Type-1A angiotensin II receptor 9.678e-08 0.35
A0A0C7ACN7_PSEAI pqsD 3-oxoacyl-ACP synthase 1.207e-07 0.33
CLK2_HUMAN CLK2 Dual specificity protein kinase CLK2 1.342e-07 0.36
CLK1_HUMAN CLK1 Dual specificity protein kinase CLK1 1.609e-07 0.31
TBB2B_BOVIN TUBB2B Tubulin beta-2B chain 1.911e-07 0.32
MK09_HUMAN MAPK9 Mitogen-activated protein kinase 9 2.15e-07 0.36
NR1H2_HUMAN NR1H2 Oxysterols receptor LXR-beta 2.207e-07 0.35
KDM4E_HUMAN KDM4E Lysine-specific demethylase 4E 2.837e-07 0.33
CSK21_HUMAN CSNK2A1 Casein kinase II subunit alpha 3.073e-07 0.35
KDM6B_HUMAN KDM6B Lysine-specific demethylase 6B 3.539e-07 0.33
FGFR1_HUMAN FGFR1 Fibroblast growth factor receptor 1 3.991e-07 0.35
CLK4_HUMAN CLK4 Dual specificity protein kinase CLK4 4.249e-07 0.38
PDE4B_HUMAN PDE4B cAMP-specific 3',5'-cyclic phosphodiesterase 4B 5.088e-07 0.36
CCNT1_HUMAN CCNT1 Cyclin-T1 5.702e-07 0.36
ADRB2_CANLF ADRB2 Beta-2 adrenergic receptor 6.389e-07 0.29
DYR1A_HUMAN DYRK1A Dual specificity tyrosine-phosphorylation-regulated kinase 1A 6.632e-07 0.36
CDC7_HUMAN CDC7 Cell division cycle 7-related protein kinase 7.606e-07 0.38
PYGM_RABIT PYGM Glycogen phosphorylase, muscle form 1.055e-06 0.34
CAH5A_HUMAN CA5A Carbonic anhydrase 5A, mitochondrial 1.107e-06 0.34
MK10_HUMAN MAPK10 Mitogen-activated protein kinase 10 1.343e-06 0.36
CAH6_HUMAN CA6 Carbonic anhydrase 6 1.615e-06 0.34
CAH9_HUMAN CA9 Carbonic anhydrase 9 2.519e-06 0.35
CDK2_HUMAN CDK2 Cyclin-dependent kinase 2 2.652e-06 0.36
IGF1R_HUMAN IGF1R Insulin-like growth factor 1 receptor 3.074e-06 0.38
PTPRG_HUMAN PTPRG Receptor-type tyrosine-protein phosphatase gamma 3.133e-06 0.28
KDM4D_HUMAN KDM4D Lysine-specific demethylase 4D 3.596e-06 0.33
CAH2_HUMAN CA2 Carbonic anhydrase 2 4.278e-06 0.45
CAH1_HUMAN CA1 Carbonic anhydrase 1 4.585e-06 0.45
MAT1_HUMAN MNAT1 CDK-activating kinase assembly factor MAT1 4.928e-06 0.28
C3SLB7_ECOLX glmU Bifunctional protein GlmU 5.652e-06 0.28
ACES_HUMAN ACHE Acetylcholinesterase 7.342e-06 0.39
DYR_CANAX DFR1 Dihydrofolate reductase 9.472e-06 0.33

Ouabain

AT1B3_RAT Atp1b3 Sodium/potassium-transporting ATPase subunit beta-3 2.9e-124 1.00
AT1A4_RAT Atp1a4 Sodium/potassium-transporting ATPase subunit alpha-4 5.128e-114 1.00
AT1B1_RAT Atp1b1 Sodium/potassium-transporting ATPase subunit beta-1 5.128e-114 1.00
AT1A3_RAT Atp1a3 Sodium/potassium-transporting ATPase subunit alpha-3 2.326e-91 1.00
AT1A2_RAT Atp1a2 Sodium/potassium-transporting ATPase subunit alpha-2 1.133e-82 1.00
AT1A1_RAT Atp1a1 Sodium/potassium-transporting ATPase subunit alpha-1 2.714e-79 1.00
KLF5_HUMAN KLF5 Krueppel-like factor 5 3.879e-12 1.00
STAT3_HUMAN STAT3 Signal transducer and activator of transcription 3 7.033e-05 1.00
CP2D6_HUMAN CYP2D6 Cytochrome P450 2D6 0.7197 1.00
KCNH2_HUMAN KCNH2 Potassium voltage-gated channel subfamily H member 2 0.9999 1.00
NOTC1_MOUSE Notch1 Neurogenic locus notch homolog protein 1 5.745e-80 0.46
AT1A1_CANLF ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 4.439e-78 0.47
AT1A1_HUMAN ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 1.207e-69 0.44
AT1A1_PIG ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 2.457e-54 0.34
SO4C1_HUMAN SLCO4C1 Solute carrier organic anion transporter family member 4C1 8.579e-52 0.47
SO1A4_RAT Slco1a4 Solute carrier organic anion transporter family member 1A4 1.289e-19 0.44
NOTC1_HUMAN NOTCH1 Neurogenic locus notch homolog protein 1 3.331e-16 0.39
AT12A_HUMAN ATP12A Potassium-transporting ATPase alpha chain 2 6.747e-11 0.42
PAX8_HUMAN PAX8 Paired box protein Pax-8 1.052e-06 0.72

Pracinostat (SB-939)

HDAC1_HUMAN HDAC1 Histone deacetylase 1 6.875e-121 1.00
HDAC8_HUMAN HDAC8 Histone deacetylase 8 6.773e-80 1.00
HDA11_HUMAN HDAC11 Histone deacetylase 11 6.783e-64 1.00
HDAC9_HUMAN HDAC9 Histone deacetylase 9 2.509e-53 1.00
HDAC5_HUMAN HDAC5 Histone deacetylase 5 2.668e-53 1.00
HDAC6_HUMAN HDAC6 Histone deacetylase 6 1.013e-52 1.00
HDAC7_HUMAN HDAC7 Histone deacetylase 7 2.372e-39 1.00
HDA10_HUMAN HDAC10 Polyamine deacetylase HDAC10 4.854e-39 1.00
HDAC2_HUMAN HDAC2 Histone deacetylase 2 4.034e-36 1.00
HDAC4_HUMAN HDAC4 Histone deacetylase 4 4.98e-28 1.00
HDAC3_HUMAN HDAC3 Histone deacetylase 3 8.725e-19 1.00
Q9ZTP8_MAIZE hd1b Histone deacetylase 1.854e-72 0.34
Q94F81_MAIZE hda106 HD2 type histone deacetylase HDA106 1.966e-66 0.34
AGTRA_RAT Agtr1 Type-1A angiotensin II receptor 2.079e-43 0.38
HDAC1_MOUSE Hdac1 Histone deacetylase 1 9.112e-26 0.32
AGTR1_BOVIN AGTR1 Type-1 angiotensin II receptor 3.957e-20 0.36
A8K2H7_HUMAN C3AR1 Complement component 3a receptor 1, isoform CRA_a 1.518e-18 0.36
RAGE_HUMAN AGER Advanced glycosylation end product-specific receptor 9.312e-18 0.34
AGTRB_RAT Agtr1b Type-1B angiotensin II receptor 6.661e-16 0.38
OPRM_MACMU OPRM1 Mu-type opioid receptor 3.22e-15 0.38
TLR7_HUMAN TLR7 Toll-like receptor 7 1.085e-13 0.32
SO1A4_RAT Slco1a4 Solute carrier organic anion transporter family member 1A4 6.588e-13 0.28
TRPM2_HUMAN TRPM2 Transient receptor potential cation channel subfamily M member 2 7.311e-13 0.32
ICMT_HUMAN ICMT Protein-S-isoprenylcysteine O-methyltransferase 6.322e-11 0.31
KCNK2_HUMAN KCNK2 Potassium channel subfamily K member 2 1.441e-10 0.33
TOP2A_HUMAN TOP2A DNA topoisomerase 2-alpha 1.98e-10 0.32
SMCA2_HUMAN SMARCA2 Probable global transcription activator SNF2L2 7.417e-09 0.29
TLR8_HUMAN TLR8 Toll-like receptor 8 5.484e-08 0.33
MCHR1_HUMAN MCHR1 Melanin-concentrating hormone receptor 1 9.762e-08 0.36

Chidamide (Tucidinostat)

HDAC1_HUMAN HDAC1 Histone deacetylase 1 8.363e-107 1.00
NCOR1_HUMAN NCOR1 Nuclear receptor corepressor 1 1.251e-109 0.47
HDAC2_HUMAN HDAC2 Histone deacetylase 2 8.662e-65 0.86
HDAC1_MOUSE Hdac1 Histone deacetylase 1 8.288e-64 0.50
NAMPT_HUMAN NAMPT Nicotinamide phosphoribosyltransferase 6.161e-61 0.58
HDAC3_HUMAN HDAC3 Histone deacetylase 3 4.377e-53 0.52
TF7L2_HUMAN TCF7L2 Transcription factor 7-like 2 4.156e-49 0.34
CTNB1_HUMAN CTNNB1 Catenin beta-1 2.747e-45 0.34
SENP2_HUMAN SENP2 Sentrin-specific protease 2 1.796e-41 0.33
SENP1_HUMAN SENP1 Sentrin-specific protease 1 2.304e-37 0.34
NCOR2_HUMAN NCOR2 Nuclear receptor corepressor 2 9.347e-37 0.44
CP1B1_HUMAN CYP1B1 Cytochrome P450 1B1 3.528e-36 0.42
PTAFR_HUMAN PTAFR Platelet-activating factor receptor 5.996e-24 0.37
T23O_RAT Tdo2 Tryptophan 2,3-dioxygenase 1.577e-23 0.33
NAMPT_RAT Nampt Nicotinamide phosphoribosyltransferase 2.063e-23 0.29
STABP_HUMAN STAMBP STAM-binding protein 3.231e-22 0.34
NAMPT_MOUSE Nampt Nicotinamide phosphoribosyltransferase 9.544e-21 0.38
SCN9A_RAT Scn9a Sodium channel protein type 9 subunit alpha 7.938e-20 0.34
STA5A_HUMAN STAT5A Signal transducer and activator of transcription 5A 1.071e-19 0.31
KCNQ2_MOUSE Kcnq2 Potassium voltage-gated channel subfamily KQT member 2 1.561e-19 0.35
SO2A1_RAT Slco2a1 Solute carrier organic anion transporter family member 2A1 2.781e-18 0.32
STA5B_HUMAN STAT5B Signal transducer and activator of transcription 5B 1.133e-17 0.31
HPSE_HUMAN HPSE Heparanase 4.728e-17 0.33
SIR3_HUMAN SIRT3 NAD-dependent protein deacetylase sirtuin-3, mitochondrial 2.953e-14 0.40
ROCK2_HUMAN ROCK2 Rho-associated protein kinase 2 1.426e-13 0.33
HDAC8_HUMAN HDAC8 Histone deacetylase 8 2.914e-13 0.57
KCNQ2_RAT Kcnq2 Potassium voltage-gated channel subfamily KQT member 2 3.041e-13 0.29
T23O_MOUSE Tdo2 Tryptophan 2,3-dioxygenase 1.458e-12 0.33
LDLR_HUMAN LDLR Low-density lipoprotein receptor 3.05e-12 0.30
PGFRA_HUMAN PDGFRA Platelet-derived growth factor receptor alpha 4.3e-12 0.41
CP27B_MOUSE Cyp27b1 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial 1.078e-11 0.30
HDAC6_HUMAN HDAC6 Histone deacetylase 6 1.137e-11 0.86
PGFRB_RAT Pdgfrb Platelet-derived growth factor receptor beta 5.82e-11 0.29
LYOX_HUMAN LOX Protein-lysine 6-oxidase 5.877e-11 0.29
RIR1_HUMAN RRM1 Ribonucleoside-diphosphate reductase large subunit 8.191e-11 0.29
SIR2_HUMAN SIRT2 NAD-dependent protein deacetylase sirtuin-2 1.906e-10 0.40
Q76353_9HIV1 Integrase 1.161e-09 0.34
ITA4_HUMAN ITGA4 Integrin alpha-4 5.313e-09 0.34
PORCN_MOUSE Porcn Protein-serine O-palmitoleoyltransferase porcupine 6.374e-09 0.32
CSN5_HUMAN COPS5 COP9 signalosome complex subunit 5 1.043e-08 0.29
ITB1_HUMAN ITGB1 Integrin beta-1 1.15e-08 0.34
STXA_SHIDY stxA Shiga toxin subunit A 1.428e-08 0.30
PPBT_BOVIN ALPL Alkaline phosphatase, tissue-nonspecific isozyme 5.258e-08 0.35
HDAC5_HUMAN HDAC5 Histone deacetylase 5 8.436e-08 0.40
HDAC9_HUMAN HDAC9 Histone deacetylase 9 1.471e-07 0.33
PSDE_HUMAN PSMD14 26S proteasome non-ATPase regulatory subunit 14 1.724e-07 0.34
CYSP_PLAFA Trophozoite cysteine proteinase 2.243e-07 0.32
FABH_ENTFA fabH 3-oxoacyl-[acyl-carrier-protein] synthase 3 2.69e-07 0.29
PGFRB_HUMAN PDGFRB Platelet-derived growth factor receptor beta 2.796e-07 0.40
ABL1_HUMAN ABL1 Tyrosine-protein kinase ABL1 3.229e-07 0.40
HDAC7_HUMAN HDAC7 Histone deacetylase 7 4.583e-07 0.33
HDA11_HUMAN HDAC11 Histone deacetylase 11 4.747e-07 0.44
ACOD1_MOUSE Scd1 Acyl-CoA desaturase 1 5.723e-07 0.36
STK11_HUMAN STK11 Serine/threonine-protein kinase STK11 6.39e-07 0.28
PPBI_BOVIN ALPI Intestinal-type alkaline phosphatase 6.582e-07 0.35
BKRB2_CAVPO BDKRB2 B2 bradykinin receptor 1.239e-06 0.32
IMDH2_HUMAN IMPDH2 Inosine-5'-monophosphate dehydrogenase 2 1.604e-06 0.36
SUCR1_HUMAN SUCNR1 Succinate receptor 1 2.049e-06 0.29
PRIO_SHEEP PRNP Major prion protein 2.444e-06 0.29
Q7ZJM1_9HIV1 pol Integrase 3.679e-06 0.33
AMP1_PLAFQ M1 family aminopeptidase 4.528e-06 0.31
LOXL2_HUMAN LOXL2 Lysyl oxidase homolog 2 5.415e-06 0.29
Q76129_9HIV1 gag Structural capsid protein 5.692e-06 0.29
CAH2_BOVIN CA2 Carbonic anhydrase 2 6.696e-06 0.35
LUCI_AQULA Luciferin 4-monooxygenase 7.112e-06 0.29
NEMO_HUMAN IKBKG NF-kappa-B essential modulator 8.279e-06 0.28
MET_HUMAN MET Hepatocyte growth factor receptor 9.319e-06 0.34

Belinostat

HDAC1_HUMAN HDAC1 Histone deacetylase 1 3.077e-106 1.00
HDAC8_HUMAN HDAC8 Histone deacetylase 8 2.417e-87 1.00
HDAC6_HUMAN HDAC6 Histone deacetylase 6 2.779e-59 1.00
HDA11_HUMAN HDAC11 Histone deacetylase 11 3.045e-48 1.00
HDAC9_HUMAN HDAC9 Histone deacetylase 9 8.549e-48 1.00
HDAC2_HUMAN HDAC2 Histone deacetylase 2 6.05e-46 1.00
HDAC5_HUMAN HDAC5 Histone deacetylase 5 7.387e-44 1.00
HDAC4_HUMAN HDAC4 Histone deacetylase 4 1.15e-41 1.00
HDAC7_HUMAN HDAC7 Histone deacetylase 7 2.395e-40 1.00
HDA10_HUMAN HDAC10 Polyamine deacetylase HDAC10 3.374e-32 1.00
Q9XYC7_PLAFA HDAC1 Histone deacetylase 1.517e-27 1.00
HDAC3_HUMAN HDAC3 Histone deacetylase 3 7.654e-24 1.00
BRD4_HUMAN BRD4 Bromodomain-containing protein 4 0.001215 1.00
Q9ZTP8_MAIZE hd1b Histone deacetylase 1.66e-94 0.40
Q94F81_MAIZE hda106 HD2 type histone deacetylase HDA106 5.166e-90 0.43
QCR7_HUMAN UQCRB Cytochrome b-c1 complex subunit 7 1.839e-50 0.37
ARY2_MOUSE Nat2 Arylamine N-acetyltransferase 2 3.876e-48 0.34
SENP2_HUMAN SENP2 Sentrin-specific protease 2 2.088e-47 0.38
SENP1_HUMAN SENP1 Sentrin-specific protease 1 3.147e-42 0.38
DAPAT_ARATH DAP LL-diaminopimelate aminotransferase, chloroplastic 2.89e-41 0.33
O93874_COCLU 17HSDcl 17beta-hydroxysteroid dehydrogenase 9.617e-41 0.32
ARY1_HUMAN NAT1 Arylamine N-acetyltransferase 1 3.409e-40 0.34
RCOR3_HUMAN RCOR3 REST corepressor 3 6.694e-38 0.30
C5ISA2_SHEEP TUBA4A Tubulin alpha chain 8.858e-37 0.29
HDAC1_MOUSE Hdac1 Histone deacetylase 1 1.15e-36 0.42
Q7K6A1_PLAF7 Histone deacetylase 3.307e-36 0.30
LIMK2_HUMAN LIMK2 LIM domain kinase 2 4.995e-32 0.38
Q26964_TRYCR TCTS-154 Trans-sialidase 1.944e-31 0.39
RHOA_HUMAN RHOA Transforming protein RhoA 6.431e-31 0.38
NAMPT_HUMAN NAMPT Nicotinamide phosphoribosyltransferase 4.278e-28 0.41
MMP1_HUMAN MMP1 Interstitial collagenase 2.453e-24 0.50
MMP9_HUMAN MMP9 Matrix metalloproteinase-9 2.6e-24 0.50
MYOC_HUMAN MYOC Myocilin 1.734e-23 0.29
TNI3K_HUMAN TNNI3K Serine/threonine-protein kinase TNNI3K 2.441e-23 0.35
MMP2_HUMAN MMP2 72 kDa type IV collagenase 2.169e-22 0.50
A0A060INS8_CAPHI CTSH Cathepsin H 3.208e-22 0.34
TRPM8_RAT Trpm8 Transient receptor potential cation channel subfamily M member 8 5.003e-22 0.39
PE2R3_HUMAN PTGER3 Prostaglandin E2 receptor EP3 subtype 5.051e-22 0.33
POLG_DEN2P Genome polyprotein 1.142e-20 0.33
F264_HUMAN PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 4.269e-20 0.36
MALX3_YEAST IMA1 Oligo-1,6-glucosidase IMA1 1.575e-19 0.38
STXA_SHIDY stxA Shiga toxin subunit A 1.689e-19 0.40
Q5VLE3_EMEND rmtA RmtA 2.322e-19 0.31
P3C2G_HUMAN PIK3C2G Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma 3.073e-18 0.32
H9B8T9_CAPHI CTSB Cathepsin B 3.203e-18 0.31
AMD_HUMAN PAM Peptidyl-glycine alpha-amidating monooxygenase 4.216e-18 0.30
Q548M1_ECOLX groL 60 kDa chaperonin 1.928e-17 0.33
Q7BGE6_ECOLX groES 10 kDa chaperonin 1.928e-17 0.33
F16P1_HUMAN FBP1 Fructose-1,6-bisphosphatase 1 2.582e-17 0.32
DHB2_HUMAN HSD17B2 Estradiol 17-beta-dehydrogenase 2 5.435e-17 0.38
BXA1_CLOBO botA Botulinum neurotoxin type A 1.11e-16 0.38
CAH4_BOVIN CA4 Carbonic anhydrase 4 1.11e-16 0.39
A5H660_SCHMA HDAC8 Histone deacetylase 8 4.441e-16 0.32
F263_HUMAN PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 1.443e-15 0.46
DHB1_HUMAN HSD17B1 Estradiol 17-beta-dehydrogenase 1 2.22e-15 0.36
PMM2_HUMAN PMM2 Phosphomannomutase 2 2.665e-15 0.32
AOFB_HUMAN MAOB Amine oxidase [flavin-containing] B 2.776e-15 0.51
GP183_HUMAN GPR183 G-protein coupled receptor 183 1.177e-14 0.32
LOX12_HUMAN ALOX12 Arachidonate 12-lipoxygenase, 12S-type 1.188e-14 0.38
MEP1B_HUMAN MEP1B Meprin A subunit beta 1.987e-14 0.36
EAA2_HUMAN SLC1A2 Excitatory amino acid transporter 2 3.02e-14 0.30
KCNQ2_MOUSE Kcnq2 Potassium voltage-gated channel subfamily KQT member 2 4.53e-14 0.33
AK1C3_HUMAN AKR1C3 Aldo-keto reductase family 1 member C3 4.863e-14 0.42
IMDH1_HUMAN IMPDH1 Inosine-5'-monophosphate dehydrogenase 1 7.361e-14 0.41
MGAT1_HUMAN MGAT1 Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase 9.115e-14 0.34
PFKA_TRYCC pfk ATP-dependent 6-phosphofructokinase 9.237e-14 0.31
PPBT_BOVIN ALPL Alkaline phosphatase, tissue-nonspecific isozyme 2.177e-13 0.40
PFKA_TRYBB pfk ATP-dependent 6-phosphofructokinase 7.514e-13 0.31
MGAT2_MOUSE Mgat2 Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase 1.624e-12 0.34
IMDH2_HUMAN IMPDH2 Inosine-5'-monophosphate dehydrogenase 2 8.305e-12 0.41
TRPM2_HUMAN TRPM2 Transient receptor potential cation channel subfamily M member 2 9.7e-12 0.29
RBBP9_HUMAN RBBP9 Serine hydrolase RBBP9 2.665e-11 0.30
MCL1_HUMAN MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 2.677e-11 0.37
TYSY_ECOLI thyA Thymidylate synthase 5.477e-11 0.35
CAH2_HUMAN CA2 Carbonic anhydrase 2 5.519e-11 0.42
P96830_MYCTO TYR_PHOSPHATASE_2 domain-containing protein 5.973e-11 0.30
TTHY_HUMAN TTR Transthyretin 9.478e-11 0.32
RT109_YEAST RTT109 Histone acetyltransferase RTT109 1.167e-10 0.31
GGPPS_YEAST BTS1 Geranylgeranyl pyrophosphate synthase 1.517e-10 0.31
EAA1_HUMAN SLC1A3 Excitatory amino acid transporter 1 3.015e-10 0.30
LIPL_RAT Lpl Lipoprotein lipase 3.195e-10 0.39
CAH1_HUMAN CA1 Carbonic anhydrase 1 3.816e-10 0.42
PPBI_BOVIN ALPI Intestinal-type alkaline phosphatase 4.5e-10 0.40
PRGR_HUMAN PGR Progesterone receptor 4.703e-10 0.50
PAR15_HUMAN PARP15 Protein mono-ADP-ribosyltransferase PARP15 7.541e-10 0.29
AK1A1_RAT Akr1a1 Aldo-keto reductase family 1 member A1 9.421e-10 0.33
NMDZ1_RAT Grin1 Glutamate receptor ionotropic, NMDA 1 1.261e-09 0.36
P3C2B_HUMAN PIK3C2B Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta 2.735e-09 0.32
DHB3_RAT Hsd17b3 Testosterone 17-beta-dehydrogenase 3 2.744e-09 0.37
CHLE_HUMAN BCHE Cholinesterase 4.992e-09 0.36
P90584_PLAFA Pfmrk MO15-related protein kinase Pfmrk 6.576e-09 0.33
FACE2_HUMAN RCE1 CAAX prenyl protease 2 1.012e-08 0.44
HPSE_HUMAN HPSE Heparanase 1.21e-08 0.31
NR0B1_HUMAN NR0B1 Nuclear receptor subfamily 0 group B member 1 1.709e-08 0.30
CLTR1_HUMAN CYSLTR1 Cysteinyl leukotriene receptor 1 1.741e-08 0.30
LT4R1_HUMAN LTB4R Leukotriene B4 receptor 1 1.777e-08 0.42
MGAT3_HUMAN MGAT3 Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase 3.354e-08 0.34
LOX5_RAT Alox5 Arachidonate 5-lipoxygenase 4.459e-08 0.49
INSR_MOUSE Insr Insulin receptor 4.633e-08 0.30
CAH12_HUMAN CA12 Carbonic anhydrase 12 7.146e-08 0.46
NF2L2_HUMAN NFE2L2 Nuclear factor erythroid 2-related factor 2 7.516e-08 0.31
KPYM_HUMAN PKM Pyruvate kinase PKM 9.185e-08 0.32
S12A2_HUMAN SLC12A2 Solute carrier family 12 member 2 9.381e-08 0.33
ALDR_RAT Akr1b1 Aldo-keto reductase family 1 member B1 1.155e-07 0.45
ADRB1_HUMAN ADRB1 Beta-1 adrenergic receptor 1.221e-07 0.37
MTNN_ECOLI mtnN 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 1.813e-07 0.31
CAH9_HUMAN CA9 Carbonic anhydrase 9 2.469e-07 0.46
MMP26_HUMAN MMP26 Matrix metalloproteinase-26 2.994e-07 0.28
PI2R_HUMAN PTGIR Prostacyclin receptor 3.926e-07 0.39
S40A1_HUMAN SLC40A1 Solute carrier family 40 member 1 4.052e-07 0.30
MAP2_HUMAN METAP2 Methionine aminopeptidase 2 4.208e-07 0.37
PF2R_HUMAN PTGFR Prostaglandin F2-alpha receptor 4.327e-07 0.31
ADRB3_HUMAN ADRB3 Beta-3 adrenergic receptor 4.996e-07 0.37
PGES2_HUMAN PTGES2 Prostaglandin E synthase 2 5.685e-07 0.33
NCOR2_HUMAN NCOR2 Nuclear receptor corepressor 2 7.951e-07 0.33
ADRB2_HUMAN ADRB2 Beta-2 adrenergic receptor 1.049e-06 0.37
STAT1_HUMAN STAT1 Signal transducer and activator of transcription 1-alpha/beta 1.579e-06 0.40
ACLY_HUMAN ACLY ATP-citrate synthase 1.651e-06 0.30
P4HTM_HUMAN P4HTM Transmembrane prolyl 4-hydroxylase 1.95e-06 0.30
CAH2_BOVIN CA2 Carbonic anhydrase 2 2.013e-06 0.35
PLEC_HUMAN PLEC Plectin 2.856e-06 0.33
GABT_RAT Abat 4-aminobutyrate aminotransferase, mitochondrial 3.101e-06 0.33
PE2R2_HUMAN PTGER2 Prostaglandin E2 receptor EP2 subtype 3.408e-06 0.39
EAA3_HUMAN SLC1A1 Excitatory amino acid transporter 3 3.486e-06 0.29
5HT6R_HUMAN HTR6 5-hydroxytryptamine receptor 6 3.797e-06 0.45
FABP4_HUMAN FABP4 Fatty acid-binding protein, adipocyte 4.182e-06 0.31
KCNQ3_HUMAN KCNQ3 Potassium voltage-gated channel subfamily KQT member 3 4.376e-06 0.33
O49150_SOLTU Lipoxygenase 5.557e-06 0.29
Q8I2J3_PLAF7 M18 aspartyl aminopeptidase 5.63e-06 0.42
S12A5_HUMAN SLC12A5 Solute carrier family 12 member 5 7.334e-06 0.33
MMP15_HUMAN MMP15 Matrix metalloproteinase-15 8.558e-06 0.28
BRPF3_HUMAN BRPF3 Bromodomain and PHD finger-containing protein 3 9.884e-06 0.32

Cerdulatinib

JAK2_HUMAN JAK2 Tyrosine-protein kinase JAK2 4.743e-97 1.00
JAK1_HUMAN JAK1 Tyrosine-protein kinase JAK1 1.195e-89 1.00
JAK3_HUMAN JAK3 Tyrosine-protein kinase JAK3 2.207e-50 1.00
STAT6_HUMAN STAT6 Signal transducer and activator of transcription 6 6.638e-154 0.56
CCND2_HUMAN CCND2 G1/S-specific cyclin-D2 8.144e-143 0.41
CCND3_HUMAN CCND3 G1/S-specific cyclin-D3 3.993e-111 0.42
CCND1_HUMAN CCND1 G1/S-specific cyclin-D1 6.59e-109 0.45
MERTK_HUMAN MERTK Tyrosine-protein kinase Mer 1.274e-106 0.49
TYRO3_HUMAN TYRO3 Tyrosine-protein kinase receptor TYRO3 6.427e-104 0.49
CDK4_HUMAN CDK4 Cyclin-dependent kinase 4 5.269e-96 0.45
ALK_HUMAN ALK ALK tyrosine kinase receptor 4.274e-83 0.50
UFO_HUMAN AXL Tyrosine-protein kinase receptor UFO 2.679e-68 0.49
CDK6_HUMAN CDK6 Cyclin-dependent kinase 6 2.048e-61 0.42
CDK1_HUMAN CDK1 Cyclin-dependent kinase 1 9.288e-54 0.45
CDK2_HUMAN CDK2 Cyclin-dependent kinase 2 9e-53 0.45
C11B2_MOUSE Cyp11b2 Cytochrome P450 11B2, mitochondrial 9.643e-49 0.32
FAK1_HUMAN PTK2 Focal adhesion kinase 1 2.843e-47 0.41
TBK1_MOUSE Tbk1 Serine/threonine-protein kinase TBK1 9.812e-47 0.39
INSR_HUMAN INSR Insulin receptor 5.712e-43 0.41
CCNH_HUMAN CCNH Cyclin-H 8.126e-41 0.36
CSF1R_HUMAN CSF1R Macrophage colony-stimulating factor 1 receptor 1.377e-40 0.47
CCNA2_HUMAN CCNA2 Cyclin-A2 7.649e-40 0.42
CCR7_HUMAN CCR7 C-C chemokine receptor type 7 4.474e-39 0.31
ROS1_HUMAN ROS1 Proto-oncogene tyrosine-protein kinase ROS 1.033e-38 0.50
CDK7_HUMAN CDK7 Cyclin-dependent kinase 7 7.103e-38 0.40
LYAM3_HUMAN SELP P-selectin 8.991e-38 0.41
CCNE2_HUMAN CCNE2 G1/S-specific cyclin-E2 9.236e-38 0.38
INSR_RAT Insr Insulin receptor 1.377e-35 0.28
AURKA_HUMAN AURKA Aurora kinase A 2.177e-33 0.42
CCNB1_HUMAN CCNB1 G2/mitotic-specific cyclin-B1 2.36e-32 0.38
IGF1R_HUMAN IGF1R Insulin-like growth factor 1 receptor 2.761e-32 0.40
JAK3_MOUSE Jak3 Tyrosine-protein kinase JAK3 1.158e-30 0.34
PMYT1_HUMAN PKMYT1 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase 5.731e-30 0.40
TBK1_HUMAN TBK1 Serine/threonine-protein kinase TBK1 5.884e-30 0.40
ACK1_HUMAN TNK2 Activated CDC42 kinase 1 2.287e-29 0.44
AURKB_HUMAN AURKB Aurora kinase B 2.451e-29 0.42
TTK_HUMAN TTK Dual specificity protein kinase TTK 5.945e-29 0.43
GPR6_HUMAN GPR6 G-protein coupled receptor 6 1.064e-28 0.33
WEE2_HUMAN WEE2 Wee1-like protein kinase 2 1.677e-28 0.35
NEK6_HUMAN NEK6 Serine/threonine-protein kinase Nek6 1.836e-28 0.35
KSYK_HUMAN SYK Tyrosine-protein kinase SYK 3.766e-27 0.85
CCNA1_HUMAN CCNA1 Cyclin-A1 1.313e-26 0.38
TSSK2_HUMAN TSSK2 Testis-specific serine/threonine-protein kinase 2 3.985e-26 0.35
M3K7_HUMAN MAP3K7 Mitogen-activated protein kinase kinase kinase 7 9.381e-26 0.43
VGFR3_HUMAN FLT4 Vascular endothelial growth factor receptor 3 1.432e-25 0.35
MK09_HUMAN MAPK9 Mitogen-activated protein kinase 9 1.451e-25 0.47
WEE1_HUMAN WEE1 Wee1-like protein kinase 1.882e-25 0.42
ABL1_MOUSE Abl1 Tyrosine-protein kinase ABL1 2.415e-25 0.30
SNRK_HUMAN SNRK SNF-related serine/threonine-protein kinase 2.981e-25 0.29
MP2K1_MOUSE Map2k1 Dual specificity mitogen-activated protein kinase kinase 1 3.065e-25 0.41
H9YX08_MACMU CCR6 C-C chemokine receptor type 6 3.865e-25 0.31
RIPK1_MOUSE Ripk1 Receptor-interacting serine/threonine-protein kinase 1 6.236e-25 0.29
CHK1_HUMAN CHEK1 Serine/threonine-protein kinase Chk1 1.598e-23 0.42
CCNB2_HUMAN CCNB2 G2/mitotic-specific cyclin-B2 2.296e-23 0.38
CCNB3_HUMAN CCNB3 G2/mitotic-specific cyclin-B3 2.296e-23 0.38
RET_HUMAN RET Proto-oncogene tyrosine-protein kinase receptor Ret 2.78e-23 0.50
MK08_HUMAN MAPK8 Mitogen-activated protein kinase 8 3.373e-23 0.47
TSSK1_HUMAN TSSK1B Testis-specific serine/threonine-protein kinase 1 3.886e-23 0.35
CSKP_HUMAN CASK Peripheral plasma membrane protein CASK 6.027e-23 0.35
ZAP70_HUMAN ZAP70 Tyrosine-protein kinase ZAP-70 7.448e-23 0.41
IKKE_HUMAN IKBKE Inhibitor of nuclear factor kappa-B kinase subunit epsilon 7.466e-23 0.40
CD63_HUMAN CD63 CD63 antigen 8.614e-23 0.29
GSK3A_HUMAN GSK3A Glycogen synthase kinase-3 alpha 2.617e-22 0.40
DCLK1_HUMAN DCLK1 Serine/threonine-protein kinase DCLK1 2.804e-22 0.35
LCK_HUMAN LCK Tyrosine-protein kinase Lck 3.69e-22 0.43
MK07_HUMAN MAPK7 Mitogen-activated protein kinase 7 5.461e-22 0.35
CSF1R_MOUSE Csf1r Macrophage colony-stimulating factor 1 receptor 5.21e-21 0.41
MATK_HUMAN MATK Megakaryocyte-associated tyrosine-protein kinase 5.317e-21 0.35
PLK1_HUMAN PLK1 Serine/threonine-protein kinase PLK1 6.446e-21 0.34
KCC2D_HUMAN CAMK2D Calcium/calmodulin-dependent protein kinase type II subunit delta 1.103e-20 0.37
NEK3_HUMAN NEK3 Serine/threonine-protein kinase Nek3 2.073e-20 0.29
FLT3_HUMAN FLT3 Receptor-type tyrosine-protein kinase FLT3 2.114e-20 0.50
CCNE1_HUMAN CCNE1 G1/S-specific cyclin-E1 3.488e-20 0.39
EGFR_HUMAN EGFR Epidermal growth factor receptor 5.732e-20 0.43
LTK_HUMAN LTK Leukocyte tyrosine kinase receptor 6.856e-20 0.40
CCNT1_HUMAN CCNT1 Cyclin-T1 7.88e-20 0.36
PDE4B_HUMAN PDE4B cAMP-specific 3',5'-cyclic phosphodiesterase 4B 1.232e-19 0.39
DAPK3_HUMAN DAPK3 Death-associated protein kinase 3 1.265e-19 0.40
MAPK5_HUMAN MAPKAPK5 MAP kinase-activated protein kinase 5 1.936e-19 0.33
CDK15_HUMAN CDK15 Cyclin-dependent kinase 15 4.019e-19 0.35
CSK21_HUMAN CSNK2A1 Casein kinase II subunit alpha 4.701e-19 0.38
CDK9_HUMAN CDK9 Cyclin-dependent kinase 9 5.29e-19 0.40
PAK4_HUMAN PAK4 Serine/threonine-protein kinase PAK 4 1.927e-18 0.40
TAOK1_HUMAN TAOK1 Serine/threonine-protein kinase TAO1 2.502e-18 0.40
KCC2A_HUMAN CAMK2A Calcium/calmodulin-dependent protein kinase type II subunit alpha 2.575e-18 0.40
MP2K2_HUMAN MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 2.711e-18 0.40
PRIO_SHEEP PRNP Major prion protein 4.132e-18 0.30
CDC2H_PLAF7 CRK2 Cell division control protein 2 homolog 4.799e-18 0.35
PLK2_HUMAN PLK2 Serine/threonine-protein kinase PLK2 5.359e-18 0.31
PAK1_HUMAN PAK1 Serine/threonine-protein kinase PAK 1 6.09e-18 0.35
SRC_HUMAN SRC Proto-oncogene tyrosine-protein kinase Src 6.631e-18 0.42
M4K2_HUMAN MAP4K2 Mitogen-activated protein kinase kinase kinase kinase 2 7.673e-18 0.40
MK10_HUMAN MAPK10 Mitogen-activated protein kinase 10 7.864e-18 0.47
KPCD3_HUMAN PRKD3 Serine/threonine-protein kinase D3 8.816e-18 0.40
ST32C_HUMAN STK32C Serine/threonine-protein kinase 32C 9.056e-18 0.28
FYN_HUMAN FYN Tyrosine-protein kinase Fyn 1.069e-17 0.40
STK38_HUMAN STK38 Serine/threonine-protein kinase 38 2.008e-17 0.29
VGFR2_HUMAN KDR Vascular endothelial growth factor receptor 2 2.527e-17 0.42
ULK1_HUMAN ULK1 Serine/threonine-protein kinase ULK1 3.345e-17 0.29
CILK1_HUMAN CILK1 Serine/threonine-protein kinase ICK 3.724e-17 0.35
IKKB_HUMAN IKBKB Inhibitor of nuclear factor kappa-B kinase subunit beta 4.852e-17 0.34
CCR6_HUMAN CCR6 C-C chemokine receptor type 6 1.11e-16 0.31
DUSTY_HUMAN DSTYK Dual serine/threonine and tyrosine protein kinase 1.11e-16 0.35
LRRK2_HUMAN LRRK2 Leucine-rich repeat serine/threonine-protein kinase 2 1.11e-16 0.40
ULK2_HUMAN ULK2 Serine/threonine-protein kinase ULK2 1.11e-16 0.29
AAPK1_HUMAN PRKAA1 5'-AMP-activated protein kinase catalytic subunit alpha-1 2.22e-16 0.40
TAOK2_HUMAN TAOK2 Serine/threonine-protein kinase TAO2 2.22e-16 0.35
CLK2_HUMAN CLK2 Dual specificity protein kinase CLK2 3.331e-16 0.40
CDK17_HUMAN CDK17 Cyclin-dependent kinase 17 4.441e-16 0.35
CDKL5_HUMAN CDKL5 Cyclin-dependent kinase-like 5 4.441e-16 0.35
IKKA_HUMAN CHUK Inhibitor of nuclear factor kappa-B kinase subunit alpha 4.441e-16 0.34
PAK5_HUMAN PAK5 Serine/threonine-protein kinase PAK 5 5.551e-16 0.37
MET_HUMAN MET Hepatocyte growth factor receptor 6.661e-16 0.40
NTRK2_HUMAN NTRK2 BDNF/NT-3 growth factors receptor 6.661e-16 0.40
RON_HUMAN MST1R Macrophage-stimulating protein receptor 9.992e-16 0.40
NEK2_HUMAN NEK2 Serine/threonine-protein kinase Nek2 1.11e-15 0.38
Q9WJQ2_9HIV1 reverse transcriptase Reverse transcriptase protein 1.332e-15 0.39
MARK3_HUMAN MARK3 MAP/microtubule affinity-regulating kinase 3 2.22e-15 0.39
NEK9_HUMAN NEK9 Serine/threonine-protein kinase Nek9 2.331e-15 0.29
PLK3_HUMAN PLK3 Serine/threonine-protein kinase PLK3 2.554e-15 0.34
NEK4_HUMAN NEK4 Serine/threonine-protein kinase Nek4 3.22e-15 0.35
ACVR1_HUMAN ACVR1 Activin receptor type-1 3.553e-15 0.40
MYLK2_HUMAN MYLK2 Myosin light chain kinase 2, skeletal/cardiac muscle 5.995e-15 0.40
M3K9_HUMAN MAP3K9 Mitogen-activated protein kinase kinase kinase 9 1.055e-14 0.37
SRMS_HUMAN SRMS Tyrosine-protein kinase Srms 1.055e-14 0.33
MARK1_HUMAN MARK1 Serine/threonine-protein kinase MARK1 1.144e-14 0.29
M4K5_HUMAN MAP4K5 Mitogen-activated protein kinase kinase kinase kinase 5 1.21e-14 0.37
COQ8A_HUMAN COQ8A Atypical kinase COQ8A, mitochondrial 1.499e-14 0.29
STK39_HUMAN STK39 STE20/SPS1-related proline-alanine-rich protein kinase 1.499e-14 0.29
CDPK1_PLAF7 CPK1 Calcium-dependent protein kinase 1 1.854e-14 0.30
DMPK_HUMAN DMPK Myotonin-protein kinase 1.965e-14 0.35
KKCC2_HUMAN CAMKK2 Calcium/calmodulin-dependent protein kinase kinase 2 2.065e-14 0.35
PDE6A_BOVIN PDE6A Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha 3.086e-14 0.29
MP2K1_HUMAN MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 3.164e-14 0.40
M4K4_HUMAN MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4 3.342e-14 0.40
KAPCA_HUMAN PRKACA cAMP-dependent protein kinase catalytic subunit alpha 3.741e-14 0.40
M3K1_HUMAN MAP3K1 Mitogen-activated protein kinase kinase kinase 1 6.484e-14 0.35
KCC1A_HUMAN CAMK1 Calcium/calmodulin-dependent protein kinase type 1 6.928e-14 0.34
JAK2_MOUSE Jak2 Tyrosine-protein kinase JAK2 7.15e-14 0.34
DCLK2_HUMAN DCLK2 Serine/threonine-protein kinase DCLK2 7.638e-14 0.29
DCLK3_HUMAN DCLK3 Serine/threonine-protein kinase DCLK3 9.415e-14 0.35
MK15_HUMAN MAPK15 Mitogen-activated protein kinase 15 9.415e-14 0.35
PKN2_HUMAN PKN2 Serine/threonine-protein kinase N2 1.011e-13 0.37
FER_HUMAN FER Tyrosine-protein kinase Fer 1.147e-13 0.35
NUAK1_HUMAN NUAK1 NUAK family SNF1-like kinase 1 1.286e-13 0.35
ERBB4_HUMAN ERBB4 Receptor tyrosine-protein kinase erbB-4 2.209e-13 0.37
KCC2G_HUMAN CAMK2G Calcium/calmodulin-dependent protein kinase type II subunit gamma 2.388e-13 0.35
COQ8B_HUMAN COQ8B Atypical kinase COQ8B, mitochondrial 3.217e-13 0.29
NEK7_HUMAN NEK7 Serine/threonine-protein kinase Nek7 3.217e-13 0.29
SBK3_HUMAN SBK3 Uncharacterized serine/threonine-protein kinase SBK3 3.217e-13 0.29
SIK3_HUMAN SIK3 Serine/threonine-protein kinase SIK3 3.217e-13 0.29
PGFRA_HUMAN PDGFRA Platelet-derived growth factor receptor alpha 3.397e-13 0.40
BRSK2_HUMAN BRSK2 Serine/threonine-protein kinase BRSK2 3.577e-13 0.39
FAK2_HUMAN PTK2B Protein-tyrosine kinase 2-beta 3.794e-13 0.35
PRKX_HUMAN PRKX cAMP-dependent protein kinase catalytic subunit PRKX 4.439e-13 0.40
CDK18_HUMAN CDK18 Cyclin-dependent kinase 18 5.88e-13 0.35
GP119_MOUSE Gpr119 Glucose-dependent insulinotropic receptor 6.285e-13 0.33
PHKG2_HUMAN PHKG2 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 7.102e-13 0.34
TYK2_HUMAN TYK2 Non-receptor tyrosine-protein kinase TYK2 7.981e-13 0.42
BTK_HUMAN BTK Tyrosine-protein kinase BTK 9.099e-13 0.43
NIM1_HUMAN NIM1K Serine/threonine-protein kinase NIM1 1.155e-12 0.29
PRP4B_HUMAN PRPF4B Serine/threonine-protein kinase PRP4 homolog 1.155e-12 0.29
HIPK2_HUMAN HIPK2 Homeodomain-interacting protein kinase 2 1.433e-12 0.35
BRSK1_HUMAN BRSK1 Serine/threonine-protein kinase BRSK1 1.802e-12 0.35
BLK_HUMAN BLK Tyrosine-protein kinase Blk 1.89e-12 0.35
KC1A_HUMAN CSNK1A1 Casein kinase I isoform alpha 3.382e-12 0.40
GSK3B_HUMAN GSK3B Glycogen synthase kinase-3 beta 4.548e-12 0.39
FES_HUMAN FES Tyrosine-protein kinase Fes/Fps 5.611e-12 0.34
KS6A6_HUMAN RPS6KA6 Ribosomal protein S6 kinase alpha-6 6.289e-12 0.29
KCC1D_HUMAN CAMK1D Calcium/calmodulin-dependent protein kinase type 1D 6.563e-12 0.40
HIPK4_HUMAN HIPK4 Homeodomain-interacting protein kinase 4 6.667e-12 0.35
EPHB3_HUMAN EPHB3 Ephrin type-B receptor 3 6.764e-12 0.29
SLK_HUMAN SLK STE20-like serine/threonine-protein kinase 7.251e-12 0.35
ST17A_HUMAN STK17A Serine/threonine-protein kinase 17A 7.759e-12 0.37
DYR1B_HUMAN DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B 9.385e-12 0.40
KCC1G_HUMAN CAMK1G Calcium/calmodulin-dependent protein kinase type 1G 1.02e-11 0.29
SBK1_HUMAN SBK1 Serine/threonine-protein kinase SBK1 1.02e-11 0.29
CDK14_HUMAN CDK14 Cyclin-dependent kinase 14 1.034e-11 0.35
KS6A3_HUMAN RPS6KA3 Ribosomal protein S6 kinase alpha-3 1.088e-11 0.40
PAK2_HUMAN PAK2 Serine/threonine-protein kinase PAK 2 1.264e-11 0.32
PKN1_HUMAN PKN1 Serine/threonine-protein kinase N1 1.338e-11 0.37
ALK_MOUSE Alk ALK tyrosine kinase receptor 1.437e-11 0.28
M3K6_HUMAN MAP3K6 Mitogen-activated protein kinase kinase kinase 6 1.437e-11 0.28
CLK4_HUMAN CLK4 Dual specificity protein kinase CLK4 1.487e-11 0.40
CDK16_HUMAN CDK16 Cyclin-dependent kinase 16 1.741e-11 0.35
KCC2B_HUMAN CAMK2B Calcium/calmodulin-dependent protein kinase type II subunit beta 2.334e-11 0.35
MARK4_HUMAN MARK4 MAP/microtubule affinity-regulating kinase 4 2.551e-11 0.31
PAK6_HUMAN PAK6 Serine/threonine-protein kinase PAK 6 2.605e-11 0.29
RIPK4_HUMAN RIPK4 Receptor-interacting serine/threonine-protein kinase 4 2.605e-11 0.29
HS90A_HUMAN HSP90AA1 Heat shock protein HSP 90-alpha 2.956e-11 0.32
GP119_HUMAN GPR119 Glucose-dependent insulinotropic receptor 2.982e-11 0.35
BMR1A_HUMAN BMPR1A Bone morphogenetic protein receptor type-1A 3.181e-11 0.34
GYRB_MYCSM gyrB DNA gyrase subunit B 3.327e-11 0.30
STK3_HUMAN STK3 Serine/threonine-protein kinase 3 3.581e-11 0.37
STK26_HUMAN STK26 Serine/threonine-protein kinase 26 3.595e-11 0.29
BMR1B_HUMAN BMPR1B Bone morphogenetic protein receptor type-1B 4.628e-11 0.34
MK12_HUMAN MAPK12 Mitogen-activated protein kinase 12 5.922e-11 0.34
INSRR_HUMAN INSRR Insulin receptor-related protein 6.132e-11 0.29
M3K4_HUMAN MAP3K4 Mitogen-activated protein kinase kinase kinase 4 6.132e-11 0.29
MAK_HUMAN MAK Serine/threonine-protein kinase MAK 6.446e-11 0.35
KPCD2_HUMAN PRKD2 Serine/threonine-protein kinase D2 7.134e-11 0.35
KPCT_HUMAN PRKCQ Protein kinase C theta type 7.406e-11 0.40
LYN_HUMAN LYN Tyrosine-protein kinase Lyn 9.367e-11 0.43
MINK1_HUMAN MINK1 Misshapen-like kinase 1 1.192e-10 0.37
LATS2_HUMAN LATS2 Serine/threonine-protein kinase LATS2 1.345e-10 0.29
CDK5_HUMAN CDK5 Cyclin-dependent-like kinase 5 1.55e-10 0.40
TXK_HUMAN TXK Tyrosine-protein kinase TXK 1.644e-10 0.30
FRK_HUMAN FRK Tyrosine-protein kinase FRK 2.273e-10 0.35
M3K13_HUMAN MAP3K13 Mitogen-activated protein kinase kinase kinase 13 2.772e-10 0.29
PLK4_HUMAN PLK4 Serine/threonine-protein kinase PLK4 3.665e-10 0.35
MELK_HUMAN MELK Maternal embryonic leucine zipper kinase 3.798e-10 0.37
AURKC_HUMAN AURKC Aurora kinase C 4.11e-10 0.30
PTK6_HUMAN PTK6 Protein-tyrosine kinase 6 4.759e-10 0.34
HIPK1_HUMAN HIPK1 Homeodomain-interacting protein kinase 1 4.885e-10 0.29
ANKK1_HUMAN ANKK1 Ankyrin repeat and protein kinase domain-containing protein 1 5.412e-10 0.29
PI51A_HUMAN PIP5K1A Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha 5.412e-10 0.29
M3K20_HUMAN MAP3K20 Mitogen-activated protein kinase kinase kinase 20 5.462e-10 0.35
IRAK1_HUMAN IRAK1 Interleukin-1 receptor-associated kinase 1 5.918e-10 0.35
NEK11_HUMAN NEK11 Serine/threonine-protein kinase Nek11 7.541e-10 0.29
O97467_PLAFA ht1 Hexose transporter 1 9.219e-10 0.48
SRPK1_HUMAN SRPK1 SRSF protein kinase 1 9.976e-10 0.34
MUSK_HUMAN MUSK Muscle, skeletal receptor tyrosine-protein kinase 1.007e-09 0.29
STK25_HUMAN STK25 Serine/threonine-protein kinase 25 1.007e-09 0.29
SIK2_HUMAN SIK2 Serine/threonine-protein kinase SIK2 1.116e-09 0.31
CHK2_HUMAN CHEK2 Serine/threonine-protein kinase Chk2 1.172e-09 0.35
M3K10_HUMAN MAP3K10 Mitogen-activated protein kinase kinase kinase 10 1.51e-09 0.31
KIT_HUMAN KIT Mast/stem cell growth factor receptor Kit 1.788e-09 0.41
KKCC1_HUMAN CAMKK1 Calcium/calmodulin-dependent protein kinase kinase 1 1.795e-09 0.29
RIOK3_HUMAN RIOK3 Serine/threonine-protein kinase RIO3 1.795e-09 0.29
STK36_HUMAN STK36 Serine/threonine-protein kinase 36 1.795e-09 0.29
ULK3_HUMAN ULK3 Serine/threonine-protein kinase ULK3 1.795e-09 0.29
STK10_HUMAN STK10 Serine/threonine-protein kinase 10 2.334e-09 0.35
BMPR2_HUMAN BMPR2 Bone morphogenetic protein receptor type-2 3.081e-09 0.29
SRPK3_HUMAN SRPK3 SRSF protein kinase 3 3.081e-09 0.29
PGFRB_HUMAN PDGFRB Platelet-derived growth factor receptor beta 3.639e-09 0.39
NTRK3_HUMAN NTRK3 NT-3 growth factor receptor 4.654e-09 0.40
M3K15_HUMAN MAP3K15 Mitogen-activated protein kinase kinase kinase 15 4.864e-09 0.28
GRK4_HUMAN GRK4 G protein-coupled receptor kinase 4 5.109e-09 0.29
LSS_RAT Lss Lanosterol synthase 5.885e-09 0.30
PAK3_HUMAN PAK3 Serine/threonine-protein kinase PAK 3 6.143e-09 0.32
Q9WKE8_9HIV1 reverse transcriptase Reverse transcriptase 6.997e-09 0.39
IRAK3_HUMAN IRAK3 Interleukin-1 receptor-associated kinase 3 8.216e-09 0.29
VGFR1_HUMAN FLT1 Vascular endothelial growth factor receptor 1 8.487e-09 0.40
CDK19_HUMAN CDK19 Cyclin-dependent kinase 19 8.719e-09 0.40
DYR1A_HUMAN DYRK1A Dual specificity tyrosine-phosphorylation-regulated kinase 1A 9.306e-09 0.40
CD11A_HUMAN CDK11A Cyclin-dependent kinase 11A 9.993e-09 0.35
CDK13_HUMAN CDK13 Cyclin-dependent kinase 13 9.993e-09 0.35
O61059_LEIME LmGT2 Glucose transporter 1.045e-08 0.48
EPHA7_HUMAN EPHA7 Ephrin type-A receptor 7 1.285e-08 0.29
MP2K3_HUMAN MAP2K3 Dual specificity mitogen-activated protein kinase kinase 3 1.285e-08 0.29
PHKG1_HUMAN PHKG1 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 1.285e-08 0.29
TNK1_HUMAN TNK1 Non-receptor tyrosine-protein kinase TNK1 1.285e-08 0.29
MK06_HUMAN MAPK6 Mitogen-activated protein kinase 6 1.322e-08 0.29
AVR2A_HUMAN ACVR2A Activin receptor type-2A 1.751e-08 0.28
KAPCB_HUMAN PRKACB cAMP-dependent protein kinase catalytic subunit beta 1.751e-08 0.28
ST32B_HUMAN STK32B Serine/threonine-protein kinase 32B 1.751e-08 0.28
ST38L_HUMAN STK38L Serine/threonine-protein kinase 38-like 1.751e-08 0.28
MARK2_HUMAN MARK2 Serine/threonine-protein kinase MARK2 1.865e-08 0.35
GRK7_HUMAN GRK7 Rhodopsin kinase GRK7 1.958e-08 0.29
M3K3_HUMAN MAP3K3 Mitogen-activated protein kinase kinase kinase 3 1.958e-08 0.29
MP2K4_HUMAN MAP2K4 Dual specificity mitogen-activated protein kinase kinase 4 1.958e-08 0.29
KPCG_HUMAN PRKCG Protein kinase C gamma type 1.978e-08 0.35
BMX_HUMAN BMX Cytoplasmic tyrosine-protein kinase BMX 2.828e-08 0.29
LIMK1_HUMAN LIMK1 LIM domain kinase 1 2.856e-08 0.38
GTR1_HUMAN SLC2A1 Solute carrier family 2, facilitated glucose transporter member 1 3.305e-08 0.48
KGP1_HUMAN PRKG1 cGMP-dependent protein kinase 1 3.355e-08 0.35
SGK2_HUMAN SGK2 Serine/threonine-protein kinase Sgk2 3.628e-08 0.35
TLK2_HUMAN TLK2 Serine/threonine-protein kinase tousled-like 2 3.985e-08 0.29
MRCKA_HUMAN CDC42BPA Serine/threonine-protein kinase MRCK alpha 4.086e-08 0.35
BMP2K_HUMAN BMP2K BMP-2-inducible protein kinase 4.255e-08 0.29
DAPK2_HUMAN DAPK2 Death-associated protein kinase 2 4.255e-08 0.29
SIK1_HUMAN SIK1 Serine/threonine-protein kinase SIK1 4.255e-08 0.29
ABL1_HUMAN ABL1 Tyrosine-protein kinase ABL1 4.546e-08 0.42
STK16_HUMAN STK16 Serine/threonine-protein kinase 16 6.087e-08 0.29
HCK_HUMAN HCK Tyrosine-protein kinase HCK 6.98e-08 0.31
TGM1_HUMAN TGM1 Protein-glutamine gamma-glutamyltransferase K 7.16e-08 0.30
KC1G2_HUMAN CSNK1G2 Casein kinase I isoform gamma-2 7.73e-08 0.35
REV1_HUMAN REV1 DNA repair protein REV1 8.352e-08 0.29
DAPK1_HUMAN DAPK1 Death-associated protein kinase 1 8.554e-08 0.29
EPHA4_HUMAN EPHA4 Ephrin type-A receptor 4 8.554e-08 0.29
M4K3_HUMAN MAP4K3 Mitogen-activated protein kinase kinase kinase kinase 3 8.554e-08 0.29
NUAK2_HUMAN NUAK2 NUAK family SNF1-like kinase 2 8.554e-08 0.29
CD11B_HUMAN CDK11B Cyclin-dependent kinase 11B 1.064e-07 0.35
HIPK3_HUMAN HIPK3 Homeodomain-interacting protein kinase 3 1.183e-07 0.29
M3K2_HUMAN MAP3K2 Mitogen-activated protein kinase kinase kinase 2 1.183e-07 0.29
SYK_HUMAN KARS1 Lysine--tRNA ligase 1.244e-07 0.37
FGR_HUMAN FGR Tyrosine-protein kinase Fgr 1.288e-07 0.37
KCC4_HUMAN CAMK4 Calcium/calmodulin-dependent protein kinase type IV 1.324e-07 0.28
MAST1_HUMAN MAST1 Microtubule-associated serine/threonine-protein kinase 1 1.324e-07 0.28
MYO3A_HUMAN MYO3A Myosin-IIIa 1.324e-07 0.28
OXSR1_HUMAN OXSR1 Serine/threonine-protein kinase OSR1 1.324e-07 0.28
M4K1_HUMAN MAP4K1 Mitogen-activated protein kinase kinase kinase kinase 1 1.61e-07 0.29
EPHA1_HUMAN EPHA1 Ephrin type-A receptor 1 2.162e-07 0.29
EPHB1_HUMAN EPHB1 Ephrin type-B receptor 1 2.162e-07 0.29
TEC_HUMAN TEC Tyrosine-protein kinase Tec 2.268e-07 0.28
ACV1B_HUMAN ACVR1B Activin receptor type-1B 2.865e-07 0.29
EPHA6_HUMAN EPHA6 Ephrin type-A receptor 6 2.865e-07 0.29
BRDT_HUMAN BRDT Bromodomain testis-specific protein 2.99e-07 0.38
KC1AL_HUMAN CSNK1A1L Casein kinase I isoform alpha-like 2.994e-07 0.28
MRCKB_HUMAN CDC42BPB Serine/threonine-protein kinase MRCK beta 2.994e-07 0.28
MRCKG_HUMAN CDC42BPG Serine/threonine-protein kinase MRCK gamma 2.994e-07 0.28
MYO3B_HUMAN MYO3B Myosin-IIIb 2.994e-07 0.28
ST32A_HUMAN STK32A Serine/threonine-protein kinase 32A 2.994e-07 0.28
E2AK2_HUMAN EIF2AK2 Interferon-induced, double-stranded RNA-activated protein kinase 3.292e-07 0.29
PDPK1_HUMAN PDPK1 3-phosphoinositide-dependent protein kinase 1 3.717e-07 0.35
EPHB2_HUMAN EPHB2 Ephrin type-B receptor 2 3.75e-07 0.29
CDC7_HUMAN CDC7 Cell division cycle 7-related protein kinase 3.824e-07 0.37
NEK5_HUMAN NEK5 Serine/threonine-protein kinase Nek5 4.905e-07 0.29
SRPK2_HUMAN SRPK2 SRSF protein kinase 2 4.905e-07 0.29
STK11_HUMAN STK11 Serine/threonine-protein kinase STK11 4.905e-07 0.29
TLK1_HUMAN TLK1 Serine/threonine-protein kinase tousled-like 1 4.905e-07 0.29
ADA2C_HUMAN ADRA2C Alpha-2C adrenergic receptor 4.931e-07 0.34
JUN_HUMAN JUN Transcription factor AP-1 4.931e-07 0.30
TNIK_HUMAN TNIK TRAF2 and NCK-interacting protein kinase 4.977e-07 0.29
TIE1_HUMAN TIE1 Tyrosine-protein kinase receptor Tie-1 6.218e-07 0.29
5HT3A_CAVPO HTR3A 5-hydroxytryptamine receptor 3A 6.689e-07 0.28
ITK_HUMAN ITK Tyrosine-protein kinase ITK/TSK 6.76e-07 0.35
FGFR1_HUMAN FGFR1 Fibroblast growth factor receptor 1 7.512e-07 0.42
KC1G1_HUMAN CSNK1G1 Casein kinase I isoform gamma-1 8.511e-07 0.35
C11B2_RAT Cyp11b2 Cytochrome P450 11B2, mitochondrial 1.03e-06 0.30
HYES_MOUSE Ephx2 Bifunctional epoxide hydrolase 2 1.136e-06 0.33
HUNK_HUMAN HUNK Hormonally up-regulated neu tumor-associated kinase 1.166e-06 0.28
AAK1_HUMAN AAK1 AP2-associated protein kinase 1 1.235e-06 0.29
EPHB6_HUMAN EPHB6 Ephrin type-B receptor 6 1.235e-06 0.29
EPHA2_HUMAN EPHA2 Ephrin type-A receptor 2 1.451e-06 0.34
MAT1_HUMAN MNAT1 CDK-activating kinase assembly factor MAT1 1.653e-06 0.31
SGK3_HUMAN SGK3 Serine/threonine-protein kinase Sgk3 1.683e-06 0.29
LGUL_HUMAN GLO1 Lactoylglutathione lyase 1.698e-06 0.30
KS6B1_HUMAN RPS6KB1 Ribosomal protein S6 kinase beta-1 1.804e-06 0.35
YES_HUMAN YES1 Tyrosine-protein kinase Yes 1.832e-06 0.37
LATS1_HUMAN LATS1 Serine/threonine-protein kinase LATS1 2.07e-06 0.28
MK01_HUMAN MAPK1 Mitogen-activated protein kinase 1 2.924e-06 0.39
MKNK2_HUMAN MKNK2 MAP kinase-interacting serine/threonine-protein kinase 2 3.264e-06 0.37
MP2K5_HUMAN MAP2K5 Dual specificity mitogen-activated protein kinase kinase 5 3.308e-06 0.29
ROCK1_HUMAN ROCK1 Rho-associated protein kinase 1 3.347e-06 0.40
AVR2B_HUMAN ACVR2B Activin receptor type-2B 3.477e-06 0.28
STK24_HUMAN STK24 Serine/threonine-protein kinase 24 3.477e-06 0.28
KS6A4_HUMAN RPS6KA4 Ribosomal protein S6 kinase alpha-4 3.95e-06 0.29
MK14_HUMAN MAPK14 Mitogen-activated protein kinase 14 4.208e-06 0.37
F13A_HUMAN F13A1 Coagulation factor XIII A chain 4.399e-06 0.30
DPOL_VACCW POL DNA polymerase 4.865e-06 0.29
NEMO_HUMAN IKBKG NF-kappa-B essential modulator 5.155e-06 0.29
E2AK4_HUMAN EIF2AK4 eIF-2-alpha kinase GCN2 5.537e-06 0.29
EPHA3_HUMAN EPHA3 Ephrin type-A receptor 3 5.537e-06 0.29
ABL2_HUMAN ABL2 Tyrosine-protein kinase ABL2 6.503e-06 0.29
MYLK3_HUMAN MYLK3 Myosin light chain kinase 3 7.112e-06 0.29
MYLK4_HUMAN MYLK4 Myosin light chain kinase family member 4 7.112e-06 0.29
KC1D_HUMAN CSNK1D Casein kinase I isoform delta 7.328e-06 0.37
ADA2A_HUMAN ADRA2A Alpha-2A adrenergic receptor 7.629e-06 0.34
TAOK3_HUMAN TAOK3 Serine/threonine-protein kinase TAO3 7.796e-06 0.35
KS6A1_HUMAN RPS6KA1 Ribosomal protein S6 kinase alpha-1 8.387e-06 0.29
MAPK2_HUMAN MAPKAPK2 MAP kinase-activated protein kinase 2 8.404e-06 0.34

Apitolisib

PK3CA_HUMAN PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 9.645e-69 1.00
MTOR_HUMAN MTOR Serine/threonine-protein kinase mTOR 5.036e-58 1.00
P3C2A_HUMAN PIK3C2A Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha 4.405e-39 1.00
PK3CD_HUMAN PIK3CD Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 2.685e-37 1.00
PK3CG_HUMAN PIK3CG Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 2.298e-32 1.00
P3C2B_HUMAN PIK3C2B Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta 5.586e-28 1.00
PK3CB_HUMAN PIK3CB Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 5.047e-25 1.00
PK3C3_HUMAN PIK3C3 Phosphatidylinositol 3-kinase catalytic subunit type 3 1.182e-12 1.00
M3K9_HUMAN MAP3K9 Mitogen-activated protein kinase kinase kinase 9 5.944e-12 1.00
FGR_HUMAN FGR Tyrosine-protein kinase Fgr 4.014e-08 1.00
PRKDC_HUMAN PRKDC DNA-dependent protein kinase catalytic subunit 0.02186 1.00
KSYK_HUMAN SYK Tyrosine-protein kinase SYK 0.8615 1.00
P85A_HUMAN PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha 1.958e-59 0.56
PI3R5_HUMAN PIK3R5 Phosphoinositide 3-kinase regulatory subunit 5 5.891e-34 0.35
P3C2G_HUMAN PIK3C2G Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma 1.559e-13 0.35
RIOK2_HUMAN RIOK2 Serine/threonine-protein kinase RIO2 6.382e-11 0.35
NCOR2_HUMAN NCOR2 Nuclear receptor corepressor 2 1.39e-10 0.40
TBK1_HUMAN TBK1 Serine/threonine-protein kinase TBK1 3.924e-09 0.35
DAPK1_HUMAN DAPK1 Death-associated protein kinase 1 5.692e-09 0.35
HIPK3_HUMAN HIPK3 Homeodomain-interacting protein kinase 3 8.292e-09 0.35
HIPK1_HUMAN HIPK1 Homeodomain-interacting protein kinase 1 5.7e-08 0.35
IKKE_HUMAN IKBKE Inhibitor of nuclear factor kappa-B kinase subunit epsilon 6.195e-08 0.35
CDK18_HUMAN CDK18 Cyclin-dependent kinase 18 1.307e-07 0.35
KCC1G_HUMAN CAMK1G Calcium/calmodulin-dependent protein kinase type 1G 1.307e-07 0.35
HDA10_HUMAN HDAC10 Polyamine deacetylase HDAC10 1.521e-07 0.40
CILK1_HUMAN CILK1 Serine/threonine-protein kinase ICK 4.049e-07 0.35
MYLK4_HUMAN MYLK4 Myosin light chain kinase family member 4 4.049e-07 0.35
PK3CA_BOVIN PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 4.542e-07 0.31
HDAC5_HUMAN HDAC5 Histone deacetylase 5 2.271e-06 0.40
M3K19_HUMAN MAP3K19 Mitogen-activated protein kinase kinase kinase 19 2.381e-06 0.35
HDAC7_HUMAN HDAC7 Histone deacetylase 7 2.894e-06 0.40
IRAK3_HUMAN IRAK3 Interleukin-1 receptor-associated kinase 3 8.923e-06 0.35
HDAC1_HUMAN HDAC1 Histone deacetylase 1 9.535e-06 0.42

Baricitinib

JAK1_HUMAN JAK1 Tyrosine-protein kinase JAK1 2.243e-67 1.00
JAK3_HUMAN JAK3 Tyrosine-protein kinase JAK3 2.901e-63 1.00
JAK2_HUMAN JAK2 Tyrosine-protein kinase JAK2 4.935e-54 1.00
TYK2_HUMAN TYK2 Non-receptor tyrosine-protein kinase TYK2 1.013e-48 1.00
JAK3_RAT Jak3 Tyrosine-protein kinase JAK3 1.551e-39 0.31
VRK2_HUMAN VRK2 Serine/threonine-protein kinase VRK2 9.45e-22 0.49
TNI3K_HUMAN TNNI3K Serine/threonine-protein kinase TNNI3K 5.794e-18 0.31
NEK3_HUMAN NEK3 Serine/threonine-protein kinase Nek3 1.338e-17 0.49
M3K15_HUMAN MAP3K15 Mitogen-activated protein kinase kinase kinase 15 4.885e-15 0.49
ULK3_HUMAN ULK3 Serine/threonine-protein kinase ULK3 4.657e-13 0.49
SYTC_HUMAN TARS1 Threonine--tRNA ligase 1, cytoplasmic 7.13e-13 0.35
SYT_YERPE thrS Threonine--tRNA ligase 7.13e-13 0.35
JAK2_MOUSE Jak2 Tyrosine-protein kinase JAK2 8.579e-13 0.31
DMPK_HUMAN DMPK Myotonin-protein kinase 9.933e-13 0.49
CSKP_HUMAN CASK Peripheral plasma membrane protein CASK 1.413e-12 0.49
MAST1_HUMAN MAST1 Microtubule-associated serine/threonine-protein kinase 1 1.413e-12 0.49
OXSR1_HUMAN OXSR1 Serine/threonine-protein kinase OSR1 1.413e-12 0.49
STK39_HUMAN STK39 STE20/SPS1-related proline-alanine-rich protein kinase 1.413e-12 0.49
DCLK3_HUMAN DCLK3 Serine/threonine-protein kinase DCLK3 3.929e-12 0.49
DCLK2_HUMAN DCLK2 Serine/threonine-protein kinase DCLK2 5.729e-12 0.49
GRK7_HUMAN GRK7 Rhodopsin kinase GRK7 1.328e-11 0.49
NEK7_HUMAN NEK7 Serine/threonine-protein kinase Nek7 1.967e-11 0.49
SBK3_HUMAN SBK3 Uncharacterized serine/threonine-protein kinase SBK3 1.967e-11 0.49
SIK3_HUMAN SIK3 Serine/threonine-protein kinase SIK3 1.967e-11 0.49
TPX2_HUMAN TPX2 Targeting protein for Xklp2 2.335e-11 0.33
BMP2K_HUMAN BMP2K BMP-2-inducible protein kinase 3.938e-11 0.49
KS6A6_HUMAN RPS6KA6 Ribosomal protein S6 kinase alpha-6 3.938e-11 0.49
M3K1_HUMAN MAP3K1 Mitogen-activated protein kinase kinase kinase 1 5.887e-11 0.49
JAK3_MOUSE Jak3 Tyrosine-protein kinase JAK3 1.011e-10 0.31
NUAK2_HUMAN NUAK2 NUAK family SNF1-like kinase 2 1.047e-10 0.49
KCC1D_HUMAN CAMK1D Calcium/calmodulin-dependent protein kinase type 1D 1.052e-10 0.49
KCC1G_HUMAN CAMK1G Calcium/calmodulin-dependent protein kinase type 1G 3.818e-10 0.49
SBK1_HUMAN SBK1 Serine/threonine-protein kinase SBK1 3.818e-10 0.49
PAK6_HUMAN PAK6 Serine/threonine-protein kinase PAK 6 8.54e-10 0.49
RIPK4_HUMAN RIPK4 Receptor-interacting serine/threonine-protein kinase 4 8.54e-10 0.49
ANKK1_HUMAN ANKK1 Ankyrin repeat and protein kinase domain-containing protein 1 1.155e-08 0.49
PAK5_HUMAN PAK5 Serine/threonine-protein kinase PAK 5 1.155e-08 0.49
STK25_HUMAN STK25 Serine/threonine-protein kinase 25 1.969e-08 0.49
RIOK1_HUMAN RIOK1 Serine/threonine-protein kinase RIO1 3.236e-08 0.49
RIOK2_HUMAN RIOK2 Serine/threonine-protein kinase RIO2 3.236e-08 0.49
RIOK3_HUMAN RIOK3 Serine/threonine-protein kinase RIO3 3.236e-08 0.49
KCC2A_HUMAN CAMK2A Calcium/calmodulin-dependent protein kinase type II subunit alpha 4.149e-08 0.49
BMPR2_HUMAN BMPR2 Bone morphogenetic protein receptor type-2 5.146e-08 0.49
SRPK3_HUMAN SRPK3 SRSF protein kinase 3 5.146e-08 0.49
GRK1_HUMAN GRK1 Rhodopsin kinase GRK1 7.948e-08 0.49
GRK4_HUMAN GRK4 G protein-coupled receptor kinase 4 7.948e-08 0.49
ULK1_HUMAN ULK1 Serine/threonine-protein kinase ULK1 1.195e-07 0.49
MP2K3_HUMAN MAP2K3 Dual specificity mitogen-activated protein kinase kinase 3 1.755e-07 0.49
PHKG1_HUMAN PHKG1 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 1.755e-07 0.49
ULK2_HUMAN ULK2 Serine/threonine-protein kinase ULK2 1.755e-07 0.49
M3K3_HUMAN MAP3K3 Mitogen-activated protein kinase kinase kinase 3 2.522e-07 0.49
MP2K4_HUMAN MAP2K4 Dual specificity mitogen-activated protein kinase kinase 4 2.522e-07 0.49
DAPK2_HUMAN DAPK2 Death-associated protein kinase 2 4.913e-07 0.49
TAOK2_HUMAN TAOK2 Serine/threonine-protein kinase TAO2 4.913e-07 0.49
STK16_HUMAN STK16 Serine/threonine-protein kinase 16 6.684e-07 0.49
DAPK1_HUMAN DAPK1 Death-associated protein kinase 1 8.955e-07 0.49
DCLK1_HUMAN DCLK1 Serine/threonine-protein kinase DCLK1 1.008e-06 0.49
PKNB_MYCTU pknB Serine/threonine-protein kinase PknB 1.008e-06 0.49
HIPK3_HUMAN HIPK3 Homeodomain-interacting protein kinase 3 1.183e-06 0.49
M3K2_HUMAN MAP3K2 Mitogen-activated protein kinase kinase kinase 2 1.183e-06 0.49
STK26_HUMAN STK26 Serine/threonine-protein kinase 26 1.183e-06 0.49
BMR1B_HUMAN BMPR1B Bone morphogenetic protein receptor type-1B 3.192e-06 0.49
MP2K2_HUMAN MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 4.104e-06 0.49
HIPK1_HUMAN HIPK1 Homeodomain-interacting protein kinase 1 4.932e-06 0.49
GRK5_HUMAN GRK5 G protein-coupled receptor kinase 5 7.656e-06 0.49
AAK1_HUMAN AAK1 AP2-associated protein kinase 1 8.9e-06 0.49
EPHB6_HUMAN EPHB6 Ephrin type-B receptor 6 8.9e-06 0.49

PD173074

FGFR1_HUMAN FGFR1 Fibroblast growth factor receptor 1 7.736e-53 1.00
VGFR2_HUMAN KDR Vascular endothelial growth factor receptor 2 2.962e-07 1.00
FGFR2_HUMAN FGFR2 Fibroblast growth factor receptor 2 0.0001977 1.00
FGFR3_HUMAN FGFR3 Fibroblast growth factor receptor 3 0.008368 1.00
SRC_CHICK SRC Proto-oncogene tyrosine-protein kinase Src 2.077e-113 0.75
PGFRB_MOUSE Pdgfrb Platelet-derived growth factor receptor beta 4.603e-80 0.75
RASK_HUMAN KRAS GTPase KRas 2.331e-15 0.33
PI3R5_HUMAN PIK3R5 Phosphoinositide 3-kinase regulatory subunit 5 2.04e-11 0.31
SRC_HUMAN SRC Proto-oncogene tyrosine-protein kinase Src 2.751e-08 0.70
SRC_MOUSE Src Neuronal proto-oncogene tyrosine-protein kinase Src 5.848e-08 0.29
M3K1_HUMAN MAP3K1 Mitogen-activated protein kinase kinase kinase 1 1.636e-07 0.32
LSHR_HUMAN LHCGR Lutropin-choriogonadotropic hormone receptor 5.652e-06 0.28

BX795

CGAS_HUMAN CGAS Cyclic GMP-AMP synthase 1.089e-50 1.00
ULK1_HUMAN ULK1 Serine/threonine-protein kinase ULK1 3.441e-46 1.00
ULK2_HUMAN ULK2 Serine/threonine-protein kinase ULK2 4.063e-45 1.00
PDK1_HUMAN PDK1 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial 8.404e-06 1.00
TBK1_MOUSE Tbk1 Serine/threonine-protein kinase TBK1 2.165e-130 0.42
TBK1_HUMAN TBK1 Serine/threonine-protein kinase TBK1 3.847e-32 0.84
KISSR_HUMAN KISS1R KiSS-1 receptor 6.129e-29 0.32
SRC_CHICK SRC Proto-oncogene tyrosine-protein kinase Src 3.812e-26 0.33
TYRO3_HUMAN TYRO3 Tyrosine-protein kinase receptor TYRO3 4.608e-24 0.35
STAT6_HUMAN STAT6 Signal transducer and activator of transcription 6 1.972e-23 0.31
BMX_HUMAN BMX Cytoplasmic tyrosine-protein kinase BMX 5.979e-20 0.34
PGFRB_MOUSE Pdgfrb Platelet-derived growth factor receptor beta 1.451e-18 0.33
BCR_HUMAN BCR Breakpoint cluster region protein 2.139e-18 0.29
CCND3_HUMAN CCND3 G1/S-specific cyclin-D3 7.809e-18 0.35
BRSK2_HUMAN BRSK2 Serine/threonine-protein kinase BRSK2 4.53e-14 0.36
SNRK_HUMAN SNRK SNF-related serine/threonine-protein kinase 1.052e-13 0.30
BTK_HUMAN BTK Tyrosine-protein kinase BTK 1.743e-13 0.34
WEE2_HUMAN WEE2 Wee1-like protein kinase 2 2.579e-13 0.30
NAMPT_HUMAN NAMPT Nicotinamide phosphoribosyltransferase 1.55e-12 0.35
JAK3_HUMAN JAK3 Tyrosine-protein kinase JAK3 1.633e-12 0.35
Q8MI13_BOVIN 5htr1d 5-hydroxytryptamine 1D receptor 2.95e-12 0.29
DUS22_HUMAN DUSP22 Dual specificity protein phosphatase 22 4.484e-12 0.32
MATK_HUMAN MATK Megakaryocyte-associated tyrosine-protein kinase 1.145e-11 0.30
NEMO_HUMAN IKBKG NF-kappa-B essential modulator 1.149e-11 0.32
NOS1_HUMAN NOS1 Nitric oxide synthase, brain 1.305e-11 0.32
FAAH1_HUMAN FAAH Fatty-acid amide hydrolase 1 1.967e-11 0.33
PDPK1_HUMAN PDPK1 3-phosphoinositide-dependent protein kinase 1 3.265e-11 0.84
ALK_HUMAN ALK ALK tyrosine kinase receptor 3.801e-11 0.45
NEK3_HUMAN NEK3 Serine/threonine-protein kinase Nek3 3.845e-11 0.30
MET_HUMAN MET Hepatocyte growth factor receptor 1.66e-10 0.45
NEK11_HUMAN NEK11 Serine/threonine-protein kinase Nek11 2.867e-10 0.30
ITB2_HUMAN ITGB2 Integrin beta-2 3.031e-10 0.30
CDN1A_HUMAN CDKN1A Cyclin-dependent kinase inhibitor 1 3.253e-10 0.34
ANM3_HUMAN PRMT3 Protein arginine N-methyltransferase 3 4.335e-10 0.29
TSSK1_HUMAN TSSK1B Testis-specific serine/threonine-protein kinase 1 4.811e-10 0.30
INSR_HUMAN INSR Insulin receptor 7.762e-10 0.33
SRMS_HUMAN SRMS Tyrosine-protein kinase Srms 1.033e-09 0.30
STK38_HUMAN STK38 Serine/threonine-protein kinase 38 1.469e-09 0.30
BLK_HUMAN BLK Tyrosine-protein kinase Blk 3.719e-09 0.30
MK06_HUMAN MAPK6 Mitogen-activated protein kinase 6 5.728e-09 0.30
CSN5_HUMAN COPS5 COP9 signalosome complex subunit 5 9.651e-09 0.29
NOS3_HUMAN NOS3 Nitric oxide synthase, endothelial 9.761e-09 0.31
ITAL_HUMAN ITGAL Integrin alpha-L 1.035e-08 0.30
ABL1_HUMAN ABL1 Tyrosine-protein kinase ABL1 1.112e-08 0.43
KSYK_HUMAN SYK Tyrosine-protein kinase SYK 1.133e-08 0.34
EGFR_HUMAN EGFR Epidermal growth factor receptor 1.267e-08 0.34
NEK9_HUMAN NEK9 Serine/threonine-protein kinase Nek9 1.817e-08 0.30
TLK2_HUMAN TLK2 Serine/threonine-protein kinase tousled-like 2 1.817e-08 0.30
TXK_HUMAN TXK Tyrosine-protein kinase TXK 3.819e-08 0.30
KCNK9_HUMAN KCNK9 Potassium channel subfamily K member 9 3.845e-08 0.35
TEC_HUMAN TEC Tyrosine-protein kinase Tec 4.187e-08 0.34
CDKL5_HUMAN CDKL5 Cyclin-dependent kinase-like 5 4.908e-08 0.30
COQ8A_HUMAN COQ8A Atypical kinase COQ8A, mitochondrial 4.908e-08 0.30
CSKP_HUMAN CASK Peripheral plasma membrane protein CASK 4.908e-08 0.30
STK39_HUMAN STK39 STE20/SPS1-related proline-alanine-rich protein kinase 4.908e-08 0.30
DCLK2_HUMAN DCLK2 Serine/threonine-protein kinase DCLK2 1.168e-07 0.30
TIM23_YEAST TIM23 Mitochondrial import inner membrane translocase subunit TIM23 1.374e-07 0.36
DRD1_PIG DRD1 D(1A) dopamine receptor 1.835e-07 0.32
MERTK_HUMAN MERTK Tyrosine-protein kinase Mer 1.913e-07 0.34
COQ8B_HUMAN COQ8B Atypical kinase COQ8B, mitochondrial 2.507e-07 0.30
NEK5_HUMAN NEK5 Serine/threonine-protein kinase Nek5 2.507e-07 0.30
NEK7_HUMAN NEK7 Serine/threonine-protein kinase Nek7 2.507e-07 0.30
SBK3_HUMAN SBK3 Uncharacterized serine/threonine-protein kinase SBK3 2.507e-07 0.30
SIK3_HUMAN SIK3 Serine/threonine-protein kinase SIK3 2.507e-07 0.30
SRPK2_HUMAN SRPK2 SRSF protein kinase 2 2.507e-07 0.30
STK11_HUMAN STK11 Serine/threonine-protein kinase STK11 2.507e-07 0.30
TLK1_HUMAN TLK1 Serine/threonine-protein kinase tousled-like 1 2.507e-07 0.30
ACK1_HUMAN TNK2 Activated CDC42 kinase 1 3.826e-07 0.34
NIM1_HUMAN NIM1K Serine/threonine-protein kinase NIM1 4.948e-07 0.30
PRP4B_HUMAN PRPF4B Serine/threonine-protein kinase PRP4 homolog 4.948e-07 0.30
PYGL_HUMAN PYGL Glycogen phosphorylase, liver form 5.238e-07 0.34
FGFR1_HUMAN FGFR1 Fibroblast growth factor receptor 1 5.914e-07 0.33
ICAM1_HUMAN ICAM1 Intercellular adhesion molecule 1 7.915e-07 0.30
CDK15_HUMAN CDK15 Cyclin-dependent kinase 15 9.101e-07 0.30
SGK3_HUMAN SGK3 Serine/threonine-protein kinase Sgk3 9.101e-07 0.30
CDK18_HUMAN CDK18 Cyclin-dependent kinase 18 1.578e-06 0.30
KCC1G_HUMAN CAMK1G Calcium/calmodulin-dependent protein kinase type 1G 1.578e-06 0.30
SBK1_HUMAN SBK1 Serine/threonine-protein kinase SBK1 1.578e-06 0.30
KGP2_HUMAN PRKG2 cGMP-dependent protein kinase 2 1.874e-06 0.30
BRDT_HUMAN BRDT Bromodomain testis-specific protein 1.898e-06 0.30
CSK21_HUMAN CSNK2A1 Casein kinase II subunit alpha 2.023e-06 0.32
ERBB4_HUMAN ERBB4 Receptor tyrosine-protein kinase erbB-4 2.283e-06 0.30
NEK6_HUMAN NEK6 Serine/threonine-protein kinase Nek6 2.601e-06 0.30
PAK6_HUMAN PAK6 Serine/threonine-protein kinase PAK 6 2.601e-06 0.30
RIPK4_HUMAN RIPK4 Receptor-interacting serine/threonine-protein kinase 4 2.601e-06 0.30
DPOL_VACCW POL DNA polymerase 2.965e-06 0.31
NOS1_RAT Nos1 Nitric oxide synthase, brain 3.122e-06 0.38
AURKA_HUMAN AURKA Aurora kinase A 3.173e-06 0.51
FES_HUMAN FES Tyrosine-protein kinase Fes/Fps 3.764e-06 0.30
CCNT1_HUMAN CCNT1 Cyclin-T1 3.814e-06 0.35
CILK1_HUMAN CILK1 Serine/threonine-protein kinase ICK 4.105e-06 0.30
INSRR_HUMAN INSRR Insulin receptor-related protein 4.105e-06 0.30
M3K4_HUMAN MAP3K4 Mitogen-activated protein kinase kinase kinase 4 4.105e-06 0.30
MYLK3_HUMAN MYLK3 Myosin light chain kinase 3 4.105e-06 0.30
MYLK4_HUMAN MYLK4 Myosin light chain kinase family member 4 4.105e-06 0.30
M3K20_HUMAN MAP3K20 Mitogen-activated protein kinase kinase kinase 20 5.067e-06 0.30
KLK7_HUMAN KLK7 Kallikrein-7 5.141e-06 0.33
SRC_HUMAN SRC Proto-oncogene tyrosine-protein kinase Src 5.438e-06 0.43
CDK14_HUMAN CDK14 Cyclin-dependent kinase 14 6.241e-06 0.30
DUSTY_HUMAN DSTYK Dual serine/threonine and tyrosine protein kinase 6.241e-06 0.30
LATS2_HUMAN LATS2 Serine/threonine-protein kinase LATS2 6.241e-06 0.30
PI42B_HUMAN PIP4K2B Phosphatidylinositol 5-phosphate 4-kinase type-2 beta 6.241e-06 0.30
TESK1_HUMAN TESK1 Dual specificity testis-specific protein kinase 1 6.241e-06 0.30
SRPK1_HUMAN SRPK1 SRSF protein kinase 1 6.28e-06 0.30
PGFRA_HUMAN PDGFRA Platelet-derived growth factor receptor alpha 6.876e-06 0.32
STABP_HUMAN STAMBP STAM-binding protein 8.695e-06 0.29
CDK17_HUMAN CDK17 Cyclin-dependent kinase 17 9.182e-06 0.30
M3K13_HUMAN MAP3K13 Mitogen-activated protein kinase kinase kinase 13 9.182e-06 0.30

XL019

IKKB_HUMAN IKBKB Inhibitor of nuclear factor kappa-B kinase subunit beta 1.814e-47 1.00
JAK3_HUMAN JAK3 Tyrosine-protein kinase JAK3 2.653e-27 1.00
JAK2_HUMAN JAK2 Tyrosine-protein kinase JAK2 8.109e-26 1.00
PGFRA_HUMAN PDGFRA Platelet-derived growth factor receptor alpha 1.588e-22 1.00
KIT_HUMAN KIT Mast/stem cell growth factor receptor Kit 6.861e-19 1.00
FLT3_HUMAN FLT3 Receptor-type tyrosine-protein kinase FLT3 8.056e-18 1.00
PGFRB_HUMAN PDGFRB Platelet-derived growth factor receptor beta 7.772e-15 1.00
VGFR2_HUMAN KDR Vascular endothelial growth factor receptor 2 1.461e-11 1.00
VGFR1_HUMAN FLT1 Vascular endothelial growth factor receptor 1 5.842e-10 1.00
M3K9_HUMAN MAP3K9 Mitogen-activated protein kinase kinase kinase 9 2.882e-08 1.00
TYK2_HUMAN TYK2 Non-receptor tyrosine-protein kinase TYK2 1.679e-07 1.00
VGFR3_HUMAN FLT4 Vascular endothelial growth factor receptor 3 4.16e-05 1.00
JAK1_HUMAN JAK1 Tyrosine-protein kinase JAK1 0.001383 1.00
KS6B1_HUMAN RPS6KB1 Ribosomal protein S6 kinase beta-1 0.1584 1.00
IKKE_HUMAN IKBKE Inhibitor of nuclear factor kappa-B kinase subunit epsilon 1.272e-174 0.51
TBK1_HUMAN TBK1 Serine/threonine-protein kinase TBK1 2.438e-159 0.51
SMG1_HUMAN SMG1 Serine/threonine-protein kinase SMG1 3.405e-128 0.49
CCND2_HUMAN CCND2 G1/S-specific cyclin-D2 1.754e-127 0.42
F262_HUMAN PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 4.323e-93 0.37
STAT6_HUMAN STAT6 Signal transducer and activator of transcription 6 3.233e-90 0.41
F261_HUMAN PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 1.208e-88 0.37
CCND1_HUMAN CCND1 G1/S-specific cyclin-D1 4.422e-88 0.42
RIPK1_MOUSE Ripk1 Receptor-interacting serine/threonine-protein kinase 1 3.047e-85 0.44
CCND3_HUMAN CCND3 G1/S-specific cyclin-D3 1.239e-81 0.42
NEMO_HUMAN IKBKG NF-kappa-B essential modulator 3.417e-79 0.36
KSYK_HUMAN SYK Tyrosine-protein kinase SYK 7.531e-78 0.46
MTOR_RAT Mtor Serine/threonine-protein kinase mTOR 5.57e-75 0.38
MTOR_HUMAN MTOR Serine/threonine-protein kinase mTOR 5.18e-66 0.42
BCR_HUMAN BCR Breakpoint cluster region protein 9.337e-59 0.38
CDK4_HUMAN CDK4 Cyclin-dependent kinase 4 5.023e-57 0.50
CD63_HUMAN CD63 CD63 antigen 5.393e-50 0.36
MK10_HUMAN MAPK10 Mitogen-activated protein kinase 10 3.181e-48 0.49
IKKA_HUMAN CHUK Inhibitor of nuclear factor kappa-B kinase subunit alpha 2.013e-46 0.63
JAK3_MOUSE Jak3 Tyrosine-protein kinase JAK3 3.932e-44 0.38
CCNA2_HUMAN CCNA2 Cyclin-A2 1.642e-43 0.42
INSR_HUMAN INSR Insulin receptor 1.928e-43 0.46
CDK2_HUMAN CDK2 Cyclin-dependent kinase 2 3.483e-41 0.50
IGF1R_HUMAN IGF1R Insulin-like growth factor 1 receptor 5.263e-41 0.49
CCNH_HUMAN CCNH Cyclin-H 1.05e-39 0.34
CCNB1_HUMAN CCNB1 G2/mitotic-specific cyclin-B1 1.94e-38 0.42
PK3CA_HUMAN PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 2.049e-38 0.39
MAPK5_HUMAN MAPKAPK5 MAP kinase-activated protein kinase 5 5.162e-38 0.38
CCNE2_HUMAN CCNE2 G1/S-specific cyclin-E2 1.161e-35 0.42
CDK6_HUMAN CDK6 Cyclin-dependent kinase 6 1.354e-33 0.39
PRIO_SHEEP PRNP Major prion protein 5.671e-31 0.34
PK3CG_HUMAN PIK3CG Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 9.941e-31 0.38
CDK7_HUMAN CDK7 Cyclin-dependent kinase 7 1.469e-29 0.43
ERBB2_HUMAN ERBB2 Receptor tyrosine-protein kinase erbB-2 4.718e-29 0.46
ZAP70_HUMAN ZAP70 Tyrosine-protein kinase ZAP-70 1.652e-28 0.42
CCNB2_HUMAN CCNB2 G2/mitotic-specific cyclin-B2 1.531e-27 0.42
CCNB3_HUMAN CCNB3 G2/mitotic-specific cyclin-B3 1.531e-27 0.42
CDK1_HUMAN CDK1 Cyclin-dependent kinase 1 1.84e-26 0.46
HIPK1_HUMAN HIPK1 Homeodomain-interacting protein kinase 1 9.088e-26 0.36
MP2K1_MOUSE Map2k1 Dual specificity mitogen-activated protein kinase kinase 1 6.482e-25 0.40
MERTK_HUMAN MERTK Tyrosine-protein kinase Mer 1.318e-24 0.36
EPHB4_HUMAN EPHB4 Ephrin type-B receptor 4 1.481e-24 0.39
CCNA1_HUMAN CCNA1 Cyclin-A1 2.849e-24 0.42
MK08_HUMAN MAPK8 Mitogen-activated protein kinase 8 1.699e-23 0.49
FAK1_HUMAN PTK2 Focal adhesion kinase 1 4.896e-23 0.40
JAK2_MOUSE Jak2 Tyrosine-protein kinase JAK2 2.323e-22 0.56
ABL1_HUMAN ABL1 Tyrosine-protein kinase ABL1 6.076e-22 0.46
JUN_HUMAN JUN Transcription factor AP-1 1.88e-21 0.37
F263_HUMAN PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 8.339e-21 0.37
ALK_HUMAN ALK ALK tyrosine kinase receptor 5.921e-20 0.40
ABL1_MOUSE Abl1 Tyrosine-protein kinase ABL1 7.7e-20 0.32
MK09_HUMAN MAPK9 Mitogen-activated protein kinase 9 1.281e-19 0.48
KPCD1_HUMAN PRKD1 Serine/threonine-protein kinase D1 4.402e-19 0.31
HPGDS_HUMAN HPGDS Hematopoietic prostaglandin D synthase 5.779e-19 0.36
TBK1_MOUSE Tbk1 Serine/threonine-protein kinase TBK1 1.189e-18 0.41
MK10_RAT Mapk10 Mitogen-activated protein kinase 10 1.69e-18 0.48
FAK2_HUMAN PTK2B Protein-tyrosine kinase 2-beta 1.741e-18 0.37
PMYT1_HUMAN PKMYT1 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase 2.224e-18 0.39
KCC2D_HUMAN CAMK2D Calcium/calmodulin-dependent protein kinase type II subunit delta 7.358e-18 0.46
M3K7_HUMAN MAP3K7 Mitogen-activated protein kinase kinase kinase 7 1.763e-17 0.37
AURKA_HUMAN AURKA Aurora kinase A 2.022e-17 0.50
TTK_HUMAN TTK Dual specificity protein kinase TTK 4.011e-17 0.40
TYRO3_HUMAN TYRO3 Tyrosine-protein kinase receptor TYRO3 4.242e-17 0.39
P85A_HUMAN PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha 5.009e-17 0.39
BPTF_HUMAN BPTF Nucleosome-remodeling factor subunit BPTF 1.11e-16 0.32
CCNT1_HUMAN CCNT1 Cyclin-T1 1.11e-16 0.43
LCK_HUMAN LCK Tyrosine-protein kinase Lck 1.11e-16 0.46
ACK1_HUMAN TNK2 Activated CDC42 kinase 1 2.22e-16 0.46
EGFR_HUMAN EGFR Epidermal growth factor receptor 4.441e-16 0.46
CCNE1_HUMAN CCNE1 G1/S-specific cyclin-E1 1.554e-15 0.42
CDK9_HUMAN CDK9 Cyclin-dependent kinase 9 1.887e-15 0.46
YES_HUMAN YES1 Tyrosine-protein kinase Yes 4.108e-15 0.41
UFO_HUMAN AXL Tyrosine-protein kinase receptor UFO 1.077e-14 0.42
Q865E1_MACMU HRH3 Histamine receptor H3 4.43e-14 0.33
PK3C3_HUMAN PIK3C3 Phosphatidylinositol 3-kinase catalytic subunit type 3 4.963e-14 0.33
RET_HUMAN RET Proto-oncogene tyrosine-protein kinase receptor Ret 1.145e-13 0.46
KSYK_RAT Syk Tyrosine-protein kinase SYK 2.656e-13 0.36
DKK1_HUMAN DKK1 Dickkopf-related protein 1 3.235e-13 0.32
Q9HUN3_PSEAE dnaB Replicative DNA helicase 4.673e-13 0.28
TAOK1_HUMAN TAOK1 Serine/threonine-protein kinase TAO1 1.025e-12 0.46
LTK_HUMAN LTK Leukocyte tyrosine kinase receptor 1.182e-12 0.46
AURKB_HUMAN AURKB Aurora kinase B 1.852e-12 0.50
KIT_MOUSE Kit Mast/stem cell growth factor receptor Kit 3.001e-12 0.36
MK01_HUMAN MAPK1 Mitogen-activated protein kinase 1 4.202e-12 0.39
WEE1_HUMAN WEE1 Wee1-like protein kinase 5.87e-12 0.46
ROS1_HUMAN ROS1 Proto-oncogene tyrosine-protein kinase ROS 6.844e-12 0.46
HSPB1_HUMAN HSPB1 Heat shock protein beta-1 8.327e-12 0.32
M4K5_HUMAN MAP4K5 Mitogen-activated protein kinase kinase kinase kinase 5 2.231e-11 0.46
MK14_HUMAN MAPK14 Mitogen-activated protein kinase 14 2.56e-11 0.38
FYN_HUMAN FYN Tyrosine-protein kinase Fyn 2.76e-11 0.46
RAF1_HUMAN RAF1 RAF proto-oncogene serine/threonine-protein kinase 3.479e-11 0.33
MP2K1_HUMAN MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 7.897e-11 0.39
O96526_LEIMA CRK3 Cdc2-related kinase 9.604e-11 0.31
CSF1R_HUMAN CSF1R Macrophage colony-stimulating factor 1 receptor 1.176e-10 0.46
BTK_HUMAN BTK Tyrosine-protein kinase BTK 1.232e-10 0.42
KPCD3_HUMAN PRKD3 Serine/threonine-protein kinase D3 2.197e-10 0.46
SRC_HUMAN SRC Proto-oncogene tyrosine-protein kinase Src 2.334e-10 0.46
ISPT_STRPN uppS Isoprenyl transferase 2.691e-10 0.33
NAMPT_HUMAN NAMPT Nicotinamide phosphoribosyltransferase 2.809e-10 0.38
BMR1A_HUMAN BMPR1A Bone morphogenetic protein receptor type-1A 3.186e-10 0.56
AURKC_HUMAN AURKC Aurora kinase C 4.534e-10 0.46
RON_HUMAN MST1R Macrophage-stimulating protein receptor 8.932e-10 0.39
PLK1_HUMAN PLK1 Serine/threonine-protein kinase PLK1 1.055e-09 0.42
S47A2_HUMAN SLC47A2 Multidrug and toxin extrusion protein 2 1.274e-09 0.30
MP2K2_HUMAN MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 1.289e-09 0.39
SYK_HUMAN KARS1 Lysine--tRNA ligase 1.352e-09 0.34
DYR1B_HUMAN DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B 1.42e-09 0.39
M4K2_HUMAN MAP4K2 Mitogen-activated protein kinase kinase kinase kinase 2 1.648e-09 0.46
NEK2_HUMAN NEK2 Serine/threonine-protein kinase Nek2 2.223e-09 0.46
MOT4_HUMAN SLC16A3 Monocarboxylate transporter 4 2.406e-09 0.29
KPCD2_HUMAN PRKD2 Serine/threonine-protein kinase D2 2.543e-09 0.46
FGFR1_HUMAN FGFR1 Fibroblast growth factor receptor 1 3.568e-09 0.46
KLK6_HUMAN KLK6 Kallikrein-6 3.815e-09 0.33
M4K4_HUMAN MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4 4.29e-09 0.46
KC1A_HUMAN CSNK1A1 Casein kinase I isoform alpha 4.395e-09 0.46
STK3_HUMAN STK3 Serine/threonine-protein kinase 3 5.577e-09 0.46
M3K20_HUMAN MAP3K20 Mitogen-activated protein kinase kinase kinase 20 7.257e-09 0.46
LYN_HUMAN LYN Tyrosine-protein kinase Lyn 7.456e-09 0.46
CDK19_HUMAN CDK19 Cyclin-dependent kinase 19 8.715e-09 0.40
ACVR1_HUMAN ACVR1 Activin receptor type-1 1.138e-08 0.56
SRMS_HUMAN SRMS Tyrosine-protein kinase Srms 1.255e-08 0.37
TLR9_HUMAN TLR9 Toll-like receptor 9 1.687e-08 0.32
THRB_BOVIN F2 Prothrombin 1.69e-08 0.30
BRSK2_HUMAN BRSK2 Serine/threonine-protein kinase BRSK2 1.809e-08 0.41
PGH1_SHEEP PTGS1 Prostaglandin G/H synthase 1 1.86e-08 0.39
ERBB4_HUMAN ERBB4 Receptor tyrosine-protein kinase erbB-4 1.992e-08 0.42
PDGFB_HUMAN PDGFB Platelet-derived growth factor subunit B 2e-08 0.46
CLK4_HUMAN CLK4 Dual specificity protein kinase CLK4 2.419e-08 0.46
IRAK4_HUMAN IRAK4 Interleukin-1 receptor-associated kinase 4 2.701e-08 0.46
NK2R_MESAU TACR2 Substance-K receptor 2.822e-08 0.29
BRAF_HUMAN BRAF Serine/threonine-protein kinase B-raf 2.847e-08 0.41
CLK2_HUMAN CLK2 Dual specificity protein kinase CLK2 3.777e-08 0.46
HIPK4_HUMAN HIPK4 Homeodomain-interacting protein kinase 4 4.639e-08 0.46
GSK3B_MOUSE Gsk3b Glycogen synthase kinase-3 beta 4.941e-08 0.30
GSK3B_HUMAN GSK3B Glycogen synthase kinase-3 beta 5.004e-08 0.46
KCC2A_HUMAN CAMK2A Calcium/calmodulin-dependent protein kinase type II subunit alpha 5.011e-08 0.46
DAPK3_HUMAN DAPK3 Death-associated protein kinase 3 6.068e-08 0.46
PAK4_HUMAN PAK4 Serine/threonine-protein kinase PAK 4 7.114e-08 0.46
PDE7A_HUMAN PDE7A High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A 9.661e-08 0.34
GSK3A_HUMAN GSK3A Glycogen synthase kinase-3 alpha 1.113e-07 0.46
KPCA_HUMAN PRKCA Protein kinase C alpha type 1.216e-07 0.32
AAPK1_HUMAN PRKAA1 5'-AMP-activated protein kinase catalytic subunit alpha-1 1.396e-07 0.46
STAT3_MOUSE Stat3 Signal transducer and activator of transcription 3 1.577e-07 0.30
NTRK2_HUMAN NTRK2 BDNF/NT-3 growth factors receptor 1.584e-07 0.39
SCN3A_HUMAN SCN3A Sodium channel protein type 3 subunit alpha 1.609e-07 0.50
MALT1_HUMAN MALT1 Mucosa-associated lymphoid tissue lymphoma translocation protein 1 1.814e-07 0.29
DGAT1_HUMAN DGAT1 Diacylglycerol O-acyltransferase 1 1.952e-07 0.37
SCNAA_MOUSE Scn10a Sodium channel protein type 10 subunit alpha 2.269e-07 0.31
LRRK2_HUMAN LRRK2 Leucine-rich repeat serine/threonine-protein kinase 2 2.475e-07 0.39
PK3CB_HUMAN PIK3CB Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 2.684e-07 0.38
PAK1_HUMAN PAK1 Serine/threonine-protein kinase PAK 1 3.146e-07 0.42
BMR1B_HUMAN BMPR1B Bone morphogenetic protein receptor type-1B 4.122e-07 0.56
AVR2B_HUMAN ACVR2B Activin receptor type-2B 4.575e-07 0.33
ACHA7_RAT Chrna7 Neuronal acetylcholine receptor subunit alpha-7 4.688e-07 0.36
FRK_HUMAN FRK Tyrosine-protein kinase FRK 4.709e-07 0.46
KS6A3_HUMAN RPS6KA3 Ribosomal protein S6 kinase alpha-3 4.96e-07 0.46
DGAT2_HUMAN DGAT2 Diacylglycerol O-acyltransferase 2 5.941e-07 0.32
C3SLB7_ECOLX glmU Bifunctional protein GlmU 7.034e-07 0.33
RIPK1_HUMAN RIPK1 Receptor-interacting serine/threonine-protein kinase 1 9.494e-07 0.43
MAT1_HUMAN MNAT1 CDK-activating kinase assembly factor MAT1 9.911e-07 0.32
WEE2_HUMAN WEE2 Wee1-like protein kinase 2 1.016e-06 0.28
SLK_HUMAN SLK STE20-like serine/threonine-protein kinase 1.116e-06 0.46
NTRK3_HUMAN NTRK3 NT-3 growth factor receptor 1.299e-06 0.46
GTR1_HUMAN SLC2A1 Solute carrier family 2, facilitated glucose transporter member 1 1.454e-06 0.39
P3C2B_HUMAN PIK3C2B Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta 1.655e-06 0.33
KS6A2_HUMAN RPS6KA2 Ribosomal protein S6 kinase alpha-2 1.675e-06 0.32
DDR2_HUMAN DDR2 Discoidin domain-containing receptor 2 1.874e-06 0.30
MARK3_HUMAN MARK3 MAP/microtubule affinity-regulating kinase 3 2.302e-06 0.46
Q8VBU5_MOUSE Pde4b Phosphodiesterase 2.681e-06 0.34
PK3CD_HUMAN PIK3CD Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 3.046e-06 0.36
PHKG2_HUMAN PHKG2 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 3.36e-06 0.46
O97467_PLAFA ht1 Hexose transporter 1 3.502e-06 0.39
FER_HUMAN FER Tyrosine-protein kinase Fer 3.868e-06 0.46
BLK_HUMAN BLK Tyrosine-protein kinase Blk 4.359e-06 0.46
NEK6_HUMAN NEK6 Serine/threonine-protein kinase Nek6 4.928e-06 0.28
SHH_MOUSE Shh Sonic hedgehog protein 5.449e-06 0.42
P96830_MYCTO TYR_PHOSPHATASE_2 domain-containing protein 6.522e-06 0.30
LUCI_AQULA Luciferin 4-monooxygenase 6.644e-06 0.29
AK1C3_HUMAN AKR1C3 Aldo-keto reductase family 1 member C3 6.875e-06 0.30
LUCI_PHOPY Luciferin 4-monooxygenase 8.383e-06 0.35
PTK6_HUMAN PTK6 Protein-tyrosine kinase 6 8.413e-06 0.42

SGI-1776 free base

PIM1_HUMAN PIM1 Serine/threonine-protein kinase pim-1 4.807e-43 1.00
PIM2_HUMAN PIM2 Serine/threonine-protein kinase pim-2 2.179e-17 1.00
HASP_HUMAN HASPIN Serine/threonine-protein kinase haspin 5.218e-15 1.00
YES_HUMAN YES1 Tyrosine-protein kinase Yes 8.475e-07 1.00
KCNH2_HUMAN KCNH2 Potassium voltage-gated channel subfamily H member 2 4.68e-05 1.00
PIM3_HUMAN PIM3 Serine/threonine-protein kinase pim-3 7.923e-05 1.00
FLT3_HUMAN FLT3 Receptor-type tyrosine-protein kinase FLT3 8.052e-05 1.00
CLK2_MOUSE Clk2 Dual specificity protein kinase CLK2 4.369e-124 0.47
CLK4_MOUSE Clk4 Dual specificity protein kinase CLK4 9.222e-122 0.47
O96214_PLAFA pk7 Protein kinase domain-containing protein 6.301e-108 0.52
CLK1_MOUSE Clk1 Dual specificity protein kinase CLK1 4.065e-84 0.47
CLK3_MOUSE Clk3 Dual specificity protein kinase CLK3 2.345e-73 0.40
DYRK2_HUMAN DYRK2 Dual specificity tyrosine-phosphorylation-regulated kinase 2 1.013e-68 0.47
MKNK1_HUMAN MKNK1 MAP kinase-interacting serine/threonine-protein kinase 1 1.418e-54 0.43
SC5A1_HUMAN SLC5A1 Sodium/glucose cotransporter 1 6.147e-54 0.40
IKKB_HUMAN IKBKB Inhibitor of nuclear factor kappa-B kinase subunit beta 2.082e-42 0.49
DYRK3_HUMAN DYRK3 Dual specificity tyrosine-phosphorylation-regulated kinase 3 5.963e-42 0.45
SCYL1_MOUSE Scyl1 N-terminal kinase-like protein 7.545e-40 0.32
DYR1B_HUMAN DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B 3.064e-34 0.47
FGFR3_HUMAN FGFR3 Fibroblast growth factor receptor 3 4.824e-32 0.38
CCNT1_HUMAN CCNT1 Cyclin-T1 3.199e-24 0.47
ABL1_HUMAN ABL1 Tyrosine-protein kinase ABL1 9.604e-23 0.37
DYR1A_HUMAN DYRK1A Dual specificity tyrosine-phosphorylation-regulated kinase 1A 4.148e-21 0.47
CDPK4_PLAF7 CPK4 Calcium-dependent protein kinase 4 4.879e-18 0.29
WNK3_HUMAN WNK3 Serine/threonine-protein kinase WNK3 9.056e-18 0.28
PDE4D_HUMAN PDE4D cAMP-specific 3',5'-cyclic phosphodiesterase 4D 1.046e-17 0.34
NTRK3_HUMAN NTRK3 NT-3 growth factor receptor 1.561e-17 0.42
CDK9_HUMAN CDK9 Cyclin-dependent kinase 9 5.158e-17 0.47
PYRD_HUMAN DHODH Dihydroorotate dehydrogenase (quinone), mitochondrial 1.11e-16 0.39
ANM6_HUMAN PRMT6 Protein arginine N-methyltransferase 6 2.22e-16 0.36
O13428_CANAX GSC1 Beta-1,3-glucan synthase catalytic subunit 1 3.331e-16 0.31
ACH10_RAT Chrna10 Neuronal acetylcholine receptor subunit alpha-10 7.772e-16 0.34
CD5R1_HUMAN CDK5R1 Cyclin-dependent kinase 5 activator 1 7.772e-16 0.43
TIE1_HUMAN TIE1 Tyrosine-protein kinase receptor Tie-1 9.77e-15 0.37
TRPC5_HUMAN TRPC5 Short transient receptor potential channel 5 1.155e-14 0.31
NTRK2_HUMAN NTRK2 BDNF/NT-3 growth factors receptor 2.42e-14 0.42
CARM1_HUMAN CARM1 Histone-arginine methyltransferase CARM1 1.287e-13 0.36
KIFC1_HUMAN KIFC1 Kinesin-like protein KIFC1 2.154e-12 0.34
FGR_HUMAN FGR Tyrosine-protein kinase Fgr 2.702e-12 0.37
VGFR2_HUMAN KDR Vascular endothelial growth factor receptor 2 3.163e-12 0.38
CETP_HUMAN CETP Cholesteryl ester transfer protein 4.664e-12 0.36
CCNA2_HUMAN CCNA2 Cyclin-A2 5.404e-12 0.43
NEK2_HUMAN NEK2 Serine/threonine-protein kinase Nek2 1.739e-11 0.35
SC6A5_HUMAN SLC6A5 Sodium- and chloride-dependent glycine transporter 2 2.135e-11 0.33
CDK5_HUMAN CDK5 Cyclin-dependent-like kinase 5 7.408e-11 0.43
KCNJ3_RAT Kcnj3 G protein-activated inward rectifier potassium channel 1 1.003e-10 0.38
KCNJ5_RAT Kcnj5 G protein-activated inward rectifier potassium channel 4 1.003e-10 0.38
CASR_RAT Casr Extracellular calcium-sensing receptor 1.29e-10 0.33
GALR2_HUMAN GALR2 Galanin receptor type 2 1.399e-10 0.31
TTK_HUMAN TTK Dual specificity protein kinase TTK 1.831e-10 0.36
GPR39_MOUSE Gpr39 G-protein coupled receptor 39 4.349e-10 0.34
PKNB_MYCTU pknB Serine/threonine-protein kinase PknB 5.457e-09 0.37
WNK1_HUMAN WNK1 Serine/threonine-protein kinase WNK1 2.078e-08 0.30
DGAT1_MOUSE Dgat1 Diacylglycerol O-acyltransferase 1 2.801e-08 0.33
CDPK1_PLAF7 CPK1 Calcium-dependent protein kinase 1 4.574e-08 0.46
RIPK3_HUMAN RIPK3 Receptor-interacting serine/threonine-protein kinase 3 5.192e-08 0.28
SHH_MOUSE Shh Sonic hedgehog protein 1.127e-07 0.32
ACPS_BACSU acpS Holo-[acyl-carrier-protein] synthase 1.47e-07 0.31
PYRD_RAT Dhodh Dihydroorotate dehydrogenase (quinone), mitochondrial 2.941e-07 0.32
NTRK1_HUMAN NTRK1 High affinity nerve growth factor receptor 3.074e-07 0.42
CRCM1_RAT Orai1 Calcium release-activated calcium channel protein 1 2.047e-06 0.31
FAAH1_HUMAN FAAH Fatty-acid amide hydrolase 1 2.313e-06 0.33
BRAF_HUMAN BRAF Serine/threonine-protein kinase B-raf 3.244e-06 0.37
GALR1_HUMAN GALR1 Galanin receptor type 1 3.598e-06 0.32
STIM1_HUMAN STIM1 Stromal interaction molecule 1 3.608e-06 0.31
LUCI_AQULA Luciferin 4-monooxygenase 3.933e-06 0.30
PYRD_MOUSE Dhodh Dihydroorotate dehydrogenase (quinone), mitochondrial 5.743e-06 0.32
NMDE2_HUMAN GRIN2B Glutamate receptor ionotropic, NMDA 2B 6.338e-06 0.32
ABL2_HUMAN ABL2 Tyrosine-protein kinase ABL2 6.503e-06 0.29
BMX_HUMAN BMX Cytoplasmic tyrosine-protein kinase BMX 7.869e-06 0.37

TP0903

UFO_HUMAN AXL Tyrosine-protein kinase receptor UFO 1.341e-39 1.00
AURKA_HUMAN AURKA Aurora kinase A 2.789e-29 1.00
AURKB_HUMAN AURKB Aurora kinase B 6.78e-19 1.00
ALK_HUMAN ALK ALK tyrosine kinase receptor 6.867e-160 0.57
INSR_HUMAN INSR Insulin receptor 1.605e-95 0.57
STAT6_HUMAN STAT6 Signal transducer and activator of transcription 6 1.247e-92 0.42
SRC_CHICK SRC Proto-oncogene tyrosine-protein kinase Src 8.391e-86 0.51
FAK1_HUMAN PTK2 Focal adhesion kinase 1 4.815e-70 0.45
PGFRB_MOUSE Pdgfrb Platelet-derived growth factor receptor beta 1.808e-68 0.51
AMYP_PIG AMY2 Pancreatic alpha-amylase 5.16e-68 0.37
INSR_RAT Insr Insulin receptor 7.743e-57 0.45
WEE1_HUMAN WEE1 Wee1-like protein kinase 4.229e-56 0.45
ABL1_MOUSE Abl1 Tyrosine-protein kinase ABL1 2.514e-49 0.39
JAK3_HUMAN JAK3 Tyrosine-protein kinase JAK3 2.159e-48 0.45
ETV6_HUMAN ETV6 Transcription factor ETV6 5.083e-48 0.38
PMYT1_HUMAN PKMYT1 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase 1.893e-46 0.44
SRC_HUMAN SRC Proto-oncogene tyrosine-protein kinase Src 1.024e-37 0.45
ZAP70_HUMAN ZAP70 Tyrosine-protein kinase ZAP-70 1.227e-37 0.45
PAK1_HUMAN PAK1 Serine/threonine-protein kinase PAK 1 4.712e-36 0.45
SNRK_HUMAN SNRK SNF-related serine/threonine-protein kinase 6.904e-35 0.45
ACK1_HUMAN TNK2 Activated CDC42 kinase 1 3.972e-34 0.45
WEE2_HUMAN WEE2 Wee1-like protein kinase 2 4.828e-34 0.35
IGF1R_HUMAN IGF1R Insulin-like growth factor 1 receptor 4.952e-34 0.57
M3K7_HUMAN MAP3K7 Mitogen-activated protein kinase kinase kinase 7 2.335e-33 0.53
JAK2_HUMAN JAK2 Tyrosine-protein kinase JAK2 2.331e-30 0.47
FAK2_HUMAN PTK2B Protein-tyrosine kinase 2-beta 2.809e-30 0.45
CCNA1_HUMAN CCNA1 Cyclin-A1 3.491e-29 0.38
ROS1_HUMAN ROS1 Proto-oncogene tyrosine-protein kinase ROS 8.037e-29 0.51
FGFR1_HUMAN FGFR1 Fibroblast growth factor receptor 1 2.891e-28 0.51
NEK3_HUMAN NEK3 Serine/threonine-protein kinase Nek3 3.833e-28 0.45
ST32C_HUMAN STK32C Serine/threonine-protein kinase 32C 3.92e-28 0.45
MK07_HUMAN MAPK7 Mitogen-activated protein kinase 7 3.064e-27 0.45
SRC_MOUSE Src Neuronal proto-oncogene tyrosine-protein kinase Src 4.488e-27 0.32
CCND2_HUMAN CCND2 G1/S-specific cyclin-D2 5.566e-27 0.34
COQ8A_HUMAN COQ8A Atypical kinase COQ8A, mitochondrial 6.173e-27 0.45
MET_HUMAN MET Hepatocyte growth factor receptor 1.216e-26 0.56
Q9HUN3_PSEAE dnaB Replicative DNA helicase 1.626e-26 0.32
SIK2_HUMAN SIK2 Serine/threonine-protein kinase SIK2 2.704e-26 0.45
LCK_HUMAN LCK Tyrosine-protein kinase Lck 3.128e-26 0.45
DCLK2_HUMAN DCLK2 Serine/threonine-protein kinase DCLK2 4.399e-26 0.45
MYT1_HUMAN MYT1 Myelin transcription factor 1 8.092e-26 0.32
M3K10_HUMAN MAP3K10 Mitogen-activated protein kinase kinase kinase 10 1.716e-25 0.45
EGFR_HUMAN EGFR Epidermal growth factor receptor 1.925e-25 0.45
TF7L2_HUMAN TCF7L2 Transcription factor 7-like 2 3.535e-25 0.32
COQ8B_HUMAN COQ8B Atypical kinase COQ8B, mitochondrial 2.043e-24 0.45
SBK3_HUMAN SBK3 Uncharacterized serine/threonine-protein kinase SBK3 2.043e-24 0.45
SIK3_HUMAN SIK3 Serine/threonine-protein kinase SIK3 2.043e-24 0.45
STK38_HUMAN STK38 Serine/threonine-protein kinase 38 5.509e-24 0.45
MARK4_HUMAN MARK4 MAP/microtubule affinity-regulating kinase 4 2.226e-23 0.45
NIM1_HUMAN NIM1K Serine/threonine-protein kinase NIM1 2.285e-23 0.45
CTNB1_HUMAN CTNNB1 Catenin beta-1 3.204e-23 0.32
CDK1_HUMAN CDK1 Cyclin-dependent kinase 1 3.811e-23 0.45
CSF1R_HUMAN CSF1R Macrophage colony-stimulating factor 1 receptor 3.906e-23 0.45
CCNE2_HUMAN CCNE2 G1/S-specific cyclin-E2 1.234e-22 0.35
LRRK2_HUMAN LRRK2 Leucine-rich repeat serine/threonine-protein kinase 2 7.03e-22 0.45
TSSK1_HUMAN TSSK1B Testis-specific serine/threonine-protein kinase 1 2.821e-21 0.45
NEK9_HUMAN NEK9 Serine/threonine-protein kinase Nek9 4.041e-21 0.45
AVR2A_HUMAN ACVR2A Activin receptor type-2A 5e-21 0.45
ST32B_HUMAN STK32B Serine/threonine-protein kinase 32B 5e-21 0.45
NEK6_HUMAN NEK6 Serine/threonine-protein kinase Nek6 5.408e-21 0.45
PGFRB_HUMAN PDGFRB Platelet-derived growth factor receptor beta 8.187e-21 0.45
CDK2_HUMAN CDK2 Cyclin-dependent kinase 2 9.088e-21 0.45
NEK11_HUMAN NEK11 Serine/threonine-protein kinase Nek11 1.564e-20 0.34
M3K4_HUMAN MAP3K4 Mitogen-activated protein kinase kinase kinase 4 4.135e-20 0.45
TNK1_HUMAN TNK1 Non-receptor tyrosine-protein kinase TNK1 5.046e-20 0.45
PGFRA_HUMAN PDGFRA Platelet-derived growth factor receptor alpha 5.052e-20 0.45
CSKP_HUMAN CASK Peripheral plasma membrane protein CASK 5.466e-20 0.45
STK39_HUMAN STK39 STE20/SPS1-related proline-alanine-rich protein kinase 5.466e-20 0.45
DCLK1_HUMAN DCLK1 Serine/threonine-protein kinase DCLK1 5.516e-20 0.45
CHKA_HUMAN CHKA Choline kinase alpha 6.663e-20 0.33
MK09_HUMAN MAPK9 Mitogen-activated protein kinase 9 1.054e-19 0.45
VGFR3_HUMAN FLT4 Vascular endothelial growth factor receptor 3 1.196e-19 0.45
VGFR2_HUMAN KDR Vascular endothelial growth factor receptor 2 9.477e-19 0.45
CCND1_HUMAN CCND1 G1/S-specific cyclin-D1 1.676e-18 0.38
EPHA8_HUMAN EPHA8 Ephrin type-A receptor 8 2.759e-18 0.39
NMT_ASPFU nmt1 Glycylpeptide N-tetradecanoyltransferase 3.286e-18 0.31
ALK_MOUSE Alk ALK tyrosine kinase receptor 3.711e-18 0.45
M3K6_HUMAN MAP3K6 Mitogen-activated protein kinase kinase kinase 6 3.711e-18 0.45
NEK7_HUMAN NEK7 Serine/threonine-protein kinase Nek7 3.905e-18 0.45
MELK_HUMAN MELK Maternal embryonic leucine zipper kinase 4.204e-18 0.45
MK06_HUMAN MAPK6 Mitogen-activated protein kinase 6 7.722e-18 0.34
CDPK1_PLAF7 CPK1 Calcium-dependent protein kinase 1 8.1e-18 0.45
STK25_HUMAN STK25 Serine/threonine-protein kinase 25 8.1e-18 0.45
MRCKB_HUMAN CDC42BPB Serine/threonine-protein kinase MRCK beta 8.103e-18 0.45
MRCKG_HUMAN CDC42BPG Serine/threonine-protein kinase MRCK gamma 8.103e-18 0.45
ST32A_HUMAN STK32A Serine/threonine-protein kinase 32A 8.103e-18 0.45
KKCC2_HUMAN CAMKK2 Calcium/calmodulin-dependent protein kinase kinase 2 1.003e-17 0.45
SRMS_HUMAN SRMS Tyrosine-protein kinase Srms 1.293e-17 0.45
MK10_HUMAN MAPK10 Mitogen-activated protein kinase 10 1.387e-17 0.45
MP2K2_HUMAN MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 1.465e-17 0.45
M3K2_HUMAN MAP3K2 Mitogen-activated protein kinase kinase kinase 2 1.523e-17 0.45
FLT3_HUMAN FLT3 Receptor-type tyrosine-protein kinase FLT3 1.775e-17 0.45
ABL2_HUMAN ABL2 Tyrosine-protein kinase ABL2 2.084e-17 0.45
PRP4B_HUMAN PRPF4B Serine/threonine-protein kinase PRP4 homolog 2.309e-17 0.45
CDK4_HUMAN CDK4 Cyclin-dependent kinase 4 2.381e-17 0.45
STK36_HUMAN STK36 Serine/threonine-protein kinase 36 2.408e-17 0.45
MK15_HUMAN MAPK15 Mitogen-activated protein kinase 15 3.126e-17 0.45
FGR_HUMAN FGR Tyrosine-protein kinase Fgr 4.967e-17 0.45
CDK15_HUMAN CDK15 Cyclin-dependent kinase 15 1.11e-16 0.45
LTK_HUMAN LTK Leukocyte tyrosine kinase receptor 1.11e-16 0.45
MP2K1_HUMAN MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 2.22e-16 0.51
NUAK1_HUMAN NUAK1 NUAK family SNF1-like kinase 1 2.22e-16 0.45
TYRO3_HUMAN TYRO3 Tyrosine-protein kinase receptor TYRO3 2.22e-16 0.45
YES_HUMAN YES1 Tyrosine-protein kinase Yes 2.22e-16 0.45
FYN_HUMAN FYN Tyrosine-protein kinase Fyn 3.331e-16 0.45
ULK1_HUMAN ULK1 Serine/threonine-protein kinase ULK1 3.331e-16 0.45
KCC1G_HUMAN CAMK1G Calcium/calmodulin-dependent protein kinase type 1G 4.441e-16 0.45
SBK1_HUMAN SBK1 Serine/threonine-protein kinase SBK1 4.441e-16 0.45
ULK2_HUMAN ULK2 Serine/threonine-protein kinase ULK2 7.772e-16 0.45
CCNB2_HUMAN CCNB2 G2/mitotic-specific cyclin-B2 8.882e-16 0.35
CCNB3_HUMAN CCNB3 G2/mitotic-specific cyclin-B3 8.882e-16 0.35
MP2K3_HUMAN MAP2K3 Dual specificity mitogen-activated protein kinase kinase 3 9.992e-16 0.45
CSF1R_MOUSE Csf1r Macrophage colony-stimulating factor 1 receptor 1.221e-15 0.35
TBK1_MOUSE Tbk1 Serine/threonine-protein kinase TBK1 1.665e-15 0.31
PAK6_HUMAN PAK6 Serine/threonine-protein kinase PAK 6 1.776e-15 0.45
RIPK4_HUMAN RIPK4 Receptor-interacting serine/threonine-protein kinase 4 1.776e-15 0.45
M3K3_HUMAN MAP3K3 Mitogen-activated protein kinase kinase kinase 3 2.109e-15 0.45
MP2K4_HUMAN MAP2K4 Dual specificity mitogen-activated protein kinase kinase 4 2.109e-15 0.45
CDK7_HUMAN CDK7 Cyclin-dependent kinase 7 3.22e-15 0.45
ERBB4_HUMAN ERBB4 Receptor tyrosine-protein kinase erbB-4 3.22e-15 0.45
M3K11_HUMAN MAP3K11 Mitogen-activated protein kinase kinase kinase 11 4.219e-15 0.45
AVR2B_HUMAN ACVR2B Activin receptor type-2B 4.663e-15 0.45
STK24_HUMAN STK24 Serine/threonine-protein kinase 24 4.663e-15 0.45
MATK_HUMAN MATK Megakaryocyte-associated tyrosine-protein kinase 5.107e-15 0.45
CILK1_HUMAN CILK1 Serine/threonine-protein kinase ICK 5.773e-15 0.45
INSRR_HUMAN INSRR Insulin receptor-related protein 5.773e-15 0.45
TSSK2_HUMAN TSSK2 Testis-specific serine/threonine-protein kinase 2 8.105e-15 0.45
SIK1_HUMAN SIK1 Serine/threonine-protein kinase SIK1 9.326e-15 0.45
TAOK2_HUMAN TAOK2 Serine/threonine-protein kinase TAO2 9.326e-15 0.45
PGK1_HUMAN PGK1 Phosphoglycerate kinase 1 1.033e-14 0.33
LGUL_HUMAN GLO1 Lactoylglutathione lyase 1.532e-14 0.40
BRSK2_HUMAN BRSK2 Serine/threonine-protein kinase BRSK2 1.599e-14 0.45
DUSTY_HUMAN DSTYK Dual serine/threonine and tyrosine protein kinase 1.721e-14 0.45
LATS2_HUMAN LATS2 Serine/threonine-protein kinase LATS2 1.721e-14 0.45
PAK2_HUMAN PAK2 Serine/threonine-protein kinase PAK 2 1.821e-14 0.45
NEK5_HUMAN NEK5 Serine/threonine-protein kinase Nek5 1.91e-14 0.34
MYLK2_HUMAN MYLK2 Myosin light chain kinase 2, skeletal/cardiac muscle 2.176e-14 0.34
LYAM3_HUMAN SELP P-selectin 3.32e-14 0.31
EPHA4_HUMAN EPHA4 Ephrin type-A receptor 4 3.464e-14 0.45
M4K3_HUMAN MAP4K3 Mitogen-activated protein kinase kinase kinase kinase 3 3.464e-14 0.45
PKN1_HUMAN PKN1 Serine/threonine-protein kinase N1 4.263e-14 0.45
M3K15_HUMAN MAP3K15 Mitogen-activated protein kinase kinase kinase 15 4.297e-14 0.45
CDK17_HUMAN CDK17 Cyclin-dependent kinase 17 4.696e-14 0.45
M3K13_HUMAN MAP3K13 Mitogen-activated protein kinase kinase kinase 13 4.696e-14 0.45
KPCD3_HUMAN PRKD3 Serine/threonine-protein kinase D3 4.918e-14 0.45
PGFRA_MOUSE Pdgfra Platelet-derived growth factor receptor alpha 5.385e-14 0.39
EPHA3_HUMAN EPHA3 Ephrin type-A receptor 3 5.64e-14 0.45
STK26_HUMAN STK26 Serine/threonine-protein kinase 26 6.35e-14 0.45
PLK2_HUMAN PLK2 Serine/threonine-protein kinase PLK2 7.849e-14 0.45
CDK19_HUMAN CDK19 Cyclin-dependent kinase 19 8.671e-14 0.45
O97467_PLAFA ht1 Hexose transporter 1 9.492e-14 0.49
M4K1_HUMAN MAP4K1 Mitogen-activated protein kinase kinase kinase kinase 1 1.135e-13 0.45
ANKK1_HUMAN ANKK1 Ankyrin repeat and protein kinase domain-containing protein 1 1.188e-13 0.45
MARK1_HUMAN MARK1 Serine/threonine-protein kinase MARK1 1.188e-13 0.45
PAK5_HUMAN PAK5 Serine/threonine-protein kinase PAK 5 1.188e-13 0.45
PI51A_HUMAN PIP5K1A Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha 1.188e-13 0.45
TAOK1_HUMAN TAOK1 Serine/threonine-protein kinase TAO1 1.313e-13 0.45
TBK1_HUMAN TBK1 Serine/threonine-protein kinase TBK1 1.313e-13 0.45
MP2K6_HUMAN MAP2K6 Dual specificity mitogen-activated protein kinase kinase 6 1.347e-13 0.45
ABL1_HUMAN ABL1 Tyrosine-protein kinase ABL1 1.353e-13 0.45
KCC1D_HUMAN CAMK1D Calcium/calmodulin-dependent protein kinase type 1D 1.898e-13 0.45
EPHA1_HUMAN EPHA1 Ephrin type-A receptor 1 1.973e-13 0.45
EPHB1_HUMAN EPHB1 Ephrin type-B receptor 1 1.973e-13 0.45
CCNK_HUMAN CCNK Cyclin-K 2.048e-13 0.36
KCC2D_HUMAN CAMK2D Calcium/calmodulin-dependent protein kinase type II subunit delta 2.318e-13 0.45
M3K9_HUMAN MAP3K9 Mitogen-activated protein kinase kinase kinase 9 2.418e-13 0.45
MUSK_HUMAN MUSK Muscle, skeletal receptor tyrosine-protein kinase 2.814e-13 0.45
LYN_HUMAN LYN Tyrosine-protein kinase Lyn 2.949e-13 0.45
ACV1B_HUMAN ACVR1B Activin receptor type-1B 3.346e-13 0.45
EPHA6_HUMAN EPHA6 Ephrin type-A receptor 6 3.346e-13 0.45
KAPCB_HUMAN PRKACB cAMP-dependent protein kinase catalytic subunit beta 3.353e-13 0.45
ST38L_HUMAN STK38L Serine/threonine-protein kinase 38-like 3.353e-13 0.45
ST17A_HUMAN STK17A Serine/threonine-protein kinase 17A 3.416e-13 0.45
BMR1A_HUMAN BMPR1A Bone morphogenetic protein receptor type-1A 3.449e-13 0.45
MK04_HUMAN MAPK4 Mitogen-activated protein kinase 4 3.922e-13 0.29
AURKA_MOUSE Aurka Aurora kinase A 4.607e-13 0.28
NTRK2_HUMAN NTRK2 BDNF/NT-3 growth factors receptor 4.922e-13 0.45
TXK_HUMAN TXK Tyrosine-protein kinase TXK 5.44e-13 0.45
BMR1B_HUMAN BMPR1B Bone morphogenetic protein receptor type-1B 5.547e-13 0.45
EPHB2_HUMAN EPHB2 Ephrin type-B receptor 2 5.547e-13 0.45
KKCC1_HUMAN CAMKK1 Calcium/calmodulin-dependent protein kinase kinase 1 6.279e-13 0.45
RIOK3_HUMAN RIOK3 Serine/threonine-protein kinase RIO3 6.279e-13 0.45
ULK3_HUMAN ULK3 Serine/threonine-protein kinase ULK3 6.279e-13 0.45
O61059_LEIME LmGT2 Glucose transporter 7.637e-13 0.49
CCND3_HUMAN CCND3 G1/S-specific cyclin-D3 7.766e-13 0.34
STK35_HUMAN STK35 Serine/threonine-protein kinase 35 8.228e-13 0.45
FRK_HUMAN FRK Tyrosine-protein kinase FRK 8.488e-13 0.45
MK08_HUMAN MAPK8 Mitogen-activated protein kinase 8 9.122e-13 0.45
RON_HUMAN MST1R Macrophage-stimulating protein receptor 1.159e-12 0.45
BMPR2_HUMAN BMPR2 Bone morphogenetic protein receptor type-2 1.329e-12 0.45
DMPK_HUMAN DMPK Myotonin-protein kinase 1.329e-12 0.45
SRPK3_HUMAN SRPK3 SRSF protein kinase 3 1.329e-12 0.45
TIE1_HUMAN TIE1 Tyrosine-protein kinase receptor Tie-1 1.432e-12 0.45
Q388H8_TRYB2 Glycylpeptide N-tetradecanoyltransferase 1.866e-12 0.35
PI42C_HUMAN PIP4K2C Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma 2.188e-12 0.45
GAK_HUMAN GAK Cyclin-G-associated kinase 2.408e-12 0.45
GRK4_HUMAN GRK4 G protein-coupled receptor kinase 4 2.681e-12 0.45
HCK_HUMAN HCK Tyrosine-protein kinase HCK 2.926e-12 0.45
S47A2_HUMAN SLC47A2 Multidrug and toxin extrusion protein 2 4.004e-12 0.39
M3K11_MOUSE Map3k11 Mitogen-activated protein kinase kinase kinase 11 4.628e-12 0.29
EPHB6_HUMAN EPHB6 Ephrin type-B receptor 6 5.177e-12 0.45
DCLK3_HUMAN DCLK3 Serine/threonine-protein kinase DCLK3 5.182e-12 0.45
IRAK3_HUMAN IRAK3 Interleukin-1 receptor-associated kinase 3 5.182e-12 0.45
ACVR1_HUMAN ACVR1 Activin receptor type-1 5.686e-12 0.45
MYLK3_HUMAN MYLK3 Myosin light chain kinase 3 6.058e-12 0.34
KCC4_HUMAN CAMK4 Calcium/calmodulin-dependent protein kinase type IV 8.585e-12 0.45
MAST1_HUMAN MAST1 Microtubule-associated serine/threonine-protein kinase 1 8.585e-12 0.45
MYO3A_HUMAN MYO3A Myosin-IIIa 8.585e-12 0.45
OXSR1_HUMAN OXSR1 Serine/threonine-protein kinase OSR1 8.585e-12 0.45
NMT1_HUMAN NMT1 Glycylpeptide N-tetradecanoyltransferase 1 8.766e-12 0.35
EPHA7_HUMAN EPHA7 Ephrin type-A receptor 7 9.635e-12 0.45
PHKG1_HUMAN PHKG1 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 9.635e-12 0.45
GSK3A_HUMAN GSK3A Glycogen synthase kinase-3 alpha 1.106e-11 0.45
TESK1_HUMAN TESK1 Dual specificity testis-specific protein kinase 1 1.434e-11 0.34
MINK1_HUMAN MINK1 Misshapen-like kinase 1 1.5e-11 0.45
GRK7_HUMAN GRK7 Rhodopsin kinase GRK7 1.729e-11 0.45
PAK3_HUMAN PAK3 Serine/threonine-protein kinase PAK 3 2.175e-11 0.45
KCC2A_HUMAN CAMK2A Calcium/calmodulin-dependent protein kinase type II subunit alpha 2.246e-11 0.45
FES_HUMAN FES Tyrosine-protein kinase Fes/Fps 2.549e-11 0.45
PAK4_HUMAN PAK4 Serine/threonine-protein kinase PAK 4 2.7e-11 0.45
NEK4_HUMAN NEK4 Serine/threonine-protein kinase Nek4 3.153e-11 0.45
KC1AL_HUMAN CSNK1A1L Casein kinase I isoform alpha-like 3.175e-11 0.45
MYO3B_HUMAN MYO3B Myosin-IIIb 3.175e-11 0.45
MP2K5_HUMAN MAP2K5 Dual specificity mitogen-activated protein kinase kinase 5 3.274e-11 0.45
KIT_HUMAN KIT Mast/stem cell growth factor receptor Kit 3.75e-11 0.45
RIOK2_HUMAN RIOK2 Serine/threonine-protein kinase RIO2 3.973e-11 0.34
PRKX_HUMAN PRKX cAMP-dependent protein kinase catalytic subunit PRKX 4.21e-11 0.45
AAPK1_HUMAN PRKAA1 5'-AMP-activated protein kinase catalytic subunit alpha-1 4.842e-11 0.45
STK4_HUMAN STK4 Serine/threonine-protein kinase 4 5.031e-11 0.45
BMP2K_HUMAN BMP2K BMP-2-inducible protein kinase 5.071e-11 0.45
DAPK2_HUMAN DAPK2 Death-associated protein kinase 2 5.071e-11 0.45
KS6A6_HUMAN RPS6KA6 Ribosomal protein S6 kinase alpha-6 5.071e-11 0.45
BLK_HUMAN BLK Tyrosine-protein kinase Blk 5.187e-11 0.45
GTR1_HUMAN SLC2A1 Solute carrier family 2, facilitated glucose transporter member 1 6.17e-11 0.49
STK10_HUMAN STK10 Serine/threonine-protein kinase 10 6.287e-11 0.45
M4K5_HUMAN MAP4K5 Mitogen-activated protein kinase kinase kinase kinase 5 6.491e-11 0.45
STK16_HUMAN STK16 Serine/threonine-protein kinase 16 8.33e-11 0.45
E2AK4_HUMAN EIF2AK4 eIF-2-alpha kinase GCN2 8.575e-11 0.45
EPHA5_HUMAN EPHA5 Ephrin type-A receptor 5 8.697e-11 0.45
M3K20_HUMAN MAP3K20 Mitogen-activated protein kinase kinase kinase 20 9.852e-11 0.45
KCC1A_HUMAN CAMK1 Calcium/calmodulin-dependent protein kinase type 1 1.177e-10 0.45
DAPK1_HUMAN DAPK1 Death-associated protein kinase 1 1.335e-10 0.45
NUAK2_HUMAN NUAK2 NUAK family SNF1-like kinase 2 1.335e-10 0.45
DAPK3_HUMAN DAPK3 Death-associated protein kinase 3 1.572e-10 0.45
CLK2_HUMAN CLK2 Dual specificity protein kinase CLK2 1.94e-10 0.45
HIPK3_HUMAN HIPK3 Homeodomain-interacting protein kinase 3 2.091e-10 0.45
M4K4_HUMAN MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4 2.144e-10 0.45
EPHB3_HUMAN EPHB3 Ephrin type-B receptor 3 2.381e-10 0.45
NTRK3_HUMAN NTRK3 NT-3 growth factor receptor 2.527e-10 0.45
HUNK_HUMAN HUNK Hormonally up-regulated neu tumor-associated kinase 2.8e-10 0.45
M3K1_HUMAN MAP3K1 Mitogen-activated protein kinase kinase kinase 1 2.8e-10 0.45
IKKE_HUMAN IKBKE Inhibitor of nuclear factor kappa-B kinase subunit epsilon 3.077e-10 0.45
HIPK4_HUMAN HIPK4 Homeodomain-interacting protein kinase 4 3.306e-10 0.45
BTK_HUMAN BTK Tyrosine-protein kinase BTK 3.716e-10 0.45
PLK1_HUMAN PLK1 Serine/threonine-protein kinase PLK1 3.963e-10 0.45
PHKG2_HUMAN PHKG2 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 3.977e-10 0.45
CDK16_HUMAN CDK16 Cyclin-dependent kinase 16 4.822e-10 0.45
FER_HUMAN FER Tyrosine-protein kinase Fer 5.617e-10 0.45
M3K19_HUMAN MAP3K19 Mitogen-activated protein kinase kinase kinase 19 5.87e-10 0.45
MARK3_HUMAN MARK3 MAP/microtubule affinity-regulating kinase 3 6.046e-10 0.45
SRPK1_HUMAN SRPK1 SRSF protein kinase 1 6.712e-10 0.45
CCNE1_HUMAN CCNE1 G1/S-specific cyclin-E1 6.827e-10 0.36
LATS1_HUMAN LATS1 Serine/threonine-protein kinase LATS1 7.014e-10 0.45
PLK3_HUMAN PLK3 Serine/threonine-protein kinase PLK3 7.133e-10 0.45
BRSK1_HUMAN BRSK1 Serine/threonine-protein kinase BRSK1 7.355e-10 0.45
JAK3_MOUSE Jak3 Tyrosine-protein kinase JAK3 7.541e-10 0.29
A1Z199_HUMAN BCR/ABL fusion BCR/ABL p210 fusion protein 8.714e-10 0.39
M4K2_HUMAN MAP4K2 Mitogen-activated protein kinase kinase kinase kinase 2 8.781e-10 0.45
RET_HUMAN RET Proto-oncogene tyrosine-protein kinase receptor Ret 9.274e-10 0.45
DDR2_HUMAN DDR2 Discoidin domain-containing receptor 2 1.144e-09 0.45
CDK6_HUMAN CDK6 Cyclin-dependent kinase 6 1.161e-09 0.38
TNIK_HUMAN TNIK TRAF2 and NCK-interacting protein kinase 1.268e-09 0.45
AURKC_HUMAN AURKC Aurora kinase C 1.287e-09 0.45
DDR1_HUMAN DDR1 Epithelial discoidin domain-containing receptor 1 1.417e-09 0.45
KAPCA_HUMAN PRKACA cAMP-dependent protein kinase catalytic subunit alpha 1.535e-09 0.45
TLK2_HUMAN TLK2 Serine/threonine-protein kinase tousled-like 2 1.898e-09 0.34
TEC_HUMAN TEC Tyrosine-protein kinase Tec 1.96e-09 0.45
HIPK1_HUMAN HIPK1 Homeodomain-interacting protein kinase 1 2.082e-09 0.45
DYR1B_HUMAN DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B 2.217e-09 0.45
GPR6_HUMAN GPR6 G-protein coupled receptor 6 2.691e-09 0.35
5HT6R_HUMAN HTR6 5-hydroxytryptamine receptor 6 3.447e-09 0.38
PTK6_HUMAN PTK6 Protein-tyrosine kinase 6 4.685e-09 0.45
CCNB1_HUMAN CCNB1 G2/mitotic-specific cyclin-B1 5.009e-09 0.35
AAK1_HUMAN AAK1 AP2-associated protein kinase 1 5.379e-09 0.45
CDKL5_HUMAN CDKL5 Cyclin-dependent kinase-like 5 5.811e-09 0.34
RIPK2_HUMAN RIPK2 Receptor-interacting serine/threonine-protein kinase 2 6.222e-09 0.45
SLK_HUMAN SLK STE20-like serine/threonine-protein kinase 7.474e-09 0.45
DLK1_HUMAN DLK1 Protein delta homolog 1 7.778e-09 0.29
KS6A3_HUMAN RPS6KA3 Ribosomal protein S6 kinase alpha-3 8.747e-09 0.45
TGFR2_HUMAN TGFBR2 TGF-beta receptor type-2 8.957e-09 0.45
IRAK1_HUMAN IRAK1 Interleukin-1 receptor-associated kinase 1 1e-08 0.45
CSK_HUMAN CSK Tyrosine-protein kinase CSK 1.268e-08 0.45
KCC2G_HUMAN CAMK2G Calcium/calmodulin-dependent protein kinase type II subunit gamma 1.326e-08 0.45
VGFR1_HUMAN FLT1 Vascular endothelial growth factor receptor 1 1.509e-08 0.45
CLK4_HUMAN CLK4 Dual specificity protein kinase CLK4 1.558e-08 0.45
TLR9_HUMAN TLR9 Toll-like receptor 9 1.921e-08 0.30
NEK2_HUMAN NEK2 Serine/threonine-protein kinase Nek2 2.166e-08 0.45
KPCT_HUMAN PRKCQ Protein kinase C theta type 2.244e-08 0.45
STK3_HUMAN STK3 Serine/threonine-protein kinase 3 2.49e-08 0.45
KS6A4_HUMAN RPS6KA4 Ribosomal protein S6 kinase alpha-4 2.685e-08 0.45
WNK1_HUMAN WNK1 Serine/threonine-protein kinase WNK1 2.966e-08 0.29
PKN2_HUMAN PKN2 Serine/threonine-protein kinase N2 3.555e-08 0.45
SRPK2_HUMAN SRPK2 SRSF protein kinase 2 3.642e-08 0.34
STK11_HUMAN STK11 Serine/threonine-protein kinase STK11 3.642e-08 0.34
TLK1_HUMAN TLK1 Serine/threonine-protein kinase tousled-like 1 3.642e-08 0.34
JAK1_HUMAN JAK1 Tyrosine-protein kinase JAK1 3.953e-08 0.45
MYLK_HUMAN MYLK Myosin light chain kinase, smooth muscle 4.026e-08 0.45
MARK2_HUMAN MARK2 Serine/threonine-protein kinase MARK2 6.711e-08 0.45
TNI3K_HUMAN TNNI3K Serine/threonine-protein kinase TNNI3K 6.711e-08 0.45
TYK2_HUMAN TYK2 Non-receptor tyrosine-protein kinase TYK2 7.307e-08 0.45
HIPK2_HUMAN HIPK2 Homeodomain-interacting protein kinase 2 7.563e-08 0.45
BRDT_HUMAN BRDT Bromodomain testis-specific protein 7.75e-08 0.39
KCC2B_HUMAN CAMK2B Calcium/calmodulin-dependent protein kinase type II subunit beta 9.511e-08 0.45
CCNA2_HUMAN CCNA2 Cyclin-A2 1.068e-07 0.35
MERTK_HUMAN MERTK Tyrosine-protein kinase Mer 1.243e-07 0.45
FAAH1_HUMAN FAAH Fatty-acid amide hydrolase 1 1.286e-07 0.33
GSTO1_HUMAN GSTO1 Glutathione S-transferase omega-1 1.445e-07 0.31
KPCD2_HUMAN PRKD2 Serine/threonine-protein kinase D2 1.465e-07 0.45
STK33_HUMAN STK33 Serine/threonine-protein kinase 33 1.475e-07 0.45
SGK3_HUMAN SGK3 Serine/threonine-protein kinase Sgk3 1.553e-07 0.34
SHH_MOUSE Shh Sonic hedgehog protein 2.104e-07 0.39
GRK1_HUMAN GRK1 Rhodopsin kinase GRK1 2.36e-07 0.45
PLK4_HUMAN PLK4 Serine/threonine-protein kinase PLK4 2.427e-07 0.45
CDK18_HUMAN CDK18 Cyclin-dependent kinase 18 2.884e-07 0.34
ACVL1_HUMAN ACVRL1 Serine/threonine-protein kinase receptor R3 2.887e-07 0.45
CAC1G_HUMAN CACNA1G Voltage-dependent T-type calcium channel subunit alpha-1G 3.426e-07 0.34
NR4A2_HUMAN NR4A2 Nuclear receptor subfamily 4 group A member 2 3.447e-07 0.29
KSYK_HUMAN SYK Tyrosine-protein kinase SYK 4.852e-07 0.45
MK14_HUMAN MAPK14 Mitogen-activated protein kinase 14 5.294e-07 0.37
TIE2_HUMAN TEK Angiopoietin-1 receptor 5.422e-07 0.45
IKKA_HUMAN CHUK Inhibitor of nuclear factor kappa-B kinase subunit alpha 5.898e-07 0.34
MK12_HUMAN MAPK12 Mitogen-activated protein kinase 12 6.03e-07 0.45
LIMK1_HUMAN LIMK1 LIM domain kinase 1 6.255e-07 0.45
MK01_HUMAN MAPK1 Mitogen-activated protein kinase 1 7.74e-07 0.51
MYLK4_HUMAN MYLK4 Myosin light chain kinase family member 4 8.455e-07 0.34
TAOK3_HUMAN TAOK3 Serine/threonine-protein kinase TAO3 8.653e-07 0.45
MRCKA_HUMAN CDC42BPA Serine/threonine-protein kinase MRCK alpha 8.876e-07 0.45
STA5A_HUMAN STAT5A Signal transducer and activator of transcription 5A 1.106e-06 0.28
S22A2_HUMAN SLC22A2 Solute carrier family 22 member 2 1.111e-06 0.39
IKKB_HUMAN IKBKB Inhibitor of nuclear factor kappa-B kinase subunit beta 1.129e-06 0.34
PKNB_MYCTU pknB Serine/threonine-protein kinase PknB 1.169e-06 0.45
CDK14_HUMAN CDK14 Cyclin-dependent kinase 14 1.354e-06 0.34
PI42B_HUMAN PIP4K2B Phosphatidylinositol 5-phosphate 4-kinase type-2 beta 1.354e-06 0.34
EPHA2_HUMAN EPHA2 Ephrin type-A receptor 2 1.393e-06 0.45
SYK_HUMAN KARS1 Lysine--tRNA ligase 1.628e-06 0.45
TTK_HUMAN TTK Dual specificity protein kinase TTK 2.103e-06 0.45
PI4KB_HUMAN PI4KB Phosphatidylinositol 4-kinase beta 2.179e-06 0.45
BMX_HUMAN BMX Cytoplasmic tyrosine-protein kinase BMX 2.191e-06 0.45
S47A1_HUMAN SLC47A1 Multidrug and toxin extrusion protein 1 2.278e-06 0.39
AAPK2_HUMAN PRKAA2 5'-AMP-activated protein kinase catalytic subunit alpha-2 2.802e-06 0.45
KGP1_HUMAN PRKG1 cGMP-dependent protein kinase 1 3.264e-06 0.45
CDKL2_HUMAN CDKL2 Cyclin-dependent kinase-like 2 4.535e-06 0.34
KC1A_HUMAN CSNK1A1 Casein kinase I isoform alpha 4.809e-06 0.45
DYRK4_HUMAN DYRK4 Dual specificity tyrosine-phosphorylation-regulated kinase 4 4.866e-06 0.45
DYR1A_HUMAN DYRK1A Dual specificity tyrosine-phosphorylation-regulated kinase 1A 5.618e-06 0.45
ST17B_HUMAN STK17B Serine/threonine-protein kinase 17B 5.958e-06 0.45
CDK9_HUMAN CDK9 Cyclin-dependent kinase 9 6.379e-06 0.45
RIOK1_HUMAN RIOK1 Serine/threonine-protein kinase RIO1 6.419e-06 0.34
ERBB2_HUMAN ERBB2 Receptor tyrosine-protein kinase erbB-2 6.852e-06 0.45
GRK5_HUMAN GRK5 G protein-coupled receptor kinase 5 7.08e-06 0.45
KCNJ6_HUMAN KCNJ6 G protein-activated inward rectifier potassium channel 2 7.202e-06 0.32
KGP2_HUMAN PRKG2 cGMP-dependent protein kinase 2 7.986e-06 0.45
Q0GMK6_RABIT CDK4 Cyclin-dependent kinase 4 9.991e-06 0.29

Momelotinib

JAK2_MOUSE Jak2 Tyrosine-protein kinase JAK2 4.629e-39 1.00
JAK2_HUMAN JAK2 Tyrosine-protein kinase JAK2 1.263e-38 1.00
JAK3_HUMAN JAK3 Tyrosine-protein kinase JAK3 4.13e-38 1.00
BMR1A_HUMAN BMPR1A Bone morphogenetic protein receptor type-1A 1.377e-17 1.00
BMR1B_HUMAN BMPR1B Bone morphogenetic protein receptor type-1B 4.142e-12 1.00
ACVR1_HUMAN ACVR1 Activin receptor type-1 1.197e-10 1.00
JAK1_HUMAN JAK1 Tyrosine-protein kinase JAK1 1.256e-08 1.00
TGFR1_HUMAN TGFBR1 TGF-beta receptor type-1 0.0001316 1.00
IKKE_HUMAN IKBKE Inhibitor of nuclear factor kappa-B kinase subunit epsilon 7.807e-217 0.58
TBK1_HUMAN TBK1 Serine/threonine-protein kinase TBK1 2.784e-199 0.58
SMG1_HUMAN SMG1 Serine/threonine-protein kinase SMG1 3.278e-141 0.49
KSYK_HUMAN SYK Tyrosine-protein kinase SYK 4.732e-109 0.49
STAT6_HUMAN STAT6 Signal transducer and activator of transcription 6 1.163e-100 0.42
CATK_RABIT CTSK Cathepsin K 1.296e-97 0.49
NEMO_HUMAN IKBKG NF-kappa-B essential modulator 1.117e-96 0.42
CCND2_HUMAN CCND2 G1/S-specific cyclin-D2 1.004e-85 0.37
PRIO_SHEEP PRNP Major prion protein 2.832e-81 0.41
MTOR_HUMAN MTOR Serine/threonine-protein kinase mTOR 4.914e-76 0.46
INSR_HUMAN INSR Insulin receptor 9.369e-68 0.49
BCR_HUMAN BCR Breakpoint cluster region protein 1.883e-58 0.37
CCND3_HUMAN CCND3 G1/S-specific cyclin-D3 1.11e-57 0.42
IGF1R_HUMAN IGF1R Insulin-like growth factor 1 receptor 1.163e-57 0.47
MK10_HUMAN MAPK10 Mitogen-activated protein kinase 10 2.765e-54 0.53
CDK4_HUMAN CDK4 Cyclin-dependent kinase 4 1.85e-52 0.51
MTOR_RAT Mtor Serine/threonine-protein kinase mTOR 8.867e-52 0.34
CDK2_HUMAN CDK2 Cyclin-dependent kinase 2 8.981e-51 0.51
CCND1_HUMAN CCND1 G1/S-specific cyclin-D1 9.627e-51 0.41
JAK3_MOUSE Jak3 Tyrosine-protein kinase JAK3 1.116e-49 0.51
IKKB_HUMAN IKBKB Inhibitor of nuclear factor kappa-B kinase subunit beta 5.296e-48 0.56
IKKA_HUMAN CHUK Inhibitor of nuclear factor kappa-B kinase subunit alpha 1.583e-47 0.45
RAF1_HUMAN RAF1 RAF proto-oncogene serine/threonine-protein kinase 1.775e-46 0.38
PK3CA_HUMAN PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 1.978e-46 0.41
ERBB2_HUMAN ERBB2 Receptor tyrosine-protein kinase erbB-2 2.277e-42 0.47
FAK1_HUMAN PTK2 Focal adhesion kinase 1 2.841e-38 0.47
MAPK5_HUMAN MAPKAPK5 MAP kinase-activated protein kinase 5 2.99e-38 0.40
SHH_MOUSE Shh Sonic hedgehog protein 1.677e-37 0.51
PK3CG_HUMAN PIK3CG Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 1.466e-36 0.41
ZAP70_HUMAN ZAP70 Tyrosine-protein kinase ZAP-70 1.717e-36 0.47
DKK1_HUMAN DKK1 Dickkopf-related protein 1 3.016e-36 0.33
HSPB1_HUMAN HSPB1 Heat shock protein beta-1 2.809e-35 0.40
AURKA_HUMAN AURKA Aurora kinase A 2.909e-34 0.51
BRAF_HUMAN BRAF Serine/threonine-protein kinase B-raf 1.068e-33 0.38
MK08_HUMAN MAPK8 Mitogen-activated protein kinase 8 1.86e-32 0.53
PGFRA_HUMAN PDGFRA Platelet-derived growth factor receptor alpha 2.559e-32 0.56
CATB_HUMAN CTSB Cathepsin B 2.625e-32 0.49
CDK1_HUMAN CDK1 Cyclin-dependent kinase 1 3.917e-32 0.49
CCNA2_HUMAN CCNA2 Cyclin-A2 5.989e-32 0.42
SO2A1_RAT Slco2a1 Solute carrier organic anion transporter family member 2A1 1.491e-31 0.31
CCNH_HUMAN CCNH Cyclin-H 2.113e-31 0.37
CCNB1_HUMAN CCNB1 G2/mitotic-specific cyclin-B1 3.045e-31 0.39
LRRK2_HUMAN LRRK2 Leucine-rich repeat serine/threonine-protein kinase 2 6.599e-31 0.42
CDK7_HUMAN CDK7 Cyclin-dependent kinase 7 5.269e-30 0.44
MK10_RAT Mapk10 Mitogen-activated protein kinase 10 1.357e-29 0.48
EPHB4_HUMAN EPHB4 Ephrin type-B receptor 4 3.627e-29 0.39
HPGDS_HUMAN HPGDS Hematopoietic prostaglandin D synthase 9.277e-28 0.43
FLT3_HUMAN FLT3 Receptor-type tyrosine-protein kinase FLT3 3.951e-27 0.56
MP2K1_HUMAN MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 4.743e-27 0.42
KIT_HUMAN KIT Mast/stem cell growth factor receptor Kit 5.208e-27 0.56
FAK2_HUMAN PTK2B Protein-tyrosine kinase 2-beta 1.779e-26 0.40
MK14_HUMAN MAPK14 Mitogen-activated protein kinase 14 2.114e-26 0.42
KPCD1_HUMAN PRKD1 Serine/threonine-protein kinase D1 2.981e-26 0.44
MK09_HUMAN MAPK9 Mitogen-activated protein kinase 9 5.624e-26 0.49
EGFR_HUMAN EGFR Epidermal growth factor receptor 1.688e-25 0.49
LCK_HUMAN LCK Tyrosine-protein kinase Lck 5.05e-25 0.49
CCNA1_HUMAN CCNA1 Cyclin-A1 1.004e-24 0.39
CCNE2_HUMAN CCNE2 G1/S-specific cyclin-E2 2.154e-24 0.37
NCOR1_HUMAN NCOR1 Nuclear receptor corepressor 1 2.297e-24 0.35
ABL1_HUMAN ABL1 Tyrosine-protein kinase ABL1 2.806e-24 0.49
PRKDC_MOUSE Prkdc DNA-dependent protein kinase catalytic subunit 2.826e-24 0.30
ALK_HUMAN ALK ALK tyrosine kinase receptor 6.099e-24 0.42
KCC2D_HUMAN CAMK2D Calcium/calmodulin-dependent protein kinase type II subunit delta 7.886e-24 0.49
CCNB2_HUMAN CCNB2 G2/mitotic-specific cyclin-B2 2.449e-23 0.37
CCNB3_HUMAN CCNB3 G2/mitotic-specific cyclin-B3 2.449e-23 0.37
Q4DCQ3_TRYCC Superoxide dismutase 5.518e-23 0.28
RIPK1_MOUSE Ripk1 Receptor-interacting serine/threonine-protein kinase 1 7.023e-23 0.35
TLR9_HUMAN TLR9 Toll-like receptor 9 2.922e-22 0.36
JUN_HUMAN JUN Transcription factor AP-1 1.123e-21 0.37
ABL1_MOUSE Abl1 Tyrosine-protein kinase ABL1 2.545e-21 0.38
MP2K1_MOUSE Map2k1 Dual specificity mitogen-activated protein kinase kinase 1 6.654e-21 0.33
ACK1_HUMAN TNK2 Activated CDC42 kinase 1 1.372e-20 0.49
TNIK_HUMAN TNIK TRAF2 and NCK-interacting protein kinase 2.965e-20 0.41
AUKBA_XENLA aurkb-a Aurora kinase B-A 3.102e-20 0.32
VGFR2_HUMAN KDR Vascular endothelial growth factor receptor 2 5.412e-20 0.56
BTK_MOUSE Btk Tyrosine-protein kinase BTK 7.437e-20 0.32
HIPK1_HUMAN HIPK1 Homeodomain-interacting protein kinase 1 9.422e-20 0.39
PMYT1_HUMAN PKMYT1 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase 9.98e-20 0.42
BTK_HUMAN BTK Tyrosine-protein kinase BTK 1.685e-19 0.46
PGFRB_HUMAN PDGFRB Platelet-derived growth factor receptor beta 2.401e-19 0.56
TTK_HUMAN TTK Dual specificity protein kinase TTK 2.706e-19 0.38
Q6DMN0_TOXGO CPL Cathepsin L 4.301e-19 0.29
M3K7_HUMAN MAP3K7 Mitogen-activated protein kinase kinase kinase 7 6.158e-19 0.39
CD63_HUMAN CD63 CD63 antigen 6.972e-19 0.35
SRC_HUMAN SRC Proto-oncogene tyrosine-protein kinase Src 1.664e-18 0.49
PAK1_HUMAN PAK1 Serine/threonine-protein kinase PAK 1 1.781e-18 0.43
LTK_HUMAN LTK Leukocyte tyrosine kinase receptor 2.273e-18 0.49
CATS_MOUSE Ctss Cathepsin S 2.838e-18 0.49
CATL1_HUMAN CTSL Cathepsin L1 2.972e-18 0.43
HGFL_HUMAN MST1 Hepatocyte growth factor-like protein 3.028e-18 0.29
AURKB_HUMAN AURKB Aurora kinase B 3.414e-18 0.51
PLK1_HUMAN PLK1 Serine/threonine-protein kinase PLK1 5.291e-18 0.45
TBK1_MOUSE Tbk1 Serine/threonine-protein kinase TBK1 2.497e-17 0.39
MP2K2_HUMAN MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 2.749e-17 0.42
CATS_HUMAN CTSS Cathepsin S 4.437e-17 0.49
RET_HUMAN RET Proto-oncogene tyrosine-protein kinase receptor Ret 4.755e-17 0.49
P85A_HUMAN PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha 4.759e-17 0.40
PK3C3_HUMAN PIK3C3 Phosphatidylinositol 3-kinase catalytic subunit type 3 1.11e-16 0.32
TAOK1_HUMAN TAOK1 Serine/threonine-protein kinase TAO1 1.11e-16 0.49
BPTF_HUMAN BPTF Nucleosome-remodeling factor subunit BPTF 2.22e-16 0.31
PDE10_RAT Pde10a cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 3.331e-16 0.34
CDK9_HUMAN CDK9 Cyclin-dependent kinase 9 5.551e-16 0.49
SCNAA_MOUSE Scn10a Sodium channel protein type 10 subunit alpha 1.665e-15 0.36
DYR1B_HUMAN DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B 1.998e-15 0.42
GSK3B_HUMAN GSK3B Glycogen synthase kinase-3 beta 2.22e-15 0.49
CSF1R_HUMAN CSF1R Macrophage colony-stimulating factor 1 receptor 3.442e-15 0.49
5HT1B_GORGO HTR1B 5-hydroxytryptamine receptor 1B 3.664e-15 0.29
FYN_HUMAN FYN Tyrosine-protein kinase Fyn 6.661e-15 0.49
NAMPT_HUMAN NAMPT Nicotinamide phosphoribosyltransferase 7.772e-15 0.41
CATK_HUMAN CTSK Cathepsin K 1.044e-14 0.49
CCNT1_HUMAN CCNT1 Cyclin-T1 1.166e-14 0.40
Q9HUN3_PSEAE dnaB Replicative DNA helicase 1.243e-14 0.32
O97467_PLAFA ht1 Hexose transporter 1 2.52e-14 0.42
M4K5_HUMAN MAP4K5 Mitogen-activated protein kinase kinase kinase kinase 5 3.053e-14 0.49
LYN_HUMAN LYN Tyrosine-protein kinase Lyn 3.764e-14 0.49
CDK6_HUMAN CDK6 Cyclin-dependent kinase 6 4.108e-14 0.42
VGFR1_HUMAN FLT1 Vascular endothelial growth factor receptor 1 9.304e-14 0.56
RON_HUMAN MST1R Macrophage-stimulating protein receptor 1.154e-13 0.42
CDKL1_HUMAN CDKL1 Cyclin-dependent kinase-like 1 1.203e-13 0.30
Q9WKE8_9HIV1 reverse transcriptase Reverse transcriptase 2.021e-13 0.36
WEE1_HUMAN WEE1 Wee1-like protein kinase 2.22e-13 0.49
GSK3A_HUMAN GSK3A Glycogen synthase kinase-3 alpha 2.559e-13 0.49
CCNE1_HUMAN CCNE1 G1/S-specific cyclin-E1 3.498e-13 0.40
DRD4_RAT Drd4 D(4) dopamine receptor 4.265e-13 0.36
GTR1_HUMAN SLC2A1 Solute carrier family 2, facilitated glucose transporter member 1 6.576e-13 0.42
FGFR1_HUMAN FGFR1 Fibroblast growth factor receptor 1 1.111e-12 0.49
KC1D_HUMAN CSNK1D Casein kinase I isoform delta 1.138e-12 0.49
M4K2_HUMAN MAP4K2 Mitogen-activated protein kinase kinase kinase kinase 2 1.228e-12 0.49
O61059_LEIME LmGT2 Glucose transporter 1.275e-12 0.42
YES_HUMAN YES1 Tyrosine-protein kinase Yes 1.278e-12 0.43
DAPK3_HUMAN DAPK3 Death-associated protein kinase 3 1.384e-12 0.49
INCE_HUMAN INCENP Inner centromere protein 1.86e-12 0.38
PE2R2_HUMAN PTGER2 Prostaglandin E2 receptor EP2 subtype 1.915e-12 0.39
KSYK_RAT Syk Tyrosine-protein kinase SYK 2.492e-12 0.33
HDAC1_HUMAN HDAC1 Histone deacetylase 1 3.102e-12 0.45
KPCD3_HUMAN PRKD3 Serine/threonine-protein kinase D3 3.434e-12 0.49
CHK1_HUMAN CHEK1 Serine/threonine-protein kinase Chk1 4.084e-12 0.49
CLK2_HUMAN CLK2 Dual specificity protein kinase CLK2 4.387e-12 0.49
ROS1_HUMAN ROS1 Proto-oncogene tyrosine-protein kinase ROS 4.955e-12 0.49
DGAT1_HUMAN DGAT1 Diacylglycerol O-acyltransferase 1 5.679e-12 0.38
DDR2_HUMAN DDR2 Discoidin domain-containing receptor 2 6.16e-12 0.38
S47A2_HUMAN SLC47A2 Multidrug and toxin extrusion protein 2 6.448e-12 0.38
O96526_LEIMA CRK3 Cdc2-related kinase 7.229e-12 0.35
M3K20_HUMAN MAP3K20 Mitogen-activated protein kinase kinase kinase 20 7.422e-12 0.49
PK3CB_HUMAN PIK3CB Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 8.093e-12 0.41
KC1E_HUMAN CSNK1E Casein kinase I isoform epsilon 8.335e-12 0.32
CLK4_HUMAN CLK4 Dual specificity protein kinase CLK4 1.756e-11 0.49
KIT_MOUSE Kit Mast/stem cell growth factor receptor Kit 2.335e-11 0.33
AAPK1_HUMAN PRKAA1 5'-AMP-activated protein kinase catalytic subunit alpha-1 3.487e-11 0.49
PAK4_HUMAN PAK4 Serine/threonine-protein kinase PAK 4 4.208e-11 0.49
M4K4_HUMAN MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4 5.018e-11 0.49
NTRK2_HUMAN NTRK2 BDNF/NT-3 growth factors receptor 5.744e-11 0.42
STK3_HUMAN STK3 Serine/threonine-protein kinase 3 5.864e-11 0.49
FRK_HUMAN FRK Tyrosine-protein kinase FRK 8.192e-11 0.49
GSK3B_RAT Gsk3b Glycogen synthase kinase-3 beta 1.212e-10 0.29
SEPR_MOUSE Fap Prolyl endopeptidase FAP 1.291e-10 0.31
HIPK4_HUMAN HIPK4 Homeodomain-interacting protein kinase 4 1.564e-10 0.49
TYK2_HUMAN TYK2 Non-receptor tyrosine-protein kinase TYK2 2.384e-10 0.56
RAC1_HUMAN RAC1 Ras-related C3 botulinum toxin substrate 1 2.891e-10 0.30
CSN5_HUMAN COPS5 COP9 signalosome complex subunit 5 3.926e-10 0.34
KC1A_HUMAN CSNK1A1 Casein kinase I isoform alpha 4.031e-10 0.49
KS6A3_HUMAN RPS6KA3 Ribosomal protein S6 kinase alpha-3 4.395e-10 0.49
PYGM_HUMAN PYGM Glycogen phosphorylase, muscle form 4.56e-10 0.34
LCK_MOUSE Lck Proto-oncogene tyrosine-protein kinase LCK 5.568e-10 0.31
NEK2_HUMAN NEK2 Serine/threonine-protein kinase Nek2 7.757e-10 0.49
MK01_HUMAN MAPK1 Mitogen-activated protein kinase 1 8.097e-10 0.39
EPHA8_HUMAN EPHA8 Ephrin type-A receptor 8 1.233e-09 0.38
AK1C3_HUMAN AKR1C3 Aldo-keto reductase family 1 member C3 1.475e-09 0.33
CETP_HUMAN CETP Cholesteryl ester transfer protein 1.477e-09 0.35
SRMS_HUMAN SRMS Tyrosine-protein kinase Srms 2.774e-09 0.39
TYRO3_HUMAN TYRO3 Tyrosine-protein kinase receptor TYRO3 5.443e-09 0.42
PGH1_SHEEP PTGS1 Prostaglandin G/H synthase 1 6.291e-09 0.43
NTRK3_HUMAN NTRK3 NT-3 growth factor receptor 7.178e-09 0.49
PDGFB_HUMAN PDGFB Platelet-derived growth factor subunit B 7.807e-09 0.48
SLK_HUMAN SLK STE20-like serine/threonine-protein kinase 8.584e-09 0.49
NK2R_MESAU TACR2 Substance-K receptor 9.622e-09 0.34
DRD3_HUMAN DRD3 D(3) dopamine receptor 1.059e-08 0.39
PK3CD_HUMAN PIK3CD Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 1.259e-08 0.36
KCC2A_HUMAN CAMK2A Calcium/calmodulin-dependent protein kinase type II subunit alpha 1.682e-08 0.49
KLK6_HUMAN KLK6 Kallikrein-6 1.968e-08 0.30
PDE10_HUMAN PDE10A cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 2.185e-08 0.34
AOC3_RAT Aoc3 Membrane primary amine oxidase 2.245e-08 0.38
EPHB3_HUMAN EPHB3 Ephrin type-B receptor 3 2.417e-08 0.31
CDK19_HUMAN CDK19 Cyclin-dependent kinase 19 2.575e-08 0.47
MARK3_HUMAN MARK3 MAP/microtubule affinity-regulating kinase 3 2.873e-08 0.49
PHKG2_HUMAN PHKG2 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 2.929e-08 0.49
AURKC_HUMAN AURKC Aurora kinase C 2.952e-08 0.49
MAPK2_HUMAN MAPKAPK2 MAP kinase-activated protein kinase 2 3.227e-08 0.32
HDAC3_HUMAN HDAC3 Histone deacetylase 3 3.334e-08 0.38
GSK3B_MOUSE Gsk3b Glycogen synthase kinase-3 beta 4.067e-08 0.30
NCOR2_HUMAN NCOR2 Nuclear receptor corepressor 2 5.632e-08 0.33
KPCD2_HUMAN PRKD2 Serine/threonine-protein kinase D2 6.027e-08 0.49
BRSK2_HUMAN BRSK2 Serine/threonine-protein kinase BRSK2 6.311e-08 0.39
FER_HUMAN FER Tyrosine-protein kinase Fer 7.456e-08 0.49
ERBB4_HUMAN ERBB4 Receptor tyrosine-protein kinase erbB-4 8.331e-08 0.43
REV1_HUMAN REV1 DNA repair protein REV1 8.352e-08 0.29
MRCKB_HUMAN CDC42BPB Serine/threonine-protein kinase MRCK beta 8.359e-08 0.31
EPHA6_HUMAN EPHA6 Ephrin type-A receptor 6 8.702e-08 0.31
HDAC8_HUMAN HDAC8 Histone deacetylase 8 9.53e-08 0.39
RIPK2_HUMAN RIPK2 Receptor-interacting serine/threonine-protein kinase 2 9.568e-08 0.32
DYR1A_HUMAN DYRK1A Dual specificity tyrosine-phosphorylation-regulated kinase 1A 1.001e-07 0.49
AOC3_HUMAN AOC3 Membrane primary amine oxidase 1.187e-07 0.38
SCNAA_HUMAN SCN10A Sodium channel protein type 10 subunit alpha 1.383e-07 0.36
BLK_HUMAN BLK Tyrosine-protein kinase Blk 1.705e-07 0.49
M3K9_HUMAN MAP3K9 Mitogen-activated protein kinase kinase kinase 9 1.923e-07 0.56
TIE1_HUMAN TIE1 Tyrosine-protein kinase receptor Tie-1 2.004e-07 0.31
WEE2_HUMAN WEE2 Wee1-like protein kinase 2 2.004e-07 0.32
AVR2B_HUMAN ACVR2B Activin receptor type-2B 2.173e-07 0.34
FES_HUMAN FES Tyrosine-protein kinase Fes/Fps 2.606e-07 0.43
DDR1_HUMAN DDR1 Epithelial discoidin domain-containing receptor 1 3.563e-07 0.38
EPHB6_HUMAN EPHB6 Ephrin type-B receptor 6 4.193e-07 0.31
ACHA7_RAT Chrna7 Neuronal acetylcholine receptor subunit alpha-7 4.253e-07 0.36
TNNC1_HUMAN TNNC1 Troponin C, slow skeletal and cardiac muscles 4.29e-07 0.31
TNNI3_HUMAN TNNI3 Troponin I, cardiac muscle 4.29e-07 0.31
TNNT2_HUMAN TNNT2 Troponin T, cardiac muscle 4.29e-07 0.31
ABL2_HUMAN ABL2 Tyrosine-protein kinase ABL2 5.205e-07 0.38
5HT1D_CAVPO HTR1D 5-hydroxytryptamine receptor 1D 7.227e-07 0.29
ADRB2_CANLF ADRB2 Beta-2 adrenergic receptor 7.374e-07 0.29
ITK_HUMAN ITK Tyrosine-protein kinase ITK/TSK 8.692e-07 0.49
UFO_HUMAN AXL Tyrosine-protein kinase receptor UFO 8.852e-07 0.43
AOFA_RAT Maoa Amine oxidase [flavin-containing] A 1.124e-06 0.34
STABP_HUMAN STAMBP STAM-binding protein 1.136e-06 0.34
NEK6_HUMAN NEK6 Serine/threonine-protein kinase Nek6 1.166e-06 0.32
CLK1_HUMAN CLK1 Dual specificity protein kinase CLK1 1.189e-06 0.40
ERN1_HUMAN ERN1 Serine/threonine-protein kinase/endoribonuclease IRE1 1.317e-06 0.38
S22A2_HUMAN SLC22A2 Solute carrier family 22 member 2 1.428e-06 0.38
SCN2A_HUMAN SCN2A Sodium channel protein type 2 subunit alpha 1.474e-06 0.33
STK10_HUMAN STK10 Serine/threonine-protein kinase 10 1.763e-06 0.31
P3C2B_HUMAN PIK3C2B Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta 1.954e-06 0.32
PLK4_HUMAN PLK4 Serine/threonine-protein kinase PLK4 1.962e-06 0.49
EPHA3_HUMAN EPHA3 Ephrin type-A receptor 3 2.107e-06 0.31
SCN9A_HUMAN SCN9A Sodium channel protein type 9 subunit alpha 2.208e-06 0.38
DPOL_VACCW POL DNA polymerase 2.423e-06 0.31
KCC2B_HUMAN CAMK2B Calcium/calmodulin-dependent protein kinase type II subunit beta 2.505e-06 0.49
HDAC2_HUMAN HDAC2 Histone deacetylase 2 2.868e-06 0.38
S47A1_HUMAN SLC47A1 Multidrug and toxin extrusion protein 1 2.891e-06 0.38
5HT2A_HUMAN HTR2A 5-hydroxytryptamine receptor 2A 2.894e-06 0.38
MYLK3_HUMAN MYLK3 Myosin light chain kinase 3 3.052e-06 0.31
Q8I5C5_PLAF7 Macrophage migration inhibitory factor 3.105e-06 0.28
ERCC1_HUMAN ERCC1 DNA excision repair protein ERCC-1 3.301e-06 0.32
XPF_HUMAN ERCC4 DNA repair endonuclease XPF 3.301e-06 0.32
RCOR1_HUMAN RCOR1 REST corepressor 1 3.571e-06 0.37
PAPA1_CARPA Papain 3.595e-06 0.31
5HT1A_RAT Htr1a 5-hydroxytryptamine receptor 1A 3.626e-06 0.38
CAH3_HUMAN CA3 Carbonic anhydrase 3 4.083e-06 0.38
PI42C_HUMAN PIP4K2C Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma 4.083e-06 0.38
KCC2G_HUMAN CAMK2G Calcium/calmodulin-dependent protein kinase type II subunit gamma 4.107e-06 0.49
VGFR3_HUMAN FLT4 Vascular endothelial growth factor receptor 3 5.499e-06 0.56
KAPCA_HUMAN PRKACA cAMP-dependent protein kinase catalytic subunit alpha 6.431e-06 0.49
CDK5_HUMAN CDK5 Cyclin-dependent-like kinase 5 6.717e-06 0.49
DRD2_HUMAN DRD2 D(2) dopamine receptor 6.814e-06 0.39
PTGDS_MOUSE Ptgds Prostaglandin-H2 D-isomerase 8.543e-06 0.29
ROCK1_HUMAN ROCK1 Rho-associated protein kinase 1 8.672e-06 0.49
FA10_HUMAN F10 Coagulation factor X 9.087e-06 0.34
A1Z199_HUMAN BCR/ABL fusion BCR/ABL p210 fusion protein 9.374e-06 0.38
MINK1_HUMAN MINK1 Misshapen-like kinase 1 9.461e-06 0.38
FGR_HUMAN FGR Tyrosine-protein kinase Fgr 9.58e-06 0.38
P96830_MYCTO TYR_PHOSPHATASE_2 domain-containing protein 9.991e-06 0.29

Givinostat

HDAC8_HUMAN HDAC8 Histone deacetylase 8 9.554e-37 1.00
HDAC6_HUMAN HDAC6 Histone deacetylase 6 2.48e-35 1.00
HDAC1_HUMAN HDAC1 Histone deacetylase 1 3.292e-28 1.00
HDAC7_HUMAN HDAC7 Histone deacetylase 7 4.411e-18 1.00
HDAC9_HUMAN HDAC9 Histone deacetylase 9 1.11e-16 1.00
HDAC5_HUMAN HDAC5 Histone deacetylase 5 3.764e-14 1.00
HDAC2_HUMAN HDAC2 Histone deacetylase 2 4.567e-13 1.00
Q9ZTP8_MAIZE hd1b Histone deacetylase 1.839e-10 1.00
HDAC3_HUMAN HDAC3 Histone deacetylase 3 8.961e-08 1.00
HDAC4_HUMAN HDAC4 Histone deacetylase 4 2.387e-06 1.00
A5H660_SCHMA HDAC8 Histone deacetylase 8 3.966e-70 0.36
KDM1B_HUMAN KDM1B Lysine-specific histone demethylase 1B 4.597e-56 0.33
O68720_YERPE yopH Targeted effector protein 7.84e-56 0.33
UROK_RAT Plau Urokinase-type plasminogen activator 2.938e-47 0.30
TF7L2_HUMAN TCF7L2 Transcription factor 7-like 2 6.899e-45 0.33
CTNB1_HUMAN CTNNB1 Catenin beta-1 2.14e-41 0.33
ENPP2_MOUSE Enpp2 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 1.081e-37 0.36
ECR_CHITE EcR Ecdysone receptor 1.627e-37 0.30
ECR_HELVI EcR Ecdysone receptor 1.627e-37 0.30
O45117_CHITE USP-1 Ultraspiracle 1.627e-37 0.30
Q6IVK1_PLOIN USP 1.627e-37 0.30
Q6RVD3_PLOIN Ecdysone receptor 1.627e-37 0.30
Q7SIF6_HELVI Gene regulation protein 1.627e-37 0.30
Q8I1M8_CHISP CsUSP Ultraspiracle 1.627e-37 0.30
Q8MYA6_CHISP CsEcR-B1 Ecdysone receptor B1 isoform 1.627e-37 0.30
Q962I5_LUCCU Ultraspiracle protein 1.627e-37 0.30
USP_CHOFU USP Protein ultraspiracle homolog 1.627e-37 0.30
THRB_MOUSE F2 Prothrombin 2.223e-37 0.30
PGDA2_BACCR Peptidoglycan-N-acetylglucosamine deacetylase BC_1974 1.948e-36 0.29
KLK2_HUMAN KLK2 Kallikrein-2 2.317e-35 0.32
UROK_HUMAN PLAU Urokinase-type plasminogen activator 3.366e-35 0.41
KLK8_HUMAN KLK8 Kallikrein-8 4.847e-32 0.32
SIR3_HUMAN SIRT3 NAD-dependent protein deacetylase sirtuin-3, mitochondrial 7.669e-31 0.36
NR1I3_HUMAN NR1I3 Nuclear receptor subfamily 1 group I member 3 5.719e-30 0.34
KLK4_HUMAN KLK4 Kallikrein-4 2.017e-29 0.32
ACRO_HUMAN ACR Acrosin 4.935e-28 0.31
TPA_HUMAN PLAT Tissue-type plasminogen activator 1.195e-27 0.37
UROK_MOUSE Plau Urokinase-type plasminogen activator 2.6e-26 0.30
GLP1R_RAT Glp1r Glucagon-like peptide 1 receptor 2.945e-26 0.30
PLMN_MOUSE Plg Plasminogen 4.628e-24 0.30
TNIK_HUMAN TNIK TRAF2 and NCK-interacting protein kinase 6.312e-23 0.31
SIR2_HUMAN SIRT2 NAD-dependent protein deacetylase sirtuin-2 4.621e-21 0.36
STK39_RAT Stk39 STE20/SPS1-related proline-alanine-rich protein kinase 1.442e-20 0.29
GIPR_RAT Gipr Gastric inhibitory polypeptide receptor 2.036e-19 0.31
PRIO_SHEEP PRNP Major prion protein 3.386e-19 0.37
TSHB_BOVIN TSHB Thyrotropin subunit beta 5.705e-19 0.30
Q4W6C8_LEPDE LdUSP Ultraspiracle 1.039e-18 0.30
Q4W6D0_LEPDE LdEcR-A Ecdysone receptor A isoform 1.039e-18 0.30
ASF1A_HUMAN ASF1A Histone chaperone ASF1A 3.615e-18 0.29
Q9GSG8_AEDAE Ultraspiracle isoform-A 1.221e-15 0.30
PLMN_HUMAN PLG Plasminogen 1.887e-15 0.41
S22A1_RAT Slc22a1 Solute carrier family 22 member 1 3.997e-15 0.39
S22A1_MOUSE Slc22a1 Solute carrier family 22 member 1 6.106e-15 0.33
SIR1_HUMAN SIRT1 NAD-dependent protein deacetylase sirtuin-1 2.143e-14 0.34
GATA4_MOUSE Gata4 Transcription factor GATA-4 1.625e-13 0.30
NKX25_MOUSE Nkx2-5 Homeobox protein Nkx-2.5 1.625e-13 0.30
GLR_HUMAN GCGR Glucagon receptor 3e-13 0.34
STA5A_HUMAN STAT5A Signal transducer and activator of transcription 5A 4.131e-13 0.29
HDAC1_MOUSE Hdac1 Histone deacetylase 1 1.664e-12 0.33
TRY1_HUMAN PRSS1 Trypsin-1 2.531e-11 0.41
LYOX_HUMAN LOX Protein-lysine 6-oxidase 4.65e-11 0.29
E3UJZ5_SPOLI Ecdysone receptor 5.773e-11 0.30
RS27_HUMAN RPS27 40S ribosomal protein S27 1.522e-10 0.28
UT1_RAT Slc14a1 Urea transporter 1 1.647e-10 0.28
USP_DROME usp Protein ultraspiracle 3.004e-10 0.30
HDA11_HUMAN HDAC11 Histone deacetylase 11 4.635e-10 0.40
RCOR1_HUMAN RCOR1 REST corepressor 1 1.061e-09 0.34
S22A2_RAT Slc22a2 Solute carrier family 22 member 2 1.148e-09 0.39
ECR_LUCCU EcR Ecdysone receptor 1.692e-09 0.30
LOX5_RAT Alox5 Arachidonate 5-lipoxygenase 4.029e-09 0.39
ERR3_HUMAN ESRRG Estrogen-related receptor gamma 4.996e-09 0.29
GLR_RAT Gcgr Glucagon receptor 6.205e-09 0.31
STA5B_HUMAN STAT5B Signal transducer and activator of transcription 5B 6.485e-09 0.29
BMP1_HUMAN BMP1 Bone morphogenetic protein 1 1.071e-08 0.33
NCEH1_HUMAN NCEH1 Neutral cholesterol ester hydrolase 1 1.192e-08 0.29
MEP1B_HUMAN MEP1B Meprin A subunit beta 1.6e-08 0.29
NOX1_HUMAN NOX1 NADPH oxidase 1 1.688e-08 0.31
ECR_DROME EcR Ecdysone receptor 1.804e-08 0.30
HDA10_HUMAN HDAC10 Polyamine deacetylase HDAC10 2.476e-08 0.40
ANDR_MOUSE Ar Androgen receptor 1.151e-07 0.33
KLK1_HUMAN KLK1 Kallikrein-1 1.404e-07 0.32
TAAR1_RAT Taar1 Trace amine-associated receptor 1 1.744e-07 0.33
ECR_BOMMO EcR Ecdysone receptor 1.783e-07 0.30
Q94F81_MAIZE hda106 HD2 type histone deacetylase HDA106 1.789e-07 0.34
GIPR_HUMAN GIPR Gastric inhibitory polypeptide receptor 1.921e-07 0.32
PPID_HUMAN PPID Peptidyl-prolyl cis-trans isomerase D 2.196e-07 0.30
POLG_DEN2P Genome polyprotein 4.405e-07 0.30
PD2R2_HUMAN PTGDR2 Prostaglandin D2 receptor 2 4.685e-07 0.43
O77240_CHOFU EcR Ecdysone receptor isoform A 1.003e-06 0.30
KCNQ2_MOUSE Kcnq2 Potassium voltage-gated channel subfamily KQT member 2 1.14e-06 0.29
KLKB1_HUMAN KLKB1 Plasma kallikrein 1.206e-06 0.37
P4HTM_HUMAN P4HTM Transmembrane prolyl 4-hydroxylase 2.033e-06 0.29
MCHR1_HUMAN MCHR1 Melanin-concentrating hormone receptor 1 2.808e-06 0.40
SENP1_HUMAN SENP1 Sentrin-specific protease 1 2.849e-06 0.29
SENP7_HUMAN SENP7 Sentrin-specific protease 7 4.384e-06 0.34
LOXL2_HUMAN LOXL2 Lysyl oxidase homolog 2 4.789e-06 0.29
LKHA4_HUMAN LTA4H Leukotriene A-4 hydrolase 4.983e-06 0.31
TGM2_HUMAN TGM2 Protein-glutamine gamma-glutamyltransferase 2 8.538e-06 0.32

Cucurbitacin B

ITAL_HUMAN ITGAL Integrin alpha-L 3.672e-12 1.00
HIF1A_HUMAN HIF1A Hypoxia-inducible factor 1-alpha 8.415e-05 1.00
PAX8_HUMAN PAX8 Paired box protein Pax-8 0.002676 1.00
STAT3_HUMAN STAT3 Signal transducer and activator of transcription 3 0.01089 1.00

Plinabulin

MK10_RAT Mapk10 Mitogen-activated protein kinase 10 1.311e-09 1.00
RAF1_HUMAN RAF1 RAF proto-oncogene serine/threonine-protein kinase 0.3913 1.00
PAI1_HUMAN SERPINE1 Plasminogen activator inhibitor 1 5.795e-14 0.40
DPYD_HUMAN DPYD Dihydropyrimidine dehydrogenase [NADP(+)] 2.757e-12 0.30

Lanatoside C

PAX8_HUMAN PAX8 Paired box protein Pax-8 2.048e-07 1.00
AT1A1_HUMAN ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 2.699e-110 0.70
NOTC1_MOUSE Notch1 Neurogenic locus notch homolog protein 1 2.051e-108 0.55
AT1A3_RAT Atp1a3 Sodium/potassium-transporting ATPase subunit alpha-3 4.078e-100 0.70
AT1A2_RAT Atp1a2 Sodium/potassium-transporting ATPase subunit alpha-2 1.372e-90 0.70
AT1A1_CANLF ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 4.846e-81 0.70
SO4C1_HUMAN SLCO4C1 Solute carrier organic anion transporter family member 4C1 8.81e-67 0.58
AT1B3_RAT Atp1b3 Sodium/potassium-transporting ATPase subunit beta-3 5.91e-53 0.42
AT1A4_RAT Atp1a4 Sodium/potassium-transporting ATPase subunit alpha-4 7.361e-39 0.70
AT1B1_RAT Atp1b1 Sodium/potassium-transporting ATPase subunit beta-1 7.361e-39 0.70
AT1A1_RAT Atp1a1 Sodium/potassium-transporting ATPase subunit alpha-1 5.811e-34 0.42
SO1A4_RAT Slco1a4 Solute carrier organic anion transporter family member 1A4 3.514e-31 0.70
AT1A1_PIG ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 6.377e-23 0.28
AMYP_HUMAN AMY2A Pancreatic alpha-amylase 7.088e-18 0.28
NOTC1_HUMAN NOTCH1 Neurogenic locus notch homolog protein 1 1.891e-12 0.37
IF4A1_MOUSE Eif4a1 Eukaryotic initiation factor 4A-I 5.427e-11 0.29
AT12A_HUMAN ATP12A Potassium-transporting ATPase alpha chain 2 2.166e-10 0.40
IL2_HUMAN IL2 Interleukin-2 3.749e-06 0.32

Everolimus

MTOR_HUMAN MTOR Serine/threonine-protein kinase mTOR 0.08786 1.00
FKB1A_MOUSE Fkbp1a Peptidyl-prolyl cis-trans isomerase FKBP1A 2.873e-239 0.89
PP2BA_HUMAN PPP3CA Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform 7.51e-114 0.39
FKB1A_HUMAN FKBP1A Peptidyl-prolyl cis-trans isomerase FKBP1A 1.095e-100 0.89
FKB1B_HUMAN FKBP1B Peptidyl-prolyl cis-trans isomerase FKBP1B 2.165e-63 0.89
PDCD4_HUMAN PDCD4 Programmed cell death protein 4 4.238e-25 0.89
SO1B1_HUMAN SLCO1B1 Solute carrier organic anion transporter family member 1B1 4.894e-25 0.89
SF3B3_HUMAN SF3B3 Splicing factor 3B subunit 3 3.241e-10 0.37
FKBP5_HUMAN FKBP5 Peptidyl-prolyl cis-trans isomerase FKBP5 4.821e-10 0.89
FKBP4_HUMAN FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4 4.793e-07 0.38

Deguelin

CP2D6_HUMAN CYP2D6 Cytochrome P450 2D6 0.7197 1.00
CP2CJ_HUMAN CYP2C19 Cytochrome P450 2C19 0.9718 1.00
DCOR_HUMAN ODC1 Ornithine decarboxylase 1.362e-80 0.65
NU4M_HUMAN MT-ND4 NADH-ubiquinone oxidoreductase chain 4 1.313e-48 0.41
NDUA4_HUMAN NDUFA4 Cytochrome c oxidase subunit NDUFA4 3.235e-13 0.32
TYRO_HUMAN TYR Tyrosinase 5.601e-10 0.37
NANH_CLOPF nanH Sialidase 3.066e-06 0.45

Bufalin

AT1A1_CANLF ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 1.256e-161 0.62
AT12A_HUMAN ATP12A Potassium-transporting ATPase alpha chain 2 5.783e-94 0.62
NOTC1_MOUSE Notch1 Neurogenic locus notch homolog protein 1 1.648e-70 0.41
AT1A1_HUMAN ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 7.572e-61 0.32
SO4C1_HUMAN SLCO4C1 Solute carrier organic anion transporter family member 4C1 2.03e-54 0.47
G6PD_HUMAN G6PD Glucose-6-phosphate 1-dehydrogenase 2.534e-53 0.43
EPHA2_MOUSE Epha2 Ephrin type-A receptor 2 2.236e-45 0.30
SMT1_ARATH SMT1 Cycloartenol-C-24-methyltransferase 2.969e-41 0.35
AT1A3_RAT Atp1a3 Sodium/potassium-transporting ATPase subunit alpha-3 9.226e-36 0.32
Q9GRG7_9TRYP g6pd Glucose-6-phosphate 1-dehydrogenase 2.716e-34 0.43
AT1A2_RAT Atp1a2 Sodium/potassium-transporting ATPase subunit alpha-2 2.108e-32 0.32
GBRA4_RAT Gabra4 Gamma-aminobutyric acid receptor subunit alpha-4 4.834e-32 0.40
CBG_HUMAN SERPINA6 Corticosteroid-binding globulin 2.833e-30 0.43
SIA4B_RAT St3gal2 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 8.427e-30 0.29
GPBAR_HUMAN GPBAR1 G-protein coupled bile acid receptor 1 3.115e-27 0.43
SHBG_RAT Shbg Sex hormone-binding globulin 1.248e-24 0.30
AT1A4_RAT Atp1a4 Sodium/potassium-transporting ATPase subunit alpha-4 1.007e-23 0.40
AT1B1_RAT Atp1b1 Sodium/potassium-transporting ATPase subunit beta-1 1.007e-23 0.40
AT1A1_PIG ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 1.313e-23 0.29
SHBG_HUMAN SHBG Sex hormone-binding globulin 1.262e-22 0.43
IF4A1_MOUSE Eif4a1 Eukaryotic initiation factor 4A-I 1.521e-22 0.32
NR1I3_MOUSE Nr1i3 Nuclear receptor subfamily 1 group I member 3 1.803e-22 0.36
CAH4_BOVIN CA4 Carbonic anhydrase 4 7.227e-19 0.33
NTCP2_HUMAN SLC10A2 Ileal sodium/bile acid cotransporter 7.772e-16 0.33
SIA4A_HUMAN ST3GAL1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 3.109e-15 0.29
SO1A4_RAT Slco1a4 Solute carrier organic anion transporter family member 1A4 1.088e-14 0.32
ABCBB_HUMAN ABCB11 Bile salt export pump 1.4e-12 0.31
NOTC1_HUMAN NOTCH1 Neurogenic locus notch homolog protein 1 2.54e-12 0.34
GABR1_RAT Gabbr1 Gamma-aminobutyric acid type B receptor subunit 1 3.829e-12 0.40
DHB3_RAT Hsd17b3 Testosterone 17-beta-dehydrogenase 3 1.351e-10 0.43
GBRD_HUMAN GABRD Gamma-aminobutyric acid receptor subunit delta 3.532e-10 0.39
NR1H4_HUMAN NR1H4 Bile acid receptor 5.644e-10 0.35
NTCP_HUMAN SLC10A1 Sodium/bile acid cotransporter 4.403e-08 0.33
SO1A1_RAT Slco1a1 Solute carrier organic anion transporter family member 1A1 4.442e-07 0.29
DPOLB_RAT Polb DNA polymerase beta 4.858e-07 0.34
CAH2_HUMAN CA2 Carbonic anhydrase 2 1.553e-06 0.33
CAH1_HUMAN CA1 Carbonic anhydrase 1 3.812e-06 0.33
DHB3_HUMAN HSD17B3 Testosterone 17-beta-dehydrogenase 3 6.824e-06 0.43

Gramicidin

EDNRA_PIG EDNRA Endothelin-1 receptor 2.989e-126 0.58
V2R_PIG AVPR2 Vasopressin V2 receptor 1.898e-116 0.38
HDAC6_MOUSE Hdac6 Histone deacetylase 6 2.262e-100 0.49
GALR1_RAT Galr1 Galanin receptor type 1 6.963e-92 0.45
GALR2_RAT Galr2 Galanin receptor type 2 6.963e-92 0.45
ADAM8_HUMAN ADAM8 Disintegrin and metalloproteinase domain-containing protein 8 8.479e-86 0.38
HDAC5_MOUSE Hdac5 Histone deacetylase 5 5.479e-83 0.48
GHRL_HUMAN GHRL Appetite-regulating hormone 1.057e-82 0.38
MC4R_MOUSE Mc4r Melanocortin receptor 4 1.163e-77 0.67
HDAC8_MOUSE Hdac8 Histone deacetylase 8 7.48e-72 0.48
MTLR_HUMAN MLNR Motilin receptor 1.853e-70 0.44
OXYR_RAT Oxtr Oxytocin receptor 5.675e-69 0.65
SSR5_RAT Sstr5 Somatostatin receptor type 5 6.586e-65 0.38
BKRB2_RABIT BDKRB2 B2 bradykinin receptor 1.915e-60 0.39
MEN1_HUMAN MEN1 Menin 5.469e-59 0.48
ACKR3_HUMAN ACKR3 Atypical chemokine receptor 3 5.157e-58 0.52
MC3R_MOUSE Mc3r Melanocortin receptor 3 6.764e-58 0.64
AGRA_STAAU agrA Accessory gene regulator protein A 2.204e-53 0.37
CXCR4_HUMAN CXCR4 C-X-C chemokine receptor type 4 2.118e-52 0.46
V2R_RAT Avpr2 Vasopressin V2 receptor 2.694e-50 0.65
V2R_BOVIN AVPR2 Vasopressin V2 receptor 4.011e-45 0.28
CHIB_SERMA chiB Chitinase B 4.406e-42 0.39
Q2HXR2_TOXGO PNP Purine nucleoside phosphorylase 6.045e-41 0.32
NK2R_MESAU TACR2 Substance-K receptor 2.307e-40 0.36
V1AR_RAT Avpr1a Vasopressin V1a receptor 5.984e-38 0.65
Q5D7U5_CHICK OXTR Oxytocin-like receptor 4.749e-37 0.29
HDAC4_HUMAN HDAC4 Histone deacetylase 4 1.926e-36 0.52
NK2R_RABIT TACR2 Substance-K receptor 5.132e-36 0.36
GHSR_HUMAN GHSR Growth hormone secretagogue receptor type 1 6.316e-35 0.51
PPIA_HUMAN PPIA Peptidyl-prolyl cis-trans isomerase A 8.06e-35 0.33
O07911_STAAU agrC AgrC 1.672e-34 0.38
ITA5_HUMAN ITGA5 Integrin alpha-5 8.782e-34 0.44
SSR2_HUMAN SSTR2 Somatostatin receptor type 2 1.01e-33 0.63
ITAV_HUMAN ITGAV Integrin alpha-V 4.264e-33 0.46
MC5R_HUMAN MC5R Melanocortin receptor 5 2.121e-32 0.42
OXYR_HUMAN OXTR Oxytocin receptor 1.246e-31 0.56
C5AR1_HUMAN C5AR1 C5a anaphylatoxin chemotactic receptor 1 2.647e-31 0.41
MC5R_MOUSE Mc5r Melanocortin receptor 5 3.625e-31 0.48
BIRC3_HUMAN BIRC3 Baculoviral IAP repeat-containing protein 3 1.585e-30 0.44
NCOR2_HUMAN NCOR2 Nuclear receptor corepressor 2 3.053e-30 0.41
ITB5_HUMAN ITGB5 Integrin beta-5 2.504e-29 0.46
SSR4_HUMAN SSTR4 Somatostatin receptor type 4 3.508e-29 0.63
MSHR_MOUSE Mc1r Melanocyte-stimulating hormone receptor 3.727e-29 0.52
UR2R_RAT Uts2r Urotensin-2 receptor 9.252e-28 0.40
NK2R_RAT Tacr2 Substance-K receptor 2.893e-27 0.39
ITB3_HUMAN ITGB3 Integrin beta-3 1.343e-26 0.46
IDE_MOUSE Ide Insulin-degrading enzyme 1.863e-26 0.33
GRB2_HUMAN GRB2 Growth factor receptor-bound protein 2 2.188e-25 0.45
SOAT1_CHLAE SOAT1 Sterol O-acyltransferase 1 3.37e-24 0.39
EDNRB_PIG EDNRB Endothelin receptor type B 9.425e-24 0.56
HDAC1_MOUSE Hdac1 Histone deacetylase 1 1.619e-23 0.55
CLPP_ECOLI clpP ATP-dependent Clp protease proteolytic subunit 7.47e-23 0.28
CBPN_HUMAN CPN1 Carboxypeptidase N catalytic chain 6.525e-22 0.38
NCOR1_HUMAN NCOR1 Nuclear receptor corepressor 1 4.059e-21 0.39
HDA11_HUMAN HDAC11 Histone deacetylase 11 4.227e-20 0.41
OXYR_MOUSE Oxtr Oxytocin receptor 3.333e-19 0.31
HDAC3_HUMAN HDAC3 Histone deacetylase 3 1.458e-18 0.57
HDAC1_HUMAN HDAC1 Histone deacetylase 1 1.609e-18 0.55
SSR2_MOUSE Sstr2 Somatostatin receptor type 2 6.307e-18 0.34
SSR5_HUMAN SSTR5 Somatostatin receptor type 5 1.504e-17 0.63
NK3R_RAT Tacr3 Neuromedin-K receptor 1.638e-17 0.39
V1BR_HUMAN AVPR1B Vasopressin V1b receptor 1.707e-17 0.35
MC3R_HUMAN MC3R Melanocortin receptor 3 2.894e-17 0.42
SSR3_HUMAN SSTR3 Somatostatin receptor type 3 3.195e-17 0.63
ITA2B_HUMAN ITGA2B Integrin alpha-IIb 1.11e-16 0.44
HDA10_HUMAN HDAC10 Polyamine deacetylase HDAC10 2.22e-16 0.41
SSR1_HUMAN SSTR1 Somatostatin receptor type 1 2.22e-16 0.63
V2R_HUMAN AVPR2 Vasopressin V2 receptor 2.22e-16 0.36
MSHR_HUMAN MC1R Melanocyte-stimulating hormone receptor 9.992e-16 0.39
OST48_HUMAN DDOST Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit 1.11e-15 0.31
OPRM_RAT Oprm1 Mu-type opioid receptor 9.992e-15 0.51
HDAC6_HUMAN HDAC6 Histone deacetylase 6 3.464e-14 0.52
ENV_HV1H2 env Envelope glycoprotein gp160 4.774e-14 0.31
ITB6_HUMAN ITGB6 Integrin beta-6 5.329e-14 0.43
UR2R_HUMAN UTS2R Urotensin-2 receptor 5.629e-14 0.53
CHIB1_ASPFM chiB1 Endochitinase B1 3.922e-13 0.29
OPRD_RAT Oprd1 Delta-type opioid receptor 4.364e-13 0.40
P96830_MYCTO TYR_PHOSPHATASE_2 domain-containing protein 4.503e-13 0.39
HDAC8_HUMAN HDAC8 Histone deacetylase 8 7.204e-13 0.46
NK2R_HUMAN TACR2 Substance-K receptor 2.172e-12 0.36
V1AR_HUMAN AVPR1A Vasopressin V1a receptor 9.106e-12 0.35
A0A286XTF2_CAVPO OPRD1 G_PROTEIN_RECEP_F1_2 domain-containing protein 9.542e-12 0.50
CAN2_HUMAN CAPN2 Calpain-2 catalytic subunit 9.834e-12 0.33
OPRD_MOUSE Oprd1 Delta-type opioid receptor 2.173e-11 0.50
TRY1_BOVIN Cationic trypsin 2.207e-11 0.47
ITB1_HUMAN ITGB1 Integrin beta-1 2.784e-11 0.44
NK1R_HUMAN TACR1 Substance-P receptor 1.268e-10 0.61
V1BR_RAT Avpr1b Vasopressin V1b receptor 1.604e-10 0.35
HDAC2_HUMAN HDAC2 Histone deacetylase 2 2.223e-10 0.52
HDAC1_RAT Hdac1 Histone deacetylase 1 3.547e-10 0.51
MC4R_HUMAN MC4R Melanocortin receptor 4 4.499e-10 0.42
NMD3A_RAT Grin3a Glutamate receptor ionotropic, NMDA 3A 5.732e-10 0.29
COLA_CLOPE colA Collagenase ColA 7.21e-10 0.41
CHIA_SERMA chiA Chitinase A 7.541e-10 0.29
SOAT2_CHLAE SOAT2 Sterol O-acyltransferase 2 2.391e-09 0.35
PPCE_BOVIN PREP Prolyl endopeptidase 2.851e-09 0.29
IDE_HUMAN IDE Insulin-degrading enzyme 3.134e-09 0.37
OPRM_CAVPO OPRM1 Mu-type opioid receptor 3.819e-09 0.50
NK1R_CAVPO TACR1 Substance-P receptor 5.259e-09 0.36
PIN1_HUMAN PIN1 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 7.802e-09 0.48
MRP2_RAT Abcc2 Canalicular multispecific organic anion transporter 1 1.207e-08 0.39
CBPA1_HUMAN CPA1 Carboxypeptidase A1 8.996e-08 0.34
EDNRA_HUMAN EDNRA Endothelin-1 receptor 1.206e-07 0.74
Q9S446_STAAU srtA Class A sortase SrtA 2.558e-07 0.38
Q94F81_MAIZE hda106 HD2 type histone deacetylase HDA106 1.629e-06 0.55
Q9XYC7_PLAFA HDAC1 Histone deacetylase 2.768e-06 0.40
RENI_RAT Ren1 Renin 3.057e-06 0.34
HDAH_ALCSD hdaH Histone deacetylase-like amidohydrolase 3.736e-06 0.40
CBPB2_HUMAN CPB2 Carboxypeptidase B2 8.491e-06 0.38

Celastrol

SIDA_ASPFU sidA L-ornithine N(5)-monooxygenase 1.825e-84 0.68
DHI2_RAT Hsd11b2 Corticosteroid 11-beta-dehydrogenase isozyme 2 3.774e-44 0.35
RGS17_HUMAN RGS17 Regulator of G-protein signaling 17 1.316e-41 0.68
DHI2_HUMAN HSD11B2 Corticosteroid 11-beta-dehydrogenase isozyme 2 1.74e-20 0.37
R1AB_SARS rep Replicase polyprotein 1ab 6.013e-20 0.68
DHI2_MOUSE Hsd11b2 Corticosteroid 11-beta-dehydrogenase isozyme 2 2.376e-14 0.31
TERT_HUMAN TERT Telomerase reverse transcriptase 1.262e-07 0.68
HSF1_HUMAN HSF1 Heat shock factor protein 1 1.38e-07 0.68
MGLL_RAT Mgll Monoglyceride lipase 5.26e-07 0.57
EST2_HUMAN CES2 Cocaine esterase 1.565e-06 0.32

Cinobufagin

AT1A1_CANLF ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 3.165e-80 0.42
AT12A_HUMAN ATP12A Potassium-transporting ATPase alpha chain 2 4.569e-78 0.42
NOTC1_MOUSE Notch1 Neurogenic locus notch homolog protein 1 2.027e-66 0.35
G6PD_HUMAN G6PD Glucose-6-phosphate 1-dehydrogenase 5.859e-55 0.39
SO4C1_HUMAN SLCO4C1 Solute carrier organic anion transporter family member 4C1 1.437e-39 0.34
SMT1_ARATH SMT1 Cycloartenol-C-24-methyltransferase 2.206e-36 0.30
Q9GRG7_9TRYP g6pd Glucose-6-phosphate 1-dehydrogenase 1.388e-29 0.37
TAT_HV112 tat Protein Tat 1.709e-29 0.29
GBRA4_RAT Gabra4 Gamma-aminobutyric acid receptor subunit alpha-4 8.472e-29 0.34
CBG_HUMAN SERPINA6 Corticosteroid-binding globulin 1.84e-22 0.38
GPBAR_HUMAN GPBAR1 G-protein coupled bile acid receptor 1 3.034e-21 0.37
IF4A1_MOUSE Eif4a1 Eukaryotic initiation factor 4A-I 3.227e-21 0.30
NR1I3_MOUSE Nr1i3 Nuclear receptor subfamily 1 group I member 3 1.507e-19 0.31
SHBG_HUMAN SHBG Sex hormone-binding globulin 2.448e-12 0.37
ABCBB_HUMAN ABCB11 Bile salt export pump 8.394e-12 0.29
EPHA2_MOUSE Epha2 Ephrin type-A receptor 2 1.482e-11 0.28
GABR1_RAT Gabbr1 Gamma-aminobutyric acid type B receptor subunit 1 3.944e-11 0.39
CAH4_BOVIN CA4 Carbonic anhydrase 4 8.499e-11 0.31
GBRD_HUMAN GABRD Gamma-aminobutyric acid receptor subunit delta 2.791e-10 0.39
DHB3_RAT Hsd17b3 Testosterone 17-beta-dehydrogenase 3 3.281e-09 0.37
NR1H4_HUMAN NR1H4 Bile acid receptor 5.16e-09 0.33
NTCP_HUMAN SLC10A1 Sodium/bile acid cotransporter 1.537e-07 0.31
DPOLB_RAT Polb DNA polymerase beta 1.454e-06 0.31
Q8I5C5_PLAF7 Macrophage migration inhibitory factor 3.047e-06 0.28

Selinexor

XPO1_HUMAN XPO1 Exportin-1 1.913e-73 0.44
TRPC1_HUMAN TRPC1 Short transient receptor potential channel 1 1.698e-18 0.29

Raddeanin A

PYGM_RABIT PYGM Glycogen phosphorylase, muscle form 3.06e-68 0.49
PTN2_HUMAN PTPN2 Tyrosine-protein phosphatase non-receptor type 2 4.217e-64 0.62
SO1B2_RAT Slco1b2 Solute carrier organic anion transporter family member 1B2 4.102e-56 0.45
CD81_HUMAN CD81 CD81 antigen 2.084e-52 0.42
PTN1_HUMAN PTPN1 Tyrosine-protein phosphatase non-receptor type 1 6.032e-45 0.65
DPOLB_RAT Polb DNA polymerase beta 2.218e-42 0.54
DHI2_RAT Hsd11b2 Corticosteroid 11-beta-dehydrogenase isozyme 2 1.264e-35 0.28
PA2A1_ECHCA Acidic phospholipase A2 EC-I 5.796e-35 0.43
PA2B1_NAJME Basic phospholipase A2 1 5.796e-35 0.43
PA2BA_PROFL Basic phospholipase A2 PLA-A 5.796e-35 0.43
FGF1_HUMAN FGF1 Fibroblast growth factor 1 5.378e-25 0.30
TF_HUMAN F3 Tissue factor 2.503e-22 0.80
AMYP_HUMAN AMY2A Pancreatic alpha-amylase 8.683e-18 0.28
PTN6_HUMAN PTPN6 Tyrosine-protein phosphatase non-receptor type 6 4.91e-17 0.52
NOS2_RAT Nos2 Nitric oxide synthase, inducible 2.22e-16 0.36
AK1BA_HUMAN AKR1B10 Aldo-keto reductase family 1 member B10 9.215e-15 0.54
CAH2_BOVIN CA2 Carbonic anhydrase 2 4.94e-14 0.46
FGF2_HUMAN FGF2 Fibroblast growth factor 2 1.489e-13 0.30
DHI2_MOUSE Hsd11b2 Corticosteroid 11-beta-dehydrogenase isozyme 2 1.797e-13 0.29
Q9YQ12_9HIV1 protease Protease 2.073e-13 0.54
AT1A1_CANLF ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 4.664e-13 0.30
VEGFA_HUMAN VEGFA Vascular endothelial growth factor A 5.769e-10 0.30
MRP2_RAT Abcc2 Canalicular multispecific organic anion transporter 1 9.209e-10 0.45
EST2_HUMAN CES2 Cocaine esterase 2.819e-09 0.40
DHI2_HUMAN HSD11B2 Corticosteroid 11-beta-dehydrogenase isozyme 2 4.213e-09 0.45
PLCG1_HUMAN PLCG1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 6.094e-09 0.35
DPOLB_HUMAN POLB DNA polymerase beta 9.099e-09 0.54
PPAC_HUMAN ACP1 Low molecular weight phosphotyrosine protein phosphatase 3.985e-08 0.49
PIN1_HUMAN PIN1 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 3.137e-07 0.36
TF65_HUMAN RELA Transcription factor p65 3.284e-06 0.54
NF2L2_HUMAN NFE2L2 Nuclear factor erythroid 2-related factor 2 3.493e-06 0.36
IL2_HUMAN IL2 Interleukin-2 9.12e-06 0.30

AZD1480

TYK2_MOUSE Tyk2 Non-receptor tyrosine-protein kinase TYK2 2.735e-54 0.43
JAK1_MOUSE Jak1 Tyrosine-protein kinase JAK1 8.238e-35 0.43
PKNA_MYCTU pknA Serine/threonine-protein kinase PknA 1.751e-34 0.30
STA5B_HUMAN STAT5B Signal transducer and activator of transcription 5B 6.237e-23 0.58
JAK2_HUMAN JAK2 Tyrosine-protein kinase JAK2 5.926e-18 0.80
JAK2_MOUSE Jak2 Tyrosine-protein kinase JAK2 2.288e-17 0.43
NTRK1_HUMAN NTRK1 High affinity nerve growth factor receptor 4.408e-17 0.77
PAK4_HUMAN PAK4 Serine/threonine-protein kinase PAK 4 1.11e-16 0.36
STA5A_HUMAN STAT5A Signal transducer and activator of transcription 5A 3.331e-16 0.74
AURKA_HUMAN AURKA Aurora kinase A 1.332e-15 0.50
IGF1R_HUMAN IGF1R Insulin-like growth factor 1 receptor 3.109e-15 0.53
KCC1D_HUMAN CAMK1D Calcium/calmodulin-dependent protein kinase type 1D 1.077e-14 0.50
JAK3_MOUSE Jak3 Tyrosine-protein kinase JAK3 1.643e-14 0.43
PKNB_MYCTU pknB Serine/threonine-protein kinase PknB 5.227e-13 0.39
JAK3_HUMAN JAK3 Tyrosine-protein kinase JAK3 1.5e-12 0.80
LTK_HUMAN LTK Leukocyte tyrosine kinase receptor 4.59e-09 0.50
AURKB_HUMAN AURKB Aurora kinase B 8.577e-09 0.58
PLCG1_HUMAN PLCG1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 2.398e-08 0.33
IDHC_HUMAN IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic 5.213e-08 0.32
ACVR1_HUMAN ACVR1 Activin receptor type-1 6.566e-08 0.50
MUSK_HUMAN MUSK Muscle, skeletal receptor tyrosine-protein kinase 7.898e-08 0.45
FGFR1_HUMAN FGFR1 Fibroblast growth factor receptor 1 1.224e-07 0.53
ALK_HUMAN ALK ALK tyrosine kinase receptor 2.553e-07 0.50
GSK3A_HUMAN GSK3A Glycogen synthase kinase-3 alpha 2.61e-07 0.36
GSK3B_HUMAN GSK3B Glycogen synthase kinase-3 beta 5.7e-07 0.42
RON_HUMAN MST1R Macrophage-stimulating protein receptor 7.276e-07 0.50
PAK1_HUMAN PAK1 Serine/threonine-protein kinase PAK 1 1.961e-06 0.32
SIK1_HUMAN SIK1 Serine/threonine-protein kinase SIK1 2.414e-06 0.43
KCC2A_HUMAN CAMK2A Calcium/calmodulin-dependent protein kinase type II subunit alpha 9.446e-06 0.50

SC75741

KC1A_BOVIN CSNK1A1 Casein kinase I isoform alpha 2.452e-48 0.32
KC1D_RAT Csnk1d Casein kinase I isoform delta 1.001e-46 0.36
Q9BJF5_TOXGO CDPK1 Calmodulin-domain protein kinase 1 2.322e-44 0.44
GRM5_MOUSE Grm5 Metabotropic glutamate receptor 5 4.904e-36 0.37
RAF1_HUMAN RAF1 RAF proto-oncogene serine/threonine-protein kinase 6.77e-24 0.36
ENL_HUMAN MLLT1 Protein ENL 1.605e-23 0.29
MP2K7_HUMAN MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 2.716e-23 0.35
FTSZ_MYCTU ftsZ Cell division protein FtsZ 4.989e-23 0.28
BRAF_HUMAN BRAF Serine/threonine-protein kinase B-raf 2.964e-14 0.36
SIR3_HUMAN SIRT3 NAD-dependent protein deacetylase sirtuin-3, mitochondrial 5.54e-14 0.33
KPCI_HUMAN PRKCI Protein kinase C iota type 2.456e-13 0.33
GRB7_HUMAN GRB7 Growth factor receptor-bound protein 7 6.108e-13 0.28
CHK1_HUMAN CHEK1 Serine/threonine-protein kinase Chk1 1.001e-12 0.33
Q0GMK6_RABIT CDK4 Cyclin-dependent kinase 4 3.051e-11 0.31
COX2_SHEEP MT-CO2 Cytochrome c oxidase subunit 2 1.444e-10 0.28
PDE10_HUMAN PDE10A cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 4.956e-10 0.32
KCNJ3_RAT Kcnj3 G protein-activated inward rectifier potassium channel 1 1.238e-09 0.31
KCNJ5_RAT Kcnj5 G protein-activated inward rectifier potassium channel 4 1.238e-09 0.31
THIO_HUMAN TXN Thioredoxin 1.464e-09 0.34
SIR1_HUMAN SIRT1 NAD-dependent protein deacetylase sirtuin-1 1.868e-09 0.33
KS6A2_HUMAN RPS6KA2 Ribosomal protein S6 kinase alpha-2 2.42e-09 0.32
KLF5_HUMAN KLF5 Krueppel-like factor 5 5.537e-09 0.32
NR0B1_HUMAN NR0B1 Nuclear receptor subfamily 0 group B member 1 4.387e-08 0.28
MALT1_HUMAN MALT1 Mucosa-associated lymphoid tissue lymphoma translocation protein 1 1.635e-07 0.30
SIR2_HUMAN SIRT2 NAD-dependent protein deacetylase sirtuin-2 1.732e-07 0.33
COT2_HUMAN NR2F2 COUP transcription factor 2 1.778e-07 0.38
LIMK2_HUMAN LIMK2 LIM domain kinase 2 5.009e-07 0.32
ETHR_MYCTU ethR HTH-type transcriptional regulator EthR 6.453e-07 0.30
CPT1B_RAT Cpt1b Carnitine O-palmitoyltransferase 1, muscle isoform 1.092e-06 0.28
KC1E_HUMAN CSNK1E Casein kinase I isoform epsilon 1.247e-06 0.36
TBA1A_PIG TUBA1A Tubulin alpha-1A chain 1.436e-06 0.37
KPYK_STAAR pyk Pyruvate kinase 1.506e-06 0.30
TPOR_HUMAN MPL Thrombopoietin receptor 2.707e-06 0.29
EST1_PIG Liver carboxylesterase 3.739e-06 0.30

Tomatine

AT1A1_CANLF ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 1.404e-47 0.34
AMYP_HUMAN AMY2A Pancreatic alpha-amylase 5.625e-36 0.29
LEG4_HUMAN LGALS4 Galectin-4 2.665e-35 0.29
LEG8_HUMAN LGALS8 Galectin-8 2.665e-35 0.29
NMDE3_HUMAN GRIN2C Glutamate receptor ionotropic, NMDA 2C 3.952e-18 0.29
FGF1_HUMAN FGF1 Fibroblast growth factor 1 6.224e-18 0.32
NMDE4_HUMAN GRIN2D Glutamate receptor ionotropic, NMDA 2D 3.775e-15 0.29
TYRO_HUMAN TYR Tyrosinase 4.874e-12 0.29
ERG2_YEAST ERG2 C-8 sterol isomerase 6.368e-12 0.53
IF4A1_MOUSE Eif4a1 Eukaryotic initiation factor 4A-I 2.276e-11 0.31
IL2_HUMAN IL2 Interleukin-2 9.586e-09 0.48
EBP_HUMAN EBP 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase 4.538e-06 0.53

Prexasertib

CHK1_HUMAN CHEK1 Serine/threonine-protein kinase Chk1 3.172e-41 0.46
RAB7L_HUMAN RAB29 Ras-related protein Rab-7L1 6.045e-41 0.32
Q8WQX9_9TRYP PDEB1 Phosphodiesterase 2.475e-11 0.30
HASP_HUMAN HASPIN Serine/threonine-protein kinase haspin 3.598e-09 0.30
CLK1_MOUSE Clk1 Dual specificity protein kinase CLK1 1.36e-06 0.31
S22AC_HUMAN SLC22A12 Solute carrier family 22 member 12 1.709e-06 0.31

Saikosaponin D

SO1B2_RAT Slco1b2 Solute carrier organic anion transporter family member 1B2 1.102e-37 0.30
AMYP_HUMAN AMY2A Pancreatic alpha-amylase 1.795e-18 0.29
FGF1_HUMAN FGF1 Fibroblast growth factor 1 3.236e-17 0.30
FGF2_HUMAN FGF2 Fibroblast growth factor 2 6.017e-14 0.30
TF_HUMAN F3 Tissue factor 9.725e-12 0.42
VEGFA_HUMAN VEGFA Vascular endothelial growth factor A 2.998e-10 0.30
MRP2_RAT Abcc2 Canalicular multispecific organic anion transporter 1 9.412e-07 0.30

NCB-0846

CKX2_ARATH CKX2 Cytokinin dehydrogenase 2 5.874e-26 0.29
CDK1_HUMAN CDK1 Cyclin-dependent kinase 1 3.331e-16 0.45
AHK3_ARATH AHK3 Histidine kinase 3 2.776e-15 0.29
JUN_HUMAN JUN Transcription factor AP-1 6.328e-15 0.37
AHK4_ARATH AHK4 Histidine kinase 4 5.743e-12 0.29
KS6A2_MOUSE Rps6ka2 Ribosomal protein S6 kinase alpha-2 1.072e-09 0.28
PLK2_HUMAN PLK2 Serine/threonine-protein kinase PLK2 1.24e-09 0.32
EPHB3_HUMAN EPHB3 Ephrin type-B receptor 3 1.104e-08 0.32
IRAK1_HUMAN IRAK1 Interleukin-1 receptor-associated kinase 1 2.021e-08 0.36
QPCT_HUMAN QPCT Glutaminyl-peptide cyclotransferase 2.041e-08 0.31
MK10_HUMAN MAPK10 Mitogen-activated protein kinase 10 7.087e-08 0.37
PLCG1_HUMAN PLCG1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 2.148e-07 0.29
GALR2_HUMAN GALR2 Galanin receptor type 2 3.243e-07 0.30
EGFR_MOUSE Egfr Epidermal growth factor receptor 3.629e-07 0.29
NEK5_HUMAN NEK5 Serine/threonine-protein kinase Nek5 3.811e-07 0.29
ULK1_HUMAN ULK1 Serine/threonine-protein kinase ULK1 1.298e-06 0.41
ULK2_HUMAN ULK2 Serine/threonine-protein kinase ULK2 1.802e-06 0.41
CCNE1_HUMAN CCNE1 G1/S-specific cyclin-E1 7.268e-06 0.33
GALR1_HUMAN GALR1 Galanin receptor type 1 8.092e-06 0.30

VLX1570

TGM3L_HUMAN TGM6 Protein-glutamine gamma-glutamyltransferase 6 2e-23 0.29
TGM2_MOUSE Tgm2 Protein-glutamine gamma-glutamyltransferase 2 3.72e-18 0.29
TRY1_BOVIN Cationic trypsin 2.22e-16 0.36
GP183_HUMAN GPR183 G-protein coupled receptor 183 1.659e-10 0.33
DHI1_RAT Hsd11b1 Corticosteroid 11-beta-dehydrogenase isozyme 1 3.558e-09 0.34
DHB3_RAT Hsd17b3 Testosterone 17-beta-dehydrogenase 3 1.595e-07 0.29
COMT_RAT Comt Catechol O-methyltransferase 3.193e-07 0.43
WDR5_HUMAN WDR5 WD repeat-containing protein 5 6.306e-07 0.30

Alexidine dihydrochloride

NOS2_RAT Nos2 Nitric oxide synthase, inducible 5.338e-13 0.28
DHYS_RAT Dhps Deoxyhypusine synthase 6.519e-08 0.33