Results of Job: search_b409137d-6169-4210-bfff-3e2db6ab47d5

Query Target Key Target Name Description P-Value MaxTC

Bexagliflozin

SC5A2_HUMAN SLC5A2 Sodium/glucose cotransporter 2 0 1.00
SC5A1_HUMAN SLC5A1 Sodium/glucose cotransporter 1 8.35e-153 1.00
SC5A2_MOUSE Slc5a2 Sodium/glucose cotransporter 2 1.587e-166 0.63
SC5A4_HUMAN SLC5A4 Solute carrier family 5 member 4 5.176e-92 0.77
FIMH_ECOLI fimH Type 1 fimbrin D-mannose specific adhesin 3.22e-78 0.35
AA3R_RABIT ADORA3 Adenosine receptor A3 3.219e-67 0.30
AA1R_RABIT ADORA1 Adenosine receptor A1 8.919e-65 0.30
SC5AB_HUMAN SLC5A11 Sodium/myo-inositol cotransporter 2 4.369e-61 0.77
RASN_HUMAN NRAS GTPase NRas 1.457e-36 0.29
SC5A2_RAT Slc5a2 Sodium/glucose cotransporter 2 7.96e-36 0.77
B4EH87_BURCJ Lectin 9.967e-32 0.33
ADK_TOXGO AK Adenosine kinase 1.914e-23 0.32
PYGM_RABIT PYGM Glycogen phosphorylase, muscle form 1.44e-19 0.36
FGF1_HUMAN FGF1 Fibroblast growth factor 1 3.053e-17 0.31
FGF2_HUMAN FGF2 Fibroblast growth factor 2 5.74e-14 0.31
Q9QXI6_MOUSE Slc5a1 SGLT1 protein 1.203e-13 0.30
VEGFA_HUMAN VEGFA Vascular endothelial growth factor A 2.898e-10 0.31
S28A2_HUMAN SLC28A2 Sodium/nucleoside cotransporter 2 5.487e-10 0.30
TYRO_HUMAN TYR Tyrosinase 6.947e-10 0.32
S29A1_HUMAN SLC29A1 Equilibrative nucleoside transporter 1 4.164e-08 0.32
BIP_HUMAN HSPA5 Endoplasmic reticulum chaperone BiP 4.463e-08 0.32
LYAG_MOUSE Gaa Lysosomal alpha-glucosidase 5.175e-08 0.31
RASH_HUMAN HRAS GTPase HRas 6.744e-08 0.29
ADRB2_RAT Adrb2 Beta-2 adrenergic receptor 8.771e-08 0.30
AA1R_RAT Adora1 Adenosine receptor A1 1.048e-07 0.32
LEG9_HUMAN LGALS9 Galectin-9 1.841e-06 0.28
AA2AR_RAT Adora2a Adenosine receptor A2a 3.02e-06 0.32

Dacomitinib

EGFR_HUMAN EGFR Epidermal growth factor receptor 0 1.00
ERBB2_HUMAN ERBB2 Receptor tyrosine-protein kinase erbB-2 2.298e-286 1.00
ERBB4_HUMAN ERBB4 Receptor tyrosine-protein kinase erbB-4 1.415e-198 1.00
SRC_HUMAN SRC Proto-oncogene tyrosine-protein kinase Src 1.652e-35 1.00
LCK_HUMAN LCK Tyrosine-protein kinase Lck 7.472e-14 1.00
JAK3_HUMAN JAK3 Tyrosine-protein kinase JAK3 1.317e-13 1.00
EPHA2_HUMAN EPHA2 Ephrin type-A receptor 2 1.934e-291 0.54
EPHB4_HUMAN EPHB4 Ephrin type-B receptor 4 6.042e-235 0.57
VGFR2_HUMAN KDR Vascular endothelial growth factor receptor 2 6.302e-142 0.59
PGFRB_HUMAN PDGFRB Platelet-derived growth factor receptor beta 4.515e-99 0.62
DUS2L_HUMAN DUS2 tRNA-dihydrouridine(20) synthase [NAD(P)+]-like 1.448e-86 0.69
F16P1_PIG FBP1 Fructose-1,6-bisphosphatase 1 1.297e-66 0.57
ERBB3_HUMAN ERBB3 Receptor tyrosine-protein kinase erbB-3 1.354e-65 0.69
TBA1A_RAT Tuba1a Tubulin alpha-1A chain 3.89e-65 0.53
ERBB2_RAT Erbb2 Receptor tyrosine-protein kinase erbB-2 8.325e-60 0.38
RET_HUMAN RET Proto-oncogene tyrosine-protein kinase receptor Ret 1.79e-57 0.56
BRAF_HUMAN BRAF Serine/threonine-protein kinase B-raf 5.925e-57 0.53
VGFR1_HUMAN FLT1 Vascular endothelial growth factor receptor 1 1.316e-56 0.56
ULK3_MOUSE Ulk3 Serine/threonine-protein kinase ULK3 1.972e-52 0.53
CCR4_MOUSE Ccr4 C-C chemokine receptor type 4 1.278e-50 0.36
MELK_HUMAN MELK Maternal embryonic leucine zipper kinase 6.67e-50 0.38
MET_HUMAN MET Hepatocyte growth factor receptor 2.219e-49 0.60
STK10_HUMAN STK10 Serine/threonine-protein kinase 10 3.093e-41 0.60
MP2K5_HUMAN MAP2K5 Dual specificity mitogen-activated protein kinase kinase 5 1.738e-40 0.60
MK04_HUMAN MAPK4 Mitogen-activated protein kinase 4 2.293e-38 0.53
EPHA6_HUMAN EPHA6 Ephrin type-A receptor 6 5.916e-38 0.60
EPHB6_HUMAN EPHB6 Ephrin type-B receptor 6 3.732e-37 0.60
CTRO_HUMAN CIT Citron Rho-interacting kinase 2.111e-36 0.60
STK36_HUMAN STK36 Serine/threonine-protein kinase 36 2.609e-36 0.53
AURKA_HUMAN AURKA Aurora kinase A 3.878e-36 0.57
KMT5A_HUMAN KMT5A N-lysine methyltransferase KMT5A 1.401e-35 0.29
EPHA8_HUMAN EPHA8 Ephrin type-A receptor 8 1.141e-34 0.53
M3K4_HUMAN MAP3K4 Mitogen-activated protein kinase kinase kinase 4 2.566e-33 0.48
HNMT_RAT Hnmt Histamine N-methyltransferase 3.701e-33 0.32
PHKG1_HUMAN PHKG1 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 1.779e-32 0.60
EPHA5_HUMAN EPHA5 Ephrin type-A receptor 5 4.169e-32 0.53
EPHB1_HUMAN EPHB1 Ephrin type-B receptor 1 8.981e-32 0.53
CSK_HUMAN CSK Tyrosine-protein kinase CSK 1.452e-31 0.48
PGFRA_HUMAN PDGFRA Platelet-derived growth factor receptor alpha 2.448e-31 0.62
TXK_HUMAN TXK Tyrosine-protein kinase TXK 2.592e-31 0.60
SIK2_HUMAN SIK2 Serine/threonine-protein kinase SIK2 3.47e-31 0.53
WEE2_HUMAN WEE2 Wee1-like protein kinase 2 7.081e-31 0.48
AURKB_HUMAN AURKB Aurora kinase B 1.089e-29 0.57
VGFR3_HUMAN FLT4 Vascular endothelial growth factor receptor 3 1.44e-29 0.57
SBK1_HUMAN SBK1 Serine/threonine-protein kinase SBK1 2.834e-29 0.60
TIE2_HUMAN TEK Angiopoietin-1 receptor 1.266e-28 0.57
TIE1_HUMAN TIE1 Tyrosine-protein kinase receptor Tie-1 8.933e-28 0.48
STK35_HUMAN STK35 Serine/threonine-protein kinase 35 2.154e-27 0.38
M4K3_HUMAN MAP4K3 Mitogen-activated protein kinase kinase kinase kinase 3 3.798e-27 0.48
COQ8B_HUMAN COQ8B Atypical kinase COQ8B, mitochondrial 4.483e-27 0.48
ENL_HUMAN MLLT1 Protein ENL 5.245e-27 0.33
RIPK2_HUMAN RIPK2 Receptor-interacting serine/threonine-protein kinase 2 7.801e-27 0.60
M4K1_HUMAN MAP4K1 Mitogen-activated protein kinase kinase kinase kinase 1 3.84e-26 0.48
MK06_HUMAN MAPK6 Mitogen-activated protein kinase 6 1.197e-25 0.53
M3K3_HUMAN MAP3K3 Mitogen-activated protein kinase kinase kinase 3 1.285e-25 0.53
M3K8_HUMAN MAP3K8 Mitogen-activated protein kinase kinase kinase 8 2.008e-25 0.35
M3K19_HUMAN MAP3K19 Mitogen-activated protein kinase kinase kinase 19 2.1e-25 0.53
DMPK_HUMAN DMPK Myotonin-protein kinase 2.575e-25 0.53
EPHA3_HUMAN EPHA3 Ephrin type-A receptor 3 3.565e-25 0.53
PDE5A_BOVIN PDE5A cGMP-specific 3',5'-cyclic phosphodiesterase 4.586e-25 0.37
RAF1_HUMAN RAF1 RAF proto-oncogene serine/threonine-protein kinase 5.817e-25 0.48
STK4_HUMAN STK4 Serine/threonine-protein kinase 4 6.947e-25 0.48
GAK_HUMAN GAK Cyclin-G-associated kinase 7.295e-25 0.60
ABL2_HUMAN ABL2 Tyrosine-protein kinase ABL2 7.31e-25 0.53
CSF1R_HUMAN CSF1R Macrophage colony-stimulating factor 1 receptor 7.871e-25 0.48
MYLK2_HUMAN MYLK2 Myosin light chain kinase 2, skeletal/cardiac muscle 1.042e-24 0.53
AUKBA_XENLA aurkb-a Aurora kinase B-A 1.569e-24 0.39
ST32B_HUMAN STK32B Serine/threonine-protein kinase 32B 2.58e-24 0.48
MRCKG_HUMAN CDC42BPG Serine/threonine-protein kinase MRCK gamma 5.654e-24 0.38
E2AK3_HUMAN EIF2AK3 Eukaryotic translation initiation factor 2-alpha kinase 3 6.131e-24 0.45
MALT1_HUMAN MALT1 Mucosa-associated lymphoid tissue lymphoma translocation protein 1 1.528e-23 0.34
STK25_HUMAN STK25 Serine/threonine-protein kinase 25 1.802e-23 0.48
M3K2_HUMAN MAP3K2 Mitogen-activated protein kinase kinase kinase 2 3.86e-23 0.53
FGR_HUMAN FGR Tyrosine-protein kinase Fgr 4.761e-23 0.53
STK24_HUMAN STK24 Serine/threonine-protein kinase 24 6.553e-23 0.48
ENV_HV1Y2 env Envelope glycoprotein gp160 1.014e-22 0.31
LRRK2_HUMAN LRRK2 Leucine-rich repeat serine/threonine-protein kinase 2 4.97e-22 0.38
CDK16_HUMAN CDK16 Cyclin-dependent kinase 16 7.671e-22 0.48
EPHA1_HUMAN EPHA1 Ephrin type-A receptor 1 9.007e-22 0.53
NUAK2_HUMAN NUAK2 NUAK family SNF1-like kinase 2 1.055e-21 0.53
STK3_MOUSE Stk3 Serine/threonine-protein kinase 3 1.98e-21 0.48
EPHB2_HUMAN EPHB2 Ephrin type-B receptor 2 9.738e-21 0.43
HUNK_HUMAN HUNK Hormonally up-regulated neu tumor-associated kinase 1.004e-20 0.38
ULK3_HUMAN ULK3 Serine/threonine-protein kinase ULK3 1.127e-20 0.38
KIT_HUMAN KIT Mast/stem cell growth factor receptor Kit 1.641e-20 0.58
C3SLB7_ECOLX glmU Bifunctional protein GlmU 3.004e-20 0.38
INSR_HUMAN INSR Insulin receptor 6.959e-20 0.60
SMN_HUMAN SMN1; SMN2 Survival motor neuron protein 7.617e-20 0.29
RIPK4_HUMAN RIPK4 Receptor-interacting serine/threonine-protein kinase 4 1.683e-19 0.38
DCLK3_HUMAN DCLK3 Serine/threonine-protein kinase DCLK3 3.223e-19 0.53
ETHR_MYCS2 ethR HTH-type transcriptional regulator EthR 3.251e-19 0.31
STK33_HUMAN STK33 Serine/threonine-protein kinase 33 3.917e-19 0.48
PMYT1_HUMAN PKMYT1 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase 4.695e-19 0.48
EPHA7_HUMAN EPHA7 Ephrin type-A receptor 7 6.237e-19 0.38
SPTC2_HUMAN SPTLC2 Serine palmitoyltransferase 2 6.741e-19 0.30
PDE6A_BOVIN PDE6A Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha 7.376e-19 0.29
FGFR1_HUMAN FGFR1 Fibroblast growth factor receptor 1 1.112e-18 0.56
KC1AL_HUMAN CSNK1A1L Casein kinase I isoform alpha-like 2.173e-18 0.48
TNI3K_HUMAN TNNI3K Serine/threonine-protein kinase TNNI3K 2.595e-18 0.48
COQ8A_HUMAN COQ8A Atypical kinase COQ8A, mitochondrial 3.013e-18 0.38
ASF1A_HUMAN ASF1A Histone chaperone ASF1A 3.244e-18 0.29
FLT3_HUMAN FLT3 Receptor-type tyrosine-protein kinase FLT3 3.826e-18 0.62
SIK1_HUMAN SIK1 Serine/threonine-protein kinase SIK1 4.287e-18 0.38
CCR1_MOUSE Ccr1 C-C chemokine receptor type 1 4.303e-18 0.31
RON_HUMAN MST1R Macrophage-stimulating protein receptor 7.172e-18 0.56
IRAK3_HUMAN IRAK3 Interleukin-1 receptor-associated kinase 3 1.881e-17 0.53
DUSTY_HUMAN DSTYK Dual serine/threonine and tyrosine protein kinase 2.479e-17 0.38
KS6A6_HUMAN RPS6KA6 Ribosomal protein S6 kinase alpha-6 3.1e-17 0.60
FGFR4_HUMAN FGFR4 Fibroblast growth factor receptor 4 3.81e-17 0.38
5HT4R_RAT Htr4 5-hydroxytryptamine receptor 4 1.11e-16 0.38
FYN_HUMAN FYN Tyrosine-protein kinase Fyn 1.11e-16 0.48
LUCI_RENRE Coelenterazine h 2-monooxygenase 1.11e-16 0.32
M3K13_HUMAN MAP3K13 Mitogen-activated protein kinase kinase kinase 13 1.11e-16 0.38
MAST1_HUMAN MAST1 Microtubule-associated serine/threonine-protein kinase 1 1.11e-16 0.38
UFO_HUMAN AXL Tyrosine-protein kinase receptor UFO 1.11e-16 0.60
MCHR1_HUMAN MCHR1 Melanin-concentrating hormone receptor 1 2.22e-16 0.35
ST17B_HUMAN STK17B Serine/threonine-protein kinase 17B 3.331e-16 0.53
MRCKB_HUMAN CDC42BPB Serine/threonine-protein kinase MRCK beta 4.441e-16 0.38
ST32A_HUMAN STK32A Serine/threonine-protein kinase 32A 4.441e-16 0.38
CD38_MOUSE Cd38 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 7.772e-16 0.40
CCR4_HUMAN CCR4 C-C chemokine receptor type 4 1.221e-15 0.39
TNIK_HUMAN TNIK TRAF2 and NCK-interacting protein kinase 1.887e-15 0.53
SIK3_HUMAN SIK3 Serine/threonine-protein kinase SIK3 2.442e-15 0.38
BMP2K_HUMAN BMP2K BMP-2-inducible protein kinase 3.886e-15 0.48
BLK_MOUSE Blk Tyrosine-protein kinase Blk 4.441e-15 0.29
MYO3A_HUMAN MYO3A Myosin-IIIa 1.077e-14 0.29
E2AK4_HUMAN EIF2AK4 eIF-2-alpha kinase GCN2 1.155e-14 0.48
CPT2_RAT Cpt2 Carnitine O-palmitoyltransferase 2, mitochondrial 1.41e-14 0.30
NLK_HUMAN NLK Serine/threonine-protein kinase NLK 2.986e-14 0.53
FGFR2_HUMAN FGFR2 Fibroblast growth factor receptor 2 3.353e-14 0.45
YES_HUMAN YES1 Tyrosine-protein kinase Yes 3.797e-14 0.48
ALK_HUMAN ALK ALK tyrosine kinase receptor 5.496e-14 0.48
MYO3B_HUMAN MYO3B Myosin-IIIb 5.618e-14 0.29
NEK3_HUMAN NEK3 Serine/threonine-protein kinase Nek3 5.618e-14 0.38
CD38_HUMAN CD38 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 6.384e-14 0.40
ST38L_HUMAN STK38L Serine/threonine-protein kinase 38-like 7.028e-14 0.48
EHMT2_HUMAN EHMT2 Histone-lysine N-methyltransferase EHMT2 8.56e-14 0.31
MP2K2_HUMAN MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 1.407e-13 0.48
ABCG2_HUMAN ABCG2 Broad substrate specificity ATP-binding cassette transporter ABCG2 1.541e-13 0.53
PHKG2_HUMAN PHKG2 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 1.594e-13 0.60
LYN_HUMAN LYN Tyrosine-protein kinase Lyn 2.658e-13 0.53
SLK_HUMAN SLK STE20-like serine/threonine-protein kinase 2.681e-13 0.60
PDE3B_HUMAN PDE3B cGMP-inhibited 3',5'-cyclic phosphodiesterase B 3.495e-13 0.32
BLK_HUMAN BLK Tyrosine-protein kinase Blk 3.806e-13 0.60
VRK2_HUMAN VRK2 Serine/threonine-protein kinase VRK2 3.922e-13 0.29
ABL1_MOUSE Abl1 Tyrosine-protein kinase ABL1 4.392e-13 0.30
RET4_HUMAN RBP4 Retinol-binding protein 4 4.821e-13 0.33
O77823_PIG PDE4A Cyclic AMP-specific phosphodiesterase SSPDE4A1A 5.118e-13 0.31
HDAC3_HUMAN HDAC3 Histone deacetylase 3 8.227e-13 0.39
FA11_HUMAN F11 Coagulation factor XI 8.763e-13 0.30
INSRR_HUMAN INSRR Insulin receptor-related protein 9.3e-13 0.38
MP2K1_HUMAN MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 1.052e-12 0.48
EPHA4_HUMAN EPHA4 Ephrin type-A receptor 4 1.311e-12 0.38
STK26_HUMAN STK26 Serine/threonine-protein kinase 26 1.463e-12 0.38
KKCC1_HUMAN CAMKK1 Calcium/calmodulin-dependent protein kinase kinase 1 1.544e-12 0.48
AAK1_HUMAN AAK1 AP2-associated protein kinase 1 2.566e-12 0.48
TESK1_HUMAN TESK1 Dual specificity testis-specific protein kinase 1 2.659e-12 0.38
CDK15_HUMAN CDK15 Cyclin-dependent kinase 15 2.774e-12 0.29
TAOK2_HUMAN TAOK2 Serine/threonine-protein kinase TAO2 4.405e-12 0.30
F16P1_HUMAN FBP1 Fructose-1,6-bisphosphatase 1 4.685e-12 0.57
P2RX3_HUMAN P2RX3 P2X purinoceptor 3 4.856e-12 0.31
DDR1_HUMAN DDR1 Epithelial discoidin domain-containing receptor 1 5.27e-12 0.38
PDE3A_HUMAN PDE3A cGMP-inhibited 3',5'-cyclic phosphodiesterase A 6.644e-12 0.32
IGF1R_HUMAN IGF1R Insulin-like growth factor 1 receptor 8.034e-12 0.60
FRK_HUMAN FRK Tyrosine-protein kinase FRK 8.713e-12 0.60
AURKC_HUMAN AURKC Aurora kinase C 1.602e-11 0.38
CLK1_MOUSE Clk1 Dual specificity protein kinase CLK1 3.126e-11 0.35
CDKL2_HUMAN CDKL2 Cyclin-dependent kinase-like 2 6.81e-11 0.35
HDAC6_HUMAN HDAC6 Histone deacetylase 6 7.734e-11 0.43
MKNK1_HUMAN MKNK1 MAP kinase-interacting serine/threonine-protein kinase 1 8.364e-11 0.60
LTK_HUMAN LTK Leukocyte tyrosine kinase receptor 9.763e-11 0.53
CDK14_HUMAN CDK14 Cyclin-dependent kinase 14 1.066e-10 0.29
CCNA1_HUMAN CCNA1 Cyclin-A1 1.207e-10 0.35
DYR1A_HUMAN DYRK1A Dual specificity tyrosine-phosphorylation-regulated kinase 1A 1.211e-10 0.60
E2AK1_HUMAN EIF2AK1 Eukaryotic translation initiation factor 2-alpha kinase 1 1.218e-10 0.30
PDE11_HUMAN PDE11A Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A 1.27e-10 0.31
CPT2_HUMAN CPT2 Carnitine O-palmitoyltransferase 2, mitochondrial 2.135e-10 0.30
DDR2_HUMAN DDR2 Discoidin domain-containing receptor 2 2.208e-10 0.38
M3K9_HUMAN MAP3K9 Mitogen-activated protein kinase kinase kinase 9 3.187e-10 0.38
KKCC2_HUMAN CAMKK2 Calcium/calmodulin-dependent protein kinase kinase 2 3.49e-10 0.48
KCC1D_HUMAN CAMK1D Calcium/calmodulin-dependent protein kinase type 1D 3.596e-10 0.48
SRPK3_HUMAN SRPK3 SRSF protein kinase 3 3.862e-10 0.34
ANKK1_HUMAN ANKK1 Ankyrin repeat and protein kinase domain-containing protein 1 4.352e-10 0.29
MEP2_YEAST MEP2 Ammonium transporter MEP2 5.866e-10 0.29
MERTK_HUMAN MERTK Tyrosine-protein kinase Mer 5.999e-10 0.48
PI42C_HUMAN PIP4K2C Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma 6.204e-10 0.53
GRK4_HUMAN GRK4 G protein-coupled receptor kinase 4 6.75e-10 0.34
CDKL3_HUMAN CDKL3 Cyclin-dependent kinase-like 3 6.847e-10 0.29
NEK11_HUMAN NEK11 Serine/threonine-protein kinase Nek11 7.541e-10 0.29
CPT1A_HUMAN CPT1A Carnitine O-palmitoyltransferase 1, liver isoform 8.155e-10 0.31
MKNK2_HUMAN MKNK2 MAP kinase-interacting serine/threonine-protein kinase 2 8.158e-10 0.60
HIPK4_HUMAN HIPK4 Homeodomain-interacting protein kinase 4 8.327e-10 0.60
HDAC1_HUMAN HDAC1 Histone deacetylase 1 1.021e-09 0.43
CLK3_HUMAN CLK3 Dual specificity protein kinase CLK3 1.066e-09 0.48
FES_HUMAN FES Tyrosine-protein kinase Fes/Fps 1.293e-09 0.48
KC1E_HUMAN CSNK1E Casein kinase I isoform epsilon 1.336e-09 0.60
BMX_HUMAN BMX Cytoplasmic tyrosine-protein kinase BMX 1.46e-09 0.48
ABL1_HUMAN ABL1 Tyrosine-protein kinase ABL1 1.509e-09 0.62
M4K5_HUMAN MAP4K5 Mitogen-activated protein kinase kinase kinase kinase 5 1.558e-09 0.53
HCK_HUMAN HCK Tyrosine-protein kinase HCK 1.69e-09 0.60
KLKB1_HUMAN KLKB1 Plasma kallikrein 1.71e-09 0.30
TNK1_HUMAN TNK1 Non-receptor tyrosine-protein kinase TNK1 1.79e-09 0.34
CPT1B_HUMAN CPT1B Carnitine O-palmitoyltransferase 1, muscle isoform 2.18e-09 0.30
CPT1A_RAT Cpt1a Carnitine O-palmitoyltransferase 1, liver isoform 2.551e-09 0.31
DYR1B_HUMAN DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B 2.83e-09 0.60
T23O_HUMAN TDO2 Tryptophan 2,3-dioxygenase 3.065e-09 0.32
MAK_HUMAN MAK Serine/threonine-protein kinase MAK 3.29e-09 0.29
KS6A4_HUMAN RPS6KA4 Ribosomal protein S6 kinase alpha-4 4.429e-09 0.53
PI42B_HUMAN PIP4K2B Phosphatidylinositol 5-phosphate 4-kinase type-2 beta 4.712e-09 0.48
CSK21_HUMAN CSNK2A1 Casein kinase II subunit alpha 5.093e-09 0.38
SRC_CHICK SRC Proto-oncogene tyrosine-protein kinase Src 5.561e-09 0.38
IRAK1_HUMAN IRAK1 Interleukin-1 receptor-associated kinase 1 5.744e-09 0.60
DLDH_MYCTU lpdC Dihydrolipoyl dehydrogenase 6.356e-09 0.33
KS6B1_HUMAN RPS6KB1 Ribosomal protein S6 kinase beta-1 6.515e-09 0.38
ACES_ANOGA Ace Acetylcholinesterase 6.816e-09 0.33
PAK2_HUMAN PAK2 Serine/threonine-protein kinase PAK 2 7.006e-09 0.38
M3K11_HUMAN MAP3K11 Mitogen-activated protein kinase kinase kinase 11 8.455e-09 0.38
F16P1_RAT Fbp1 Fructose-1,6-bisphosphatase 1 9.682e-09 0.31
FER_HUMAN FER Tyrosine-protein kinase Fer 1.17e-08 0.48
PTK6_HUMAN PTK6 Protein-tyrosine kinase 6 1.348e-08 0.53
GRM4_RAT Grm4 Metabotropic glutamate receptor 4 1.361e-08 0.30
MARK1_HUMAN MARK1 Serine/threonine-protein kinase MARK1 1.53e-08 0.48
PAK3_HUMAN PAK3 Serine/threonine-protein kinase PAK 3 1.633e-08 0.29
ST17A_HUMAN STK17A Serine/threonine-protein kinase 17A 3.391e-08 0.60
EPHB3_HUMAN EPHB3 Ephrin type-B receptor 3 3.575e-08 0.29
NEK9_HUMAN NEK9 Serine/threonine-protein kinase Nek9 3.684e-08 0.29
TLK2_HUMAN TLK2 Serine/threonine-protein kinase tousled-like 2 3.985e-08 0.29
SRMS_HUMAN SRMS Tyrosine-protein kinase Srms 4.967e-08 0.38
PAK6_HUMAN PAK6 Serine/threonine-protein kinase PAK 6 7.687e-08 0.38
NUAK1_HUMAN NUAK1 NUAK family SNF1-like kinase 1 8.455e-08 0.38
CDKL5_HUMAN CDKL5 Cyclin-dependent kinase-like 5 9.573e-08 0.29
HIPK3_HUMAN HIPK3 Homeodomain-interacting protein kinase 3 1.004e-07 0.29
CSKP_HUMAN CASK Peripheral plasma membrane protein CASK 1.031e-07 0.29
STK39_HUMAN STK39 STE20/SPS1-related proline-alanine-rich protein kinase 1.031e-07 0.29
GALR2_HUMAN GALR2 Galanin receptor type 2 1.065e-07 0.35
KCNJ6_HUMAN KCNJ6 G protein-activated inward rectifier potassium channel 2 1.511e-07 0.30
CLK1_HUMAN CLK1 Dual specificity protein kinase CLK1 1.695e-07 0.57
TEC_HUMAN TEC Tyrosine-protein kinase Tec 1.846e-07 0.29
M3K10_HUMAN MAP3K10 Mitogen-activated protein kinase kinase kinase 10 2.172e-07 0.38
CD11A_HUMAN CDK11A Cyclin-dependent kinase 11A 2.201e-07 0.29
CDK13_HUMAN CDK13 Cyclin-dependent kinase 13 2.201e-07 0.29
M3K20_HUMAN MAP3K20 Mitogen-activated protein kinase kinase kinase 20 2.413e-07 0.48
ACVR1_HUMAN ACVR1 Activin receptor type-1 2.516e-07 0.38
ENPP1_HUMAN ENPP1 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 2.666e-07 0.30
WNT3A_MOUSE Wnt3a Protein Wnt-3a 2.824e-07 0.28
CCRL2_HUMAN CCRL2 C-C chemokine receptor-like 2 4.001e-07 0.30
TLK1_HUMAN TLK1 Serine/threonine-protein kinase tousled-like 1 4.905e-07 0.29
HIPK1_HUMAN HIPK1 Homeodomain-interacting protein kinase 1 5.366e-07 0.29
MINK1_HUMAN MINK1 Misshapen-like kinase 1 5.399e-07 0.53
KPCD2_HUMAN PRKD2 Serine/threonine-protein kinase D2 5.891e-07 0.53
PLK1_HUMAN PLK1 Serine/threonine-protein kinase PLK1 6.556e-07 0.41
E2AK2_HUMAN EIF2AK2 Interferon-induced, double-stranded RNA-activated protein kinase 8.056e-07 0.48
M3K1_HUMAN MAP3K1 Mitogen-activated protein kinase kinase kinase 1 9.396e-07 0.29
NIM1_HUMAN NIM1K Serine/threonine-protein kinase NIM1 9.396e-07 0.29
ARAF_HUMAN ARAF Serine/threonine-protein kinase A-Raf 1.032e-06 0.33
CLTR1_CAVPO CYSLTR1 Cysteinyl leukotriene receptor 1 1.036e-06 0.32
P3C2G_HUMAN PIK3C2G Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma 1.036e-06 0.31
SL9A1_RAT Slc9a1 Sodium/hydrogen exchanger 1 1.105e-06 0.29
TYRO3_HUMAN TYRO3 Tyrosine-protein kinase receptor TYRO3 1.12e-06 0.48
SCN9A_HUMAN SCN9A Sodium channel protein type 9 subunit alpha 1.438e-06 0.35
CD11B_HUMAN CDK11B Cyclin-dependent kinase 11B 1.583e-06 0.29
KCNJ5_HUMAN KCNJ5 G protein-activated inward rectifier potassium channel 4 1.667e-06 0.30
CDK2_HUMAN CDK2 Cyclin-dependent kinase 2 1.672e-06 0.41
BRAF_MOUSE Braf Serine/threonine-protein kinase B-raf 1.783e-06 0.34
LDHA_HUMAN LDHA L-lactate dehydrogenase A chain 2.352e-06 0.30
GRM4_HUMAN GRM4 Metabotropic glutamate receptor 4 2.496e-06 0.30
NCOA1_HUMAN NCOA1 Nuclear receptor coactivator 1 2.656e-06 0.30
CDK18_HUMAN CDK18 Cyclin-dependent kinase 18 2.686e-06 0.29
PYGL_HUMAN PYGL Glycogen phosphorylase, liver form 3.355e-06 0.33
TF7L2_HUMAN TCF7L2 Transcription factor 7-like 2 3.447e-06 0.31
FGFR3_HUMAN FGFR3 Fibroblast growth factor receptor 3 3.611e-06 0.38
TAOK3_HUMAN TAOK3 Serine/threonine-protein kinase TAO3 3.81e-06 0.38
KCNJ3_HUMAN KCNJ3 G protein-activated inward rectifier potassium channel 1 4.697e-06 0.30
AGP1_YEAST AGP1 General amino acid permease AGP1 6.166e-06 0.29
MYLK3_HUMAN MYLK3 Myosin light chain kinase 3 6.733e-06 0.29
CDK7_HUMAN CDK7 Cyclin-dependent kinase 7 7.401e-06 0.53
DYRK2_HUMAN DYRK2 Dual specificity tyrosine-phosphorylation-regulated kinase 2 8.366e-06 0.60
TERT_HUMAN TERT Telomerase reverse transcriptase 9.887e-06 0.31

Erdafitinib

FGFR2_HUMAN FGFR2 Fibroblast growth factor receptor 2 0 1.00
FGFR3_HUMAN FGFR3 Fibroblast growth factor receptor 3 0 1.00
FGFR4_HUMAN FGFR4 Fibroblast growth factor receptor 4 0 1.00
FGFR1_HUMAN FGFR1 Fibroblast growth factor receptor 1 4.143e-311 1.00
VGFR2_HUMAN KDR Vascular endothelial growth factor receptor 2 8.11e-129 1.00
FLT3_HUMAN FLT3 Receptor-type tyrosine-protein kinase FLT3 1.799e-91 0.90
TPX2_HUMAN TPX2 Targeting protein for Xklp2 7.752e-47 0.30
TTK_HUMAN TTK Dual specificity protein kinase TTK 3.396e-23 0.38
MET_HUMAN MET Hepatocyte growth factor receptor 4.441e-16 0.37
F263_HUMAN PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 3.614e-13 0.37
INCE_HUMAN INCENP Inner centromere protein 2.955e-09 0.30
PDE3B_HUMAN PDE3B cGMP-inhibited 3',5'-cyclic phosphodiesterase B 2.619e-07 0.34
RON_HUMAN MST1R Macrophage-stimulating protein receptor 5.444e-07 0.32
YES_HUMAN YES1 Tyrosine-protein kinase Yes 2.752e-06 0.32
CSF1R_HUMAN CSF1R Macrophage colony-stimulating factor 1 receptor 4.081e-06 0.38
PDE1A_HUMAN PDE1A Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 5.273e-06 0.31

Ribociclib

CDK4_HUMAN CDK4 Cyclin-dependent kinase 4 0 1.00
CDK6_HUMAN CDK6 Cyclin-dependent kinase 6 2.484e-317 1.00
CCND3_HUMAN CCND3 G1/S-specific cyclin-D3 9.832e-190 1.00
CCNT1_HUMAN CCNT1 Cyclin-T1 1.516e-24 1.00
CDK9_HUMAN CDK9 Cyclin-dependent kinase 9 1.121e-14 1.00
CCND1_HUMAN CCND1 G1/S-specific cyclin-D1 1.347e-213 0.74
CCND2_HUMAN CCND2 G1/S-specific cyclin-D2 3.818e-179 0.61
CCNB1_HUMAN CCNB1 G2/mitotic-specific cyclin-B1 6.931e-74 0.58
CCNA2_HUMAN CCNA2 Cyclin-A2 1.017e-56 0.71
CDK1_HUMAN CDK1 Cyclin-dependent kinase 1 4.236e-54 0.79
CCNH_HUMAN CCNH Cyclin-H 7.077e-52 0.46
CDK2_HUMAN CDK2 Cyclin-dependent kinase 2 7.045e-48 0.95
CCNE2_HUMAN CCNE2 G1/S-specific cyclin-E2 4.022e-45 0.53
CCNA1_HUMAN CCNA1 Cyclin-A1 1.474e-30 0.53
ALK_HUMAN ALK ALK tyrosine kinase receptor 2.912e-30 0.61
CCNB2_HUMAN CCNB2 G2/mitotic-specific cyclin-B2 2.815e-27 0.47
CCNB3_HUMAN CCNB3 G2/mitotic-specific cyclin-B3 2.815e-27 0.47
CDK7_HUMAN CDK7 Cyclin-dependent kinase 7 3.552e-26 0.46
STAT6_HUMAN STAT6 Signal transducer and activator of transcription 6 9.431e-21 0.36
MK07_HUMAN MAPK7 Mitogen-activated protein kinase 7 1.17e-19 0.35
KPCD1_HUMAN PRKD1 Serine/threonine-protein kinase D1 8.882e-16 0.33
FLT3_HUMAN FLT3 Receptor-type tyrosine-protein kinase FLT3 1.332e-15 0.61
CCNE1_HUMAN CCNE1 G1/S-specific cyclin-E1 2.232e-14 0.61
AURKA_HUMAN AURKA Aurora kinase A 4.13e-14 0.53
TTK_HUMAN TTK Dual specificity protein kinase TTK 4.26e-13 0.44
MARK4_HUMAN MARK4 MAP/microtubule affinity-regulating kinase 4 8.145e-13 0.41
MK09_HUMAN MAPK9 Mitogen-activated protein kinase 9 1.006e-11 0.61
PMYT1_HUMAN PKMYT1 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase 3.238e-11 0.31
PLK1_HUMAN PLK1 Serine/threonine-protein kinase PLK1 5.387e-11 0.44
AURKB_HUMAN AURKB Aurora kinase B 5.749e-11 0.53
MK10_HUMAN MAPK10 Mitogen-activated protein kinase 10 1.099e-10 0.34
BRDT_HUMAN BRDT Bromodomain testis-specific protein 1.318e-09 0.32
INSR_HUMAN INSR Insulin receptor 1.573e-09 0.37
TRPV4_HUMAN TRPV4 Transient receptor potential cation channel subfamily V member 4 5.292e-09 0.32
MK08_HUMAN MAPK8 Mitogen-activated protein kinase 8 1.406e-08 0.61
KKCC2_HUMAN CAMKK2 Calcium/calmodulin-dependent protein kinase kinase 2 2.697e-08 0.53
ZAP70_HUMAN ZAP70 Tyrosine-protein kinase ZAP-70 3.472e-08 0.32
KPCD2_HUMAN PRKD2 Serine/threonine-protein kinase D2 5.098e-08 0.33
TAOK2_HUMAN TAOK2 Serine/threonine-protein kinase TAO2 1.232e-07 0.53
CSF1R_HUMAN CSF1R Macrophage colony-stimulating factor 1 receptor 4.109e-07 0.43
EZH1_HUMAN EZH1 Histone-lysine N-methyltransferase EZH1 8.227e-07 0.29
NEK6_HUMAN NEK6 Serine/threonine-protein kinase Nek6 2.184e-06 0.30
IGF1R_HUMAN IGF1R Insulin-like growth factor 1 receptor 5.653e-06 0.37

Brigatinib

ALK_HUMAN ALK ALK tyrosine kinase receptor 3.451e-221 1.00
INSR_HUMAN INSR Insulin receptor 1.678e-206 1.00
IGF1R_HUMAN IGF1R Insulin-like growth factor 1 receptor 1.203e-184 1.00
EGFR_HUMAN EGFR Epidermal growth factor receptor 3.232e-72 1.00
ROS1_HUMAN ROS1 Proto-oncogene tyrosine-protein kinase ROS 1.375e-33 1.00
FLT3_HUMAN FLT3 Receptor-type tyrosine-protein kinase FLT3 3.968e-11 1.00
FAK1_HUMAN PTK2 Focal adhesion kinase 1 9.743e-167 0.74
FAK2_HUMAN PTK2B Protein-tyrosine kinase 2-beta 1.06e-109 0.74
TTK_HUMAN TTK Dual specificity protein kinase TTK 1.91e-101 0.74
MK07_HUMAN MAPK7 Mitogen-activated protein kinase 7 7.321e-101 0.74
INSR_RAT Insr Insulin receptor 8.508e-92 0.74
LRRK2_HUMAN LRRK2 Leucine-rich repeat serine/threonine-protein kinase 2 1.164e-88 0.74
CCR4_MOUSE Ccr4 C-C chemokine receptor type 4 1.538e-59 0.34
ERBB2_HUMAN ERBB2 Receptor tyrosine-protein kinase erbB-2 3.193e-59 0.74
ABL1_MOUSE Abl1 Tyrosine-protein kinase ABL1 8.042e-54 0.53
PLK1_HUMAN PLK1 Serine/threonine-protein kinase PLK1 1.564e-51 0.74
CCND2_HUMAN CCND2 G1/S-specific cyclin-D2 3.49e-48 0.34
ST32C_HUMAN STK32C Serine/threonine-protein kinase 32C 3.497e-45 0.74
ETV6_HUMAN ETV6 Transcription factor ETV6 1.389e-44 0.35
NEK3_HUMAN NEK3 Serine/threonine-protein kinase Nek3 9.378e-40 0.74
ZAP70_HUMAN ZAP70 Tyrosine-protein kinase ZAP-70 1.315e-39 0.74
M3K7_HUMAN MAP3K7 Mitogen-activated protein kinase kinase kinase 7 1.278e-35 0.74
SNRK_HUMAN SNRK SNF-related serine/threonine-protein kinase 1.426e-32 0.74
NEK6_HUMAN NEK6 Serine/threonine-protein kinase Nek6 2.03e-31 0.74
HUNK_HUMAN HUNK Hormonally up-regulated neu tumor-associated kinase 1.867e-30 0.74
DCLK2_HUMAN DCLK2 Serine/threonine-protein kinase DCLK2 1.918e-29 0.74
ALK_MOUSE Alk ALK tyrosine kinase receptor 5.385e-29 0.74
M3K6_HUMAN MAP3K6 Mitogen-activated protein kinase kinase kinase 6 5.385e-29 0.74
MYO3A_HUMAN MYO3A Myosin-IIIa 3.749e-28 0.74
DCLK1_HUMAN DCLK1 Serine/threonine-protein kinase DCLK1 3.81e-28 0.74
KS6A6_HUMAN RPS6KA6 Ribosomal protein S6 kinase alpha-6 6.461e-28 0.74
PAK1_HUMAN PAK1 Serine/threonine-protein kinase PAK 1 1.518e-27 0.74
MYO3B_HUMAN MYO3B Myosin-IIIb 9.457e-27 0.74
KCC4_HUMAN CAMK4 Calcium/calmodulin-dependent protein kinase type IV 5.918e-26 0.74
OXSR1_HUMAN OXSR1 Serine/threonine-protein kinase OSR1 5.918e-26 0.74
COQ8A_HUMAN COQ8A Atypical kinase COQ8A, mitochondrial 1.148e-25 0.74
NEK7_HUMAN NEK7 Serine/threonine-protein kinase Nek7 1.623e-25 0.74
CSF1R_HUMAN CSF1R Macrophage colony-stimulating factor 1 receptor 1.981e-25 0.74
LCK_HUMAN LCK Tyrosine-protein kinase Lck 2.444e-25 0.74
CDK4_HUMAN CDK4 Cyclin-dependent kinase 4 5.639e-25 0.74
TSSK1_HUMAN TSSK1B Testis-specific serine/threonine-protein kinase 1 6.506e-25 0.74
NIM1_HUMAN NIM1K Serine/threonine-protein kinase NIM1 2.03e-24 0.74
MRCKB_HUMAN CDC42BPB Serine/threonine-protein kinase MRCK beta 2.163e-24 0.74
MRCKG_HUMAN CDC42BPG Serine/threonine-protein kinase MRCK gamma 2.163e-24 0.74
ST32A_HUMAN STK32A Serine/threonine-protein kinase 32A 2.163e-24 0.74
PMYT1_HUMAN PKMYT1 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase 2.639e-23 0.40
COQ8B_HUMAN COQ8B Atypical kinase COQ8B, mitochondrial 2.871e-23 0.74
SIK3_HUMAN SIK3 Serine/threonine-protein kinase SIK3 2.871e-23 0.74
EHMT2_HUMAN EHMT2 Histone-lysine N-methyltransferase EHMT2 3.016e-23 0.31
BRDT_HUMAN BRDT Bromodomain testis-specific protein 1.428e-22 0.39
M3K15_HUMAN MAP3K15 Mitogen-activated protein kinase kinase kinase 15 2.078e-22 0.74
STK38_HUMAN STK38 Serine/threonine-protein kinase 38 2.078e-22 0.74
TNK1_HUMAN TNK1 Non-receptor tyrosine-protein kinase TNK1 3.028e-22 0.74
CCND1_HUMAN CCND1 G1/S-specific cyclin-D1 4.896e-22 0.37
ACK1_HUMAN TNK2 Activated CDC42 kinase 1 1.608e-21 0.74
EPHB3_HUMAN EPHB3 Ephrin type-B receptor 3 1.649e-21 0.74
TSSK2_HUMAN TSSK2 Testis-specific serine/threonine-protein kinase 2 1.737e-21 0.74
MARK4_HUMAN MARK4 MAP/microtubule affinity-regulating kinase 4 2.554e-21 0.74
SIK2_HUMAN SIK2 Serine/threonine-protein kinase SIK2 4.157e-21 0.74
AVR2A_HUMAN ACVR2A Activin receptor type-2A 5.803e-21 0.74
KAPCB_HUMAN PRKACB cAMP-dependent protein kinase catalytic subunit beta 5.803e-21 0.74
ST32B_HUMAN STK32B Serine/threonine-protein kinase 32B 5.803e-21 0.74
ST38L_HUMAN STK38L Serine/threonine-protein kinase 38-like 5.803e-21 0.74
PLK3_HUMAN PLK3 Serine/threonine-protein kinase PLK3 8.729e-21 0.74
GRK7_HUMAN GRK7 Rhodopsin kinase GRK7 3.691e-20 0.74
MK10_HUMAN MAPK10 Mitogen-activated protein kinase 10 5.103e-20 0.74
PLK2_HUMAN PLK2 Serine/threonine-protein kinase PLK2 7.045e-20 0.74
RIPK4_HUMAN RIPK4 Receptor-interacting serine/threonine-protein kinase 4 7.738e-20 0.74
NEK9_HUMAN NEK9 Serine/threonine-protein kinase Nek9 9.756e-20 0.74
KKCC2_HUMAN CAMKK2 Calcium/calmodulin-dependent protein kinase kinase 2 1.022e-19 0.74
INSRR_HUMAN INSRR Insulin receptor-related protein 2.205e-19 0.74
DAPK2_HUMAN DAPK2 Death-associated protein kinase 2 2.537e-19 0.74
UFO_HUMAN AXL Tyrosine-protein kinase receptor UFO 3.43e-19 0.74
PHKG1_HUMAN PHKG1 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 3.474e-19 0.74
M3K4_HUMAN MAP3K4 Mitogen-activated protein kinase kinase kinase 4 3.602e-19 0.74
STK16_HUMAN STK16 Serine/threonine-protein kinase 16 6.17e-19 0.74
DUSTY_HUMAN DSTYK Dual serine/threonine and tyrosine protein kinase 9.181e-19 0.74
CCND3_HUMAN CCND3 G1/S-specific cyclin-D3 1.082e-18 0.34
CSKP_HUMAN CASK Peripheral plasma membrane protein CASK 1.107e-18 0.74
MAST1_HUMAN MAST1 Microtubule-associated serine/threonine-protein kinase 1 1.107e-18 0.74
STK39_HUMAN STK39 STE20/SPS1-related proline-alanine-rich protein kinase 1.107e-18 0.74
DAPK1_HUMAN DAPK1 Death-associated protein kinase 1 1.435e-18 0.74
STK33_HUMAN STK33 Serine/threonine-protein kinase 33 2.554e-18 0.74
HIPK3_HUMAN HIPK3 Homeodomain-interacting protein kinase 3 3.205e-18 0.74
SRC_HUMAN SRC Proto-oncogene tyrosine-protein kinase Src 3.517e-18 0.74
KKCC1_HUMAN CAMKK1 Calcium/calmodulin-dependent protein kinase kinase 1 4.058e-18 0.74
RIOK3_HUMAN RIOK3 Serine/threonine-protein kinase RIO3 4.058e-18 0.74
M3K10_HUMAN MAP3K10 Mitogen-activated protein kinase kinase kinase 10 6.533e-18 0.74
KC1AL_HUMAN CSNK1A1L Casein kinase I isoform alpha-like 9.186e-18 0.74
DMPK_HUMAN DMPK Myotonin-protein kinase 1.176e-17 0.74
MET_HUMAN MET Hepatocyte growth factor receptor 1.467e-17 0.74
MK09_HUMAN MAPK9 Mitogen-activated protein kinase 9 1.772e-17 0.74
DYR1B_HUMAN DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B 1.783e-17 0.74
STK35_HUMAN STK35 Serine/threonine-protein kinase 35 1.796e-17 0.74
MK08_HUMAN MAPK8 Mitogen-activated protein kinase 8 2.656e-17 0.74
GAK_HUMAN GAK Cyclin-G-associated kinase 2.996e-17 0.74
JAK3_HUMAN JAK3 Tyrosine-protein kinase JAK3 1.11e-16 0.74
LTK_HUMAN LTK Leukocyte tyrosine kinase receptor 1.11e-16 0.74
LYAM3_HUMAN SELP P-selectin 1.11e-16 0.33
SBK3_HUMAN SBK3 Uncharacterized serine/threonine-protein kinase SBK3 1.11e-16 0.74
ULK3_HUMAN ULK3 Serine/threonine-protein kinase ULK3 1.11e-16 0.74
HIPK1_HUMAN HIPK1 Homeodomain-interacting protein kinase 1 2.22e-16 0.74
M3K1_HUMAN MAP3K1 Mitogen-activated protein kinase kinase kinase 1 3.331e-16 0.74
PRP4B_HUMAN PRPF4B Serine/threonine-protein kinase PRP4 homolog 3.331e-16 0.74
SRMS_HUMAN SRMS Tyrosine-protein kinase Srms 3.331e-16 0.74
TXK_HUMAN TXK Tyrosine-protein kinase TXK 3.331e-16 0.74
ERBB4_HUMAN ERBB4 Receptor tyrosine-protein kinase erbB-4 4.441e-16 0.74
NUAK1_HUMAN NUAK1 NUAK family SNF1-like kinase 1 4.441e-16 0.74
CDK2_HUMAN CDK2 Cyclin-dependent kinase 2 5.551e-16 0.74
GRK1_HUMAN GRK1 Rhodopsin kinase GRK1 6.661e-16 0.74
FGFR1_HUMAN FGFR1 Fibroblast growth factor receptor 1 1.11e-15 0.74
CDK15_HUMAN CDK15 Cyclin-dependent kinase 15 1.332e-15 0.74
LATS1_HUMAN LATS1 Serine/threonine-protein kinase LATS1 1.332e-15 0.74
FES_HUMAN FES Tyrosine-protein kinase Fes/Fps 1.443e-15 0.74
IGF1R_MOUSE Igf1r Insulin-like growth factor 1 receptor 1.776e-15 0.32
M3K19_HUMAN MAP3K19 Mitogen-activated protein kinase kinase kinase 19 1.776e-15 0.74
MP2K3_HUMAN MAP2K3 Dual specificity mitogen-activated protein kinase kinase 3 3.553e-15 0.74
FGFR4_HUMAN FGFR4 Fibroblast growth factor receptor 4 4.552e-15 0.74
AVR2B_HUMAN ACVR2B Activin receptor type-2B 5.218e-15 0.74
CCR4_HUMAN CCR4 C-C chemokine receptor type 4 5.218e-15 0.34
EPHA7_HUMAN EPHA7 Ephrin type-A receptor 7 5.218e-15 0.74
KCC1G_HUMAN CAMK1G Calcium/calmodulin-dependent protein kinase type 1G 5.218e-15 0.74
SBK1_HUMAN SBK1 Serine/threonine-protein kinase SBK1 5.218e-15 0.74
STK24_HUMAN STK24 Serine/threonine-protein kinase 24 5.218e-15 0.74
EPHA2_HUMAN EPHA2 Ephrin type-A receptor 2 5.329e-15 0.74
MP2K4_HUMAN MAP2K4 Dual specificity mitogen-activated protein kinase kinase 4 7.661e-15 0.74
PAK3_HUMAN PAK3 Serine/threonine-protein kinase PAK 3 8.993e-15 0.74
EPHA5_HUMAN EPHA5 Ephrin type-A receptor 5 1.121e-14 0.74
BKRB1_MACFA BDKRB1 B1 bradykinin receptor 1.221e-14 0.29
KCC2D_HUMAN CAMK2D Calcium/calmodulin-dependent protein kinase type II subunit delta 1.288e-14 0.74
BRSK2_HUMAN BRSK2 Serine/threonine-protein kinase BRSK2 1.765e-14 0.74
PAK6_HUMAN PAK6 Serine/threonine-protein kinase PAK 6 1.765e-14 0.74
FER_HUMAN FER Tyrosine-protein kinase Fer 1.887e-14 0.74
WEE1_HUMAN WEE1 Wee1-like protein kinase 2.842e-14 0.74
PHKG2_HUMAN PHKG2 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 3.497e-14 0.74
CCNE2_HUMAN CCNE2 G1/S-specific cyclin-E2 3.575e-14 0.34
STK10_HUMAN STK10 Serine/threonine-protein kinase 10 3.73e-14 0.74
SIK1_HUMAN SIK1 Serine/threonine-protein kinase SIK1 4.485e-14 0.74
MP2K1_HUMAN MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 5.34e-14 0.74
CILK1_HUMAN CILK1 Serine/threonine-protein kinase ICK 5.351e-14 0.74
NEK4_HUMAN NEK4 Serine/threonine-protein kinase Nek4 5.906e-14 0.74
CDK6_HUMAN CDK6 Cyclin-dependent kinase 6 8.804e-14 0.34
LATS2_HUMAN LATS2 Serine/threonine-protein kinase LATS2 1.481e-13 0.74
MP2K6_HUMAN MAP2K6 Dual specificity mitogen-activated protein kinase kinase 6 1.481e-13 0.74
EPHA4_HUMAN EPHA4 Ephrin type-A receptor 4 1.564e-13 0.74
M4K3_HUMAN MAP4K3 Mitogen-activated protein kinase kinase kinase kinase 3 1.564e-13 0.74
ERBB3_HUMAN ERBB3 Receptor tyrosine-protein kinase erbB-3 1.799e-13 0.39
PAK2_HUMAN PAK2 Serine/threonine-protein kinase PAK 2 2.297e-13 0.74
MP2K2_HUMAN MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 2.567e-13 0.74
PKN1_HUMAN PKN1 Serine/threonine-protein kinase N1 2.6e-13 0.74
KS6A1_HUMAN RPS6KA1 Ribosomal protein S6 kinase alpha-1 2.743e-13 0.74
BMR1A_HUMAN BMPR1A Bone morphogenetic protein receptor type-1A 3.78e-13 0.74
CDK17_HUMAN CDK17 Cyclin-dependent kinase 17 3.78e-13 0.74
M3K13_HUMAN MAP3K13 Mitogen-activated protein kinase kinase kinase 13 3.78e-13 0.74
TIE2_HUMAN TEK Angiopoietin-1 receptor 4.337e-13 0.74
M4K1_HUMAN MAP4K1 Mitogen-activated protein kinase kinase kinase kinase 1 4.847e-13 0.74
KCC1D_HUMAN CAMK1D Calcium/calmodulin-dependent protein kinase type 1D 4.946e-13 0.74
WEE2_HUMAN WEE2 Wee1-like protein kinase 2 4.998e-13 0.30
CCNA2_HUMAN CCNA2 Cyclin-A2 5.23e-13 0.34
EPHA1_HUMAN EPHA1 Ephrin type-A receptor 1 8.206e-13 0.74
EPHB1_HUMAN EPHB1 Ephrin type-B receptor 1 8.206e-13 0.74
KCC2A_HUMAN CAMK2A Calcium/calmodulin-dependent protein kinase type II subunit alpha 8.236e-13 0.74
ANKK1_HUMAN ANKK1 Ankyrin repeat and protein kinase domain-containing protein 1 8.993e-13 0.74
MARK1_HUMAN MARK1 Serine/threonine-protein kinase MARK1 8.993e-13 0.74
PAK5_HUMAN PAK5 Serine/threonine-protein kinase PAK 5 8.993e-13 0.74
PI51A_HUMAN PIP5K1A Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha 8.993e-13 0.74
PGFRB_MOUSE Pdgfrb Platelet-derived growth factor receptor beta 1.007e-12 0.37
KPCD3_HUMAN PRKD3 Serine/threonine-protein kinase D3 1.328e-12 0.74
EPHA6_HUMAN EPHA6 Ephrin type-A receptor 6 1.357e-12 0.74
TYRO3_HUMAN TYRO3 Tyrosine-protein kinase receptor TYRO3 1.421e-12 0.74
AAK1_HUMAN AAK1 AP2-associated protein kinase 1 1.534e-12 0.74
CDPK1_PLAF7 CPK1 Calcium-dependent protein kinase 1 2.01e-12 0.74
MUSK_HUMAN MUSK Muscle, skeletal receptor tyrosine-protein kinase 2.01e-12 0.74
STK25_HUMAN STK25 Serine/threonine-protein kinase 25 2.01e-12 0.74
BMR1B_HUMAN BMPR1B Bone morphogenetic protein receptor type-1B 2.196e-12 0.74
EPHB2_HUMAN EPHB2 Ephrin type-B receptor 2 2.196e-12 0.74
DAPK3_HUMAN DAPK3 Death-associated protein kinase 3 2.239e-12 0.74
SRC_CHICK SRC Proto-oncogene tyrosine-protein kinase Src 2.766e-12 0.37
AURKA_HUMAN AURKA Aurora kinase A 3.027e-12 0.80
KCC1A_HUMAN CAMK1 Calcium/calmodulin-dependent protein kinase type 1 3.112e-12 0.74
STK36_HUMAN STK36 Serine/threonine-protein kinase 36 4.25e-12 0.74
TIE1_HUMAN TIE1 Tyrosine-protein kinase receptor Tie-1 5.417e-12 0.74
SRC_RAT Src Proto-oncogene tyrosine-protein kinase Src 6.542e-12 0.29
BMPR2_HUMAN BMPR2 Bone morphogenetic protein receptor type-2 8.552e-12 0.74
SRPK3_HUMAN SRPK3 SRSF protein kinase 3 8.552e-12 0.74
RON_HUMAN MST1R Macrophage-stimulating protein receptor 1.158e-11 0.74
KS6A4_HUMAN RPS6KA4 Ribosomal protein S6 kinase alpha-4 1.493e-11 0.74
STAT6_HUMAN STAT6 Signal transducer and activator of transcription 6 1.595e-11 0.33
FYN_HUMAN FYN Tyrosine-protein kinase Fyn 1.597e-11 0.74
GRK4_HUMAN GRK4 G protein-coupled receptor kinase 4 1.646e-11 0.74
EPHB6_HUMAN EPHB6 Ephrin type-B receptor 6 1.842e-11 0.74
PTK6_HUMAN PTK6 Protein-tyrosine kinase 6 2.906e-11 0.74
DCLK3_HUMAN DCLK3 Serine/threonine-protein kinase DCLK3 3.044e-11 0.74
IRAK3_HUMAN IRAK3 Interleukin-1 receptor-associated kinase 3 3.044e-11 0.74
MK15_HUMAN MAPK15 Mitogen-activated protein kinase 15 3.044e-11 0.74
ULK1_HUMAN ULK1 Serine/threonine-protein kinase ULK1 3.044e-11 0.74
MATK_HUMAN MATK Megakaryocyte-associated tyrosine-protein kinase 3.323e-11 0.74
STK4_HUMAN STK4 Serine/threonine-protein kinase 4 5.428e-11 0.74
ULK2_HUMAN ULK2 Serine/threonine-protein kinase ULK2 5.428e-11 0.74
FGR_HUMAN FGR Tyrosine-protein kinase Fgr 5.653e-11 0.74
SRPK1_HUMAN SRPK1 SRSF protein kinase 1 8.823e-11 0.74
TAOK1_HUMAN TAOK1 Serine/threonine-protein kinase TAO1 9.137e-11 0.74
HIPK4_HUMAN HIPK4 Homeodomain-interacting protein kinase 4 9.194e-11 0.74
M3K3_HUMAN MAP3K3 Mitogen-activated protein kinase kinase kinase 3 9.368e-11 0.74
MP2K5_HUMAN MAP2K5 Dual specificity mitogen-activated protein kinase kinase 5 1.067e-10 0.74
NEK2_HUMAN NEK2 Serine/threonine-protein kinase Nek2 1.115e-10 0.74
CDK7_HUMAN CDK7 Cyclin-dependent kinase 7 1.298e-10 0.74
MYLK_HUMAN MYLK Myosin light chain kinase, smooth muscle 1.338e-10 0.74
EPHB4_HUMAN EPHB4 Ephrin type-B receptor 4 1.828e-10 0.74
O77823_PIG PDE4A Cyclic AMP-specific phosphodiesterase SSPDE4A1A 2.134e-10 0.31
CSK_HUMAN CSK Tyrosine-protein kinase CSK 2.401e-10 0.74
RET_HUMAN RET Proto-oncogene tyrosine-protein kinase receptor Ret 2.461e-10 0.74
BMP2K_HUMAN BMP2K BMP-2-inducible protein kinase 2.556e-10 0.74
TAOK2_HUMAN TAOK2 Serine/threonine-protein kinase TAO2 2.556e-10 0.74
EPHA3_HUMAN EPHA3 Ephrin type-A receptor 3 2.668e-10 0.74
MINK1_HUMAN MINK1 Misshapen-like kinase 1 2.922e-10 0.74
MRCKA_HUMAN CDC42BPA Serine/threonine-protein kinase MRCK alpha 2.934e-10 0.74
NTRK2_HUMAN NTRK2 BDNF/NT-3 growth factors receptor 3.078e-10 0.74
PDE6A_BOVIN PDE6A Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha 3.339e-10 0.31
ABL2_HUMAN ABL2 Tyrosine-protein kinase ABL2 3.553e-10 0.74
EHMT1_HUMAN EHMT1 Histone-lysine N-methyltransferase EHMT1 4.596e-10 0.29
FGFR3_HUMAN FGFR3 Fibroblast growth factor receptor 3 4.644e-10 0.74
CLK2_HUMAN CLK2 Dual specificity protein kinase CLK2 5.888e-10 0.74
NUAK2_HUMAN NUAK2 NUAK family SNF1-like kinase 2 6.307e-10 0.74
CLK3_HUMAN CLK3 Dual specificity protein kinase CLK3 9.042e-10 0.74
M3K2_HUMAN MAP3K2 Mitogen-activated protein kinase kinase kinase 2 9.586e-10 0.74
STK26_HUMAN STK26 Serine/threonine-protein kinase 26 9.586e-10 0.74
ACVR1_HUMAN ACVR1 Activin receptor type-1 1.044e-09 0.74
PI42C_HUMAN PIP4K2C Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma 1.124e-09 0.74
PAK4_HUMAN PAK4 Serine/threonine-protein kinase PAK 4 1.175e-09 0.74
PDE7B_HUMAN PDE7B cAMP-specific 3',5'-cyclic phosphodiesterase 7B 1.211e-09 0.31
KCC2G_HUMAN CAMK2G Calcium/calmodulin-dependent protein kinase type II subunit gamma 1.312e-09 0.74
HIPK2_HUMAN HIPK2 Homeodomain-interacting protein kinase 2 1.395e-09 0.74
BRSK1_HUMAN BRSK1 Serine/threonine-protein kinase BRSK1 1.396e-09 0.74
VGFR3_HUMAN FLT4 Vascular endothelial growth factor receptor 3 1.459e-09 0.74
AAPK1_HUMAN PRKAA1 5'-AMP-activated protein kinase catalytic subunit alpha-1 1.662e-09 0.74
M3K9_HUMAN MAP3K9 Mitogen-activated protein kinase kinase kinase 9 1.748e-09 0.74
M4K5_HUMAN MAP4K5 Mitogen-activated protein kinase kinase kinase kinase 5 1.876e-09 0.74
VGFR2_HUMAN KDR Vascular endothelial growth factor receptor 2 1.921e-09 0.74
CDK16_HUMAN CDK16 Cyclin-dependent kinase 16 2.091e-09 0.74
TEC_HUMAN TEC Tyrosine-protein kinase Tec 2.091e-09 0.74
CSK22_HUMAN CSNK2A2 Casein kinase II subunit alpha' 2.394e-09 0.74
ACV1B_HUMAN ACVR1B Activin receptor type-1B 3.008e-09 0.74
BLK_HUMAN BLK Tyrosine-protein kinase Blk 4.313e-09 0.74
PLK4_HUMAN PLK4 Serine/threonine-protein kinase PLK4 4.637e-09 0.74
CTRO_HUMAN CIT Citron Rho-interacting kinase 5.271e-09 0.39
VGFR1_HUMAN FLT1 Vascular endothelial growth factor receptor 1 5.619e-09 0.74
EBP_CAVPO EBP 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase 6.92e-09 0.29
TAOK3_HUMAN TAOK3 Serine/threonine-protein kinase TAO3 8.052e-09 0.74
JAK2_HUMAN JAK2 Tyrosine-protein kinase JAK2 9.036e-09 0.74
KPCG_HUMAN PRKCG Protein kinase C gamma type 9.08e-09 0.57
KS6A3_HUMAN RPS6KA3 Ribosomal protein S6 kinase alpha-3 1.198e-08 0.74
MK06_HUMAN MAPK6 Mitogen-activated protein kinase 6 1.201e-08 0.29
TBA1A_RAT Tuba1a Tubulin alpha-1A chain 1.201e-08 0.29
KHK_HUMAN KHK Ketohexokinase 1.407e-08 0.36
KCC2B_HUMAN CAMK2B Calcium/calmodulin-dependent protein kinase type II subunit beta 1.467e-08 0.74
FRK_HUMAN FRK Tyrosine-protein kinase FRK 1.494e-08 0.74
HCK_HUMAN HCK Tyrosine-protein kinase HCK 1.496e-08 0.74
IRAK1_HUMAN IRAK1 Interleukin-1 receptor-associated kinase 1 1.529e-08 0.74
KPCD2_HUMAN PRKD2 Serine/threonine-protein kinase D2 1.566e-08 0.74
RIPK2_HUMAN RIPK2 Receptor-interacting serine/threonine-protein kinase 2 1.58e-08 0.74
M4K4_HUMAN MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4 1.588e-08 0.74
SYK_HUMAN KARS1 Lysine--tRNA ligase 1.775e-08 0.74
PGFRA_HUMAN PDGFRA Platelet-derived growth factor receptor alpha 2.441e-08 0.74
KCNH2_HUMAN KCNH2 Potassium voltage-gated channel subfamily H member 2 2.456e-08 0.48
MERTK_HUMAN MERTK Tyrosine-protein kinase Mer 2.8e-08 0.74
AURKB_HUMAN AURKB Aurora kinase B 3.268e-08 0.74
MK12_HUMAN MAPK12 Mitogen-activated protein kinase 12 3.791e-08 0.74
PGFRB_HUMAN PDGFRB Platelet-derived growth factor receptor beta 5.045e-08 0.74
CCNB2_HUMAN CCNB2 G2/mitotic-specific cyclin-B2 5.235e-08 0.34
CCNB3_HUMAN CCNB3 G2/mitotic-specific cyclin-B3 5.235e-08 0.34
SLK_HUMAN SLK STE20-like serine/threonine-protein kinase 5.497e-08 0.74
PRKX_HUMAN PRKX cAMP-dependent protein kinase catalytic subunit PRKX 5.807e-08 0.74
KPCD1_HUMAN PRKD1 Serine/threonine-protein kinase D1 5.922e-08 0.74
FGFR2_HUMAN FGFR2 Fibroblast growth factor receptor 2 9.138e-08 0.74
O97467_PLAFA ht1 Hexose transporter 1 1.109e-07 0.48
O61059_LEIME LmGT2 Glucose transporter 1.255e-07 0.48
E2AK4_HUMAN EIF2AK4 eIF-2-alpha kinase GCN2 1.377e-07 0.74
CDK19_HUMAN CDK19 Cyclin-dependent kinase 19 1.865e-07 0.36
M4K2_HUMAN MAP4K2 Mitogen-activated protein kinase kinase kinase kinase 2 2.283e-07 0.74
AURKC_HUMAN AURKC Aurora kinase C 2.508e-07 0.74
MELK_HUMAN MELK Maternal embryonic leucine zipper kinase 2.561e-07 0.74
DYRK4_HUMAN DYRK4 Dual specificity tyrosine-phosphorylation-regulated kinase 4 2.665e-07 0.57
KC1A_HUMAN CSNK1A1 Casein kinase I isoform alpha 3.588e-07 0.40
KGP1_HUMAN PRKG1 cGMP-dependent protein kinase 1 3.796e-07 0.74
MARK3_HUMAN MARK3 MAP/microtubule affinity-regulating kinase 3 4.251e-07 0.74
PDE7A_HUMAN PDE7A High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A 4.769e-07 0.31
CHK2_HUMAN CHEK2 Serine/threonine-protein kinase Chk2 4.882e-07 0.74
ACVL1_HUMAN ACVRL1 Serine/threonine-protein kinase receptor R3 6.116e-07 0.74
M3K11_HUMAN MAP3K11 Mitogen-activated protein kinase kinase kinase 11 6.153e-07 0.74
KAPCA_HUMAN PRKACA cAMP-dependent protein kinase catalytic subunit alpha 7.28e-07 0.74
GRK5_HUMAN GRK5 G protein-coupled receptor kinase 5 7.401e-07 0.74
PKN2_HUMAN PKN2 Serine/threonine-protein kinase N2 8.13e-07 0.74
GRM4_RAT Grm4 Metabotropic glutamate receptor 4 9.109e-07 0.29
CSK21_HUMAN CSNK2A1 Casein kinase II subunit alpha 9.226e-07 0.57
CLK4_HUMAN CLK4 Dual specificity protein kinase CLK4 9.804e-07 0.74
TNIK_HUMAN TNIK TRAF2 and NCK-interacting protein kinase 9.806e-07 0.74
RIOK1_HUMAN RIOK1 Serine/threonine-protein kinase RIO1 9.945e-07 0.39
LIMK1_HUMAN LIMK1 LIM domain kinase 1 1.069e-06 0.74
E2AK3_HUMAN EIF2AK3 Eukaryotic translation initiation factor 2-alpha kinase 3 1.23e-06 0.34
ST17A_HUMAN STK17A Serine/threonine-protein kinase 17A 1.46e-06 0.74
LYN_HUMAN LYN Tyrosine-protein kinase Lyn 1.733e-06 0.74
GTR1_HUMAN SLC2A1 Solute carrier family 2, facilitated glucose transporter member 1 1.874e-06 0.48
BRAF_HUMAN BRAF Serine/threonine-protein kinase B-raf 2.236e-06 0.39
KIT_HUMAN KIT Mast/stem cell growth factor receptor Kit 2.324e-06 0.74
ABL1_HUMAN ABL1 Tyrosine-protein kinase ABL1 2.549e-06 0.74
DYR1A_HUMAN DYRK1A Dual specificity tyrosine-phosphorylation-regulated kinase 1A 2.554e-06 0.74
PKNB_MYCTU pknB Serine/threonine-protein kinase PknB 3.022e-06 0.74
BRD4_HUMAN BRD4 Bromodomain-containing protein 4 3.356e-06 0.39
TGFR2_HUMAN TGFBR2 TGF-beta receptor type-2 3.423e-06 0.74
BTK_HUMAN BTK Tyrosine-protein kinase BTK 5.543e-06 0.74
NEMO_HUMAN IKBKG NF-kappa-B essential modulator 6.707e-06 0.29
AAPK2_HUMAN PRKAA2 5'-AMP-activated protein kinase catalytic subunit alpha-2 6.84e-06 0.74
STK3_HUMAN STK3 Serine/threonine-protein kinase 3 8.858e-06 0.74
TESK1_HUMAN TESK1 Dual specificity testis-specific protein kinase 1 9.991e-06 0.29

Elagolix

GNRHR_HUMAN GNRHR Gonadotropin-releasing hormone receptor 1.507e-171 1.00
GNRHR_MACMU GNRHR Gonadotropin-releasing hormone receptor 4.503e-106 1.00
GNRHR_RAT Gnrhr Gonadotropin-releasing hormone receptor 2.989e-21 1.00
PPGB_HUMAN CTSA Lysosomal protective protein 1.11e-16 0.34
PD2R2_MOUSE Ptgdr2 Prostaglandin D2 receptor 2 1.359e-06 0.29

Ertugliflozin

SC5A2_HUMAN SLC5A2 Sodium/glucose cotransporter 2 2.448e-159 1.00
SC5A4_HUMAN SLC5A4 Solute carrier family 5 member 4 1.353e-84 1.00
SC5A1_HUMAN SLC5A1 Sodium/glucose cotransporter 1 6.85e-72 1.00
SC5A2_RAT Slc5a2 Sodium/glucose cotransporter 2 1.077e-36 1.00
SC5A2_MOUSE Slc5a2 Sodium/glucose cotransporter 2 9.233e-172 0.79
Q9QXI6_MOUSE Slc5a1 SGLT1 protein 2.576e-109 0.76
SC5AB_HUMAN SLC5A11 Sodium/myo-inositol cotransporter 2 2.536e-38 0.48
Q9RMS5_PSEAI phzR LuxR family transcriptional regulator 1.106e-07 0.30

Brexanolone

G6PD_HUMAN G6PD Glucose-6-phosphate 1-dehydrogenase 1.395e-153 1.00
GBRD_HUMAN GABRD Gamma-aminobutyric acid receptor subunit delta 8.268e-99 1.00
GBRB2_HUMAN GABRB2 Gamma-aminobutyric acid receptor subunit beta-2 3.695e-47 1.00
GBRA4_HUMAN GABRA4 Gamma-aminobutyric acid receptor subunit alpha-4 1.009e-39 1.00
GABR1_RAT Gabbr1 Gamma-aminobutyric acid type B receptor subunit 1 1.189e-26 1.00
GBRA1_HUMAN GABRA1 Gamma-aminobutyric acid receptor subunit alpha-1 1.573e-19 1.00
GBRG2_HUMAN GABRG2 Gamma-aminobutyric acid receptor subunit gamma-2 1.11e-16 1.00
GBRB3_HUMAN GABRB3 Gamma-aminobutyric acid receptor subunit beta-3 7.345e-10 1.00
CP2C9_HUMAN CYP2C9 Cytochrome P450 2C9 0.4382 1.00
S5A2_HUMAN SRD5A2 3-oxo-5-alpha-steroid 4-dehydrogenase 2 1.263e-150 0.53
S5A1_HUMAN SRD5A1 3-oxo-5-alpha-steroid 4-dehydrogenase 1 6.428e-96 0.38
AT1A1_CANLF ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 1.02e-84 0.45
GBRA4_RAT Gabra4 Gamma-aminobutyric acid receptor subunit alpha-4 7.419e-84 0.53
AT12A_HUMAN ATP12A Potassium-transporting ATPase alpha chain 2 4.729e-83 0.44
SIA4B_RAT St3gal2 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 1.755e-76 0.40
CBG_HUMAN SERPINA6 Corticosteroid-binding globulin 1.053e-74 0.68
ANDR_RAT Ar Androgen receptor 2.757e-64 0.68
SHBG_HUMAN SHBG Sex hormone-binding globulin 4.355e-62 0.68
EPHA2_MOUSE Epha2 Ephrin type-A receptor 2 7.225e-62 0.48
SMT1_ARATH SMT1 Cycloartenol-C-24-methyltransferase 2.33e-58 0.48
NR1I3_MOUSE Nr1i3 Nuclear receptor subfamily 1 group I member 3 1.441e-54 0.55
GPBAR_HUMAN GPBAR1 G-protein coupled bile acid receptor 1 3.805e-54 0.68
Q9GRG7_9TRYP g6pd Glucose-6-phosphate 1-dehydrogenase 6.734e-47 0.59
IF4A1_MOUSE Eif4a1 Eukaryotic initiation factor 4A-I 4.906e-36 0.37
CP11A_BOVIN CYP11A1 Cholesterol side-chain cleavage enzyme, mitochondrial 1.377e-35 0.28
SHBG_RAT Shbg Sex hormone-binding globulin 2.259e-35 0.44
DHC24_HUMAN DHCR24 Delta(24)-sterol reductase 3.139e-35 0.29
MRP4_HUMAN ABCC4 Multidrug resistance-associated protein 4 2.938e-34 0.38
CAH4_BOVIN CA4 Carbonic anhydrase 4 2.088e-31 0.43
GBRG1_RAT Gabrg1 Gamma-aminobutyric acid receptor subunit gamma-1 6.164e-31 0.48
3BHS1_HUMAN HSD3B1 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 7.165e-30 0.32
NMDE3_HUMAN GRIN2C Glutamate receptor ionotropic, NMDA 2C 5.863e-27 0.43
CD4_HUMAN CD4 T-cell surface glycoprotein CD4 2.847e-23 0.29
SO4C1_HUMAN SLCO4C1 Solute carrier organic anion transporter family member 4C1 8.182e-23 0.37
DHB3_HUMAN HSD17B3 Testosterone 17-beta-dehydrogenase 3 1.777e-22 0.59
NMDE4_HUMAN GRIN2D Glutamate receptor ionotropic, NMDA 2D 1.81e-22 0.43
S22A3_RAT Slc22a3 Solute carrier family 22 member 3 6.61e-22 0.35
SIA4A_HUMAN ST3GAL1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 1.223e-20 0.40
S22A2_RAT Slc22a2 Solute carrier family 22 member 2 1.012e-19 0.47
NTCP2_HUMAN SLC10A2 Ileal sodium/bile acid cotransporter 2.403e-19 0.47
NTCP_RAT Slc10a1 Sodium/bile acid cotransporter 9.803e-19 0.30
CP17A_HUMAN CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase 1.013e-18 0.51
NMDE2_HUMAN GRIN2B Glutamate receptor ionotropic, NMDA 2B 3.549e-18 0.51
NMDZ1_HUMAN GRIN1 Glutamate receptor ionotropic, NMDA 1 3.921e-18 0.51
ADCYA_HUMAN ADCY10 Adenylate cyclase type 10 6.375e-18 0.28
Q95MF8_PIG Sulfotransferase 6.785e-18 0.28
NR1H4_HUMAN NR1H4 Bile acid receptor 1.11e-16 0.56
SO1A1_RAT Slco1a1 Solute carrier organic anion transporter family member 1A1 4.441e-16 0.38
ERG2_YEAST ERG2 C-8 sterol isomerase 7.772e-16 0.47
NTCP_HUMAN SLC10A1 Sodium/bile acid cotransporter 7.772e-16 0.39
REST_BORBU resT Telomere resolvase ResT 2.554e-15 0.38
FABPL_RAT Fabp1 Fatty acid-binding protein, liver 1.255e-14 0.47
Q690N0_BOVIN PGR Progesterone receptor 1.787e-14 0.47
ABCBB_HUMAN ABCB11 Bile salt export pump 2.398e-14 0.35
DHB3_RAT Hsd17b3 Testosterone 17-beta-dehydrogenase 3 2.642e-14 0.59
S5A1_RAT Srd5a1 3-oxo-5-alpha-steroid 4-dehydrogenase 1 3.741e-14 0.35
ANDR_MOUSE Ar Androgen receptor 3.382e-13 0.47
DHI2_HUMAN HSD11B2 Corticosteroid 11-beta-dehydrogenase isozyme 2 1.059e-11 0.37
CAH2_HUMAN CA2 Carbonic anhydrase 2 2.413e-11 0.43
CAH1_HUMAN CA1 Carbonic anhydrase 1 3.221e-11 0.43
DPOLB_RAT Polb DNA polymerase beta 3.879e-11 0.56
SHH_MOUSE Shh Sonic hedgehog protein 7.641e-11 0.34
UD2B7_HUMAN UGT2B7 UDP-glucuronosyltransferase 2B7 2.73e-10 0.29
LICH_HUMAN LIPA Lysosomal acid lipase/cholesteryl ester hydrolase 2.824e-10 0.37
S22A3_HUMAN SLC22A3 Solute carrier family 22 member 3 7.132e-10 0.47
ANDR_HUMAN AR Androgen receptor 1.135e-09 0.47
PRGR_RABIT PGR Progesterone receptor 1.356e-09 0.47
FGF1_HUMAN FGF1 Fibroblast growth factor 1 3.304e-09 0.31
ECR_DROME EcR Ecdysone receptor 3.451e-09 0.32
ESR2_HUMAN ESR2 Estrogen receptor beta 1.865e-08 0.35
NPCL1_HUMAN NPC1L1 NPC1-like intracellular cholesterol transporter 1 5.985e-08 0.34
CP19A_HUMAN CYP19A1 Aromatase 7.083e-08 0.44
S5A2_RAT Srd5a2 3-oxo-5-alpha-steroid 4-dehydrogenase 2 3.006e-07 0.35
MCR_RAT Nr3c2 Mineralocorticoid receptor 3.722e-07 0.44
S22A1_HUMAN SLC22A1 Solute carrier family 22 member 1 5.466e-07 0.47
TAT_HV112 tat Protein Tat 1.522e-06 0.29
CP17A_RAT Cyp17a1 Steroid 17-alpha-hydroxylase/17,20 lyase 1.655e-06 0.31
NR1I3_HUMAN NR1I3 Nuclear receptor subfamily 1 group I member 3 2.315e-06 0.59
ESR1_HUMAN ESR1 Estrogen receptor 4.058e-06 0.35
S22A2_HUMAN SLC22A2 Solute carrier family 22 member 2 6.206e-06 0.34
EPHA7_HUMAN EPHA7 Ephrin type-A receptor 7 6.861e-06 0.37
EPHA5_HUMAN EPHA5 Ephrin type-A receptor 5 9.071e-06 0.37
ACES_TETCF ache Acetylcholinesterase 9.205e-06 0.41

Duvelisib

PK3CD_HUMAN PIK3CD Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 1.301e-148 1.00
P85A_HUMAN PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha 5.362e-130 1.00
PK3CG_HUMAN PIK3CG Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 4.762e-86 1.00
PK3CB_HUMAN PIK3CB Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 7.831e-84 1.00
PK3CA_HUMAN PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 9.016e-20 1.00
P85B_HUMAN PIK3R2 Phosphatidylinositol 3-kinase regulatory subunit beta 4.819e-65 0.52
CKX2_ARATH CKX2 Cytokinin dehydrogenase 2 1.074e-51 0.30
AHK3_ARATH AHK3 Histidine kinase 3 6.289e-48 0.35
AHK4_ARATH AHK4 Histidine kinase 4 2.739e-46 0.30
KITH_HHV1 TK Thymidine kinase 3.421e-29 0.32
Q6L709_HHV2 TK Thymidine kinase 6.61e-26 0.32
CHIT_YEAST CTS1 Endochitinase 2.158e-24 0.30
PRIM_HHV11 DNA primase 1.493e-21 0.31
KITH_HHV1S TK Thymidine kinase 2.246e-21 0.32
NR0B1_HUMAN NR0B1 Nuclear receptor subfamily 0 group B member 1 1.576e-08 0.30
TNI3K_HUMAN TNNI3K Serine/threonine-protein kinase TNNI3K 2.431e-08 0.35

Alpelisib

PK3CB_RAT Pik3cb Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 4.805e-136 1.00
PK3CG_HUMAN PIK3CG Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 2.133e-33 1.00
PK3CB_HUMAN PIK3CB Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 6.686e-27 1.00
PK3CA_HUMAN PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 2.344e-24 1.00
PK3CD_HUMAN PIK3CD Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 2.745e-24 1.00
Q9ERT1_MOUSE TRH-R2 Thyrotropin-releasing hormone receptor 2 3.732e-60 0.33
PK3CG_MOUSE Pik3cg Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 8.196e-55 0.35
KCNQ1_HUMAN KCNQ1 Potassium voltage-gated channel subfamily KQT member 1 9.126e-55 0.32
TRFR_MOUSE Trhr Thyrotropin-releasing hormone receptor 3.517e-50 0.33
PI4KB_HUMAN PI4KB Phosphatidylinositol 4-kinase beta 1.3e-25 0.59
PK3C3_HUMAN PIK3C3 Phosphatidylinositol 3-kinase catalytic subunit type 3 3.131e-23 0.37
P3C2B_HUMAN PIK3C2B Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta 4.494e-22 0.61
Q9R297_RAT Mlnr Motilin receptor 8.697e-21 0.29
WNT3_HUMAN WNT3 Proto-oncogene Wnt-3 2.019e-19 0.32
P3C2G_HUMAN PIK3C2G Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma 1.403e-18 0.33
TPP2_RAT Tpp2 Tripeptidyl-peptidase 2 1.932e-18 0.30
SFRP1_HUMAN SFRP1 Secreted frizzled-related protein 1 3.331e-16 0.32
TRPC6_HUMAN TRPC6 Short transient receptor potential channel 6 3.086e-14 0.29
TRPC3_HUMAN TRPC3 Short transient receptor potential channel 3 7.084e-13 0.29
CFAD_HUMAN CFD Complement factor D 2.507e-12 0.39
TRFR_HUMAN TRHR Thyrotropin-releasing hormone receptor 6.464e-12 0.29
SCAF_HCMVA UL80 Capsid scaffolding protein 4.832e-10 0.30
P3C2A_HUMAN PIK3C2A Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha 6.132e-09 0.35
Q9BRH5_HUMAN DGAT1 DGAT1 protein 1.134e-07 0.33
CFTR_HUMAN CFTR Cystic fibrosis transmembrane conductance regulator 3.841e-07 0.31
CCNH_HUMAN CCNH Cyclin-H 3.856e-07 0.32
PRIO_MESAU PRNP Major prion protein 1.119e-06 0.31
GYRB_MYCSM gyrB DNA gyrase subunit B 1.149e-06 0.30
CCND3_HUMAN CCND3 G1/S-specific cyclin-D3 1.277e-06 0.32
CCR1_HUMAN CCR1 C-C chemokine receptor type 1 3.275e-06 0.32
OX1R_RAT Hcrtr1 Orexin receptor type 1 4.565e-06 0.29

Rifamycin

SO2B1_HUMAN SLCO2B1 Solute carrier organic anion transporter family member 2B1 2.9e-124 1.00
SO1B3_HUMAN SLCO1B3 Solute carrier organic anion transporter family member 1B3 8.085e-104 1.00
SO1A4_RAT Slco1a4 Solute carrier organic anion transporter family member 1A4 1.454e-74 1.00
ABCBB_RAT Abcb11 Bile salt export pump 4.629e-39 1.00
SO1A1_RAT Slco1a1 Solute carrier organic anion transporter family member 1A1 9.712e-23 1.00
SO1B1_HUMAN SLCO1B1 Solute carrier organic anion transporter family member 1B1 4.197e-20 1.00
POL_WMSV pol Gag-Pol polyprotein 5.893e-183 0.67
RPOB_MYCTU rpoB DNA-directed RNA polymerase subunit beta 7.319e-168 0.72
DPOLB_MOUSE Polb DNA polymerase beta 4.734e-116 0.65
HSP90_RABIT Heat shock protein HSP 90 7.947e-36 0.28
ENPL_CANLF HSP90B1 Endoplasmin 8.732e-22 0.35
HSP82_YEAST HSP82 ATP-dependent molecular chaperone HSP82 1.188e-07 0.28
NR1I2_HUMAN NR1I2 Nuclear receptor subfamily 1 group I member 2 2e-07 0.71

Vadadustat

EGLN1_HUMAN EGLN1 Egl nine homolog 1 5.258e-118 1.00
VEGFA_HUMAN VEGFA Vascular endothelial growth factor A 8.636e-78 1.00
EGLN3_HUMAN EGLN3 Egl nine homolog 3 7.689e-58 1.00
EGLN1_RAT Egln1 Egl nine homolog 1 2.149e-141 0.52
MMEL1_HUMAN MMEL1 Membrane metallo-endopeptidase-like 1 1.423e-71 0.46
GLR_HUMAN GCGR Glucagon receptor 2.136e-44 0.44
SC6A7_HUMAN SLC6A7 Sodium-dependent proline transporter 9.52e-40 0.37
OXGR1_HUMAN OXGR1 2-oxoglutarate receptor 1 4.892e-39 0.33
GP139_HUMAN GPR139 Probable G-protein coupled receptor 139 7.739e-39 0.37
PDE4D_MOUSE Pde4d cAMP-specific 3',5'-cyclic phosphodiesterase 4D 3.56e-37 0.29
C5ISA2_SHEEP TUBA4A Tubulin alpha chain 3.875e-36 0.29
CATL2_HUMAN CTSV Cathepsin L2 2.378e-35 0.34
BODG_PSESK Gamma-butyrobetaine dioxygenase 2.723e-32 0.44
PDS_SYNE7 pds 15-cis-phytoene desaturase 2.696e-31 0.34
FTO_HUMAN FTO Alpha-ketoglutarate-dependent dioxygenase FTO 1.348e-30 0.44
SUCR1_RAT Sucnr1 Succinate receptor 1 4.345e-25 0.33
ASIC3_RAT Asic3 Acid-sensing ion channel 3 5.245e-24 0.30
PD2R2_RAT Ptgdr2 Prostaglandin D2 receptor 2 2.847e-23 0.29
8ODP_HUMAN NUDT1 7,8-dihydro-8-oxoguanine triphosphatase 2.945e-23 0.38
UREA_CANEN Urease 5.613e-23 0.34
FADS1_HUMAN FADS1 Acyl-CoA (8-3)-desaturase 2.77e-22 0.36
PPGB_HUMAN CTSA Lysosomal protective protein 4.198e-21 0.40
PE2R2_HUMAN PTGER2 Prostaglandin E2 receptor EP2 subtype 5.689e-21 0.34
XPO1_HUMAN XPO1 Exportin-1 8.17e-21 0.33
MMP10_HUMAN MMP10 Stromelysin-2 2.609e-20 0.33
LUCI_AQULA Luciferin 4-monooxygenase 7.745e-20 0.43
EGLN2_HUMAN EGLN2 Egl nine homolog 2 1.488e-19 0.34
SCNAA_MOUSE Scn10a Sodium channel protein type 10 subunit alpha 2.689e-19 0.34
CMA1_RAT Cma1 Chymase 3.983e-19 0.30
MCPT9_MOUSE Mcpt9 Mast cell protease 9 3.983e-19 0.30
CGAS_HUMAN CGAS Cyclic GMP-AMP synthase 8.175e-19 0.36
KMO_HUMAN KMO Kynurenine 3-monooxygenase 8.625e-19 0.39
FABP4_HUMAN FABP4 Fatty acid-binding protein, adipocyte 1.336e-18 0.33
LAT1_HUMAN SLC7A5 Large neutral amino acids transporter small subunit 1 7.088e-18 0.28
GASR_RAT Cckbr Gastrin/cholecystokinin type B receptor 2.249e-17 0.33
GPAT1_MOUSE Gpam Glycerol-3-phosphate acyltransferase 1, mitochondrial 3.422e-17 0.33
ERCC1_HUMAN ERCC1 DNA excision repair protein ERCC-1 1.11e-16 0.30
XPF_HUMAN ERCC4 DNA repair endonuclease XPF 1.11e-16 0.30
PAI1_HUMAN SERPINE1 Plasminogen activator inhibitor 1 3.331e-16 0.38
SUCR1_HUMAN SUCNR1 Succinate receptor 1 5.551e-16 0.33
FABPH_HUMAN FABP3 Fatty acid-binding protein, heart 1.221e-15 0.31
S15A1_HUMAN SLC15A1 Solute carrier family 15 member 1 6.106e-15 0.28
GRM5_HUMAN GRM5 Metabotropic glutamate receptor 5 7.827e-14 0.37
EGFR_MOUSE Egfr Epidermal growth factor receptor 1.225e-13 0.30
PD2R2_MOUSE Ptgdr2 Prostaglandin D2 receptor 2 3.239e-13 0.33
HDAC1_HUMAN HDAC1 Histone deacetylase 1 2.289e-12 0.38
CLK2_MOUSE Clk2 Dual specificity protein kinase CLK2 4.28e-12 0.34
CLK4_MOUSE Clk4 Dual specificity protein kinase CLK4 4.28e-12 0.34
CNR2_HUMAN CNR2 Cannabinoid receptor 2 6.085e-12 0.39
ADRB3_HUMAN ADRB3 Beta-3 adrenergic receptor 6.901e-12 0.33
S22A6_MOUSE Slc22a6 Solute carrier family 22 member 6 2.335e-11 0.33
SMO_MOUSE Smo Smoothened homolog 3.124e-11 0.37
NEP_HUMAN MME Neprilysin 3.963e-11 0.34
GRM5_RAT Grm5 Metabotropic glutamate receptor 5 4.393e-11 0.35
KCMA1_HUMAN KCNMA1 Calcium-activated potassium channel subunit alpha-1 9.335e-11 0.33
ACHG_HUMAN CHRNG Acetylcholine receptor subunit gamma 1.115e-10 0.30
KMO_RAT Kmo Kynurenine 3-monooxygenase 1.498e-10 0.34
ADRB1_HUMAN ADRB1 Beta-1 adrenergic receptor 1.672e-10 0.33
ACHB_HUMAN CHRNB1 Acetylcholine receptor subunit beta 2.343e-10 0.30
SCN2A_HUMAN SCN2A Sodium channel protein type 2 subunit alpha 3.654e-10 0.34
ACHD_HUMAN CHRND Acetylcholine receptor subunit delta 3.725e-10 0.30
PVDQ_PSEAE pvdQ Acyl-homoserine lactone acylase PvdQ 7.896e-10 0.33
GGPPS_YEAST BTS1 Geranylgeranyl pyrophosphate synthase 1.087e-09 0.28
PSBA_MARPO psbA Photosystem II protein D1 2.988e-09 0.29
PDE4D_HUMAN PDE4D cAMP-specific 3',5'-cyclic phosphodiesterase 4D 4.039e-09 0.34
PF2R_BOVIN PTGFR Prostaglandin F2-alpha receptor 4.292e-09 0.29
V1BR_HUMAN AVPR1B Vasopressin V1b receptor 5.3e-09 0.30
ACHA_HUMAN CHRNA1 Acetylcholine receptor subunit alpha 6.489e-09 0.30
F16P1_HUMAN FBP1 Fructose-1,6-bisphosphatase 1 7.829e-09 0.31
CATL1_HUMAN CTSL Cathepsin L1 8.845e-09 0.34
NEP_RAT Mme Neprilysin 1.254e-08 0.32
DPOL_HHV6U U38 DNA polymerase catalytic subunit 1.264e-08 0.31
DYRK3_HUMAN DYRK3 Dual specificity tyrosine-phosphorylation-regulated kinase 3 1.488e-08 0.34
FEN1_HUMAN FEN1 Flap endonuclease 1 1.498e-08 0.34
ARBK2_HUMAN GRK3 Beta-adrenergic receptor kinase 2 1.561e-08 0.30
S15A2_RAT Slc15a2 Solute carrier family 15 member 2 1.566e-08 0.28
RORG_MOUSE Rorc Nuclear receptor ROR-gamma 1.711e-08 0.30
SCNAA_HUMAN SCN10A Sodium channel protein type 10 subunit alpha 1.763e-08 0.34
PDE4B_RAT Pde4b cAMP-specific 3',5'-cyclic phosphodiesterase 4B 2.141e-08 0.32
VE1_HPV11 E1 Replication protein E1 2.207e-08 0.29
CLK1_MOUSE Clk1 Dual specificity protein kinase CLK1 2.767e-08 0.34
CATB_HUMAN CTSB Cathepsin B 2.968e-08 0.32
PD2R2_HUMAN PTGDR2 Prostaglandin D2 receptor 2 3.877e-08 0.38
MMP12_HUMAN MMP12 Macrophage metalloelastase 5.894e-08 0.34
CTBP2_HUMAN CTBP2 C-terminal-binding protein 2 7.347e-08 0.31
HYEP_MOUSE Ephx1 Epoxide hydrolase 1 1.258e-07 0.30
TBA1A_PIG TUBA1A Tubulin alpha-1A chain 1.314e-07 0.32
KCNK9_HUMAN KCNK9 Potassium channel subfamily K member 9 1.941e-07 0.33
ACM1_HUMAN CHRM1 Muscarinic acetylcholine receptor M1 2.149e-07 0.35
MK01_HUMAN MAPK1 Mitogen-activated protein kinase 1 2.214e-07 0.37
DYRK2_HUMAN DYRK2 Dual specificity tyrosine-phosphorylation-regulated kinase 2 2.453e-07 0.34
M4K4_HUMAN MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4 3.892e-07 0.38
CNR2_MOUSE Cnr2 Cannabinoid receptor 2 3.935e-07 0.35
Q8ST54_TRYCR HK Phosphotransferase 4.364e-07 0.31
PIN1_HUMAN PIN1 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 4.818e-07 0.36
DRTS_PLAFK Bifunctional dihydrofolate reductase-thymidylate synthase 5.141e-07 0.30
UFO_HUMAN AXL Tyrosine-protein kinase receptor UFO 5.326e-07 0.36
PRIO_SHEEP PRNP Major prion protein 5.973e-07 0.32
MK10_HUMAN MAPK10 Mitogen-activated protein kinase 10 6.856e-07 0.37
FES_HUMAN FES Tyrosine-protein kinase Fes/Fps 7.777e-07 0.36
P96878_MYCTU Probable transmembrane carbonic anhydrase (Carbonate dehydratase) (Carbonic dehydratase) 8.153e-07 0.31
PTN9_HUMAN PTPN9 Tyrosine-protein phosphatase non-receptor type 9 8.462e-07 0.29
ITK_HUMAN ITK Tyrosine-protein kinase ITK/TSK 8.471e-07 0.33
HDAC2_HUMAN HDAC2 Histone deacetylase 2 9.145e-07 0.36
PI2R_RAT Ptgir Prostacyclin receptor 9.293e-07 0.31
Q56D28_CAVPO CRTH2 Chemoattractant receptor-homologous molecule expressed on Th2 cells 9.396e-07 0.29
CNR1_HUMAN CNR1 Cannabinoid receptor 1 9.501e-07 0.35
Q8MTZ4_9TRYP PPase1 Vacuolar-type proton translocating pyrophosphatase 1 1.071e-06 0.28
CATS_HUMAN CTSS Cathepsin S 1.139e-06 0.34
LOX15_PIG ALOX15 Arachidonate 15-lipoxygenase 1.198e-06 0.28
Q965D5_PLAFA fabI Enoyl-acyl-carrier protein reductase 1.288e-06 0.31
CAN_CANAL NCE103 Carbonic anhydrase 1.329e-06 0.33
SL9A1_HUMAN SLC9A1 Sodium/hydrogen exchanger 1 1.461e-06 0.31
GSK3A_HUMAN GSK3A Glycogen synthase kinase-3 alpha 1.486e-06 0.32
FER_HUMAN FER Tyrosine-protein kinase Fer 1.654e-06 0.36
PTPRC_HUMAN PTPRC Receptor-type tyrosine-protein phosphatase C 1.671e-06 0.33
MARK2_HUMAN MARK2 Serine/threonine-protein kinase MARK2 1.715e-06 0.36
ERCC5_HUMAN ERCC5 DNA repair protein complementing XP-G cells 1.831e-06 0.30
DHB2_HUMAN HSD17B2 Estradiol 17-beta-dehydrogenase 2 1.935e-06 0.33
KDM4B_HUMAN KDM4B Lysine-specific demethylase 4B 2.288e-06 0.33
ATR_HUMAN ATR Serine/threonine-protein kinase ATR 2.769e-06 0.41
PRGR_HUMAN PGR Progesterone receptor 2.787e-06 0.35
PYGL_HUMAN PYGL Glycogen phosphorylase, liver form 4.521e-06 0.32
C3AR_HUMAN C3AR1 C3a anaphylatoxin chemotactic receptor 5.822e-06 0.37

Gepirone

5HT1A_RAT Htr1a 5-hydroxytryptamine receptor 1A 3.706e-116 1.00
5HT1A_HUMAN HTR1A 5-hydroxytryptamine receptor 1A 7.114e-73 1.00
DRD2_HUMAN DRD2 D(2) dopamine receptor 1.839e-40 1.00
5HT2A_HUMAN HTR2A 5-hydroxytryptamine receptor 2A 1.665e-28 1.00
SC6A7_HUMAN SLC6A7 Sodium-dependent proline transporter 1.367e-101 0.40
DRD2_RAT Drd2 D(2) dopamine receptor 1.312e-65 0.73
5HT7R_HUMAN HTR7 5-hydroxytryptamine receptor 7 7.031e-65 0.56
ADA1D_RAT Adra1d Alpha-1D adrenergic receptor 1.048e-64 0.52
ADA1A_RABIT ADRA1A Alpha-1A adrenergic receptor 2.051e-63 0.37
5HT2A_RAT Htr2a 5-hydroxytryptamine receptor 2A 1.684e-62 0.73
5HT7R_RAT Htr7 5-hydroxytryptamine receptor 7 1.247e-44 0.43
DRD4_RAT Drd4 D(4) dopamine receptor 2.606e-38 0.48
ADA1A_RAT Adra1a Alpha-1A adrenergic receptor 1.881e-37 0.73
ADA1B_HUMAN ADRA1B Alpha-1B adrenergic receptor 1.453e-36 0.48
DRD3_HUMAN DRD3 D(3) dopamine receptor 4.532e-35 0.73
ADA1B_MOUSE Adra1b Alpha-1B adrenergic receptor 2.169e-34 0.35
ADA1A_HUMAN ADRA1A Alpha-1A adrenergic receptor 2.348e-31 0.48
DRD4_HUMAN DRD4 D(4) dopamine receptor 7.378e-30 0.56
5HT1A_MOUSE Htr1a 5-hydroxytryptamine receptor 1A 9.423e-29 0.48
DRD5_HUMAN DRD5 D(1B) dopamine receptor 9.004e-26 0.48
P2RX3_RAT P2rx3 P2X purinoceptor 3 2.85e-23 0.35
SGMR1_RAT Sigmar1 Sigma non-opioid intracellular receptor 1 5.048e-22 0.73
ACM2_RAT Chrm2 Muscarinic acetylcholine receptor M2 6.766e-22 0.36
ADA1D_HUMAN ADRA1D Alpha-1D adrenergic receptor 8.034e-22 0.73
ADA1A_BOVIN ADRA1A Alpha-1A adrenergic receptor 2.159e-19 0.48
5HT2A_BOVIN HTR2A 5-hydroxytryptamine receptor 2A 2.272e-17 0.73
NOS2_MOUSE Nos2 Nitric oxide synthase, inducible 5.02e-17 0.31
ACM4_RAT Chrm4 Muscarinic acetylcholine receptor M4 1.11e-16 0.36
ACM1_RAT Chrm1 Muscarinic acetylcholine receptor M1 3.331e-16 0.36
VATB1_HUMAN ATP6V1B1 V-type proton ATPase subunit B, kidney isoform 8.882e-16 0.35
VPP1_CHICK ATP6V0A1 V-type proton ATPase 116 kDa subunit a isoform 1 8.882e-16 0.35
DRD2_MOUSE Drd2 D(2) dopamine receptor 1.11e-15 0.33
H10_HUMAN H1-0 Histone H1.0 1.443e-15 0.30
DRD3_RAT Drd3 D(3) dopamine receptor 6.439e-15 0.37
5HT2C_RAT Htr2c 5-hydroxytryptamine receptor 2C 1.443e-14 0.73
ACM3_RAT Chrm3 Muscarinic acetylcholine receptor M3 1.249e-13 0.36
NLRP1_HUMAN NLRP1 NACHT, LRR and PYD domains-containing protein 1 2.482e-13 0.29
DRD1_HUMAN DRD1 D(1A) dopamine receptor 1.096e-12 0.48
DRD1_PIG DRD1 D(1A) dopamine receptor 3.937e-12 0.36
TYTR_TRYCR TPR Trypanothione reductase 4.87e-12 0.33
AMPC_CITFR ampC Beta-lactamase 8.017e-12 0.29
BLAC_BACLI penP Beta-lactamase 8.017e-12 0.29
S47A1_HUMAN SLC47A1 Multidrug and toxin extrusion protein 1 1.853e-11 0.73
ADA2A_BOVIN ADRA2A Alpha-2A adrenergic receptor 1.924e-11 0.73
NMD3A_RAT Grin3a Glutamate receptor ionotropic, NMDA 3A 3.551e-11 0.33
SGMR1_HUMAN SIGMAR1 Sigma non-opioid intracellular receptor 1 1.131e-10 0.73
DRD2_BOVIN DRD2 D(2) dopamine receptor 4.242e-10 0.73
5HT2A_PIG HTR2A 5-hydroxytryptamine receptor 2A 5.421e-10 0.30
HRH1_HUMAN HRH1 Histamine H1 receptor 8.756e-10 0.47
EBP_CAVPO EBP 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase 9.032e-09 0.29
HRH3_CAVPO HRH3 Histamine H3 receptor 1.009e-08 0.31
G3I1B6_CRIGR 5-hydroxytryptamine receptor 1.917e-08 0.29
5HT1B_CRIGR HTR1B 5-hydroxytryptamine receptor 1B 2.398e-08 0.29
5HT1B_RAT Htr1b 5-hydroxytryptamine receptor 1B 2.676e-08 0.37
ACM1_DROME mAChR-A Muscarinic acetylcholine receptor DM1 4.208e-08 0.32
SOAT1_HUMAN SOAT1 Sterol O-acyltransferase 1 4.283e-08 0.45
SGMR1_CAVPO SIGMAR1 Sigma non-opioid intracellular receptor 1 4.406e-08 0.38
ACES_ELEEL ache Acetylcholinesterase 1.676e-07 0.37
5HT2C_HUMAN HTR2C 5-hydroxytryptamine receptor 2C 2.446e-07 0.73
5HT6R_HUMAN HTR6 5-hydroxytryptamine receptor 6 2.8e-07 0.37
KCNH2_CAVPO KCNH2 Potassium voltage-gated channel subfamily H member 2 1.683e-06 0.29
ADA2C_HUMAN ADRA2C Alpha-2C adrenergic receptor 3.844e-06 0.47
SCN2A_RAT Scn2a Sodium channel protein type 2 subunit alpha 7.331e-06 0.31

Neratinib

ERBB2_HUMAN ERBB2 Receptor tyrosine-protein kinase erbB-2 6.345e-115 1.00
EGFR_HUMAN EGFR Epidermal growth factor receptor 6.066e-109 1.00
ERBB4_HUMAN ERBB4 Receptor tyrosine-protein kinase erbB-4 1.234e-88 1.00
SRC_HUMAN SRC Proto-oncogene tyrosine-protein kinase Src 1.394e-71 1.00
WEE2_HUMAN WEE2 Wee1-like protein kinase 2 5.093e-52 1.00
ST32B_HUMAN STK32B Serine/threonine-protein kinase 32B 1.025e-48 1.00
STK24_HUMAN STK24 Serine/threonine-protein kinase 24 2.85e-41 1.00
M3K4_HUMAN MAP3K4 Mitogen-activated protein kinase kinase kinase 4 2.024e-38 1.00
MP2K1_HUMAN MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 7.329e-38 1.00
NEK3_HUMAN NEK3 Serine/threonine-protein kinase Nek3 2.191e-35 1.00
STK25_HUMAN STK25 Serine/threonine-protein kinase 25 5.594e-34 1.00
MAST1_HUMAN MAST1 Microtubule-associated serine/threonine-protein kinase 1 2.004e-33 1.00
STK36_HUMAN STK36 Serine/threonine-protein kinase 36 4.616e-33 1.00
STK4_HUMAN STK4 Serine/threonine-protein kinase 4 6.024e-30 1.00
MELK_HUMAN MELK Maternal embryonic leucine zipper kinase 3.263e-29 1.00
ERBB3_HUMAN ERBB3 Receptor tyrosine-protein kinase erbB-3 7.754e-29 1.00
M4K3_HUMAN MAP4K3 Mitogen-activated protein kinase kinase kinase kinase 3 5.957e-27 1.00
NUAK2_HUMAN NUAK2 NUAK family SNF1-like kinase 2 5.957e-27 1.00
M4K1_HUMAN MAP4K1 Mitogen-activated protein kinase kinase kinase kinase 1 5.922e-26 1.00
CDK16_HUMAN CDK16 Cyclin-dependent kinase 16 1.725e-25 1.00
STK10_HUMAN STK10 Serine/threonine-protein kinase 10 1.113e-24 1.00
DUSTY_HUMAN DSTYK Dual serine/threonine and tyrosine protein kinase 4.103e-24 1.00
TIE1_HUMAN TIE1 Tyrosine-protein kinase receptor Tie-1 7.943e-24 1.00
M3K13_HUMAN MAP3K13 Mitogen-activated protein kinase kinase kinase 13 2.246e-23 1.00
STK35_HUMAN STK35 Serine/threonine-protein kinase 35 1.082e-22 1.00
TXK_HUMAN TXK Tyrosine-protein kinase TXK 3.41e-22 1.00
SIK2_HUMAN SIK2 Serine/threonine-protein kinase SIK2 4.266e-22 1.00
E2AK4_HUMAN EIF2AK4 eIF-2-alpha kinase GCN2 2.138e-20 1.00
PAK6_HUMAN PAK6 Serine/threonine-protein kinase PAK 6 2.176e-19 1.00
EPHB6_HUMAN EPHB6 Ephrin type-B receptor 6 2.858e-19 1.00
M3K3_HUMAN MAP3K3 Mitogen-activated protein kinase kinase kinase 3 4.904e-19 1.00
STK33_HUMAN STK33 Serine/threonine-protein kinase 33 5.367e-19 1.00
INSRR_HUMAN INSRR Insulin receptor-related protein 9.774e-19 1.00
SIK1_HUMAN SIK1 Serine/threonine-protein kinase SIK1 3.018e-18 1.00
MP2K5_HUMAN MAP2K5 Dual specificity mitogen-activated protein kinase kinase 5 5.764e-18 1.00
GAK_HUMAN GAK Cyclin-G-associated kinase 2.655e-17 1.00
M3K2_HUMAN MAP3K2 Mitogen-activated protein kinase kinase kinase 2 3.298e-17 1.00
PAK2_HUMAN PAK2 Serine/threonine-protein kinase PAK 2 3.298e-17 1.00
STK26_HUMAN STK26 Serine/threonine-protein kinase 26 3.298e-17 1.00
FGR_HUMAN FGR Tyrosine-protein kinase Fgr 2.22e-16 1.00
CSK_HUMAN CSK Tyrosine-protein kinase CSK 3.331e-16 1.00
NUAK1_HUMAN NUAK1 NUAK family SNF1-like kinase 1 4.774e-15 1.00
KCC1D_HUMAN CAMK1D Calcium/calmodulin-dependent protein kinase type 1D 1.31e-14 1.00
FES_HUMAN FES Tyrosine-protein kinase Fes/Fps 8.404e-14 1.00
ST17B_HUMAN STK17B Serine/threonine-protein kinase 17B 1.721e-12 1.00
LYN_HUMAN LYN Tyrosine-protein kinase Lyn 2.189e-12 1.00
M3K19_HUMAN MAP3K19 Mitogen-activated protein kinase kinase kinase 19 2.829e-12 1.00
M3K11_HUMAN MAP3K11 Mitogen-activated protein kinase kinase kinase 11 3.831e-12 1.00
CSF1R_HUMAN CSF1R Macrophage colony-stimulating factor 1 receptor 3.957e-12 1.00
IGF1R_HUMAN IGF1R Insulin-like growth factor 1 receptor 9.253e-12 1.00
FYN_HUMAN FYN Tyrosine-protein kinase Fyn 1.524e-11 1.00
VGFR2_HUMAN KDR Vascular endothelial growth factor receptor 2 1.963e-11 1.00
M3K9_HUMAN MAP3K9 Mitogen-activated protein kinase kinase kinase 9 6.683e-11 1.00
YES_HUMAN YES1 Tyrosine-protein kinase Yes 8.469e-11 1.00
M3K10_HUMAN MAP3K10 Mitogen-activated protein kinase kinase kinase 10 9.605e-11 1.00
FER_HUMAN FER Tyrosine-protein kinase Fer 2.269e-10 1.00
MP2K2_HUMAN MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 2.517e-10 1.00
TNIK_HUMAN TNIK TRAF2 and NCK-interacting protein kinase 5.538e-10 1.00
M3K20_HUMAN MAP3K20 Mitogen-activated protein kinase kinase kinase 20 1.984e-08 1.00
JAK3_HUMAN JAK3 Tyrosine-protein kinase JAK3 2.397e-08 1.00
TAOK3_HUMAN TAOK3 Serine/threonine-protein kinase TAO3 2.423e-08 1.00
BLK_HUMAN BLK Tyrosine-protein kinase Blk 6.285e-08 1.00
SLK_HUMAN SLK STE20-like serine/threonine-protein kinase 1.577e-07 1.00
MERTK_HUMAN MERTK Tyrosine-protein kinase Mer 1.594e-07 1.00
WEE1_HUMAN WEE1 Wee1-like protein kinase 2.756e-07 1.00
ST17A_HUMAN STK17A Serine/threonine-protein kinase 17A 7.326e-07 1.00
KC1E_HUMAN CSNK1E Casein kinase I isoform epsilon 8.018e-07 1.00
HCK_HUMAN HCK Tyrosine-protein kinase HCK 9.481e-07 1.00
MP2K7_HUMAN MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 1.04e-06 1.00
NEK2_HUMAN NEK2 Serine/threonine-protein kinase Nek2 1.091e-06 1.00
KS6A1_HUMAN RPS6KA1 Ribosomal protein S6 kinase alpha-1 1.164e-06 1.00
KS6A2_HUMAN RPS6KA2 Ribosomal protein S6 kinase alpha-2 1.48e-06 1.00
PAK1_HUMAN PAK1 Serine/threonine-protein kinase PAK 1 1.633e-06 1.00
ABL1_HUMAN ABL1 Tyrosine-protein kinase ABL1 1.987e-06 1.00
BTK_HUMAN BTK Tyrosine-protein kinase BTK 4.397e-06 1.00
UFO_HUMAN AXL Tyrosine-protein kinase receptor UFO 6.918e-06 1.00
HIPK4_HUMAN HIPK4 Homeodomain-interacting protein kinase 4 8.554e-06 1.00
STK3_HUMAN STK3 Serine/threonine-protein kinase 3 9.253e-06 1.00
IRAK1_HUMAN IRAK1 Interleukin-1 receptor-associated kinase 1 9.664e-06 1.00
KPCD1_HUMAN PRKD1 Serine/threonine-protein kinase D1 9.927e-06 1.00
M4K5_HUMAN MAP4K5 Mitogen-activated protein kinase kinase kinase kinase 5 1.469e-05 1.00
RON_HUMAN MST1R Macrophage-stimulating protein receptor 2.096e-05 1.00
MK10_HUMAN MAPK10 Mitogen-activated protein kinase 10 2.318e-05 1.00
INSR_HUMAN INSR Insulin receptor 2.599e-05 1.00
KC1G3_HUMAN CSNK1G3 Casein kinase I isoform gamma-3 5.43e-05 1.00
CDK7_HUMAN CDK7 Cyclin-dependent kinase 7 0.0001386 1.00
ACK1_HUMAN TNK2 Activated CDC42 kinase 1 0.000207 1.00
FAK2_HUMAN PTK2B Protein-tyrosine kinase 2-beta 0.0003044 1.00
MINK1_HUMAN MINK1 Misshapen-like kinase 1 0.0006815 1.00
M4K4_HUMAN MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4 0.0009439 1.00
KC1G2_HUMAN CSNK1G2 Casein kinase I isoform gamma-2 0.0009614 1.00
TIE2_HUMAN TEK Angiopoietin-1 receptor 0.001087 1.00
LCK_HUMAN LCK Tyrosine-protein kinase Lck 0.001369 1.00
KPCD3_HUMAN PRKD3 Serine/threonine-protein kinase D3 0.001696 1.00
MK08_HUMAN MAPK8 Mitogen-activated protein kinase 8 0.002567 1.00
M4K2_HUMAN MAP4K2 Mitogen-activated protein kinase kinase kinase kinase 2 0.002968 1.00
KPCD2_HUMAN PRKD2 Serine/threonine-protein kinase D2 0.006479 1.00
CHK1_HUMAN CHEK1 Serine/threonine-protein kinase Chk1 0.01307 1.00
CHK2_HUMAN CHEK2 Serine/threonine-protein kinase Chk2 0.01326 1.00
M3K12_HUMAN MAP3K12 Mitogen-activated protein kinase kinase kinase 12 0.01458 1.00
FAK1_HUMAN PTK2 Focal adhesion kinase 1 0.01915 1.00
MET_HUMAN MET Hepatocyte growth factor receptor 0.03259 1.00
FLT3_HUMAN FLT3 Receptor-type tyrosine-protein kinase FLT3 0.03503 1.00
KSYK_HUMAN SYK Tyrosine-protein kinase SYK 0.09579 1.00
M3K8_HUMAN MAP3K8 Mitogen-activated protein kinase kinase kinase 8 1.479e-119 0.45
SRC_RAT Src Proto-oncogene tyrosine-protein kinase Src 1.164e-67 0.36
DUS2L_HUMAN DUS2 tRNA-dihydrouridine(20) synthase [NAD(P)+]-like 2.931e-43 0.34
STK3_MOUSE Stk3 Serine/threonine-protein kinase 3 3.865e-33 0.75
ULK3_MOUSE Ulk3 Serine/threonine-protein kinase ULK3 1.69e-29 0.75
KC1AL_HUMAN CSNK1A1L Casein kinase I isoform alpha-like 5.513e-26 0.75
PMYT1_HUMAN PKMYT1 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase 8.553e-26 0.75
PHKG1_HUMAN PHKG1 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 7.547e-22 0.75
ST38L_HUMAN STK38L Serine/threonine-protein kinase 38-like 2.531e-21 0.75
TBA1A_RAT Tuba1a Tubulin alpha-1A chain 2.531e-21 0.75
PDE5A_CANLF PDE5A cGMP-specific 3',5'-cyclic phosphodiesterase 4.864e-21 0.33
CTRO_HUMAN CIT Citron Rho-interacting kinase 2.622e-19 0.75
EPHA6_HUMAN EPHA6 Ephrin type-A receptor 6 2.689e-18 0.75
BLK_MOUSE Blk Tyrosine-protein kinase Blk 6.108e-18 0.34
COQ8B_HUMAN COQ8B Atypical kinase COQ8B, mitochondrial 3.044e-17 0.75
DMPK_HUMAN DMPK Myotonin-protein kinase 3.714e-17 0.75
DCLK3_HUMAN DCLK3 Serine/threonine-protein kinase DCLK3 2.22e-16 0.75
EPHA5_HUMAN EPHA5 Ephrin type-A receptor 5 1.221e-15 0.75
VRK2_HUMAN VRK2 Serine/threonine-protein kinase VRK2 1.332e-15 0.34
BMP2K_HUMAN BMP2K BMP-2-inducible protein kinase 5.551e-15 0.75
EPHA8_HUMAN EPHA8 Ephrin type-A receptor 8 5.551e-15 0.75
PI42B_HUMAN PIP4K2B Phosphatidylinositol 5-phosphate 4-kinase type-2 beta 8.737e-14 0.75
EPHB1_HUMAN EPHB1 Ephrin type-B receptor 1 1.245e-13 0.75
MARK1_HUMAN MARK1 Serine/threonine-protein kinase MARK1 5.478e-13 0.75
KKCC1_HUMAN CAMKK1 Calcium/calmodulin-dependent protein kinase kinase 1 2.661e-12 0.75
AAK1_HUMAN AAK1 AP2-associated protein kinase 1 3.436e-12 0.75
MYLK2_HUMAN MYLK2 Myosin light chain kinase 2, skeletal/cardiac muscle 1.055e-11 0.75
NEK11_HUMAN NEK11 Serine/threonine-protein kinase Nek11 1.142e-11 0.34
STK39_RAT Stk39 STE20/SPS1-related proline-alanine-rich protein kinase 5.659e-11 0.29
EPHA3_HUMAN EPHA3 Ephrin type-A receptor 3 5.943e-11 0.75
ABL2_HUMAN ABL2 Tyrosine-protein kinase ABL2 8.065e-11 0.75
KS6A6_HUMAN RPS6KA6 Ribosomal protein S6 kinase alpha-6 1.139e-10 0.42
KKCC2_HUMAN CAMKK2 Calcium/calmodulin-dependent protein kinase kinase 2 1.444e-10 0.75
DYR1A_MOUSE Dyrk1a Dual specificity tyrosine-phosphorylation-regulated kinase 1A 2.284e-10 0.30
MCHR2_HUMAN MCHR2 Melanin-concentrating hormone receptor 2 4.787e-10 0.30
BKRB2_HUMAN BDKRB2 B2 bradykinin receptor 1.075e-09 0.32
F16P1_PIG FBP1 Fructose-1,6-bisphosphatase 1 1.274e-09 0.30
TLK2_HUMAN TLK2 Serine/threonine-protein kinase tousled-like 2 1.326e-09 0.34
CLK3_HUMAN CLK3 Dual specificity protein kinase CLK3 1.684e-09 0.75
CSKP_HUMAN CASK Peripheral plasma membrane protein CASK 4.14e-09 0.34
MYO3A_HUMAN MYO3A Myosin-IIIa 4.14e-09 0.34
STK39_HUMAN STK39 STE20/SPS1-related proline-alanine-rich protein kinase 4.14e-09 0.34
SBK1_HUMAN SBK1 Serine/threonine-protein kinase SBK1 6.974e-09 0.42
E2AK2_HUMAN EIF2AK2 Interferon-induced, double-stranded RNA-activated protein kinase 7.916e-09 0.75
MYO3B_HUMAN MYO3B Myosin-IIIb 1.117e-08 0.34
ST32A_HUMAN STK32A Serine/threonine-protein kinase 32A 1.117e-08 0.34
PGFRB_HUMAN PDGFRB Platelet-derived growth factor receptor beta 1.18e-08 0.37
SIK3_HUMAN SIK3 Serine/threonine-protein kinase SIK3 2.68e-08 0.34
TLK1_HUMAN TLK1 Serine/threonine-protein kinase tousled-like 1 2.68e-08 0.34
PHKG2_HUMAN PHKG2 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 3.28e-08 0.75
HUNK_HUMAN HUNK Hormonally up-regulated neu tumor-associated kinase 5.837e-08 0.34
M3K1_HUMAN MAP3K1 Mitogen-activated protein kinase kinase kinase 1 5.837e-08 0.34
NIM1_HUMAN NIM1K Serine/threonine-protein kinase NIM1 5.837e-08 0.34
UBP47_HUMAN USP47 Ubiquitin carboxyl-terminal hydrolase 47 8.238e-08 0.29
CDK15_HUMAN CDK15 Cyclin-dependent kinase 15 1.173e-07 0.34
GRM4_RAT Grm4 Metabotropic glutamate receptor 4 4.158e-07 0.32
CDK14_HUMAN CDK14 Cyclin-dependent kinase 14 1.062e-06 0.34
MP2K6_HUMAN MAP2K6 Dual specificity mitogen-activated protein kinase kinase 6 1.062e-06 0.34
BKRB2_CAVPO BDKRB2 B2 bradykinin receptor 1.132e-06 0.32
RIPK2_HUMAN RIPK2 Receptor-interacting serine/threonine-protein kinase 2 1.647e-06 0.42
BMX_HUMAN BMX Cytoplasmic tyrosine-protein kinase BMX 1.773e-06 0.75
ANKK1_HUMAN ANKK1 Ankyrin repeat and protein kinase domain-containing protein 1 2.486e-06 0.34
PI51A_HUMAN PIP5K1A Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha 2.486e-06 0.34
C3SLB7_ECOLX glmU Bifunctional protein GlmU 4.862e-06 0.28
RIOK1_HUMAN RIOK1 Serine/threonine-protein kinase RIO1 5.174e-06 0.34
RIOK3_HUMAN RIOK3 Serine/threonine-protein kinase RIO3 5.174e-06 0.34
ULK3_HUMAN ULK3 Serine/threonine-protein kinase ULK3 5.174e-06 0.34
EPHA2_HUMAN EPHA2 Ephrin type-A receptor 2 7.052e-06 0.34
BMPR2_HUMAN BMPR2 Bone morphogenetic protein receptor type-2 7.199e-06 0.34
SRPK3_HUMAN SRPK3 SRSF protein kinase 3 7.199e-06 0.34
EPHB4_HUMAN EPHB4 Ephrin type-B receptor 4 8.328e-06 0.75
FRK_HUMAN FRK Tyrosine-protein kinase FRK 8.84e-06 0.75
GRK4_HUMAN GRK4 G protein-coupled receptor kinase 4 9.811e-06 0.34

Acalabrutinib

BTK_HUMAN BTK Tyrosine-protein kinase BTK 1.23e-102 1.00
ACK1_HUMAN TNK2 Activated CDC42 kinase 1 9.766e-212 0.50
PRIO_SHEEP PRNP Major prion protein 3.67e-37 0.35
TEC_HUMAN TEC Tyrosine-protein kinase Tec 4.522e-32 0.42
IGF1R_HUMAN IGF1R Insulin-like growth factor 1 receptor 1.06e-24 0.43
SEPR_MOUSE Fap Prolyl endopeptidase FAP 3.502e-24 0.30
TXK_HUMAN TXK Tyrosine-protein kinase TXK 1.74e-20 0.42
PPID_HUMAN PPID Peptidyl-prolyl cis-trans isomerase D 7.565e-20 0.29
SRMS_HUMAN SRMS Tyrosine-protein kinase Srms 1.048e-18 0.42
FGR_HUMAN FGR Tyrosine-protein kinase Fgr 4.923e-18 0.42
CSK_HUMAN CSK Tyrosine-protein kinase CSK 7.091e-18 0.42
PPIG_HUMAN PPIG Peptidyl-prolyl cis-trans isomerase G 9.669e-18 0.29
BMX_HUMAN BMX Cytoplasmic tyrosine-protein kinase BMX 3.808e-13 0.42
LUCI_AQULA Luciferin 4-monooxygenase 3.78e-12 0.35
YES_HUMAN YES1 Tyrosine-protein kinase Yes 6.849e-12 0.42
FRK_HUMAN FRK Tyrosine-protein kinase FRK 4.662e-11 0.42
PTK6_HUMAN PTK6 Protein-tyrosine kinase 6 8.367e-11 0.42
PPIB_HUMAN PPIB Peptidyl-prolyl cis-trans isomerase B 8.581e-11 0.29
ERBB4_HUMAN ERBB4 Receptor tyrosine-protein kinase erbB-4 1.314e-10 0.42
CPT1A_RAT Cpt1a Carnitine O-palmitoyltransferase 1, liver isoform 2.186e-09 0.32
CPT1A_HUMAN CPT1A Carnitine O-palmitoyltransferase 1, liver isoform 3.05e-09 0.32
BLK_HUMAN BLK Tyrosine-protein kinase Blk 2.115e-08 0.42
TRPV1_RAT Trpv1 Transient receptor potential cation channel subfamily V member 1 6.91e-08 0.33
PPCE_HUMAN PREP Prolyl endopeptidase 2.254e-07 0.30
LYN_HUMAN LYN Tyrosine-protein kinase Lyn 2.917e-07 0.42
Q9BRH5_HUMAN DGAT1 DGAT1 protein 6.454e-07 0.29
GYRB_MYCS2 gyrB DNA gyrase subunit B 6.887e-07 0.29
5HT1F_HUMAN HTR1F 5-hydroxytryptamine receptor 1F 9.236e-07 0.33
CPT1B_RAT Cpt1b Carnitine O-palmitoyltransferase 1, muscle isoform 9.396e-07 0.29
LCK_HUMAN LCK Tyrosine-protein kinase Lck 4.247e-06 0.42
S22A8_HUMAN SLC22A8 Solute carrier family 22 member 8 6.166e-06 0.29
FYN_HUMAN FYN Tyrosine-protein kinase Fyn 7.071e-06 0.42

Relugolix

GNRHR_HUMAN GNRHR Gonadotropin-releasing hormone receptor 6.706e-99 1.00
GNRHR_RAT Gnrhr Gonadotropin-releasing hormone receptor 5.233e-09 1.00
G7P5Q7_MACFA Gonadotropin-releasing hormone receptor 2.812e-112 0.72
GNRHR_MACMU GNRHR Gonadotropin-releasing hormone receptor 1.016e-17 0.39

Tivozanib

VGFR2_HUMAN KDR Vascular endothelial growth factor receptor 2 7.547e-98 1.00
PGFRA_HUMAN PDGFRA Platelet-derived growth factor receptor alpha 8.987e-67 1.00
VGFR1_HUMAN FLT1 Vascular endothelial growth factor receptor 1 2.109e-31 1.00
VGFR3_HUMAN FLT4 Vascular endothelial growth factor receptor 3 1.886e-27 1.00
EPHB2_HUMAN EPHB2 Ephrin type-B receptor 2 1.915e-26 1.00
MET_HUMAN MET Hepatocyte growth factor receptor 6.762e-97 0.66
PGFRB_RAT Pdgfrb Platelet-derived growth factor receptor beta 4.211e-90 0.51
EPHA2_HUMAN EPHA2 Ephrin type-A receptor 2 1.426e-70 0.40
EPHB4_HUMAN EPHB4 Ephrin type-B receptor 4 3.373e-58 0.34
PGFRB_HUMAN PDGFRB Platelet-derived growth factor receptor beta 2.113e-50 0.53
BRAF_HUMAN BRAF Serine/threonine-protein kinase B-raf 1.172e-44 0.54
MK12_HUMAN MAPK12 Mitogen-activated protein kinase 12 3.837e-41 0.36
HGF_HUMAN HGF Hepatocyte growth factor 2.253e-40 0.32
DUS2L_HUMAN DUS2 tRNA-dihydrouridine(20) synthase [NAD(P)+]-like 1.551e-39 0.31
EGFR_HUMAN EGFR Epidermal growth factor receptor 1.283e-37 0.53
CSF1R_HUMAN CSF1R Macrophage colony-stimulating factor 1 receptor 7.206e-34 0.53
PFKA_TRYBB pfk ATP-dependent 6-phosphofructokinase 1.518e-32 0.32
PYGL_MOUSE Pygl Glycogen phosphorylase, liver form 3.512e-32 0.32
PFKA_TRYCC pfk ATP-dependent 6-phosphofructokinase 3.278e-30 0.30
PYGL_RAT Pygl Glycogen phosphorylase, liver form 1.501e-29 0.32
RON_HUMAN MST1R Macrophage-stimulating protein receptor 3.169e-28 0.53
TIE2_HUMAN TEK Angiopoietin-1 receptor 9.458e-28 0.54
RET_HUMAN RET Proto-oncogene tyrosine-protein kinase receptor Ret 9.072e-27 0.59
HCK_HUMAN HCK Tyrosine-protein kinase HCK 4.545e-26 0.53
FLT3_HUMAN FLT3 Receptor-type tyrosine-protein kinase FLT3 1.452e-23 0.53
G3V783_RAT Ripk2 Receptor-interacting serine/threonine-protein kinase 2 2.063e-23 0.29
RAF1_HUMAN RAF1 RAF proto-oncogene serine/threonine-protein kinase 2.44e-23 0.41
KIT_HUMAN KIT Mast/stem cell growth factor receptor Kit 2.692e-23 0.61
PDE3B_HUMAN PDE3B cGMP-inhibited 3',5'-cyclic phosphodiesterase B 1.708e-22 0.30
VGFR2_DANRE kdr Vascular endothelial growth factor receptor 2 6.98e-22 0.31
CDKL3_HUMAN CDKL3 Cyclin-dependent kinase-like 3 5.66e-21 0.34
SRC_HUMAN SRC Proto-oncogene tyrosine-protein kinase Src 6.34e-21 0.53
LCK_HUMAN LCK Tyrosine-protein kinase Lck 2.744e-20 0.54
ACVR1_HUMAN ACVR1 Activin receptor type-1 8.629e-20 0.41
CDPK1_PLAF7 CPK1 Calcium-dependent protein kinase 1 3.21e-19 0.53
RIPK2_HUMAN RIPK2 Receptor-interacting serine/threonine-protein kinase 2 3.61e-19 0.53
MECP2_HUMAN MECP2 Methyl-CpG-binding protein 2 1.211e-18 0.30
NLK_HUMAN NLK Serine/threonine-protein kinase NLK 1.301e-18 0.53
GRM4_RAT Grm4 Metabotropic glutamate receptor 4 3.891e-18 0.31
NEK11_HUMAN NEK11 Serine/threonine-protein kinase Nek11 1.606e-17 0.53
PYGM_HUMAN PYGM Glycogen phosphorylase, muscle form 2.176e-17 0.32
CHK1_HUMAN CHEK1 Serine/threonine-protein kinase Chk1 3.042e-17 0.38
MET_MOUSE Met Hepatocyte growth factor receptor 2.22e-16 0.36
FAK2_MOUSE Ptk2b Protein-tyrosine kinase 2-beta 3.331e-16 0.43
O77823_PIG PDE4A Cyclic AMP-specific phosphodiesterase SSPDE4A1A 4.441e-16 0.35
EPHA8_HUMAN EPHA8 Ephrin type-A receptor 8 6.661e-16 0.53
TESK1_HUMAN TESK1 Dual specificity testis-specific protein kinase 1 7.772e-16 0.53
A5H660_SCHMA HDAC8 Histone deacetylase 8 1.443e-15 0.30
FGR_HUMAN FGR Tyrosine-protein kinase Fgr 1.554e-15 0.53
MYO3B_HUMAN MYO3B Myosin-IIIb 1.887e-15 0.34
FGFR2_HUMAN FGFR2 Fibroblast growth factor receptor 2 2.331e-15 0.61
ERBB2_HUMAN ERBB2 Receptor tyrosine-protein kinase erbB-2 2.998e-15 0.34
PDE3A_HUMAN PDE3A cGMP-inhibited 3',5'-cyclic phosphodiesterase A 6.106e-15 0.30
EPHA1_HUMAN EPHA1 Ephrin type-A receptor 1 1.776e-14 0.53
HIPK4_HUMAN HIPK4 Homeodomain-interacting protein kinase 4 1.943e-14 0.53
FAK2_HUMAN PTK2B Protein-tyrosine kinase 2-beta 2.942e-14 0.44
UFO_HUMAN AXL Tyrosine-protein kinase receptor UFO 3.508e-14 0.53
ERBB4_HUMAN ERBB4 Receptor tyrosine-protein kinase erbB-4 7.35e-14 0.53
AURKB_HUMAN AURKB Aurora kinase B 1.253e-13 0.53
CDK15_HUMAN CDK15 Cyclin-dependent kinase 15 1.427e-13 0.34
IGF1R_HUMAN IGF1R Insulin-like growth factor 1 receptor 1.779e-13 0.66
ERBB3_HUMAN ERBB3 Receptor tyrosine-protein kinase erbB-3 2.947e-13 0.34
IRAK3_HUMAN IRAK3 Interleukin-1 receptor-associated kinase 3 4.012e-13 0.53
PYGL_HUMAN PYGL Glycogen phosphorylase, liver form 4.222e-13 0.33
EPHB6_HUMAN EPHB6 Ephrin type-B receptor 6 6.062e-13 0.53
ABL1_MOUSE Abl1 Tyrosine-protein kinase ABL1 6.478e-13 0.30
STK4_HUMAN STK4 Serine/threonine-protein kinase 4 7.923e-13 0.53
GSK3A_HUMAN GSK3A Glycogen synthase kinase-3 alpha 9.837e-13 0.36
AURKA_HUMAN AURKA Aurora kinase A 1.104e-12 0.53
PVDQ_PSEAE pvdQ Acyl-homoserine lactone acylase PvdQ 1.862e-12 0.39
CLK4_HUMAN CLK4 Dual specificity protein kinase CLK4 2.062e-12 0.42
MYLK3_HUMAN MYLK3 Myosin light chain kinase 3 3.4e-12 0.34
SRPK1_HUMAN SRPK1 SRSF protein kinase 1 3.981e-12 0.42
MP2K5_HUMAN MAP2K5 Dual specificity mitogen-activated protein kinase kinase 5 4.45e-12 0.53
CSK_HUMAN CSK Tyrosine-protein kinase CSK 5.73e-12 0.53
CDK14_HUMAN CDK14 Cyclin-dependent kinase 14 8.203e-12 0.34
STK10_HUMAN STK10 Serine/threonine-protein kinase 10 9.004e-12 0.53
C3SLB7_ECOLX glmU Bifunctional protein GlmU 1.476e-11 0.29
ABL2_HUMAN ABL2 Tyrosine-protein kinase ABL2 1.742e-11 0.53
CDK17_HUMAN CDK17 Cyclin-dependent kinase 17 1.846e-11 0.34
MK14_HUMAN MAPK14 Mitogen-activated protein kinase 14 3.464e-11 0.44
CDKL2_HUMAN CDKL2 Cyclin-dependent kinase-like 2 7.841e-11 0.34
MUSK_HUMAN MUSK Muscle, skeletal receptor tyrosine-protein kinase 7.841e-11 0.34
MAK_HUMAN MAK Serine/threonine-protein kinase MAK 8.923e-11 0.34
M3K19_HUMAN MAP3K19 Mitogen-activated protein kinase kinase kinase 19 1.006e-10 0.53
CSF1R_MOUSE Csf1r Macrophage colony-stimulating factor 1 receptor 1.066e-10 0.32
STK36_HUMAN STK36 Serine/threonine-protein kinase 36 1.499e-10 0.34
F16P1_PIG FBP1 Fructose-1,6-bisphosphatase 1 3.683e-10 0.32
M4K5_HUMAN MAP4K5 Mitogen-activated protein kinase kinase kinase kinase 5 4.253e-10 0.53
MYLK2_HUMAN MYLK2 Myosin light chain kinase 2, skeletal/cardiac muscle 4.843e-10 0.34
Q6UCJ9_TOXGO ENR Enoyl-acyl carrier reductase 5.279e-10 0.35
DDR2_HUMAN DDR2 Discoidin domain-containing receptor 2 7.5e-10 0.53
MK15_HUMAN MAPK15 Mitogen-activated protein kinase 15 8.247e-10 0.34
SRMS_HUMAN SRMS Tyrosine-protein kinase Srms 1.051e-09 0.53
EPHA7_HUMAN EPHA7 Ephrin type-A receptor 7 1.361e-09 0.34
TNK1_HUMAN TNK1 Non-receptor tyrosine-protein kinase TNK1 1.361e-09 0.34
MP2K2_HUMAN MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 1.493e-09 0.53
NEK9_HUMAN NEK9 Serine/threonine-protein kinase Nek9 1.557e-09 0.34
MK03_HUMAN MAPK3 Mitogen-activated protein kinase 3 1.847e-09 0.37
EPHA5_HUMAN EPHA5 Ephrin type-A receptor 5 2.183e-09 0.34
CLK2_HUMAN CLK2 Dual specificity protein kinase CLK2 3.676e-09 0.42
CDKL5_HUMAN CDKL5 Cyclin-dependent kinase-like 5 4.818e-09 0.34
MYO3A_HUMAN MYO3A Myosin-IIIa 4.818e-09 0.34
TAOK2_HUMAN TAOK2 Serine/threonine-protein kinase TAO2 5.209e-09 0.34
M3K20_HUMAN MAP3K20 Mitogen-activated protein kinase kinase kinase 20 6.39e-09 0.53
Q33BM1_RAT Gpr35 G protein-coupled receptor GPR35 9.506e-09 0.28
SGPL1_HUMAN SGPL1 Sphingosine-1-phosphate lyase 1 9.961e-09 0.29
ST17A_HUMAN STK17A Serine/threonine-protein kinase 17A 1.034e-08 0.42
EPHA4_HUMAN EPHA4 Ephrin type-A receptor 4 1.139e-08 0.34
STK3_HUMAN STK3 Serine/threonine-protein kinase 3 1.177e-08 0.41
CD11A_HUMAN CDK11A Cyclin-dependent kinase 11A 1.29e-08 0.34
CDK13_HUMAN CDK13 Cyclin-dependent kinase 13 1.29e-08 0.34
MRCKB_HUMAN CDC42BPB Serine/threonine-protein kinase MRCK beta 1.29e-08 0.34
MRCKG_HUMAN CDC42BPG Serine/threonine-protein kinase MRCK gamma 1.29e-08 0.34
CTRO_HUMAN CIT Citron Rho-interacting kinase 1.637e-08 0.34
HIPK3_HUMAN HIPK3 Homeodomain-interacting protein kinase 3 1.637e-08 0.34
HIPK2_HUMAN HIPK2 Homeodomain-interacting protein kinase 2 1.807e-08 0.42
PTK6_HUMAN PTK6 Protein-tyrosine kinase 6 2.207e-08 0.53
KS6A3_HUMAN RPS6KA3 Ribosomal protein S6 kinase alpha-3 2.247e-08 0.42
M4K1_HUMAN MAP4K1 Mitogen-activated protein kinase kinase kinase kinase 1 2.313e-08 0.34
AURKC_HUMAN AURKC Aurora kinase C 2.957e-08 0.53
EPHB1_HUMAN EPHB1 Ephrin type-B receptor 1 3.218e-08 0.34
FER_HUMAN FER Tyrosine-protein kinase Fer 3.54e-08 0.41
EPHA6_HUMAN EPHA6 Ephrin type-A receptor 6 4.411e-08 0.34
NPBW1_HUMAN NPBWR1 Neuropeptides B/W receptor type 1 5.98e-08 0.33
HUNK_HUMAN HUNK Hormonally up-regulated neu tumor-associated kinase 6.656e-08 0.34
CDK8_HUMAN CDK8 Cyclin-dependent kinase 8 6.979e-08 0.34
HIPK1_HUMAN HIPK1 Homeodomain-interacting protein kinase 1 1.051e-07 0.34
TIE1_HUMAN TIE1 Tyrosine-protein kinase receptor Tie-1 1.051e-07 0.34
LYN_HUMAN LYN Tyrosine-protein kinase Lyn 1.086e-07 0.53
CD11B_HUMAN CDK11B Cyclin-dependent kinase 11B 1.33e-07 0.34
E2AK3_HUMAN EIF2AK3 Eukaryotic translation initiation factor 2-alpha kinase 3 1.332e-07 0.45
E2AK4_HUMAN EIF2AK4 eIF-2-alpha kinase GCN2 1.411e-07 0.45
FGFR1_HUMAN FGFR1 Fibroblast growth factor receptor 1 1.714e-07 0.48
IRAK1_HUMAN IRAK1 Interleukin-1 receptor-associated kinase 1 2.446e-07 0.42
CDK18_HUMAN CDK18 Cyclin-dependent kinase 18 2.485e-07 0.34
RIPK4_HUMAN RIPK4 Receptor-interacting serine/threonine-protein kinase 4 4.383e-07 0.34
M4K4_HUMAN MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4 5.095e-07 0.42
THB_RAT Thrb Thyroid hormone receptor beta 6.093e-07 0.29
INSRR_HUMAN INSRR Insulin receptor-related protein 7.359e-07 0.34
M3K4_HUMAN MAP3K4 Mitogen-activated protein kinase kinase kinase 4 7.359e-07 0.34
TGFR2_HUMAN TGFBR2 TGF-beta receptor type-2 7.427e-07 0.53
TOPK_HUMAN PBK Lymphokine-activated killer T-cell-originated protein kinase 8.658e-07 0.42
FES_HUMAN FES Tyrosine-protein kinase Fes/Fps 9.141e-07 0.36
FRK_HUMAN FRK Tyrosine-protein kinase FRK 9.481e-07 0.53
ACRO_HUMAN ACR Acrosin 1.016e-06 0.30
BMR1B_HUMAN BMPR1B Bone morphogenetic protein receptor type-1B 1.053e-06 0.53
DUSTY_HUMAN DSTYK Dual serine/threonine and tyrosine protein kinase 1.184e-06 0.34
EPHA3_HUMAN EPHA3 Ephrin type-A receptor 3 1.215e-06 0.34
KPCD3_HUMAN PRKD3 Serine/threonine-protein kinase D3 1.623e-06 0.38
M3K13_HUMAN MAP3K13 Mitogen-activated protein kinase kinase kinase 13 1.835e-06 0.34
PLK4_HUMAN PLK4 Serine/threonine-protein kinase PLK4 2.157e-06 0.53
DDR1_HUMAN DDR1 Epithelial discoidin domain-containing receptor 1 2.276e-06 0.53
AGP1_YEAST AGP1 General amino acid permease AGP1 2.614e-06 0.31
ANKK1_HUMAN ANKK1 Ankyrin repeat and protein kinase domain-containing protein 1 2.753e-06 0.34
STK35_HUMAN STK35 Serine/threonine-protein kinase 35 2.753e-06 0.34
MINK1_HUMAN MINK1 Misshapen-like kinase 1 3.109e-06 0.53
STK33_HUMAN STK33 Serine/threonine-protein kinase 33 3.31e-06 0.34
STK25_HUMAN STK25 Serine/threonine-protein kinase 25 4.012e-06 0.34
LUCI_AQULA Luciferin 4-monooxygenase 4.687e-06 0.30
PRIO_HUMAN PRNP Major prion protein 5.239e-06 0.34
NR1H4_MOUSE Nr1h4 Bile acid receptor 5.252e-06 0.28
KKCC1_HUMAN CAMKK1 Calcium/calmodulin-dependent protein kinase kinase 1 5.698e-06 0.34
ULK3_HUMAN ULK3 Serine/threonine-protein kinase ULK3 5.698e-06 0.34
KC1G3_HUMAN CSNK1G3 Casein kinase I isoform gamma-3 6.789e-06 0.32
BLK_HUMAN BLK Tyrosine-protein kinase Blk 7.987e-06 0.53
GRM4_HUMAN GRM4 Metabotropic glutamate receptor 4 8.787e-06 0.31
CDK5_HUMAN CDK5 Cyclin-dependent-like kinase 5 8.848e-06 0.42
TNIK_HUMAN TNIK TRAF2 and NCK-interacting protein kinase 9.26e-06 0.53
SLK_HUMAN SLK STE20-like serine/threonine-protein kinase 9.416e-06 0.53
DYRK3_HUMAN DYRK3 Dual specificity tyrosine-phosphorylation-regulated kinase 3 9.749e-06 0.41

Tropisetron

5HT3A_HUMAN HTR3A 5-hydroxytryptamine receptor 3A 1.746e-95 1.00
5HT3B_RAT Htr3b 5-hydroxytryptamine receptor 3B 6.683e-59 1.00
ACHA7_MOUSE Chrna7 Neuronal acetylcholine receptor subunit alpha-7 1.837e-55 1.00
5HT3A_RAT Htr3a 5-hydroxytryptamine receptor 3A 2.207e-49 1.00
ACHA7_RAT Chrna7 Neuronal acetylcholine receptor subunit alpha-7 2.846e-27 1.00
5HT4R_RAT Htr4 5-hydroxytryptamine receptor 4 1.502e-24 1.00
5HT4R_CAVPO HTR4 5-hydroxytryptamine receptor 4 2.596e-18 1.00
5HT4R_HUMAN HTR4 5-hydroxytryptamine receptor 4 1.28e-17 1.00
SC6A4_HUMAN SLC6A4 Sodium-dependent serotonin transporter 6.793e-13 1.00
5HT3A_CAVPO HTR3A 5-hydroxytryptamine receptor 3A 1.001e-11 1.00
ACHA7_HUMAN CHRNA7 Neuronal acetylcholine receptor subunit alpha-7 1.35e-08 1.00
ACM5_HUMAN CHRM5 Muscarinic acetylcholine receptor M5 2.319e-07 1.00
5HT1A_HUMAN HTR1A 5-hydroxytryptamine receptor 1A 5.355e-05 1.00
ACHB4_HUMAN CHRNB4 Neuronal acetylcholine receptor subunit beta-4 7.978e-05 1.00
GLRA1_RAT Glra1 Glycine receptor subunit alpha-1 1.61e-128 0.58
SC6A3_BOVIN SLC6A3 Sodium-dependent dopamine transporter 9.86e-80 0.37
Q8WSF8_APLCA Soluble acetylcholine receptor 9.164e-71 0.60
SC6A3_RAT Slc6a3 Sodium-dependent dopamine transporter 2.164e-70 0.60
GBRA1_RAT Gabra1 Gamma-aminobutyric acid receptor subunit alpha-1 1.235e-56 0.41
GBRB2_RAT Gabrb2 Gamma-aminobutyric acid receptor subunit beta-2 1.404e-55 0.41
GASR_MOUSE Cckbr Gastrin/cholecystokinin type B receptor 1.092e-51 0.34
GBRG2_RAT Gabrg2 Gamma-aminobutyric acid receptor subunit gamma-2 2.208e-51 0.41
GBRA2_RAT Gabra2 Gamma-aminobutyric acid receptor subunit alpha-2 1.057e-49 0.41
ACHP_LYMST Acetylcholine-binding protein 1.057e-47 0.60
5HT4R_MOUSE Htr4 5-hydroxytryptamine receptor 4 2.287e-46 0.29
GBRA5_RAT Gabra5 Gamma-aminobutyric acid receptor subunit alpha-5 1.535e-44 0.41
GBRB3_RAT Gabrb3 Gamma-aminobutyric acid receptor subunit beta-3 6.741e-44 0.41
ACM1_RAT Chrm1 Muscarinic acetylcholine receptor M1 1.131e-42 0.47
GSTT1_RAT Gstt1 Glutathione S-transferase theta-1 5.166e-42 0.33
KI20A_HUMAN KIF20A Kinesin-like protein KIF20A 5.904e-40 0.33
EDNRA_PIG EDNRA Endothelin-1 receptor 8.542e-39 0.32
Q9WTR4_RAT Slc6a2 Transporter 4.916e-38 0.40
NMBR_HUMAN NMBR Neuromedin-B receptor 2.34e-37 0.32
SC6A3_MACFA SLC6A3 Sodium-dependent dopamine transporter 3.833e-34 0.37
ACM3_RAT Chrm3 Muscarinic acetylcholine receptor M3 1.484e-33 0.47
ACM1_DROME mAChR-A Muscarinic acetylcholine receptor DM1 8.721e-33 0.46
CCKAR_RAT Cckar Cholecystokinin receptor type A 5.578e-32 0.34
CFTR_HUMAN CFTR Cystic fibrosis transmembrane conductance regulator 2.436e-31 0.38
ACM2_RAT Chrm2 Muscarinic acetylcholine receptor M2 1.285e-30 0.47
V1AR_MOUSE Avpr1a Vasopressin V1a receptor 1.492e-30 0.35
SC6A4_RAT Slc6a4 Sodium-dependent serotonin transporter 2.567e-29 0.42
Q5NGQ3_FRATT fabI Enoyl-[acyl-carrier-protein] reductase [NADH] 3.235e-27 0.37
GBRB1_HUMAN GABRB1 Gamma-aminobutyric acid receptor subunit beta-1 2.027e-25 0.34
GBRA3_RAT Gabra3 Gamma-aminobutyric acid receptor subunit alpha-3 3.287e-25 0.35
Q8VH27_CAVPO GPM2 Muscarinic acetylcholine receptor 5.279e-25 0.43
CP125_MYCTU cyp125 Steroid C26-monooxygenase 1.685e-24 0.30
KPCB_MOUSE Prkcb Protein kinase C beta type 1.348e-23 0.29
SC6A3_HUMAN SLC6A3 Sodium-dependent dopamine transporter 1.271e-21 0.43
ADA1B_RAT Adra1b Alpha-1B adrenergic receptor 2.338e-21 0.41
JUN_HUMAN JUN Transcription factor AP-1 1.222e-20 0.32
GASR_RAT Cckbr Gastrin/cholecystokinin type B receptor 7.375e-20 0.32
ACM5_RAT Chrm5 Muscarinic acetylcholine receptor M5 5.236e-19 0.47
S15A2_RAT Slc15a2 Solute carrier family 15 member 2 1.851e-18 0.34
ACM3_HUMAN CHRM3 Muscarinic acetylcholine receptor M3 7.978e-18 0.50
Q6Q253_PIG 5-HT4R 5-hydroxytryptamine receptor 4 protein 8.425e-18 0.49
ECE1_HUMAN ECE1 Endothelin-converting enzyme 1 9.125e-18 0.31
CCR2_HUMAN CCR2 C-C chemokine receptor type 2 9.456e-18 0.32
5HT3B_HUMAN HTR3B 5-hydroxytryptamine receptor 3B 1.015e-17 0.34
ACM2_HUMAN CHRM2 Muscarinic acetylcholine receptor M2 1.85e-17 0.50
HES1_MOUSE Hes1 Transcription factor HES-1 1.11e-16 0.32
ACM1_HUMAN CHRM1 Muscarinic acetylcholine receptor M1 2.22e-16 0.50
NEP_RABIT MME Neprilysin 4.441e-16 0.31
NK1R_MOUSE Tacr1 Substance-P receptor 1.665e-15 0.29
SIA4A_HUMAN ST3GAL1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 2.776e-15 0.29
DNMT1_MOUSE Dnmt1 DNA (cytosine-5)-methyltransferase 1 7.438e-15 0.28
ACM4_RAT Chrm4 Muscarinic acetylcholine receptor M4 5.185e-14 0.47
VATB1_HUMAN ATP6V1B1 V-type proton ATPase subunit B, kidney isoform 5.473e-14 0.31
VPP1_CHICK ATP6V0A1 V-type proton ATPase 116 kDa subunit a isoform 1 5.473e-14 0.31
GBRB2_HUMAN GABRB2 Gamma-aminobutyric acid receptor subunit beta-2 1.382e-13 0.36
MSHR_MOUSE Mc1r Melanocyte-stimulating hormone receptor 1.703e-13 0.35
NMDE2_RAT Grin2b Glutamate receptor ionotropic, NMDA 2B 2.542e-13 0.41
5HT1F_HUMAN HTR1F 5-hydroxytryptamine receptor 1F 1.615e-12 0.31
NCOR2_HUMAN NCOR2 Nuclear receptor corepressor 2 2.968e-12 0.30
CCKAR_MOUSE Cckar Cholecystokinin receptor type A 3.589e-12 0.34
ACE_RAT Ace Angiotensin-converting enzyme 1.097e-11 0.31
NK1R_CAVPO TACR1 Substance-P receptor 1.996e-11 0.36
Q8WMX0_BOVIN Muscarinic receptor M1 2.182e-11 0.47
SSR3_HUMAN SSTR3 Somatostatin receptor type 3 2.246e-11 0.32
ADA1A_RAT Adra1a Alpha-1A adrenergic receptor 6.81e-11 0.41
GBRA6_HUMAN GABRA6 Gamma-aminobutyric acid receptor subunit alpha-6 9.446e-11 0.28
MTSI_SPISQ sssIM CPG DNA methylase 9.837e-11 0.34
SC6A2_HUMAN SLC6A2 Sodium-dependent noradrenaline transporter 1.353e-10 0.43
JAK3_MOUSE Jak3 Tyrosine-protein kinase JAK3 1.635e-10 0.31
PPIB_HUMAN PPIB Peptidyl-prolyl cis-trans isomerase B 1.675e-10 0.28
GBRA1_HUMAN GABRA1 Gamma-aminobutyric acid receptor subunit alpha-1 1.974e-10 0.36
KPCL_HUMAN PRKCH Protein kinase C eta type 2.292e-10 0.36
ACM2_MOUSE Chrm2 Muscarinic acetylcholine receptor M2 7.132e-10 0.47
ACE_HUMAN ACE Angiotensin-converting enzyme 1.154e-09 0.31
ECE1_RAT Ece1 Endothelin-converting enzyme 1 2.388e-09 0.32
ACHA9_RAT Chrna9 Neuronal acetylcholine receptor subunit alpha-9 4.316e-09 0.28
NK1R_HUMAN TACR1 Substance-P receptor 4.639e-09 0.36
DRD2_RAT Drd2 D(2) dopamine receptor 1.724e-08 0.38
GBRG2_HUMAN GABRG2 Gamma-aminobutyric acid receptor subunit gamma-2 1.864e-08 0.36
GHSR_HUMAN GHSR Growth hormone secretagogue receptor type 1 2.231e-08 0.33
5HT1B_HUMAN HTR1B 5-hydroxytryptamine receptor 1B 4.659e-08 0.31
NMT_PLAF7 Glycylpeptide N-tetradecanoyltransferase 5.65e-08 0.33
KPCE_HUMAN PRKCE Protein kinase C epsilon type 6.642e-08 0.36
CP51_TRYCC CYP51 Sterol 14-alpha demethylase 6.819e-08 0.30
SGMR1_HUMAN SIGMAR1 Sigma non-opioid intracellular receptor 1 7.027e-08 0.41
ANDR_MOUSE Ar Androgen receptor 8.062e-08 0.34
MK09_HUMAN MAPK9 Mitogen-activated protein kinase 9 9.903e-08 0.32
PABP1_HUMAN PABPC1 Polyadenylate-binding protein 1 1.211e-07 0.36
SSR4_HUMAN SSTR4 Somatostatin receptor type 4 1.432e-07 0.30
5HT1D_RAT Htr1d 5-hydroxytryptamine receptor 1D 1.609e-07 0.32
Q8VH26_CAVPO GPM3 Muscarinic acetylcholine receptor 1.689e-07 0.47
5HT1A_RAT Htr1a 5-hydroxytryptamine receptor 1A 2.418e-07 0.39
5HT1D_HUMAN HTR1D 5-hydroxytryptamine receptor 1D 4.638e-07 0.31
GBRA3_HUMAN GABRA3 Gamma-aminobutyric acid receptor subunit alpha-3 5.27e-07 0.34
THER_BACTH npr Thermolysin 6.523e-07 0.29
SC6A4_MACMU SLC6A4 Sodium-dependent serotonin transporter 1.107e-06 0.28
MDHM_PIG MDH2 Malate dehydrogenase, mitochondrial 1.166e-06 0.28
MRP2_RAT Abcc2 Canalicular multispecific organic anion transporter 1 1.277e-06 0.29
ACM4_HUMAN CHRM4 Muscarinic acetylcholine receptor M4 1.789e-06 0.50
TBB1_HUMAN TUBB1 Tubulin beta-1 chain 1.915e-06 0.32
GPR84_HUMAN GPR84 G-protein coupled receptor 84 2.355e-06 0.50
CCKAR_CAVPO CCKAR Cholecystokinin receptor type A 3.93e-06 0.34
GBRA4_HUMAN GABRA4 Gamma-aminobutyric acid receptor subunit alpha-4 4.364e-06 0.28
V1AR_HUMAN AVPR1A Vasopressin V1a receptor 4.498e-06 0.35
MBTD1_HUMAN MBTD1 MBT domain-containing protein 1 4.596e-06 0.29
NK3R_RAT Tacr3 Neuromedin-K receptor 4.647e-06 0.29
STS_HUMAN STS Steryl-sulfatase 4.748e-06 0.32
IF4A3_HUMAN EIF4A3 Eukaryotic initiation factor 4A-III 5.981e-06 0.35
S22A2_HUMAN SLC22A2 Solute carrier family 22 member 2 6.057e-06 0.34
NK2R_MESAU TACR2 Substance-K receptor 8.57e-06 0.29
T23O_MOUSE Tdo2 Tryptophan 2,3-dioxygenase 8.755e-06 0.28

Capivasertib

AKT3_HUMAN AKT3 RAC-gamma serine/threonine-protein kinase 1.756e-90 1.00
AKT2_HUMAN AKT2 RAC-beta serine/threonine-protein kinase 3.879e-80 1.00
AKT1_HUMAN AKT1 RAC-alpha serine/threonine-protein kinase 3.607e-47 1.00
ROCK2_HUMAN ROCK2 Rho-associated protein kinase 2 4.036e-26 1.00
ROCK1_HUMAN ROCK1 Rho-associated protein kinase 1 0.004817 1.00
JAK3_HUMAN JAK3 Tyrosine-protein kinase JAK3 7.59e-71 0.51
JAK2_HUMAN JAK2 Tyrosine-protein kinase JAK2 7.657e-43 0.51
AKTS1_HUMAN AKT1S1 Proline-rich AKT1 substrate 1 1.262e-40 0.37
JAK3_RAT Jak3 Tyrosine-protein kinase JAK3 1.52e-40 0.32
JAK1_HUMAN JAK1 Tyrosine-protein kinase JAK1 7.539e-38 0.45
AATC_HUMAN GOT1 Aspartate aminotransferase, cytoplasmic 1.097e-35 0.28
KS6B1_HUMAN RPS6KB1 Ribosomal protein S6 kinase beta-1 8.311e-23 0.75
LIMK2_HUMAN LIMK2 LIM domain kinase 2 1.669e-21 0.49
MP2K7_HUMAN MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 4.23e-21 0.32
JAK2_MOUSE Jak2 Tyrosine-protein kinase JAK2 4.176e-13 0.32
JAK3_MOUSE Jak3 Tyrosine-protein kinase JAK3 5.566e-11 0.32
LIMK1_HUMAN LIMK1 LIM domain kinase 1 1.717e-09 0.49
DOT1L_HUMAN DOT1L Histone-lysine N-methyltransferase, H3 lysine-79 specific 2.184e-09 0.31
UR2R_HUMAN UTS2R Urotensin-2 receptor 3.553e-08 0.34
TYK2_HUMAN TYK2 Non-receptor tyrosine-protein kinase TYK2 1.343e-07 0.35
HD_HUMAN HTT Huntingtin 1.394e-07 0.31

Revefenacin

ACM3_HUMAN CHRM3 Muscarinic acetylcholine receptor M3 2.377e-83 1.00
ACM2_HUMAN CHRM2 Muscarinic acetylcholine receptor M2 1.714e-09 1.00
ACKR3_HUMAN ACKR3 Atypical chemokine receptor 3 9.112e-92 0.34
ACES_MOUSE Ache Acetylcholinesterase 1.632e-69 0.44
ADRB2_HUMAN ADRB2 Beta-2 adrenergic receptor 1.102e-55 0.58
HGFA_HUMAN HGFAC Hepatocyte growth factor activator 8.611e-45 0.32
CCR3_HUMAN CCR3 C-C chemokine receptor type 3 7.085e-42 0.41
PAQR1_HUMAN ADIPOR1 Adiponectin receptor protein 1 5.06e-41 0.33
PAQR2_HUMAN ADIPOR2 Adiponectin receptor protein 2 5.06e-41 0.33
UR2R_MACMU UTS2R Urotensin-2 receptor 4.932e-38 0.30
UR2R_HUMAN UTS2R Urotensin-2 receptor 1.603e-34 0.38
MTLR_HUMAN MLNR Motilin receptor 3.231e-34 0.33
TF7L2_HUMAN TCF7L2 Transcription factor 7-like 2 3.099e-32 0.33
CTNB1_HUMAN CTNNB1 Catenin beta-1 9.952e-30 0.33
SGMR1_MOUSE Sigmar1 Sigma non-opioid intracellular receptor 1 2.038e-28 0.35
HEPS_HUMAN HPN Serine protease hepsin 3.076e-27 0.32
DRD2_MOUSE Drd2 D(2) dopamine receptor 3.572e-27 0.35
CP2J2_HUMAN CYP2J2 Cytochrome P450 2J2 1.773e-26 0.29
CAC1G_HUMAN CACNA1G Voltage-dependent T-type calcium channel subunit alpha-1G 7.161e-26 0.34
LKHA4_HUMAN LTA4H Leukotriene A-4 hydrolase 1.683e-25 0.39
MCHR1_HUMAN MCHR1 Melanin-concentrating hormone receptor 1 4.538e-24 0.41
MCHR1_MOUSE Mchr1 Melanin-concentrating hormone receptor 1 1.355e-23 0.34
EHMT2_MOUSE Ehmt2 Histone-lysine N-methyltransferase EHMT2 3.817e-23 0.28
SGMR1_HUMAN SIGMAR1 Sigma non-opioid intracellular receptor 1 1.029e-22 0.35
MBTP1_HUMAN MBTPS1 Membrane-bound transcription factor site-1 protease 1.196e-22 0.35
S1PR5_HUMAN S1PR5 Sphingosine 1-phosphate receptor 5 2.392e-22 0.35
ACES_RAT Ache Acetylcholinesterase 3.157e-20 0.40
HRH1_CAVPO HRH1 Histamine H1 receptor 6.854e-20 0.34
ACES_HUMAN ACHE Acetylcholinesterase 1.212e-18 0.44
ANM6_HUMAN PRMT6 Protein arginine N-methyltransferase 6 2.373e-18 0.37
DRD4_HUMAN DRD4 D(4) dopamine receptor 3.769e-18 0.35
ACES_ELEEL ache Acetylcholinesterase 5.583e-18 0.36
5HT7R_HUMAN HTR7 5-hydroxytryptamine receptor 7 2.883e-17 0.34
HRH3_CAVPO HRH3 Histamine H3 receptor 3.844e-17 0.39
MRGX1_RAT Mrgprx1 Mas-related G-protein coupled receptor member X1 1.11e-16 0.31
PD1L1_HUMAN CD274 Programmed cell death 1 ligand 1 2.22e-16 0.38
HRH3_HUMAN HRH3 Histamine H3 receptor 3.331e-16 0.41
LKHA4_MOUSE Lta4h Leukotriene A-4 hydrolase 6.661e-16 0.36
PARP1_MOUSE Parp1 Poly [ADP-ribose] polymerase 1 9.992e-16 0.30
NPFF2_HUMAN NPFFR2 Neuropeptide FF receptor 2 1.554e-15 0.33
5HT4R_RAT Htr4 5-hydroxytryptamine receptor 4 2.22e-15 0.34
MCHR1_RAT Mchr1 Melanin-concentrating hormone receptor 1 2.22e-15 0.33
CARM1_HUMAN CARM1 Histone-arginine methyltransferase CARM1 2.665e-15 0.37
ST14_HUMAN ST14 Suppressor of tumorigenicity 14 protein 5.995e-15 0.32
CHLE_HUMAN BCHE Cholinesterase 1.665e-14 0.33
AKT2_HUMAN AKT2 RAC-beta serine/threonine-protein kinase 1.976e-14 0.40
VACHT_HUMAN SLC18A3 Vesicular acetylcholine transporter 2.354e-14 0.31
AGTR1_PIG AGTR1 Type-1 angiotensin II receptor 4.985e-14 0.31
CCR8_HUMAN CCR8 C-C chemokine receptor type 8 1.023e-13 0.36
NPFF1_HUMAN NPFFR1 Neuropeptide FF receptor 1 2.007e-13 0.31
CCR5_HUMAN CCR5 C-C chemokine receptor type 5 2.706e-13 0.33
OPRX_MOUSE Oprl1 Nociceptin receptor 3.922e-13 0.29
CHLE_HORSE BCHE Cholinesterase 7.009e-13 0.36
SGMR1_CAVPO SIGMAR1 Sigma non-opioid intracellular receptor 1 7.671e-13 0.35
NK2R_HUMAN TACR2 Substance-K receptor 1.163e-12 0.33
LPAR5_HUMAN LPAR5 Lysophosphatidic acid receptor 5 3.853e-12 0.31
SGMR1_RAT Sigmar1 Sigma non-opioid intracellular receptor 1 4.273e-12 0.38
AUKBB_XENLA aurkb-b Aurora kinase B-B 6.651e-12 0.29
VMAT2_MOUSE Slc18a2 Synaptic vesicular amine transporter 1.119e-11 0.28
DCNL1_HUMAN DCUN1D1 DCN1-like protein 1 1.334e-11 0.29
DRD2_HUMAN DRD2 D(2) dopamine receptor 3.735e-11 0.35
KCNJ3_RAT Kcnj3 G protein-activated inward rectifier potassium channel 1 9.166e-11 0.32
KCNJ5_RAT Kcnj5 G protein-activated inward rectifier potassium channel 4 9.166e-11 0.32
LPXC_ECOLI lpxC UDP-3-O-acyl-N-acetylglucosamine deacetylase 2.482e-10 0.31
5HT2C_RAT Htr2c 5-hydroxytryptamine receptor 2C 2.563e-10 0.36
OPRD_HUMAN OPRD1 Delta-type opioid receptor 4.937e-10 0.40
SC5A7_HUMAN SLC5A7 High affinity choline transporter 1 5.43e-10 0.33
FAAH1_HUMAN FAAH Fatty-acid amide hydrolase 1 5.956e-10 0.32
AKT1_HUMAN AKT1 RAC-alpha serine/threonine-protein kinase 7.09e-10 0.40
5HT2A_RAT Htr2a 5-hydroxytryptamine receptor 2A 1.055e-09 0.38
CCKAR_MOUSE Cckar Cholecystokinin receptor type A 1.354e-09 0.29
5HT4R_HUMAN HTR4 5-hydroxytryptamine receptor 4 1.45e-09 0.31
Q9JKC1_RAT Bche Carboxylic ester hydrolase 1.835e-09 0.30
G3H407_CRIGR PROKR2 2.663e-09 0.29
LPAR1_HUMAN LPAR1 Lysophosphatidic acid receptor 1 2.969e-09 0.31
Q2XUH7_PIG Angiotensin type II receptor 3.224e-09 0.28
HRH2_RAT Hrh2 Histamine H2 receptor 6.243e-09 0.29
Q8WSF8_APLCA Soluble acetylcholine receptor 6.304e-09 0.29
5HT7R_CAVPO HTR7 5-hydroxytryptamine receptor 7 6.608e-09 0.30
ACM3_RAT Chrm3 Muscarinic acetylcholine receptor M3 9.472e-09 0.37
WNK1_HUMAN WNK1 Serine/threonine-protein kinase WNK1 1.189e-08 0.31
ANM8_HUMAN PRMT8 Protein arginine N-methyltransferase 8 1.579e-08 0.30
Q8VH26_CAVPO GPM3 Muscarinic acetylcholine receptor 2.315e-08 0.38
DRD2_RAT Drd2 D(2) dopamine receptor 2.446e-08 0.38
MALT1_HUMAN MALT1 Mucosa-associated lymphoid tissue lymphoma translocation protein 1 6.834e-08 0.32
5HT1F_HUMAN HTR1F 5-hydroxytryptamine receptor 1F 6.86e-08 0.29
SCN4A_HUMAN SCN4A Sodium channel protein type 4 subunit alpha 7.256e-08 0.34
ITA4_HUMAN ITGA4 Integrin alpha-4 7.44e-08 0.33
VMAT2_HUMAN SLC18A2 Synaptic vesicular amine transporter 1.129e-07 0.28
S1PR3_HUMAN S1PR3 Sphingosine 1-phosphate receptor 3 1.247e-07 0.35
MRGX1_HUMAN MRGPRX1 Mas-related G-protein coupled receptor member X1 1.351e-07 0.31
5HT1A_HUMAN HTR1A 5-hydroxytryptamine receptor 1A 1.465e-07 0.34
DRD1_BOVIN DRD1 D(1A) dopamine receptor 1.923e-07 0.30
S1PR1_HUMAN S1PR1 Sphingosine 1-phosphate receptor 1 1.929e-07 0.35
FA10_HUMAN F10 Coagulation factor X 2.775e-07 0.38
O97467_PLAFA ht1 Hexose transporter 1 2.91e-07 0.57
PI2R_HUMAN PTGIR Prostacyclin receptor 3.003e-07 0.40
O61059_LEIME LmGT2 Glucose transporter 3.271e-07 0.57
OPRM_HUMAN OPRM1 Mu-type opioid receptor 3.343e-07 0.38
TNIK_HUMAN TNIK TRAF2 and NCK-interacting protein kinase 4.098e-07 0.30
S1PR4_HUMAN S1PR4 Sphingosine 1-phosphate receptor 4 6.076e-07 0.35
5HT2B_RAT Htr2b 5-hydroxytryptamine receptor 2B 6.838e-07 0.30
SC6A5_HUMAN SLC6A5 Sodium- and chloride-dependent glycine transporter 2 8.051e-07 0.32
NAMPT_MOUSE Nampt Nicotinamide phosphoribosyltransferase 8.676e-07 0.30
HDAC1_HUMAN HDAC1 Histone deacetylase 1 9.478e-07 0.41
TM11D_HUMAN TMPRSS11D Transmembrane protease serine 11D 1.133e-06 0.29
KCNH2_HUMAN KCNH2 Potassium voltage-gated channel subfamily H member 2 2.354e-06 0.37
PDE6D_HUMAN PDE6D Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta 2.678e-06 0.29
PLD1_RAT Pld1 Phospholipase D1 2.965e-06 0.31
DRD3_HUMAN DRD3 D(3) dopamine receptor 3.086e-06 0.35
MBTD1_HUMAN MBTD1 MBT domain-containing protein 1 3.101e-06 0.29
CHK2_HUMAN CHEK2 Serine/threonine-protein kinase Chk2 3.245e-06 0.33
PRIO_SHEEP PRNP Major prion protein 3.531e-06 0.28
GTR1_HUMAN SLC2A1 Solute carrier family 2, facilitated glucose transporter member 1 4.225e-06 0.57
CAC1B_HUMAN CACNA1B Voltage-dependent N-type calcium channel subunit alpha-1B 4.556e-06 0.31
ACM2_RAT Chrm2 Muscarinic acetylcholine receptor M2 4.8e-06 0.37
MTP_HUMAN MTTP Microsomal triglyceride transfer protein large subunit 5.466e-06 0.35
TGFR1_HUMAN TGFBR1 TGF-beta receptor type-1 6.072e-06 0.34
DRD3_RAT Drd3 D(3) dopamine receptor 6.282e-06 0.30
SCN2A_RAT Scn2a Sodium channel protein type 2 subunit alpha 7.297e-06 0.30
ACM4_RAT Chrm4 Muscarinic acetylcholine receptor M4 7.609e-06 0.37
A5A4K8_RABIT MLNR Motilin receptor 9.943e-06 0.29

Difelikefalin

OPRK_MOUSE Oprk1 Kappa-type opioid receptor 7.913e-83 1.00
OPRK_HUMAN OPRK1 Kappa-type opioid receptor 2.129e-21 1.00
OPRM_RAT Oprm1 Mu-type opioid receptor 2.149e-203 0.56
NTR2_HUMAN NTSR2 Neurotensin receptor type 2 1.314e-197 0.48
CAN2_HUMAN CAPN2 Calpain-2 catalytic subunit 5.038e-189 0.42
CDYL2_HUMAN CDYL2 Chromodomain Y-like protein 2 8.329e-175 0.44
OPRD_RAT Oprd1 Delta-type opioid receptor 1.701e-174 0.56
CBX7_HUMAN CBX7 Chromobox protein homolog 7 1.3e-168 0.44
CATB_BOVIN CTSB Cathepsin B 5.158e-165 0.54
OPRD_MOUSE Oprd1 Delta-type opioid receptor 2.405e-158 0.56
CBX4_HUMAN CBX4 E3 SUMO-protein ligase CBX4 1.545e-150 0.44
OPRM_CAVPO OPRM1 Mu-type opioid receptor 4.513e-145 0.56
CBX8_HUMAN CBX8 Chromobox protein homolog 8 3.247e-144 0.44
CD36_RAT Cd36 Platelet glycoprotein 4 3.065e-138 0.42
NTR1_RAT Ntsr1 Neurotensin receptor type 1 2.523e-136 0.46
MC5R_MOUSE Mc5r Melanocortin receptor 5 3.241e-135 0.38
RENI_HUMAN REN Renin 1.859e-128 0.42
NTR1_MOUSE Ntsr1 Neurotensin receptor type 1 2.042e-127 0.44
NTR1_HUMAN NTSR1 Neurotensin receptor type 1 2.185e-127 0.48
HLAA_HUMAN HLA-A HLA class I histocompatibility antigen, A alpha chain 2.337e-126 0.45
MC4R_HUMAN MC4R Melanocortin receptor 4 9.711e-126 0.44
MMP9_RAT Mmp9 Matrix metalloproteinase-9 2.965e-118 0.42
KLK3_HUMAN KLK3 Prostate-specific antigen 4.898e-118 0.47
CAN1_HUMAN CAPN1 Calpain-1 catalytic subunit 2.428e-112 0.49
TIMP3_RAT Timp3 Metalloproteinase inhibitor 3 1.489e-110 0.41
CPNS1_PIG CAPNS1 Calpain small subunit 1 5.738e-108 0.42
GHRHR_RAT Ghrhr Growth hormone-releasing hormone receptor 4.689e-107 0.39
PRSS8_HUMAN PRSS8 Prostasin 1.039e-106 0.39
Q8CGM4_CAVPO OPRM1 Mu-opioid receptor 2.946e-106 0.43
MC4R_MOUSE Mc4r Melanocortin receptor 4 3.664e-105 0.38
MC3R_HUMAN MC3R Melanocortin receptor 3 1.994e-104 0.38
PCSK6_HUMAN PCSK6 Proprotein convertase subtilisin/kexin type 6 7.432e-104 0.40
LSHR_RAT Lhcgr Lutropin-choriogonadotropic hormone receptor 5.543e-103 0.38
POLG_WNV Genome polyprotein 2.592e-100 0.41
MSHR_HUMAN MC1R Melanocyte-stimulating hormone receptor 4.237e-99 0.40
MSHR_MOUSE Mc1r Melanocyte-stimulating hormone receptor 1.57e-97 0.38
ST14_HUMAN ST14 Suppressor of tumorigenicity 14 protein 1.593e-96 0.45
RENI_RAT Ren1 Renin 1.918e-96 0.37
AMD_RAT Pam Peptidylglycine alpha-amidating monooxygenase 1.209e-95 0.35
FPR1_HUMAN FPR1 fMet-Leu-Phe receptor 1.93e-95 0.51
THER_BACTH npr Thermolysin 5.779e-92 0.38
NPFF2_RAT Npffr2 Neuropeptide FF receptor 2 1.354e-91 0.43
NEP_RABIT MME Neprilysin 5.256e-91 0.42
FCER2_HUMAN FCER2 Low affinity immunoglobulin epsilon Fc receptor 8.858e-91 0.36
NK1R_RAT Tacr1 Substance-P receptor 1.717e-90 0.45
QRFPR_HUMAN QRFPR Pyroglutamylated RF-amide peptide receptor 2.01e-90 0.42
ADRM1_HUMAN ADRM1 Proteasomal ubiquitin receptor ADRM1 2.833e-89 0.43
PRS10_HUMAN PSMC6 26S proteasome regulatory subunit 10B 2.833e-89 0.43
PRS4_HUMAN PSMC1 26S proteasome regulatory subunit 4 2.833e-89 0.43
PRS6A_HUMAN PSMC3 26S proteasome regulatory subunit 6A 2.833e-89 0.43
PRS6B_HUMAN PSMC4 26S proteasome regulatory subunit 6B 2.833e-89 0.43
PRS7_HUMAN PSMC2 26S proteasome regulatory subunit 7 2.833e-89 0.43
PRS8_HUMAN PSMC5 26S proteasome regulatory subunit 8 2.833e-89 0.43
PSD11_HUMAN PSMD11 26S proteasome non-ATPase regulatory subunit 11 2.833e-89 0.43
PSD12_HUMAN PSMD12 26S proteasome non-ATPase regulatory subunit 12 2.833e-89 0.43
PSD13_HUMAN PSMD13 26S proteasome non-ATPase regulatory subunit 13 2.833e-89 0.43
PSMD1_HUMAN PSMD1 26S proteasome non-ATPase regulatory subunit 1 2.833e-89 0.43
PSMD2_HUMAN PSMD2 26S proteasome non-ATPase regulatory subunit 2 2.833e-89 0.43
PSMD3_HUMAN PSMD3 26S proteasome non-ATPase regulatory subunit 3 2.833e-89 0.43
PSMD4_HUMAN PSMD4 26S proteasome non-ATPase regulatory subunit 4 2.833e-89 0.43
PSMD6_HUMAN PSMD6 26S proteasome non-ATPase regulatory subunit 6 2.833e-89 0.43
PSMD7_HUMAN PSMD7 26S proteasome non-ATPase regulatory subunit 7 2.833e-89 0.43
PSMD8_HUMAN PSMD8 26S proteasome non-ATPase regulatory subunit 8 2.833e-89 0.43
SEM1_HUMAN SEM1 26S proteasome complex subunit SEM1 2.833e-89 0.43
POLG_DEN26 Genome polyprotein 1.097e-88 0.40
ACE2_HUMAN ACE2 Angiotensin-converting enzyme 2 1.888e-88 0.40
PAR2_HUMAN F2RL1 Proteinase-activated receptor 2 2.908e-85 0.40
NK1R_CAVPO TACR1 Substance-P receptor 4.204e-85 0.45
FURIN_HUMAN FURIN Furin 1.158e-83 0.42
NEP_MOUSE Mme Neprilysin 1.844e-83 0.42
VM1B1_BOTAS Snake venom metalloproteinase BaP1 7.726e-83 0.56
MC3R_MOUSE Mc3r Melanocortin receptor 3 1.601e-82 0.35
GASR_HUMAN CCKBR Gastrin/cholecystokinin type B receptor 1.072e-79 0.43
ST14_MOUSE St14 Suppressor of tumorigenicity 14 protein homolog 4.863e-79 0.34
NK2R_MESAU TACR2 Substance-K receptor 9.544e-79 0.43
CAC1B_HUMAN CACNA1B Voltage-dependent N-type calcium channel subunit alpha-1B 2.768e-77 0.42
NK2R_HUMAN TACR2 Substance-K receptor 8.307e-77 0.41
SYYC_HUMAN YARS1 Tyrosine--tRNA ligase, cytoplasmic 9.238e-77 0.37
NPFF1_HUMAN NPFFR1 Neuropeptide FF receptor 1 9.312e-77 0.39
PAR1_HUMAN F2R Proteinase-activated receptor 1 1.169e-76 0.47
CATB_HUMAN CTSB Cathepsin B 4.059e-76 0.44
NK2R_RAT Tacr2 Substance-K receptor 1.528e-75 0.45
SSR2_HUMAN SSTR2 Somatostatin receptor type 2 5.062e-74 0.39
ACE_HUMAN ACE Angiotensin-converting enzyme 6.341e-74 0.44
PSB8_HUMAN PSMB8 Proteasome subunit beta type-8 7.528e-74 0.43
CCKAR_CAVPO CCKAR Cholecystokinin receptor type A 9.341e-74 0.37
NPFF2_HUMAN NPFFR2 Neuropeptide FF receptor 2 2.52e-73 0.39
SORT_HUMAN SORT1 Sortilin 4.245e-73 0.39
MMP8_RAT Mmp8 Neutrophil collagenase 7.184e-73 0.42
TRY2_BOVIN Anionic trypsin 8.649e-73 0.35
MMP3_HUMAN MMP3 Stromelysin-1 1.178e-71 0.44
PSB2_HUMAN PSMB2 Proteasome subunit beta type-2 1.203e-71 0.43
HEPS_HUMAN HPN Serine protease hepsin 1.537e-71 0.45
LCAP_HUMAN LNPEP Leucyl-cystinyl aminopeptidase 3.086e-71 0.41
SSR2_MOUSE Sstr2 Somatostatin receptor type 2 1.721e-70 0.40
CATL1_HUMAN CTSL Cathepsin L1 1.831e-70 0.55
B3DH72_DANRE oprd1b Opioid receptor, delta 1b 3.216e-70 0.36
O57585_DANRE oprd1a Opioid receptor homologue 3.216e-70 0.36
PSB5_HUMAN PSMB5 Proteasome subunit beta type-5 6.096e-70 0.43
PAPA1_CARPA Papain 1.252e-69 0.42
CYSP_TRYCR Cruzipain 1.897e-69 0.44
KISSR_HUMAN KISS1R KiSS-1 receptor 4.236e-69 0.35
BXA1_CLOBH botA Botulinum neurotoxin type A 6.274e-69 0.42
CAN2_BOVIN CAPN2 Calpain-2 catalytic subunit 7.806e-68 0.42
MBOA4_HUMAN MBOAT4 Ghrelin O-acyltransferase 1.996e-67 0.37
C3AR_HUMAN C3AR1 C3a anaphylatoxin chemotactic receptor 9.532e-67 0.49
AMPB_RAT Rnpep Aminopeptidase B 1.907e-66 0.46
MMP1_HUMAN MMP1 Interstitial collagenase 4.088e-66 0.49
TMPS6_HUMAN TMPRSS6 Transmembrane protease serine 6 6.919e-66 0.39
AMPN_PIG ANPEP Aminopeptidase N 2.535e-65 0.41
HGFA_HUMAN HGFAC Hepatocyte growth factor activator 1.361e-64 0.45
Q95PM0_TRYBR rhodesain Cysteine protease 1.398e-63 0.36
Q98UH1_DANRE oprm1 Mu opioid receptor-like OR2 1.475e-63 0.36
PLMN_BOVIN PLG Plasminogen 3.424e-59 0.42
RIR1_MOUSE Rrm1 Ribonucleoside-diphosphate reductase large subunit 1.362e-57 0.37
Q6MGC4_RAT Pfdn6 H2-K region expressed gene 2, rat orthologue 9.56e-57 0.41
MRGX1_MOUSE Mrgprx1 Mas-related G-protein coupled receptor member X1 2.122e-56 0.37
Q8I6Z5_PLAF7 Plasmepsin V 2.139e-56 0.35
OPRD_HUMAN OPRD1 Delta-type opioid receptor 2.335e-56 0.47
EDNRA_MOUSE Ednra Endothelin-1 receptor 2.55e-56 0.36
CAN1_PIG CAPN1 Calpain-1 catalytic subunit 4.759e-56 0.40
BRCA1_HUMAN BRCA1 Breast cancer type 1 susceptibility protein 1.624e-55 0.30
PSB9_HUMAN PSMB9 Proteasome subunit beta type-9 4.32e-55 0.43
PEPT1_DERPT DERP1 Peptidase 1 7.588e-55 0.41
PLMN_HUMAN PLG Plasminogen 1.354e-54 0.37
CBX5_HUMAN CBX5 Chromobox protein homolog 5 1.36e-54 0.44
ERAP2_HUMAN ERAP2 Endoplasmic reticulum aminopeptidase 2 6.624e-54 0.41
NEP_RAT Mme Neprilysin 9.801e-53 0.40
OPRK_RAT Oprk1 Kappa-type opioid receptor 1.094e-52 0.47
KLKB1_HUMAN KLKB1 Plasma kallikrein 1.84e-52 0.43
PSB10_HUMAN PSMB10 Proteasome subunit beta type-10 4.155e-52 0.43
S15A1_HUMAN SLC15A1 Solute carrier family 15 member 1 4.983e-52 0.40
CBX2_HUMAN CBX2 Chromobox protein homolog 2 1.31e-51 0.41
CBX6_HUMAN CBX6 Chromobox protein homolog 6 1.31e-51 0.41
CDY1_HUMAN CDY1; CDY1B Testis-specific chromodomain protein Y 1 1.31e-51 0.41
CDYL_HUMAN CDYL Chromodomain Y-like protein 1.31e-51 0.41
AMPB_MOUSE Rnpep Aminopeptidase B 5.927e-51 0.41
AMPL_BOVIN LAP3 Cytosol aminopeptidase 5.927e-51 0.41
POLG_HRV14 Genome polyprotein 3.077e-50 0.40
THRB_BOVIN F2 Prothrombin 3.376e-50 0.42
CATD_BOVIN CTSD Cathepsin D 3.926e-50 0.36
ACE_MOUSE Ace Angiotensin-converting enzyme 5.945e-50 0.42
OPRX_MOUSE Oprl1 Nociceptin receptor 8.334e-50 0.41
O07911_STAAU agrC AgrC 9.268e-50 0.37
AMPN_HUMAN ANPEP Aminopeptidase N 1.082e-49 0.41
EDNRB_RAT Ednrb Endothelin receptor type B 1.478e-48 0.37
PSA1_HUMAN PSMA1 Proteasome subunit alpha type-1 5.074e-48 0.43
PSA2_HUMAN PSMA2 Proteasome subunit alpha type-2 5.074e-48 0.43
PSA3_HUMAN PSMA3 Proteasome subunit alpha type-3 5.074e-48 0.43
PSA4_HUMAN PSMA4 Proteasome subunit alpha type-4 5.074e-48 0.43
PSA5_HUMAN PSMA5 Proteasome subunit alpha type-5 5.074e-48 0.43
PSA6_HUMAN PSMA6 Proteasome subunit alpha type-6 5.074e-48 0.43
PSA7_HUMAN PSMA7 Proteasome subunit alpha type-7 5.074e-48 0.43
PSB11_HUMAN PSMB11 Proteasome subunit beta type-11 5.074e-48 0.43
PSB3_HUMAN PSMB3 Proteasome subunit beta type-3 5.074e-48 0.43
PSB4_HUMAN PSMB4 Proteasome subunit beta type-4 5.074e-48 0.43
PSB6_HUMAN PSMB6 Proteasome subunit beta type-6 5.074e-48 0.43
PSB7_HUMAN PSMB7 Proteasome subunit beta type-7 5.074e-48 0.43
PSMA8_HUMAN PSMA8 Proteasome subunit alpha-type 8 5.074e-48 0.43
NEP_HUMAN MME Neprilysin 6.962e-48 0.39
GRIA1_RAT Gria1 Glutamate receptor 1 1.128e-47 0.31
MYLK_CHICK Mylk Myosin light chain kinase, smooth muscle 1.128e-47 0.43
NK3R_CAVPO TACR3 Neuromedin-K receptor 3.026e-47 0.43
ECE1_HUMAN ECE1 Endothelin-converting enzyme 1 3.223e-47 0.37
Q4U254_9ENTO protease Protease 3.726e-47 0.44
S15A2_RAT Slc15a2 Solute carrier family 15 member 2 9.567e-47 0.39
SHC1_HUMAN SHC1 SHC-transforming protein 1 1.454e-46 0.31
CATB_RAT Ctsb Cathepsin B 1.713e-46 0.34
PSB6_YEAST PRE7 Proteasome subunit beta type-6 2.027e-46 0.37
NK2R_CAVPO TACR2 Substance-K receptor 3.698e-46 0.36
PEPA_PIG PGA Pepsin A 9.507e-46 0.39
Q9ERC0_RAT Npy2r Neuropeptide Y receptor Y2 2.352e-45 0.38
NK3R_RAT Tacr3 Neuromedin-K receptor 3.174e-45 0.45
O68720_YERPE yopH Targeted effector protein 1.629e-44 0.36
CATK_HUMAN CTSK Cathepsin K 2.991e-44 0.41
ACE2_RAT Ace2 Angiotensin-converting enzyme 2 5.797e-44 0.37
CAN2_PIG CAPN2 Calpain-2 catalytic subunit 3.627e-43 0.40
SPLB_STAAU splB Serine protease SplB 5.566e-43 0.34
PSB1_HUMAN PSMB1 Proteasome subunit beta type-1 1.675e-42 0.43
STAT3_HUMAN STAT3 Signal transducer and activator of transcription 3 2.261e-42 0.41
Q9N6S8_PLAFA Cysteine proteinase falcipain 2a 9.803e-42 0.45
CBPA1_HUMAN CPA1 Carboxypeptidase A1 1.135e-41 0.33
GRIA1_HUMAN GRIA1 Glutamate receptor 1 1.387e-41 0.36
Q6IE76_BOVIN FDFT1 FDFT1 protein 1.574e-41 0.33
PSB5_YEAST PRE2 Proteasome subunit beta type-5 3.145e-41 0.37
CTRB_BOVIN Chymotrypsinogen B 4.98e-41 0.30
GSP_CRIFA GSP Glutathionylspermidine synthase 9.474e-41 0.39
PEPC_HUMAN PGC Gastricsin 1.318e-40 0.35
CATL1_RAT Ctsl Cathepsin L1 4.37e-40 0.34
SURA_ECOLI surA Chaperone SurA 7.545e-40 0.32
CATJ_RAT Ctsj Cathepsin J 3.85e-39 0.33
ACE_RAT Ace Angiotensin-converting enzyme 4.577e-39 0.42
G1FEK8_9CALI Protease 4.797e-39 0.31
I1U3K2_9CALI POL Nonstructural polyprotein 4.797e-39 0.31
Q99P97_RAT Histone deacetylase 6 1.007e-38 0.31
AMPN_RAT Anpep Aminopeptidase N 3.704e-38 0.30
ERAP1_HUMAN ERAP1 Endoplasmic reticulum aminopeptidase 1 3.912e-38 0.41
KLK1_HUMAN KLK1 Kallikrein-1 5.56e-38 0.49
OPRK_CAVPO OPRK1 Kappa-type opioid receptor 6.537e-38 0.67
IL2RA_HUMAN IL2RA Interleukin-2 receptor subunit alpha 6.694e-38 0.30
AMP1_PLAFQ M1 family aminopeptidase 9.277e-38 0.41
HMDH_MESAU HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1.055e-37 0.33
STAT1_MOUSE Stat1 Signal transducer and activator of transcription 1 1.917e-37 0.30
SIR1_HUMAN SIRT1 NAD-dependent protein deacetylase sirtuin-1 2.459e-37 0.43
DPP2_HUMAN DPP7 Dipeptidyl peptidase 2 3.965e-37 0.49
CATH_RAT Ctsh Pro-cathepsin H 5.186e-37 0.31
OPRM_MOUSE Oprm1 Mu-type opioid receptor 6.069e-37 0.44
SYL_STAA8 leuS Leucine--tRNA ligase 7.142e-37 0.29
ELAS_PSEAE lasB Elastase 1.097e-36 0.39
MC5R_RAT Mc5r Melanocortin receptor 5 1.775e-36 0.29
ECE1_BOVIN ECE1 Endothelin-converting enzyme 1 1.813e-36 0.31
RIR1_HHV11 RIR1 Ribonucleoside-diphosphate reductase large subunit 2.12e-36 0.38
ANT3_HUMAN SERPINC1 Antithrombin-III 3.875e-36 0.29
SSR5_RAT Sstr5 Somatostatin receptor type 5 7.44e-36 0.29
TGM2_HUMAN TGM2 Protein-glutamine gamma-glutamyltransferase 2 1.715e-35 0.43
GHSR_HUMAN GHSR Growth hormone secretagogue receptor type 1 1.893e-35 0.53
MC5R_HUMAN MC5R Melanocortin receptor 5 7.465e-35 0.38
ACE_RABIT ACE Angiotensin-converting enzyme 8.014e-35 0.44
NEP_PIG MME Neprilysin 9.699e-35 0.39
CFAB_HUMAN CFB Complement factor B 1.642e-34 0.31
CCKAR_MOUSE Cckar Cholecystokinin receptor type A 2.397e-34 0.37
AMD_HUMAN PAM Peptidyl-glycine alpha-amidating monooxygenase 4.35e-34 0.42
BLA1_STEMA Metallo-beta-lactamase L1 type 3 4.728e-34 0.33
DNPEP_HUMAN DNPEP Aspartyl aminopeptidase 1.301e-33 0.34
CALRL_RAT Calcrl Calcitonin gene-related peptide type 1 receptor 3.209e-33 0.40
MMP8_HUMAN MMP8 Neutrophil collagenase 3.781e-33 0.44
NMT_CANAL NMT1 Glycylpeptide N-tetradecanoyltransferase 7.963e-33 0.37
Q91H74_9FLAV Genome polyprotein 1.257e-32 0.39
CATC_RAT Ctsc Dipeptidyl peptidase 1 1.456e-32 0.33
RENI1_MOUSE Ren1 Renin-1 1.77e-32 0.32
MMP2_HUMAN MMP2 72 kDa type IV collagenase 1.367e-31 0.49
EDNRA_PIG EDNRA Endothelin-1 receptor 3.574e-31 0.36
FSHR_RAT Fshr Follicle-stimulating hormone receptor 1.227e-30 0.38
CATL1_BOVIN CTSL Cathepsin L1 2.082e-30 0.33
UROK_HUMAN PLAU Urokinase-type plasminogen activator 6.549e-30 0.37
THRB_HUMAN F2 Prothrombin 1.629e-29 0.45
MMP9_HUMAN MMP9 Matrix metalloproteinase-9 3.54e-29 0.49
EDNRB_PIG EDNRB Endothelin receptor type B 2.19e-28 0.36
OPRM_HUMAN OPRM1 Mu-type opioid receptor 3.902e-28 0.51
S15A2_HUMAN SLC15A2 Solute carrier family 15 member 2 8.697e-28 0.34
NEC1_HUMAN PCSK1 Neuroendocrine convertase 1 8.879e-28 0.32
PCSK5_HUMAN PCSK5 Proprotein convertase subtilisin/kexin type 5 8.879e-28 0.32
STAT6_HUMAN STAT6 Signal transducer and activator of transcription 6 9.942e-28 0.42
AMPL_HUMAN LAP3 Cytosol aminopeptidase 1.012e-27 0.41
CATS_HUMAN CTSS Cathepsin S 2.184e-27 0.41
CATZ_RAT Ctsz Cathepsin Z 1.941e-26 0.33
NMUR1_HUMAN NMUR1 Neuromedin-U receptor 1 2.997e-26 0.42
MRGX1_RAT Mrgprx1 Mas-related G-protein coupled receptor member X1 4.953e-26 0.37
Q72874_9HIV1 pol Pol polyprotein 9.607e-26 0.44
Q9NBD4_PLAFA Cysteine protease falcipain-2 9.886e-26 0.32
PEPA1_PENJA Penicillopepsin-1 1.382e-25 0.29
NPY4R_HUMAN NPY4R Neuropeptide Y receptor type 4 1.651e-25 0.39
CATD_HUMAN CTSD Cathepsin D 1.7e-25 0.39
GNPAT_HUMAN GNPAT Dihydroxyacetone phosphate acyltransferase 2.01e-25 0.41
NK3R_HUMAN TACR3 Neuromedin-K receptor 2.029e-25 0.40
PSDE_HUMAN PSMD14 26S proteasome non-ATPase regulatory subunit 14 2.459e-25 0.43
LCAP_RAT Lnpep Leucyl-cystinyl aminopeptidase 2.903e-25 0.41
C5AR1_HUMAN C5AR1 C5a anaphylatoxin chemotactic receptor 1 3.317e-25 0.44
TRY1_BOVIN Cationic trypsin 6.763e-25 0.38
GHSR_RAT Ghsr Growth hormone secretagogue receptor type 1 2.073e-24 0.42
A5A4K8_RABIT MLNR Motilin receptor 2.141e-24 0.48
NMUR2_HUMAN NMUR2 Neuromedin-U receptor 2 2.347e-24 0.42
FA10_BOVIN F10 Coagulation factor X 4.287e-24 0.34
MMP17_HUMAN MMP17 Matrix metalloproteinase-17 4.874e-24 0.49
SYL_ECOLI leuS Leucine--tRNA ligase 9.719e-24 0.29
AMPB_HUMAN RNPEP Aminopeptidase B 1.074e-23 0.34
PLMN_RAT Plg Plasminogen 1.622e-23 0.51
SSR4_HUMAN SSTR4 Somatostatin receptor type 4 1.67e-23 0.34
GRPR_RAT Grpr Gastrin-releasing peptide receptor 1.827e-23 0.33
O31048_PORGN DPP IV Dipeptidyl peptidase IV 1.89e-23 0.36
CBPB2_HUMAN CPB2 Carboxypeptidase B2 1.971e-23 0.41
CATE_HUMAN CTSE Cathepsin E 2.071e-23 0.32
NMT_YEAST NMT1 Glycylpeptide N-tetradecanoyltransferase 2.206e-23 0.29
MMP7_HUMAN MMP7 Matrilysin 2.414e-23 0.39
CARP_YEAST PEP4 Saccharopepsin 2.847e-23 0.29
SSPA_STAAU sspA Glutamyl endopeptidase 3.349e-23 0.35
SSR1_HUMAN SSTR1 Somatostatin receptor type 1 6.044e-23 0.34
GRB2_HUMAN GRB2 Growth factor receptor-bound protein 2 1.159e-22 0.35
FNTB_RAT Fntb Protein farnesyltransferase subunit beta 1.477e-22 0.45
FNTA_RAT Fnta Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha 2.211e-22 0.45
XIAP_HUMAN XIAP E3 ubiquitin-protein ligase XIAP 2.902e-22 0.49
EDNRA_HUMAN EDNRA Endothelin-1 receptor 3.463e-22 0.40
Q6DMN0_TOXGO CPL Cathepsin L 2.835e-21 0.34
LY96_HUMAN LY96 Lymphocyte antigen 96 3.385e-21 0.41
MCA2_TRYBB MCA2 Metacaspase 4.675e-21 0.33
TETX_CLOTE tetX Tetanus toxin 9.089e-21 0.29
XPP2_RAT Xpnpep2 Xaa-Pro aminopeptidase 2 1.327e-20 0.29
RIR1_MYCTU nrdE Ribonucleoside-diphosphate reductase subunit alpha 1.948e-20 0.33
MMP11_MOUSE Mmp11 Stromelysin-3 4.57e-20 0.31
PEN2_HUMAN PSENEN Gamma-secretase subunit PEN-2 4.889e-20 0.45
APH1A_HUMAN APH1A Gamma-secretase subunit APH-1A 8.955e-20 0.45
APH1B_HUMAN APH1B Gamma-secretase subunit APH-1B 8.955e-20 0.45
NICA_HUMAN NCSTN Nicastrin 8.955e-20 0.45
PSN2_HUMAN PSEN2 Presenilin-2 9.624e-20 0.45
DSBA_ECOLI dsbA Thiol:disulfide interchange protein DsbA 1.498e-19 0.31
STAT3_MOUSE Stat3 Signal transducer and activator of transcription 3 2.103e-19 0.35
GLUT4_HUMAN SLC2A4 Solute carrier family 2, facilitated glucose transporter member 4 3.429e-19 0.30
TRYG1_HUMAN TPSG1 Tryptase gamma 3.691e-19 0.30
PSN1_HUMAN PSEN1 Presenilin-1 5.097e-19 0.45
ANF_HUMAN NPPA Natriuretic peptides A 5.249e-19 0.37
CCNA2_HUMAN CCNA2 Cyclin-A2 6.45e-19 0.49
EPOR_HUMAN EPOR Erythropoietin receptor 1.126e-18 0.30
SIR3_HUMAN SIRT3 NAD-dependent protein deacetylase sirtuin-3, mitochondrial 2.427e-18 0.35
LAT1_HUMAN SLC7A5 Large neutral amino acids transporter small subunit 1 2.749e-18 0.29
AKTS1_HUMAN AKT1S1 Proline-rich AKT1 substrate 1 4.879e-18 0.29
DRB3_HUMAN HLA-DRB3 HLA class II histocompatibility antigen, DR beta 3 chain 5.369e-18 0.32
GNRHR_RAT Gnrhr Gonadotropin-releasing hormone receptor 8.176e-18 0.40
XPP2_HUMAN XPNPEP2 Xaa-Pro aminopeptidase 2 1.375e-17 0.29
AMPX_VIBPR Bacterial leucyl aminopeptidase 2.22e-16 0.41
CATH_HUMAN CTSH Pro-cathepsin H 2.22e-16 0.34
CCR1_HUMAN CCR1 C-C chemokine receptor type 1 3.331e-16 0.40
PSA_HUMAN NPEPPS Puromycin-sensitive aminopeptidase 5.551e-16 0.41
CCKAR_HUMAN CCKAR Cholecystokinin receptor type A 1.11e-15 0.36
CATG_HUMAN CTSG Cathepsin G 3.22e-15 0.38
MC3R_RAT Mc3r Melanocortin receptor 3 3.22e-15 0.29
TRYB1_HUMAN TPSAB1 Tryptase alpha/beta-1 6.328e-15 0.34
PTN1_HUMAN PTPN1 Tyrosine-protein phosphatase non-receptor type 1 6.439e-15 0.38
AMPN_MOUSE Anpep Aminopeptidase N 7.772e-15 0.41
BMP1_HUMAN BMP1 Bone morphogenetic protein 1 8.327e-15 0.33
SSR5_HUMAN SSTR5 Somatostatin receptor type 5 1.643e-14 0.34
ENV_HV1H2 env Envelope glycoprotein gp160 1.787e-14 0.32
AMPE_HUMAN ENPEP Glutamyl aminopeptidase 2.343e-14 0.32
DPP4_MOUSE Dpp4 Dipeptidyl peptidase 4 5.596e-14 0.29
Q94F81_MAIZE hda106 HD2 type histone deacetylase HDA106 8.571e-14 0.31
CCND1_HUMAN CCND1 G1/S-specific cyclin-D1 1.029e-13 0.49
SIR2_HUMAN SIRT2 NAD-dependent protein deacetylase sirtuin-2 1.06e-13 0.40
P2Y12_HUMAN P2RY12 P2Y purinoceptor 12 1.1e-13 0.32
ACHD_HUMAN CHRND Acetylcholine receptor subunit delta 1.108e-13 0.32
SSR3_HUMAN SSTR3 Somatostatin receptor type 3 1.245e-13 0.39
NK1R_HUMAN TACR1 Substance-P receptor 1.361e-13 0.42
BACE1_HUMAN BACE1 Beta-secretase 1 1.72e-13 0.41
XPP1_HUMAN XPNPEP1 Xaa-Pro aminopeptidase 1 2.173e-13 0.29
KEAP1_HUMAN KEAP1 Kelch-like ECH-associated protein 1 2.346e-13 0.37
BKRB1_RAT Bdkrb1 B1 bradykinin receptor 4.474e-13 0.38
HMDH_HUMAN HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase 4.581e-13 0.42
CBPA1_BOVIN CPA1 Carboxypeptidase A1 4.967e-13 0.41
POLG_HCV1 Genome polyprotein 5.861e-13 0.35
NK2R_RABIT TACR2 Substance-K receptor 6.972e-13 0.36
BIRC3_HUMAN BIRC3 Baculoviral IAP repeat-containing protein 3 9.179e-13 0.41
Q9NBA7_PLAFA Cysteine protease falcipain-3 9.976e-13 0.34
KLK5_HUMAN KLK5 Kallikrein-5 1.439e-12 0.32
ITA4_HUMAN ITGA4 Integrin alpha-4 1.925e-12 0.34
CATF_HUMAN CTSF Cathepsin F 2.089e-12 0.30
CP51A_HUMAN CYP51A1 Lanosterol 14-alpha demethylase 3.016e-12 0.33
DPP8_HUMAN DPP8 Dipeptidyl peptidase 8 3.216e-12 0.39
NRP1_RAT Nrp1 Neuropilin-1 3.217e-12 0.30
CEGT_HUMAN UGCG Ceramide glucosyltransferase 3.754e-12 0.38
CEL2A_PIG CELA2A Chymotrypsin-like elastase family member 2A 4.735e-12 0.30
A3EZI9_9HEPC NS3 Genome polyprotein 5.175e-12 0.34
ITB1_HUMAN ITGB1 Integrin beta-1 5.523e-12 0.34
CATK_MOUSE Ctsk Cathepsin K 1.009e-11 0.34
CASP1_HUMAN CASP1 Caspase-1 1.206e-11 0.38
PEPD_HUMAN PEPD Xaa-Pro dipeptidase 1.482e-11 0.28
ECE1_RAT Ece1 Endothelin-converting enzyme 1 2.76e-11 0.30
CCR10_MOUSE Ccr10 C-C chemokine receptor type 10 5.087e-11 0.30
FPRS1_MOUSE Fpr-s1 Formyl peptide receptor-related sequence 1 5.585e-11 0.44
PPCE_PIG PREP Prolyl endopeptidase 5.621e-11 0.38
CATL1_MOUSE Ctsl Cathepsin L1 6.627e-11 0.34
CATS_RAT Ctss Cathepsin S 6.627e-11 0.34
FA12_HUMAN F12 Coagulation factor XII 6.686e-11 0.33
Q79MP6_PSEAI blaIMP-1 Beta-lactamase 6.801e-11 0.29
CALRL_HUMAN CALCRL Calcitonin gene-related peptide type 1 receptor 7.829e-11 0.43
CARP_RHICH Rhizopuspepsin 1.098e-10 0.34
TRY3_HUMAN PRSS3 Trypsin-3 1.105e-10 0.29
TPA_HUMAN PLAT Tissue-type plasminogen activator 1.281e-10 0.34
CATB_MOUSE Ctsb Cathepsin B 3.176e-10 0.34
GSTO1_HUMAN GSTO1 Glutathione S-transferase omega-1 3.548e-10 0.43
Q9NAW4_PLAFA Cysteine protease falcipain-3 4.084e-10 0.29
TPH1_HUMAN TPH1 Tryptophan 5-hydroxylase 1 4.111e-10 0.31
MMP12_HUMAN MMP12 Macrophage metalloelastase 4.282e-10 0.49
Q9YQ12_9HIV1 protease Protease 5.264e-10 0.42
WDR5_HUMAN WDR5 WD repeat-containing protein 5 7.453e-10 0.32
OPRX_HUMAN OPRL1 Nociceptin receptor 9.83e-10 0.43
NTR2_RAT Ntsr2 Neurotensin receptor type 2 2.124e-09 0.39
PRO_HTL1A gag-pro Gag-Pro polyprotein 2.374e-09 0.29
PROC_HUMAN PROC Vitamin K-dependent protein C 2.375e-09 0.30
PEPA5_HUMAN PGA5 Pepsin A-5 3.041e-09 0.31
SPP2A_HUMAN SPPL2A Signal peptide peptidase-like 2A 3.522e-09 0.36
GLNA_HUMAN GLUL Glutamine synthetase 3.598e-09 0.29
R1AB_SARS rep Replicase polyprotein 1ab 3.963e-09 0.31
EDNRA_RAT Ednra Endothelin-1 receptor 4.035e-09 0.32
CTRA_BOVIN Chymotrypsinogen A 6.084e-09 0.31
PGTB1_BOVIN PGGT1B Geranylgeranyl transferase type-1 subunit beta 6.745e-09 0.33
FA10_HUMAN F10 Coagulation factor X 8.034e-09 0.35
SYLC_HUMAN LARS1 Leucine--tRNA ligase, cytoplasmic 9.079e-09 0.29
CTRC_HUMAN CTRC Chymotrypsin-C 1.272e-08 0.34
FNTA_BOVIN FNTA Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha 1.341e-08 0.37
DPP9_HUMAN DPP9 Dipeptidyl peptidase 9 1.343e-08 0.39
IL2RA_MOUSE Il2ra Interleukin-2 receptor subunit alpha 1.709e-08 0.30
CYSK_MYCTU cysK1 O-acetylserine sulfhydrylase 3.103e-08 0.37
CPNS1_HUMAN CAPNS1 Calpain small subunit 1 3.298e-08 0.39
UBC9_HUMAN UBE2I SUMO-conjugating enzyme UBC9 4.315e-08 0.34
CCKAR_RAT Cckar Cholecystokinin receptor type A 4.36e-08 0.38
MRP2_RAT Abcc2 Canalicular multispecific organic anion transporter 1 5.016e-08 0.36
NPY1R_HUMAN NPY1R Neuropeptide Y receptor type 1 5.258e-08 0.34
MMP14_HUMAN MMP14 Matrix metalloproteinase-14 7.88e-08 0.39
FPR2_HUMAN FPR2 N-formyl peptide receptor 2 8.434e-08 0.44
MC4R_RAT Mc4r Melanocortin receptor 4 8.839e-08 0.29
DPO1_THEAQ polA DNA polymerase I, thermostable 1.288e-07 0.29
S6A15_HUMAN SLC6A15 Sodium-dependent neutral amino acid transporter B(0)AT2 1.35e-07 0.28
V1AR_HUMAN AVPR1A Vasopressin V1a receptor 1.37e-07 0.39
NOD2_HUMAN NOD2 Nucleotide-binding oligomerization domain-containing protein 2 1.585e-07 0.33
FA7_HUMAN F7 Coagulation factor VII 2.656e-07 0.36
CBPB1_PIG CPB1 Carboxypeptidase B 3.205e-07 0.29
GASR_MOUSE Cckbr Gastrin/cholecystokinin type B receptor 4.213e-07 0.38
ACPS_BACSU acpS Holo-[acyl-carrier-protein] synthase 4.905e-07 0.29
CBPN_HUMAN CPN1 Carboxypeptidase N catalytic chain 5.365e-07 0.30
D2K2A8_9HEPC NS4A Non-structural protein 4A 5.615e-07 0.32
GP142_MOUSE Gpr142 Probable G-protein coupled receptor 142 5.815e-07 0.28
UR2R_RAT Uts2r Urotensin-2 receptor 5.883e-07 0.42
PTN9_HUMAN PTPN9 Tyrosine-protein phosphatase non-receptor type 9 7.045e-07 0.29
OPRX_CAVPO OPRL1 Nociceptin receptor 8.089e-07 0.31
ITA2B_HUMAN ITGA2B Integrin alpha-IIb 8.352e-07 0.33
TM11D_HUMAN TMPRSS11D Transmembrane protease serine 11D 8.444e-07 0.30
A0A0C7ACN7_PSEAI pqsD 3-oxoacyl-ACP synthase 1.186e-06 0.28
PIN1_HUMAN PIN1 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 1.379e-06 0.32
DPP4_HUMAN DPP4 Dipeptidyl peptidase 4 1.427e-06 0.49
TGM1_HUMAN TGM1 Protein-glutamine gamma-glutamyltransferase K 2.608e-06 0.36
TYRO_HUMAN TYR Tyrosinase 2.862e-06 0.29
GASR_RAT Cckbr Gastrin/cholecystokinin type B receptor 3.174e-06 0.34
FOLH1_HUMAN FOLH1 Glutamate carboxypeptidase 2 3.367e-06 0.34
CDK2_HUMAN CDK2 Cyclin-dependent kinase 2 3.619e-06 0.49
MEN1_HUMAN MEN1 Menin 3.626e-06 0.36
S6A12_MOUSE Slc6a12 Sodium- and chloride-dependent betaine transporter 4.256e-06 0.29
SRC_HUMAN SRC Proto-oncogene tyrosine-protein kinase Src 4.387e-06 0.38
NALD2_HUMAN NAALAD2 N-acetylated-alpha-linked acidic dipeptidase 2 4.687e-06 0.30
CMA1_HUMAN CMA1 Chymase 5.124e-06 0.34
TS1R1_HUMAN TAS1R1 Taste receptor type 1 member 1 5.379e-06 0.28
SIR5_HUMAN SIRT5 NAD-dependent protein deacylase sirtuin-5, mitochondrial 5.393e-06 0.32
KLK7_HUMAN KLK7 Kallikrein-7 6.449e-06 0.32
TF2AA_HUMAN GTF2A1 Transcription initiation factor IIA subunit 1 7.537e-06 0.28
CASP8_HUMAN CASP8 Caspase-8 7.903e-06 0.38
NMBR_HUMAN NMBR Neuromedin-B receptor 8.749e-06 0.30
FNTB_HUMAN FNTB Protein farnesyltransferase subunit beta 9.561e-06 0.41
MMP10_HUMAN MMP10 Stromelysin-2 9.975e-06 0.35

Niraparib

PARP1_HUMAN PARP1 Poly [ADP-ribose] polymerase 1 1.067e-71 1.00
PAR12_HUMAN PARP12 Protein mono-ADP-ribosyltransferase PARP12 1.089e-50 1.00
PARP2_HUMAN PARP2 Poly [ADP-ribose] polymerase 2 4.755e-49 1.00
PARP4_HUMAN PARP4 Protein mono-ADP-ribosyltransferase PARP4 3.41e-39 1.00
PAR14_HUMAN PARP14 Protein mono-ADP-ribosyltransferase PARP14 2.387e-14 1.00
PARP3_HUMAN PARP3 Protein mono-ADP-ribosyltransferase PARP3 7.283e-14 1.00
PAR10_HUMAN PARP10 Protein mono-ADP-ribosyltransferase PARP10 3.747e-13 1.00
TNKS1_HUMAN TNKS Poly [ADP-ribose] polymerase tankyrase-1 0.01141 1.00
TNKS2_HUMAN TNKS2 Poly [ADP-ribose] polymerase tankyrase-2 0.01611 1.00
TAAR1_RAT Taar1 Trace amine-associated receptor 1 1.41e-86 0.42
CDKA1_HUMAN CDK2AP1 Cyclin-dependent kinase 2-associated protein 1 9.133e-64 0.32
TAAR1_MOUSE Taar1 Trace amine-associated receptor 1 1.176e-57 0.42
CHK1_HUMAN CHEK1 Serine/threonine-protein kinase Chk1 6.769e-31 0.35
PARP1_RAT Parp1 Poly [ADP-ribose] polymerase 1 8.3e-30 0.32
TOPK_HUMAN PBK Lymphokine-activated killer T-cell-originated protein kinase 6.259e-23 0.33
KS6B1_HUMAN RPS6KB1 Ribosomal protein S6 kinase beta-1 1.328e-13 0.45
IKKB_HUMAN IKBKB Inhibitor of nuclear factor kappa-B kinase subunit beta 1.901e-10 0.38
O96214_PLAFA pk7 Protein kinase domain-containing protein 3.017e-09 0.28
PDPK1_HUMAN PDPK1 3-phosphoinositide-dependent protein kinase 1 5.742e-07 0.36
IKKB_MOUSE Ikbkb Inhibitor of nuclear factor kappa-B kinase subunit beta 1.304e-06 0.34
PIM3_RAT Pim3 Serine/threonine-protein kinase pim-3 9.475e-06 0.31

Baricitinib

JAK1_HUMAN JAK1 Tyrosine-protein kinase JAK1 2.243e-67 1.00
JAK3_HUMAN JAK3 Tyrosine-protein kinase JAK3 2.901e-63 1.00
JAK2_HUMAN JAK2 Tyrosine-protein kinase JAK2 4.935e-54 1.00
TYK2_HUMAN TYK2 Non-receptor tyrosine-protein kinase TYK2 1.013e-48 1.00
JAK3_RAT Jak3 Tyrosine-protein kinase JAK3 1.551e-39 0.31
VRK2_HUMAN VRK2 Serine/threonine-protein kinase VRK2 9.45e-22 0.49
TNI3K_HUMAN TNNI3K Serine/threonine-protein kinase TNNI3K 5.794e-18 0.31
NEK3_HUMAN NEK3 Serine/threonine-protein kinase Nek3 1.338e-17 0.49
M3K15_HUMAN MAP3K15 Mitogen-activated protein kinase kinase kinase 15 4.885e-15 0.49
ULK3_HUMAN ULK3 Serine/threonine-protein kinase ULK3 4.657e-13 0.49
SYTC_HUMAN TARS1 Threonine--tRNA ligase 1, cytoplasmic 7.13e-13 0.35
SYT_YERPE thrS Threonine--tRNA ligase 7.13e-13 0.35
JAK2_MOUSE Jak2 Tyrosine-protein kinase JAK2 8.579e-13 0.31
DMPK_HUMAN DMPK Myotonin-protein kinase 9.933e-13 0.49
CSKP_HUMAN CASK Peripheral plasma membrane protein CASK 1.413e-12 0.49
MAST1_HUMAN MAST1 Microtubule-associated serine/threonine-protein kinase 1 1.413e-12 0.49
OXSR1_HUMAN OXSR1 Serine/threonine-protein kinase OSR1 1.413e-12 0.49
STK39_HUMAN STK39 STE20/SPS1-related proline-alanine-rich protein kinase 1.413e-12 0.49
DCLK3_HUMAN DCLK3 Serine/threonine-protein kinase DCLK3 3.929e-12 0.49
DCLK2_HUMAN DCLK2 Serine/threonine-protein kinase DCLK2 5.729e-12 0.49
GRK7_HUMAN GRK7 Rhodopsin kinase GRK7 1.328e-11 0.49
NEK7_HUMAN NEK7 Serine/threonine-protein kinase Nek7 1.967e-11 0.49
SBK3_HUMAN SBK3 Uncharacterized serine/threonine-protein kinase SBK3 1.967e-11 0.49
SIK3_HUMAN SIK3 Serine/threonine-protein kinase SIK3 1.967e-11 0.49
TPX2_HUMAN TPX2 Targeting protein for Xklp2 2.335e-11 0.33
BMP2K_HUMAN BMP2K BMP-2-inducible protein kinase 3.938e-11 0.49
KS6A6_HUMAN RPS6KA6 Ribosomal protein S6 kinase alpha-6 3.938e-11 0.49
M3K1_HUMAN MAP3K1 Mitogen-activated protein kinase kinase kinase 1 5.887e-11 0.49
JAK3_MOUSE Jak3 Tyrosine-protein kinase JAK3 1.011e-10 0.31
NUAK2_HUMAN NUAK2 NUAK family SNF1-like kinase 2 1.047e-10 0.49
KCC1D_HUMAN CAMK1D Calcium/calmodulin-dependent protein kinase type 1D 1.052e-10 0.49
KCC1G_HUMAN CAMK1G Calcium/calmodulin-dependent protein kinase type 1G 3.818e-10 0.49
SBK1_HUMAN SBK1 Serine/threonine-protein kinase SBK1 3.818e-10 0.49
PAK6_HUMAN PAK6 Serine/threonine-protein kinase PAK 6 8.54e-10 0.49
RIPK4_HUMAN RIPK4 Receptor-interacting serine/threonine-protein kinase 4 8.54e-10 0.49
ANKK1_HUMAN ANKK1 Ankyrin repeat and protein kinase domain-containing protein 1 1.155e-08 0.49
PAK5_HUMAN PAK5 Serine/threonine-protein kinase PAK 5 1.155e-08 0.49
STK25_HUMAN STK25 Serine/threonine-protein kinase 25 1.969e-08 0.49
RIOK1_HUMAN RIOK1 Serine/threonine-protein kinase RIO1 3.236e-08 0.49
RIOK2_HUMAN RIOK2 Serine/threonine-protein kinase RIO2 3.236e-08 0.49
RIOK3_HUMAN RIOK3 Serine/threonine-protein kinase RIO3 3.236e-08 0.49
KCC2A_HUMAN CAMK2A Calcium/calmodulin-dependent protein kinase type II subunit alpha 4.149e-08 0.49
BMPR2_HUMAN BMPR2 Bone morphogenetic protein receptor type-2 5.146e-08 0.49
SRPK3_HUMAN SRPK3 SRSF protein kinase 3 5.146e-08 0.49
GRK1_HUMAN GRK1 Rhodopsin kinase GRK1 7.948e-08 0.49
GRK4_HUMAN GRK4 G protein-coupled receptor kinase 4 7.948e-08 0.49
ULK1_HUMAN ULK1 Serine/threonine-protein kinase ULK1 1.195e-07 0.49
MP2K3_HUMAN MAP2K3 Dual specificity mitogen-activated protein kinase kinase 3 1.755e-07 0.49
PHKG1_HUMAN PHKG1 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 1.755e-07 0.49
ULK2_HUMAN ULK2 Serine/threonine-protein kinase ULK2 1.755e-07 0.49
M3K3_HUMAN MAP3K3 Mitogen-activated protein kinase kinase kinase 3 2.522e-07 0.49
MP2K4_HUMAN MAP2K4 Dual specificity mitogen-activated protein kinase kinase 4 2.522e-07 0.49
DAPK2_HUMAN DAPK2 Death-associated protein kinase 2 4.913e-07 0.49
TAOK2_HUMAN TAOK2 Serine/threonine-protein kinase TAO2 4.913e-07 0.49
STK16_HUMAN STK16 Serine/threonine-protein kinase 16 6.684e-07 0.49
DAPK1_HUMAN DAPK1 Death-associated protein kinase 1 8.955e-07 0.49
DCLK1_HUMAN DCLK1 Serine/threonine-protein kinase DCLK1 1.008e-06 0.49
PKNB_MYCTU pknB Serine/threonine-protein kinase PknB 1.008e-06 0.49
HIPK3_HUMAN HIPK3 Homeodomain-interacting protein kinase 3 1.183e-06 0.49
M3K2_HUMAN MAP3K2 Mitogen-activated protein kinase kinase kinase 2 1.183e-06 0.49
STK26_HUMAN STK26 Serine/threonine-protein kinase 26 1.183e-06 0.49
BMR1B_HUMAN BMPR1B Bone morphogenetic protein receptor type-1B 3.192e-06 0.49
MP2K2_HUMAN MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 4.104e-06 0.49
HIPK1_HUMAN HIPK1 Homeodomain-interacting protein kinase 1 4.932e-06 0.49
GRK5_HUMAN GRK5 G protein-coupled receptor kinase 5 7.656e-06 0.49
AAK1_HUMAN AAK1 AP2-associated protein kinase 1 8.9e-06 0.49
EPHB6_HUMAN EPHB6 Ephrin type-B receptor 6 8.9e-06 0.49

Infigratinib

FGFR4_HUMAN FGFR4 Fibroblast growth factor receptor 4 2.224e-61 1.00
ALK_HUMAN ALK ALK tyrosine kinase receptor 2.462e-40 1.00
FGFR1_HUMAN FGFR1 Fibroblast growth factor receptor 1 7.512e-30 1.00
FGFR3_HUMAN FGFR3 Fibroblast growth factor receptor 3 2.106e-25 1.00
LCK_HUMAN LCK Tyrosine-protein kinase Lck 2.058e-23 1.00
INSR_HUMAN INSR Insulin receptor 6.574e-21 1.00
EPHB1_HUMAN EPHB1 Ephrin type-B receptor 1 1.11e-16 1.00
FGFR2_HUMAN FGFR2 Fibroblast growth factor receptor 2 1.11e-16 1.00
VGFR2_HUMAN KDR Vascular endothelial growth factor receptor 2 1.11e-16 1.00
FLT3_HUMAN FLT3 Receptor-type tyrosine-protein kinase FLT3 2.22e-16 1.00
BRAF_HUMAN BRAF Serine/threonine-protein kinase B-raf 4.441e-16 1.00
PGFRA_HUMAN PDGFRA Platelet-derived growth factor receptor alpha 3.775e-15 1.00
RON_HUMAN MST1R Macrophage-stimulating protein receptor 2.399e-11 1.00
KIT_HUMAN KIT Mast/stem cell growth factor receptor Kit 8.396e-10 1.00
ROS1_HUMAN ROS1 Proto-oncogene tyrosine-protein kinase ROS 2.709e-09 1.00
NTRK2_HUMAN NTRK2 BDNF/NT-3 growth factors receptor 5.783e-08 1.00
BMX_HUMAN BMX Cytoplasmic tyrosine-protein kinase BMX 6.231e-08 1.00
FYN_HUMAN FYN Tyrosine-protein kinase Fyn 1.693e-07 1.00
VGFR3_HUMAN FLT4 Vascular endothelial growth factor receptor 3 2.651e-07 1.00
YES_HUMAN YES1 Tyrosine-protein kinase Yes 3.486e-07 1.00
RET_HUMAN RET Proto-oncogene tyrosine-protein kinase receptor Ret 6.3e-07 1.00
LYN_HUMAN LYN Tyrosine-protein kinase Lyn 1.797e-06 1.00
SRC_HUMAN SRC Proto-oncogene tyrosine-protein kinase Src 6.055e-06 1.00
VGFR1_HUMAN FLT1 Vascular endothelial growth factor receptor 1 3.511e-05 1.00
TIE2_HUMAN TEK Angiopoietin-1 receptor 0.0001557 1.00
JAK2_HUMAN JAK2 Tyrosine-protein kinase JAK2 0.0001865 1.00
ABL1_HUMAN ABL1 Tyrosine-protein kinase ABL1 0.008281 1.00
TYK2_HUMAN TYK2 Non-receptor tyrosine-protein kinase TYK2 0.01784 1.00
MET_HUMAN MET Hepatocyte growth factor receptor 0.05921 1.00
KSYK_HUMAN SYK Tyrosine-protein kinase SYK 0.1108 1.00
PGFRB_HUMAN PDGFRB Platelet-derived growth factor receptor beta 2.511e-59 0.36
PRIO_SHEEP PRNP Major prion protein 2.484e-37 0.39
ERBB4_HUMAN ERBB4 Receptor tyrosine-protein kinase erbB-4 4.527e-29 0.33
ABL1_MOUSE Abl1 Tyrosine-protein kinase ABL1 4.158e-28 0.37
EGFR_HUMAN EGFR Epidermal growth factor receptor 3.726e-26 0.64
M3K7_HUMAN MAP3K7 Mitogen-activated protein kinase kinase kinase 7 1.454e-22 0.36
ADA1A_RABIT ADRA1A Alpha-1A adrenergic receptor 1.786e-21 0.30
CCR1_HUMAN CCR1 C-C chemokine receptor type 1 3.843e-21 0.34
GYRB_MYCSM gyrB DNA gyrase subunit B 1.467e-20 0.35
AUKBA_XENLA aurkb-a Aurora kinase B-A 4.748e-20 0.32
REV1_HUMAN REV1 DNA repair protein REV1 7.662e-18 0.37
ERBB3_HUMAN ERBB3 Receptor tyrosine-protein kinase erbB-3 1.11e-16 0.33
CDKL1_HUMAN CDKL1 Cyclin-dependent kinase-like 1 2.22e-16 0.36
EPHA2_HUMAN EPHA2 Ephrin type-A receptor 2 2.442e-15 0.36
CCNT1_HUMAN CCNT1 Cyclin-T1 6.772e-15 0.34
TNI3K_HUMAN TNNI3K Serine/threonine-protein kinase TNNI3K 1.354e-14 0.36
M3K6_HUMAN MAP3K6 Mitogen-activated protein kinase kinase kinase 6 1.454e-14 0.36
IGF1R_HUMAN IGF1R Insulin-like growth factor 1 receptor 4.263e-14 0.38
CD11B_HUMAN CDK11B Cyclin-dependent kinase 11B 9.603e-14 0.36
ACM5_RAT Chrm5 Muscarinic acetylcholine receptor M5 2.515e-13 0.33
ERBB2_HUMAN ERBB2 Receptor tyrosine-protein kinase erbB-2 8.133e-13 0.33
EPHB4_HUMAN EPHB4 Ephrin type-B receptor 4 1.741e-12 0.36
CDKL3_HUMAN CDKL3 Cyclin-dependent kinase-like 3 3.446e-12 0.36
TPOR_HUMAN MPL Thrombopoietin receptor 1.174e-11 0.33
HD_HUMAN HTT Huntingtin 1.565e-11 0.33
C3SLB7_ECOLX glmU Bifunctional protein GlmU 1.729e-11 0.29
CDKL2_HUMAN CDKL2 Cyclin-dependent kinase-like 2 2.422e-11 0.36
MAK_HUMAN MAK Serine/threonine-protein kinase MAK 2.451e-11 0.36
STAT6_HUMAN STAT6 Signal transducer and activator of transcription 6 3.914e-11 0.30
LTK_HUMAN LTK Leukocyte tyrosine kinase receptor 7.018e-11 0.38
TNIK_HUMAN TNIK TRAF2 and NCK-interacting protein kinase 7.186e-11 0.36
KAPCB_HUMAN PRKACB cAMP-dependent protein kinase catalytic subunit beta 1.255e-10 0.36
ST38L_HUMAN STK38L Serine/threonine-protein kinase 38-like 1.255e-10 0.36
CDK9_HUMAN CDK9 Cyclin-dependent kinase 9 2.279e-10 0.38
CSF1R_HUMAN CSF1R Macrophage colony-stimulating factor 1 receptor 3.521e-10 0.38
NEK9_HUMAN NEK9 Serine/threonine-protein kinase Nek9 5.012e-10 0.36
MK10_HUMAN MAPK10 Mitogen-activated protein kinase 10 1.491e-09 0.36
CDKL5_HUMAN CDKL5 Cyclin-dependent kinase-like 5 1.651e-09 0.36
KCC4_HUMAN CAMK4 Calcium/calmodulin-dependent protein kinase type IV 1.651e-09 0.36
MYO3A_HUMAN MYO3A Myosin-IIIa 1.651e-09 0.36
STK39_HUMAN STK39 STE20/SPS1-related proline-alanine-rich protein kinase 1.651e-09 0.36
MELK_HUMAN MELK Maternal embryonic leucine zipper kinase 1.853e-09 0.36
5HT4R_HUMAN HTR4 5-hydroxytryptamine receptor 4 2.792e-09 0.33
CD11A_HUMAN CDK11A Cyclin-dependent kinase 11A 4.671e-09 0.36
CDK13_HUMAN CDK13 Cyclin-dependent kinase 13 4.671e-09 0.36
MYO3B_HUMAN MYO3B Myosin-IIIb 4.671e-09 0.36
ZAP70_HUMAN ZAP70 Tyrosine-protein kinase ZAP-70 9.627e-09 0.33
NEK5_HUMAN NEK5 Serine/threonine-protein kinase Nek5 1.168e-08 0.36
CDK16_HUMAN CDK16 Cyclin-dependent kinase 16 1.339e-08 0.36
MP2K1_HUMAN MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 1.805e-08 0.38
MKNK1_HUMAN MKNK1 MAP kinase-interacting serine/threonine-protein kinase 1 1.92e-08 0.36
SRMS_HUMAN SRMS Tyrosine-protein kinase Srms 2.497e-08 0.36
M3K1_HUMAN MAP3K1 Mitogen-activated protein kinase kinase kinase 1 2.638e-08 0.36
JAK3_HUMAN JAK3 Tyrosine-protein kinase JAK3 2.695e-08 0.38
WEE1_HUMAN WEE1 Wee1-like protein kinase 4.258e-08 0.43
MP2K2_HUMAN MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 4.343e-08 0.38
DYR1B_HUMAN DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B 4.422e-08 0.38
CDK15_HUMAN CDK15 Cyclin-dependent kinase 15 5.477e-08 0.36
LATS1_HUMAN LATS1 Serine/threonine-protein kinase LATS1 5.477e-08 0.36
SGK3_HUMAN SGK3 Serine/threonine-protein kinase Sgk3 5.477e-08 0.36
DRD4_HUMAN DRD4 D(4) dopamine receptor 6.492e-08 0.35
ACM4_RAT Chrm4 Muscarinic acetylcholine receptor M4 7.342e-08 0.34
AVR2B_HUMAN ACVR2B Activin receptor type-2B 1.059e-07 0.36
CDK18_HUMAN CDK18 Cyclin-dependent kinase 18 1.059e-07 0.36
STK24_HUMAN STK24 Serine/threonine-protein kinase 24 1.059e-07 0.36
RET4_HUMAN RBP4 Retinol-binding protein 4 1.67e-07 0.30
KCC1D_HUMAN CAMK1D Calcium/calmodulin-dependent protein kinase type 1D 1.841e-07 0.38
NEK6_HUMAN NEK6 Serine/threonine-protein kinase Nek6 1.927e-07 0.36
RIPK4_HUMAN RIPK4 Receptor-interacting serine/threonine-protein kinase 4 1.927e-07 0.36
MK09_HUMAN MAPK9 Mitogen-activated protein kinase 9 2.694e-07 0.38
O97467_PLAFA ht1 Hexose transporter 1 2.75e-07 0.33
5HT3A_CAVPO HTR3A 5-hydroxytryptamine receptor 3A 3.236e-07 0.30
MP2K5_HUMAN MAP2K5 Dual specificity mitogen-activated protein kinase kinase 5 3.301e-07 0.36
CILK1_HUMAN CILK1 Serine/threonine-protein kinase ICK 3.33e-07 0.36
INSRR_HUMAN INSRR Insulin receptor-related protein 3.33e-07 0.36
DPOL_VACCW POL DNA polymerase 3.411e-07 0.36
AURKA_HUMAN AURKA Aurora kinase A 3.92e-07 0.38
STK10_HUMAN STK10 Serine/threonine-protein kinase 10 4.972e-07 0.36
5HT1B_HUMAN HTR1B 5-hydroxytryptamine receptor 1B 5.158e-07 0.36
ADA1D_RAT Adra1d Alpha-1D adrenergic receptor 5.268e-07 0.30
CDK14_HUMAN CDK14 Cyclin-dependent kinase 14 5.5e-07 0.36
DUSTY_HUMAN DSTYK Dual serine/threonine and tyrosine protein kinase 5.5e-07 0.36
LATS2_HUMAN LATS2 Serine/threonine-protein kinase LATS2 5.5e-07 0.36
TESK1_HUMAN TESK1 Dual specificity testis-specific protein kinase 1 5.5e-07 0.36
ALR_HUMAN GFER FAD-linked sulfhydryl oxidase ALR 7.297e-07 0.37
HCK_HUMAN HCK Tyrosine-protein kinase HCK 8.247e-07 0.36
GYRB_MYCS2 gyrB DNA gyrase subunit B 8.679e-07 0.29
CDK17_HUMAN CDK17 Cyclin-dependent kinase 17 8.733e-07 0.36
M3K13_HUMAN MAP3K13 Mitogen-activated protein kinase kinase kinase 13 8.733e-07 0.36
5HT1D_CAVPO HTR1D 5-hydroxytryptamine receptor 1D 9.396e-07 0.29
KKCC2_HUMAN CAMKK2 Calcium/calmodulin-dependent protein kinase kinase 2 9.923e-07 0.36
5HT2A_PIG HTR2A 5-hydroxytryptamine receptor 2A 1.026e-06 0.33
ANKK1_HUMAN ANKK1 Ankyrin repeat and protein kinase domain-containing protein 1 1.339e-06 0.36
STK35_HUMAN STK35 Serine/threonine-protein kinase 35 1.339e-06 0.36
DAPK3_HUMAN DAPK3 Death-associated protein kinase 3 1.503e-06 0.38
PAK1_HUMAN PAK1 Serine/threonine-protein kinase PAK 1 1.741e-06 0.32
O61059_LEIME LmGT2 Glucose transporter 1.817e-06 0.33
CDPK1_PLAF7 CPK1 Calcium-dependent protein kinase 1 1.993e-06 0.36
MUSK_HUMAN MUSK Muscle, skeletal receptor tyrosine-protein kinase 1.993e-06 0.36
STK25_HUMAN STK25 Serine/threonine-protein kinase 25 1.993e-06 0.36
M3K19_HUMAN MAP3K19 Mitogen-activated protein kinase kinase kinase 19 2.025e-06 0.36
MK07_HUMAN MAPK7 Mitogen-activated protein kinase 7 2.198e-06 0.29
KKCC1_HUMAN CAMKK1 Calcium/calmodulin-dependent protein kinase kinase 1 2.885e-06 0.36
RIOK2_HUMAN RIOK2 Serine/threonine-protein kinase RIO2 2.885e-06 0.36
STK36_HUMAN STK36 Serine/threonine-protein kinase 36 2.885e-06 0.36
ULK3_HUMAN ULK3 Serine/threonine-protein kinase ULK3 2.885e-06 0.36
DRD3_RAT Drd3 D(3) dopamine receptor 3.674e-06 0.33
CLK3_HUMAN CLK3 Dual specificity protein kinase CLK3 4.796e-06 0.36
MKNK2_HUMAN MKNK2 MAP kinase-interacting serine/threonine-protein kinase 2 4.935e-06 0.36
CAC1G_HUMAN CACNA1G Voltage-dependent T-type calcium channel subunit alpha-1G 5.138e-06 0.35
MYLK2_HUMAN MYLK2 Myosin light chain kinase 2, skeletal/cardiac muscle 5.635e-06 0.36
CDK7_HUMAN CDK7 Cyclin-dependent kinase 7 5.762e-06 0.38
CDK19_HUMAN CDK19 Cyclin-dependent kinase 19 6.705e-06 0.38
MDHC_HUMAN MDH1 Malate dehydrogenase, cytoplasmic 7.112e-06 0.29
PMYT1_HUMAN PKMYT1 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase 7.185e-06 0.30
MK15_HUMAN MAPK15 Mitogen-activated protein kinase 15 7.64e-06 0.36
ULK1_HUMAN ULK1 Serine/threonine-protein kinase ULK1 7.64e-06 0.36
MP2K6_HUMAN MAP2K6 Dual specificity mitogen-activated protein kinase kinase 6 9.436e-06 0.29

Capmatinib

MET_HUMAN MET Hepatocyte growth factor receptor 5.135e-61 1.00
MK01_HUMAN MAPK1 Mitogen-activated protein kinase 1 8.005e-29 0.36
PDPK1_HUMAN PDPK1 3-phosphoinositide-dependent protein kinase 1 1.124e-25 0.42
PDE1A_HUMAN PDE1A Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 3.026e-17 0.38
CDKL1_HUMAN CDKL1 Cyclin-dependent kinase-like 1 5.107e-15 0.33
SUCR1_HUMAN SUCNR1 Succinate receptor 1 8.86e-13 0.31
CYSP_TRYCR Cruzipain 2.196e-11 0.34
PDE3B_HUMAN PDE3B cGMP-inhibited 3',5'-cyclic phosphodiesterase B 1.208e-10 0.38
PDE1C_HUMAN PDE1C Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C 2.909e-10 0.38
PDE4C_HUMAN PDE4C cAMP-specific 3',5'-cyclic phosphodiesterase 4C 3.718e-10 0.38
PDE2A_HUMAN PDE2A cGMP-dependent 3',5'-cyclic phosphodiesterase 1.805e-09 0.39
CCR1_MOUSE Ccr1 C-C chemokine receptor type 1 3.078e-09 0.29
TGFR1_HUMAN TGFBR1 TGF-beta receptor type-1 4.416e-08 0.33
CRCM1_HUMAN ORAI1 Calcium release-activated calcium channel protein 1 1.053e-07 0.36
GSK3B_MOUSE Gsk3b Glycogen synthase kinase-3 beta 1.121e-07 0.28
IKKB_HUMAN IKBKB Inhibitor of nuclear factor kappa-B kinase subunit beta 1.574e-07 0.33
CP2C8_HUMAN CYP2C8 Cytochrome P450 2C8 6.257e-07 0.29
PDE5A_CANLF PDE5A cGMP-specific 3',5'-cyclic phosphodiesterase 1.057e-06 0.38
GRM1_MOUSE Grm1 Metabotropic glutamate receptor 1 1.894e-06 0.29
FAK2_MOUSE Ptk2b Protein-tyrosine kinase 2-beta 2.153e-06 0.30
PDE3A_HUMAN PDE3A cGMP-inhibited 3',5'-cyclic phosphodiesterase A 5.407e-06 0.38

Osilodrostat

C11B2_RAT Cyp11b2 Cytochrome P450 11B2, mitochondrial 2.441e-59 1.00
C11B1_RAT Cyp11b1 Cytochrome P450 11B1, mitochondrial 2.662e-48 1.00
C11B2_MOUSE Cyp11b2 Cytochrome P450 11B2, mitochondrial 4.293e-26 1.00
C11B2_HUMAN CYP11B2 Cytochrome P450 11B2, mitochondrial 1.46e-24 1.00
C11B1_HUMAN CYP11B1 Cytochrome P450 11B1, mitochondrial 4.596e-14 1.00
CP19A_HUMAN CYP19A1 Aromatase 3.052e-07 1.00
PGTB1_MOUSE Pggt1b Geranylgeranyl transferase type-1 subunit beta 3.317e-24 0.30
ACHA5_HUMAN CHRNA5 Neuronal acetylcholine receptor subunit alpha-5 3.032e-08 0.29
DCK_HUMAN DCK Deoxycytidine kinase 5.882e-08 0.31
OX2R_RAT Hcrtr2 Orexin receptor type 2 7.088e-08 0.28
GPR6_HUMAN GPR6 G-protein coupled receptor 6 1.447e-06 0.34

Selumetinib

MP2K1_HUMAN MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 3.55e-57 1.00
MP2K2_HUMAN MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 5.738e-07 1.00
EGFR_HUMAN EGFR Epidermal growth factor receptor 0.9782 1.00
MP2K1_MOUSE Map2k1 Dual specificity mitogen-activated protein kinase kinase 1 3.139e-42 0.35

Cabotegravir

Q76353_9HIV1 Integrase 2.28e-51 1.00
GLYCP_NIPAV G Glycoprotein G 1.37e-68 0.35
DPOL_HHV11 DNA polymerase catalytic subunit 6.494e-40 0.32
DPOL_VZVD DNA polymerase catalytic subunit 6.494e-40 0.32
DPOL_HCMVA UL54 DNA polymerase catalytic subunit 1.275e-33 0.32
P2RX7_HUMAN P2RX7 P2X purinoceptor 7 6.366e-33 0.36
Q7ZJM1_9HIV1 pol Integrase 2.485e-19 0.36
DPOLA_HUMAN POLA1 DNA polymerase alpha catalytic subunit 5.523e-08 0.34
VACHT_RAT Slc18a3 Vesicular acetylcholine transporter 6.925e-07 0.84
KCNK3_HUMAN KCNK3 Potassium channel subfamily K member 3 8.558e-06 0.39
CNR1_MOUSE Cnr1 Cannabinoid receptor 1 9.634e-06 0.30

Talazoparib

PAR16_HUMAN PARP16 Protein mono-ADP-ribosyltransferase PARP16 1.089e-50 1.00
PARP4_HUMAN PARP4 Protein mono-ADP-ribosyltransferase PARP4 3.937e-30 1.00
PARP1_HUMAN PARP1 Poly [ADP-ribose] polymerase 1 1.023e-23 1.00
PARP3_HUMAN PARP3 Protein mono-ADP-ribosyltransferase PARP3 1.897e-17 1.00
PARP2_HUMAN PARP2 Poly [ADP-ribose] polymerase 2 1.014e-13 1.00
PAR10_HUMAN PARP10 Protein mono-ADP-ribosyltransferase PARP10 3.375e-10 1.00
TNKS2_HUMAN TNKS2 Poly [ADP-ribose] polymerase tankyrase-2 3.107e-06 1.00
TNKS1_HUMAN TNKS Poly [ADP-ribose] polymerase tankyrase-1 0.0408 1.00

Gilteritinib

ROS1_HUMAN ROS1 Proto-oncogene tyrosine-protein kinase ROS 2.981e-50 1.00
ALK_HUMAN ALK ALK tyrosine kinase receptor 2.027e-49 1.00
RET_HUMAN RET Proto-oncogene tyrosine-protein kinase receptor Ret 8.859e-24 1.00
UFO_HUMAN AXL Tyrosine-protein kinase receptor UFO 1.432e-14 1.00
FLT3_HUMAN FLT3 Receptor-type tyrosine-protein kinase FLT3 1.136e-12 1.00
EHMT1_HUMAN EHMT1 Histone-lysine N-methyltransferase EHMT1 1.359e-151 0.44
EHMT2_HUMAN EHMT2 Histone-lysine N-methyltransferase EHMT2 1.16e-144 0.44
CCR4_MOUSE Ccr4 C-C chemokine receptor type 4 8.53e-94 0.40
5HT1D_RAT Htr1d 5-hydroxytryptamine receptor 1D 2.138e-44 0.33
INSR_RAT Insr Insulin receptor 4.902e-40 0.32
EPHA2_HUMAN EPHA2 Ephrin type-A receptor 2 1.005e-35 0.35
CCR4_HUMAN CCR4 C-C chemokine receptor type 4 1.081e-30 0.40
INSR_HUMAN INSR Insulin receptor 1.301e-29 0.39
EPHB4_HUMAN EPHB4 Ephrin type-B receptor 4 1.507e-27 0.35
CSF1R_HUMAN CSF1R Macrophage colony-stimulating factor 1 receptor 5.024e-27 0.38
EGFR_HUMAN EGFR Epidermal growth factor receptor 5.819e-27 0.57
IGF1R_HUMAN IGF1R Insulin-like growth factor 1 receptor 3.126e-26 0.39
5HT1D_CAVPO HTR1D 5-hydroxytryptamine receptor 1D 4.877e-26 0.30
TNIK_HUMAN TNIK TRAF2 and NCK-interacting protein kinase 4.036e-25 0.34
ADA2A_PIG ADRA2A Alpha-2A adrenergic receptor 1.239e-23 0.29
TTK_HUMAN TTK Dual specificity protein kinase TTK 2.221e-22 0.36
NEK3_HUMAN NEK3 Serine/threonine-protein kinase Nek3 2.576e-22 0.32
RIPK1_MOUSE Ripk1 Receptor-interacting serine/threonine-protein kinase 1 3.16e-21 0.31
ADA1A_RABIT ADRA1A Alpha-1A adrenergic receptor 1.101e-20 0.33
E2AK3_HUMAN EIF2AK3 Eukaryotic translation initiation factor 2-alpha kinase 3 1.797e-20 0.31
KSYK_HUMAN SYK Tyrosine-protein kinase SYK 4.658e-20 0.35
ST32C_HUMAN STK32C Serine/threonine-protein kinase 32C 6.128e-20 0.32
AUKBA_XENLA aurkb-a Aurora kinase B-A 2.262e-18 0.29
BKRB1_MACFA BDKRB1 B1 bradykinin receptor 2.819e-18 0.30
CD63_HUMAN CD63 CD63 antigen 6.255e-18 0.34
MP2K1_MOUSE Map2k1 Dual specificity mitogen-activated protein kinase kinase 1 7.502e-18 0.28
MERTK_HUMAN MERTK Tyrosine-protein kinase Mer 1.69e-17 0.32
STAT6_HUMAN STAT6 Signal transducer and activator of transcription 6 5.502e-17 0.33
5HT1B_RAT Htr1b 5-hydroxytryptamine receptor 1B 1.11e-16 0.33
KS6A6_HUMAN RPS6KA6 Ribosomal protein S6 kinase alpha-6 1.11e-16 0.32
PAK1_HUMAN PAK1 Serine/threonine-protein kinase PAK 1 4.441e-16 0.40
MYO3A_HUMAN MYO3A Myosin-IIIa 6.661e-16 0.32
LTK_HUMAN LTK Leukocyte tyrosine kinase receptor 1.332e-15 0.37
KCC4_HUMAN CAMK4 Calcium/calmodulin-dependent protein kinase type IV 1.998e-15 0.32
OXSR1_HUMAN OXSR1 Serine/threonine-protein kinase OSR1 1.998e-15 0.32
COQ8A_HUMAN COQ8A Atypical kinase COQ8A, mitochondrial 2.554e-15 0.32
MYO3B_HUMAN MYO3B Myosin-IIIb 4.108e-15 0.32
5HT1B_GORGO HTR1B 5-hydroxytryptamine receptor 1B 7.438e-15 0.28
SNRK_HUMAN SNRK SNF-related serine/threonine-protein kinase 1.71e-14 0.32
NEK7_HUMAN NEK7 Serine/threonine-protein kinase Nek7 1.976e-14 0.32
HUNK_HUMAN HUNK Hormonally up-regulated neu tumor-associated kinase 8.027e-14 0.32
NIM1_HUMAN NIM1K Serine/threonine-protein kinase NIM1 8.027e-14 0.32
PLK1_HUMAN PLK1 Serine/threonine-protein kinase PLK1 8.138e-14 0.35
FER_HUMAN FER Tyrosine-protein kinase Fer 2.369e-13 0.33
CASB_RAT Csn2 Beta-casein 2.482e-13 0.29
FAK1_HUMAN PTK2 Focal adhesion kinase 1 2.682e-13 0.37
FAK2_HUMAN PTK2B Protein-tyrosine kinase 2-beta 3.244e-13 0.33
MK07_HUMAN MAPK7 Mitogen-activated protein kinase 7 3.583e-13 0.33
GRK7_HUMAN GRK7 Rhodopsin kinase GRK7 4.333e-13 0.32
ALK_MOUSE Alk ALK tyrosine kinase receptor 6.003e-13 0.32
M3K6_HUMAN MAP3K6 Mitogen-activated protein kinase kinase kinase 6 6.003e-13 0.32
DAPK2_HUMAN DAPK2 Death-associated protein kinase 2 1.487e-12 0.32
MK08_HUMAN MAPK8 Mitogen-activated protein kinase 8 2.118e-12 0.37
STK16_HUMAN STK16 Serine/threonine-protein kinase 16 2.627e-12 0.32
5HT1D_MOUSE Htr1d 5-hydroxytryptamine receptor 1D 2.757e-12 0.30
DCLK1_HUMAN DCLK1 Serine/threonine-protein kinase DCLK1 2.824e-12 0.33
DAPK1_HUMAN DAPK1 Death-associated protein kinase 1 4.509e-12 0.32
ERBB2_HUMAN ERBB2 Receptor tyrosine-protein kinase erbB-2 4.516e-12 0.33
HIPK3_HUMAN HIPK3 Homeodomain-interacting protein kinase 3 7.54e-12 0.32
LRRK2_HUMAN LRRK2 Leucine-rich repeat serine/threonine-protein kinase 2 1.007e-11 0.37
STK33_HUMAN STK33 Serine/threonine-protein kinase 33 1.302e-11 0.34
INSRR_HUMAN INSRR Insulin receptor-related protein 1.375e-11 0.32
KS6A1_HUMAN RPS6KA1 Ribosomal protein S6 kinase alpha-1 1.504e-11 0.32
DUSTY_HUMAN DSTYK Dual serine/threonine and tyrosine protein kinase 3.168e-11 0.32
HIPK1_HUMAN HIPK1 Homeodomain-interacting protein kinase 1 1.05e-10 0.32
ADA1D_RAT Adra1d Alpha-1D adrenergic receptor 1.614e-10 0.33
TYRO3_HUMAN TYRO3 Tyrosine-protein kinase receptor TYRO3 1.835e-10 0.35
KKCC1_HUMAN CAMKK1 Calcium/calmodulin-dependent protein kinase kinase 1 2.526e-10 0.32
RIOK3_HUMAN RIOK3 Serine/threonine-protein kinase RIO3 2.526e-10 0.32
TSSK1_HUMAN TSSK1B Testis-specific serine/threonine-protein kinase 1 2.61e-10 0.33
M3K15_HUMAN MAP3K15 Mitogen-activated protein kinase kinase kinase 15 4.255e-10 0.32
STK38_HUMAN STK38 Serine/threonine-protein kinase 38 4.255e-10 0.32
DMPK_HUMAN DMPK Myotonin-protein kinase 4.564e-10 0.32
FES_HUMAN FES Tyrosine-protein kinase Fes/Fps 5.169e-10 0.32
ADA1B_HUMAN ADRA1B Alpha-1B adrenergic receptor 5.569e-10 0.32
STK36_HUMAN STK36 Serine/threonine-protein kinase 36 5.832e-10 0.32
LCK_HUMAN LCK Tyrosine-protein kinase Lck 5.861e-10 0.37
5HT1B_HUMAN HTR1B 5-hydroxytryptamine receptor 1B 6.305e-10 0.35
PLK2_HUMAN PLK2 Serine/threonine-protein kinase PLK2 8.102e-10 0.32
RON_HUMAN MST1R Macrophage-stimulating protein receptor 8.551e-10 0.37
GRK1_HUMAN GRK1 Rhodopsin kinase GRK1 1.512e-09 0.32
ADA1A_RAT Adra1a Alpha-1A adrenergic receptor 1.537e-09 0.32
AVR2A_HUMAN ACVR2A Activin receptor type-2A 1.802e-09 0.32
KAPCB_HUMAN PRKACB cAMP-dependent protein kinase catalytic subunit beta 1.802e-09 0.32
ST32B_HUMAN STK32B Serine/threonine-protein kinase 32B 1.802e-09 0.32
ST38L_HUMAN STK38L Serine/threonine-protein kinase 38-like 1.802e-09 0.32
KS6A4_HUMAN RPS6KA4 Ribosomal protein S6 kinase alpha-4 2.167e-09 0.32
VGFR2_HUMAN KDR Vascular endothelial growth factor receptor 2 4.015e-09 0.35
MP2K3_HUMAN MAP2K3 Dual specificity mitogen-activated protein kinase kinase 3 4.026e-09 0.32
PHKG1_HUMAN PHKG1 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 4.026e-09 0.32
TNK1_HUMAN TNK1 Non-receptor tyrosine-protein kinase TNK1 4.026e-09 0.32
ADA1A_HUMAN ADRA1A Alpha-1A adrenergic receptor 4.246e-09 0.32
5HT1D_HUMAN HTR1D 5-hydroxytryptamine receptor 1D 4.695e-09 0.35
KCC2D_HUMAN CAMK2D Calcium/calmodulin-dependent protein kinase type II subunit delta 5.608e-09 0.37
NEK9_HUMAN NEK9 Serine/threonine-protein kinase Nek9 6.127e-09 0.32
MP2K4_HUMAN MAP2K4 Dual specificity mitogen-activated protein kinase kinase 4 6.301e-09 0.32
MTOR_HUMAN MTOR Serine/threonine-protein kinase mTOR 6.576e-09 0.35
KKCC2_HUMAN CAMKK2 Calcium/calmodulin-dependent protein kinase kinase 2 7.221e-09 0.32
M3K19_HUMAN MAP3K19 Mitogen-activated protein kinase kinase kinase 19 1.705e-08 0.32
CSKP_HUMAN CASK Peripheral plasma membrane protein CASK 1.758e-08 0.32
MAST1_HUMAN MAST1 Microtubule-associated serine/threonine-protein kinase 1 1.758e-08 0.32
STK39_HUMAN STK39 STE20/SPS1-related proline-alanine-rich protein kinase 1.758e-08 0.32
GAK_HUMAN GAK Cyclin-G-associated kinase 1.77e-08 0.32
ADA1D_HUMAN ADRA1D Alpha-1D adrenergic receptor 2.353e-08 0.32
KPCD1_HUMAN PRKD1 Serine/threonine-protein kinase D1 2.629e-08 0.32
ADA2A_RAT Adra2a Alpha-2A adrenergic receptor 3.255e-08 0.30
DCLK2_HUMAN DCLK2 Serine/threonine-protein kinase DCLK2 4.408e-08 0.32
KC1AL_HUMAN CSNK1A1L Casein kinase I isoform alpha-like 4.408e-08 0.32
MRCKB_HUMAN CDC42BPB Serine/threonine-protein kinase MRCK beta 4.408e-08 0.32
MRCKG_HUMAN CDC42BPG Serine/threonine-protein kinase MRCK gamma 4.408e-08 0.32
ST32A_HUMAN STK32A Serine/threonine-protein kinase 32A 4.408e-08 0.32
TSSK2_HUMAN TSSK2 Testis-specific serine/threonine-protein kinase 2 4.512e-08 0.33
PLK3_HUMAN PLK3 Serine/threonine-protein kinase PLK3 4.815e-08 0.32
MARK4_HUMAN MARK4 MAP/microtubule affinity-regulating kinase 4 6.141e-08 0.32
DAPK3_HUMAN DAPK3 Death-associated protein kinase 3 6.183e-08 0.34
KMT5A_HUMAN KMT5A N-lysine methyltransferase KMT5A 6.883e-08 0.29
COQ8B_HUMAN COQ8B Atypical kinase COQ8B, mitochondrial 9.91e-08 0.32
SBK3_HUMAN SBK3 Uncharacterized serine/threonine-protein kinase SBK3 9.91e-08 0.32
SIK3_HUMAN SIK3 Serine/threonine-protein kinase SIK3 9.91e-08 0.32
ERBB4_HUMAN ERBB4 Receptor tyrosine-protein kinase erbB-4 1.255e-07 0.33
MP2K2_HUMAN MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 1.443e-07 0.33
M3K1_HUMAN MAP3K1 Mitogen-activated protein kinase kinase kinase 1 2.037e-07 0.32
PRP4B_HUMAN PRPF4B Serine/threonine-protein kinase PRP4 homolog 2.037e-07 0.32
MK10_HUMAN MAPK10 Mitogen-activated protein kinase 10 2.187e-07 0.42
NUAK1_HUMAN NUAK1 NUAK family SNF1-like kinase 1 2.672e-07 0.32
ADA1B_RAT Adra1b Alpha-1B adrenergic receptor 2.75e-07 0.32
TIE2_HUMAN TEK Angiopoietin-1 receptor 2.822e-07 0.32
SYK_HUMAN KARS1 Lysine--tRNA ligase 3.074e-07 0.32
AAK1_HUMAN AAK1 AP2-associated protein kinase 1 3.234e-07 0.32
CDK15_HUMAN CDK15 Cyclin-dependent kinase 15 3.887e-07 0.32
LATS1_HUMAN LATS1 Serine/threonine-protein kinase LATS1 3.887e-07 0.32
ACK1_HUMAN TNK2 Activated CDC42 kinase 1 5.652e-07 0.37
MYLK_HUMAN MYLK Myosin light chain kinase, smooth muscle 5.871e-07 0.32
AVR2B_HUMAN ACVR2B Activin receptor type-2B 6.965e-07 0.32
KCC1G_HUMAN CAMK1G Calcium/calmodulin-dependent protein kinase type 1G 6.965e-07 0.32
SBK1_HUMAN SBK1 Serine/threonine-protein kinase SBK1 6.965e-07 0.32
STK24_HUMAN STK24 Serine/threonine-protein kinase 24 6.965e-07 0.32
KCC1D_HUMAN CAMK1D Calcium/calmodulin-dependent protein kinase type 1D 7.277e-07 0.32
KCC2A_HUMAN CAMK2A Calcium/calmodulin-dependent protein kinase type II subunit alpha 7.505e-07 0.33
SIK2_HUMAN SIK2 Serine/threonine-protein kinase SIK2 8.257e-07 0.32
ABL1_MOUSE Abl1 Tyrosine-protein kinase ABL1 9.396e-07 0.29
M3K10_HUMAN MAP3K10 Mitogen-activated protein kinase kinase kinase 10 1.017e-06 0.32
BRDT_HUMAN BRDT Bromodomain testis-specific protein 1.037e-06 0.30
MATK_HUMAN MATK Megakaryocyte-associated tyrosine-protein kinase 1.159e-06 0.33
BRSK2_HUMAN BRSK2 Serine/threonine-protein kinase BRSK2 1.183e-06 0.32
NEK6_HUMAN NEK6 Serine/threonine-protein kinase Nek6 1.183e-06 0.32
PAK6_HUMAN PAK6 Serine/threonine-protein kinase PAK 6 1.183e-06 0.32
RIPK4_HUMAN RIPK4 Receptor-interacting serine/threonine-protein kinase 4 1.183e-06 0.32
STK10_HUMAN STK10 Serine/threonine-protein kinase 10 1.393e-06 0.32
PHKG2_HUMAN PHKG2 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 1.43e-06 0.32
BRAF_HUMAN BRAF Serine/threonine-protein kinase B-raf 1.909e-06 0.35
CILK1_HUMAN CILK1 Serine/threonine-protein kinase ICK 1.919e-06 0.32
M3K4_HUMAN MAP3K4 Mitogen-activated protein kinase kinase kinase 4 1.919e-06 0.32
BKRB1_RAT Bdkrb1 B1 bradykinin receptor 2.305e-06 0.29
TBK1_HUMAN TBK1 Serine/threonine-protein kinase TBK1 2.332e-06 0.34
Q8VBU5_MOUSE Pde4b Phosphodiesterase 2.748e-06 0.32
MK09_HUMAN MAPK9 Mitogen-activated protein kinase 9 2.869e-06 0.42
PK3CA_HUMAN PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 2.93e-06 0.35
LATS2_HUMAN LATS2 Serine/threonine-protein kinase LATS2 2.992e-06 0.32
MP2K6_HUMAN MAP2K6 Dual specificity mitogen-activated protein kinase kinase 6 2.992e-06 0.32
ADA1A_BOVIN ADRA1A Alpha-1A adrenergic receptor 3.248e-06 0.32
NEMO_HUMAN IKBKG NF-kappa-B essential modulator 4.26e-06 0.30
NTRK2_HUMAN NTRK2 BDNF/NT-3 growth factors receptor 4.354e-06 0.37
BMR1A_HUMAN BMPR1A Bone morphogenetic protein receptor type-1A 4.504e-06 0.32
CDK17_HUMAN CDK17 Cyclin-dependent kinase 17 4.504e-06 0.32
M3K13_HUMAN MAP3K13 Mitogen-activated protein kinase kinase kinase 13 4.504e-06 0.32
TAOK1_HUMAN TAOK1 Serine/threonine-protein kinase TAO1 4.908e-06 0.33
HIPK4_HUMAN HIPK4 Homeodomain-interacting protein kinase 4 5.647e-06 0.33
ANKK1_HUMAN ANKK1 Ankyrin repeat and protein kinase domain-containing protein 1 6.578e-06 0.32
MARK1_HUMAN MARK1 Serine/threonine-protein kinase MARK1 6.578e-06 0.32
PAK5_HUMAN PAK5 Serine/threonine-protein kinase PAK 5 6.578e-06 0.32
PI51A_HUMAN PIP5K1A Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha 6.578e-06 0.32
STK35_HUMAN STK35 Serine/threonine-protein kinase 35 6.578e-06 0.32
CDK7_HUMAN CDK7 Cyclin-dependent kinase 7 7.011e-06 0.37
HIPK2_HUMAN HIPK2 Homeodomain-interacting protein kinase 2 7.467e-06 0.33
MK01_HUMAN MAPK1 Mitogen-activated protein kinase 1 7.652e-06 0.32
FRK_HUMAN FRK Tyrosine-protein kinase FRK 7.704e-06 0.33
TAOK3_HUMAN TAOK3 Serine/threonine-protein kinase TAO3 8.272e-06 0.32
JAK3_HUMAN JAK3 Tyrosine-protein kinase JAK3 8.309e-06 0.35
KPCD2_HUMAN PRKD2 Serine/threonine-protein kinase D2 8.321e-06 0.33
NEK4_HUMAN NEK4 Serine/threonine-protein kinase Nek4 9.169e-06 0.33
CDPK1_PLAF7 CPK1 Calcium-dependent protein kinase 1 9.349e-06 0.32
MUSK_HUMAN MUSK Muscle, skeletal receptor tyrosine-protein kinase 9.349e-06 0.32
STK25_HUMAN STK25 Serine/threonine-protein kinase 25 9.349e-06 0.32

Ebastine

HRH1_HUMAN HRH1 Histamine H1 receptor 5.217e-50 1.00
HRH2_HUMAN HRH2 Histamine H2 receptor 5.879e-37 1.00
ACM3_HUMAN CHRM3 Muscarinic acetylcholine receptor M3 7.445e-32 1.00
DRD2_HUMAN DRD2 D(2) dopamine receptor 3.7e-30 1.00
DRD4_HUMAN DRD4 D(4) dopamine receptor 2.802e-28 1.00
DRD3_HUMAN DRD3 D(3) dopamine receptor 7.964e-28 1.00
5HT2A_HUMAN HTR2A 5-hydroxytryptamine receptor 2A 4.83e-23 1.00
ACM4_HUMAN CHRM4 Muscarinic acetylcholine receptor M4 5.473e-23 1.00
ACM5_HUMAN CHRM5 Muscarinic acetylcholine receptor M5 1.263e-22 1.00
SC6A3_HUMAN SLC6A3 Sodium-dependent dopamine transporter 1.182e-21 1.00
HRH1_CAVPO HRH1 Histamine H1 receptor 2.271e-21 1.00
5HT1A_HUMAN HTR1A 5-hydroxytryptamine receptor 1A 2.309e-21 1.00
ACM1_HUMAN CHRM1 Muscarinic acetylcholine receptor M1 1.342e-20 1.00
ADA1B_RAT Adra1b Alpha-1B adrenergic receptor 3.323e-18 1.00
ACM2_HUMAN CHRM2 Muscarinic acetylcholine receptor M2 4.293e-18 1.00
5HT2C_HUMAN HTR2C 5-hydroxytryptamine receptor 2C 2.22e-16 1.00
SC6A4_HUMAN SLC6A4 Sodium-dependent serotonin transporter 6.661e-15 1.00
NK2R_HUMAN TACR2 Substance-K receptor 2.021e-14 1.00
ACES_HUMAN ACHE Acetylcholinesterase 3.797e-14 1.00
SC6A2_HUMAN SLC6A2 Sodium-dependent noradrenaline transporter 1.092e-12 1.00
ADA1D_HUMAN ADRA1D Alpha-1D adrenergic receptor 2.204e-10 1.00
ADA2C_HUMAN ADRA2C Alpha-2C adrenergic receptor 2.998e-09 1.00
ADA2B_HUMAN ADRA2B Alpha-2B adrenergic receptor 3.376e-09 1.00
5HT2B_HUMAN HTR2B 5-hydroxytryptamine receptor 2B 5.79e-09 1.00
MDR1_HUMAN ABCB1 ATP-dependent translocase ABCB1 1.176e-08 1.00
KCNH2_HUMAN KCNH2 Potassium voltage-gated channel subfamily H member 2 8.721e-08 1.00
ADA2A_HUMAN ADRA2A Alpha-2A adrenergic receptor 1.753e-07 1.00
ADA1A_RAT Adra1a Alpha-1A adrenergic receptor 3.158e-07 1.00
DRD1_HUMAN DRD1 D(1A) dopamine receptor 7.479e-07 1.00
5HT1B_RAT Htr1b 5-hydroxytryptamine receptor 1B 1.053e-05 1.00
FYN_HUMAN FYN Tyrosine-protein kinase Fyn 0.0009137 1.00
5HT6R_HUMAN HTR6 5-hydroxytryptamine receptor 6 0.001365 1.00
ADRB3_HUMAN ADRB3 Beta-3 adrenergic receptor 0.03275 1.00
ERBB2_HUMAN ERBB2 Receptor tyrosine-protein kinase erbB-2 0.7112 1.00
AA3R_HUMAN ADORA3 Adenosine receptor A3 0.8592 1.00
EGFR_HUMAN EGFR Epidermal growth factor receptor 0.9292 1.00
CP2J2_HUMAN CYP2J2 Cytochrome P450 2J2 4.076e-127 0.64
SC6A3_RAT Slc6a3 Sodium-dependent dopamine transporter 7.243e-67 0.50
SC6A1_RAT Slc6a1 Sodium- and chloride-dependent GABA transporter 1 7.642e-56 0.39
SGMR1_MOUSE Sigmar1 Sigma non-opioid intracellular receptor 1 1.401e-53 0.45
DRD2_MOUSE Drd2 D(2) dopamine receptor 2.794e-50 0.45
AP2S1_RAT Ap2s1 AP-2 complex subunit sigma 2.241e-49 0.34
Q4DCQ3_TRYCC Superoxide dismutase 5.846e-48 0.31
ACM1_RAT Chrm1 Muscarinic acetylcholine receptor M1 2.859e-45 0.50
DCNL1_HUMAN DCUN1D1 DCN1-like protein 1 6.659e-43 0.32
HRH3_RAT Hrh3 Histamine H3 receptor 4.927e-42 0.41
5HT7R_RAT Htr7 5-hydroxytryptamine receptor 7 1.749e-40 0.43
SCN2A_RAT Scn2a Sodium channel protein type 2 subunit alpha 3.625e-40 0.44
CCR5_HUMAN CCR5 C-C chemokine receptor type 5 1.272e-39 0.44
CASR_MOUSE Casr Extracellular calcium-sensing receptor 1.551e-39 0.31
AMYP_RAT Amy2 Pancreatic alpha-amylase 3.136e-39 0.31
SC6A4_RAT Slc6a4 Sodium-dependent serotonin transporter 7.565e-39 0.48
DRD4_RAT Drd4 D(4) dopamine receptor 1.357e-38 0.42
DRD1_PIG DRD1 D(1A) dopamine receptor 1.792e-38 0.35
SGMR2_RAT Tmem97 Sigma intracellular receptor 2 1.02e-37 0.51
MCHR1_RAT Mchr1 Melanin-concentrating hormone receptor 1 3.302e-37 0.44
ANM6_HUMAN PRMT6 Protein arginine N-methyltransferase 6 4.922e-36 0.39
5HT2C_RAT Htr2c 5-hydroxytryptamine receptor 2C 9.514e-33 0.49
LMCPB_LEIME LMCPB Cysteine proteinase B 1.187e-32 0.33
5HT2A_RAT Htr2a 5-hydroxytryptamine receptor 2A 7.99e-32 0.46
Q8WSF8_APLCA Soluble acetylcholine receptor 9.481e-31 0.34
CCR3_RAT Ccr3 C-C chemokine receptor type 3 1.09e-30 0.35
5HT7R_MOUSE Htr7 5-hydroxytryptamine receptor 7 5.395e-30 0.37
CARM1_HUMAN CARM1 Histone-arginine methyltransferase CARM1 5.647e-30 0.39
NMD3A_RAT Grin3a Glutamate receptor ionotropic, NMDA 3A 7.486e-30 0.32
VMAT2_RAT Slc18a2 Synaptic vesicular amine transporter 3.681e-29 0.36
DRD2_RAT Drd2 D(2) dopamine receptor 7.172e-29 0.49
ACM2_RAT Chrm2 Muscarinic acetylcholine receptor M2 1.812e-28 0.50
ZN664_CAVPO ZNF664 Zinc finger protein 664 2.164e-27 0.34
5HT7R_HUMAN HTR7 5-hydroxytryptamine receptor 7 2.112e-26 0.42
SGMR1_HUMAN SIGMAR1 Sigma non-opioid intracellular receptor 1 7.639e-26 0.42
5HT1A_RAT Htr1a 5-hydroxytryptamine receptor 1A 1.009e-25 0.49
Q8WMX0_BOVIN Muscarinic receptor M1 1.122e-25 0.32
G7PWB2_MACFA Melanocortin receptor 5 3.865e-25 0.31
CCR3_MOUSE Ccr3 Probable C-C chemokine receptor type 3 2.267e-23 0.31
SGMR1_CAVPO SIGMAR1 Sigma non-opioid intracellular receptor 1 2.525e-23 0.51
FKB1A_RAT Fkbp1a Peptidyl-prolyl cis-trans isomerase FKBP1A 6.587e-23 0.29
5HT2A_PIG HTR2A 5-hydroxytryptamine receptor 2A 2.346e-22 0.35
MAP11_HUMAN METAP1 Methionine aminopeptidase 1 3.454e-22 0.31
ACHP_LYMST Acetylcholine-binding protein 2.515e-21 0.34
SC6A5_HUMAN SLC6A5 Sodium- and chloride-dependent glycine transporter 2 4.2e-21 0.34
SC6A4_MOUSE Slc6a4 Sodium-dependent serotonin transporter 1.245e-20 0.31
US28_HCMVA US28 G-protein coupled receptor homolog US28 1.473e-20 0.29
Q53I59_TRYCR PDEC Phosphodiesterase 1.835e-20 0.34
SC6A3_MACFA SLC6A3 Sodium-dependent dopamine transporter 2.021e-20 0.31
ACES_RAT Ache Acetylcholinesterase 5.487e-20 0.39
KCNK2_HUMAN KCNK2 Potassium channel subfamily K member 2 1.952e-19 0.34
ACES_MOUSE Ache Acetylcholinesterase 2.384e-19 0.42
PCP_HUMAN PRCP Lysosomal Pro-X carboxypeptidase 3.785e-19 0.37
Q9WTR4_RAT Slc6a2 Transporter 6.075e-19 0.37
5HT4R_HUMAN HTR4 5-hydroxytryptamine receptor 4 8.254e-19 0.35
5HT5A_MOUSE Htr5a 5-hydroxytryptamine receptor 5A 1.131e-18 0.40
MEN1_HUMAN MEN1 Menin 1.728e-18 0.37
CCR3_HUMAN CCR3 C-C chemokine receptor type 3 1.981e-18 0.36
MC5R_HUMAN MC5R Melanocortin receptor 5 3.287e-18 0.37
H10_HUMAN H1-0 Histone H1.0 1.072e-17 0.34
VMAT2_HUMAN SLC18A2 Synaptic vesicular amine transporter 3.169e-17 0.34
5HT7R_CAVPO HTR7 5-hydroxytryptamine receptor 7 3.896e-17 0.30
CAC1G_HUMAN CACNA1G Voltage-dependent T-type calcium channel subunit alpha-1G 1.11e-16 0.35
CASB_RAT Csn2 Beta-casein 1.11e-16 0.37
ERG2_YEAST ERG2 C-8 sterol isomerase 1.11e-16 0.37
S5A2_RAT Srd5a2 3-oxo-5-alpha-steroid 4-dehydrogenase 2 1.11e-16 0.29
S6A11_HUMAN SLC6A11 Sodium- and chloride-dependent GABA transporter 3 3.331e-16 0.31
CA2D1_RAT Cacna2d1 Voltage-dependent calcium channel subunit alpha-2/delta-1 6.661e-16 0.30
SGMR2_HUMAN TMEM97 Sigma intracellular receptor 2 6.661e-16 0.34
5HT3B_MOUSE Htr3b 5-hydroxytryptamine receptor 3B 1.443e-15 0.39
CAC1C_RAT Cacna1c Voltage-dependent L-type calcium channel subunit alpha-1C 1.443e-15 0.44
5HT2B_RAT Htr2b 5-hydroxytryptamine receptor 2B 3.22e-15 0.38
HRH3_CAVPO HRH3 Histamine H3 receptor 4.108e-15 0.34
NMDE2_HUMAN GRIN2B Glutamate receptor ionotropic, NMDA 2B 6.439e-15 0.46
NPCL1_HUMAN NPC1L1 NPC1-like intracellular cholesterol transporter 1 7.327e-15 0.30
SC5A7_HUMAN SLC5A7 High affinity choline transporter 1 8.216e-15 0.36
ACM1_DROME mAChR-A Muscarinic acetylcholine receptor DM1 1.277e-14 0.31
ACM3_RAT Chrm3 Muscarinic acetylcholine receptor M3 1.998e-14 0.45
DRD1_RAT Drd1 D(1A) dopamine receptor 3.275e-14 0.49
EBP_HUMAN EBP 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase 3.286e-14 0.37
CACB1_RAT Cacnb1 Voltage-dependent L-type calcium channel subunit beta-1 3.619e-14 0.30
ACM4_RAT Chrm4 Muscarinic acetylcholine receptor M4 4.263e-14 0.45
PCP_MOUSE Prcp Lysosomal Pro-X carboxypeptidase 4.341e-14 0.33
5HT4R_CAVPO HTR4 5-hydroxytryptamine receptor 4 4.396e-14 0.34
Q7M0F8_CAVPO Protein-glutamine gamma-glutamyltransferase, liver 7.15e-14 0.33
VMAT2_MOUSE Slc18a2 Synaptic vesicular amine transporter 9.315e-14 0.34
ACM5_RAT Chrm5 Muscarinic acetylcholine receptor M5 2.985e-13 0.32
S5A1_RAT Srd5a1 3-oxo-5-alpha-steroid 4-dehydrogenase 1 4.696e-13 0.29
Q8VH26_CAVPO GPM3 Muscarinic acetylcholine receptor 6.132e-13 0.32
SGMR1_RAT Sigmar1 Sigma non-opioid intracellular receptor 1 6.216e-13 0.39
LKHA4_HUMAN LTA4H Leukotriene A-4 hydrolase 8.676e-13 0.32
DRD5_RAT Drd5 D(1B) dopamine receptor 1.448e-12 0.37
PA24A_BOVIN PLA2G4A Cytosolic phospholipase A2 1.827e-12 0.30
PI2R_HUMAN PTGIR Prostacyclin receptor 5.871e-12 0.34
Q6Q253_PIG 5-HT4R 5-hydroxytryptamine receptor 4 protein 1.067e-11 0.32
PTGDS_MOUSE Ptgds Prostaglandin-H2 D-isomerase 1.503e-11 0.31
CP2D6_HUMAN CYP2D6 Cytochrome P450 2D6 1.632e-11 0.49
CAC1I_HUMAN CACNA1I Voltage-dependent T-type calcium channel subunit alpha-1I 1.838e-11 0.37
PLD1_RAT Pld1 Phospholipase D1 2.527e-11 0.30
Q63380_RAT NET Transporter 3.303e-11 0.34
S1PR5_HUMAN S1PR5 Sphingosine 1-phosphate receptor 5 6.277e-11 0.40
MRGX1_RAT Mrgprx1 Mas-related G-protein coupled receptor member X1 1.123e-10 0.29
ACES_ELEEL ache Acetylcholinesterase 1.734e-10 0.75
CAC1B_RAT Cacna1b Voltage-dependent N-type calcium channel subunit alpha-1B 2.587e-10 0.36
SC6A1_HUMAN SLC6A1 Sodium- and chloride-dependent GABA transporter 1 5.407e-10 0.33
PLD2_HUMAN PLD2 Phospholipase D2 7.865e-10 0.31
CASR_RAT Casr Extracellular calcium-sensing receptor 9.497e-10 0.31
HNF4A_RAT Hnf4a Hepatocyte nuclear factor 4-alpha 1.049e-09 0.28
PA2GA_HUMAN PLA2G2A Phospholipase A2, membrane associated 1.278e-09 0.30
DRD3_CHLAE DRD3 D(3) dopamine receptor 1.773e-09 0.34
MCHR1_HUMAN MCHR1 Melanin-concentrating hormone receptor 1 2.072e-09 0.42
HRH3_HUMAN HRH3 Histamine H3 receptor 2.932e-09 0.37
ADA1B_HUMAN ADRA1B Alpha-1B adrenergic receptor 3.944e-09 0.51
MTAP2_HUMAN MAP2 Microtubule-associated protein 2 5.171e-09 0.30
ANM8_HUMAN PRMT8 Protein arginine N-methyltransferase 8 9.578e-09 0.32
ACHB2_RAT Chrnb2 Neuronal acetylcholine receptor subunit beta-2 9.644e-09 0.36
VACHT_HUMAN SLC18A3 Vesicular acetylcholine transporter 1.576e-08 0.39
ACHA4_RAT Chrna4 Neuronal acetylcholine receptor subunit alpha-4 1.614e-08 0.36
PLD1_HUMAN PLD1 Phospholipase D1 2.395e-08 0.31
S6A13_MOUSE Slc6a13 Sodium- and chloride-dependent GABA transporter 2 2.668e-08 0.31
KITM_HUMAN TK2 Thymidine kinase 2, mitochondrial 3.72e-08 0.29
ADA1A_HUMAN ADRA1A Alpha-1A adrenergic receptor 4.063e-08 0.51
A0A072ZLE6_PSEAI mvfR LysR family transcriptional regulator 4.675e-08 0.28
OPRM_RAT Oprm1 Mu-type opioid receptor 5.043e-08 0.38
SCN1A_HUMAN SCN1A Sodium channel protein type 1 subunit alpha 5.753e-08 0.31
HNF4A_HUMAN HNF4A Hepatocyte nuclear factor 4-alpha 6.293e-08 0.28
THA_HUMAN THRA Thyroid hormone receptor alpha 7.615e-08 0.38
CHLE_HUMAN BCHE Cholinesterase 1.027e-07 0.38
Q8QGU2_CHICK FKBP12.6 Peptidylprolyl isomerase 1.276e-07 0.30
S6A11_MOUSE Slc6a11 Sodium- and chloride-dependent GABA transporter 3 1.445e-07 0.31
PA24A_HUMAN PLA2G4A Cytosolic phospholipase A2 1.992e-07 0.31
SFRP1_HUMAN SFRP1 Secreted frizzled-related protein 1 2.218e-07 0.31
SC6A3_MOUSE Slc6a3 Sodium-dependent dopamine transporter 5.079e-07 0.31
Q9JKC1_RAT Bche Carboxylic ester hydrolase 5.312e-07 0.35
ACM2_MOUSE Chrm2 Muscarinic acetylcholine receptor M2 5.385e-07 0.32
SCN9A_MOUSE Scn9a Sodium channel protein type 9 subunit alpha 6.656e-07 0.31
DRD3_RAT Drd3 D(3) dopamine receptor 7.269e-07 0.37
OPRD_RAT Oprd1 Delta-type opioid receptor 8.496e-07 0.38
DHB3_HUMAN HSD17B3 Testosterone 17-beta-dehydrogenase 3 8.765e-07 0.30
DNK_DROME dnk Deoxynucleoside kinase 9.396e-07 0.29
OPRM_MOUSE Oprm1 Mu-type opioid receptor 9.947e-07 0.38
PHF8_HUMAN PHF8 Histone lysine demethylase PHF8 1.122e-06 0.28
FAAH1_HUMAN FAAH Fatty-acid amide hydrolase 1 1.129e-06 0.33
HRH1_RAT Hrh1 Histamine H1 receptor 1.191e-06 0.39
ACHA_TETCF CHRNA1 Acetylcholine receptor subunit alpha 1.981e-06 0.34
5HT1D_HUMAN HTR1D 5-hydroxytryptamine receptor 1D 2.276e-06 0.30
ADA1A_RABIT ADRA1A Alpha-1A adrenergic receptor 2.764e-06 0.29
LSS_RAT Lss Lanosterol synthase 2.774e-06 0.31
OPRM_HUMAN OPRM1 Mu-type opioid receptor 3.031e-06 0.35
ADRB2_HUMAN ADRB2 Beta-2 adrenergic receptor 3.727e-06 0.31
DRD2_CHLAE DRD2 D(2) dopamine receptor 4.347e-06 0.34
OPRD_HUMAN OPRD1 Delta-type opioid receptor 4.484e-06 0.35
NR1H4_HUMAN NR1H4 Bile acid receptor 4.721e-06 0.32
NR1H4_MOUSE Nr1h4 Bile acid receptor 5.567e-06 0.28
VACHT_RAT Slc18a3 Vesicular acetylcholine transporter 6.952e-06 0.37
ADA1A_BOVIN ADRA1A Alpha-1A adrenergic receptor 7.477e-06 0.39
OPRK_CAVPO OPRK1 Kappa-type opioid receptor 9.059e-06 0.32

Istradefylline

AA2AR_RAT Adora2a Adenosine receptor A2a 9.24e-50 1.00
AA1R_RAT Adora1 Adenosine receptor A1 3.987e-47 1.00
AA2BR_HUMAN ADORA2B Adenosine receptor A2b 3.031e-14 1.00
AA2AR_HUMAN ADORA2A Adenosine receptor A2a 1.842e-10 1.00
AA3R_HUMAN ADORA3 Adenosine receptor A3 1.528e-09 1.00
AA1R_HUMAN ADORA1 Adenosine receptor A1 3.765e-05 1.00
TBB1_HUMAN TUBB1 Tubulin beta-1 chain 1.07e-64 0.37
AA1R_CAVPO ADORA1 Adenosine receptor A1 4.067e-42 0.84
CP1A1_HUMAN CYP1A1 Cytochrome P450 1A1 2.098e-39 0.40
TGM3_HUMAN TGM3 Protein-glutamine gamma-glutamyltransferase E 5.953e-37 0.29
MDR1B_MOUSE Abcb1b ATP-dependent translocase ABCB1 2.035e-27 0.32
CHIB1_ASPFM chiB1 Endochitinase B1 1.563e-26 0.30
AA2AR_CAVPO ADORA2A Adenosine receptor A2a 2.454e-21 0.32
TOP2A_HUMAN TOP2A DNA topoisomerase 2-alpha 4.816e-20 0.31
CP1B1_HUMAN CYP1B1 Cytochrome P450 1B1 8.822e-20 0.40
ERO1A_HUMAN ERO1A ERO1-like protein alpha 9.314e-20 0.31
A4_HUMAN APP Amyloid-beta precursor protein 3.366e-19 0.33
CYSP_PLAFA Trophozoite cysteine proteinase 5.587e-19 0.37
MTSI_SPISQ sssIM CPG DNA methylase 4.011e-18 0.31
PGH2_RAT Ptgs2 Prostaglandin G/H synthase 2 1.646e-17 0.31
NF2L2_HUMAN NFE2L2 Nuclear factor erythroid 2-related factor 2 2.22e-16 0.38
TRPM5_HUMAN TRPM5 Transient receptor potential cation channel subfamily M member 5 2.442e-15 0.31
ABCG2_HUMAN ABCG2 Broad substrate specificity ATP-binding cassette transporter ABCG2 1.426e-13 0.36
PDE5A_HUMAN PDE5A cGMP-specific 3',5'-cyclic phosphodiesterase 1.857e-13 0.45
LGUL_HUMAN GLO1 Lactoylglutathione lyase 2.28e-13 0.34
TIF1A_HUMAN TRIM24 Transcription intermediary factor 1-alpha 2.887e-13 0.32
CYSK_MYCTU cysK1 O-acetylserine sulfhydrylase 3.345e-13 0.31
NEMO_HUMAN IKBKG NF-kappa-B essential modulator 6.291e-13 0.34
Q8HY88_BOVIN KCNK2 Potassium channel subfamily K member 2 1.761e-12 0.31
AK1A1_PIG AKR1A1 Aldo-keto reductase family 1 member A1 2.757e-12 0.30
NFKB1_HUMAN NFKB1 Nuclear factor NF-kappa-B p105 subunit 1.619e-11 0.35
ODP2_MYCTU dlaT Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex 3.653e-11 0.34
SDF1_HUMAN CXCL12 Stromal cell-derived factor 1 7.379e-11 0.28
BRPF3_HUMAN BRPF3 Bromodomain and PHD finger-containing protein 3 2.909e-10 0.32
DYR1A_MOUSE Dyrk1a Dual specificity tyrosine-phosphorylation-regulated kinase 1A 7.541e-10 0.29
S100B_HUMAN S100B Protein S100-B 7.541e-10 0.29
PDE10_MOUSE Pde10a cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 1.713e-09 0.30
BRD1_HUMAN BRD1 Bromodomain-containing protein 1 3.388e-09 0.32
AOFB_HUMAN MAOB Amine oxidase [flavin-containing] B 3.981e-09 0.52
MRP1_HUMAN ABCC1 Multidrug resistance-associated protein 1 7.947e-09 0.32
TNFA_HUMAN TNF Tumor necrosis factor 8.043e-09 0.41
NQO2_HUMAN NQO2 Ribosyldihydronicotinamide dehydrogenase [quinone] 1.314e-08 0.40
AA1R_BOVIN ADORA1 Adenosine receptor A1 1.328e-08 0.37
TAU_BOVIN MAPT Microtubule-associated protein tau 4.951e-08 0.28
DHB3_RAT Hsd17b3 Testosterone 17-beta-dehydrogenase 3 8.438e-08 0.31
DCOR_HUMAN ODC1 Ornithine decarboxylase 9.132e-08 0.29
TAU_HUMAN MAPT Microtubule-associated protein tau 1.059e-07 0.31
NCOA3_HUMAN NCOA3 Nuclear receptor coactivator 3 1.434e-07 0.34
TLR4_HUMAN TLR4 Toll-like receptor 4 2.04e-07 0.31
TBB2B_BOVIN TUBB2B Tubulin beta-2B chain 4.163e-07 0.37
TNR1A_HUMAN TNFRSF1A Tumor necrosis factor receptor superfamily member 1A 1.777e-06 0.31
VP16_HHV11 Tegument protein VP16 4.64e-06 0.34
BRPF1_HUMAN BRPF1 Peregrin 8.82e-06 0.32

Pacritinib

FLT3_HUMAN FLT3 Receptor-type tyrosine-protein kinase FLT3 7.223e-47 1.00
TYK2_HUMAN TYK2 Non-receptor tyrosine-protein kinase TYK2 2.879e-40 1.00
JAK2_HUMAN JAK2 Tyrosine-protein kinase JAK2 1.507e-32 1.00
JAK3_HUMAN JAK3 Tyrosine-protein kinase JAK3 3.331e-16 1.00
JAK1_HUMAN JAK1 Tyrosine-protein kinase JAK1 7.216e-15 1.00
LKHA4_HUMAN LTA4H Leukotriene A-4 hydrolase 3.686e-31 0.34
NORA_STAAU norA Quinolone resistance protein NorA 1.802e-18 0.33
MCHR1_HUMAN MCHR1 Melanin-concentrating hormone receptor 1 5.892e-18 0.39
ROCK2_RAT Rock2 Rho-associated protein kinase 2 1.665e-15 0.32
5HT2C_HUMAN HTR2C 5-hydroxytryptamine receptor 2C 1.124e-12 0.33
TRPM2_HUMAN TRPM2 Transient receptor potential cation channel subfamily M member 2 2.757e-12 0.30
5HT2B_HUMAN HTR2B 5-hydroxytryptamine receptor 2B 4.746e-12 0.33
JAK3_MOUSE Jak3 Tyrosine-protein kinase JAK3 1.429e-10 0.31
5HT2A_HUMAN HTR2A 5-hydroxytryptamine receptor 2A 1.177e-09 0.33
MAT1_HUMAN MNAT1 CDK-activating kinase assembly factor MAT1 3.762e-08 0.40
CDK2_HUMAN CDK2 Cyclin-dependent kinase 2 1.606e-07 0.81
HDAC6_HUMAN HDAC6 Histone deacetylase 6 1.973e-07 0.80
LKHA4_MOUSE Lta4h Leukotriene A-4 hydrolase 7.311e-07 0.34
KMO_HUMAN KMO Kynurenine 3-monooxygenase 1.09e-06 0.39
TLR9_HUMAN TLR9 Toll-like receptor 9 2.017e-06 0.30
ACK1_HUMAN TNK2 Activated CDC42 kinase 1 4.115e-06 0.32
CPT1A_RAT Cpt1a Carnitine O-palmitoyltransferase 1, liver isoform 6.081e-06 0.30
CPT1A_HUMAN CPT1A Carnitine O-palmitoyltransferase 1, liver isoform 7.526e-06 0.30

Encorafenib

BRAF_HUMAN BRAF Serine/threonine-protein kinase B-raf 2.408e-45 1.00
MK14_HUMAN MAPK14 Mitogen-activated protein kinase 14 0.3214 1.00
NMDZ1_MOUSE Grin1 Glutamate receptor ionotropic, NMDA 1 2.435e-37 0.30
A6QR73_RAT Gpr39 G protein-coupled receptor 39 2.235e-23 0.30
BCR_HUMAN BCR Breakpoint cluster region protein 9.056e-18 0.28
TRPV1_HUMAN TRPV1 Transient receptor potential cation channel subfamily V member 1 3.889e-06 0.32

Apalutamide

ANDR_HUMAN AR Androgen receptor 8.611e-42 1.00
PRGR_RAT Pgr Progesterone receptor 6.108e-13 0.28

Momelotinib

JAK2_MOUSE Jak2 Tyrosine-protein kinase JAK2 4.629e-39 1.00
JAK2_HUMAN JAK2 Tyrosine-protein kinase JAK2 1.263e-38 1.00
JAK3_HUMAN JAK3 Tyrosine-protein kinase JAK3 4.13e-38 1.00
BMR1A_HUMAN BMPR1A Bone morphogenetic protein receptor type-1A 1.377e-17 1.00
BMR1B_HUMAN BMPR1B Bone morphogenetic protein receptor type-1B 4.142e-12 1.00
ACVR1_HUMAN ACVR1 Activin receptor type-1 1.197e-10 1.00
JAK1_HUMAN JAK1 Tyrosine-protein kinase JAK1 1.256e-08 1.00
TGFR1_HUMAN TGFBR1 TGF-beta receptor type-1 0.0001316 1.00
IKKE_HUMAN IKBKE Inhibitor of nuclear factor kappa-B kinase subunit epsilon 7.807e-217 0.58
TBK1_HUMAN TBK1 Serine/threonine-protein kinase TBK1 2.784e-199 0.58
SMG1_HUMAN SMG1 Serine/threonine-protein kinase SMG1 3.278e-141 0.49
KSYK_HUMAN SYK Tyrosine-protein kinase SYK 4.732e-109 0.49
STAT6_HUMAN STAT6 Signal transducer and activator of transcription 6 1.163e-100 0.42
CATK_RABIT CTSK Cathepsin K 1.296e-97 0.49
NEMO_HUMAN IKBKG NF-kappa-B essential modulator 1.117e-96 0.42
CCND2_HUMAN CCND2 G1/S-specific cyclin-D2 1.004e-85 0.37
PRIO_SHEEP PRNP Major prion protein 2.832e-81 0.41
MTOR_HUMAN MTOR Serine/threonine-protein kinase mTOR 4.914e-76 0.46
INSR_HUMAN INSR Insulin receptor 9.369e-68 0.49
BCR_HUMAN BCR Breakpoint cluster region protein 1.883e-58 0.37
CCND3_HUMAN CCND3 G1/S-specific cyclin-D3 1.11e-57 0.42
IGF1R_HUMAN IGF1R Insulin-like growth factor 1 receptor 1.163e-57 0.47
MK10_HUMAN MAPK10 Mitogen-activated protein kinase 10 2.765e-54 0.53
CDK4_HUMAN CDK4 Cyclin-dependent kinase 4 1.85e-52 0.51
MTOR_RAT Mtor Serine/threonine-protein kinase mTOR 8.867e-52 0.34
CDK2_HUMAN CDK2 Cyclin-dependent kinase 2 8.981e-51 0.51
CCND1_HUMAN CCND1 G1/S-specific cyclin-D1 9.627e-51 0.41
JAK3_MOUSE Jak3 Tyrosine-protein kinase JAK3 1.116e-49 0.51
IKKB_HUMAN IKBKB Inhibitor of nuclear factor kappa-B kinase subunit beta 5.296e-48 0.56
IKKA_HUMAN CHUK Inhibitor of nuclear factor kappa-B kinase subunit alpha 1.583e-47 0.45
RAF1_HUMAN RAF1 RAF proto-oncogene serine/threonine-protein kinase 1.775e-46 0.38
PK3CA_HUMAN PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 1.978e-46 0.41
ERBB2_HUMAN ERBB2 Receptor tyrosine-protein kinase erbB-2 2.277e-42 0.47
FAK1_HUMAN PTK2 Focal adhesion kinase 1 2.841e-38 0.47
MAPK5_HUMAN MAPKAPK5 MAP kinase-activated protein kinase 5 2.99e-38 0.40
SHH_MOUSE Shh Sonic hedgehog protein 1.677e-37 0.51
PK3CG_HUMAN PIK3CG Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 1.466e-36 0.41
ZAP70_HUMAN ZAP70 Tyrosine-protein kinase ZAP-70 1.717e-36 0.47
DKK1_HUMAN DKK1 Dickkopf-related protein 1 3.016e-36 0.33
HSPB1_HUMAN HSPB1 Heat shock protein beta-1 2.809e-35 0.40
AURKA_HUMAN AURKA Aurora kinase A 2.909e-34 0.51
BRAF_HUMAN BRAF Serine/threonine-protein kinase B-raf 1.068e-33 0.38
MK08_HUMAN MAPK8 Mitogen-activated protein kinase 8 1.86e-32 0.53
PGFRA_HUMAN PDGFRA Platelet-derived growth factor receptor alpha 2.559e-32 0.56
CATB_HUMAN CTSB Cathepsin B 2.625e-32 0.49
CDK1_HUMAN CDK1 Cyclin-dependent kinase 1 3.917e-32 0.49
CCNA2_HUMAN CCNA2 Cyclin-A2 5.989e-32 0.42
SO2A1_RAT Slco2a1 Solute carrier organic anion transporter family member 2A1 1.491e-31 0.31
CCNH_HUMAN CCNH Cyclin-H 2.113e-31 0.37
CCNB1_HUMAN CCNB1 G2/mitotic-specific cyclin-B1 3.045e-31 0.39
LRRK2_HUMAN LRRK2 Leucine-rich repeat serine/threonine-protein kinase 2 6.599e-31 0.42
CDK7_HUMAN CDK7 Cyclin-dependent kinase 7 5.269e-30 0.44
MK10_RAT Mapk10 Mitogen-activated protein kinase 10 1.357e-29 0.48
EPHB4_HUMAN EPHB4 Ephrin type-B receptor 4 3.627e-29 0.39
HPGDS_HUMAN HPGDS Hematopoietic prostaglandin D synthase 9.277e-28 0.43
FLT3_HUMAN FLT3 Receptor-type tyrosine-protein kinase FLT3 3.951e-27 0.56
MP2K1_HUMAN MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 4.743e-27 0.42
KIT_HUMAN KIT Mast/stem cell growth factor receptor Kit 5.208e-27 0.56
FAK2_HUMAN PTK2B Protein-tyrosine kinase 2-beta 1.779e-26 0.40
MK14_HUMAN MAPK14 Mitogen-activated protein kinase 14 2.114e-26 0.42
KPCD1_HUMAN PRKD1 Serine/threonine-protein kinase D1 2.981e-26 0.44
MK09_HUMAN MAPK9 Mitogen-activated protein kinase 9 5.624e-26 0.49
EGFR_HUMAN EGFR Epidermal growth factor receptor 1.688e-25 0.49
LCK_HUMAN LCK Tyrosine-protein kinase Lck 5.05e-25 0.49
CCNA1_HUMAN CCNA1 Cyclin-A1 1.004e-24 0.39
CCNE2_HUMAN CCNE2 G1/S-specific cyclin-E2 2.154e-24 0.37
NCOR1_HUMAN NCOR1 Nuclear receptor corepressor 1 2.297e-24 0.35
ABL1_HUMAN ABL1 Tyrosine-protein kinase ABL1 2.806e-24 0.49
PRKDC_MOUSE Prkdc DNA-dependent protein kinase catalytic subunit 2.826e-24 0.30
ALK_HUMAN ALK ALK tyrosine kinase receptor 6.099e-24 0.42
KCC2D_HUMAN CAMK2D Calcium/calmodulin-dependent protein kinase type II subunit delta 7.886e-24 0.49
CCNB2_HUMAN CCNB2 G2/mitotic-specific cyclin-B2 2.449e-23 0.37
CCNB3_HUMAN CCNB3 G2/mitotic-specific cyclin-B3 2.449e-23 0.37
Q4DCQ3_TRYCC Superoxide dismutase 5.518e-23 0.28
RIPK1_MOUSE Ripk1 Receptor-interacting serine/threonine-protein kinase 1 7.023e-23 0.35
TLR9_HUMAN TLR9 Toll-like receptor 9 2.922e-22 0.36
JUN_HUMAN JUN Transcription factor AP-1 1.123e-21 0.37
ABL1_MOUSE Abl1 Tyrosine-protein kinase ABL1 2.545e-21 0.38
MP2K1_MOUSE Map2k1 Dual specificity mitogen-activated protein kinase kinase 1 6.654e-21 0.33
ACK1_HUMAN TNK2 Activated CDC42 kinase 1 1.372e-20 0.49
TNIK_HUMAN TNIK TRAF2 and NCK-interacting protein kinase 2.965e-20 0.41
AUKBA_XENLA aurkb-a Aurora kinase B-A 3.102e-20 0.32
VGFR2_HUMAN KDR Vascular endothelial growth factor receptor 2 5.412e-20 0.56
BTK_MOUSE Btk Tyrosine-protein kinase BTK 7.437e-20 0.32
HIPK1_HUMAN HIPK1 Homeodomain-interacting protein kinase 1 9.422e-20 0.39
PMYT1_HUMAN PKMYT1 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase 9.98e-20 0.42
BTK_HUMAN BTK Tyrosine-protein kinase BTK 1.685e-19 0.46
PGFRB_HUMAN PDGFRB Platelet-derived growth factor receptor beta 2.401e-19 0.56
TTK_HUMAN TTK Dual specificity protein kinase TTK 2.706e-19 0.38
Q6DMN0_TOXGO CPL Cathepsin L 4.301e-19 0.29
M3K7_HUMAN MAP3K7 Mitogen-activated protein kinase kinase kinase 7 6.158e-19 0.39
CD63_HUMAN CD63 CD63 antigen 6.972e-19 0.35
SRC_HUMAN SRC Proto-oncogene tyrosine-protein kinase Src 1.664e-18 0.49
PAK1_HUMAN PAK1 Serine/threonine-protein kinase PAK 1 1.781e-18 0.43
LTK_HUMAN LTK Leukocyte tyrosine kinase receptor 2.273e-18 0.49
CATS_MOUSE Ctss Cathepsin S 2.838e-18 0.49
CATL1_HUMAN CTSL Cathepsin L1 2.972e-18 0.43
HGFL_HUMAN MST1 Hepatocyte growth factor-like protein 3.028e-18 0.29
AURKB_HUMAN AURKB Aurora kinase B 3.414e-18 0.51
PLK1_HUMAN PLK1 Serine/threonine-protein kinase PLK1 5.291e-18 0.45
TBK1_MOUSE Tbk1 Serine/threonine-protein kinase TBK1 2.497e-17 0.39
MP2K2_HUMAN MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 2.749e-17 0.42
CATS_HUMAN CTSS Cathepsin S 4.437e-17 0.49
RET_HUMAN RET Proto-oncogene tyrosine-protein kinase receptor Ret 4.755e-17 0.49
P85A_HUMAN PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha 4.759e-17 0.40
PK3C3_HUMAN PIK3C3 Phosphatidylinositol 3-kinase catalytic subunit type 3 1.11e-16 0.32
TAOK1_HUMAN TAOK1 Serine/threonine-protein kinase TAO1 1.11e-16 0.49
BPTF_HUMAN BPTF Nucleosome-remodeling factor subunit BPTF 2.22e-16 0.31
PDE10_RAT Pde10a cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 3.331e-16 0.34
CDK9_HUMAN CDK9 Cyclin-dependent kinase 9 5.551e-16 0.49
SCNAA_MOUSE Scn10a Sodium channel protein type 10 subunit alpha 1.665e-15 0.36
DYR1B_HUMAN DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B 1.998e-15 0.42
GSK3B_HUMAN GSK3B Glycogen synthase kinase-3 beta 2.22e-15 0.49
CSF1R_HUMAN CSF1R Macrophage colony-stimulating factor 1 receptor 3.442e-15 0.49
5HT1B_GORGO HTR1B 5-hydroxytryptamine receptor 1B 3.664e-15 0.29
FYN_HUMAN FYN Tyrosine-protein kinase Fyn 6.661e-15 0.49
NAMPT_HUMAN NAMPT Nicotinamide phosphoribosyltransferase 7.772e-15 0.41
CATK_HUMAN CTSK Cathepsin K 1.044e-14 0.49
CCNT1_HUMAN CCNT1 Cyclin-T1 1.166e-14 0.40
Q9HUN3_PSEAE dnaB Replicative DNA helicase 1.243e-14 0.32
O97467_PLAFA ht1 Hexose transporter 1 2.52e-14 0.42
M4K5_HUMAN MAP4K5 Mitogen-activated protein kinase kinase kinase kinase 5 3.053e-14 0.49
LYN_HUMAN LYN Tyrosine-protein kinase Lyn 3.764e-14 0.49
CDK6_HUMAN CDK6 Cyclin-dependent kinase 6 4.108e-14 0.42
VGFR1_HUMAN FLT1 Vascular endothelial growth factor receptor 1 9.304e-14 0.56
RON_HUMAN MST1R Macrophage-stimulating protein receptor 1.154e-13 0.42
CDKL1_HUMAN CDKL1 Cyclin-dependent kinase-like 1 1.203e-13 0.30
Q9WKE8_9HIV1 reverse transcriptase Reverse transcriptase 2.021e-13 0.36
WEE1_HUMAN WEE1 Wee1-like protein kinase 2.22e-13 0.49
GSK3A_HUMAN GSK3A Glycogen synthase kinase-3 alpha 2.559e-13 0.49
CCNE1_HUMAN CCNE1 G1/S-specific cyclin-E1 3.498e-13 0.40
DRD4_RAT Drd4 D(4) dopamine receptor 4.265e-13 0.36
GTR1_HUMAN SLC2A1 Solute carrier family 2, facilitated glucose transporter member 1 6.576e-13 0.42
FGFR1_HUMAN FGFR1 Fibroblast growth factor receptor 1 1.111e-12 0.49
KC1D_HUMAN CSNK1D Casein kinase I isoform delta 1.138e-12 0.49
M4K2_HUMAN MAP4K2 Mitogen-activated protein kinase kinase kinase kinase 2 1.228e-12 0.49
O61059_LEIME LmGT2 Glucose transporter 1.275e-12 0.42
YES_HUMAN YES1 Tyrosine-protein kinase Yes 1.278e-12 0.43
DAPK3_HUMAN DAPK3 Death-associated protein kinase 3 1.384e-12 0.49
INCE_HUMAN INCENP Inner centromere protein 1.86e-12 0.38
PE2R2_HUMAN PTGER2 Prostaglandin E2 receptor EP2 subtype 1.915e-12 0.39
KSYK_RAT Syk Tyrosine-protein kinase SYK 2.492e-12 0.33
HDAC1_HUMAN HDAC1 Histone deacetylase 1 3.102e-12 0.45
KPCD3_HUMAN PRKD3 Serine/threonine-protein kinase D3 3.434e-12 0.49
CHK1_HUMAN CHEK1 Serine/threonine-protein kinase Chk1 4.084e-12 0.49
CLK2_HUMAN CLK2 Dual specificity protein kinase CLK2 4.387e-12 0.49
ROS1_HUMAN ROS1 Proto-oncogene tyrosine-protein kinase ROS 4.955e-12 0.49
DGAT1_HUMAN DGAT1 Diacylglycerol O-acyltransferase 1 5.679e-12 0.38
DDR2_HUMAN DDR2 Discoidin domain-containing receptor 2 6.16e-12 0.38
S47A2_HUMAN SLC47A2 Multidrug and toxin extrusion protein 2 6.448e-12 0.38
O96526_LEIMA CRK3 Cdc2-related kinase 7.229e-12 0.35
M3K20_HUMAN MAP3K20 Mitogen-activated protein kinase kinase kinase 20 7.422e-12 0.49
PK3CB_HUMAN PIK3CB Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 8.093e-12 0.41
KC1E_HUMAN CSNK1E Casein kinase I isoform epsilon 8.335e-12 0.32
CLK4_HUMAN CLK4 Dual specificity protein kinase CLK4 1.756e-11 0.49
KIT_MOUSE Kit Mast/stem cell growth factor receptor Kit 2.335e-11 0.33
AAPK1_HUMAN PRKAA1 5'-AMP-activated protein kinase catalytic subunit alpha-1 3.487e-11 0.49
PAK4_HUMAN PAK4 Serine/threonine-protein kinase PAK 4 4.208e-11 0.49
M4K4_HUMAN MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4 5.018e-11 0.49
NTRK2_HUMAN NTRK2 BDNF/NT-3 growth factors receptor 5.744e-11 0.42
STK3_HUMAN STK3 Serine/threonine-protein kinase 3 5.864e-11 0.49
FRK_HUMAN FRK Tyrosine-protein kinase FRK 8.192e-11 0.49
GSK3B_RAT Gsk3b Glycogen synthase kinase-3 beta 1.212e-10 0.29
SEPR_MOUSE Fap Prolyl endopeptidase FAP 1.291e-10 0.31
HIPK4_HUMAN HIPK4 Homeodomain-interacting protein kinase 4 1.564e-10 0.49
TYK2_HUMAN TYK2 Non-receptor tyrosine-protein kinase TYK2 2.384e-10 0.56
RAC1_HUMAN RAC1 Ras-related C3 botulinum toxin substrate 1 2.891e-10 0.30
CSN5_HUMAN COPS5 COP9 signalosome complex subunit 5 3.926e-10 0.34
KC1A_HUMAN CSNK1A1 Casein kinase I isoform alpha 4.031e-10 0.49
KS6A3_HUMAN RPS6KA3 Ribosomal protein S6 kinase alpha-3 4.395e-10 0.49
PYGM_HUMAN PYGM Glycogen phosphorylase, muscle form 4.56e-10 0.34
LCK_MOUSE Lck Proto-oncogene tyrosine-protein kinase LCK 5.568e-10 0.31
NEK2_HUMAN NEK2 Serine/threonine-protein kinase Nek2 7.757e-10 0.49
MK01_HUMAN MAPK1 Mitogen-activated protein kinase 1 8.097e-10 0.39
EPHA8_HUMAN EPHA8 Ephrin type-A receptor 8 1.233e-09 0.38
AK1C3_HUMAN AKR1C3 Aldo-keto reductase family 1 member C3 1.475e-09 0.33
CETP_HUMAN CETP Cholesteryl ester transfer protein 1.477e-09 0.35
SRMS_HUMAN SRMS Tyrosine-protein kinase Srms 2.774e-09 0.39
TYRO3_HUMAN TYRO3 Tyrosine-protein kinase receptor TYRO3 5.443e-09 0.42
PGH1_SHEEP PTGS1 Prostaglandin G/H synthase 1 6.291e-09 0.43
NTRK3_HUMAN NTRK3 NT-3 growth factor receptor 7.178e-09 0.49
PDGFB_HUMAN PDGFB Platelet-derived growth factor subunit B 7.807e-09 0.48
SLK_HUMAN SLK STE20-like serine/threonine-protein kinase 8.584e-09 0.49
NK2R_MESAU TACR2 Substance-K receptor 9.622e-09 0.34
DRD3_HUMAN DRD3 D(3) dopamine receptor 1.059e-08 0.39
PK3CD_HUMAN PIK3CD Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 1.259e-08 0.36
KCC2A_HUMAN CAMK2A Calcium/calmodulin-dependent protein kinase type II subunit alpha 1.682e-08 0.49
KLK6_HUMAN KLK6 Kallikrein-6 1.968e-08 0.30
PDE10_HUMAN PDE10A cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 2.185e-08 0.34
AOC3_RAT Aoc3 Membrane primary amine oxidase 2.245e-08 0.38
EPHB3_HUMAN EPHB3 Ephrin type-B receptor 3 2.417e-08 0.31
CDK19_HUMAN CDK19 Cyclin-dependent kinase 19 2.575e-08 0.47
MARK3_HUMAN MARK3 MAP/microtubule affinity-regulating kinase 3 2.873e-08 0.49
PHKG2_HUMAN PHKG2 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 2.929e-08 0.49
AURKC_HUMAN AURKC Aurora kinase C 2.952e-08 0.49
MAPK2_HUMAN MAPKAPK2 MAP kinase-activated protein kinase 2 3.227e-08 0.32
HDAC3_HUMAN HDAC3 Histone deacetylase 3 3.334e-08 0.38
GSK3B_MOUSE Gsk3b Glycogen synthase kinase-3 beta 4.067e-08 0.30
NCOR2_HUMAN NCOR2 Nuclear receptor corepressor 2 5.632e-08 0.33
KPCD2_HUMAN PRKD2 Serine/threonine-protein kinase D2 6.027e-08 0.49
BRSK2_HUMAN BRSK2 Serine/threonine-protein kinase BRSK2 6.311e-08 0.39
FER_HUMAN FER Tyrosine-protein kinase Fer 7.456e-08 0.49
ERBB4_HUMAN ERBB4 Receptor tyrosine-protein kinase erbB-4 8.331e-08 0.43
REV1_HUMAN REV1 DNA repair protein REV1 8.352e-08 0.29
MRCKB_HUMAN CDC42BPB Serine/threonine-protein kinase MRCK beta 8.359e-08 0.31
EPHA6_HUMAN EPHA6 Ephrin type-A receptor 6 8.702e-08 0.31
HDAC8_HUMAN HDAC8 Histone deacetylase 8 9.53e-08 0.39
RIPK2_HUMAN RIPK2 Receptor-interacting serine/threonine-protein kinase 2 9.568e-08 0.32
DYR1A_HUMAN DYRK1A Dual specificity tyrosine-phosphorylation-regulated kinase 1A 1.001e-07 0.49
AOC3_HUMAN AOC3 Membrane primary amine oxidase 1.187e-07 0.38
SCNAA_HUMAN SCN10A Sodium channel protein type 10 subunit alpha 1.383e-07 0.36
BLK_HUMAN BLK Tyrosine-protein kinase Blk 1.705e-07 0.49
M3K9_HUMAN MAP3K9 Mitogen-activated protein kinase kinase kinase 9 1.923e-07 0.56
TIE1_HUMAN TIE1 Tyrosine-protein kinase receptor Tie-1 2.004e-07 0.31
WEE2_HUMAN WEE2 Wee1-like protein kinase 2 2.004e-07 0.32
AVR2B_HUMAN ACVR2B Activin receptor type-2B 2.173e-07 0.34
FES_HUMAN FES Tyrosine-protein kinase Fes/Fps 2.606e-07 0.43
DDR1_HUMAN DDR1 Epithelial discoidin domain-containing receptor 1 3.563e-07 0.38
EPHB6_HUMAN EPHB6 Ephrin type-B receptor 6 4.193e-07 0.31
ACHA7_RAT Chrna7 Neuronal acetylcholine receptor subunit alpha-7 4.253e-07 0.36
TNNC1_HUMAN TNNC1 Troponin C, slow skeletal and cardiac muscles 4.29e-07 0.31
TNNI3_HUMAN TNNI3 Troponin I, cardiac muscle 4.29e-07 0.31
TNNT2_HUMAN TNNT2 Troponin T, cardiac muscle 4.29e-07 0.31
ABL2_HUMAN ABL2 Tyrosine-protein kinase ABL2 5.205e-07 0.38
5HT1D_CAVPO HTR1D 5-hydroxytryptamine receptor 1D 7.227e-07 0.29
ADRB2_CANLF ADRB2 Beta-2 adrenergic receptor 7.374e-07 0.29
ITK_HUMAN ITK Tyrosine-protein kinase ITK/TSK 8.692e-07 0.49
UFO_HUMAN AXL Tyrosine-protein kinase receptor UFO 8.852e-07 0.43
AOFA_RAT Maoa Amine oxidase [flavin-containing] A 1.124e-06 0.34
STABP_HUMAN STAMBP STAM-binding protein 1.136e-06 0.34
NEK6_HUMAN NEK6 Serine/threonine-protein kinase Nek6 1.166e-06 0.32
CLK1_HUMAN CLK1 Dual specificity protein kinase CLK1 1.189e-06 0.40
ERN1_HUMAN ERN1 Serine/threonine-protein kinase/endoribonuclease IRE1 1.317e-06 0.38
S22A2_HUMAN SLC22A2 Solute carrier family 22 member 2 1.428e-06 0.38
SCN2A_HUMAN SCN2A Sodium channel protein type 2 subunit alpha 1.474e-06 0.33
STK10_HUMAN STK10 Serine/threonine-protein kinase 10 1.763e-06 0.31
P3C2B_HUMAN PIK3C2B Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta 1.954e-06 0.32
PLK4_HUMAN PLK4 Serine/threonine-protein kinase PLK4 1.962e-06 0.49
EPHA3_HUMAN EPHA3 Ephrin type-A receptor 3 2.107e-06 0.31
SCN9A_HUMAN SCN9A Sodium channel protein type 9 subunit alpha 2.208e-06 0.38
DPOL_VACCW POL DNA polymerase 2.423e-06 0.31
KCC2B_HUMAN CAMK2B Calcium/calmodulin-dependent protein kinase type II subunit beta 2.505e-06 0.49
HDAC2_HUMAN HDAC2 Histone deacetylase 2 2.868e-06 0.38
S47A1_HUMAN SLC47A1 Multidrug and toxin extrusion protein 1 2.891e-06 0.38
5HT2A_HUMAN HTR2A 5-hydroxytryptamine receptor 2A 2.894e-06 0.38
MYLK3_HUMAN MYLK3 Myosin light chain kinase 3 3.052e-06 0.31
Q8I5C5_PLAF7 Macrophage migration inhibitory factor 3.105e-06 0.28
ERCC1_HUMAN ERCC1 DNA excision repair protein ERCC-1 3.301e-06 0.32
XPF_HUMAN ERCC4 DNA repair endonuclease XPF 3.301e-06 0.32
RCOR1_HUMAN RCOR1 REST corepressor 1 3.571e-06 0.37
PAPA1_CARPA Papain 3.595e-06 0.31
5HT1A_RAT Htr1a 5-hydroxytryptamine receptor 1A 3.626e-06 0.38
CAH3_HUMAN CA3 Carbonic anhydrase 3 4.083e-06 0.38
PI42C_HUMAN PIP4K2C Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma 4.083e-06 0.38
KCC2G_HUMAN CAMK2G Calcium/calmodulin-dependent protein kinase type II subunit gamma 4.107e-06 0.49
VGFR3_HUMAN FLT4 Vascular endothelial growth factor receptor 3 5.499e-06 0.56
KAPCA_HUMAN PRKACA cAMP-dependent protein kinase catalytic subunit alpha 6.431e-06 0.49
CDK5_HUMAN CDK5 Cyclin-dependent-like kinase 5 6.717e-06 0.49
DRD2_HUMAN DRD2 D(2) dopamine receptor 6.814e-06 0.39
PTGDS_MOUSE Ptgds Prostaglandin-H2 D-isomerase 8.543e-06 0.29
ROCK1_HUMAN ROCK1 Rho-associated protein kinase 1 8.672e-06 0.49
FA10_HUMAN F10 Coagulation factor X 9.087e-06 0.34
A1Z199_HUMAN BCR/ABL fusion BCR/ABL p210 fusion protein 9.374e-06 0.38
MINK1_HUMAN MINK1 Misshapen-like kinase 1 9.461e-06 0.38
FGR_HUMAN FGR Tyrosine-protein kinase Fgr 9.58e-06 0.38
P96830_MYCTO TYR_PHOSPHATASE_2 domain-containing protein 9.991e-06 0.29

Ponesimod

S1PR3_HUMAN S1PR3 Sphingosine 1-phosphate receptor 3 1.618e-36 1.00
S1PR1_HUMAN S1PR1 Sphingosine 1-phosphate receptor 1 9.924e-20 1.00
S1PR4_HUMAN S1PR4 Sphingosine 1-phosphate receptor 4 5.996e-06 1.00
S1PR5_HUMAN S1PR5 Sphingosine 1-phosphate receptor 5 0.0002498 1.00
PMT1_CANAL PMT1 Dolichyl-phosphate-mannose--protein mannosyltransferase 1 1.801e-86 0.33
CYSK_MYCTU cysK1 O-acetylserine sulfhydrylase 1.015e-36 0.32
PGDH_HUMAN HPGD 15-hydroxyprostaglandin dehydrogenase [NAD(+)] 1.135e-27 0.35
ANDR_MOUSE Ar Androgen receptor 1.287e-26 0.31
PPAC_HUMAN ACP1 Low molecular weight phosphotyrosine protein phosphatase 4.48e-25 0.33
FA8_HUMAN F8 Coagulation factor VIII 1.605e-23 0.29
Q9AQH7_STAAU dnaC Replicative DNA helicase 2.603e-23 0.31
C4LW95_ENTHI Thioredoxin reductase 4.013e-21 0.31
PTN12_HUMAN PTPN12 Tyrosine-protein phosphatase non-receptor type 12 4.441e-16 0.35
RNT1_ASPOR rntA Guanyl-specific ribonuclease T1 4.553e-13 0.28
AK1A1_PIG AKR1A1 Aldo-keto reductase family 1 member A1 3.4e-12 0.30
ALDR_BOVIN AKR1B1 Aldo-keto reductase family 1 member B1 6.773e-12 0.30
Q5A7N4_CANAL TPT1 tRNA 2'-phosphotransferase 1.453e-08 0.28
Q965D5_PLAFA fabI Enoyl-acyl-carrier protein reductase 1.89e-08 0.30
CISD1_HUMAN CISD1 CDGSH iron-sulfur domain-containing protein 1 2.18e-08 0.33
MDR1_HUMAN ABCB1 ATP-dependent translocase ABCB1 4.938e-08 0.34
PTN2_HUMAN PTPN2 Tyrosine-protein phosphatase non-receptor type 2 4.095e-07 0.33
VDR_HUMAN VDR Vitamin D3 receptor 1.291e-06 0.30
PTN7_HUMAN PTPN7 Tyrosine-protein phosphatase non-receptor type 7 1.656e-06 0.35
DUS22_HUMAN DUSP22 Dual specificity protein phosphatase 22 5.752e-06 0.28

Tilarginine

NOS3_BOVIN NOS3 Nitric oxide synthase, endothelial 4.515e-35 1.00
NOS1_MOUSE Nos1 Nitric oxide synthase, brain 1.608e-27 1.00
NOS1_RAT Nos1 Nitric oxide synthase, brain 1.716e-25 1.00
NOS1_HUMAN NOS1 Nitric oxide synthase, brain 3.016e-24 1.00
NOS2_HUMAN NOS2 Nitric oxide synthase, inducible 2.302e-22 1.00
NOS3_HUMAN NOS3 Nitric oxide synthase, endothelial 1.019e-19 1.00
BHMT1_HUMAN BHMT Betaine--homocysteine S-methyltransferase 1 4.813e-85 0.36
GLN1B_ECOLI glnA Glutamine synthetase 8.643e-77 0.38
ARGI1_HUMAN ARG1 Arginase-1 2.884e-70 0.56
ARGI2_HUMAN ARG2 Arginase-2, mitochondrial 7.817e-70 0.56
OTC_HUMAN OTC Ornithine carbamoyltransferase, mitochondrial 8.012e-66 0.53
GSH1_HUMAN GCLC Glutamate--cysteine ligase catalytic subunit 4.388e-60 0.33
GSP_CRIFA GSP Glutathionylspermidine synthase 5.635e-59 0.32
CHIA_SERMA chiA Chitinase A 1.409e-53 0.41
GRIK3_RAT Grik3 Glutamate receptor ionotropic, kainate 3 1.506e-53 0.40
GRM8_MOUSE Grm8 Metabotropic glutamate receptor 8 3.077e-50 0.40
TPP2_HUMAN TPP2 Tripeptidyl-peptidase 2 9.43e-46 0.36
PAO1_MAIZE MPAO1 Polyamine oxidase 1 4.824e-45 0.32
ARGI1_RAT Arg1 Arginase-1 1.083e-44 0.56
BHMT2_HUMAN BHMT2 S-methylmethionine--homocysteine S-methyltransferase BHMT2 4.538e-44 0.35
AAA1_RAT Slc7a10 Asc-type amino acid transporter 1 2.679e-43 0.34
GRM8_RAT Grm8 Metabotropic glutamate receptor 8 5.388e-42 0.40
CA2D1_MOUSE Cacna2d1 Voltage-dependent calcium channel subunit alpha-2/delta-1 5.828e-42 0.38
GFPT1_HUMAN GFPT1 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 5.068e-41 0.34
AL1A2_CHICK ALDH1A2 Retinal dehydrogenase 2 1.381e-38 0.31
LUXS_ECOLI luxS S-ribosylhomocysteine lyase 1.947e-38 0.30
LUXS_VIBCB luxS S-ribosylhomocysteine lyase 1.947e-38 0.30
LAT1_HUMAN SLC7A5 Large neutral amino acids transporter small subunit 1 5.492e-38 0.33
GSTM1_HUMAN GSTM1 Glutathione S-transferase Mu 1 3.777e-37 0.31
DHAS_HELPY asd Aspartate-semialdehyde dehydrogenase 1.332e-36 0.29
AMPB_HUMAN RNPEP Aminopeptidase B 3.153e-35 0.34
DNPEP_HUMAN DNPEP Aspartyl aminopeptidase 1.946e-33 0.34
GRIK1_RAT Grik1 Glutamate receptor ionotropic, kainate 1 8.75e-32 0.40
GRIK1_HUMAN GRIK1 Glutamate receptor ionotropic, kainate 1 1.212e-31 0.35
LUXS_BACSU luxS S-ribosylhomocysteine lyase 1.258e-31 0.30
GRM6_RAT Grm6 Metabotropic glutamate receptor 6 4.215e-31 0.40
PCSK6_HUMAN PCSK6 Proprotein convertase subtilisin/kexin type 6 7.427e-31 0.33
GRIK2_RAT Grik2 Glutamate receptor ionotropic, kainate 2 8.208e-31 0.40
WDR5_HUMAN WDR5 WD repeat-containing protein 5 1.103e-25 0.35
GSTK1_HUMAN GSTK1 Glutathione S-transferase kappa 1 2.258e-25 0.31
S15A2_HUMAN SLC15A2 Solute carrier family 15 member 2 1.605e-23 0.29
FURIN_HUMAN FURIN Furin 7.579e-21 0.44
GRM4_RAT Grm4 Metabotropic glutamate receptor 4 1.091e-20 0.40
DPO1_THEAQ polA DNA polymerase I, thermostable 1.626e-20 0.34
CFAB_HUMAN CFB Complement factor B 3.066e-20 0.32
CHIB_SERMA chiB Chitinase B 3.88e-20 0.35
D5FGE8_TRYCR POT1.5 Putative amino acid permease/transporter 2.322e-19 0.31
VM1B1_BOTAS Snake venom metalloproteinase BaP1 3.333e-19 0.31
NOS2_RAT Nos2 Nitric oxide synthase, inducible 5.777e-19 0.42
VGLU3_RAT Slc17a8 Vesicular glutamate transporter 3 9.803e-19 0.30
GRIK2_HUMAN GRIK2 Glutamate receptor ionotropic, kainate 2 2.725e-18 0.35
GRIA1_MOUSE Gria1 Glutamate receptor 1 3.143e-18 0.29
NOD1_HUMAN NOD1 Nucleotide-binding oligomerization domain-containing protein 1 9.819e-18 0.42
C3AR_HUMAN C3AR1 C3a anaphylatoxin chemotactic receptor 1.445e-17 0.32
NOS2_MOUSE Nos2 Nitric oxide synthase, inducible 2.007e-17 0.73
O31048_PORGN DPP IV Dipeptidyl peptidase IV 1.11e-16 0.40
AMPB_RAT Rnpep Aminopeptidase B 2.22e-16 0.38
S15A1_HUMAN SLC15A1 Solute carrier family 15 member 1 6.328e-15 0.28
MRGX1_MOUSE Mrgprx1 Mas-related G-protein coupled receptor member X1 2.598e-14 0.35
NEP_MOUSE Mme Neprilysin 5.338e-13 0.28
GRIA3_RAT Gria3 Glutamate receptor 3 8.248e-13 0.30
GRIA3_HUMAN GRIA3 Glutamate receptor 3 9.271e-13 0.29
EAA3_HUMAN SLC1A1 Excitatory amino acid transporter 3 1.233e-12 0.34
GRIK5_HUMAN GRIK5 Glutamate receptor ionotropic, kainate 5 2.049e-11 0.33
AL1A3_HUMAN ALDH1A3 Aldehyde dehydrogenase family 1 member A3 2.276e-11 0.31
GRM6_HUMAN GRM6 Metabotropic glutamate receptor 6 3.792e-10 0.40
MCA2_TRYBB MCA2 Metacaspase 5.162e-10 0.29
NMDE1_RAT Grin2a Glutamate receptor ionotropic, NMDA 2A 5.734e-10 0.46
PADI1_HUMAN PADI1 Protein-arginine deiminase type-1 6.171e-10 0.29
PADI3_HUMAN PADI3 Protein-arginine deiminase type-3 6.171e-10 0.29
AL1A2_HUMAN ALDH1A2 Retinal dehydrogenase 2 9.414e-10 0.31
DDAH1_HUMAN DDAH1 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 1.513e-09 0.34
LGUL_HUMAN GLO1 Lactoylglutathione lyase 2.895e-09 0.30
GSTA1_HUMAN GSTA1 Glutathione S-transferase A1 5.111e-08 0.30
DCOR_HUMAN ODC1 Ornithine decarboxylase 1.266e-07 0.28
ERAP2_HUMAN ERAP2 Endoplasmic reticulum aminopeptidase 2 2.13e-07 0.35
GRIA2_RAT Gria2 Glutamate receptor 2 2.366e-07 0.33
GRIK3_HUMAN GRIK3 Glutamate receptor ionotropic, kainate 3 2.72e-07 0.33
NPFF2_HUMAN NPFFR2 Neuropeptide FF receptor 2 3.113e-07 0.33
GRM8_HUMAN GRM8 Metabotropic glutamate receptor 8 3.151e-07 0.40
GRIA1_HUMAN GRIA1 Glutamate receptor 1 4.822e-07 0.33
MRGX1_RAT Mrgprx1 Mas-related G-protein coupled receptor member X1 7.169e-07 0.35
TYTR_TRYCR TPR Trypanothione reductase 8.045e-07 0.30
PADI4_HUMAN PADI4 Protein-arginine deiminase type-4 8.227e-07 0.29
GRIA4_HUMAN GRIA4 Glutamate receptor 4 2.029e-06 0.33
TPP2_RAT Tpp2 Tripeptidyl-peptidase 2 2.345e-06 0.36

Estetrol

ESR1_HUMAN ESR1 Estrogen receptor 1.048e-34 1.00
ESR2_HUMAN ESR2 Estrogen receptor beta 4.2e-33 1.00
STS_HUMAN STS Steryl-sulfatase 1.045e-146 0.60
DHB1_HUMAN HSD17B1 Estradiol 17-beta-dehydrogenase 1 2.289e-76 0.57
SO1A1_RAT Slco1a1 Solute carrier organic anion transporter family member 1A1 1.266e-74 0.67
Q95MF8_PIG Sulfotransferase 6.262e-73 0.44
S22A3_RAT Slc22a3 Solute carrier family 22 member 3 2.139e-41 0.67
SHBG_HUMAN SHBG Sex hormone-binding globulin 6.829e-41 0.67
TBB2B_BOVIN TUBB2B Tubulin beta-2B chain 1.91e-36 0.51
AK1C3_HUMAN AKR1C3 Aldo-keto reductase family 1 member C3 3.759e-36 0.52
ERR2_HUMAN ESRRB Steroid hormone receptor ERR2 1.353e-35 0.67
CBG_HUMAN SERPINA6 Corticosteroid-binding globulin 7.459e-34 0.67
ADCYA_HUMAN ADCY10 Adenylate cyclase type 10 2.424e-30 0.49
GPER1_HUMAN GPER1 G-protein coupled estrogen receptor 1 1.375e-26 0.67
Q862F3_BOVIN Similar to alpha-tubulin isoform 1 2.974e-26 0.46
ST1E1_BOVIN SULT1E1 Sulfotransferase 1E1 5.379e-25 0.31
S22A8_RAT Slc22a8 Solute carrier family 22 member 8 6.482e-25 0.40
ESR1_MOUSE Esr1 Estrogen receptor 1.46e-20 0.67
ESR2_MOUSE Esr2 Estrogen receptor beta 1.46e-20 0.67
ADCY5_RAT Adcy5 Adenylate cyclase type 5 3.09e-19 0.37
ERR1_HUMAN ESRRA Steroid hormone receptor ERR1 1.76e-18 0.67
SO1B1_HUMAN SLCO1B1 Solute carrier organic anion transporter family member 1B1 3.625e-18 0.50
Q690N0_BOVIN PGR Progesterone receptor 7.295e-18 0.67
OPRM_BOVIN OPRM1 Mu-type opioid receptor 1.554e-15 0.29
MRP4_HUMAN ABCC4 Multidrug resistance-associated protein 4 2.653e-14 0.43
ESR1_RAT Esr1 Estrogen receptor 5.551e-14 0.67
S22A3_HUMAN SLC22A3 Solute carrier family 22 member 3 8.66e-14 0.67
CP19A_HUMAN CYP19A1 Aromatase 6.112e-13 0.57
CP24A_RAT Cyp24a1 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial 9.7e-12 0.29
S5A1_HUMAN SRD5A1 3-oxo-5-alpha-steroid 4-dehydrogenase 1 1.019e-09 0.41
S22A1_HUMAN SLC22A1 Solute carrier family 22 member 1 1.087e-09 0.67
C11B2_RAT Cyp11b2 Cytochrome P450 11B2, mitochondrial 1.207e-08 0.39
ANDR_RAT Ar Androgen receptor 2.432e-08 0.67
ESR2_RAT Esr2 Estrogen receptor beta 5.395e-08 0.67
GCR_HUMAN NR3C1 Glucocorticoid receptor 1.152e-07 0.43
CP1B1_HUMAN CYP1B1 Cytochrome P450 1B1 3.608e-07 0.67
MRP1_HUMAN ABCC1 Multidrug resistance-associated protein 1 1.253e-06 0.49
LOX15_RABIT ALOX15 Arachidonate 15-lipoxygenase 1.274e-06 0.67
PNMT_BOVIN PNMT Phenylethanolamine N-methyltransferase 1.621e-06 0.33
DRD2_BOVIN DRD2 D(2) dopamine receptor 3.199e-06 0.33

Entrectinib

ALK_HUMAN ALK ALK tyrosine kinase receptor 1.254e-34 1.00
INSR_HUMAN INSR Insulin receptor 9.737e-33 1.00
FLT3_HUMAN FLT3 Receptor-type tyrosine-protein kinase FLT3 7.136e-26 1.00
ROS1_HUMAN ROS1 Proto-oncogene tyrosine-protein kinase ROS 2.019e-22 1.00
KIT_HUMAN KIT Mast/stem cell growth factor receptor Kit 2.22e-16 1.00
AURKA_HUMAN AURKA Aurora kinase A 2.331e-15 1.00
RET_HUMAN RET Proto-oncogene tyrosine-protein kinase receptor Ret 3.109e-15 1.00
IGF1R_HUMAN IGF1R Insulin-like growth factor 1 receptor 6.772e-15 1.00
FER_HUMAN FER Tyrosine-protein kinase Fer 2.62e-14 1.00
DAPK3_HUMAN DAPK3 Death-associated protein kinase 3 3.63e-14 1.00
M4K5_HUMAN MAP4K5 Mitogen-activated protein kinase kinase kinase kinase 5 1.734e-11 1.00
HIPK2_HUMAN HIPK2 Homeodomain-interacting protein kinase 2 1.815e-11 1.00
RON_HUMAN MST1R Macrophage-stimulating protein receptor 2.365e-11 1.00
FRK_HUMAN FRK Tyrosine-protein kinase FRK 8.314e-11 1.00
CDK7_HUMAN CDK7 Cyclin-dependent kinase 7 2.141e-10 1.00
AURKB_HUMAN AURKB Aurora kinase B 4.701e-10 1.00
LTK_HUMAN LTK Leukocyte tyrosine kinase receptor 6.106e-10 1.00
KCC1D_HUMAN CAMK1D Calcium/calmodulin-dependent protein kinase type 1D 1.564e-09 1.00
CSF1R_HUMAN CSF1R Macrophage colony-stimulating factor 1 receptor 1.99e-09 1.00
FGFR1_HUMAN FGFR1 Fibroblast growth factor receptor 1 3.4e-09 1.00
CLK2_HUMAN CLK2 Dual specificity protein kinase CLK2 7.165e-09 1.00
PLK4_HUMAN PLK4 Serine/threonine-protein kinase PLK4 7.373e-09 1.00
NTRK3_HUMAN NTRK3 NT-3 growth factor receptor 1.115e-08 1.00
PKN2_HUMAN PKN2 Serine/threonine-protein kinase N2 1.135e-08 1.00
UFO_HUMAN AXL Tyrosine-protein kinase receptor UFO 1.548e-08 1.00
KPCG_HUMAN PRKCG Protein kinase C gamma type 1.626e-08 1.00
AAPK1_HUMAN PRKAA1 5'-AMP-activated protein kinase catalytic subunit alpha-1 6.17e-08 1.00
PTK6_HUMAN PTK6 Protein-tyrosine kinase 6 6.318e-08 1.00
SLK_HUMAN SLK STE20-like serine/threonine-protein kinase 1.79e-07 1.00
VGFR1_HUMAN FLT1 Vascular endothelial growth factor receptor 1 2.251e-07 1.00
M4K2_HUMAN MAP4K2 Mitogen-activated protein kinase kinase kinase kinase 2 3.374e-07 1.00
KSYK_HUMAN SYK Tyrosine-protein kinase SYK 3.706e-07 1.00
TAOK1_HUMAN TAOK1 Serine/threonine-protein kinase TAO1 6.857e-07 1.00
M4K4_HUMAN MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4 1.068e-06 1.00
GRK5_HUMAN GRK5 G protein-coupled receptor kinase 5 1.826e-06 1.00
ACK1_HUMAN TNK2 Activated CDC42 kinase 1 4.25e-06 1.00
STK3_HUMAN STK3 Serine/threonine-protein kinase 3 4.63e-06 1.00
LRRK2_HUMAN LRRK2 Leucine-rich repeat serine/threonine-protein kinase 2 7.314e-06 1.00
FGFR3_HUMAN FGFR3 Fibroblast growth factor receptor 3 7.413e-06 1.00
FYN_HUMAN FYN Tyrosine-protein kinase Fyn 1.325e-05 1.00
LYN_HUMAN LYN Tyrosine-protein kinase Lyn 2.388e-05 1.00
FAK1_HUMAN PTK2 Focal adhesion kinase 1 3.376e-05 1.00
BLK_HUMAN BLK Tyrosine-protein kinase Blk 3.535e-05 1.00
CLK4_HUMAN CLK4 Dual specificity protein kinase CLK4 9.093e-05 1.00
LCK_HUMAN LCK Tyrosine-protein kinase Lck 0.0001062 1.00
VGFR3_HUMAN FLT4 Vascular endothelial growth factor receptor 3 0.0001137 1.00
VGFR2_HUMAN KDR Vascular endothelial growth factor receptor 2 0.0001999 1.00
JAK3_HUMAN JAK3 Tyrosine-protein kinase JAK3 0.0003794 1.00
KS6A3_HUMAN RPS6KA3 Ribosomal protein S6 kinase alpha-3 0.000525 1.00
TBK1_HUMAN TBK1 Serine/threonine-protein kinase TBK1 0.001072 1.00
NTRK2_HUMAN NTRK2 BDNF/NT-3 growth factors receptor 0.001153 1.00
ABL1_HUMAN ABL1 Tyrosine-protein kinase ABL1 0.008736 1.00
KPCT_HUMAN PRKCQ Protein kinase C theta type 0.01175 1.00
JAK2_HUMAN JAK2 Tyrosine-protein kinase JAK2 0.02143 1.00
MET_HUMAN MET Hepatocyte growth factor receptor 0.03256 1.00
SRC_HUMAN SRC Proto-oncogene tyrosine-protein kinase Src 0.08585 1.00
NTRK1_HUMAN NTRK1 High affinity nerve growth factor receptor 0.08972 1.00
BTK_HUMAN BTK Tyrosine-protein kinase BTK 0.3251 1.00
JAK1_HUMAN JAK1 Tyrosine-protein kinase JAK1 0.676 1.00
BCL2_MOUSE Bcl2 Apoptosis regulator Bcl-2 6.152e-36 0.33
MK03_MOUSE Mapk3 Mitogen-activated protein kinase 3 4.317e-29 0.30
BCL2_HUMAN BCL2 Apoptosis regulator Bcl-2 8.68e-27 0.33
PARP1_HUMAN PARP1 Poly [ADP-ribose] polymerase 1 4.274e-23 0.36
Q4DCQ3_TRYCC Superoxide dismutase 5.225e-23 0.28
PRKDC_MOUSE Prkdc DNA-dependent protein kinase catalytic subunit 5.518e-23 0.28
MK01_MOUSE Mapk1 Mitogen-activated protein kinase 1 1.026e-22 0.34
B2CL1_MOUSE Bcl2l1 Bcl-2-like protein 1 3.948e-22 0.32
S27A1_HUMAN SLC27A1 Long-chain fatty acid transport protein 1 2.039e-21 0.32
KPCD1_HUMAN PRKD1 Serine/threonine-protein kinase D1 1.858e-19 0.32
5HT1F_HUMAN HTR1F 5-hydroxytryptamine receptor 1F 2.098e-19 0.38
PARP6_HUMAN PARP6 Protein mono-ADP-ribosyltransferase PARP6 9.052e-19 0.30
TTK_HUMAN TTK Dual specificity protein kinase TTK 1.219e-18 0.39
S27A1_MOUSE Slc27a1 Long-chain fatty acid transport protein 1 6.629e-18 0.32
STAT6_HUMAN STAT6 Signal transducer and activator of transcription 6 4.714e-17 0.33
SSR1_HUMAN SSTR1 Somatostatin receptor type 1 1.11e-16 0.30
MTOR_RAT Mtor Serine/threonine-protein kinase mTOR 6.661e-16 0.29
PAR16_HUMAN PARP16 Protein mono-ADP-ribosyltransferase PARP16 1.11e-15 0.30
CCNC_HUMAN CCNC Cyclin-C 1.221e-15 0.33
5HT1B_GORGO HTR1B 5-hydroxytryptamine receptor 1B 3.22e-15 0.29
WDR5_HUMAN WDR5 WD repeat-containing protein 5 6.106e-15 0.32
5HT1D_RAT Htr1d 5-hydroxytryptamine receptor 1D 1.528e-13 0.30
CDK8_HUMAN CDK8 Cyclin-dependent kinase 8 1.808e-12 0.33
INCE_HUMAN INCENP Inner centromere protein 4.1e-12 0.39
CDK2_HUMAN CDK2 Cyclin-dependent kinase 2 5.45e-12 0.43
5HT1B_HUMAN HTR1B 5-hydroxytryptamine receptor 1B 7.72e-11 0.38
CDK1_HUMAN CDK1 Cyclin-dependent kinase 1 1.358e-10 0.43
CCNA1_HUMAN CCNA1 Cyclin-A1 1.843e-10 0.33
GSK3B_HUMAN GSK3B Glycogen synthase kinase-3 beta 2.554e-10 0.35
TSSK1_HUMAN TSSK1B Testis-specific serine/threonine-protein kinase 1 3.435e-10 0.31
KISSR_RAT Kiss1r KiSS-1 receptor 4.612e-10 0.29
DCLK1_HUMAN DCLK1 Serine/threonine-protein kinase DCLK1 8.048e-10 0.31
PARP4_HUMAN PARP4 Protein mono-ADP-ribosyltransferase PARP4 1.582e-09 0.30
TLR9_HUMAN TLR9 Toll-like receptor 9 1.676e-09 0.30
SSR3_HUMAN SSTR3 Somatostatin receptor type 3 1.747e-09 0.30
KPCB_HUMAN PRKCB Protein kinase C beta type 2.398e-09 0.31
TF7L2_HUMAN TCF7L2 Transcription factor 7-like 2 2.459e-09 0.32
ST17A_HUMAN STK17A Serine/threonine-protein kinase 17A 2.48e-09 0.34
5HT1D_HUMAN HTR1D 5-hydroxytryptamine receptor 1D 2.63e-09 0.38
CDK4_HUMAN CDK4 Cyclin-dependent kinase 4 3.294e-09 0.43
DRD4_RAT Drd4 D(4) dopamine receptor 6.7e-09 0.31
REV1_HUMAN REV1 DNA repair protein REV1 8.999e-09 0.33
MK01_HUMAN MAPK1 Mitogen-activated protein kinase 1 9.346e-09 0.36
CTNB1_HUMAN CTNNB1 Catenin beta-1 1.303e-08 0.32
CSN5_HUMAN COPS5 COP9 signalosome complex subunit 5 1.751e-08 0.28
FGFR2_HUMAN FGFR2 Fibroblast growth factor receptor 2 1.912e-08 0.40
VGFR2_MOUSE Kdr Vascular endothelial growth factor receptor 2 3.318e-08 0.30
Q8VBU5_MOUSE Pde4b Phosphodiesterase 5.511e-08 0.35
CDC7_HUMAN CDC7 Cell division cycle 7-related protein kinase 1.216e-07 0.34
MERTK_HUMAN MERTK Tyrosine-protein kinase Mer 1.241e-07 0.34
PRKX_HUMAN PRKX cAMP-dependent protein kinase catalytic subunit PRKX 1.404e-07 0.34
MK09_HUMAN MAPK9 Mitogen-activated protein kinase 9 2.397e-07 0.34
MELK_HUMAN MELK Maternal embryonic leucine zipper kinase 2.809e-07 0.34
PAK4_HUMAN PAK4 Serine/threonine-protein kinase PAK 4 3.48e-07 0.34
Q76353_9HIV1 Integrase 4.538e-07 0.34
AURKC_HUMAN AURKC Aurora kinase C 7.033e-07 0.33
DYRK4_HUMAN DYRK4 Dual specificity tyrosine-phosphorylation-regulated kinase 4 9.465e-07 0.31
Q7ZJM1_9HIV1 pol Integrase 9.602e-07 0.33
PHKG2_HUMAN PHKG2 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 1.267e-06 0.31
SSR2_RAT Sstr2 Somatostatin receptor type 2 1.389e-06 0.29
5HT2A_HUMAN HTR2A 5-hydroxytryptamine receptor 2A 2.462e-06 0.33
KCC2B_HUMAN CAMK2B Calcium/calmodulin-dependent protein kinase type II subunit beta 3.241e-06 0.31
FES_HUMAN FES Tyrosine-protein kinase Fes/Fps 3.503e-06 0.31
PASK_HUMAN PASK PAS domain-containing serine/threonine-protein kinase 4.51e-06 0.30
KCC2G_HUMAN CAMK2G Calcium/calmodulin-dependent protein kinase type II subunit gamma 5.267e-06 0.31
SSR4_HUMAN SSTR4 Somatostatin receptor type 4 6.841e-06 0.29
SSR1_RAT Sstr1 Somatostatin receptor type 1 7.254e-06 0.29
KISSR_HUMAN KISS1R KiSS-1 receptor 9.476e-06 0.31

Tezacaftor

CFTR_HUMAN CFTR Cystic fibrosis transmembrane conductance regulator 2.833e-30 1.00
STIM1_RAT Stim1 Stromal interaction molecule 1 2.742e-14 0.29
CRCM1_RAT Orai1 Calcium release-activated calcium channel protein 1 3.745e-09 0.29

Nirogacestat

APH1A_HUMAN APH1A Gamma-secretase subunit APH-1A 1.295e-27 1.00
APH1B_HUMAN APH1B Gamma-secretase subunit APH-1B 1.295e-27 1.00
NICA_HUMAN NCSTN Nicastrin 1.295e-27 1.00
PEN2_HUMAN PSENEN Gamma-secretase subunit PEN-2 1.328e-27 1.00
PSN2_HUMAN PSEN2 Presenilin-2 1.431e-27 1.00
PSN1_HUMAN PSEN1 Presenilin-1 1.428e-26 1.00

Abemaciclib

CDK6_HUMAN CDK6 Cyclin-dependent kinase 6 4.038e-27 1.00
CCND3_HUMAN CCND3 G1/S-specific cyclin-D3 6.878e-22 1.00
CCNH_HUMAN CCNH Cyclin-H 3.251e-20 1.00
CCND1_HUMAN CCND1 G1/S-specific cyclin-D1 2.004e-19 1.00
MAT1_HUMAN MNAT1 CDK-activating kinase assembly factor MAT1 2.176e-19 1.00
CDK4_HUMAN CDK4 Cyclin-dependent kinase 4 1.776e-15 1.00
CCNB1_HUMAN CCNB1 G2/mitotic-specific cyclin-B1 5.103e-10 1.00
CCNA2_HUMAN CCNA2 Cyclin-A2 9.372e-10 1.00
CDK7_HUMAN CDK7 Cyclin-dependent kinase 7 2.865e-09 1.00
CDK2_HUMAN CDK2 Cyclin-dependent kinase 2 5.89e-09 1.00
CDK1_HUMAN CDK1 Cyclin-dependent kinase 1 4.736e-08 1.00
CCNT1_HUMAN CCNT1 Cyclin-T1 2.077e-07 1.00
CDK9_HUMAN CDK9 Cyclin-dependent kinase 9 0.0002651 1.00
CCNE1_HUMAN CCNE1 G1/S-specific cyclin-E1 0.004044 1.00
CD5R1_HUMAN CDK5R1 Cyclin-dependent kinase 5 activator 1 0.07123 1.00
CDK5_HUMAN CDK5 Cyclin-dependent-like kinase 5 0.3149 1.00
UFO_HUMAN AXL Tyrosine-protein kinase receptor UFO 1.216e-09 0.39

Lemborexant

OX2R_HUMAN HCRTR2 Orexin receptor type 2 1.343e-24 1.00
OX1R_HUMAN HCRTR1 Orexin receptor type 1 4.83e-22 1.00
KCNH2_HUMAN KCNH2 Potassium voltage-gated channel subfamily H member 2 0.08934 1.00
ABL1_HUMAN ABL1 Tyrosine-protein kinase ABL1 1.307e-33 0.38
GRM5_RAT Grm5 Metabotropic glutamate receptor 5 3.692e-27 0.39
PD2R2_RAT Ptgdr2 Prostaglandin D2 receptor 2 5.518e-23 0.28
BACE2_MOUSE Bace2 Beta-secretase 2 1.11e-16 0.30
LUCI_AQULA Luciferin 4-monooxygenase 2.22e-16 0.30
OX2R_RAT Hcrtr2 Orexin receptor type 2 1.665e-15 0.30
OX1R_RAT Hcrtr1 Orexin receptor type 1 1.59e-13 0.31
FA10_RAT F10 Coagulation factor X 7.484e-12 0.29
NTRK1_HUMAN NTRK1 High affinity nerve growth factor receptor 6.64e-11 0.33
BACE1_MOUSE Bace1 Beta-secretase 1 3.768e-08 0.30
BACE2_HUMAN BACE2 Beta-secretase 2 1.755e-07 0.33
IL6_HUMAN IL6 Interleukin-6 1.881e-07 0.29
SCNAA_RAT Scn10a Sodium channel protein type 10 subunit alpha 2.042e-07 0.34
SCN5A_HUMAN SCN5A Sodium channel protein type 5 subunit alpha 6.666e-07 0.30
ADA17_HUMAN ADAM17 Disintegrin and metalloproteinase domain-containing protein 17 7.246e-07 0.36
Q56D28_CAVPO CRTH2 Chemoattractant receptor-homologous molecule expressed on Th2 cells 1.122e-06 0.28
SCN9A_HUMAN SCN9A Sodium channel protein type 9 subunit alpha 1.289e-06 0.31
GRM5_HUMAN GRM5 Metabotropic glutamate receptor 5 1.778e-06 0.37
PD2R2_MOUSE Ptgdr2 Prostaglandin D2 receptor 2 1.995e-06 0.28
NPY5R_HUMAN NPY5R Neuropeptide Y receptor type 5 3.469e-06 0.35
V1AR_RAT Avpr1a Vasopressin V1a receptor 6.434e-06 0.32
GBRA5_HUMAN GABRA5 Gamma-aminobutyric acid receptor subunit alpha-5 8.916e-06 0.32
Q03732_HBV HBcAg Capsid protein 9.676e-06 0.30

Rilmenidine

NISCH_HUMAN NISCH Nischarin 4.981e-23 1.00
NISCH_RAT Nisch Nischarin 1.621e-14 1.00
ADA2B_HUMAN ADRA2B Alpha-2B adrenergic receptor 1.694e-11 1.00
ADA2C_HUMAN ADRA2C Alpha-2C adrenergic receptor 7.551e-09 1.00
ADA2A_HUMAN ADRA2A Alpha-2A adrenergic receptor 3.581e-08 1.00
ADA1A_HUMAN ADRA1A Alpha-1A adrenergic receptor 0.09668 1.00
CP2D6_HUMAN CYP2D6 Cytochrome P450 2D6 0.7197 1.00
CP3A4_HUMAN CYP3A4 Cytochrome P450 3A4 0.9947 1.00

Glasdegib

SMO_MOUSE Smo Smoothened homolog 7.309e-22 1.00
HYES_MOUSE Ephx2 Bifunctional epoxide hydrolase 2 3.638e-76 0.36
DEF_MYCTU def Peptide deformylase 5.694e-56 0.39
HYES_HUMAN EPHX2 Bifunctional epoxide hydrolase 2 6.299e-36 0.42
GRM5_MOUSE Grm5 Metabotropic glutamate receptor 5 1.626e-31 0.31
FAS_HUMAN FASN Fatty acid synthase 1.69e-30 0.39
HYEP_MOUSE Ephx1 Epoxide hydrolase 1 6.678e-30 0.45
ENL_HUMAN MLLT1 Protein ENL 2.705e-29 0.36
HPSE_HUMAN HPSE Heparanase 2.204e-27 0.41
HYEP_HUMAN EPHX1 Epoxide hydrolase 1 1.092e-26 0.45
FTSZ_MYCTU ftsZ Cell division protein FtsZ 1.736e-24 0.30
H9YX08_MACMU CCR6 C-C chemokine receptor type 6 2.063e-23 0.29
STK39_RAT Stk39 STE20/SPS1-related proline-alanine-rich protein kinase 2.625e-23 0.34
NR2E3_HUMAN NR2E3 Photoreceptor-specific nuclear receptor 2.032e-20 0.32
SHH_MOUSE Shh Sonic hedgehog protein 1.216e-17 0.41
KCNN3_RAT Kcnn3 Small conductance calcium-activated potassium channel protein 3 2.675e-17 0.33
CCR6_HUMAN CCR6 C-C chemokine receptor type 6 1.11e-16 0.32
PCP_HUMAN PRCP Lysosomal Pro-X carboxypeptidase 1.221e-15 0.31
POLG_HCVCO Genome polyprotein 2.109e-15 0.30
BPTF_HUMAN BPTF Nucleosome-remodeling factor subunit BPTF 2.665e-15 0.29
PPIA_RAT Ppia Peptidyl-prolyl cis-trans isomerase A 2.68e-13 0.30
DPP4_RAT Dpp4 Dipeptidyl peptidase 4 8.346e-13 0.40
Q5L478_9HEPC NS5A Nonstructural protein 5A 7.425e-12 0.30
Q9FBC5_STREE fabK Enoyl-ACP reductase II 4.136e-11 0.35
GYRB_MYCSM gyrB DNA gyrase subunit B 9.805e-11 0.35
MCHR1_MOUSE Mchr1 Melanin-concentrating hormone receptor 1 6.67e-10 0.31
CETP_HUMAN CETP Cholesteryl ester transfer protein 6.122e-09 0.31
HYES_RAT Ephx2 Bifunctional epoxide hydrolase 2 7.317e-09 0.32
DCNL1_HUMAN DCUN1D1 DCN1-like protein 1 9.384e-09 0.29
CCR3_HUMAN CCR3 C-C chemokine receptor type 3 2.39e-08 0.35
ROCK2_HUMAN ROCK2 Rho-associated protein kinase 2 2.858e-08 0.35
PDE10_HUMAN PDE10A cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 7.09e-08 0.33
PARP1_HUMAN PARP1 Poly [ADP-ribose] polymerase 1 1.157e-07 0.37
KLF5_HUMAN KLF5 Krueppel-like factor 5 1.299e-07 0.33
TRPV1_HUMAN TRPV1 Transient receptor potential cation channel subfamily V member 1 1.941e-07 0.33
PARP2_HUMAN PARP2 Poly [ADP-ribose] polymerase 2 3.148e-07 0.34
GPR6_HUMAN GPR6 G-protein coupled receptor 6 4.132e-07 0.30
TPP2_RAT Tpp2 Tripeptidyl-peptidase 2 5.692e-07 0.37
NPY5R_RAT Npy5r Neuropeptide Y receptor type 5 6.082e-07 0.34
LDLR_HUMAN LDLR Low-density lipoprotein receptor 8.345e-07 0.31
5HT2B_HUMAN HTR2B 5-hydroxytryptamine receptor 2B 9.32e-07 0.36
GYRA_STAAU gyrA DNA gyrase subunit A 9.85e-07 0.34
DRD2_HUMAN DRD2 D(2) dopamine receptor 1.053e-06 0.45
KS6A2_HUMAN RPS6KA2 Ribosomal protein S6 kinase alpha-2 1.093e-06 0.33
CDKA1_HUMAN CDK2AP1 Cyclin-dependent kinase 2-associated protein 1 1.676e-06 0.30
ITK_HUMAN ITK Tyrosine-protein kinase ITK/TSK 1.684e-06 0.30
KC1G2_HUMAN CSNK1G2 Casein kinase I isoform gamma-2 2.474e-06 0.30
TAAR1_RAT Taar1 Trace amine-associated receptor 1 3.662e-06 0.38
Q0GMK6_RABIT CDK4 Cyclin-dependent kinase 4 6.522e-06 0.30

Edaravone

RECA_MYCTU recA Protein RecA 7.174e-20 1.00
DNAB_MYCTU dnaB Replicative DNA helicase 1.573e-19 1.00
Q93EK7_NEIME lgtC LgtC 6.516e-57 0.36
MYH10_HUMAN MYH10 Myosin-10 3.917e-38 0.30
MYH14_MOUSE Myh14 Myosin-14 3.917e-38 0.30
MYH7_PIG MYH7 Myosin-7 3.917e-38 0.30
MYH9_HUMAN MYH9 Myosin-9 3.917e-38 0.30
Q789A4_CHICK MYH10 Nonmuscle myosin heavy chain 3.917e-38 0.30
MYH4_RABIT MYH4 Myosin-4 1.535e-24 0.30
MYS2_DICDI mhcA Myosin-2 heavy chain 1.535e-24 0.30
FCGR1_HUMAN FCGR1A High affinity immunoglobulin gamma Fc receptor I 2.158e-24 0.30
LOXL4_HUMAN LOXL4 Lysyl oxidase homolog 4 2.239e-24 0.47
LYOX_HUMAN LOX Protein-lysine 6-oxidase 1.305e-20 0.47
LOXL3_HUMAN LOXL3 Lysyl oxidase homolog 3 2.795e-20 0.47
GCN5_YEAST GCN5 Histone acetyltransferase GCN5 1.656e-17 0.33
CATG_HUMAN CTSG Cathepsin G 1.088e-14 0.36
A0A060INS8_CAPHI CTSH Cathepsin H 1.954e-14 0.34
RT109_YEAST RTT109 Histone acetyltransferase RTT109 2.682e-13 0.33
CTRA_BOVIN Chymotrypsinogen A 4.291e-13 0.36
5NTD_HUMAN NT5E 5'-nucleotidase 3.911e-12 0.61
H9B8T9_CAPHI CTSB Cathepsin B 7.485e-11 0.34
KCNJ6_HUMAN KCNJ6 G protein-activated inward rectifier potassium channel 2 8.85e-11 0.30
PPOC_ORYSJ PPOX1 Protoporphyrinogen oxidase, chloroplastic 1.157e-09 0.32
R1AB_SARS rep Replicase polyprotein 1ab 2.915e-09 0.33
BAX_HUMAN BAX Apoptosis regulator BAX 4.316e-09 0.28
AA2BR_MOUSE Adora2b Adenosine receptor A2b 4.438e-09 0.28
KCNJ3_HUMAN KCNJ3 G protein-activated inward rectifier potassium channel 1 1.26e-08 0.30
RGS8_HUMAN RGS8 Regulator of G-protein signaling 8 1.607e-08 0.28
EP300_HUMAN EP300 Histone acetyltransferase p300 1.771e-08 0.33
LOXL2_HUMAN LOXL2 Lysyl oxidase homolog 2 8.704e-08 0.47
KCNJ5_HUMAN KCNJ5 G protein-activated inward rectifier potassium channel 4 8.872e-08 0.30
DOPO_HUMAN DBH Dopamine beta-hydroxylase 1.324e-07 0.28
MPI_HUMAN MPI Mannose-6-phosphate isomerase 1.537e-07 0.33
A4_HUMAN APP Amyloid-beta precursor protein 2.753e-07 0.81
REV_HV1H2 rev Protein Rev 2.786e-07 0.28
PHOP1_HUMAN PHOSPHO1 Phosphoethanolamine/phosphocholine phosphatase 9.717e-07 0.29
BGAL_ECOLX lacZ Beta-galactosidase 2.186e-06 0.37

Fostamatinib

KSYK_HUMAN SYK Tyrosine-protein kinase SYK 5.259e-18 1.00
VGFR2_HUMAN KDR Vascular endothelial growth factor receptor 2 0.007368 1.00
FAK1_HUMAN PTK2 Focal adhesion kinase 1 7.402e-40 0.62
CDKL1_HUMAN CDKL1 Cyclin-dependent kinase-like 1 2.443e-27 0.62
ALK_HUMAN ALK ALK tyrosine kinase receptor 1.282e-24 0.62
NEK3_HUMAN NEK3 Serine/threonine-protein kinase Nek3 4.386e-22 0.62
KIT_MOUSE Kit Mast/stem cell growth factor receptor Kit 2.686e-20 0.62
NEK11_HUMAN NEK11 Serine/threonine-protein kinase Nek11 2.686e-20 0.62
ZAP70_HUMAN ZAP70 Tyrosine-protein kinase ZAP-70 1.159e-19 0.62
STK38_HUMAN STK38 Serine/threonine-protein kinase 38 7.617e-19 0.62
INSR_HUMAN INSR Insulin receptor 3.647e-18 0.62
KAPCB_HUMAN PRKACB cAMP-dependent protein kinase catalytic subunit beta 1.232e-17 0.62
NEK9_HUMAN NEK9 Serine/threonine-protein kinase Nek9 1.11e-16 0.62
TLK2_HUMAN TLK2 Serine/threonine-protein kinase tousled-like 2 1.11e-16 0.62
MARK4_HUMAN MARK4 MAP/microtubule affinity-regulating kinase 4 6.661e-16 0.62
COQ8A_HUMAN COQ8A Atypical kinase COQ8A, mitochondrial 9.992e-16 0.62
OXSR1_HUMAN OXSR1 Serine/threonine-protein kinase OSR1 9.992e-16 0.62
ST32A_HUMAN STK32A Serine/threonine-protein kinase 32A 5.884e-15 0.62
ULK1_HUMAN ULK1 Serine/threonine-protein kinase ULK1 1.51e-14 0.62
COQ8B_HUMAN COQ8B Atypical kinase COQ8B, mitochondrial 2.776e-14 0.62
NEK5_HUMAN NEK5 Serine/threonine-protein kinase Nek5 2.776e-14 0.62
NEK7_HUMAN NEK7 Serine/threonine-protein kinase Nek7 2.776e-14 0.62
PI51C_HUMAN PIP5K1C Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma 2.776e-14 0.62
SBK3_HUMAN SBK3 Uncharacterized serine/threonine-protein kinase SBK3 2.776e-14 0.62
STK11_HUMAN STK11 Serine/threonine-protein kinase STK11 2.776e-14 0.62
TLK1_HUMAN TLK1 Serine/threonine-protein kinase tousled-like 1 2.776e-14 0.62
ULK2_HUMAN ULK2 Serine/threonine-protein kinase ULK2 3.231e-14 0.62
TSSK1_HUMAN TSSK1B Testis-specific serine/threonine-protein kinase 1 8.793e-14 0.62
LRRK2_HUMAN LRRK2 Leucine-rich repeat serine/threonine-protein kinase 2 9.825e-14 0.62
NIM1_HUMAN NIM1K Serine/threonine-protein kinase NIM1 1.109e-13 0.62
WEE2_HUMAN WEE2 Wee1-like protein kinase 2 1.109e-13 0.62
SIK2_HUMAN SIK2 Serine/threonine-protein kinase SIK2 1.502e-13 0.62
M3K10_HUMAN MAP3K10 Mitogen-activated protein kinase kinase kinase 10 2.308e-13 0.62
AURKA_MOUSE Aurka Aurora kinase A 3.922e-13 0.29
IGF1R_HUMAN IGF1R Insulin-like growth factor 1 receptor 7.012e-13 0.62
BMX_HUMAN BMX Cytoplasmic tyrosine-protein kinase BMX 1.088e-12 0.62
KCC1G_HUMAN CAMK1G Calcium/calmodulin-dependent protein kinase type 1G 1.177e-12 0.62
SBK1_HUMAN SBK1 Serine/threonine-protein kinase SBK1 1.177e-12 0.62
NEK6_HUMAN NEK6 Serine/threonine-protein kinase Nek6 3.255e-12 0.62
PAK6_HUMAN PAK6 Serine/threonine-protein kinase PAK 6 3.255e-12 0.62
RIPK4_HUMAN RIPK4 Receptor-interacting serine/threonine-protein kinase 4 3.255e-12 0.62
PLK1_HUMAN PLK1 Serine/threonine-protein kinase PLK1 6.537e-12 0.62
NDUA4_HUMAN NDUFA4 Cytochrome c oxidase subunit NDUFA4 7.334e-12 0.29
INSRR_HUMAN INSRR Insulin receptor-related protein 8.236e-12 0.62
M3K4_HUMAN MAP3K4 Mitogen-activated protein kinase kinase kinase 4 8.236e-12 0.62
MYLK4_HUMAN MYLK4 Myosin light chain kinase family member 4 8.236e-12 0.62
TEC_HUMAN TEC Tyrosine-protein kinase Tec 9.462e-12 0.62
NEK4_HUMAN NEK4 Serine/threonine-protein kinase Nek4 1.812e-11 0.62
LATS2_HUMAN LATS2 Serine/threonine-protein kinase LATS2 1.93e-11 0.62
MP2K6_HUMAN MAP2K6 Dual specificity mitogen-activated protein kinase kinase 6 1.93e-11 0.62
PI42B_HUMAN PIP4K2B Phosphatidylinositol 5-phosphate 4-kinase type-2 beta 1.93e-11 0.62
TESK1_HUMAN TESK1 Dual specificity testis-specific protein kinase 1 1.93e-11 0.62
CDK17_HUMAN CDK17 Cyclin-dependent kinase 17 4.228e-11 0.62
AURKA_HUMAN AURKA Aurora kinase A 6.501e-11 0.62
MARK3_HUMAN MARK3 MAP/microtubule affinity-regulating kinase 3 6.626e-11 0.62
ANKK1_HUMAN ANKK1 Ankyrin repeat and protein kinase domain-containing protein 1 8.732e-11 0.62
MARK1_HUMAN MARK1 Serine/threonine-protein kinase MARK1 8.732e-11 0.62
PAK5_HUMAN PAK5 Serine/threonine-protein kinase PAK 5 8.732e-11 0.62
PI51A_HUMAN PIP5K1A Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha 8.732e-11 0.62
STK35_HUMAN STK35 Serine/threonine-protein kinase 35 8.732e-11 0.62
CDKL2_HUMAN CDKL2 Cyclin-dependent kinase-like 2 1.712e-10 0.62
MUSK_HUMAN MUSK Muscle, skeletal receptor tyrosine-protein kinase 1.712e-10 0.62
STK25_HUMAN STK25 Serine/threonine-protein kinase 25 1.712e-10 0.62
SRMS_HUMAN SRMS Tyrosine-protein kinase Srms 1.907e-10 0.62
RIOK1_HUMAN RIOK1 Serine/threonine-protein kinase RIO1 3.204e-10 0.62
RIOK2_HUMAN RIOK2 Serine/threonine-protein kinase RIO2 3.204e-10 0.62
RIOK3_HUMAN RIOK3 Serine/threonine-protein kinase RIO3 3.204e-10 0.62
STK36_HUMAN STK36 Serine/threonine-protein kinase 36 3.204e-10 0.62
ULK3_HUMAN ULK3 Serine/threonine-protein kinase ULK3 3.204e-10 0.62
SRPK3_HUMAN SRPK3 SRSF protein kinase 3 5.754e-10 0.62
LGUL_HUMAN GLO1 Lactoylglutathione lyase 6.886e-10 0.33
GRK1_HUMAN GRK1 Rhodopsin kinase GRK1 9.956e-10 0.62
GRK4_HUMAN GRK4 G protein-coupled receptor kinase 4 9.956e-10 0.62
PAK1_HUMAN PAK1 Serine/threonine-protein kinase PAK 1 1.539e-09 0.62
DCLK3_HUMAN DCLK3 Serine/threonine-protein kinase DCLK3 1.666e-09 0.62
IRAK3_HUMAN IRAK3 Interleukin-1 receptor-associated kinase 3 1.666e-09 0.62
MK15_HUMAN MAPK15 Mitogen-activated protein kinase 15 1.666e-09 0.62
PLK3_HUMAN PLK3 Serine/threonine-protein kinase PLK3 1.878e-09 0.62
STAT6_HUMAN STAT6 Signal transducer and activator of transcription 6 2.076e-09 0.30
KCC1A_HUMAN CAMK1 Calcium/calmodulin-dependent protein kinase type 1 2.453e-09 0.62
EPHA7_HUMAN EPHA7 Ephrin type-A receptor 7 2.705e-09 0.62
MP2K3_HUMAN MAP2K3 Dual specificity mitogen-activated protein kinase kinase 3 2.705e-09 0.62
TNK1_HUMAN TNK1 Non-receptor tyrosine-protein kinase TNK1 2.705e-09 0.62
DYRK4_HUMAN DYRK4 Dual specificity tyrosine-phosphorylation-regulated kinase 4 2.76e-09 0.62
KCC2A_HUMAN CAMK2A Calcium/calmodulin-dependent protein kinase type II subunit alpha 2.764e-09 0.62
TSSK2_HUMAN TSSK2 Testis-specific serine/threonine-protein kinase 2 2.797e-09 0.39
EPHA5_HUMAN EPHA5 Ephrin type-A receptor 5 4.271e-09 0.62
GRK7_HUMAN GRK7 Rhodopsin kinase GRK7 4.271e-09 0.62
M3K3_HUMAN MAP3K3 Mitogen-activated protein kinase kinase kinase 3 4.271e-09 0.62
MP2K4_HUMAN MAP2K4 Dual specificity mitogen-activated protein kinase kinase 4 4.271e-09 0.62
PAK3_HUMAN PAK3 Serine/threonine-protein kinase PAK 3 4.271e-09 0.62
ERBB4_HUMAN ERBB4 Receptor tyrosine-protein kinase erbB-4 4.999e-09 0.62
CDK9_HUMAN CDK9 Cyclin-dependent kinase 9 6.976e-09 0.36
MK12_HUMAN MAPK12 Mitogen-activated protein kinase 12 7.493e-09 0.62
BMP2K_HUMAN BMP2K BMP-2-inducible protein kinase 9.903e-09 0.62
DAPK2_HUMAN DAPK2 Death-associated protein kinase 2 9.903e-09 0.62
EPHA8_HUMAN EPHA8 Ephrin type-A receptor 8 9.903e-09 0.62
SIK1_HUMAN SIK1 Serine/threonine-protein kinase SIK1 9.903e-09 0.62
TAOK2_HUMAN TAOK2 Serine/threonine-protein kinase TAO2 9.903e-09 0.62
STK16_HUMAN STK16 Serine/threonine-protein kinase 16 1.46e-08 0.62
DCLK1_HUMAN DCLK1 Serine/threonine-protein kinase DCLK1 1.495e-08 0.39
PHKG2_HUMAN PHKG2 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 1.875e-08 0.62
DAPK1_HUMAN DAPK1 Death-associated protein kinase 1 2.11e-08 0.62
EPHA4_HUMAN EPHA4 Ephrin type-A receptor 4 2.11e-08 0.62
M4K3_HUMAN MAP4K3 Mitogen-activated protein kinase kinase kinase kinase 3 2.11e-08 0.62
NUAK2_HUMAN NUAK2 NUAK family SNF1-like kinase 2 2.11e-08 0.62
CTRO_HUMAN CIT Citron Rho-interacting kinase 2.997e-08 0.62
HIPK3_HUMAN HIPK3 Homeodomain-interacting protein kinase 3 2.997e-08 0.62
M3K2_HUMAN MAP3K2 Mitogen-activated protein kinase kinase kinase 2 2.997e-08 0.62
PAK2_HUMAN PAK2 Serine/threonine-protein kinase PAK 2 2.997e-08 0.62
LTK_HUMAN LTK Leukocyte tyrosine kinase receptor 3.525e-08 0.62
M4K1_HUMAN MAP4K1 Mitogen-activated protein kinase kinase kinase kinase 1 4.188e-08 0.62
FES_HUMAN FES Tyrosine-protein kinase Fes/Fps 4.215e-08 0.62
BLK_HUMAN BLK Tyrosine-protein kinase Blk 4.414e-08 0.62
MP2K2_HUMAN MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 5.022e-08 0.62
FRK_HUMAN FRK Tyrosine-protein kinase FRK 5.201e-08 0.62
EPHA1_HUMAN EPHA1 Ephrin type-A receptor 1 5.762e-08 0.62
EPHB1_HUMAN EPHB1 Ephrin type-B receptor 1 5.762e-08 0.62
ACV1B_HUMAN ACVR1B Activin receptor type-1B 7.817e-08 0.62
EPHA6_HUMAN EPHA6 Ephrin type-A receptor 6 7.817e-08 0.62
PKN1_HUMAN PKN1 Serine/threonine-protein kinase N1 7.817e-08 0.62
ROS1_HUMAN ROS1 Proto-oncogene tyrosine-protein kinase ROS 7.828e-08 0.62
NTRK2_HUMAN NTRK2 BDNF/NT-3 growth factors receptor 8.518e-08 0.62
SRPK1_HUMAN SRPK1 SRSF protein kinase 1 1.029e-07 0.62
BMR1B_HUMAN BMPR1B Bone morphogenetic protein receptor type-1B 1.047e-07 0.62
EPHB2_HUMAN EPHB2 Ephrin type-B receptor 2 1.047e-07 0.62
M3K9_HUMAN MAP3K9 Mitogen-activated protein kinase kinase kinase 9 1.792e-07 0.62
HIPK1_HUMAN HIPK1 Homeodomain-interacting protein kinase 1 1.81e-07 0.62
TIE1_HUMAN TIE1 Tyrosine-protein kinase receptor Tie-1 1.81e-07 0.62
FER_HUMAN FER Tyrosine-protein kinase Fer 1.823e-07 0.62
SLK_HUMAN SLK STE20-like serine/threonine-protein kinase 1.852e-07 0.62
HIPK4_HUMAN HIPK4 Homeodomain-interacting protein kinase 4 2.733e-07 0.62
PLK4_HUMAN PLK4 Serine/threonine-protein kinase PLK4 2.958e-07 0.62
NUAK1_HUMAN NUAK1 NUAK family SNF1-like kinase 1 2.999e-07 0.62
TAOK1_HUMAN TAOK1 Serine/threonine-protein kinase TAO1 3.359e-07 0.62
AAK1_HUMAN AAK1 AP2-associated protein kinase 1 3.805e-07 0.62
EPHB6_HUMAN EPHB6 Ephrin type-B receptor 6 3.805e-07 0.62
DDR1_HUMAN DDR1 Epithelial discoidin domain-containing receptor 1 5.799e-07 0.62
MATK_HUMAN MATK Megakaryocyte-associated tyrosine-protein kinase 8.518e-07 0.36
MP2K5_HUMAN MAP2K5 Dual specificity mitogen-activated protein kinase kinase 5 1.106e-06 0.62
CDK2_HUMAN CDK2 Cyclin-dependent kinase 2 1.178e-06 0.62
MARK2_HUMAN MARK2 Serine/threonine-protein kinase MARK2 1.196e-06 0.62
BRSK1_HUMAN BRSK1 Serine/threonine-protein kinase BRSK1 1.231e-06 0.39
FYN_HUMAN FYN Tyrosine-protein kinase Fyn 1.257e-06 0.62
KS6A4_HUMAN RPS6KA4 Ribosomal protein S6 kinase alpha-4 1.34e-06 0.62
FAK2_HUMAN PTK2B Protein-tyrosine kinase 2-beta 1.517e-06 0.62
STK10_HUMAN STK10 Serine/threonine-protein kinase 10 1.614e-06 0.62
AAPK1_HUMAN PRKAA1 5'-AMP-activated protein kinase catalytic subunit alpha-1 1.674e-06 0.62
KKCC2_HUMAN CAMKK2 Calcium/calmodulin-dependent protein kinase kinase 2 1.766e-06 0.36
E2AK4_HUMAN EIF2AK4 eIF-2-alpha kinase GCN2 1.932e-06 0.62
EPHA3_HUMAN EPHA3 Ephrin type-A receptor 3 1.932e-06 0.62
ABL2_HUMAN ABL2 Tyrosine-protein kinase ABL2 2.299e-06 0.62
LYN_HUMAN LYN Tyrosine-protein kinase Lyn 2.534e-06 0.62
NEK2_HUMAN NEK2 Serine/threonine-protein kinase Nek2 2.62e-06 0.62
KCC2G_HUMAN CAMK2G Calcium/calmodulin-dependent protein kinase type II subunit gamma 2.96e-06 0.62
PAK4_HUMAN PAK4 Serine/threonine-protein kinase PAK 4 3.044e-06 0.62
HIPK2_HUMAN HIPK2 Homeodomain-interacting protein kinase 2 3.371e-06 0.62
KPCD2_HUMAN PRKD2 Serine/threonine-protein kinase D2 3.461e-06 0.62
STK33_HUMAN STK33 Serine/threonine-protein kinase 33 5.095e-06 0.62
M3K19_HUMAN MAP3K19 Mitogen-activated protein kinase kinase kinase 19 5.894e-06 0.62
ST17A_HUMAN STK17A Serine/threonine-protein kinase 17A 6.521e-06 0.62
M3K11_HUMAN MAP3K11 Mitogen-activated protein kinase kinase kinase 11 6.791e-06 0.62
TXK_HUMAN TXK Tyrosine-protein kinase TXK 6.791e-06 0.62
LCK_HUMAN LCK Tyrosine-protein kinase Lck 6.832e-06 0.62
IRAK1_HUMAN IRAK1 Interleukin-1 receptor-associated kinase 1 6.958e-06 0.62
KPCG_HUMAN PRKCG Protein kinase C gamma type 7.682e-06 0.62
UFO_HUMAN AXL Tyrosine-protein kinase receptor UFO 7.899e-06 0.62

Esketamine

ACHA_TETCF CHRNA1 Acetylcholine receptor subunit alpha 1.377e-17 1.00
NMDE1_HUMAN GRIN2A Glutamate receptor ionotropic, NMDA 2A 4.652e-10 1.00
CAC1C_HUMAN CACNA1C Voltage-dependent L-type calcium channel subunit alpha-1C 5.715e-06 1.00
NMDZ1_HUMAN GRIN1 Glutamate receptor ionotropic, NMDA 1 1.778e-05 1.00
NMDE2_HUMAN GRIN2B Glutamate receptor ionotropic, NMDA 2B 0.001649 1.00
FTO_HUMAN FTO Alpha-ketoglutarate-dependent dioxygenase FTO 4.431e-13 0.32
HPPD_PIG HPD 4-hydroxyphenylpyruvate dioxygenase 1.732e-08 0.31

Diacerein

GLD1_CAEEL gld-1 Female germline-specific tumor suppressor gld-1 2.22e-17 1.00
NAAA_HUMAN NAAA N-acylethanolamine-hydrolyzing acid amidase 1.164e-06 1.00
CASP3_HUMAN CASP3 Caspase-3 0.01328 1.00
POLI_MOUSE Poli DNA polymerase iota 4.868e-48 0.32
CFAD_RAT Cfd Complement factor D 1.083e-43 0.35
DPOLM_HUMAN POLM DNA-directed DNA/RNA polymerase mu 7.545e-40 0.32
TDT_BOVIN DNTT DNA nucleotidylexotransferase 7.545e-40 0.32
HIF1N_HUMAN HIF1AN Hypoxia-inducible factor 1-alpha inhibitor 9.362e-36 0.28
POLH_HUMAN POLH DNA polymerase eta 8.028e-31 0.32
CYAA_BACAN cya Calmodulin-sensitive adenylate cyclase 1.383e-30 0.34
G6PT1_HUMAN SLC37A4 Glucose-6-phosphate exchanger SLC37A4 1.188e-28 0.38
AL1A7_RAT Aldh1a7 Aldehyde dehydrogenase, cytosolic 1 1.574e-27 0.34
GSHR_PLAF7 GR3 Glutathione reductase 2.652e-26 0.30
FTO_HUMAN FTO Alpha-ketoglutarate-dependent dioxygenase FTO 1.134e-25 0.37
MCR_RAT Nr3c2 Mineralocorticoid receptor 2.965e-25 0.34
POLK_HUMAN POLK DNA polymerase kappa 8.089e-24 0.32
Q44079_AERHY cphA2 Beta-lactamase 4.989e-23 0.28
GABT_RAT Abat 4-aminobutyrate aminotransferase, mitochondrial 1.983e-22 0.35
REV_HV1H2 rev Protein Rev 1.041e-20 0.29
KC1A_PIG CSNK1A1 Casein kinase I isoform alpha 1.2e-20 0.32
TLR1_MOUSE Tlr1 Toll-like receptor 1 5.834e-20 0.40
TLR2_MOUSE Tlr2 Toll-like receptor 2 5.834e-20 0.40
PGAM1_HUMAN PGAM1 Phosphoglycerate mutase 1 1.523e-18 0.29
P2Y14_MOUSE P2ry14 P2Y purinoceptor 14 6.293e-18 0.31
O96394_LEIAM Arginase 1.11e-16 0.30
Q9BEG3_BOVIN 5-lipoxygenase 1.11e-16 0.50
KDM3A_HUMAN KDM3A Lysine-specific demethylase 3A 2.331e-15 0.30
LOX12_MOUSE Alox12 Arachidonate 12-lipoxygenase, 12S-type 7.883e-15 0.28
P89582_9HIV2 pol Integrase 2.753e-14 0.31
APEX1_HUMAN APEX1 DNA-(apurinic or apyrimidinic site) lyase 2.422e-12 0.31
LPXC_AQUAE lpxC UDP-3-O-acyl-N-acetylglucosamine deacetylase 1.92e-11 0.31
KDM4E_HUMAN KDM4E Lysine-specific demethylase 4E 8.123e-10 0.30
DPOLL_HUMAN POLL DNA polymerase lambda 6.704e-09 0.32
PE2R1_HUMAN PTGER1 Prostaglandin E2 receptor EP1 subtype 7.647e-09 0.35
KDM2A_HUMAN KDM2A Lysine-specific demethylase 2A 1.275e-08 0.30
GSHR_HUMAN GSR Glutathione reductase, mitochondrial 1.111e-07 0.30
Q6TUJ4_PSEAI blaIMP-1 Metallo beta-lactamase 1.199e-07 0.28
ACPS_BACSU acpS Holo-[acyl-carrier-protein] synthase 1.84e-07 0.31
AK1C3_HUMAN AKR1C3 Aldo-keto reductase family 1 member C3 1.996e-07 0.31
PTPRC_HUMAN PTPRC Receptor-type tyrosine-protein phosphatase C 6.854e-07 0.38
B2LUN4_PIG GSK3-beta Glycogen synthase kinase 3 beta 9.911e-07 0.32
DPOLB_RAT Polb DNA polymerase beta 1.263e-06 0.32
NSD2_HUMAN NSD2 Histone-lysine N-methyltransferase NSD2 1.692e-06 0.32
PGH1_BOVIN PTGS1 Prostaglandin G/H synthase 1 2.081e-06 0.42
G5EF15_CAEEL pos-1 Cytoplasmic zinc-finger protein 6.491e-06 0.40
KDM5C_HUMAN KDM5C Lysine-specific demethylase 5C 7.447e-06 0.30

Lorlatinib

ALK_HUMAN ALK ALK tyrosine kinase receptor 5.345e-11 1.00
NTRK2_HUMAN NTRK2 BDNF/NT-3 growth factors receptor 2.93e-09 1.00
FES_HUMAN FES Tyrosine-protein kinase Fes/Fps 7.034e-07 1.00
FER_HUMAN FER Tyrosine-protein kinase Fer 3.343e-05 1.00
LTK_HUMAN LTK Leukocyte tyrosine kinase receptor 0.0001565 1.00
FRK_HUMAN FRK Tyrosine-protein kinase FRK 0.0005951 1.00
ROS1_HUMAN ROS1 Proto-oncogene tyrosine-protein kinase ROS 0.0007265 1.00
NTRK3_HUMAN NTRK3 NT-3 growth factor receptor 0.001649 1.00
FAK2_HUMAN PTK2B Protein-tyrosine kinase 2-beta 0.01077 1.00
ACK1_HUMAN TNK2 Activated CDC42 kinase 1 0.03267 1.00
FAK1_HUMAN PTK2 Focal adhesion kinase 1 0.4508 1.00
NTRK1_HUMAN NTRK1 High affinity nerve growth factor receptor 0.9164 1.00

Abametapir

CCR8_HUMAN CCR8 C-C chemokine receptor type 8 1.286e-10 1.00
CCR5_HUMAN CCR5 C-C chemokine receptor type 5 0.1449 1.00
P4HA1_HUMAN P4HA1 Prolyl 4-hydroxylase subunit alpha-1 3.191e-42 0.38
LUCI_AQULA Luciferin 4-monooxygenase 3.138e-12 0.35
CSN5_HUMAN COPS5 COP9 signalosome complex subunit 5 1.689e-10 0.35
P2RX3_RAT P2rx3 P2X purinoceptor 3 1.634e-07 0.30
CXCR4_RAT Cxcr4 C-X-C chemokine receptor type 4 1.721e-07 0.38
C11B1_RAT Cyp11b1 Cytochrome P450 11B1, mitochondrial 6.965e-06 0.32

Tideglusib

GSK3B_HUMAN GSK3B Glycogen synthase kinase-3 beta 1.002e-05 1.00
RGS4_HUMAN RGS4 Regulator of G-protein signaling 4 6.828e-148 0.65
RGS8_HUMAN RGS8 Regulator of G-protein signaling 8 1.715e-119 0.65
RGS16_HUMAN RGS16 Regulator of G-protein signaling 16 2.703e-52 0.42
RGS19_HUMAN RGS19 Regulator of G-protein signaling 19 2.703e-52 0.42
FABP7_HUMAN FABP7 Fatty acid-binding protein, brain 6.19e-52 0.28
HPRK_BACSU hprK HPr kinase/phosphorylase 4.048e-41 0.33
DYR_BOVIN DHFR Dihydrofolate reductase 7.066e-35 0.35
TLR7_HUMAN TLR7 Toll-like receptor 7 2.003e-26 0.33
RAD1_HUMAN RAD1 Cell cycle checkpoint protein RAD1 3.931e-23 0.37
FABP4_HUMAN FABP4 Fatty acid-binding protein, adipocyte 2.984e-22 0.37
Q9FD53_STREE mvaD Diphosphomevalonate decarboxylase 8.067e-21 0.29
CLH1_HUMAN CLTC Clathrin heavy chain 1 4.11e-19 0.30
Q38C41_TRYB2 Phosphotransferase 1.11e-16 0.33
P2RX4_HUMAN P2RX4 P2X purinoceptor 4 6.661e-16 0.45
MDHM_HUMAN MDH2 Malate dehydrogenase, mitochondrial 3.331e-15 0.30
PA2GE_MOUSE Pla2g2e Group IIE secretory phospholipase A2 3.331e-15 0.30
PA21B_MOUSE Pla2g1b Phospholipase A2 8.227e-14 0.30
PA2GE_HUMAN PLA2G2E Group IIE secretory phospholipase A2 8.227e-14 0.30
PA2GF_MOUSE Pla2g2f Group IIF secretory phospholipase A2 2.039e-13 0.29
PA2GA_MOUSE Pla2g2a Phospholipase A2, membrane associated 3.136e-13 0.30
PA2GD_HUMAN PLA2G2D Group IID secretory phospholipase A2 3.136e-13 0.30
CFTR_HUMAN CFTR Cystic fibrosis transmembrane conductance regulator 4.97e-12 0.35
PA2GD_MOUSE Pla2g2d Group IID secretory phospholipase A2 5.427e-12 0.29
AL3A1_HUMAN ALDH3A1 Aldehyde dehydrogenase, dimeric NADP-preferring 6.984e-12 0.36
AL1A1_HUMAN ALDH1A1 Retinal dehydrogenase 1 2.444e-11 0.36
CAC1I_HUMAN CACNA1I Voltage-dependent T-type calcium channel subunit alpha-1I 4.497e-11 0.31
CH10_HUMAN HSPE1 10 kDa heat shock protein, mitochondrial 1.904e-10 0.35
CH60_HUMAN HSPD1 60 kDa heat shock protein, mitochondrial 1.904e-10 0.35
P2RX4_MOUSE P2rx4 P2X purinoceptor 4 4.884e-10 0.29
PHOP1_HUMAN PHOSPHO1 Phosphoethanolamine/phosphocholine phosphatase 5.026e-10 0.30
RMLC_MYCTO rmlC dTDP-4-dehydrorhamnose 3,5-epimerase 8.811e-10 0.28
PA2GF_HUMAN PLA2G2F Group IIF secretory phospholipase A2 2.304e-09 0.29
PA2GX_MOUSE Pla2g10 Group 10 secretory phospholipase A2 8.719e-09 0.29
P2RX4_RAT P2rx4 P2X purinoceptor 4 9.079e-09 0.29
IL8_HUMAN CXCL8 Interleukin-8 9.522e-09 0.29
ERCC5_HUMAN ERCC5 DNA repair protein complementing XP-G cells 4.97e-08 0.40
PPAP_HUMAN ACP3 Prostatic acid phosphatase 8.839e-08 0.29
AA3R_HUMAN ADORA3 Adenosine receptor A3 1.216e-07 0.37
Q5J463_SALCH tem-1 Beta-lactamase 1.421e-07 0.30
PA2G5_MOUSE Pla2g5 Calcium-dependent phospholipase A2 1.664e-07 0.29
CAC1H_HUMAN CACNA1H Voltage-dependent T-type calcium channel subunit alpha-1H 1.802e-07 0.31
KCNN2_RAT Kcnn2 Small conductance calcium-activated potassium channel protein 2 2.041e-07 0.29
RAD51_HUMAN RAD51 DNA repair protein RAD51 homolog 1 2.126e-07 0.37
FABPH_HUMAN FABP3 Fatty acid-binding protein, heart 2.307e-07 0.37
FABP5_HUMAN FABP5 Fatty acid-binding protein 5 3.591e-07 0.28
CASP7_HUMAN CASP7 Caspase-7 4.228e-07 0.33
FEN1_HUMAN FEN1 Flap endonuclease 1 5.558e-07 0.40
EPHA4_MOUSE Epha4 Ephrin type-A receptor 4 6.105e-07 0.30
PNPH_RAT Pnp Purine nucleoside phosphorylase 7.828e-07 0.33
PA2GX_HUMAN PLA2G10 Group 10 secretory phospholipase A2 3.083e-06 0.30
P2RX1_HUMAN P2RX1 P2X purinoceptor 1 3.559e-06 0.29
PKR1_HUMAN PROKR1 Prokineticin receptor 1 5.058e-06 0.34
C3TDZ2_ECOLX fabH 3-oxoacyl-[acyl-carrier-protein] synthase 3 9.582e-06 0.30

Nefopam

CP2D6_HUMAN CYP2D6 Cytochrome P450 2D6 1.26e-05 1.00
SC6A2_MOUSE Slc6a2 Sodium-dependent noradrenaline transporter 1.858e-51 0.37
SC6A3_MOUSE Slc6a3 Sodium-dependent dopamine transporter 4.948e-41 0.37
VACHT_HUMAN SLC18A3 Vesicular acetylcholine transporter 8.769e-27 0.34
Q9WTR4_RAT Slc6a2 Transporter 1.199e-25 0.43
DRD1_RAT Drd1 D(1A) dopamine receptor 1.572e-25 0.42
VACHT_RAT Slc18a3 Vesicular acetylcholine transporter 3.603e-25 0.34
5HT7R_MOUSE Htr7 5-hydroxytryptamine receptor 7 2.158e-24 0.30
ADA1A_MOUSE Adra1a Alpha-1A adrenergic receptor 6.741e-19 0.30
ADA1D_MOUSE Adra1d Alpha-1D adrenergic receptor 6.741e-19 0.30
DRD5_HUMAN DRD5 D(1B) dopamine receptor 2.405e-18 0.36
DRD1_HUMAN DRD1 D(1A) dopamine receptor 5.433e-18 0.36
5HT1B_GORGO HTR1B 5-hydroxytryptamine receptor 1B 1.11e-16 0.32
SGMR1_RAT Sigmar1 Sigma non-opioid intracellular receptor 1 1.11e-16 0.43
ADA1B_MOUSE Adra1b Alpha-1B adrenergic receptor 8.882e-16 0.30
DRD3_MOUSE Drd3 D(3) dopamine receptor 8.882e-16 0.30
SC6A3_HUMAN SLC6A3 Sodium-dependent dopamine transporter 7.438e-15 0.53
Q9IP65_HCMV US28 G protein-coupled receptor 7.883e-15 0.28
SC6A3_RAT Slc6a3 Sodium-dependent dopamine transporter 1.454e-14 0.43
SC6A2_HUMAN SLC6A2 Sodium-dependent noradrenaline transporter 3.486e-14 0.53
SL9A3_HUMAN SLC9A3 Sodium/hydrogen exchanger 3 3.63e-14 0.30
SGMR1_HUMAN SIGMAR1 Sigma non-opioid intracellular receptor 1 3.919e-14 0.36
5HT1D_MOUSE Htr1d 5-hydroxytryptamine receptor 1D 2.757e-12 0.30
ACHA6_RAT Chrna6 Neuronal acetylcholine receptor subunit alpha-6 1.199e-11 0.33
SC6A4_HUMAN SLC6A4 Sodium-dependent serotonin transporter 1.554e-11 0.53
SC6A4_RAT Slc6a4 Sodium-dependent serotonin transporter 3.118e-11 0.43
DRD4_MOUSE Drd4 D(4) dopamine receptor 3.391e-11 0.30
DRD1_MOUSE Drd1 D(1A) dopamine receptor 5.398e-11 0.31
DRD2_RAT Drd2 D(2) dopamine receptor 5.834e-11 0.42
US28_HCMVA US28 G-protein coupled receptor homolog US28 1.647e-10 0.28
VACHT_TETCF Vesicular acetylcholine transporter 2.092e-10 0.34
5HT2B_MOUSE Htr2b 5-hydroxytryptamine receptor 2B 3.159e-10 0.30
ADA1B_MESAU ADRA1B Alpha-1B adrenergic receptor 5.817e-10 0.30
ACH10_RAT Chrna10 Neuronal acetylcholine receptor subunit alpha-10 1.125e-09 0.30
SGMR2_RAT Tmem97 Sigma intracellular receptor 2 4.305e-09 0.33
5HT2C_MOUSE Htr2c 5-hydroxytryptamine receptor 2C 5.367e-09 0.30
DRD4_RAT Drd4 D(4) dopamine receptor 5.632e-09 0.32
ADA1A_BOVIN ADRA1A Alpha-1A adrenergic receptor 2.617e-08 0.30
DRD3_HUMAN DRD3 D(3) dopamine receptor 5.054e-08 0.36
ACHP_LYMST Acetylcholine-binding protein 5.172e-08 0.34
DRD2_HUMAN DRD2 D(2) dopamine receptor 7.011e-08 0.36
HRH1_HUMAN HRH1 Histamine H1 receptor 1.151e-07 0.34
ACM5_RAT Chrm5 Muscarinic acetylcholine receptor M5 3.409e-07 0.33
DRD3_RAT Drd3 D(3) dopamine receptor 3.462e-07 0.32
TYTR_TRYBB TPR Trypanothione reductase 3.503e-07 0.32
NMDE2_HUMAN GRIN2B Glutamate receptor ionotropic, NMDA 2B 3.769e-07 0.39
ACM3_RAT Chrm3 Muscarinic acetylcholine receptor M3 4.604e-07 0.35
5HT2A_MOUSE Htr2a 5-hydroxytryptamine receptor 2A 4.707e-07 0.30
5HT2A_RAT Htr2a 5-hydroxytryptamine receptor 2A 5.623e-07 0.34
DRD4_HUMAN DRD4 D(4) dopamine receptor 1.185e-06 0.36
5HT2C_RAT Htr2c 5-hydroxytryptamine receptor 2C 2.631e-06 0.33
5HT2A_HUMAN HTR2A 5-hydroxytryptamine receptor 2A 2.692e-06 0.35
ACM1_RAT Chrm1 Muscarinic acetylcholine receptor M1 4.154e-06 0.38
SGMR1_CAVPO SIGMAR1 Sigma non-opioid intracellular receptor 1 8.586e-06 0.39

Citicoline

P2RY6_HUMAN P2RY6 P2Y purinoceptor 6 6.338e-286 0.56
P2RY2_HUMAN P2RY2 P2Y purinoceptor 2 2.97e-282 0.65
P2RY4_HUMAN P2RY4 P2Y purinoceptor 4 1.018e-211 0.56
P2Y14_HUMAN P2RY14 P2Y purinoceptor 14 3.412e-198 0.54
IF4E_MOUSE Eif4e Eukaryotic translation initiation factor 4E 1.042e-114 0.44
IF4E_RABIT EIF4E Eukaryotic translation initiation factor 4E 5.048e-111 0.44
DNPH1_HUMAN DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 3.172e-107 0.34
DNPH1_RAT Dnph1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 1.861e-105 0.34
SIAT1_HUMAN ST6GAL1 Beta-galactoside alpha-2,6-sialyltransferase 1 7.328e-98 0.57
P2RY1_RAT P2ry1 P2Y purinoceptor 1 6.91e-95 0.46
PUR6_CHICK AIRC Multifunctional protein ADE2 8.993e-81 0.41
P2RY4_RAT P2ry4 P2Y purinoceptor 4 1.097e-80 0.48
PARG_BOVIN PARG Poly(ADP-ribose) glycohydrolase 2.025e-72 0.38
P2Y11_HUMAN P2RY11 P2Y purinoceptor 11 2.963e-72 0.42
KAD2_RAT Ak2 Adenylate kinase 2, mitochondrial 5.458e-71 0.43
P2RY1_MELGA P2RY1 P2Y purinoceptor 1 1.072e-69 0.46
B4GT1_HUMAN B4GALT1 Beta-1,4-galactosyltransferase 1 1.525e-69 0.40
FUT6_HUMAN FUT6 Alpha-(1,3)-fucosyltransferase 6 5.61e-69 0.34
RNAS1_BOVIN RNASE1 Ribonuclease pancreatic 1.372e-66 0.49
KAD3_RAT Ak3 GTP:AMP phosphotransferase AK3, mitochondrial 4.419e-65 0.43
IMDH1_HUMAN IMPDH1 Inosine-5'-monophosphate dehydrogenase 1 2.261e-64 0.37
IMDH2_MOUSE Impdh2 Inosine-5'-monophosphate dehydrogenase 2 2.102e-62 0.37
RASK_HUMAN KRAS GTPase KRas 6.919e-62 0.40
KTHY_HUMAN DTYMK Thymidylate kinase 2.701e-61 0.36
PYRF_METTH pyrF Orotidine 5'-phosphate decarboxylase 8.338e-61 0.36
P2RY2_RAT P2ry2 P2Y purinoceptor 2 5.715e-60 0.48
POLG_POL1M Genome polyprotein 2.496e-59 0.47
ASNS_HUMAN ASNS Asparagine synthetase [glutamine-hydrolyzing] 2.189e-58 0.33
ENTE_ECOLI entE Enterobactin synthase component E 3.13e-58 0.37
DHE3_BOVIN GLUD1 Glutamate dehydrogenase 1, mitochondrial 3.181e-57 0.37
RN5A_MOUSE Rnasel 2-5A-dependent ribonuclease 7.485e-56 0.36
P2RX1_HUMAN P2RX1 P2X purinoceptor 1 1.991e-53 0.46
MPRI_HUMAN IGF2R Cation-independent mannose-6-phosphate receptor 2.799e-53 0.30
P2RX5_RAT P2rx5 P2X purinoceptor 5 2.848e-53 0.46
P2RX6_RAT P2rx6 P2X purinoceptor 6 2.848e-53 0.46
AMPD1_RABIT AMPD1 AMP deaminase 1 3.095e-53 0.36
HSP7C_BOVIN HSPA8 Heat shock cognate 71 kDa protein 7.775e-53 0.42
WALK_STAAU walK Sensor protein kinase WalK 7.775e-53 0.42
RNAS1_HUMAN RNASE1 Ribonuclease pancreatic 1.243e-52 0.33
RNAS2_HUMAN RNASE2 Non-secretory ribonuclease 1.243e-52 0.33
V5TFZ2_9FLAV Nonstructural protein 5 6.464e-52 0.44
PYRF_YEAST URA3 Orotidine 5'-phosphate decarboxylase 1.176e-51 0.38
DPOG1_HUMAN POLG DNA polymerase subunit gamma-1 1.291e-51 0.47
MACD1_HUMAN MACROD1 ADP-ribose glycohydrolase MACROD1 1.67e-51 0.41
MACD2_HUMAN MACROD2 ADP-ribose glycohydrolase MACROD2 1.67e-51 0.41
PANE_ECOLI panE 2-dehydropantoate 2-reductase 4.657e-51 0.32
METK2_RAT Mat2a S-adenosylmethionine synthase isoform type-2 1.251e-49 0.40
ISPE_ECOLI ispE 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 6.888e-48 0.38
GGTA1_BOVIN GGTA1 N-acetyllactosaminide alpha-1,3-galactosyltransferase 5.52e-47 0.37
Q8KHJ3_NEIME lgtC Alpha 1,4 galactosyltransferase 5.52e-47 0.37
UMPS_HUMAN UMPS Uridine 5'-monophosphate synthase 6.583e-47 0.32
ENTP1_BOVIN ENTPD1 Ectonucleoside triphosphate diphosphohydrolase 1 1.237e-46 0.37
RN5A_HUMAN RNASEL 2-5A-dependent ribonuclease 2.321e-45 0.36
KITH_RAT Tk1 Thymidine kinase, cytosolic 4.753e-45 0.41
BIRA_ECOLI birA Bifunctional ligase/repressor BirA 1.389e-44 0.35
Q8T6J6_PLAFA ompdc Orotidine 5'-monophosphate decarboxylase 1.17e-43 0.35
ENPP1_RAT Enpp1 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 1.895e-43 0.36
GPR17_HUMAN GPR17 Uracil nucleotide/cysteinyl leukotriene receptor 6.636e-42 0.49
AMPD_ARATH AMPD AMP deaminase 1.921e-39 0.31
P2RY6_RAT P2ry6 P2Y purinoceptor 6 2.728e-39 0.49
DPOLB_HUMAN POLB DNA polymerase beta 6.227e-37 0.47
C3SIU2_ECOLX metJ Met repressor 4.95e-33 0.30
IMDH2_HUMAN IMPDH2 Inosine-5'-monophosphate dehydrogenase 2 1.747e-32 0.37
SYRC_HUMAN RARS1 Arginine--tRNA ligase, cytoplasmic 1.92e-28 0.35
P2RX4_MOUSE P2rx4 P2X purinoceptor 4 2.084e-28 0.46
O39930_9HEPC NS5b RNA-directed RNA polymerase 1.041e-27 0.51
Q3ZDS5_9HEPC NS5B 2.667e-27 0.34
SIAT6_RAT St3gal3 CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase 1.315e-26 0.33
IF4E_HUMAN EIF4E Eukaryotic translation initiation factor 4E 1.374e-26 0.44
ADA_MOUSE Ada Adenosine deaminase 7.184e-26 0.32
P2RX4_RAT P2rx4 P2X purinoceptor 4 1.205e-24 0.46
CDK12_HUMAN CDK12 Cyclin-dependent kinase 12 1.418e-24 0.30
TYSY_BOVIN TYMS Thymidylate synthase 2.728e-24 0.30
BIP_HUMAN HSPA5 Endoplasmic reticulum chaperone BiP 6.802e-24 0.42
P2RX4_HUMAN P2RX4 P2X purinoceptor 4 1.273e-23 0.46
PARG_HUMAN PARG Poly(ADP-ribose) glycohydrolase 1.688e-23 0.38
BPL1_HUMAN HLCS Biotin--protein ligase 2.533e-23 0.35
CYAA_BACAN cya Calmodulin-sensitive adenylate cyclase 7.321e-23 0.51
ENPP1_HUMAN ENPP1 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 1.161e-22 0.46
SYQ_HUMAN QARS1 Glutamine--tRNA ligase 1.353e-21 0.34
P2RX1_RAT P2rx1 P2X purinoceptor 1 2.296e-21 0.43
MRAY_ECOLI mraY Phospho-N-acetylmuramoyl-pentapeptide-transferase 1.802e-19 0.31
B4GT1_BOVIN B4GALT1 Beta-1,4-galactosyltransferase 1 1.844e-19 0.37
P2RY2_MOUSE P2ry2 P2Y purinoceptor 2 3.967e-19 0.48
MRAY_BACSU mraY Phospho-N-acetylmuramoyl-pentapeptide-transferase 5.051e-19 0.30
METK1_RAT Mat1a S-adenosylmethionine synthase isoform type-1 3.886e-18 0.29
OGT1_HUMAN OGT UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 9.053e-18 0.49
PLCG1_HUMAN PLCG1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 2.445e-17 0.37
A0A0E7NXW5_STAAU birA Bifunctional ligase/repressor BirA 4.441e-16 0.35
MBTA_MYCTU mbtA Salicyl-AMP ligase / salicyl-S-ArCP synthetase 1.221e-15 0.30
DPOLA_HUMAN POLA1 DNA polymerase alpha catalytic subunit 4.774e-15 0.47
RAC1_HUMAN RAC1 Ras-related C3 botulinum toxin substrate 1 1.31e-14 0.44
P2RY1_HUMAN P2RY1 P2Y purinoceptor 1 2.442e-14 0.47
RAB7A_HUMAN RAB7A Ras-related protein Rab-7a 9.637e-14 0.44
CDC42_HUMAN CDC42 Cell division control protein 42 homolog 1.409e-13 0.44
TRPM2_HUMAN TRPM2 Transient receptor potential cation channel subfamily M member 2 3.773e-13 0.32
ADH1A_HUMAN ADH1A Alcohol dehydrogenase 1A 4.264e-13 0.36
DCPS_HUMAN DCPS m7GpppX diphosphatase 2.394e-11 0.44
CCNK_HUMAN CCNK Cyclin-K 2.943e-11 0.30
P2RX2_RAT P2rx2 P2X purinoceptor 2 3.015e-11 0.46
M9TGV3_MYCTX inhA Enoyl-[acyl-carrier-protein] reductase [NADH] 2.906e-10 0.34
ITPR1_RAT Itpr1 Inositol 1,4,5-trisphosphate receptor type 1 4.623e-10 0.29
PARG_RAT Parg Poly(ADP-ribose) glycohydrolase 1.901e-09 0.38
PUR9_HUMAN ATIC Bifunctional purine biosynthesis protein PURH 2.845e-09 0.34
ADK_HUMAN ADK Adenosine kinase 3.112e-09 0.40
PDCD4_HUMAN PDCD4 Programmed cell death protein 4 8.173e-09 0.29
P2Y12_RAT P2ry12 P2Y purinoceptor 12 1.668e-08 0.46
HS71A_HUMAN HSPA1A Heat shock 70 kDa protein 1A 3.262e-08 0.42
5NTD_RAT Nt5e 5'-nucleotidase 4.151e-08 0.42
CDD_MOUSE Cda Cytidine deaminase 9.17e-08 0.32
C3TDZ2_ECOLX fabH 3-oxoacyl-[acyl-carrier-protein] synthase 3 9.502e-08 0.42
HPRT_HUMAN HPRT1 Hypoxanthine-guanine phosphoribosyltransferase 9.806e-08 0.38
ENPL_CANLF HSP90B1 Endoplasmin 1.622e-07 0.42
5NTD_HUMAN NT5E 5'-nucleotidase 2.905e-07 0.35
CDD_HUMAN CDA Cytidine deaminase 6.505e-07 0.32
POLG_HCVBK Genome polyprotein 8.651e-07 0.33
HSP7C_HUMAN HSPA8 Heat shock cognate 71 kDa protein 1.007e-06 0.42
Q9WJQ2_9HIV1 reverse transcriptase Reverse transcriptase protein 1.753e-06 0.51
MAT1_HUMAN MNAT1 CDK-activating kinase assembly factor MAT1 2.252e-06 0.30
P2Y12_HUMAN P2RY12 P2Y purinoceptor 12 5.387e-06 0.47
TYSY_LACCA thyA Thymidylate synthase 5.67e-06 0.36

Elamipretide

OPRM_RAT Oprm1 Mu-type opioid receptor 7.15e-253 0.89
OPRD_RAT Oprd1 Delta-type opioid receptor 1.996e-249 0.89
MC5R_MOUSE Mc5r Melanocortin receptor 5 5.745e-226 0.58
OPRD_MOUSE Oprd1 Delta-type opioid receptor 1.378e-215 0.89
FURIN_HUMAN FURIN Furin 1.664e-208 0.55
MC4R_MOUSE Mc4r Melanocortin receptor 4 3.374e-193 0.58
OPRM_CAVPO OPRM1 Mu-type opioid receptor 1.809e-190 0.89
MC3R_MOUSE Mc3r Melanocortin receptor 3 3.328e-182 0.58
MSHR_MOUSE Mc1r Melanocyte-stimulating hormone receptor 2.27e-178 0.58
NTR2_HUMAN NTSR2 Neurotensin receptor type 2 7.755e-177 0.50
POLG_WNV Genome polyprotein 7.643e-157 0.55
PCSK6_HUMAN PCSK6 Proprotein convertase subtilisin/kexin type 6 2.517e-154 0.49
QRFPR_HUMAN QRFPR Pyroglutamylated RF-amide peptide receptor 6.338e-150 0.69
CCKAR_CAVPO CCKAR Cholecystokinin receptor type A 5.083e-147 0.44
CD36_RAT Cd36 Platelet glycoprotein 4 1.908e-146 0.45
PAR2_HUMAN F2RL1 Proteinase-activated receptor 2 2.87e-146 0.51
C3AR_HUMAN C3AR1 C3a anaphylatoxin chemotactic receptor 6.385e-145 0.54
CBX7_HUMAN CBX7 Chromobox protein homolog 7 1.165e-143 0.43
CAN2_HUMAN CAPN2 Calpain-2 catalytic subunit 1.453e-142 0.40
CDYL2_HUMAN CDYL2 Chromodomain Y-like protein 2 9.213e-136 0.36
GRIA1_RAT Gria1 Glutamate receptor 1 2.48e-135 0.44
NPFF1_HUMAN NPFFR1 Neuropeptide FF receptor 1 9.239e-135 0.62
NPFF2_HUMAN NPFFR2 Neuropeptide FF receptor 2 7.208e-127 0.62
TMPS6_HUMAN TMPRSS6 Transmembrane protease serine 6 1.75e-126 0.52
Q8I6Z5_PLAF7 Plasmepsin V 4.573e-126 0.46
MSHR_HUMAN MC1R Melanocyte-stimulating hormone receptor 2.455e-122 0.51
FCER2_HUMAN FCER2 Low affinity immunoglobulin epsilon Fc receptor 2.703e-117 0.37
Q8CGM4_CAVPO OPRM1 Mu-opioid receptor 8.18e-117 0.46
NTR1_HUMAN NTSR1 Neurotensin receptor type 1 1.583e-116 0.50
ERAP2_HUMAN ERAP2 Endoplasmic reticulum aminopeptidase 2 1.154e-114 0.46
MC3R_HUMAN MC3R Melanocortin receptor 3 1.9e-114 0.51
CATB_BOVIN CTSB Cathepsin B 6.991e-114 0.50
CBX4_HUMAN CBX4 E3 SUMO-protein ligase CBX4 2.67e-113 0.40
CBX8_HUMAN CBX8 Chromobox protein homolog 8 1.755e-109 0.37
AMD_RAT Pam Peptidylglycine alpha-amidating monooxygenase 1.242e-107 0.40
POLG_DEN26 Genome polyprotein 1.523e-107 0.48
MRGX1_MOUSE Mrgprx1 Mas-related G-protein coupled receptor member X1 4.642e-104 0.67
NPFF2_RAT Npffr2 Neuropeptide FF receptor 2 2.943e-102 0.47
KLK3_HUMAN KLK3 Prostate-specific antigen 5.596e-101 0.45
MCA2_TRYBB MCA2 Metacaspase 6.966e-100 0.41
LCAP_HUMAN LNPEP Leucyl-cystinyl aminopeptidase 1.885e-99 0.46
WDR5_HUMAN WDR5 WD repeat-containing protein 5 1.108e-97 0.46
GASR_HUMAN CCKBR Gastrin/cholecystokinin type B receptor 4.138e-95 0.50
NPY4R_HUMAN NPY4R Neuropeptide Y receptor type 4 1.347e-94 0.53
GASR_BOVIN CCKBR Gastrin/cholecystokinin type B receptor 5.959e-94 0.38
NK1R_RAT Tacr1 Substance-P receptor 1.37e-93 0.55
KISSR_HUMAN KISS1R KiSS-1 receptor 3.236e-93 0.52
NK2R_MESAU TACR2 Substance-K receptor 1.236e-92 0.42
CPNS1_PIG CAPNS1 Calpain small subunit 1 5.74e-91 0.38
PAR1_HUMAN F2R Proteinase-activated receptor 1 1.181e-88 0.57
NEC1_HUMAN PCSK1 Neuroendocrine convertase 1 9.005e-88 0.49
PCSK5_HUMAN PCSK5 Proprotein convertase subtilisin/kexin type 5 9.005e-88 0.49
NTR1_RAT Ntsr1 Neurotensin receptor type 1 2.47e-85 0.43
HGFA_HUMAN HGFAC Hepatocyte growth factor activator 4.802e-84 0.52
CAN1_HUMAN CAPN1 Calpain-1 catalytic subunit 1.913e-82 0.42
BXA1_CLOBH botA Botulinum neurotoxin type A 2.471e-82 0.51
ST14_MOUSE St14 Suppressor of tumorigenicity 14 protein homolog 2.337e-78 0.39
MC4R_HUMAN MC4R Melanocortin receptor 4 1.097e-77 0.52
MMP11_MOUSE Mmp11 Stromelysin-3 4.482e-77 0.34
CATB_RAT Ctsb Cathepsin B 1.847e-76 0.53
VM1B1_BOTAS Snake venom metalloproteinase BaP1 2.097e-75 0.55
NMDE1_RAT Grin2a Glutamate receptor ionotropic, NMDA 2A 3.701e-74 0.44
TM11D_HUMAN TMPRSS11D Transmembrane protease serine 11D 1.788e-73 0.44
TETX_CLOTE tetX Tetanus toxin 5.579e-73 0.31
CATJ_RAT Ctsj Cathepsin J 5.459e-72 0.50
SIR1_HUMAN SIRT1 NAD-dependent protein deacetylase sirtuin-1 1.137e-71 0.47
NK1R_CAVPO TACR1 Substance-P receptor 8.144e-71 0.48
PAPA1_CARPA Papain 1.326e-70 0.46
B3DH72_DANRE oprd1b Opioid receptor, delta 1b 6.818e-70 0.34
O57585_DANRE oprd1a Opioid receptor homologue 6.818e-70 0.34
SORT_HUMAN SORT1 Sortilin 7.739e-70 0.41
ERAP1_HUMAN ERAP1 Endoplasmic reticulum aminopeptidase 1 6.309e-69 0.46
NEC2_HUMAN PCSK2 Neuroendocrine convertase 2 6.312e-69 0.42
NEP_RABIT MME Neprilysin 1.727e-67 0.38
CATL1_HUMAN CTSL Cathepsin L1 1.979e-67 0.70
BLA1_STEMA Metallo-beta-lactamase L1 type 3 2.42e-67 0.44
OPRD_HUMAN OPRD1 Delta-type opioid receptor 3.322e-67 0.89
CATZ_RAT Ctsz Cathepsin Z 6.497e-66 0.50
KLKB1_HUMAN KLKB1 Plasma kallikrein 9.844e-66 0.43
NTR1_MOUSE Ntsr1 Neurotensin receptor type 1 2.602e-65 0.41
CAN2_BOVIN CAPN2 Calpain-2 catalytic subunit 1.1e-63 0.38
HEPS_HUMAN HPN Serine protease hepsin 1.27e-63 0.52
CATB_HUMAN CTSB Cathepsin B 2.175e-63 0.43
Q98UH1_DANRE oprm1 Mu opioid receptor-like OR2 2.91e-63 0.34
TRYB1_HUMAN TPSAB1 Tryptase alpha/beta-1 9.166e-63 0.42
NK3R_CAVPO TACR3 Neuromedin-K receptor 1.178e-62 0.42
PLMN_BOVIN PLG Plasminogen 1.924e-61 0.33
MBOA4_HUMAN MBOAT4 Ghrelin O-acyltransferase 3.065e-61 0.34
THER_BACTH npr Thermolysin 4.662e-60 0.34
CATC_RAT Ctsc Dipeptidyl peptidase 1 8.818e-60 0.50
TMPS2_HUMAN TMPRSS2 Transmembrane protease serine 2 8.916e-60 0.35
CHIA_SERMA chiA Chitinase A 9.066e-60 0.32
NK2R_RAT Tacr2 Substance-K receptor 1.065e-59 0.48
CATH_RAT Ctsh Pro-cathepsin H 3.404e-59 0.35
KLK1_HUMAN KLK1 Kallikrein-1 3.652e-59 0.43
FPR1_HUMAN FPR1 fMet-Leu-Phe receptor 5.806e-59 0.43
Q91H74_9FLAV Genome polyprotein 1.18e-58 0.64
ST14_HUMAN ST14 Suppressor of tumorigenicity 14 protein 1.53e-58 0.52
MMP8_RAT Mmp8 Neutrophil collagenase 3.266e-57 0.33
NEP_MOUSE Mme Neprilysin 1.407e-56 0.35
ELAS_PSEAE lasB Elastase 2.18e-56 0.52
OPRX_MOUSE Oprl1 Nociceptin receptor 2.946e-56 0.45
EPOR_HUMAN EPOR Erythropoietin receptor 1.631e-55 0.32
OPRK_RAT Oprk1 Kappa-type opioid receptor 2.101e-55 0.49
GRIA1_HUMAN GRIA1 Glutamate receptor 1 2.336e-55 0.45
OPRK_MOUSE Oprk1 Kappa-type opioid receptor 4.679e-53 0.49
MYLK_CHICK Mylk Myosin light chain kinase, smooth muscle 1.794e-51 0.41
NPY1R_HUMAN NPY1R Neuropeptide Y receptor type 1 1.514e-50 0.47
Q6MGC4_RAT Pfdn6 H2-K region expressed gene 2, rat orthologue 1.983e-50 0.41
OPRK_CAVPO OPRK1 Kappa-type opioid receptor 4.306e-50 0.89
PSB6_YEAST PRE7 Proteasome subunit beta type-6 6.101e-50 0.40
PCSK7_HUMAN PCSK7 Proprotein convertase subtilisin/kexin type 7 1.414e-49 0.42
AMPB_RAT Rnpep Aminopeptidase B 2.156e-49 0.46
CYSP_TRYCR Cruzipain 5.34e-49 0.38
O68720_YERPE yopH Targeted effector protein 2.032e-47 0.37
MMP11_HUMAN MMP11 Stromelysin-3 6.824e-47 0.32
Q9ERC0_RAT Npy2r Neuropeptide Y receptor Y2 9.545e-47 0.39
CFAB_HUMAN CFB Complement factor B 1.696e-46 0.38
SIR3_HUMAN SIRT3 NAD-dependent protein deacetylase sirtuin-3, mitochondrial 2.519e-46 0.47
AMPN_PIG ANPEP Aminopeptidase N 3.239e-46 0.40
MMP8_HUMAN MMP8 Neutrophil collagenase 8.278e-45 0.42
PSB5_HUMAN PSMB5 Proteasome subunit beta type-5 2.368e-44 0.41
POLG_HRV14 Genome polyprotein 1.756e-43 0.35
MMP3_HUMAN MMP3 Stromelysin-1 1.867e-43 0.45
Q4U254_9ENTO protease Protease 1.904e-43 0.41
Q95PM0_TRYBR rhodesain Cysteine protease 2.005e-43 0.37
PSB5_YEAST PRE2 Proteasome subunit beta type-5 9.28e-43 0.40
CBX5_HUMAN CBX5 Chromobox protein homolog 5 1.846e-42 0.34
TPP2_HUMAN TPP2 Tripeptidyl-peptidase 2 5.166e-42 0.33
PLMN_RAT Plg Plasminogen 6.135e-42 0.44
CTRB_BOVIN Chymotrypsinogen B 1.814e-41 0.31
NK2R_HUMAN TACR2 Substance-K receptor 2.886e-41 0.40
Q6IE76_BOVIN FDFT1 FDFT1 protein 4.673e-41 0.33
HLAA_HUMAN HLA-A HLA class I histocompatibility antigen, A alpha chain 9.878e-41 0.44
CBX2_HUMAN CBX2 Chromobox protein homolog 2 2.565e-40 0.32
CBX6_HUMAN CBX6 Chromobox protein homolog 6 2.565e-40 0.32
CDY1_HUMAN CDY1; CDY1B Testis-specific chromodomain protein Y 1 2.565e-40 0.32
CDYL_HUMAN CDYL Chromodomain Y-like protein 2.565e-40 0.32
ACE_HUMAN ACE Angiotensin-converting enzyme 2.864e-40 0.37
MMP12_HUMAN MMP12 Macrophage metalloelastase 4.74e-40 0.47
CAN1_PIG CAPN1 Calpain-1 catalytic subunit 8.02e-40 0.39
DPO1_THEAQ polA DNA polymerase I, thermostable 9.642e-39 0.37
SPLB_STAAU splB Serine protease SplB 9.65e-39 0.31
AMPB_MOUSE Rnpep Aminopeptidase B 1.007e-38 0.31
AMPL_BOVIN LAP3 Cytosol aminopeptidase 1.007e-38 0.31
NK3R_RAT Tacr3 Neuromedin-K receptor 1.036e-38 0.48
IL1RA_MOUSE Il1rn Interleukin-1 receptor antagonist protein 1.176e-38 0.31
OPRM_HUMAN OPRM1 Mu-type opioid receptor 1.257e-38 0.89
TGM2_HUMAN TGM2 Protein-glutamine gamma-glutamyltransferase 2 1.48e-38 0.38
Q99P97_RAT Histone deacetylase 6 3.17e-38 0.30
NK3R_HUMAN TACR3 Neuromedin-K receptor 3.317e-38 0.42
PADI6_HUMAN PADI6 Protein-arginine deiminase type-6 9.059e-38 0.32
THRB_HUMAN F2 Prothrombin 8.89e-37 0.44
Q9GSW0_PLAFA dhs Deoxyhypusine synthase 1.046e-36 0.29
PSB2_HUMAN PSMB2 Proteasome subunit beta type-2 1.865e-36 0.40
CANX_CHICK Calpain-1 catalytic subunit 2.333e-36 0.29
MMP1_HUMAN MMP1 Interstitial collagenase 3.577e-36 0.45
AMPN_RAT Anpep Aminopeptidase N 3.875e-36 0.29
NMT_CANAL NMT1 Glycylpeptide N-tetradecanoyltransferase 3.876e-36 0.43
S15A2_RAT Slc15a2 Solute carrier family 15 member 2 4.046e-36 0.33
MRGX1_RAT Mrgprx1 Mas-related G-protein coupled receptor member X1 5.644e-36 0.67
PADI1_HUMAN PADI1 Protein-arginine deiminase type-1 8.198e-36 0.39
TRYB1_RAT Tpsab1 Tryptase 1.377e-35 0.28
TRYT_CANLF Tryptase 1.377e-35 0.28
OPRM_MOUSE Oprm1 Mu-type opioid receptor 3.848e-35 0.53
IDE_HUMAN IDE Insulin-degrading enzyme 4.207e-35 0.54
CATL1_BOVIN CTSL Cathepsin L1 1.025e-34 0.37
NMUR1_HUMAN NMUR1 Neuromedin-U receptor 1 3.564e-34 0.42
S15A1_HUMAN SLC15A1 Solute carrier family 15 member 1 1.328e-33 0.35
SYYC_HUMAN YARS1 Tyrosine--tRNA ligase, cytoplasmic 2.201e-33 0.35
ANPRC_HUMAN NPR3 Atrial natriuretic peptide receptor 3 3.137e-33 0.33
DNPEP_HUMAN DNPEP Aspartyl aminopeptidase 3.685e-33 0.33
SIR2_HUMAN SIRT2 NAD-dependent protein deacetylase sirtuin-2 2.037e-32 0.47
CATL1_RAT Ctsl Cathepsin L1 2.411e-32 0.29
PSB1_HUMAN PSMB1 Proteasome subunit beta type-1 7.923e-32 0.41
NMUR2_HUMAN NMUR2 Neuromedin-U receptor 2 1.079e-31 0.42
NEP_HUMAN MME Neprilysin 1.39e-31 0.53
MMP10_HUMAN MMP10 Stromelysin-2 7.277e-31 0.42
FNTB_RAT Fntb Protein farnesyltransferase subunit beta 1.158e-29 0.44
FNTA_RAT Fnta Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha 1.973e-29 0.44
Q9NBD4_PLAFA Cysteine protease falcipain-2 2.705e-29 0.36
BKRB1_RAT Bdkrb1 B1 bradykinin receptor 3.397e-29 0.43
Q72874_9HIV1 pol Pol polyprotein 7.449e-29 0.41
MMP9_RAT Mmp9 Matrix metalloproteinase-9 1.811e-28 0.33
GASR_RAT Cckbr Gastrin/cholecystokinin type B receptor 2.076e-28 0.41
FA7_HUMAN F7 Coagulation factor VII 3.003e-28 0.54
CATK_HUMAN CTSK Cathepsin K 3.846e-28 0.51
PRSS8_HUMAN PRSS8 Prostasin 5.702e-28 0.38
ACE_MOUSE Ace Angiotensin-converting enzyme 1.112e-27 0.33
OPRK_HUMAN OPRK1 Kappa-type opioid receptor 1.437e-27 0.64
S15A2_HUMAN SLC15A2 Solute carrier family 15 member 2 2.164e-27 0.34
TYRO_HUMAN TYR Tyrosinase 3.978e-27 0.33
CAN2_PIG CAPN2 Calpain-2 catalytic subunit 4.851e-27 0.39
MMP2_HUMAN MMP2 72 kDa type IV collagenase 4.943e-27 0.47
CBPA1_HUMAN CPA1 Carboxypeptidase A1 1.027e-26 0.30
GHSR_HUMAN GHSR Growth hormone secretagogue receptor type 1 1.055e-26 0.54
ACE2_HUMAN ACE2 Angiotensin-converting enzyme 2 2.326e-26 0.30
Q95WR6_LEIDO Cysteine protease 5.312e-26 0.32
RENI_HUMAN REN Renin 7.399e-26 0.37
NMT_YEAST NMT1 Glycylpeptide N-tetradecanoyltransferase 3.546e-25 0.31
PLMN_HUMAN PLG Plasminogen 3.948e-25 0.43
PADI3_HUMAN PADI3 Protein-arginine deiminase type-3 4.124e-25 0.39
ADRM1_HUMAN ADRM1 Proteasomal ubiquitin receptor ADRM1 1.212e-24 0.32
PRS10_HUMAN PSMC6 26S proteasome regulatory subunit 10B 1.212e-24 0.32
PRS4_HUMAN PSMC1 26S proteasome regulatory subunit 4 1.212e-24 0.32
PRS6A_HUMAN PSMC3 26S proteasome regulatory subunit 6A 1.212e-24 0.32
PRS6B_HUMAN PSMC4 26S proteasome regulatory subunit 6B 1.212e-24 0.32
PRS7_HUMAN PSMC2 26S proteasome regulatory subunit 7 1.212e-24 0.32
PRS8_HUMAN PSMC5 26S proteasome regulatory subunit 8 1.212e-24 0.32
PSD11_HUMAN PSMD11 26S proteasome non-ATPase regulatory subunit 11 1.212e-24 0.32
PSD12_HUMAN PSMD12 26S proteasome non-ATPase regulatory subunit 12 1.212e-24 0.32
PSD13_HUMAN PSMD13 26S proteasome non-ATPase regulatory subunit 13 1.212e-24 0.32
PSMD1_HUMAN PSMD1 26S proteasome non-ATPase regulatory subunit 1 1.212e-24 0.32
PSMD2_HUMAN PSMD2 26S proteasome non-ATPase regulatory subunit 2 1.212e-24 0.32
PSMD3_HUMAN PSMD3 26S proteasome non-ATPase regulatory subunit 3 1.212e-24 0.32
PSMD4_HUMAN PSMD4 26S proteasome non-ATPase regulatory subunit 4 1.212e-24 0.32
PSMD6_HUMAN PSMD6 26S proteasome non-ATPase regulatory subunit 6 1.212e-24 0.32
PSMD7_HUMAN PSMD7 26S proteasome non-ATPase regulatory subunit 7 1.212e-24 0.32
PSMD8_HUMAN PSMD8 26S proteasome non-ATPase regulatory subunit 8 1.212e-24 0.32
SEM1_HUMAN SEM1 26S proteasome complex subunit SEM1 1.212e-24 0.32
CHIB_SERMA chiB Chitinase B 1.369e-24 0.32
KLK8_HUMAN KLK8 Kallikrein-8 2.139e-24 0.38
KLK5_HUMAN KLK5 Kallikrein-5 2.333e-24 0.33
MMP17_HUMAN MMP17 Matrix metalloproteinase-17 2.961e-24 0.47
NRP1_RAT Nrp1 Neuropilin-1 3.371e-24 0.32
MMP9_HUMAN MMP9 Matrix metalloproteinase-9 3.572e-24 0.47
STAT6_HUMAN STAT6 Signal transducer and activator of transcription 6 5.327e-24 0.39
AMPN_HUMAN ANPEP Aminopeptidase N 5.442e-24 0.56
PADI4_HUMAN PADI4 Protein-arginine deiminase type-4 5.714e-24 0.39
GNPAT_HUMAN GNPAT Dihydroxyacetone phosphate acyltransferase 6.321e-24 0.38
PGTB1_RAT Pggt1b Geranylgeranyl transferase type-1 subunit beta 8.433e-24 0.29
HPGDS_MOUSE Hpgds Hematopoietic prostaglandin D synthase 1.529e-23 0.29
Q3HTL5_PLAFA fp2B Falcipain 2B 2.063e-23 0.29
RIR1_MOUSE Rrm1 Ribonucleoside-diphosphate reductase large subunit 2.117e-23 0.29
CCNA2_HUMAN CCNA2 Cyclin-A2 2.29e-23 0.60
THRB_RAT F2 Prothrombin 4.618e-23 0.39
FSHR_RAT Fshr Follicle-stimulating hormone receptor 5.518e-23 0.28
PTPRC_HUMAN PTPRC Receptor-type tyrosine-protein phosphatase C 7.543e-23 0.33
TGM2_MOUSE Tgm2 Protein-glutamine gamma-glutamyltransferase 2 8.617e-23 0.36
KLK4_HUMAN KLK4 Kallikrein-4 2.043e-22 0.38
CCKAR_HUMAN CCKAR Cholecystokinin receptor type A 2.381e-22 0.43
SIR5_HUMAN SIRT5 NAD-dependent protein deacylase sirtuin-5, mitochondrial 2.521e-22 0.35
ACE_RAT Ace Angiotensin-converting enzyme 2.746e-22 0.38
CCKAR_RAT Cckar Cholecystokinin receptor type A 3.302e-22 0.43
PROC_HUMAN PROC Vitamin K-dependent protein C 5.046e-22 0.36
NEP_PIG MME Neprilysin 8.626e-22 0.34
FA11_HUMAN F11 Coagulation factor XI 2.464e-21 0.41
FA10_HUMAN F10 Coagulation factor X 9.593e-21 0.43
GRB2_HUMAN GRB2 Growth factor receptor-bound protein 2 2.506e-20 0.34
Q9NAW4_PLAFA Cysteine protease falcipain-3 3.527e-20 0.32
GLUT4_HUMAN SLC2A4 Solute carrier family 2, facilitated glucose transporter member 4 6.33e-20 0.32
TAT_HV1H2 tat Protein Tat 8.456e-20 0.31
EDNRA_MOUSE Ednra Endothelin-1 receptor 8.507e-20 0.33
PSA1_HUMAN PSMA1 Proteasome subunit alpha type-1 9.626e-20 0.40
PSA2_HUMAN PSMA2 Proteasome subunit alpha type-2 9.626e-20 0.40
PSA3_HUMAN PSMA3 Proteasome subunit alpha type-3 9.626e-20 0.40
PSA4_HUMAN PSMA4 Proteasome subunit alpha type-4 9.626e-20 0.40
PSA5_HUMAN PSMA5 Proteasome subunit alpha type-5 9.626e-20 0.40
PSA6_HUMAN PSMA6 Proteasome subunit alpha type-6 9.626e-20 0.40
PSA7_HUMAN PSMA7 Proteasome subunit alpha type-7 9.626e-20 0.40
PSB11_HUMAN PSMB11 Proteasome subunit beta type-11 9.626e-20 0.40
PSB3_HUMAN PSMB3 Proteasome subunit beta type-3 9.626e-20 0.40
PSB4_HUMAN PSMB4 Proteasome subunit beta type-4 9.626e-20 0.40
PSB6_HUMAN PSMB6 Proteasome subunit beta type-6 9.626e-20 0.40
PSB7_HUMAN PSMB7 Proteasome subunit beta type-7 9.626e-20 0.40
PSMA8_HUMAN PSMA8 Proteasome subunit alpha-type 8 9.626e-20 0.40
O31048_PORGN DPP IV Dipeptidyl peptidase IV 1.228e-19 0.37
LCAP_RAT Lnpep Leucyl-cystinyl aminopeptidase 2.677e-19 0.31
PEPT1_DERPT DERP1 Peptidase 1 2.928e-19 0.33
PSB10_HUMAN PSMB10 Proteasome subunit beta type-10 4.075e-19 0.40
RENI_RAT Ren1 Renin 4.142e-19 0.34
CATS_HUMAN CTSS Cathepsin S 9.003e-19 0.70
TRY1_BOVIN Cationic trypsin 1.074e-18 0.41
D5FGE8_TRYCR POT1.5 Putative amino acid permease/transporter 1.372e-18 0.29
PTN1_HUMAN PTPN1 Tyrosine-protein phosphatase non-receptor type 1 1.387e-18 0.40
Q94F81_MAIZE hda106 HD2 type histone deacetylase HDA106 1.557e-18 0.37
RIR1_MYCTU nrdE Ribonucleoside-diphosphate reductase subunit alpha 2.004e-18 0.29
AMD_HUMAN PAM Peptidyl-glycine alpha-amidating monooxygenase 2.947e-18 0.31
LY96_HUMAN LY96 Lymphocyte antigen 96 4.073e-18 0.35
AMP1_PLAFQ M1 family aminopeptidase 4.096e-18 0.44
LAT1_HUMAN SLC7A5 Large neutral amino acids transporter small subunit 1 4.879e-18 0.29
NEP_RAT Mme Neprilysin 7.577e-18 0.34
TRYB1_MOUSE Tpsab1 Tryptase 9.056e-18 0.28
TIMP3_RAT Timp3 Metalloproteinase inhibitor 3 1.368e-17 0.33
ITAV_HUMAN ITGAV Integrin alpha-V 2.17e-17 0.53
A5A4K8_RABIT MLNR Motilin receptor 3.311e-17 0.46
ANF_HUMAN NPPA Natriuretic peptides A 3.632e-17 0.34
ACHD_HUMAN CHRND Acetylcholine receptor subunit delta 3.696e-17 0.41
MMP14_HUMAN MMP14 Matrix metalloproteinase-14 3.939e-17 0.34
CCND1_HUMAN CCND1 G1/S-specific cyclin-D1 4.485e-17 0.58
C5AR1_HUMAN C5AR1 C5a anaphylatoxin chemotactic receptor 1 1.11e-16 0.39
CATH_HUMAN CTSH Pro-cathepsin H 2.22e-16 0.32
O07911_STAAU agrC AgrC 2.22e-16 0.31
PSB8_HUMAN PSMB8 Proteasome subunit beta type-8 2.22e-16 0.40
PTN9_HUMAN PTPN9 Tyrosine-protein phosphatase non-receptor type 9 2.22e-16 0.38
NRP1_HUMAN NRP1 Neuropilin-1 3.331e-16 0.34
PSB9_HUMAN PSMB9 Proteasome subunit beta type-9 3.331e-16 0.40
BMP1_HUMAN BMP1 Bone morphogenetic protein 1 1.11e-15 0.33
TRY1_RAT Prss1 Anionic trypsin-1 1.221e-15 0.39
UPAR_RAT Plaur Urokinase plasminogen activator surface receptor 1.221e-15 0.39
PEPA_PIG PGA Pepsin A 1.332e-15 0.31
SSR2_HUMAN SSTR2 Somatostatin receptor type 2 2.22e-15 0.33
OST48_HUMAN DDOST Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit 2.665e-15 0.30
PAO1_MAIZE MPAO1 Polyamine oxidase 1 3.109e-15 0.31
GRIA3_HUMAN GRIA3 Glutamate receptor 3 3.22e-15 0.39
Q9N6S8_PLAFA Cysteine proteinase falcipain 2a 3.22e-15 0.35
ITB1_HUMAN ITGB1 Integrin beta-1 4.33e-15 0.42
XIAP_HUMAN XIAP E3 ubiquitin-protein ligase XIAP 4.996e-15 0.40
SSR2_MOUSE Sstr2 Somatostatin receptor type 2 6.217e-15 0.28
HPGDS_HUMAN HPGDS Hematopoietic prostaglandin D synthase 6.661e-15 0.36
AMPE_HUMAN ENPEP Glutamyl aminopeptidase 6.772e-15 0.33
ECE1_HUMAN ECE1 Endothelin-converting enzyme 1 9.104e-15 0.36
NMDZ1_RAT Grin1 Glutamate receptor ionotropic, NMDA 1 9.548e-15 0.44
OPRX_HUMAN OPRL1 Nociceptin receptor 1.177e-14 0.69
ACE2_RAT Ace2 Angiotensin-converting enzyme 2 1.488e-14 0.32
DHYS_RAT Dhps Deoxyhypusine synthase 1.61e-13 0.29
MMP7_HUMAN MMP7 Matrilysin 1.645e-13 0.38
KAPCA_HUMAN PRKACA cAMP-dependent protein kinase catalytic subunit alpha 4.576e-13 0.45
PEPA1_PENJA Penicillopepsin-1 4.607e-13 0.28
ANPRA_HUMAN NPR1 Atrial natriuretic peptide receptor 1 6.246e-13 0.29
CASP1_HUMAN CASP1 Caspase-1 6.53e-13 0.33
GSP_CRIFA GSP Glutathionylspermidine synthase 6.861e-13 0.32
PADI2_HUMAN PADI2 Protein-arginine deiminase type-2 8.722e-13 0.38
AMPX_VIBPR Bacterial leucyl aminopeptidase 1.532e-12 0.31
CBPB2_HUMAN CPB2 Carboxypeptidase B2 1.728e-12 0.45
AMPB_HUMAN RNPEP Aminopeptidase B 2.492e-12 0.33
LSHR_RAT Lhcgr Lutropin-choriogonadotropic hormone receptor 2.937e-12 0.29
KLK2_HUMAN KLK2 Kallikrein-2 3.4e-12 0.30
DRB3_HUMAN HLA-DRB3 HLA class II histocompatibility antigen, DR beta 3 chain 5.433e-12 0.32
AMPL_HUMAN LAP3 Cytosol aminopeptidase 6.932e-12 0.32
ITB3_HUMAN ITGB3 Integrin beta-3 1.284e-11 0.53
CATG_HUMAN CTSG Cathepsin G 1.462e-11 0.37
CATD_HUMAN CTSD Cathepsin D 1.991e-11 0.46
AMPN_MOUSE Anpep Aminopeptidase N 2.083e-11 0.31
TRY1_HUMAN PRSS1 Trypsin-1 2.923e-11 0.37
TRY3_HUMAN PRSS3 Trypsin-3 3.001e-11 0.30
KLK7_HUMAN KLK7 Kallikrein-7 3.335e-11 0.33
CXCR4_HUMAN CXCR4 C-X-C chemokine receptor type 4 6.371e-11 0.35
Q9NBA7_PLAFA Cysteine protease falcipain-3 7.173e-11 0.29
HMDH_HUMAN HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase 7.681e-11 0.40
CMA1_HUMAN CMA1 Chymase 8.972e-11 0.33
ACE_RABIT ACE Angiotensin-converting enzyme 1.199e-10 0.36
NOS1_HUMAN NOS1 Nitric oxide synthase, brain 1.556e-10 0.42
DSBA_ECOLI dsbA Thiol:disulfide interchange protein DsbA 2.131e-10 0.30
GRIK1_RAT Grik1 Glutamate receptor ionotropic, kainate 1 2.135e-10 0.38
ITA2B_HUMAN ITGA2B Integrin alpha-IIb 2.558e-10 0.53
DPP2_HUMAN DPP7 Dipeptidyl peptidase 2 2.895e-10 0.38
Q9YQ12_9HIV1 protease Protease 4.061e-10 0.52
TPA_HUMAN PLAT Tissue-type plasminogen activator 7.098e-10 0.36
TERT_HUMAN TERT Telomerase reverse transcriptase 8.47e-10 0.37
PTN2_HUMAN PTPN2 Tyrosine-protein phosphatase non-receptor type 2 8.909e-10 0.40
MMP13_HUMAN MMP13 Collagenase 3 8.96e-10 0.42
NTR2_RAT Ntsr2 Neurotensin receptor type 2 1.193e-09 0.41
NK1R_HUMAN TACR1 Substance-P receptor 1.239e-09 0.57
CATL2_HUMAN CTSV Cathepsin L2 1.338e-09 0.30
FA12_HUMAN F12 Coagulation factor XII 1.433e-09 0.43
NMBR_HUMAN NMBR Neuromedin-B receptor 1.491e-09 0.31
CASP9_HUMAN CASP9 Caspase-9 2.391e-09 0.32
FPRS1_MOUSE Fpr-s1 Formyl peptide receptor-related sequence 1 4.561e-09 0.36
ASAH1_HUMAN ASAH1 Acid ceramidase 5.386e-09 0.30
KMT2A_HUMAN KMT2A Histone-lysine N-methyltransferase 2A 6.704e-09 0.32
NOS1_RAT Nos1 Nitric oxide synthase, brain 8.281e-09 0.42
KEAP1_HUMAN KEAP1 Kelch-like ECH-associated protein 1 8.934e-09 0.31
CALRL_RAT Calcrl Calcitonin gene-related peptide type 1 receptor 1.69e-08 0.28
SPP2A_HUMAN SPPL2A Signal peptide peptidase-like 2A 2.98e-08 0.32
LKHA4_HUMAN LTA4H Leukotriene A-4 hydrolase 3.14e-08 0.40
CTRC_HUMAN CTRC Chymotrypsin-C 4.098e-08 0.32
CASP3_HUMAN CASP3 Caspase-3 5.232e-08 0.44
IL2RA_MOUSE Il2ra Interleukin-2 receptor subunit alpha 5.301e-08 0.28
HYES_MOUSE Ephx2 Bifunctional epoxide hydrolase 2 5.765e-08 0.33
UR2R_RAT Uts2r Urotensin-2 receptor 7.384e-08 0.49
DPP8_HUMAN DPP8 Dipeptidyl peptidase 8 7.457e-08 0.38
CYSK_MYCTU cysK1 O-acetylserine sulfhydrylase 8.53e-08 0.35
GSTO1_HUMAN GSTO1 Glutathione S-transferase omega-1 1.102e-07 0.32
AKT3_HUMAN AKT3 RAC-gamma serine/threonine-protein kinase 1.134e-07 0.45
FNTA_BOVIN FNTA Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha 1.336e-07 0.35
TRY2_BOVIN Anionic trypsin 1.402e-07 0.34
ITB8_HUMAN ITGB8 Integrin beta-8 1.417e-07 0.32
CDK2_HUMAN CDK2 Cyclin-dependent kinase 2 1.495e-07 0.58
NOD2_HUMAN NOD2 Nucleotide-binding oligomerization domain-containing protein 2 1.662e-07 0.34
PSA_HUMAN NPEPPS Puromycin-sensitive aminopeptidase 1.698e-07 0.31
FA10_BOVIN F10 Coagulation factor X 1.828e-07 0.39
STAT3_MOUSE Stat3 Signal transducer and activator of transcription 3 1.911e-07 0.29
UROK_HUMAN PLAU Urokinase-type plasminogen activator 2.036e-07 0.38
ACPS_BACSU acpS Holo-[acyl-carrier-protein] synthase 2.542e-07 0.30
PGTB1_BOVIN PGGT1B Geranylgeranyl transferase type-1 subunit beta 2.763e-07 0.33
PSDE_HUMAN PSMD14 26S proteasome non-ATPase regulatory subunit 14 3.218e-07 0.32
ITA5_HUMAN ITGA5 Integrin alpha-5 3.278e-07 0.39
CTRA_BOVIN Chymotrypsinogen A 4.055e-07 0.30
ECE1_RAT Ece1 Endothelin-converting enzyme 1 4.422e-07 0.31
CPNS1_HUMAN CAPNS1 Calpain small subunit 1 5.094e-07 0.32
CDK4_HUMAN CDK4 Cyclin-dependent kinase 4 6.023e-07 0.58
NK2R_RABIT TACR2 Substance-K receptor 7.068e-07 0.34
PIN1_HUMAN PIN1 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 7.781e-07 0.40
FOLH1_HUMAN FOLH1 Glutamate carboxypeptidase 2 9.003e-07 0.30
CELA1_HUMAN CELA1 Chymotrypsin-like elastase family member 1 9.215e-07 0.30
OPRX_CAVPO OPRL1 Nociceptin receptor 9.501e-07 0.31
CBPN_HUMAN CPN1 Carboxypeptidase N catalytic chain 9.973e-07 0.28
5HT1D_CAVPO HTR1D 5-hydroxytryptamine receptor 1D 1.092e-06 0.28
MEN1_HUMAN MEN1 Menin 1.15e-06 0.40
CATK_RABIT CTSK Cathepsin K 1.626e-06 0.35
CA2D1_MOUSE Cacna2d1 Voltage-dependent calcium channel subunit alpha-2/delta-1 1.831e-06 0.30
THRB_BOVIN F2 Prothrombin 1.935e-06 0.36
GASR_MOUSE Cckbr Gastrin/cholecystokinin type B receptor 2.877e-06 0.43
GNRHR_RAT Gnrhr Gonadotropin-releasing hormone receptor 3.078e-06 0.33
CEL2A_PIG CELA2A Chymotrypsin-like elastase family member 2A 3.442e-06 0.28
BACE1_HUMAN BACE1 Beta-secretase 1 4.032e-06 0.36
FAS_HUMAN FASN Fatty acid synthase 4.257e-06 0.36
LSHR_HUMAN LHCGR Lutropin-choriogonadotropic hormone receptor 4.325e-06 0.29
S6A12_MOUSE Slc6a12 Sodium- and chloride-dependent betaine transporter 4.957e-06 0.28
CAC1B_HUMAN CACNA1B Voltage-dependent N-type calcium channel subunit alpha-1B 5.192e-06 0.30
BIRC3_HUMAN BIRC3 Baculoviral IAP repeat-containing protein 3 5.25e-06 0.30
CTRB1_HUMAN CTRB1 Chymotrypsinogen B 6.364e-06 0.29
MC5R_HUMAN MC5R Melanocortin receptor 5 7.046e-06 0.46
PTPRA_HUMAN PTPRA Receptor-type tyrosine-protein phosphatase alpha 9.43e-06 0.32

Setmelanotide

MC5R_MOUSE Mc5r Melanocortin receptor 5 2.958e-214 0.47
MC4R_MOUSE Mc4r Melanocortin receptor 4 5.631e-190 0.47
MSHR_HUMAN MC1R Melanocyte-stimulating hormone receptor 1.902e-172 0.68
MC3R_MOUSE Mc3r Melanocortin receptor 3 5.316e-159 0.47
MSHR_MOUSE Mc1r Melanocyte-stimulating hormone receptor 3.46e-134 0.61
MC3R_HUMAN MC3R Melanocortin receptor 3 7.711e-133 0.61
MC4R_HUMAN MC4R Melanocortin receptor 4 4.54e-100 0.68
NK2R_RABIT TACR2 Substance-K receptor 4.105e-87 0.36
EDNRA_PIG EDNRA Endothelin-1 receptor 6.989e-86 0.43
CD36_RAT Cd36 Platelet glycoprotein 4 4.131e-83 0.35
SSR5_RAT Sstr5 Somatostatin receptor type 5 1.896e-82 0.50
V2R_PIG AVPR2 Vasopressin V2 receptor 5.595e-70 0.37
CADH2_HUMAN CDH2 Cadherin-2 1.069e-63 0.51
EDNRA_MOUSE Ednra Endothelin-1 receptor 2.423e-62 0.34
O07911_STAAU agrC AgrC 3.809e-58 0.35
C5AR1_HUMAN C5AR1 C5a anaphylatoxin chemotactic receptor 1 1.119e-53 0.60
EDNRB_RAT Ednrb Endothelin receptor type B 3.212e-53 0.34
NK2R_MESAU TACR2 Substance-K receptor 2.164e-52 0.36
NK2R_HUMAN TACR2 Substance-K receptor 3.865e-47 0.41
UR2R_RAT Uts2r Urotensin-2 receptor 3.46e-46 0.60
LSHR_RAT Lhcgr Lutropin-choriogonadotropic hormone receptor 3.587e-46 0.34
MC5R_HUMAN MC5R Melanocortin receptor 5 9.637e-46 0.58
RIR1_MYCTU nrdE Ribonucleoside-diphosphate reductase subunit alpha 1.872e-38 0.34
MAGI3_HUMAN MAGI3 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 3.877e-38 0.29
CCKAR_MOUSE Cckar Cholecystokinin receptor type A 4.949e-36 0.34
PLMN_BOVIN PLG Plasminogen 1.65e-35 0.31
NCOR2_HUMAN NCOR2 Nuclear receptor corepressor 2 2.246e-34 0.38
SSR2_HUMAN SSTR2 Somatostatin receptor type 2 2.367e-32 0.53
OPRM_RAT Oprm1 Mu-type opioid receptor 5.577e-32 0.46
V2R_BOVIN AVPR2 Vasopressin V2 receptor 9.081e-31 0.38
OPRD_MOUSE Oprd1 Delta-type opioid receptor 4.357e-30 0.39
OPRM_CAVPO OPRM1 Mu-type opioid receptor 7.048e-30 0.43
SSR4_HUMAN SSTR4 Somatostatin receptor type 4 9.225e-30 0.48
OPRD_RAT Oprd1 Delta-type opioid receptor 2.194e-29 0.44
CXCR4_HUMAN CXCR4 C-X-C chemokine receptor type 4 2.944e-29 0.54
CHIB_SERMA chiB Chitinase B 4.902e-29 0.37
GASR_HUMAN CCKBR Gastrin/cholecystokinin type B receptor 2.994e-28 0.36
FSHR_RAT Fshr Follicle-stimulating hormone receptor 1.239e-26 0.33
CCKAR_CAVPO CCKAR Cholecystokinin receptor type A 1.874e-26 0.32
SSR2_MOUSE Sstr2 Somatostatin receptor type 2 5.698e-26 0.50
NK2R_RAT Tacr2 Substance-K receptor 1.154e-24 0.38
GASR_RAT Cckbr Gastrin/cholecystokinin type B receptor 1.861e-24 0.33
CP125_MYCTU cyp125 Steroid C26-monooxygenase 1.839e-23 0.29
NMBR_RAT Nmbr Neuromedin-B receptor 2.847e-23 0.29
GRPR_RAT Grpr Gastrin-releasing peptide receptor 7.812e-22 0.31
SPSB2_HUMAN SPSB2 SPRY domain-containing SOCS box protein 2 2.036e-21 0.34
NTR1_MOUSE Ntsr1 Neurotensin receptor type 1 4.387e-20 0.35
HGFA_HUMAN HGFAC Hepatocyte growth factor activator 6.831e-20 0.33
ITA2B_HUMAN ITGA2B Integrin alpha-IIb 7.077e-20 0.43
BKRB2_RABIT BDKRB2 B2 bradykinin receptor 8.392e-20 0.30
NK3R_RAT Tacr3 Neuromedin-K receptor 1.222e-19 0.36
ITB3_HUMAN ITGB3 Integrin beta-3 2.201e-19 0.43
DSBA_ECOLI dsbA Thiol:disulfide interchange protein DsbA 2.23e-19 0.30
CBPN_HUMAN CPN1 Carboxypeptidase N catalytic chain 3.659e-19 0.29
EDNRA_HUMAN EDNRA Endothelin-1 receptor 4.321e-19 0.37
ECE1_BOVIN ECE1 Endothelin-converting enzyme 1 2.139e-18 0.29
SSR1_HUMAN SSTR1 Somatostatin receptor type 1 5.073e-18 0.48
KISSR_HUMAN KISS1R KiSS-1 receptor 2.519e-17 0.30
NK1R_CAVPO TACR1 Substance-P receptor 3.655e-17 0.36
NPFF2_RAT Npffr2 Neuropeptide FF receptor 2 4.445e-17 0.30
GRPR_MOUSE Grpr Gastrin-releasing peptide receptor 4.894e-17 0.33
SSR5_HUMAN SSTR5 Somatostatin receptor type 5 5.103e-17 0.53
SSR3_HUMAN SSTR3 Somatostatin receptor type 3 1.11e-16 0.53
CFAB_HUMAN CFB Complement factor B 3.442e-15 0.31
V1BR_HUMAN AVPR1B Vasopressin V1b receptor 2.32e-14 0.37
HDAC3_HUMAN HDAC3 Histone deacetylase 3 2.975e-14 0.38
HEPS_HUMAN HPN Serine protease hepsin 4.263e-14 0.33
CCKAR_RAT Cckar Cholecystokinin receptor type A 6.306e-14 0.33
CHIB1_ASPFM chiB1 Endochitinase B1 8.116e-14 0.30
ITAV_HUMAN ITGAV Integrin alpha-V 2.613e-13 0.39
OXYR_HUMAN OXTR Oxytocin receptor 8.432e-13 0.39
MRP2_RAT Abcc2 Canalicular multispecific organic anion transporter 1 2.276e-12 0.29
UR2R_HUMAN UTS2R Urotensin-2 receptor 2.744e-12 0.39
ACKR3_HUMAN ACKR3 Atypical chemokine receptor 3 3.063e-12 0.40
AGRA_STAAU agrA Accessory gene regulator protein A 3.144e-12 0.30
ITB5_HUMAN ITGB5 Integrin beta-5 5.423e-12 0.39
ASH2L_HUMAN ASH2L Set1/Ash2 histone methyltransferase complex subunit ASH2 5.866e-12 0.32
RBBP5_HUMAN RBBP5 Retinoblastoma-binding protein 5 5.866e-12 0.32
BIRC3_HUMAN BIRC3 Baculoviral IAP repeat-containing protein 3 2.111e-11 0.30
ITA5_HUMAN ITGA5 Integrin alpha-5 7.985e-11 0.38
POLG_DEN26 Genome polyprotein 1.002e-10 0.34
OPRD_HUMAN OPRD1 Delta-type opioid receptor 1.111e-10 0.43
NMUR1_HUMAN NMUR1 Neuromedin-U receptor 1 1.274e-10 0.31
Q6MGC4_RAT Pfdn6 H2-K region expressed gene 2, rat orthologue 1.406e-10 0.29
ST14_MOUSE St14 Suppressor of tumorigenicity 14 protein homolog 1.936e-10 0.30
CHIA_SERMA chiA Chitinase A 2.368e-10 0.30
HDAC8_HUMAN HDAC8 Histone deacetylase 8 2.564e-10 0.38
GHSR_HUMAN GHSR Growth hormone secretagogue receptor type 1 2.833e-10 0.36
OPRK_CAVPO OPRK1 Kappa-type opioid receptor 4.203e-10 0.39
NMUR2_HUMAN NMUR2 Neuromedin-U receptor 2 6.936e-10 0.31
OPRK_HUMAN OPRK1 Kappa-type opioid receptor 9.277e-10 0.44
CCKAR_HUMAN CCKAR Cholecystokinin receptor type A 9.461e-10 0.32
OPRM_HUMAN OPRM1 Mu-type opioid receptor 1.127e-09 0.40
BRS3_HUMAN BRS3 Bombesin receptor subtype-3 1.697e-09 0.30
V2R_RAT Avpr2 Vasopressin V2 receptor 1.78e-09 0.39
KMT2A_HUMAN KMT2A Histone-lysine N-methyltransferase 2A 4.483e-09 0.32
ANPRC_HUMAN NPR3 Atrial natriuretic peptide receptor 3 5.099e-09 0.30
V1AR_RAT Avpr1a Vasopressin V1a receptor 5.428e-09 0.33
HDA11_HUMAN HDAC11 Histone deacetylase 11 5.686e-09 0.37
V2R_HUMAN AVPR2 Vasopressin V2 receptor 6.72e-09 0.37
V1BR_RAT Avpr1b Vasopressin V1b receptor 7.586e-09 0.30
ITB6_HUMAN ITGB6 Integrin beta-6 8.73e-09 0.38
V1AR_HUMAN AVPR1A Vasopressin V1a receptor 8.737e-09 0.41
GASR_BOVIN CCKBR Gastrin/cholecystokinin type B receptor 9.601e-09 0.29
MMP11_MOUSE Mmp11 Stromelysin-3 1.531e-08 0.32
ST14_HUMAN ST14 Suppressor of tumorigenicity 14 protein 1.774e-08 0.33
C3AR_HUMAN C3AR1 C3a anaphylatoxin chemotactic receptor 2.223e-08 0.31
PAPA1_CARPA Papain 2.294e-08 0.35
OPRK_RAT Oprk1 Kappa-type opioid receptor 3.439e-08 0.32
OXYR_RAT Oxtr Oxytocin receptor 6.433e-08 0.33
SIR3_HUMAN SIRT3 NAD-dependent protein deacetylase sirtuin-3, mitochondrial 1.021e-07 0.30
A0A286XTF2_CAVPO OPRD1 G_PROTEIN_RECEP_F1_2 domain-containing protein 1.096e-07 0.32
ECE1_HUMAN ECE1 Endothelin-converting enzyme 1 1.265e-07 0.29
NK1R_HUMAN TACR1 Substance-P receptor 1.997e-07 0.36
HDA10_HUMAN HDAC10 Polyamine deacetylase HDAC10 2.348e-07 0.37
NMBR_HUMAN NMBR Neuromedin-B receptor 2.409e-07 0.29
CBPA1_HUMAN CPA1 Carboxypeptidase A1 3.174e-07 0.29
HDAC2_HUMAN HDAC2 Histone deacetylase 2 4.816e-07 0.37
GASR_MOUSE Cckbr Gastrin/cholecystokinin type B receptor 5.859e-07 0.34
RENI_HUMAN REN Renin 5.907e-07 0.37
DRB3_HUMAN HLA-DRB3 HLA class II histocompatibility antigen, DR beta 3 chain 7.474e-07 0.33
CATB_BOVIN CTSB Cathepsin B 9.562e-07 0.31
HDAC1_HUMAN HDAC1 Histone deacetylase 1 1.244e-06 0.38
P96830_MYCTO TYR_PHOSPHATASE_2 domain-containing protein 1.287e-06 0.34
CBX7_HUMAN CBX7 Chromobox protein homolog 7 1.356e-06 0.31
PAR1_HUMAN F2R Proteinase-activated receptor 1 1.834e-06 0.31
RENI_RAT Ren1 Renin 2.337e-06 0.34
GRB2_HUMAN GRB2 Growth factor receptor-bound protein 2 3.162e-06 0.36
SIR1_HUMAN SIRT1 NAD-dependent protein deacetylase sirtuin-1 3.282e-06 0.30
GNRHR_RAT Gnrhr Gonadotropin-releasing hormone receptor 5.057e-06 0.41
CHIA_HUMAN CHIA Acidic mammalian chitinase 8.294e-06 0.30

Naldemedine

OPRK_CAVPO OPRK1 Kappa-type opioid receptor 3.506e-179 0.59
OPRD_HUMAN OPRD1 Delta-type opioid receptor 2.564e-174 0.56
OPRM_MOUSE Oprm1 Mu-type opioid receptor 3.144e-163 0.55
OPRK_HUMAN OPRK1 Kappa-type opioid receptor 2.471e-157 0.56
OPRK_MOUSE Oprk1 Kappa-type opioid receptor 1.605e-139 0.56
OPRM_HUMAN OPRM1 Mu-type opioid receptor 4.167e-133 0.56
OPRM_CAVPO OPRM1 Mu-type opioid receptor 9.875e-124 0.56
OPRD_MOUSE Oprd1 Delta-type opioid receptor 2.335e-120 0.56
OPRD_RAT Oprd1 Delta-type opioid receptor 1.734e-118 0.75
OPRM_BOVIN OPRM1 Mu-type opioid receptor 2.38e-104 0.46
OPRM_RAT Oprm1 Mu-type opioid receptor 2.797e-102 0.75
OPRK_RAT Oprk1 Kappa-type opioid receptor 8.447e-66 0.56
TLR4_MOUSE Tlr4 Toll-like receptor 4 7.596e-43 0.43
OPRX_CAVPO OPRL1 Nociceptin receptor 1.029e-20 0.44
OPRX_HUMAN OPRL1 Nociceptin receptor 2.483e-20 0.53
OGRL1_HUMAN OGFRL1 Opioid growth factor receptor-like protein 1 3.397e-14 0.39
HDAC4_HUMAN HDAC4 Histone deacetylase 4 6.899e-13 0.33

Lasmiditan

ACKR3_HUMAN ACKR3 Atypical chemokine receptor 3 3.852e-173 0.43
5HT1F_HUMAN HTR1F 5-hydroxytryptamine receptor 1F 8.843e-152 0.73
SORT_HUMAN SORT1 Sortilin 1.193e-45 0.33
KC1E_HUMAN CSNK1E Casein kinase I isoform epsilon 1.921e-28 0.36
WNT3A_MOUSE Wnt3a Protein Wnt-3a 7.783e-22 0.32
KC1D_HUMAN CSNK1D Casein kinase I isoform delta 1.327e-20 0.36
VACHT_HUMAN SLC18A3 Vesicular acetylcholine transporter 1.847e-20 0.32
GRM5_RAT Grm5 Metabotropic glutamate receptor 5 6.956e-20 0.42
MK14_HUMAN MAPK14 Mitogen-activated protein kinase 14 2.983e-19 0.37
ENV_HV1Y2 env Envelope glycoprotein gp160 6.976e-19 0.34
5HT1B_HUMAN HTR1B 5-hydroxytryptamine receptor 1B 2.274e-18 0.45
5HT1D_HUMAN HTR1D 5-hydroxytryptamine receptor 1D 3.476e-18 0.45
TRPV4_RAT Trpv4 Transient receptor potential cation channel subfamily V member 4 9.992e-16 0.30
MK10_HUMAN MAPK10 Mitogen-activated protein kinase 10 2.109e-15 0.32
CCNA1_HUMAN CCNA1 Cyclin-A1 2.998e-15 0.37
GRM5_HUMAN GRM5 Metabotropic glutamate receptor 5 3.553e-15 0.41
MALT1_HUMAN MALT1 Mucosa-associated lymphoid tissue lymphoma translocation protein 1 7.772e-15 0.30
EFC4B_HUMAN CRACR2A EF-hand calcium-binding domain-containing protein 4B 1.066e-14 0.33
DCNL1_HUMAN DCUN1D1 DCN1-like protein 1 1.221e-14 0.32
5HT2C_RAT Htr2c 5-hydroxytryptamine receptor 2C 1.898e-14 0.44
WDR5_HUMAN WDR5 WD repeat-containing protein 5 1.614e-13 0.31
CCNA2_HUMAN CCNA2 Cyclin-A2 2.831e-13 0.37
ACH10_RAT Chrna10 Neuronal acetylcholine receptor subunit alpha-10 2.334e-12 0.29
CCR3_HUMAN CCR3 C-C chemokine receptor type 3 2.927e-12 0.36
5HT2B_RAT Htr2b 5-hydroxytryptamine receptor 2B 5.747e-12 0.31
VMAT2_MOUSE Slc18a2 Synaptic vesicular amine transporter 8.165e-12 0.29
5HT3B_MOUSE Htr3b 5-hydroxytryptamine receptor 3B 1.15e-11 0.28
TYK2_HUMAN TYK2 Non-receptor tyrosine-protein kinase TYK2 2.161e-11 0.33
RORB_HUMAN RORB Nuclear receptor ROR-beta 2.366e-11 0.32
5HT2A_RAT Htr2a 5-hydroxytryptamine receptor 2A 3.618e-11 0.40
5HT1A_HUMAN HTR1A 5-hydroxytryptamine receptor 1A 3.874e-11 0.45
RIPK1_MOUSE Ripk1 Receptor-interacting serine/threonine-protein kinase 1 2.313e-10 0.29
MCHR1_HUMAN MCHR1 Melanin-concentrating hormone receptor 1 3.381e-10 0.33
DHB14_HUMAN HSD17B14 17-beta-hydroxysteroid dehydrogenase 14 1.132e-09 0.37
TRPV4_HUMAN TRPV4 Transient receptor potential cation channel subfamily V member 4 1.439e-09 0.35
RORA_HUMAN RORA Nuclear receptor ROR-alpha 1.448e-09 0.32
SC5A7_HUMAN SLC5A7 High affinity choline transporter 1 1.751e-09 0.30
GPR6_HUMAN GPR6 G-protein coupled receptor 6 8.178e-09 0.33
ABL1_HUMAN ABL1 Tyrosine-protein kinase ABL1 8.507e-09 0.40
CAC1G_HUMAN CACNA1G Voltage-dependent T-type calcium channel subunit alpha-1G 1.409e-08 0.31
VACHT_TETCF Vesicular acetylcholine transporter 1.775e-08 0.31
5HT2C_HUMAN HTR2C 5-hydroxytryptamine receptor 2C 3.02e-08 0.42
HRH4_MOUSE Hrh4 Histamine H4 receptor 3.186e-08 0.31
SMN_HUMAN SMN1; SMN2 Survival motor neuron protein 3.347e-08 0.28
UBP47_HUMAN USP47 Ubiquitin carboxyl-terminal hydrolase 47 3.998e-08 0.30
CCR3_RAT Ccr3 C-C chemokine receptor type 3 4.652e-08 0.30
VMAT2_HUMAN SLC18A2 Synaptic vesicular amine transporter 9.239e-08 0.29
5HT1E_HUMAN HTR1E 5-hydroxytryptamine receptor 1E 2.958e-07 0.42
FGF2_HUMAN FGF2 Fibroblast growth factor 2 3.544e-07 0.29
CCR3_MOUSE Ccr3 Probable C-C chemokine receptor type 3 3.634e-07 0.30
LIMK2_HUMAN LIMK2 LIM domain kinase 2 6.002e-07 0.31
ILVB_ARATH ALS Acetolactate synthase, chloroplastic 6.968e-07 0.28
SGMR1_CAVPO SIGMAR1 Sigma non-opioid intracellular receptor 1 7.352e-07 0.32
ABL1_MOUSE Abl1 Tyrosine-protein kinase ABL1 9.396e-07 0.29
PPBI_MOUSE Iap Intestinal-type alkaline phosphatase 1.173e-06 0.33
ACOD1_MOUSE Scd1 Acyl-CoA desaturase 1 1.245e-06 0.32
DHI1_HUMAN HSD11B1 Corticosteroid 11-beta-dehydrogenase isozyme 1 1.401e-06 0.37
CD5R1_HUMAN CDK5R1 Cyclin-dependent kinase 5 activator 1 1.734e-06 0.34
CDK2_HUMAN CDK2 Cyclin-dependent kinase 2 1.772e-06 0.40
M3K5_HUMAN MAP3K5 Mitogen-activated protein kinase kinase kinase 5 2.769e-06 0.32
PIM3_HUMAN PIM3 Serine/threonine-protein kinase pim-3 3.014e-06 0.34
RPA1_HUMAN POLR1A DNA-directed RNA polymerase I subunit RPA1 5.186e-06 0.29
5HT2A_HUMAN HTR2A 5-hydroxytryptamine receptor 2A 7.881e-06 0.42
NPY5R_MOUSE Npy5r Neuropeptide Y receptor type 5 8.102e-06 0.32
NTRK1_HUMAN NTRK1 High affinity nerve growth factor receptor 9.36e-06 0.32

Clobetasol

ATTY_RAT Tat Tyrosine aminotransferase 5.033e-159 0.60
GCR_RAT Nr3c1 Glucocorticoid receptor 1.373e-102 0.85
Q690N0_BOVIN PGR Progesterone receptor 1.071e-59 0.85
GCR_HUMAN NR3C1 Glucocorticoid receptor 6.867e-49 0.85
CBG_HUMAN SERPINA6 Corticosteroid-binding globulin 1.3e-21 0.42
GCR_MOUSE Nr3c1 Glucocorticoid receptor 3.603e-20 0.54
FABPL_RAT Fabp1 Fatty acid-binding protein, liver 1.346e-11 0.37
GLNA_HUMAN GLUL Glutamine synthetase 1.346e-11 0.37
IL6_HUMAN IL6 Interleukin-6 2.916e-09 0.37
SHBG_HUMAN SHBG Sex hormone-binding globulin 9.819e-09 0.31
MMP1_HUMAN MMP1 Interstitial collagenase 1.64e-08 0.62

Telotristat_ethyl

TPH1_HUMAN TPH1 Tryptophan 5-hydroxylase 1 5.889e-145 0.87
TPH1_RAT Tph1 Tryptophan 5-hydroxylase 1 2.172e-108 0.62
TPH2_HUMAN TPH2 Tryptophan 5-hydroxylase 2 1.29e-104 0.62
GBRB2_HUMAN GABRB2 Gamma-aminobutyric acid receptor subunit beta-2 1.11e-16 0.33
PLCB_HUMAN AGPAT2 1-acyl-sn-glycerol-3-phosphate acyltransferase beta 1.038e-08 0.32
GBRA2_HUMAN GABRA2 Gamma-aminobutyric acid receptor subunit alpha-2 6.822e-08 0.33
GBRG2_HUMAN GABRG2 Gamma-aminobutyric acid receptor subunit gamma-2 6.518e-06 0.33

Dopexamine

ADRB1_MOUSE Adrb1 Beta-1 adrenergic receptor 4.129e-112 0.61
ADRB2_HUMAN ADRB2 Beta-2 adrenergic receptor 2.282e-70 0.61
ASAH1_HUMAN ASAH1 Acid ceramidase 3.185e-69 0.36
TYTR_CRIFA TPR Trypanothione reductase 1.885e-68 0.55
ADRB1_HUMAN ADRB1 Beta-1 adrenergic receptor 3.839e-59 0.48
TYTR_TRYCR TPR Trypanothione reductase 1.073e-49 0.55
GRIA1_RAT Gria1 Glutamate receptor 1 2.849e-49 0.40
ERCC1_HUMAN ERCC1 DNA excision repair protein ERCC-1 1.243e-46 0.49
XPF_HUMAN ERCC4 DNA repair endonuclease XPF 1.243e-46 0.49
GNRHR_RAT Gnrhr Gonadotropin-releasing hormone receptor 6.567e-44 0.43
ADRB3_HUMAN ADRB3 Beta-3 adrenergic receptor 1.228e-41 0.41
SC6A5_HUMAN SLC6A5 Sodium- and chloride-dependent glycine transporter 2 2.089e-41 0.41
CRTM_STAAU crtM 4,4'-diapophytoene synthase 2.028e-39 0.35
MGRA_STAAU mgrA HTH-type transcriptional regulator MgrA 3.875e-36 0.29
TAAR1_HUMAN TAAR1 Trace amine-associated receptor 1 4.116e-36 0.39
ARP19_RAT Arpp19 cAMP-regulated phosphoprotein 19 1.012e-35 0.44
M9TGV3_MYCTX inhA Enoyl-[acyl-carrier-protein] reductase [NADH] 6.605e-34 0.38
PERM_HUMAN MPO Myeloperoxidase 3.594e-33 0.51
LX15B_RAT Alox15b Arachidonate 15-lipoxygenase B 3.966e-30 0.34
ADRB2_CAVPO Adrb2 Beta-2 adrenergic receptor 4.903e-30 0.41
LOX15_RAT Alox15 Arachidonate 15-lipoxygenase 5.849e-30 0.34
GRIA1_HUMAN GRIA1 Glutamate receptor 1 1.475e-29 0.40
PLCG1_BOVIN PLCG1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 2.535e-29 0.29
LOX15_HUMAN ALOX15 Arachidonate 15-lipoxygenase 5.429e-28 0.67
A0A0C7ACN7_PSEAI pqsD 3-oxoacyl-ACP synthase 2.081e-26 0.45
S6A13_MOUSE Slc6a13 Sodium- and chloride-dependent GABA transporter 2 2.301e-26 0.38
AMP1_PLAFQ M1 family aminopeptidase 2.113e-24 0.32
NOS3_BOVIN NOS3 Nitric oxide synthase, endothelial 3.673e-24 0.36
NANA_STREE nanA Sialidase A 6.402e-24 0.43
INHA_MYCTU inhA Enoyl-[acyl-carrier-protein] reductase [NADH] 7.566e-24 0.38
SCN2A_HUMAN SCN2A Sodium channel protein type 2 subunit alpha 1.643e-22 0.31
Q39829_SOYBN Lipoxygenase 1.906e-22 0.36
AA2BR_RAT Adora2b Adenosine receptor A2b 3.46e-22 0.44
PA_I000X PA Polymerase acidic protein 3.499e-21 0.41
SGMR1_HUMAN SIGMAR1 Sigma non-opioid intracellular receptor 1 7.248e-21 0.64
Q8VH26_CAVPO GPM3 Muscarinic acetylcholine receptor 2.534e-20 0.49
LIPL_HUMAN LPL Lipoprotein lipase 3.801e-20 0.32
EBPL_HUMAN EBPL Emopamil-binding protein-like 1.913e-19 0.31
LAT1_HUMAN SLC7A5 Large neutral amino acids transporter small subunit 1 6.741e-19 0.30
FAAH1_MOUSE Faah Fatty-acid amide hydrolase 1 1.547e-18 0.34
D5FGE8_TRYCR POT1.5 Putative amino acid permease/transporter 2.139e-18 0.29
O61059_LEIME LmGT2 Glucose transporter 6.777e-18 0.51
IBP5_HUMAN IGFBP5 Insulin-like growth factor-binding protein 5 6.99e-18 0.29
ERR3_HUMAN ESRRG Estrogen-related receptor gamma 2.22e-16 0.35
POLG_CXB3N Genome polyprotein 2.22e-16 0.34
S1PR2_HUMAN S1PR2 Sphingosine 1-phosphate receptor 2 7.772e-16 0.48
KDM4E_HUMAN KDM4E Lysine-specific demethylase 4E 8.882e-16 0.44
EGFR_MOUSE Egfr Epidermal growth factor receptor 1.998e-15 0.34
SC6A4_MOUSE Slc6a4 Sodium-dependent serotonin transporter 2.554e-15 0.30
EZRI_HUMAN EZR Ezrin 5.662e-15 0.37
ADRB3_CANLF ADRB3 Beta-3 adrenergic receptor 7.661e-15 0.31
Q8I2J3_PLAF7 M18 aspartyl aminopeptidase 9.104e-15 0.50
LOX1_SOYBN LOX1.1 Seed linoleate 13S-lipoxygenase-1 2.742e-14 0.36
Q3I4V7_CRYNV CAN2 Carbonic anhydrase 4.53e-14 0.43
ADRB1_RAT Adrb1 Beta-1 adrenergic receptor 5.751e-14 0.44
GTR1_HUMAN SLC2A1 Solute carrier family 2, facilitated glucose transporter member 1 7.216e-14 0.51
CBS_HUMAN CBS Cystathionine beta-synthase 1.391e-13 0.37
CAN_CANAL NCE103 Carbonic anhydrase 1.84e-13 0.43
NMDE2_RAT Grin2b Glutamate receptor ionotropic, NMDA 2B 3.557e-13 0.67
Q8I6E4_LEIIN SIR2RP1 NAD-dependent protein deacetylase 3.922e-13 0.29
O97467_PLAFA ht1 Hexose transporter 1 4.258e-13 0.51
NOS1_RAT Nos1 Nitric oxide synthase, brain 5.124e-13 0.36
FDFT_HUMAN FDFT1 Squalene synthase 1.037e-12 0.35
ADA1D_HUMAN ADRA1D Alpha-1D adrenergic receptor 2.198e-12 0.48
P96878_MYCTU Probable transmembrane carbonic anhydrase (Carbonate dehydratase) (Carbonic dehydratase) 3.099e-12 0.43
AOFA_BOVIN MAOA Amine oxidase [flavin-containing] A 4.677e-12 0.40
Q965D5_PLAFA fabI Enoyl-acyl-carrier protein reductase 4.798e-12 0.39
5HT2C_RAT Htr2c 5-hydroxytryptamine receptor 2C 4.912e-12 0.40
FUCO_HUMAN FUCA1 Tissue alpha-L-fucosidase 7.091e-12 0.31
BRS3_HUMAN BRS3 Bombesin receptor subtype-3 1.033e-11 0.36
CBPA1_BOVIN CPA1 Carboxypeptidase A1 1.111e-11 0.33
AMPN_PIG ANPEP Aminopeptidase N 1.359e-11 0.38
B0FL73_CAVPO ADRB1 Beta-1 adrenergic receptor 2.006e-11 0.41
HYEP_MOUSE Ephx1 Epoxide hydrolase 1 3.937e-11 0.36
LOX15_RABIT ALOX15 Arachidonate 15-lipoxygenase 7.709e-11 0.48
Q6RY99_RAT Tetraspanin 1.105e-10 0.29
CHLE_HORSE BCHE Cholinesterase 1.22e-10 0.43
Q2PCB5_DICLA ca Carbonic anhydrase 1.479e-10 0.28
HDAC1_HUMAN HDAC1 Histone deacetylase 1 1.508e-10 0.45
Q49PX0_9POXV N1L N1L 1.642e-10 0.38
NMDE1_HUMAN GRIN2A Glutamate receptor ionotropic, NMDA 2A 1.701e-10 0.38
COMT_PIG COMT Catechol O-methyltransferase 2.433e-10 0.33
1433G_HUMAN YWHAG 14-3-3 protein gamma 3.934e-10 0.36
Q7ZJM1_9HIV1 pol Integrase 4.979e-10 0.42
OXDA_HUMAN DAO D-amino-acid oxidase 5.055e-10 0.40
HCAR2_RAT Hcar2 Hydroxycarboxylic acid receptor 2 5.219e-10 0.34
LEF_BACAN lef Lethal factor 7.358e-10 0.41
SCYD_MAGO7 SDH1 Scytalone dehydratase 1.048e-09 0.39
B2LA1_HUMAN BCL2A1 Bcl-2-related protein A1 1.379e-09 0.33
KDM6B_HUMAN KDM6B Lysine-specific demethylase 6B 1.447e-09 0.31
NMDZ1_RAT Grin1 Glutamate receptor ionotropic, NMDA 1 1.606e-09 0.67
SGMR2_HUMAN TMEM97 Sigma intracellular receptor 2 1.943e-09 0.29
LIPE_MOUSE Lipg Endothelial lipase 2e-09 0.33
S1PR3_HUMAN S1PR3 Sphingosine 1-phosphate receptor 3 3.244e-09 0.48
Q9BEG3_BOVIN 5-lipoxygenase 3.796e-09 0.36
CAH2_HUMAN CA2 Carbonic anhydrase 2 4.965e-09 0.48
S6A11_MOUSE Slc6a11 Sodium- and chloride-dependent GABA transporter 3 5.342e-09 0.38
DRD2_HUMAN DRD2 D(2) dopamine receptor 5.447e-09 0.61
ACM2_HUMAN CHRM2 Muscarinic acetylcholine receptor M2 6.572e-09 0.49
DRD4_HUMAN DRD4 D(4) dopamine receptor 6.894e-09 0.61
MTCA1_MYCTU mtcA1 Beta-carbonic anhydrase 1 7.625e-09 0.43
LKHA4_HUMAN LTA4H Leukotriene A-4 hydrolase 8.201e-09 0.37
COMT_RAT Comt Catechol O-methyltransferase 8.645e-09 0.30
CMA1_HUMAN CMA1 Chymase 8.757e-09 0.32
DOPO_RAT Dbh Dopamine beta-hydroxylase 9.079e-09 0.29
5HT1E_HUMAN HTR1E 5-hydroxytryptamine receptor 1E 9.352e-09 0.36
AK1C4_HUMAN AKR1C4 Aldo-keto reductase family 1 member C4 1.142e-08 0.36
DYN1_HUMAN DNM1 Dynamin-1 1.189e-08 0.31
5HT5A_HUMAN HTR5A 5-hydroxytryptamine receptor 5A 1.255e-08 0.36
BGAL_BOVIN GLB1 Beta-galactosidase 1.892e-08 0.31
ACES_ELEEL ache Acetylcholinesterase 2.102e-08 0.37
SMYD2_HUMAN SMYD2 N-lysine methyltransferase SMYD2 2.297e-08 0.30
CAH12_HUMAN CA12 Carbonic anhydrase 12 2.59e-08 0.48
SPRE_HUMAN SPR Sepiapterin reductase 3.288e-08 0.31
CAH1_HUMAN CA1 Carbonic anhydrase 1 3.614e-08 0.48
Q94F81_MAIZE hda106 HD2 type histone deacetylase HDA106 3.689e-08 0.36
TBB2B_BOVIN TUBB2B Tubulin beta-2B chain 3.75e-08 0.35
SCN5A_HUMAN SCN5A Sodium channel protein type 5 subunit alpha 3.753e-08 0.31
CXCR4_RAT Cxcr4 C-X-C chemokine receptor type 4 4.908e-08 0.38
HYEP_HUMAN EPHX1 Epoxide hydrolase 1 5.627e-08 0.36
ACM1_DROME mAChR-A Muscarinic acetylcholine receptor DM1 6.126e-08 0.31
DOPO_HUMAN DBH Dopamine beta-hydroxylase 7.387e-08 0.29
CAH5A_HUMAN CA5A Carbonic anhydrase 5A, mitochondrial 1.632e-07 0.48
S1PR4_HUMAN S1PR4 Sphingosine 1-phosphate receptor 4 1.821e-07 0.48
EST1_HUMAN CES1 Liver carboxylesterase 1 1.835e-07 0.34
CAH3_HUMAN CA3 Carbonic anhydrase 3 2.244e-07 0.48
NOS2_MOUSE Nos2 Nitric oxide synthase, inducible 2.441e-07 0.32
GRIA4_RAT Gria4 Glutamate receptor 4 2.486e-07 0.40
CAH9_HUMAN CA9 Carbonic anhydrase 9 2.563e-07 0.48
TTHY_HUMAN TTR Transthyretin 2.866e-07 0.36
PAO1_MAIZE MPAO1 Polyamine oxidase 1 2.918e-07 0.40
IBP3_HUMAN IGFBP3 Insulin-like growth factor-binding protein 3 3.239e-07 0.29
LOX5_RAT Alox5 Arachidonate 5-lipoxygenase 3.538e-07 0.39
AOFB_BOVIN MAOB Amine oxidase [flavin-containing] B 3.776e-07 0.37
AK1BA_HUMAN AKR1B10 Aldo-keto reductase family 1 member B10 4.489e-07 0.36
ENPP2_MOUSE Enpp2 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 4.59e-07 0.31
S22A1_HUMAN SLC22A1 Solute carrier family 22 member 1 4.605e-07 0.48
LPAR2_HUMAN LPAR2 Lysophosphatidic acid receptor 2 4.771e-07 0.29
Q6FTL6_CANGA NCE103 Carbonic anhydrase 5.137e-07 0.31
DRD3_HUMAN DRD3 D(3) dopamine receptor 5.656e-07 0.61
SGMR1_CAVPO SIGMAR1 Sigma non-opioid intracellular receptor 1 5.873e-07 0.37
PPBI_MOUSE Iap Intestinal-type alkaline phosphatase 6.561e-07 0.39
CAH3_BOVIN CA3 Carbonic anhydrase 3 7.518e-07 0.29
FAAH1_RAT Faah Fatty-acid amide hydrolase 1 8.623e-07 0.35
CAH14_HUMAN CA14 Carbonic anhydrase 14 8.76e-07 0.39
POLG_DEN2P Genome polyprotein 9.396e-07 0.29
DRD1_HUMAN DRD1 D(1A) dopamine receptor 9.398e-07 0.61
CAH15_MOUSE Ca15 Carbonic anhydrase 15 9.448e-07 0.48
SC6A3_MOUSE Slc6a3 Sodium-dependent dopamine transporter 1.039e-06 0.30
NMDZ1_HUMAN GRIN1 Glutamate receptor ionotropic, NMDA 1 1.195e-06 0.38
LOX15_PIG ALOX15 Arachidonate 15-lipoxygenase 1.198e-06 0.28
CP2D6_HUMAN CYP2D6 Cytochrome P450 2D6 1.38e-06 0.39
PPBN_HUMAN ALPG Alkaline phosphatase, germ cell type 1.447e-06 0.40
Q9K2N0_PSEAI blaVIM-2 Beta-lactamase class B VIM-2 1.657e-06 0.30
GRIA3_RAT Gria3 Glutamate receptor 3 2.414e-06 0.40
CAH5B_HUMAN CA5B Carbonic anhydrase 5B, mitochondrial 2.653e-06 0.48
DRD2_RAT Drd2 D(2) dopamine receptor 2.92e-06 0.44
HDAC8_HUMAN HDAC8 Histone deacetylase 8 3.561e-06 0.38
OXDA_PIG DAO D-amino-acid oxidase 3.791e-06 0.33
HRH1_CAVPO HRH1 Histamine H1 receptor 3.881e-06 0.34
STAT6_HUMAN STAT6 Signal transducer and activator of transcription 6 4.313e-06 0.32
FUCO_RAT Fuca1 Tissue alpha-L-fucosidase 4.596e-06 0.29
CAH7_HUMAN CA7 Carbonic anhydrase 7 4.742e-06 0.48
SGMR1_RAT Sigmar1 Sigma non-opioid intracellular receptor 1 4.784e-06 0.58
AMD_RAT Pam Peptidylglycine alpha-amidating monooxygenase 4.962e-06 0.31
OXDA_MOUSE Dao D-amino-acid oxidase 5.252e-06 0.28
HRH3_CAVPO HRH3 Histamine H3 receptor 6.652e-06 0.34
DRD1_RAT Drd1 D(1A) dopamine receptor 7.698e-06 0.44
FPPS_HUMAN FDPS Farnesyl pyrophosphate synthase 8.882e-06 0.41
SC6A3_RAT Slc6a3 Sodium-dependent dopamine transporter 9.825e-06 0.44

Voxilaprevir

Q0ZMF1_9HEPC NS3 NS3 protease 1.047e-109 0.50
K7XJL6_9HEPC Genome polyprotein 1.458e-105 0.50
A3EZI9_9HEPC NS3 Genome polyprotein 5.93e-08 0.50
A0A0K1CY61_9HEPC Nonstructural protein NS3-4A 2.415e-07 0.31

Isoflavone

ALDH2_HUMAN ALDH2 Aldehyde dehydrogenase, mitochondrial 4.52e-108 0.43
SIAT1_RAT St6gal1 Beta-galactoside alpha-2,6-sialyltransferase 1 2.94e-50 0.34
NQO1_RAT Nqo1 NAD(P)H dehydrogenase [quinone] 1 5.351e-37 0.29
NQO1_HUMAN NQO1 NAD(P)H dehydrogenase [quinone] 1 1.622e-29 0.39
LYSC1_RAT Lyz1 Lysozyme C-1 2.127e-26 0.33
IL2_HUMAN IL2 Interleukin-2 4.412e-24 0.43
RMLD_MYCTU rmlD dTDP-4-dehydrorhamnose reductase 9.719e-24 0.29
SIAT6_RAT St3gal3 CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase 1.605e-23 0.29
CRTN_STAA3 crtN 4,4'-diapophytoene desaturase (4,4'-diaponeurosporene-forming) 2.642e-21 0.34
GLR_RAT Gcgr Glucagon receptor 1.41e-20 0.33
BGLR_RAT Gusb Beta-glucuronidase 1.948e-20 0.33
Q965D7_PLAFA fabZ Beta-hydroxyacyl-ACP dehydratase 3.912e-18 0.38
LOX12_HUMAN ALOX12 Arachidonate 12-lipoxygenase, 12S-type 5.959e-18 0.53
CRTN_STAAW crtN 4,4'-diapophytoene desaturase (4,4'-diaponeurosporene-forming) 8.756e-18 0.34
P89582_9HIV2 pol Integrase 3.442e-15 0.33
TPIS_TRYCR Triosephosphate isomerase, glycosomal 6.772e-15 0.28
CP1B1_HUMAN CYP1B1 Cytochrome P450 1B1 7.727e-14 0.46
PCSK7_HUMAN PCSK7 Proprotein convertase subtilisin/kexin type 7 1.965e-13 0.29
SIAT1_HUMAN ST6GAL1 Beta-galactoside alpha-2,6-sialyltransferase 1 4.531e-12 0.34
AOFA_HUMAN MAOA Amine oxidase [flavin-containing] A 4.749e-12 0.47
GSK3B_HUMAN GSK3B Glycogen synthase kinase-3 beta 6.561e-12 0.42
CRTN_STAAM crtN 4,4'-diapophytoene desaturase (4,4'-diaponeurosporene-forming) 1.435e-11 0.34
AL1B1_HUMAN ALDH1B1 Aldehyde dehydrogenase X, mitochondrial 2.335e-11 0.33
AL1A2_HUMAN ALDH1A2 Retinal dehydrogenase 2 1.441e-10 0.33
STXA_SHIDY stxA Shiga toxin subunit A 4.412e-10 0.36
BKRB1_RABIT BDKRB1 B1 bradykinin receptor 2.33e-09 0.37
TNKS1_HUMAN TNKS Poly [ADP-ribose] polymerase tankyrase-1 2.373e-09 0.32
AOFB_HUMAN MAOB Amine oxidase [flavin-containing] B 5.414e-09 0.56
CBR1_HUMAN CBR1 Carbonyl reductase [NADPH] 1 7.167e-09 0.33
BLAN1_KLEPN blaNDM-1 Metallo-beta-lactamase type 2 1.132e-08 0.53
CALM1_HUMAN CALM1 Calmodulin-1 2.237e-08 0.30
ERCC5_HUMAN ERCC5 DNA repair protein complementing XP-G cells 1.001e-07 0.36
SMAD3_HUMAN SMAD3 Mothers against decapentaplegic homolog 3 1.934e-07 0.29
PTPRS_HUMAN PTPRS Receptor-type tyrosine-protein phosphatase S 5.944e-07 0.33
CP1A1_HUMAN CYP1A1 Cytochrome P450 1A1 7.111e-07 0.31
TP4A3_HUMAN PTP4A3 Protein tyrosine phosphatase type IVA 3 9.433e-07 0.32
FEN1_HUMAN FEN1 Flap endonuclease 1 1.016e-06 0.36
ABCG2_HUMAN ABCG2 Broad substrate specificity ATP-binding cassette transporter ABCG2 1.896e-06 0.45
CAH12_HUMAN CA12 Carbonic anhydrase 12 2.677e-06 0.46
IL5_MOUSE Il5 Interleukin-5 3.059e-06 0.33
KPCG_RAT Prkcg Protein kinase C gamma type 3.207e-06 0.42
AK1C1_HUMAN AKR1C1 Aldo-keto reductase family 1 member C1 3.544e-06 0.31
LOX15_HUMAN ALOX15 Arachidonate 15-lipoxygenase 3.97e-06 0.37

Tenapanor

SL9A3_RAT Slc9a3 Sodium/hydrogen exchanger 3 9.932e-97 0.84
SL9A3_HUMAN SLC9A3 Sodium/hydrogen exchanger 3 9.971e-39 0.79
ARP19_RAT Arpp19 cAMP-regulated phosphoprotein 19 2.158e-24 0.30
F16P1_HUMAN FBP1 Fructose-1,6-bisphosphatase 1 7.772e-16 0.42
5HT7R_HUMAN HTR7 5-hydroxytryptamine receptor 7 2.243e-13 0.38
Q9TSW7_PIG ADRA1A Alpha-1A adrenergic receptor 7.297e-12 0.29
TYTR_TRYBB TPR Trypanothione reductase 8.473e-11 0.30
SC6A4_HUMAN SLC6A4 Sodium-dependent serotonin transporter 1.117e-08 0.36
DHI1_MOUSE Hsd11b1 Corticosteroid 11-beta-dehydrogenase isozyme 1 1.955e-08 0.37
5HT6R_HUMAN HTR6 5-hydroxytryptamine receptor 6 5.272e-08 0.34
SC6A4_RAT Slc6a4 Sodium-dependent serotonin transporter 1.86e-07 0.36
TMPS6_HUMAN TMPRSS6 Transmembrane protease serine 6 1.379e-06 0.31
HYEP_MOUSE Ephx1 Epoxide hydrolase 1 5.036e-06 0.29
MMP15_HUMAN MMP15 Matrix metalloproteinase-15 8.558e-06 0.28

Binimetinib

MP2K1_HUMAN MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 3.121e-91 0.84
MP2K1_MOUSE Map2k1 Dual specificity mitogen-activated protein kinase kinase 1 8.352e-50 0.42
EGFR_HUMAN EGFR Epidermal growth factor receptor 3.22e-14 0.84
VGFR2_HUMAN KDR Vascular endothelial growth factor receptor 2 4.592e-12 0.34
MK06_HUMAN MAPK6 Mitogen-activated protein kinase 6 2.795e-09 0.31
TBA1A_RAT Tuba1a Tubulin alpha-1A chain 2.795e-09 0.31
COQ8A_HUMAN COQ8A Atypical kinase COQ8A, mitochondrial 2.596e-08 0.31
MRCKB_HUMAN CDC42BPB Serine/threonine-protein kinase MRCK beta 6.381e-08 0.31
MRCKG_HUMAN CDC42BPG Serine/threonine-protein kinase MRCK gamma 6.381e-08 0.31
ST32A_HUMAN STK32A Serine/threonine-protein kinase 32A 6.381e-08 0.31
COQ8B_HUMAN COQ8B Atypical kinase COQ8B, mitochondrial 1.41e-07 0.31
SIK3_HUMAN SIK3 Serine/threonine-protein kinase SIK3 1.41e-07 0.31
MP2K2_HUMAN MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 2.097e-07 0.84
HUNK_HUMAN HUNK Hormonally up-regulated neu tumor-associated kinase 2.853e-07 0.31
KPYK_STAAR pyk Pyruvate kinase 1.09e-06 0.30
RIPK4_HUMAN RIPK4 Receptor-interacting serine/threonine-protein kinase 4 1.595e-06 0.31
M3K4_HUMAN MAP3K4 Mitogen-activated protein kinase kinase kinase 4 2.561e-06 0.31
TESK1_HUMAN TESK1 Dual specificity testis-specific protein kinase 1 3.955e-06 0.31
STK35_HUMAN STK35 Serine/threonine-protein kinase 35 8.551e-06 0.31

Deflazacort

ATTY_RAT Tat Tyrosine aminotransferase 9.435e-85 0.32
GCR_RAT Nr3c1 Glucocorticoid receptor 4.432e-52 0.52
Q690N0_BOVIN PGR Progesterone receptor 8.858e-41 0.52
CBG_HUMAN SERPINA6 Corticosteroid-binding globulin 3.919e-33 0.50
GCR_MOUSE Nr3c1 Glucocorticoid receptor 4.608e-32 0.50
GCR_HUMAN NR3C1 Glucocorticoid receptor 1.328e-28 0.53
S22A3_RAT Slc22a3 Solute carrier family 22 member 3 1.523e-18 0.29
FABPL_RAT Fabp1 Fatty acid-binding protein, liver 1.887e-15 0.50
GLNA_HUMAN GLUL Glutamine synthetase 1.887e-15 0.50
SO1A1_RAT Slco1a1 Solute carrier organic anion transporter family member 1A1 8.138e-14 0.30
IL6_HUMAN IL6 Interleukin-6 2.682e-12 0.50
S22A2_RAT Slc22a2 Solute carrier family 22 member 2 1.511e-07 0.29
SHBG_HUMAN SHBG Sex hormone-binding globulin 7.454e-07 0.34
S22A3_HUMAN SLC22A3 Solute carrier family 22 member 3 1.959e-06 0.29
DHI2_HUMAN HSD11B2 Corticosteroid 11-beta-dehydrogenase isozyme 2 2.074e-06 0.30

Propiverine

Q8WMX0_BOVIN Muscarinic receptor M1 2.398e-83 0.38
ACM3_HUMAN CHRM3 Muscarinic acetylcholine receptor M3 5.581e-81 0.64
AMYP_RAT Amy2 Pancreatic alpha-amylase 2.795e-74 0.35
CP2J2_HUMAN CYP2J2 Cytochrome P450 2J2 8.696e-68 0.34
ACM2_HUMAN CHRM2 Muscarinic acetylcholine receptor M2 1.592e-58 0.42
ACM1_HUMAN CHRM1 Muscarinic acetylcholine receptor M1 6.381e-57 0.39
Q8VH26_CAVPO GPM3 Muscarinic acetylcholine receptor 4.178e-49 0.39
GSTT1_RAT Gstt1 Glutathione S-transferase theta-1 1.658e-48 0.39
LPXC_AQUAE lpxC UDP-3-O-acyl-N-acetylglucosamine deacetylase 8.943e-44 0.34
Q8WSF8_APLCA Soluble acetylcholine receptor 3.458e-41 0.35
5HT3A_RAT Htr3a 5-hydroxytryptamine receptor 3A 6.09e-39 0.37
BKRB1_MACFA BDKRB1 B1 bradykinin receptor 6.283e-39 0.34
ACM3_RAT Chrm3 Muscarinic acetylcholine receptor M3 9.122e-39 0.51
ACM5_HUMAN CHRM5 Muscarinic acetylcholine receptor M5 4.407e-38 0.40
UBC12_HUMAN UBE2M NEDD8-conjugating enzyme Ubc12 2.222e-36 0.29
ABHDB_HUMAN ABHD11 Protein ABHD11 2.773e-36 0.31
ACM4_HUMAN CHRM4 Muscarinic acetylcholine receptor M4 4.383e-36 0.42
Q8QGU2_CHICK FKBP12.6 Peptidylprolyl isomerase 2.934e-35 0.32
5HT3B_RAT Htr3b 5-hydroxytryptamine receptor 3B 3.327e-35 0.37
ACHP_LYMST Acetylcholine-binding protein 1.575e-33 0.38
SC6A1_RAT Slc6a1 Sodium- and chloride-dependent GABA transporter 1 8.514e-31 0.32
ACM1_DROME mAChR-A Muscarinic acetylcholine receptor DM1 1.302e-30 0.36
ACM2_RAT Chrm2 Muscarinic acetylcholine receptor M2 2.709e-30 0.51
FKB1A_RAT Fkbp1a Peptidyl-prolyl cis-trans isomerase FKBP1A 2.246e-29 0.31
KITM_HUMAN TK2 Thymidine kinase 2, mitochondrial 8.626e-28 0.31
PA24A_BOVIN PLA2G4A Cytosolic phospholipase A2 9.029e-28 0.32
ACH10_RAT Chrna10 Neuronal acetylcholine receptor subunit alpha-10 2.491e-26 0.34
Q6A2E2_AEDAE ace-1 Acetylcholinesterase 2.258e-25 0.31
MEN1_HUMAN MEN1 Menin 1.426e-24 0.31
Q6TUJ4_PSEAI blaIMP-1 Metallo beta-lactamase 4.119e-22 0.30
SC6A3_RAT Slc6a3 Sodium-dependent dopamine transporter 2.196e-20 0.40
DCNL1_HUMAN DCUN1D1 DCN1-like protein 1 3.682e-20 0.32
HRH1_CAVPO HRH1 Histamine H1 receptor 4.361e-19 0.34
LKHA4_HUMAN LTA4H Leukotriene A-4 hydrolase 2.714e-18 0.33
PA24B_HUMAN PLA2G4B Cytosolic phospholipase A2 beta 2.739e-18 0.31
SC6A5_HUMAN SLC6A5 Sodium- and chloride-dependent glycine transporter 2 6.976e-18 0.35
ACES_MOUSE Ache Acetylcholinesterase 2.003e-17 0.33
5HT1F_HUMAN HTR1F 5-hydroxytryptamine receptor 1F 3.02e-17 0.30
ACM4_RAT Chrm4 Muscarinic acetylcholine receptor M4 5.223e-17 0.51
HRH2_HUMAN HRH2 Histamine H2 receptor 1.11e-16 0.36
LUXN_VIBHA luxN Autoinducer 1 sensor kinase/phosphatase LuxN 1.11e-16 0.32
NPY2R_HUMAN NPY2R Neuropeptide Y receptor type 2 1.11e-16 0.37
SC6A4_MOUSE Slc6a4 Sodium-dependent serotonin transporter 1.11e-16 0.32
ACM1_RAT Chrm1 Muscarinic acetylcholine receptor M1 2.22e-16 0.51
S6A11_HUMAN SLC6A11 Sodium- and chloride-dependent GABA transporter 3 2.22e-16 0.31
HRH3_CAVPO HRH3 Histamine H3 receptor 3.331e-16 0.35
ANM6_HUMAN PRMT6 Protein arginine N-methyltransferase 6 5.551e-16 0.40
HCN1_HUMAN HCN1 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 1.11e-15 0.29
CAC1G_HUMAN CACNA1G Voltage-dependent T-type calcium channel subunit alpha-1G 1.665e-15 0.37
Q8II92_PLAF7 Deoxyuridine 5'-triphosphate nucleotidohydrolase 1.998e-15 0.31
HCN4_HUMAN HCN4 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 8.882e-15 0.29
KITH_HHV1 TK Thymidine kinase 1.776e-14 0.31
SC5A7_HUMAN SLC5A7 High affinity choline transporter 1 6.04e-14 0.32
GNAI3_HUMAN GNAI3 Guanine nucleotide-binding protein G(i) subunit alpha 1.463e-13 0.33
ACM5_RAT Chrm5 Muscarinic acetylcholine receptor M5 1.997e-13 0.33
CARM1_HUMAN CARM1 Histone-arginine methyltransferase CARM1 2.613e-13 0.40
SC6A3_MACFA SLC6A3 Sodium-dependent dopamine transporter 3.505e-13 0.28
GNAI1_HUMAN GNAI1 Guanine nucleotide-binding protein G(i) subunit alpha-1 4.431e-13 0.32
DNK_DROME dnk Deoxynucleoside kinase 1.031e-12 0.29
DRD2_MOUSE Drd2 D(2) dopamine receptor 3.675e-12 0.31
LPAR5_HUMAN LPAR5 Lysophosphatidic acid receptor 5 3.881e-12 0.30
CEL2A_PIG CELA2A Chymotrypsin-like elastase family member 2A 5.875e-12 0.30
LYPA2_HUMAN LYPLA2 Acyl-protein thioesterase 2 1.437e-11 0.28
ABHD6_HUMAN ABHD6 Monoacylglycerol lipase ABHD6 2.297e-11 0.31
CTRB1_HUMAN CTRB1 Chymotrypsinogen B 3.097e-11 0.30
Q6Q253_PIG 5-HT4R 5-hydroxytryptamine receptor 4 protein 3.989e-11 0.30
S1PR5_HUMAN S1PR5 Sphingosine 1-phosphate receptor 5 5.089e-11 0.36
Q9WTR4_RAT Slc6a2 Transporter 5.641e-11 0.32
Q98UH1_DANRE oprm1 Mu opioid receptor-like OR2 7.655e-11 0.29
SC6A1_HUMAN SLC6A1 Sodium- and chloride-dependent GABA transporter 1 1.131e-10 0.39
LYPA1_HUMAN LYPLA1 Acyl-protein thioesterase 1 1.577e-10 0.28
FKB1A_HUMAN FKBP1A Peptidyl-prolyl cis-trans isomerase FKBP1A 2.408e-10 0.32
SGMR1_MOUSE Sigmar1 Sigma non-opioid intracellular receptor 1 3.928e-10 0.31
NMD3A_RAT Grin3a Glutamate receptor ionotropic, NMDA 3A 6.32e-10 0.29
ACES_HUMAN ACHE Acetylcholinesterase 1.942e-09 0.35
SC6A4_RAT Slc6a4 Sodium-dependent serotonin transporter 2.755e-09 0.35
KITH_HUMAN TK1 Thymidine kinase, cytosolic 9.503e-09 0.30
HRH1_HUMAN HRH1 Histamine H1 receptor 1.663e-08 0.42
SGMR2_RAT Tmem97 Sigma intracellular receptor 2 2.138e-08 0.29
S6A13_MOUSE Slc6a13 Sodium- and chloride-dependent GABA transporter 2 2.301e-08 0.31
SGMR1_HUMAN SIGMAR1 Sigma non-opioid intracellular receptor 1 4.665e-08 0.36
S6A11_MOUSE Slc6a11 Sodium- and chloride-dependent GABA transporter 3 1.264e-07 0.31
CHLE_HUMAN BCHE Cholinesterase 1.561e-07 0.33
SC6A3_MOUSE Slc6a3 Sodium-dependent dopamine transporter 3.025e-07 0.32
BKRB1_RAT Bdkrb1 B1 bradykinin receptor 3.839e-07 0.34
SGMR1_CAVPO SIGMAR1 Sigma non-opioid intracellular receptor 1 4.323e-07 0.35
ACM2_MOUSE Chrm2 Muscarinic acetylcholine receptor M2 4.404e-07 0.33
VMAT2_RAT Slc18a2 Synaptic vesicular amine transporter 4.551e-07 0.30
CATG_HUMAN CTSG Cathepsin G 4.571e-07 0.30
CXCR5_HUMAN CXCR5 C-X-C chemokine receptor type 5 8.415e-07 0.29
PA2GD_HUMAN PLA2G2D Group IID secretory phospholipase A2 9.396e-07 0.29
Q6P1E0_MOUSE Syk Tyrosine-protein kinase 1.34e-06 0.30
NORA_STAAU norA Quinolone resistance protein NorA 1.374e-06 0.33
5HT4R_CAVPO HTR4 5-hydroxytryptamine receptor 4 1.601e-06 0.30
DGLA_HUMAN DAGLA Sn1-specific diacylglycerol lipase alpha 1.782e-06 0.31
HYES_RAT Ephx2 Bifunctional epoxide hydrolase 2 1.948e-06 0.31
GLRA1_RAT Glra1 Glycine receptor subunit alpha-1 2.049e-06 0.29
CP2D6_HUMAN CYP2D6 Cytochrome P450 2D6 2.753e-06 0.45
LMBL1_HUMAN L3MBTL1 Lethal(3)malignant brain tumor-like protein 1 5.54e-06 0.30
NAMPT_HUMAN NAMPT Nicotinamide phosphoribosyltransferase 6.11e-06 0.33
SC6A1_MOUSE Slc6a1 Sodium- and chloride-dependent GABA transporter 1 6.478e-06 0.29

Sultamicillin

BLAC_BACLI penP Beta-lactamase 5.132e-80 0.36
AMPC_CITFR ampC Beta-lactamase 3.766e-66 0.36
A1E3K9_ECOLX blaSCO-1 Beta-lactamase 1.255e-56 0.39
A8RR46_BACCS bcl1 Beta-lactamase 1.255e-56 0.39
D2SSQ3_PSEAI Beta-lactamase 1.255e-56 0.39
Q3SAW3_PSEAI bla(BEL1) Beta-lactamase 1.255e-56 0.39
D5HSX5_9GAMM blaPER-6 Beta-lactamase 1.721e-49 0.39
Q0VTR6_ACIPI adc-14 Beta-lactamase 1.721e-49 0.39
Q0VTR8_ACIPI adc-16 Beta-lactamase 1.721e-49 0.39
Q7X575_ECOLX SHV-11 Beta-lactamase 1.721e-49 0.39
Q53729_STAAU PBP2 Penicillin-binding protein 2 1.302e-45 0.36
D1MIX9_PSEAI blaGES-13 Beta-lactamase 1.253e-43 0.39
Q3S5C3_SALNE sugE Efflux transporter 7.397e-41 0.34
Q48435_KLEPN bla LAT-2 Beta-lactamase 7.397e-41 0.34
A0ZX81_KLEPN blaSHV-72 Beta-lactamase 5.239e-40 0.32
A4KCT8_9ENTR BlaGIL-1 Beta-lactamase 5.239e-40 0.32
AMPC_MORMO ampC Beta-lactamase 5.239e-40 0.32
B8R6A5_9BURK penB1 Beta-lactamase 5.239e-40 0.32
BLKPC_KLEPN bla Carbapenem-hydrolyzing beta-lactamase KPC 5.239e-40 0.32
BLO1_ECOLX bla Beta-lactamase OXA-1 5.239e-40 0.32
Q2XPY6_SALET blaCTX-M-53 Beta-lactamase 5.239e-40 0.32
Q50H31_BRAPL oxa-63 Class D beta-lactamase 5.239e-40 0.32
Q670S6_PSELU Beta-lactamase 5.239e-40 0.32
Q6GWS8_ECOLX blaTEM-125 Beta-lactamase 5.239e-40 0.32
Q6JP75_SERFO Beta-lactamase 5.239e-40 0.32
Q9EXV5_ECOLX blaUOE-1 Beta-lactamase 5.239e-40 0.32
A2RP81_CITFR blaPER-2 Beta-lactamase 5.609e-34 0.45
S15A2_HUMAN SLC15A2 Solute carrier family 15 member 2 1.336e-28 0.35
A4ZYU9_ECOLX blaACC-4 Beta-lactamase 7.052e-28 0.34
BLAB_BACCE Metallo-beta-lactamase type 2 1.922e-26 0.30
BLA1_KLEPN bla Beta-lactamase SHV-1 9.886e-26 0.32
CATL1_RAT Ctsl Cathepsin L1 4.749e-24 0.31
XIAP_HUMAN XIAP E3 ubiquitin-protein ligase XIAP 1.326e-23 0.34
AMPC_ENTCL ampC Beta-lactamase 1.704e-20 0.39
CEL2A_PIG CELA2A Chymotrypsin-like elastase family member 2A 1.692e-19 0.34
Q82134_9DELA prt Protease 1.11e-16 0.33
BLA1_ECOLX bla Beta-lactamase SHV-1 3.109e-15 0.39
S15A1_HUMAN SLC15A1 Solute carrier family 15 member 1 7.772e-15 0.28
Q46991_ENTCL imiA Beta-lactamase 1.743e-14 0.32
BLAC_STAAU blaZ Beta-lactamase 6.14e-14 0.39
AMPC_PSEAE ampC Beta-lactamase 4.025e-12 0.35
BIRC8_HUMAN BIRC8 Baculoviral IAP repeat-containing protein 8 1.437e-11 0.28
AMPC_ECOLI ampC Beta-lactamase 2.464e-11 0.35
S15A2_RAT Slc15a2 Solute carrier family 15 member 2 1.819e-10 0.35
BIRC3_HUMAN BIRC3 Baculoviral IAP repeat-containing protein 3 1.969e-08 0.28
BLAT_ECOLX bla; blaT-3; blaT-4; blaT-5; blaT-6 Beta-lactamase TEM 3.099e-08 0.39
ELNE_HUMAN ELANE Neutrophil elastase 7.95e-08 0.48
BIRC2_HUMAN BIRC2 Baculoviral IAP repeat-containing protein 2 1.471e-07 0.29
Q6W9J1_ENTCL blaTEM-1 Beta-lactamase 7.038e-07 0.32
Q82323_9DELA Protease 1.847e-06 0.31
S22A6_HUMAN SLC22A6 Solute carrier family 22 member 6 9.277e-06 0.35

Selinexor

XPO1_HUMAN XPO1 Exportin-1 1.913e-73 0.44
TRPC1_HUMAN TRPC1 Short transient receptor potential channel 1 1.698e-18 0.29

Landiolol

ADRB1_HUMAN ADRB1 Beta-1 adrenergic receptor 7.248e-72 0.58
ADRB3_HUMAN ADRB3 Beta-3 adrenergic receptor 1.648e-57 0.43
ADRB1_RAT Adrb1 Beta-1 adrenergic receptor 6.866e-51 0.44
B0FL73_CAVPO ADRB1 Beta-1 adrenergic receptor 3.115e-46 0.46
ADRB2_HUMAN ADRB2 Beta-2 adrenergic receptor 3.237e-36 0.58
MGLL_RAT Mgll Monoglyceride lipase 2.864e-30 0.33
ADRB2_CAVPO Adrb2 Beta-2 adrenergic receptor 1.324e-17 0.41
NMDE2_RAT Grin2b Glutamate receptor ionotropic, NMDA 2B 1.11e-16 0.37
GP174_HUMAN GPR174 Probable G-protein coupled receptor 174 2.368e-13 0.29
NMDZ1_RAT Grin1 Glutamate receptor ionotropic, NMDA 1 3.056e-13 0.37
MDR1_HUMAN ABCB1 ATP-dependent translocase ABCB1 1.545e-10 0.36
P2Y10_HUMAN P2RY10 Putative P2Y purinoceptor 10 5.521e-10 0.29
ADRB2_CANLF ADRB2 Beta-2 adrenergic receptor 3.224e-07 0.32
PCNA_HUMAN PCNA Proliferating cell nuclear antigen 3.253e-06 0.32
LPXC_PSEAE lpxC UDP-3-O-acyl-N-acetylglucosamine deacetylase 5.849e-06 0.32

Doravirine

Q9WJQ2_9HIV1 reverse transcriptase Reverse transcriptase protein 1.556e-71 0.52
Q9WKE8_9HIV1 reverse transcriptase Reverse transcriptase 2.349e-36 0.59
NPBW1_HUMAN NPBWR1 Neuropeptides B/W receptor type 1 8.141e-07 0.32

Mannitol_busulfan

ALF_TRYBB ALD Fructose-bisphosphate aldolase, glycosomal 5.567e-69 0.44
ALDOA_RABIT ALDOA Fructose-bisphosphate aldolase A 1.352e-50 0.44
Q9GRG6_9TRYP 6pgl 6-phosphogluconolactonase 1.968e-44 0.35
G6PI_RABIT GPI Glucose-6-phosphate isomerase 1.443e-37 0.30
Q38DI7_TRYB2 6-phosphogluconate dehydrogenase, decarboxylating 1.242e-13 0.30
DCOR_RAT Odc1 Ornithine decarboxylase 9.412e-08 0.30

Indium_In-111_pentetreotide

SSR5_RAT Sstr5 Somatostatin receptor type 5 3.626e-68 0.39
SSR2_HUMAN SSTR2 Somatostatin receptor type 2 3.452e-25 0.39
SSR4_HUMAN SSTR4 Somatostatin receptor type 4 3.36e-24 0.39
SSR2_MOUSE Sstr2 Somatostatin receptor type 2 2.792e-20 0.39
UR2R_RAT Uts2r Urotensin-2 receptor 6.671e-18 0.34
SSR3_HUMAN SSTR3 Somatostatin receptor type 3 6.994e-14 0.36
SSR5_HUMAN SSTR5 Somatostatin receptor type 5 2.317e-13 0.39
SSR1_HUMAN SSTR1 Somatostatin receptor type 1 2.695e-11 0.35

Gepotidacin

GYRB_MYCTU gyrB DNA gyrase subunit B 2.019e-63 0.40
GYRA_MYCTU gyrA DNA gyrase subunit A 3.061e-59 0.40
PARE_STAAU parE DNA topoisomerase 4 subunit B 4.604e-23 0.48
FKB1B_HUMAN FKBP1B Peptidyl-prolyl cis-trans isomerase FKBP1B 1.776e-15 0.29
PARC_STAAU parC DNA topoisomerase 4 subunit A 5.44e-15 0.48
GYRA_STAAU gyrA DNA gyrase subunit A 2.13e-12 0.48
GYRB_STAAU gyrB DNA gyrase subunit B 1.023e-07 0.48

Benfotiamine

THIT_LACLM thiT Thiamine transporter ThiT 4.398e-63 0.34
TKT_HUMAN TKT Transketolase 1.253e-53 0.63
DXS_DEIRA dxs 1-deoxy-D-xylulose-5-phosphate synthase 1.651e-42 0.34
DXS_MYCTU dxs 1-deoxy-D-xylulose-5-phosphate synthase 2.54e-27 0.34
P2RX1_RAT P2rx1 P2X purinoceptor 1 1.321e-10 0.31
P2RX1_HUMAN P2RX1 P2X purinoceptor 1 1.96e-06 0.31

Bictegravir

GLYCP_NIPAV G Glycoprotein G 5.374e-63 0.34
ACEA_MYCTU icl Isocitrate lyase 5.329e-15 0.28
DPOL_HHV11 DNA polymerase catalytic subunit 4.607e-13 0.28
DPOL_VZVD DNA polymerase catalytic subunit 4.607e-13 0.28

Defactinib

LRRK2_HUMAN LRRK2 Leucine-rich repeat serine/threonine-protein kinase 2 1.062e-57 0.52
FAK1_HUMAN PTK2 Focal adhesion kinase 1 8.229e-52 0.55
STAT6_HUMAN STAT6 Signal transducer and activator of transcription 6 7.033e-40 0.35
AURKA_MOUSE Aurka Aurora kinase A 6.55e-39 0.30
TPOR_HUMAN MPL Thrombopoietin receptor 1.957e-38 0.35
AURKB_MOUSE Aurkb Aurora kinase B 2.569e-38 0.30
FAK2_HUMAN PTK2B Protein-tyrosine kinase 2-beta 2.357e-33 0.55
TF7L2_HUMAN TCF7L2 Transcription factor 7-like 2 3.033e-33 0.34
CTNB1_HUMAN CTNNB1 Catenin beta-1 1.167e-30 0.34
SHH_MOUSE Shh Sonic hedgehog protein 5.813e-30 0.36
CDK1_HUMAN CDK1 Cyclin-dependent kinase 1 6.382e-26 0.52
HGFL_HUMAN MST1 Hepatocyte growth factor-like protein 6.654e-21 0.33
BRAF_HUMAN BRAF Serine/threonine-protein kinase B-raf 1.9e-20 0.36
CDK2_HUMAN CDK2 Cyclin-dependent kinase 2 5.479e-17 0.52
AURKA_HUMAN AURKA Aurora kinase A 1.443e-15 0.52
MATK_HUMAN MATK Megakaryocyte-associated tyrosine-protein kinase 3.197e-14 0.52
TRPV1_RAT Trpv1 Transient receptor potential cation channel subfamily V member 1 1.495e-13 0.34
LGUL_HUMAN GLO1 Lactoylglutathione lyase 1.922e-13 0.34
PMYT1_HUMAN PKMYT1 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase 4.532e-12 0.34
VGFR3_HUMAN FLT4 Vascular endothelial growth factor receptor 3 5.497e-12 0.52
VGFR2_HUMAN KDR Vascular endothelial growth factor receptor 2 3.836e-11 0.52
BMX_HUMAN BMX Cytoplasmic tyrosine-protein kinase BMX 1.823e-10 0.32
ALK_HUMAN ALK ALK tyrosine kinase receptor 6.625e-10 0.52
TSSK1_HUMAN TSSK1B Testis-specific serine/threonine-protein kinase 1 1.433e-09 0.52
SCN9A_HUMAN SCN9A Sodium channel protein type 9 subunit alpha 1.767e-09 0.36
BLK_HUMAN BLK Tyrosine-protein kinase Blk 2.031e-08 0.52
TRPV1_HUMAN TRPV1 Transient receptor potential cation channel subfamily V member 1 2.558e-08 0.34
TSSK2_HUMAN TSSK2 Testis-specific serine/threonine-protein kinase 2 1.306e-07 0.33
WEE2_HUMAN WEE2 Wee1-like protein kinase 2 1.332e-07 0.33
VGFR1_HUMAN FLT1 Vascular endothelial growth factor receptor 1 1.601e-07 0.52
MP2K2_HUMAN MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 2.292e-07 0.52
MAT1_HUMAN MNAT1 CDK-activating kinase assembly factor MAT1 2.56e-07 0.35
GRK5_HUMAN GRK5 G protein-coupled receptor kinase 5 4.135e-07 0.52
AURKB_HUMAN AURKB Aurora kinase B 4.733e-07 0.52
MK09_HUMAN MAPK9 Mitogen-activated protein kinase 9 5.362e-07 0.52
MARK4_HUMAN MARK4 MAP/microtubule affinity-regulating kinase 4 6.347e-07 0.52
MK12_HUMAN MAPK12 Mitogen-activated protein kinase 12 1.284e-06 0.52
ROS1_HUMAN ROS1 Proto-oncogene tyrosine-protein kinase ROS 1.631e-06 0.52
NTRK2_HUMAN NTRK2 BDNF/NT-3 growth factors receptor 1.685e-06 0.52
LTK_HUMAN LTK Leukocyte tyrosine kinase receptor 1.957e-06 0.52
CSK21_HUMAN CSNK2A1 Casein kinase II subunit alpha 1.979e-06 0.52
CDK7_HUMAN CDK7 Cyclin-dependent kinase 7 4.001e-06 0.52
PGFRA_HUMAN PDGFRA Platelet-derived growth factor receptor alpha 4.393e-06 0.33
DAPK3_HUMAN DAPK3 Death-associated protein kinase 3 4.674e-06 0.52
UFO_HUMAN AXL Tyrosine-protein kinase receptor UFO 5.079e-06 0.52
BRSK1_HUMAN BRSK1 Serine/threonine-protein kinase BRSK1 5.363e-06 0.52
NEMO_HUMAN IKBKG NF-kappa-B essential modulator 5.45e-06 0.29
SIK2_HUMAN SIK2 Serine/threonine-protein kinase SIK2 5.991e-06 0.52
AAPK1_HUMAN PRKAA1 5'-AMP-activated protein kinase catalytic subunit alpha-1 6.611e-06 0.52
KCC2D_HUMAN CAMK2D Calcium/calmodulin-dependent protein kinase type II subunit delta 6.721e-06 0.52
M3K10_HUMAN MAP3K10 Mitogen-activated protein kinase kinase kinase 10 7.173e-06 0.52
HIPK2_HUMAN HIPK2 Homeodomain-interacting protein kinase 2 7.203e-06 0.52
KCC2G_HUMAN CAMK2G Calcium/calmodulin-dependent protein kinase type II subunit gamma 7.218e-06 0.52
RON_HUMAN MST1R Macrophage-stimulating protein receptor 7.413e-06 0.52
JAK3_HUMAN JAK3 Tyrosine-protein kinase JAK3 7.751e-06 0.52
PAK4_HUMAN PAK4 Serine/threonine-protein kinase PAK 4 9.091e-06 0.52

Valbenazine

VMAT2_MOUSE Slc18a2 Synaptic vesicular amine transporter 1.098e-57 0.67
VMAT2_RAT Slc18a2 Synaptic vesicular amine transporter 1.108e-57 0.67
VMAT2_HUMAN SLC18A2 Synaptic vesicular amine transporter 7.247e-51 0.67
DRD1_HUMAN DRD1 D(1A) dopamine receptor 3.367e-40 0.43
NMDE4_RAT Grin2d Glutamate receptor ionotropic, NMDA 2D 1.142e-34 0.35
NMDE3_RAT Grin2c Glutamate receptor ionotropic, NMDA 2C 1.978e-32 0.35
VMAT2_BOVIN SLC18A2 Synaptic vesicular amine transporter 6.618e-27 0.54
HCN2_MOUSE Hcn2 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 3.809e-18 0.29
RBBP9_HUMAN RBBP9 Serine hydrolase RBBP9 7.64e-18 0.49
NMDZ1_RAT Grin1 Glutamate receptor ionotropic, NMDA 1 2.22e-16 0.35
TF_HUMAN F3 Tissue factor 2.22e-16 0.42
MTR1B_HUMAN MTNR1B Melatonin receptor type 1B 1.124e-13 0.39
HCN1_MOUSE Hcn1 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 3.285e-13 0.29
DPP4_HUMAN DPP4 Dipeptidyl peptidase 4 1.465e-11 0.52
KCNN1_HUMAN KCNN1 Small conductance calcium-activated potassium channel protein 1 1.019e-10 0.34
DRD5_HUMAN DRD5 D(1B) dopamine receptor 1.314e-10 0.41
CAH14_HUMAN CA14 Carbonic anhydrase 14 1.93e-10 0.33
KCNN2_HUMAN KCNN2 Small conductance calcium-activated potassium channel protein 2 5.378e-09 0.34
OX2R_HUMAN HCRTR2 Orexin receptor type 2 1.847e-08 0.35
OX1R_HUMAN HCRTR1 Orexin receptor type 1 8.888e-08 0.35
FDFT_HUMAN FDFT1 Squalene synthase 9.567e-08 0.30
KCNN3_HUMAN KCNN3 Small conductance calcium-activated potassium channel protein 3 1.981e-06 0.34
O97467_PLAFA ht1 Hexose transporter 1 4.987e-06 0.49
NMDE2_RAT Grin2b Glutamate receptor ionotropic, NMDA 2B 4.988e-06 0.34
O61059_LEIME LmGT2 Glucose transporter 5.497e-06 0.49
DRD2_HUMAN DRD2 D(2) dopamine receptor 8.066e-06 0.43

Delafloxacin

Q47245_ECOLX gyrA DNA gyrase subunit A 5.101e-55 0.41
C3SLN2_ECOLX gyrB DNA gyrase subunit B 1.183e-47 0.41
VATB2_HUMAN ATP6V1B2 V-type proton ATPase subunit B, brain isoform 2.649e-45 0.36
ACEA_MYCTU icl Isocitrate lyase 1.21e-34 0.36
TOP2A_HUMAN TOP2A DNA topoisomerase 2-alpha 3.418e-21 0.37
DPO1_THEAQ polA DNA polymerase I, thermostable 1.351e-17 0.35
PARC_STAAU parC DNA topoisomerase 4 subunit A 5.551e-16 0.42
AADAT_RAT Aadat Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial 1.822e-10 0.38
DPO3_BACSU polC DNA polymerase III PolC-type 7.282e-09 0.34
GYRA_MYCTU gyrA DNA gyrase subunit A 4.671e-08 0.42
AADAT_HUMAN AADAT Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial 3.137e-07 0.38
GYRA_STAAU gyrA DNA gyrase subunit A 3.205e-07 0.42
GYRA_ECOLI gyrA DNA gyrase subunit A 8.33e-06 0.42

P-nitrobiphenyl

PLPL6_MOUSE Pnpla6 Neuropathy target esterase 7.832e-54 0.44
ABHD6_MOUSE Abhd6 Monoacylglycerol lipase ABHD6 5.066e-48 0.44
H9B8T9_CAPHI CTSB Cathepsin B 3.162e-47 0.51
C11B1_RAT Cyp11b1 Cytochrome P450 11B1, mitochondrial 1.821e-45 0.37
MGLL_MOUSE Mgll Monoglyceride lipase 1.385e-43 0.44
NOS3_MOUSE Nos3 Nitric oxide synthase, endothelial 6.005e-43 0.34
UBE2B_HUMAN UBE2B Ubiquitin-conjugating enzyme E2 B 1.356e-39 0.31
COLA_CLOPE colA Collagenase ColA 1.265e-36 0.34
TNF10_HUMAN TNFSF10 Tumor necrosis factor ligand superfamily member 10 1.476e-29 0.37
MYOC_HUMAN MYOC Myocilin 3.477e-29 0.36
PDE4B_RAT Pde4b cAMP-specific 3',5'-cyclic phosphodiesterase 4B 6.759e-29 0.37
S27A2_HUMAN SLC27A2 Very long-chain acyl-CoA synthetase 5.245e-27 0.33
A0A060INS8_CAPHI CTSH Cathepsin H 1.364e-26 0.51
A4HSF7_LEIIN TRYR Trypanothione reductase 1.792e-26 0.33
TRXR2_PLAF7 trxr2 Thioredoxin reductase 2 2.396e-26 0.38
FAAH1_MOUSE Faah Fatty-acid amide hydrolase 1 6.795e-26 0.44
ACRO_PIG ACR Acrosin 1.146e-24 0.35
KCMA1_HUMAN KCNMA1 Calcium-activated potassium channel subunit alpha-1 4.062e-23 0.41
FAS_RAT Fasn Fatty acid synthase 6.402e-21 0.41
TGM2_CAVCU TGM2 Protein-glutamine gamma-glutamyltransferase 2 4.22e-20 0.32
ACHA5_HUMAN CHRNA5 Neuronal acetylcholine receptor subunit alpha-5 1.019e-19 0.42
GGPPS_YEAST BTS1 Geranylgeranyl pyrophosphate synthase 1.335e-19 0.31
STXA_SHIDY stxA Shiga toxin subunit A 1.416e-19 0.38
ABCG2_HUMAN ABCG2 Broad substrate specificity ATP-binding cassette transporter ABCG2 2.741e-19 0.45
TRPM8_RAT Trpm8 Transient receptor potential cation channel subfamily M member 8 2.86e-19 0.40
KMO_RAT Kmo Kynurenine 3-monooxygenase 5.802e-19 0.38
Q01HZ7_ORYSA OSIGBa0132E09-OSIGBa0108L24.11 Glutamine synthetase 6.741e-19 0.30
Q8ST54_TRYCR HK Phosphotransferase 8.915e-19 0.31
GBRA3_RAT Gabra3 Gamma-aminobutyric acid receptor subunit alpha-3 1.698e-18 0.33
LAT1_HUMAN SLC7A5 Large neutral amino acids transporter small subunit 1 2.898e-18 0.29
EST1_RABIT Liver carboxylesterase 1 3.427e-18 0.59
TYSY_PNECA THYA Thymidylate synthase 4.879e-18 0.29
PHLP2_HUMAN PHLPP2 PH domain leucine-rich repeat-containing protein phosphatase 2 6.263e-18 0.38
PVDQ_PSEAE pvdQ Acyl-homoserine lactone acylase PvdQ 7.063e-18 0.41
MGLL_HUMAN MGLL Monoglyceride lipase 7.267e-18 0.37
NORA_STAAU norA Quinolone resistance protein NorA 1.599e-17 0.49
QCR7_HUMAN UQCRB Cytochrome b-c1 complex subunit 7 5.295e-17 0.32
SYUA_HUMAN SNCA Alpha-synuclein 3.331e-16 0.38
I3LTK9_PIG CEL Carboxylic ester hydrolase 9.992e-16 0.40
LIPP_PIG PNLIP Pancreatic triacylglycerol lipase 1.11e-15 0.32
DDX3X_HUMAN DDX3X ATP-dependent RNA helicase DDX3X 1.443e-15 0.30
MBD2_HUMAN MBD2 Methyl-CpG-binding domain protein 2 1.665e-15 0.42
MYC_HUMAN MYC Myc proto-oncogene protein 2.998e-15 0.37
A0A0C7ACN7_PSEAI pqsD 3-oxoacyl-ACP synthase 3.553e-15 0.34
HAOX1_MOUSE Hao1 Hydroxyacid oxidase 1 4.774e-15 0.37
SKN1_CAEEL skn-1 Protein skinhead-1 8.216e-15 0.46
Q8IL32_PLAF7 Heat shock protein 90, putative 1.743e-14 0.47
VE1_HPV11 E1 Replication protein E1 1.921e-14 0.36
AHR_MOUSE Ahr Aryl hydrocarbon receptor 3.153e-14 0.31
TLR9_HUMAN TLR9 Toll-like receptor 9 3.286e-14 0.59
TAU_HUMAN MAPT Microtubule-associated protein tau 3.464e-14 0.38
Q6UCJ9_TOXGO ENR Enoyl-acyl carrier reductase 5.407e-14 0.33
HIS1_MYCTU hisG ATP phosphoribosyltransferase 1.174e-13 0.30
PTR1_LEIMA PTR1 Pteridine reductase 1 1.7e-13 0.35
Q8MTZ4_9TRYP PPase1 Vacuolar-type proton translocating pyrophosphatase 1 3.885e-13 0.30
HPPD_RAT Hpd 4-hydroxyphenylpyruvate dioxygenase 5.338e-13 0.28
MMP8_HUMAN MMP8 Neutrophil collagenase 5.795e-13 0.35
AK1C2_HUMAN AKR1C2 Aldo-keto reductase family 1 member C2 6.56e-13 0.44
ODP2_MYCTU dlaT Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex 9.862e-13 0.44
KMO_MOUSE Kmo Kynurenine 3-monooxygenase 1.191e-12 0.31
MMP16_HUMAN MMP16 Matrix metalloproteinase-16 1.588e-12 0.32
I23O2_HUMAN IDO2 Indoleamine 2,3-dioxygenase 2 2.492e-12 0.33
PNMT_BOVIN PNMT Phenylethanolamine N-methyltransferase 3.723e-12 0.33
BXE_CLOBO botE Botulinum neurotoxin type E 4.628e-12 0.29
PPBT_BOVIN ALPL Alkaline phosphatase, tissue-nonspecific isozyme 5.579e-12 0.33
CP19A_HUMAN CYP19A1 Aromatase 6.368e-12 0.49
PPOC_ARATH PPOX1 Protoporphyrinogen oxidase 1, chloroplastic 1.231e-11 0.34
MEP2_YEAST MEP2 Ammonium transporter MEP2 1.29e-11 0.34
P2RX4_HUMAN P2RX4 P2X purinoceptor 4 1.382e-11 0.39
PTPRC_HUMAN PTPRC Receptor-type tyrosine-protein phosphatase C 1.678e-11 0.44
KAT2B_HUMAN KAT2B Histone acetyltransferase KAT2B 2.134e-11 0.37
EST2_HUMAN CES2 Cocaine esterase 3.077e-11 0.59
KCNJ1_HUMAN KCNJ1 ATP-sensitive inward rectifier potassium channel 1 3.11e-11 0.38
C4YTQ8_CANAW ATP-dependent molecular chaperone HSP82 3.513e-11 0.46
CASP4_HUMAN CASP4 Caspase-4 4.132e-11 0.36
CAH12_HUMAN CA12 Carbonic anhydrase 12 5.434e-11 0.57
ERCC5_HUMAN ERCC5 DNA repair protein complementing XP-G cells 5.455e-11 0.36
MITF_HUMAN MITF Microphthalmia-associated transcription factor 1.109e-10 0.40
SCAF_HCMVA UL80 Capsid scaffolding protein 1.202e-10 0.46
FA5_HUMAN F5 Coagulation factor V 1.336e-10 0.28
GBRA5_RAT Gabra5 Gamma-aminobutyric acid receptor subunit alpha-5 1.503e-10 0.33
TLR4_MOUSE Tlr4 Toll-like receptor 4 1.626e-10 0.35
GBRA1_RAT Gabra1 Gamma-aminobutyric acid receptor subunit alpha-1 1.94e-10 0.33
GBRB3_RAT Gabrb3 Gamma-aminobutyric acid receptor subunit beta-3 2.108e-10 0.33
AK1C3_HUMAN AKR1C3 Aldo-keto reductase family 1 member C3 2.247e-10 0.44
CAH14_HUMAN CA14 Carbonic anhydrase 14 2.911e-10 0.57
GBRB2_RAT Gabrb2 Gamma-aminobutyric acid receptor subunit beta-2 2.995e-10 0.33
AOFB_HUMAN MAOB Amine oxidase [flavin-containing] B 3.515e-10 0.45
ANDR_HUMAN AR Androgen receptor 4.159e-10 0.45
CASP9_HUMAN CASP9 Caspase-9 4.245e-10 0.36
CAH9_HUMAN CA9 Carbonic anhydrase 9 4.47e-10 0.57
ALDR_RAT Akr1b1 Aldo-keto reductase family 1 member B1 6.8e-10 0.42
PETD_SPIOL petD Cytochrome b6-f complex subunit 4 7.597e-10 0.37
RL19A_YEAST RPL19A 60S ribosomal protein L19-A 7.983e-10 0.36
PDE7B_HUMAN PDE7B cAMP-specific 3',5'-cyclic phosphodiesterase 7B 9.68e-10 0.31
5HT1E_HUMAN HTR1E 5-hydroxytryptamine receptor 1E 1.037e-09 0.39
CFTR_HUMAN CFTR Cystic fibrosis transmembrane conductance regulator 1.071e-09 0.41
SMAD3_HUMAN SMAD3 Mothers against decapentaplegic homolog 3 1.081e-09 0.39
PSDE_HUMAN PSMD14 26S proteasome non-ATPase regulatory subunit 14 1.215e-09 0.35
HAOX1_HUMAN HAO1 Hydroxyacid oxidase 1 1.314e-09 0.36
Q932Y6_PSEAI bla(tem-2) Beta-lactamase 1.339e-09 0.59
PRGR_HUMAN PGR Progesterone receptor 1.344e-09 0.42
FEN1_HUMAN FEN1 Flap endonuclease 1 1.563e-09 0.36
OXDA_PIG DAO D-amino-acid oxidase 1.563e-09 0.34
GBRG2_RAT Gabrg2 Gamma-aminobutyric acid receptor subunit gamma-2 1.688e-09 0.33
PPBT_MOUSE Alpl Alkaline phosphatase, tissue-nonspecific isozyme 1.863e-09 0.30
P90584_PLAFA Pfmrk MO15-related protein kinase Pfmrk 1.968e-09 0.35
GSTA1_HUMAN GSTA1 Glutathione S-transferase A1 2.391e-09 0.35
IF4H_HUMAN EIF4H Eukaryotic translation initiation factor 4H 2.411e-09 0.32
NF2L2_HUMAN NFE2L2 Nuclear factor erythroid 2-related factor 2 2.58e-09 0.44
PGH2_SHEEP PTGS2 Prostaglandin G/H synthase 2 2.601e-09 0.45
CATL2_HUMAN CTSV Cathepsin L2 2.737e-09 0.39
CH10_HUMAN HSPE1 10 kDa heat shock protein, mitochondrial 2.944e-09 0.31
CH60_HUMAN HSPD1 60 kDa heat shock protein, mitochondrial 2.944e-09 0.31
B9W6M3_CANDC CNA1 Serine/threonine-protein phosphatase 2.967e-09 0.36
O31272_9GAMM imiS Beta-lactamase 3.598e-09 0.29
PPME1_MOUSE Ppme1 Protein phosphatase methylesterase 1 3.598e-09 0.29
DNAB_MYCTU dnaB Replicative DNA helicase 3.899e-09 0.49
SENP7_HUMAN SENP7 Sentrin-specific protease 7 4.279e-09 0.48
KCNA1_HUMAN KCNA1 Potassium voltage-gated channel subfamily A member 1 4.608e-09 0.28
KCNA4_HUMAN KCNA4 Potassium voltage-gated channel subfamily A member 4 4.608e-09 0.28
NQO2_HUMAN NQO2 Ribosyldihydronicotinamide dehydrogenase [quinone] 5.958e-09 0.41
KAT2A_HUMAN KAT2A Histone acetyltransferase KAT2A 6.138e-09 0.30
HS90A_HUMAN HSP90AA1 Heat shock protein HSP 90-alpha 6.532e-09 0.47
GSHR_HUMAN GSR Glutathione reductase, mitochondrial 7.339e-09 0.37
CSK_HUMAN CSK Tyrosine-protein kinase CSK 7.449e-09 0.41
TNNC1_HUMAN TNNC1 Troponin C, slow skeletal and cardiac muscles 7.515e-09 0.44
TNNI3_HUMAN TNNI3 Troponin I, cardiac muscle 7.515e-09 0.44
TNNT2_HUMAN TNNT2 Troponin T, cardiac muscle 7.515e-09 0.44
HYEP_MOUSE Ephx1 Epoxide hydrolase 1 1.008e-08 0.40
ACES_RAT Ache Acetylcholinesterase 1.038e-08 0.37
MK14_RAT Mapk14 Mitogen-activated protein kinase 14 1.18e-08 0.47
CAH2_HUMAN CA2 Carbonic anhydrase 2 1.233e-08 0.57
PDE4C_HUMAN PDE4C cAMP-specific 3',5'-cyclic phosphodiesterase 4C 1.271e-08 0.37
Q9BEG3_BOVIN 5-lipoxygenase 1.912e-08 0.44
MAZF_ECOLI mazF Endoribonuclease toxin MazF 1.919e-08 0.33
MMP12_HUMAN MMP12 Macrophage metalloelastase 2.004e-08 0.33
MMP2_HUMAN MMP2 72 kDa type IV collagenase 2.076e-08 0.47
NRAM2_HUMAN SLC11A2 Natural resistance-associated macrophage protein 2 2.095e-08 0.39
RECA_MYCTU recA Protein RecA 2.36e-08 0.47
DPOL_HHV6U U38 DNA polymerase catalytic subunit 2.8e-08 0.29
PDE7A_HUMAN PDE7A High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A 2.965e-08 0.42
S22A2_RAT Slc22a2 Solute carrier family 22 member 2 3.541e-08 0.32
TIM10_YEAST TIM10 Mitochondrial import inner membrane translocase subunit TIM10 3.976e-08 0.46
NLRP3_HUMAN NLRP3 NACHT, LRR and PYD domains-containing protein 3 5.117e-08 0.36
S22A6_RAT Slc22a6 Solute carrier family 22 member 6 5.219e-08 0.30
KPCG_RAT Prkcg Protein kinase C gamma type 5.317e-08 0.31
CP2CJ_HUMAN CYP2C19 Cytochrome P450 2C19 5.801e-08 0.52
ALR_HUMAN GFER FAD-linked sulfhydryl oxidase ALR 7.101e-08 0.44
A4_HUMAN APP Amyloid-beta precursor protein 7.827e-08 0.56
GBRA2_RAT Gabra2 Gamma-aminobutyric acid receptor subunit alpha-2 7.894e-08 0.33
SGMR2_HUMAN TMEM97 Sigma intracellular receptor 2 7.899e-08 0.36
MMP9_HUMAN MMP9 Matrix metalloproteinase-9 8.428e-08 0.47
PARP1_MOUSE Parp1 Poly [ADP-ribose] polymerase 1 8.846e-08 0.38
LOX5_HUMAN ALOX5 Arachidonate 5-lipoxygenase 9.107e-08 0.47
EST1_HUMAN CES1 Liver carboxylesterase 1 1.064e-07 0.59
PGH1_MOUSE Ptgs1 Prostaglandin G/H synthase 1 1.124e-07 0.30
ABC3G_HUMAN APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G 1.263e-07 0.39
Q9BHT9_PLABE G6PD-6PGL Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 1.34e-07 0.36
MAP1_ECOLI map Methionine aminopeptidase 1.563e-07 0.33
TTHY_HUMAN TTR Transthyretin 1.656e-07 0.38
CAH1_HUMAN CA1 Carbonic anhydrase 1 1.671e-07 0.57
CAH2_BOVIN CA2 Carbonic anhydrase 2 1.796e-07 0.46
PSBA_SPIOL psbA Photosystem II protein D1 2.005e-07 0.37
WDR5_HUMAN WDR5 WD repeat-containing protein 5 2.369e-07 0.33
HDAC2_HUMAN HDAC2 Histone deacetylase 2 2.609e-07 0.37
AMYP_PIG AMY2 Pancreatic alpha-amylase 2.749e-07 0.31
PMM2_HUMAN PMM2 Phosphomannomutase 2 2.786e-07 0.28
AK1C1_HUMAN AKR1C1 Aldo-keto reductase family 1 member C1 2.832e-07 0.39
ACES_MOUSE Ache Acetylcholinesterase 2.879e-07 0.35
CP1A2_HUMAN CYP1A2 Cytochrome P450 1A2 2.903e-07 0.40
CP2C9_HUMAN CYP2C9 Cytochrome P450 2C9 3.197e-07 0.49
S22A1_RAT Slc22a1 Solute carrier family 22 member 1 3.211e-07 0.32
AGP1_YEAST AGP1 General amino acid permease AGP1 3.411e-07 0.36
DUS3_HUMAN DUSP3 Dual specificity protein phosphatase 3 3.752e-07 0.33
ASAH1_HUMAN ASAH1 Acid ceramidase 3.966e-07 0.31
MCL1_HUMAN MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 4.048e-07 0.44
TYSY_LACCA thyA Thymidylate synthase 5.144e-07 0.31
Q6QLK5_9HIV1 env Envelope glycoprotein gp160 5.239e-07 0.34
FABI_BACSU fabI Enoyl-[acyl-carrier-protein] reductase [NADH] FabI 5.622e-07 0.28
CTDS1_HUMAN CTDSP1 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 5.635e-07 0.39
PHOP1_HUMAN PHOSPHO1 Phosphoethanolamine/phosphocholine phosphatase 8.274e-07 0.29
SERA_HUMAN PHGDH D-3-phosphoglycerate dehydrogenase 9.855e-07 0.31
Q7T1G6_DANRE trpn1 Ion channel NompC 1.003e-06 0.40
PNMT_HUMAN PNMT Phenylethanolamine N-methyltransferase 1.042e-06 0.33
LGUL_HUMAN GLO1 Lactoylglutathione lyase 1.291e-06 0.31
ATS4_HUMAN ADAMTS4 A disintegrin and metalloproteinase with thrombospondin motifs 4 1.652e-06 0.32
HSF1_MOUSE Hsf1 Heat shock factor protein 1 1.671e-06 0.42
DXR_MYCTU dxr 1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.68e-06 0.29
XBP1_HUMAN XBP1 X-box-binding protein 1 1.718e-06 0.46
PGH2_HUMAN PTGS2 Prostaglandin G/H synthase 2 2.039e-06 0.47
Q8MWR1_SPOFR USP Ultraspiracle protein 2.104e-06 0.33
Q8MWR2_SPOFR EcR Ecdysteroid receptor 2.104e-06 0.33
AOFA_HUMAN MAOA Amine oxidase [flavin-containing] A 2.185e-06 0.39
DLDH_MYCTU lpdC Dihydrolipoyl dehydrogenase 2.301e-06 0.44
VCAM1_HUMAN VCAM1 Vascular cell adhesion protein 1 2.376e-06 0.37
PRIO_SHEEP PRNP Major prion protein 2.409e-06 0.29
ABCC8_HUMAN ABCC8 ATP-binding cassette sub-family C member 8 2.417e-06 0.38
BLA1_STEMA Metallo-beta-lactamase L1 type 3 2.456e-06 0.28
Q9BPW0_HUMAN PPP5C Serine/threonine-protein phosphatase 2.494e-06 0.36
O49150_SOLTU Lipoxygenase 2.65e-06 0.31
MDM4_HUMAN MDM4 Protein Mdm4 2.754e-06 0.40
PTN11_HUMAN PTPN11 Tyrosine-protein phosphatase non-receptor type 11 2.763e-06 0.34
Q79MP6_PSEAI blaIMP-1 Beta-lactamase 2.861e-06 0.31
CAH13_MOUSE Ca13 Carbonic anhydrase 13 3.048e-06 0.41
KPCA_MOUSE Prkca Protein kinase C alpha type 3.264e-06 0.32
DRTS_LEIMA Bifunctional dihydrofolate reductase-thymidylate synthase 3.559e-06 0.29
O69002_PSEAI pigA Biliverdin-producing heme oxygenase 3.596e-06 0.33
DXR_ECOLI dxr 1-deoxy-D-xylulose 5-phosphate reductoisomerase 4.126e-06 0.34
STAT1_HUMAN STAT1 Signal transducer and activator of transcription 1-alpha/beta 4.241e-06 0.33
S29A1_HUMAN SLC29A1 Equilibrative nucleoside transporter 1 4.435e-06 0.32
COMT_RAT Comt Catechol O-methyltransferase 4.789e-06 0.30
DUS22_HUMAN DUSP22 Dual specificity protein phosphatase 22 5.16e-06 0.28
PSB8_HUMAN PSMB8 Proteasome subunit beta type-8 5.673e-06 0.35
LUCI_PHOPY Luciferin 4-monooxygenase 5.705e-06 0.44
AMPL_PIG LAP3 Cytosol aminopeptidase 5.943e-06 0.32
CP19A_RAT Cyp19a1 Aromatase 6.936e-06 0.43
PASK_HUMAN PASK PAS domain-containing serine/threonine-protein kinase 7.112e-06 0.29
LUCI_AQULA Luciferin 4-monooxygenase 8.279e-06 0.28
HPRT_HUMAN HPRT1 Hypoxanthine-guanine phosphoribosyltransferase 8.795e-06 0.48
EAA1_HUMAN SLC1A3 Excitatory amino acid transporter 1 9.273e-06 0.33
C11B1_HUMAN CYP11B1 Cytochrome P450 11B1, mitochondrial 9.833e-06 0.37

Benznidazole

SMS1_HUMAN SGMS1 Phosphatidylcholine:ceramide cholinephosphotransferase 1 1.713e-49 0.32
NOS3_MOUSE Nos3 Nitric oxide synthase, endothelial 5.881e-40 0.32
PYGM_RAT Pygm Glycogen phosphorylase, muscle form 2.512e-34 0.34
ACOD1_MOUSE Scd1 Acyl-CoA desaturase 1 1.252e-28 0.35
C11B1_RAT Cyp11b1 Cytochrome P450 11B1, mitochondrial 5.859e-25 0.32
PDS_SYNE7 pds 15-cis-phytoene desaturase 8.339e-25 0.35
NAMPT_RAT Nampt Nicotinamide phosphoribosyltransferase 6.243e-24 0.29
EGLN1_HUMAN EGLN1 Egl nine homolog 1 5.412e-23 0.38
CAC1G_HUMAN CACNA1G Voltage-dependent T-type calcium channel subunit alpha-1G 5.865e-23 0.36
Q9FD53_STREE mvaD Diphosphomevalonate decarboxylase 3.49e-22 0.32
ERO1A_HUMAN ERO1A ERO1-like protein alpha 6.654e-21 0.33
THRB_HUMAN F2 Prothrombin 1.048e-19 0.36
AMP1_PLAFQ M1 family aminopeptidase 1.592e-19 0.35
BKRB2_RAT Bdkrb2 B2 bradykinin receptor 2.324e-19 0.37
CAC1I_HUMAN CACNA1I Voltage-dependent T-type calcium channel subunit alpha-1I 1.27e-18 0.31
ASAH1_HUMAN ASAH1 Acid ceramidase 1.89e-18 0.37
TGM2_CAVCU TGM2 Protein-glutamine gamma-glutamyltransferase 2 6.556e-18 0.28
VE1_HPV11 E1 Replication protein E1 1.376e-17 0.35
DPOL_HHV6U U38 DNA polymerase catalytic subunit 2.22e-16 0.32
ENPL_CANLF HSP90B1 Endoplasmin 2.22e-16 0.33
STF1_HUMAN NR5A1 Steroidogenic factor 1 2.22e-16 0.38
HYEP_MOUSE Ephx1 Epoxide hydrolase 1 5.551e-16 0.39
BRAF_MOUSE Braf Serine/threonine-protein kinase B-raf 6.661e-16 0.33
SCN3A_RAT Scn3a Sodium channel protein type 3 subunit alpha 1.11e-15 0.30
NMDE2_HUMAN GRIN2B Glutamate receptor ionotropic, NMDA 2B 1.221e-15 0.34
ACOD_HUMAN SCD Acyl-CoA desaturase 2.331e-15 0.35
TRPA1_RAT Trpa1 Transient receptor potential cation channel subfamily A member 1 4.996e-14 0.34
GYRB_MYCS2 gyrB DNA gyrase subunit B 6.184e-14 0.33
PYGM_RABIT PYGM Glycogen phosphorylase, muscle form 9.293e-14 0.44
GBRA1_RAT Gabra1 Gamma-aminobutyric acid receptor subunit alpha-1 2.017e-13 0.38
GBRB2_RAT Gabrb2 Gamma-aminobutyric acid receptor subunit beta-2 3.544e-13 0.38
ATS5_HUMAN ADAMTS5 A disintegrin and metalloproteinase with thrombospondin motifs 5 6.737e-13 0.36
P2RX4_HUMAN P2RX4 P2X purinoceptor 4 1.124e-12 0.29
NAMPT_MOUSE Nampt Nicotinamide phosphoribosyltransferase 1.167e-12 0.30
Q7ZJM1_9HIV1 pol Integrase 1.505e-12 0.38
GBRG2_RAT Gabrg2 Gamma-aminobutyric acid receptor subunit gamma-2 3.334e-12 0.38
Q8VH26_CAVPO GPM3 Muscarinic acetylcholine receptor 4.468e-12 0.31
NAMPT_HUMAN NAMPT Nicotinamide phosphoribosyltransferase 1.276e-11 0.37
HYEP_HUMAN EPHX1 Epoxide hydrolase 1 2.033e-11 0.39
PPIB_HUMAN PPIB Peptidyl-prolyl cis-trans isomerase B 6.536e-11 0.29
INHA_MYCTU inhA Enoyl-[acyl-carrier-protein] reductase [NADH] 8.061e-11 0.39
ENPP2_HUMAN ENPP2 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 1.198e-10 0.37
CAC1H_HUMAN CACNA1H Voltage-dependent T-type calcium channel subunit alpha-1H 1.568e-10 0.31
KDM4D_HUMAN KDM4D Lysine-specific demethylase 4D 2.29e-10 0.31
CATL2_HUMAN CTSV Cathepsin L2 6.248e-10 0.31
CH10_HUMAN HSPE1 10 kDa heat shock protein, mitochondrial 6.557e-10 0.33
CH60_HUMAN HSPD1 60 kDa heat shock protein, mitochondrial 6.557e-10 0.33
P2RX4_MOUSE P2rx4 P2X purinoceptor 4 7.541e-10 0.29
AA1R_BOVIN ADORA1 Adenosine receptor A1 1.536e-09 0.36
H9B8T9_CAPHI CTSB Cathepsin B 2.022e-09 0.30
Q533H1_FELCA UTS2R Urotensin II receptor 2.184e-09 0.29
PPIG_HUMAN PPIG Peptidyl-prolyl cis-trans isomerase G 2.304e-09 0.29
Q76353_9HIV1 Integrase 2.327e-09 0.36
NCEH1_HUMAN NCEH1 Neutral cholesterol ester hydrolase 1 3.911e-09 0.32
5HT7R_CAVPO HTR7 5-hydroxytryptamine receptor 7 4.08e-09 0.30
CHLE_HUMAN BCHE Cholinesterase 4.78e-09 0.39
COMT_RAT Comt Catechol O-methyltransferase 6.219e-09 0.32
PORCN_MOUSE Porcn Protein-serine O-palmitoleoyltransferase porcupine 8.398e-09 0.31
AMPN_PIG ANPEP Aminopeptidase N 9.97e-09 0.36
P2RX4_RAT P2rx4 P2X purinoceptor 4 1.322e-08 0.29
KLK6_HUMAN KLK6 Kallikrein-6 2.195e-08 0.30
GSK3B_MOUSE Gsk3b Glycogen synthase kinase-3 beta 3.012e-08 0.31
GBRA2_RAT Gabra2 Gamma-aminobutyric acid receptor subunit alpha-2 4.031e-08 0.35
NR1I2_HUMAN NR1I2 Nuclear receptor subfamily 1 group I member 2 4.615e-08 0.33
FCER2_HUMAN FCER2 Low affinity immunoglobulin epsilon Fc receptor 5.177e-08 0.30
PPIA_HUMAN PPIA Peptidyl-prolyl cis-trans isomerase A 5.836e-08 0.35
PLCG2_HUMAN PLCG2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 7.127e-08 0.29
METC_ECOLI metC Cystathionine beta-lyase MetC 1.214e-07 0.30
GBRA5_RAT Gabra5 Gamma-aminobutyric acid receptor subunit alpha-5 2.011e-07 0.35
S12A2_HUMAN SLC12A2 Solute carrier family 12 member 2 2.022e-07 0.32
UBC9_HUMAN UBE2I SUMO-conjugating enzyme UBC9 2.069e-07 0.32
CBPA1_HUMAN CPA1 Carboxypeptidase A1 2.447e-07 0.31
GBRB3_RAT Gabrb3 Gamma-aminobutyric acid receptor subunit beta-3 2.539e-07 0.35
RORA_HUMAN RORA Nuclear receptor ROR-alpha 2.564e-07 0.38
PA_I34A1 PA Polymerase acidic protein 2.804e-07 0.31
GBRA3_RAT Gabra3 Gamma-aminobutyric acid receptor subunit alpha-3 2.905e-07 0.35
FABI_BACSU fabI Enoyl-[acyl-carrier-protein] reductase [NADH] FabI 3.205e-07 0.29
PLPL6_MOUSE Pnpla6 Neuropathy target esterase 3.445e-07 0.31
PPID_HUMAN PPID Peptidyl-prolyl cis-trans isomerase D 4.396e-07 0.29
EGFR_MOUSE Egfr Epidermal growth factor receptor 4.905e-07 0.29
PANC_MYCTU panC Pantothenate synthetase 5.377e-07 0.35
KDM4E_HUMAN KDM4E Lysine-specific demethylase 4E 5.916e-07 0.31
Q6FTL6_CANGA NCE103 Carbonic anhydrase 7.169e-07 0.32
FUCO_RAT Fuca1 Tissue alpha-L-fucosidase 7.608e-07 0.33
TRY1_HUMAN PRSS1 Trypsin-1 7.735e-07 0.34
SGMR2_HUMAN TMEM97 Sigma intracellular receptor 2 7.793e-07 0.31
CAH5A_HUMAN CA5A Carbonic anhydrase 5A, mitochondrial 7.817e-07 0.38
A0A0C7ACN7_PSEAI pqsD 3-oxoacyl-ACP synthase 9.396e-07 0.29
TNR6_RAT Fas Tumor necrosis factor receptor superfamily member 6 9.408e-07 0.30
EGLN3_HUMAN EGLN3 Egl nine homolog 3 1.531e-06 0.31
KDM6B_HUMAN KDM6B Lysine-specific demethylase 6B 1.631e-06 0.31
TRPA1_HUMAN TRPA1 Transient receptor potential cation channel subfamily A member 1 1.637e-06 0.34
CAH1_HUMAN CA1 Carbonic anhydrase 1 1.687e-06 0.73
RCOR1_HUMAN RCOR1 REST corepressor 1 1.892e-06 0.39
SENP1_HUMAN SENP1 Sentrin-specific protease 1 1.959e-06 0.29
ERCC1_HUMAN ERCC1 DNA excision repair protein ERCC-1 2.196e-06 0.33
XPF_HUMAN ERCC4 DNA repair endonuclease XPF 2.196e-06 0.33
Q38C41_TRYB2 Phosphotransferase 2.26e-06 0.42
CAH2_HUMAN CA2 Carbonic anhydrase 2 3.083e-06 0.73
LYOX_HUMAN LOX Protein-lysine 6-oxidase 3.469e-06 0.30
CP2CJ_HUMAN CYP2C19 Cytochrome P450 2C19 3.88e-06 0.35
CAH4_HUMAN CA4 Carbonic anhydrase 4 3.976e-06 0.33
TRYB1_HUMAN TPSAB1 Tryptase alpha/beta-1 3.987e-06 0.31
Q3I4V7_CRYNV CAN2 Carbonic anhydrase 4.037e-06 0.35
CTDS1_HUMAN CTDSP1 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 4.076e-06 0.43
P2RX1_HUMAN P2RX1 P2X purinoceptor 1 4.596e-06 0.29
EGFR_HUMAN EGFR Epidermal growth factor receptor 5.801e-06 0.36
PPCE_PIG PREP Prolyl endopeptidase 5.997e-06 0.31
5HT7R_RAT Htr7 5-hydroxytryptamine receptor 7 7.261e-06 0.31
C3SIU2_ECOLX metJ Met repressor 8.833e-06 0.28
AOFA_BOVIN MAOA Amine oxidase [flavin-containing] A 9.886e-06 0.37

Bempedoic_acid

CP4A4_RABIT CYP4A4 Cytochrome P450 4A4 1.431e-47 0.38
S22AK_MOUSE Slc22a20 Solute carrier family 22 member 20 3.612e-26 0.29
LT4R1_HUMAN LTB4R Leukotriene B4 receptor 1 2.552e-19 0.38
ACLY_HUMAN ACLY ATP-citrate synthase 6.137e-18 0.29
CBPB1_PIG CPB1 Carboxypeptidase B 1.004e-13 0.30
ACLY_RAT Acly ATP-citrate synthase 1.111e-11 0.39
PE2R2_RAT Ptger2 Prostaglandin E2 receptor EP2 subtype 5.54e-10 0.34
AMPD2_HUMAN AMPD2 AMP deaminase 2 1.385e-06 0.30
HDAC6_MOUSE Hdac6 Histone deacetylase 6 3.865e-06 0.33

Deutetrabenazine

VMAT2_RAT Slc18a2 Synaptic vesicular amine transporter 1.244e-45 0.78
DRD1_HUMAN DRD1 D(1A) dopamine receptor 2.796e-38 0.41
VMAT2_MOUSE Slc18a2 Synaptic vesicular amine transporter 1.636e-37 0.48
VMAT2_HUMAN SLC18A2 Synaptic vesicular amine transporter 3.598e-34 0.48
VMAT2_BOVIN SLC18A2 Synaptic vesicular amine transporter 1.629e-25 0.78
HCN2_MOUSE Hcn2 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 6.375e-18 0.28
RBBP9_HUMAN RBBP9 Serine hydrolase RBBP9 3.741e-13 0.36
HCN1_MOUSE Hcn1 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 4.751e-13 0.28
TF_HUMAN F3 Tissue factor 1.237e-11 0.39
DRD5_HUMAN DRD5 D(1B) dopamine receptor 2.941e-10 0.39
KCNN1_HUMAN KCNN1 Small conductance calcium-activated potassium channel protein 1 1.91e-09 0.30
MTR1B_HUMAN MTNR1B Melatonin receptor type 1B 6.046e-08 0.33
KCNN2_HUMAN KCNN2 Small conductance calcium-activated potassium channel protein 2 6.101e-08 0.30
DPP4_HUMAN DPP4 Dipeptidyl peptidase 4 8.173e-08 0.40

Avatrombopag

TPOR_HUMAN MPL Thrombopoietin receptor 1.665e-44 0.57
CXCR3_HUMAN CXCR3 C-X-C chemokine receptor type 3 1.275e-30 0.45
CXCR3_RAT Cxcr3 C-X-C chemokine receptor type 3 1.051e-28 0.43
O70424_RAT Neuropeptide Y-Y2 receptor 2.621e-19 0.31
P2Y12_HUMAN P2RY12 P2Y purinoceptor 12 6.661e-16 0.36
MALT1_HUMAN MALT1 Mucosa-associated lymphoid tissue lymphoma translocation protein 1 2.232e-11 0.31
CXCR3_MOUSE Cxcr3 C-X-C chemokine receptor type 3 1.676e-10 0.43
SMN_HUMAN SMN1; SMN2 Survival motor neuron protein 3.468e-09 0.34
HRH3_MOUSE Hrh3 Histamine H3 receptor 1.658e-08 0.32
ACKR3_HUMAN ACKR3 Atypical chemokine receptor 3 4.862e-07 0.33
ABL1_HUMAN ABL1 Tyrosine-protein kinase ABL1 1.81e-06 0.34
NPY2R_HUMAN NPY2R Neuropeptide Y receptor type 2 8.305e-06 0.32
NEK2_HUMAN NEK2 Serine/threonine-protein kinase Nek2 9.024e-06 0.31

Triclabendazole

AAKG1_HUMAN PRKAG1 5'-AMP-activated protein kinase subunit gamma-1 1.046e-42 0.40
AAPK2_HUMAN PRKAA2 5'-AMP-activated protein kinase catalytic subunit alpha-2 2.519e-39 0.40
AAKB1_HUMAN PRKAB1 5'-AMP-activated protein kinase subunit beta-1 4.869e-38 0.40
AAKG2_HUMAN PRKAG2 5'-AMP-activated protein kinase subunit gamma-2 1.215e-35 0.28
TFDP2_HUMAN TFDP2 Transcription factor Dp-2 1.215e-35 0.28
AAKG3_HUMAN PRKAG3 5'-AMP-activated protein kinase subunit gamma-3 5.889e-23 0.28
AAKB2_HUMAN PRKAB2 5'-AMP-activated protein kinase subunit beta-2 8.52e-18 0.28
THIO_HUMAN TXN Thioredoxin 1.11e-16 0.34
CCG8_HUMAN CACNG8 Voltage-dependent calcium channel gamma-8 subunit 1.554e-15 0.30
Q9RMI3_STAAU fabI Enoyl-[acyl-carrier-protein] reductase [NADPH] 1.41e-14 0.32
OPRX_HUMAN OPRL1 Nociceptin receptor 8.197e-09 0.37

Zytron

ODPA_PEA Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial 4.694e-40 0.32
ODPB_PEA Pyruvate dehydrogenase E1 component subunit beta, mitochondrial 4.694e-40 0.32
Q965D5_PLAFA fabI Enoyl-acyl-carrier protein reductase 6.473e-40 0.35
FA8_HUMAN F8 Coagulation factor VIII 4.185e-23 0.28
Q9BJJ9_PLAFA FabI Enoyl-ACP reductase 7.766e-22 0.35
Q6UCJ9_TOXGO ENR Enoyl-acyl carrier reductase 3.331e-15 0.35
Q5NGQ3_FRATT fabI Enoyl-[acyl-carrier-protein] reductase [NADH] 3.73e-14 0.35
TTHY_HUMAN TTR Transthyretin 4.224e-13 0.35
PLCB_HUMAN AGPAT2 1-acyl-sn-glycerol-3-phosphate acyltransferase beta 4.014e-12 0.29
PPOC_ARATH PPOX1 Protoporphyrinogen oxidase 1, chloroplastic 2.659e-10 0.30
M9TGV3_MYCTX inhA Enoyl-[acyl-carrier-protein] reductase [NADH] 2.851e-10 0.35
S1PR4_HUMAN S1PR4 Sphingosine 1-phosphate receptor 4 3.191e-10 0.32
TRPV4_MOUSE Trpv4 Transient receptor potential cation channel subfamily V member 4 5.162e-10 0.29
CBR1_HUMAN CBR1 Carbonyl reductase [NADPH] 1 3.009e-09 0.35
KCNJ2_MOUSE Kcnj2 Inward rectifier potassium channel 2 1.111e-08 0.29
FABI_BACSU fabI Enoyl-[acyl-carrier-protein] reductase [NADH] FabI 2.009e-08 0.35
Q8MTZ4_9TRYP PPase1 Vacuolar-type proton translocating pyrophosphatase 1 7.045e-07 0.29

Tecovirimat

SRPK1_MOUSE Srpk1 SRSF protein kinase 1 1.071e-38 0.31
E2AK3_RAT Eif2ak3 Eukaryotic translation initiation factor 2-alpha kinase 3 5.953e-37 0.29
WNT3_HUMAN WNT3 Proto-oncogene Wnt-3 5.102e-35 0.34
SC6A5_HUMAN SLC6A5 Sodium- and chloride-dependent glycine transporter 2 1.413e-19 0.34
ECR_AEDAE EcR Ecdysone receptor 2.106e-17 0.34
ELOV6_HUMAN ELOVL6 Elongation of very long chain fatty acids protein 6 5.261e-13 0.36
TRAR_RHIRD traR Transcriptional activator protein TraR 1.963e-11 0.31
ELOV6_MOUSE Elovl6 Elongation of very long chain fatty acids protein 6 5.575e-10 0.29
HYES_MOUSE Ephx2 Bifunctional epoxide hydrolase 2 7.575e-10 0.30
PSBA_MARPO psbA Photosystem II protein D1 2.039e-09 0.29
ELOV3_HUMAN ELOVL3 Elongation of very long chain fatty acids protein 3 2.72e-09 0.29
HYES_HUMAN EPHX2 Bifunctional epoxide hydrolase 2 1.005e-08 0.33
LUXS_ALIF1 luxR Transcriptional activator protein LuxR 1.035e-08 0.31
MURB_ECOLI murB UDP-N-acetylenolpyruvoylglucosamine reductase 1.051e-08 0.31
CAC1B_HUMAN CACNA1B Voltage-dependent N-type calcium channel subunit alpha-1B 1.363e-08 0.31
AADAT_RAT Aadat Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial 1.383e-08 0.30
PTPA_MYCTU ptpA Probable low molecular weight protein-tyrosine-phosphatase 1.711e-08 0.31
AADAT_HUMAN AADAT Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial 2.118e-08 0.30
TRPV4_HUMAN TRPV4 Transient receptor potential cation channel subfamily V member 4 4.689e-08 0.37
TRPV4_RAT Trpv4 Transient receptor potential cation channel subfamily V member 4 7.142e-08 0.35
UCHL1_HUMAN UCHL1 Ubiquitin carboxyl-terminal hydrolase isozyme L1 1.264e-07 0.31
EST2_HUMAN CES2 Cocaine esterase 3.874e-07 0.39
PYRD_RAT Dhodh Dihydroorotate dehydrogenase (quinone), mitochondrial 1.049e-06 0.29
SGMR1_MOUSE Sigmar1 Sigma non-opioid intracellular receptor 1 2.542e-06 0.33
DCMC_HUMAN MLYCD Malonyl-CoA decarboxylase, mitochondrial 3.408e-06 0.30
Q8MWR1_SPOFR USP Ultraspiracle protein 4.884e-06 0.31
Q8MWR2_SPOFR EcR Ecdysteroid receptor 4.884e-06 0.31
RXFP1_HUMAN RXFP1 Relaxin receptor 1 7.429e-06 0.30

Vaborbactam

BLA1_STEMA Metallo-beta-lactamase L1 type 3 5.354e-38 0.41
CATG_MOUSE Ctsg Cathepsin G 2.847e-23 0.29
S22AB_HUMAN SLC22A11 Solute carrier family 22 member 11 2.62e-21 0.35
B2ZTR6_ACIBA Beta-lactamase 2.322e-19 0.31
D6NSM8_ACIBA ampC Beta-lactamase 2.322e-19 0.31
PRTN3_MOUSE Prtn3 Myeloblastin 4.879e-18 0.29
A2RP81_CITFR blaPER-2 Beta-lactamase 4.43e-14 0.31
S22A8_HUMAN SLC22A8 Solute carrier family 22 member 8 2.536e-13 0.35
PTPRF_HUMAN PTPRF Receptor-type tyrosine-protein phosphatase F 2.089e-12 0.31
ELNE_MOUSE Elane Neutrophil elastase 9.7e-12 0.29
S22A6_HUMAN SLC22A6 Solute carrier family 22 member 6 1.048e-10 0.35
S15A2_RAT Slc15a2 Solute carrier family 15 member 2 2.006e-10 0.35
CAH5B_HUMAN CA5B Carbonic anhydrase 5B, mitochondrial 6.681e-10 0.36
CAH5A_HUMAN CA5A Carbonic anhydrase 5A, mitochondrial 2.03e-08 0.36
CTDS1_HUMAN CTDSP1 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 2.479e-08 0.37
AROQ_MYCTU aroQ 3-dehydroquinate dehydratase 7.304e-08 0.30
GCN5_YEAST GCN5 Histone acetyltransferase GCN5 3.869e-07 0.36
DNMT1_HUMAN DNMT1 DNA (cytosine-5)-methyltransferase 1 9.646e-06 0.35

Letermovir

PAI1_HUMAN SERPINE1 Plasminogen activator inhibitor 1 2.422e-36 0.37
D3ZFJ0_RAT Pik3cg Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 3.875e-36 0.29
HDP_PLAF7 HDP Heme ligase 1.71e-35 0.28
SERA_HUMAN PHGDH D-3-phosphoglycerate dehydrogenase 3.26e-28 0.29
5HT1D_MOUSE Htr1d 5-hydroxytryptamine receptor 1D 1.694e-22 0.29
5HT1A_RAT Htr1a 5-hydroxytryptamine receptor 1A 1.105e-19 0.37
LIPL_HUMAN LPL Lipoprotein lipase 3.886e-18 0.29
FFAR1_HUMAN FFAR1 Free fatty acid receptor 1 4.027e-18 0.40
KCMA1_RAT Kcnma1 Calcium-activated potassium channel subunit alpha-1 2.22e-16 0.31
SSR1_RAT Sstr1 Somatostatin receptor type 1 2.442e-15 0.36
FFAR4_MOUSE Ffar4 Free fatty acid receptor 4 3.109e-15 0.35
FFAR4_RAT Ffar4 Free fatty acid receptor 4 3.664e-15 0.29
NMDE3_RAT Grin2c Glutamate receptor ionotropic, NMDA 2C 5.773e-15 0.37
CAC1G_HUMAN CACNA1G Voltage-dependent T-type calcium channel subunit alpha-1G 1.477e-14 0.41
FDFT_RAT Fdft1 Squalene synthase 2.631e-14 0.35
BRS3_MOUSE Brs3 Bombesin receptor subtype-3 1.302e-13 0.31
NMDE4_RAT Grin2d Glutamate receptor ionotropic, NMDA 2D 4.525e-13 0.37
MAOX_HUMAN ME1 NADP-dependent malic enzyme 8.579e-13 0.31
FFAR1_MOUSE Ffar1 Free fatty acid receptor 1 9.099e-13 0.34
Q76129_9HIV1 gag Structural capsid protein 1.806e-12 0.36
CA2D2_RAT Cacna2d2 Voltage-dependent calcium channel subunit alpha-2/delta-2 4.114e-12 0.30
CACB1_HUMAN CACNB1 Voltage-dependent L-type calcium channel subunit beta-1 4.114e-12 0.30
GTR3_HUMAN SLC2A3 Solute carrier family 2, facilitated glucose transporter member 3 6.516e-12 0.31
CP24A_RAT Cyp24a1 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial 8.394e-12 0.29
GTR2_HUMAN SLC2A2 Solute carrier family 2, facilitated glucose transporter member 2 1.131e-11 0.31
RET4_HUMAN RBP4 Retinol-binding protein 4 1.687e-11 0.30
CAC1A_HUMAN CACNA1A Voltage-dependent P/Q-type calcium channel subunit alpha-1A 5.087e-11 0.30
5HT7R_HUMAN HTR7 5-hydroxytryptamine receptor 7 6.67e-11 0.35
BRS3_HUMAN BRS3 Bombesin receptor subtype-3 1.422e-10 0.31
DRD4_HUMAN DRD4 D(4) dopamine receptor 6.774e-10 0.34
DRD2_RAT Drd2 D(2) dopamine receptor 1.106e-09 0.37
PPGB_HUMAN CTSA Lysosomal protective protein 5.231e-09 0.33
5HT7R_RAT Htr7 5-hydroxytryptamine receptor 7 8.931e-09 0.32
CCR1_HUMAN CCR1 C-C chemokine receptor type 1 1.741e-08 0.37
PD2R2_HUMAN PTGDR2 Prostaglandin D2 receptor 2 1.775e-08 0.34
DCTP1_HUMAN DCTPP1 dCTP pyrophosphatase 1 1.793e-08 0.31
5HT1A_HUMAN HTR1A 5-hydroxytryptamine receptor 1A 3.114e-08 0.37
OX1R_RAT Hcrtr1 Orexin receptor type 1 6.16e-08 0.33
SCN1A_HUMAN SCN1A Sodium channel protein type 1 subunit alpha 7.803e-08 0.30
FAK1_HUMAN PTK2 Focal adhesion kinase 1 1.194e-07 0.37
DRD3_RAT Drd3 D(3) dopamine receptor 1.956e-07 0.34
ALK_HUMAN ALK ALK tyrosine kinase receptor 2.156e-07 0.31
DRD2_HUMAN DRD2 D(2) dopamine receptor 3.061e-07 0.34
SSR2_RAT Sstr2 Somatostatin receptor type 2 3.54e-07 0.33
INSR_HUMAN INSR Insulin receptor 3.615e-07 0.30
NMDZ1_RAT Grin1 Glutamate receptor ionotropic, NMDA 1 5.559e-07 0.37
CCKAR_HUMAN CCKAR Cholecystokinin receptor type A 5.756e-07 0.29
SCN9A_MOUSE Scn9a Sodium channel protein type 9 subunit alpha 8.643e-07 0.30
DRD3_HUMAN DRD3 D(3) dopamine receptor 1.25e-06 0.35
Q5TKS5_STAAU fabI Enoyl-ACP reductase 1.898e-06 0.29
PRIO_SHEEP PRNP Major prion protein 2.14e-06 0.29
MC4R_HUMAN MC4R Melanocortin receptor 4 2.283e-06 0.34
PPARD_HUMAN PPARD Peroxisome proliferator-activated receptor delta 2.537e-06 0.32
5HT2A_RAT Htr2a 5-hydroxytryptamine receptor 2A 6.176e-06 0.34
LTC4S_HUMAN LTC4S Leukotriene C4 synthase 6.714e-06 0.32
Q0GMK6_RABIT CDK4 Cyclin-dependent kinase 4 7.581e-06 0.29
SCNAA_RAT Scn10a Sodium channel protein type 10 subunit alpha 8.143e-06 0.32
CCR2_HUMAN CCR2 C-C chemokine receptor type 2 9.972e-06 0.32

Fexinidazole

A3KMY8_BOVIN GUSB Beta-glucuronidase 1.046e-29 0.32
FABH_ECOLI fabH 3-oxoacyl-[acyl-carrier-protein] synthase 3 4.441e-16 0.29
ACRO_PIG ACR Acrosin 1.565e-14 0.30
C4LW95_ENTHI Thioredoxin reductase 2.481e-08 0.33
TYSY_HUMAN TYMS Thymidylate synthase 2.249e-07 0.36
C3TDZ2_ECOLX fabH 3-oxoacyl-[acyl-carrier-protein] synthase 3 2.886e-06 0.33
XDH_RAT Xdh Xanthine dehydrogenase/oxidase 5.429e-06 0.31
SKN1_CAEEL skn-1 Protein skinhead-1 9.413e-06 0.32

Sarecycline

MDFA_ECOLI mdfA Multidrug transporter MdfA 1.228e-26 0.34

Brincidofovir

PPAF_PHAVU Fe(3+)-Zn(2+) purple acid phosphatase 3.637e-25 0.31
A85C_MYCTU fbpC Diacylglycerol acyltransferase/mycolyltransferase Ag85C 4.832e-21 0.32
CP2E1_HUMAN CYP2E1 Cytochrome P450 2E1 2.776e-15 0.29
LPAR3_HUMAN LPAR3 Lysophosphatidic acid receptor 3 2.065e-14 0.36
PA2GD_HUMAN PLA2G2D Group IID secretory phospholipase A2 1.874e-13 0.32
RNAS1_BOVIN RNASE1 Ribonuclease pancreatic 1.4e-12 0.31
HPRT_HUMAN HPRT1 Hypoxanthine-guanine phosphoribosyltransferase 2.664e-12 0.31
PA2GC_HUMAN PLA2G2C Putative inactive group IIC secretory phospholipase A2 1.208e-10 0.31
DPOLB_HUMAN POLB DNA polymerase beta 1.437e-09 0.30
O39930_9HEPC NS5b RNA-directed RNA polymerase 4.315e-07 0.29
P2Y10_HUMAN P2RY10 Putative P2Y purinoceptor 10 4.813e-07 0.32
ADA_HUMAN ADA Adenosine deaminase 5.422e-07 0.32
AKT1_MOUSE Akt1 RAC-alpha serine/threonine-protein kinase 1.122e-06 0.28
LPAR1_HUMAN LPAR1 Lysophosphatidic acid receptor 1 2.164e-06 0.36
SIAT1_HUMAN ST6GAL1 Beta-galactoside alpha-2,6-sialyltransferase 1 3.082e-06 0.31
S1PR5_HUMAN S1PR5 Sphingosine 1-phosphate receptor 5 3.995e-06 0.30
S1PR4_HUMAN S1PR4 Sphingosine 1-phosphate receptor 4 4.711e-06 0.30
C3TDZ2_ECOLX fabH 3-oxoacyl-[acyl-carrier-protein] synthase 3 4.778e-06 0.32

Iomeprol

Q8X6S1_ECO57 nfsA Nitroreductase A 6.273e-20 0.35

Fostemsavir

SC6A7_HUMAN SLC6A7 Sodium-dependent proline transporter 1.155e-14 0.30
Q6QLK5_9HIV1 env Envelope glycoprotein gp160 2.085e-11 0.64
REV1_HUMAN REV1 DNA repair protein REV1 5.975e-08 0.30

Nifurtimox

MITF_HUMAN MITF Microphthalmia-associated transcription factor 2.909e-14 0.47
Q5A7N4_CANAL TPT1 tRNA 2'-phosphotransferase 6.557e-10 0.33
DDIT3_HUMAN DDIT3 DNA damage-inducible transcript 3 protein 2.947e-07 0.30
CISD1_HUMAN CISD1 CDGSH iron-sulfur domain-containing protein 1 3.26e-07 0.46

Vonoprazan

CP2A6_HUMAN CYP2A6 Cytochrome P450 2A6 2.339e-12 0.32
Q05BA5_MOUSE Ncoa3 Nuclear receptor coactivator 2.443e-12 0.30
PCKGC_RAT Pck1 Phosphoenolpyruvate carboxykinase, cytosolic [GTP] 8.149e-10 0.31
CRCM1_RAT Orai1 Calcium release-activated calcium channel protein 1 3.091e-09 0.31
GPBAR_HUMAN GPBAR1 G-protein coupled bile acid receptor 1 9.547e-08 0.37
STIM1_RAT Stim1 Stromal interaction molecule 1 1.395e-07 0.31
NAMPT_HUMAN NAMPT Nicotinamide phosphoribosyltransferase 1.534e-07 0.32
GPBAR_MOUSE Gpbar1 G-protein coupled bile acid receptor 1 4.42e-07 0.37
STIM1_HUMAN STIM1 Stromal interaction molecule 1 4.324e-06 0.31
PCKGC_HUMAN PCK1 Phosphoenolpyruvate carboxykinase, cytosolic [GTP] 6.544e-06 0.31
S40A1_HUMAN SLC40A1 Solute carrier family 40 member 1 8.444e-06 0.32

Voclosporin

NCOR1_HUMAN NCOR1 Nuclear receptor corepressor 1 4.654e-11 0.29

Galactose

LYAG_RAT Gaa Lysosomal alpha-glucosidase 1.019e-10 0.29
SUIS_RAT Si Sucrase-isomaltase, intestinal 4.018e-09 0.29
MGA_HUMAN MGAM Maltase-glucoamylase, intestinal 4.677e-08 0.29