Results of Job: search_cbae699a-7709-4cd0-8082-76451aa2690d

Query Target Key Target Name Description P-Value MaxTC

compound_1

NTR2_HUMAN NTSR2 Neurotensin receptor type 2 4.042e-211 0.61
HLAA_HUMAN HLA-A HLA class I histocompatibility antigen, A alpha chain 5.686e-200 0.66
DLG4_HUMAN DLG4 Disks large homolog 4 1.469e-141 0.44
CDYL2_HUMAN CDYL2 Chromodomain Y-like protein 2 1.934e-138 0.34
PCSK6_HUMAN PCSK6 Proprotein convertase subtilisin/kexin type 6 3.953e-138 0.59
PAR2_HUMAN F2RL1 Proteinase-activated receptor 2 6.343e-135 0.53
FURIN_HUMAN FURIN Furin 4.257e-132 0.59
NTR1_RAT Ntsr1 Neurotensin receptor type 1 4.36e-129 0.43
NTR1_HUMAN NTSR1 Neurotensin receptor type 1 4.862e-126 0.56
CBX7_HUMAN CBX7 Chromobox protein homolog 7 5.356e-122 0.41
NTR1_MOUSE Ntsr1 Neurotensin receptor type 1 2.349e-117 0.54
CBX4_HUMAN CBX4 E3 SUMO-protein ligase CBX4 4.282e-117 0.35
CAN2_HUMAN CAPN2 Calpain-2 catalytic subunit 4.672e-114 0.35
EDNRB_RAT Ednrb Endothelin receptor type B 7.629e-111 0.47
CBX8_HUMAN CBX8 Chromobox protein homolog 8 1.936e-107 0.34
CATB_BOVIN CTSB Cathepsin B 6.513e-99 0.48
KLK3_HUMAN KLK3 Prostate-specific antigen 7.743e-99 0.45
Q8I6Z5_PLAF7 Plasmepsin V 3.581e-98 0.38
ANPRC_HUMAN NPR3 Atrial natriuretic peptide receptor 3 2.686e-95 0.40
CD36_RAT Cd36 Platelet glycoprotein 4 1.403e-93 0.37
GSP_CRIFA GSP Glutathionylspermidine synthase 8.603e-90 0.51
RIR1_HHV11 RIR1 Ribonucleoside-diphosphate reductase large subunit 4.909e-89 0.37
AMPE_HUMAN ENPEP Glutamyl aminopeptidase 1.672e-81 0.46
MAGI3_HUMAN MAGI3 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 1.226e-79 0.39
SORT_HUMAN SORT1 Sortilin 4.27e-77 0.42
BXA1_CLOBH botA Botulinum neurotoxin type A 5.99e-77 0.49
EDNRA_MOUSE Ednra Endothelin-1 receptor 4.083e-69 0.43
ST14_MOUSE St14 Suppressor of tumorigenicity 14 protein homolog 6.564e-68 0.41
HGFA_HUMAN HGFAC Hepatocyte growth factor activator 4.593e-66 0.62
C3AR_HUMAN C3AR1 C3a anaphylatoxin chemotactic receptor 4.352e-65 0.54
CAN2_BOVIN CAPN2 Calpain-2 catalytic subunit 4.929e-61 0.35
Q6MGC4_RAT Pfdn6 H2-K region expressed gene 2, rat orthologue 1.034e-59 0.36
RIR1_MOUSE Rrm1 Ribonucleoside-diphosphate reductase large subunit 2.763e-58 0.38
POLG_WNV Genome polyprotein 1.037e-57 0.38
ECE1_RAT Ece1 Endothelin-converting enzyme 1 6.711e-57 0.35
LYAM3_MOUSE Selp P-selectin 7.496e-57 0.28
CAN1_HUMAN CAPN1 Calpain-1 catalytic subunit 1.835e-55 0.41
POLG_DEN26 Genome polyprotein 8.683e-55 0.36
EDNRA_PIG EDNRA Endothelin-1 receptor 2.891e-53 0.39
CATD_BOVIN CTSD Cathepsin D 1.013e-52 0.35
CFAB_HUMAN CFB Complement factor B 3.251e-52 0.46
PSB6_YEAST PRE7 Proteasome subunit beta type-6 3.751e-51 0.41
MYLK_CHICK Mylk Myosin light chain kinase, smooth muscle 1.715e-48 0.38
SPSB2_HUMAN SPSB2 SPRY domain-containing SOCS box protein 2 1.413e-47 0.40
SPLB_STAAU splB Serine protease SplB 1.572e-47 0.38
NK2R_MESAU TACR2 Substance-K receptor 2.35e-47 0.38
Q95WR6_LEIDO Cysteine protease 5.375e-47 0.29
Q9ERC0_RAT Npy2r Neuropeptide Y receptor Y2 6.346e-47 0.43
HEPS_HUMAN HPN Serine protease hepsin 6.567e-46 0.41
WDR5_HUMAN WDR5 WD repeat-containing protein 5 3.272e-45 0.43
CO2_HUMAN C2 Complement C2 3.546e-45 0.36
LYAM1_MOUSE Sell L-selectin 6.331e-45 0.28
PEPA_PIG PGA Pepsin A 5.574e-44 0.38
RENI1_MOUSE Ren1 Renin-1 9.712e-44 0.35
OPRX_MOUSE Oprl1 Nociceptin receptor 1.251e-43 0.34
A3EZI9_9HEPC NS3 Genome polyprotein 2.13e-43 0.47
CBX5_HUMAN CBX5 Chromobox protein homolog 5 2.2e-43 0.34
PAPA1_CARPA Papain 8.11e-43 0.43
PSB5_HUMAN PSMB5 Proteasome subunit beta type-5 4.382e-42 0.51
SURA_ECOLI surA Chaperone SurA 1.203e-41 0.33
VM1B1_BOTAS Snake venom metalloproteinase BaP1 1.231e-41 0.37
CBX2_HUMAN CBX2 Chromobox protein homolog 2 3.793e-41 0.33
CBX6_HUMAN CBX6 Chromobox protein homolog 6 3.793e-41 0.33
CDY1_HUMAN CDY1; CDY1B Testis-specific chromodomain protein Y 1 3.793e-41 0.33
CDYL_HUMAN CDYL Chromodomain Y-like protein 3.793e-41 0.33
THER_BACTH npr Thermolysin 2.184e-40 0.36
FOLH1_HUMAN FOLH1 Glutamate carboxypeptidase 2 2.728e-40 0.42
CPNS1_PIG CAPNS1 Calpain small subunit 1 2.757e-40 0.31
LCAP_RAT Lnpep Leucyl-cystinyl aminopeptidase 3.176e-40 0.36
ANPRA_HUMAN NPR1 Atrial natriuretic peptide receptor 1 9.635e-40 0.40
Q9I056_PSEAE cpg2 Carboxypeptidase G2 5.043e-39 0.31
OPRD_RAT Oprd1 Delta-type opioid receptor 5.575e-39 0.50
NEC1_HUMAN PCSK1 Neuroendocrine convertase 1 5.682e-39 0.30
PCSK5_HUMAN PCSK5 Proprotein convertase subtilisin/kexin type 5 5.682e-39 0.30
TPP2_HUMAN TPP2 Tripeptidyl-peptidase 2 5.748e-39 0.31
SIR1_HUMAN SIRT1 NAD-dependent protein deacetylase sirtuin-1 9.901e-39 0.50
TMPS6_HUMAN TMPRSS6 Transmembrane protease serine 6 7.281e-38 0.40
AMPB_MOUSE Rnpep Aminopeptidase B 1.443e-37 0.30
AMPL_BOVIN LAP3 Cytosol aminopeptidase 1.443e-37 0.30
ST14_HUMAN ST14 Suppressor of tumorigenicity 14 protein 2.634e-37 0.44
NMT_CANAL NMT1 Glycylpeptide N-tetradecanoyltransferase 1.495e-35 0.45
LYAM2_MOUSE Sele E-selectin 1.522e-35 0.28
S15A2_HUMAN SLC15A2 Solute carrier family 15 member 2 5.107e-35 0.44
EDNRA_HUMAN EDNRA Endothelin-1 receptor 6.007e-35 0.45
OPRK_MOUSE Oprk1 Kappa-type opioid receptor 1.104e-34 0.40
OPRD_MOUSE Oprd1 Delta-type opioid receptor 1.109e-34 0.48
Q4U254_9ENTO protease Protease 2.173e-34 0.52
GRPR_RAT Grpr Gastrin-releasing peptide receptor 5.92e-34 0.34
A4HSF7_LEIIN TRYR Trypanothione reductase 2.939e-33 0.41
LYAM1_HUMAN SELL L-selectin 3.348e-33 0.29
CASPE_HUMAN CASP14 Caspase-14 3.098e-32 0.40
OPRM_RAT Oprm1 Mu-type opioid receptor 8.203e-32 0.50
SSPA_STAAU sspA Glutamyl endopeptidase 1.723e-31 0.32
NK2R_RAT Tacr2 Substance-K receptor 2.182e-31 0.38
OPRM_CAVPO OPRM1 Mu-type opioid receptor 8.241e-30 0.40
SHC1_HUMAN SHC1 SHC-transforming protein 1 1.318e-29 0.29
CATB_HUMAN CTSB Cathepsin B 6.422e-29 0.43
NMBR_RAT Nmbr Neuromedin-B receptor 1.682e-28 0.35
NK1R_CAVPO TACR1 Substance-P receptor 1.78e-28 0.38
FPR1_HUMAN FPR1 fMet-Leu-Phe receptor 2.495e-28 0.41
HMDH_MESAU HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase 4.005e-28 0.45
NPFF2_RAT Npffr2 Neuropeptide FF receptor 2 5.101e-28 0.35
AMPB_RAT Rnpep Aminopeptidase B 1.219e-27 0.34
FOLH1_RAT Folh1 Glutamate carboxypeptidase 2 1.373e-27 0.44
CATE_HUMAN CTSE Cathepsin E 1.55e-27 0.31
NEP_MOUSE Mme Neprilysin 1.922e-26 0.31
CASPA_HUMAN CASP10 Caspase-10 1.944e-26 0.43
POLG_HCV1 Genome polyprotein 9.17e-26 0.44
CBPB2_HUMAN CPB2 Carboxypeptidase B2 1.604e-25 0.39
PSB5_YEAST PRE2 Proteasome subunit beta type-5 2.323e-25 0.41
NRP1_RAT Nrp1 Neuropilin-1 3.194e-24 0.32
CATD_HUMAN CTSD Cathepsin D 1.337e-23 0.49
STAT3_HUMAN STAT3 Signal transducer and activator of transcription 3 3.17e-23 0.45
GRB2_HUMAN GRB2 Growth factor receptor-bound protein 2 4.608e-23 0.45
CASP1_HUMAN CASP1 Caspase-1 6.23e-22 0.43
CASP9_HUMAN CASP9 Caspase-9 3.522e-21 0.43
EDNRB_PIG EDNRB Endothelin receptor type B 4.228e-21 0.35
PGTB1_BOVIN PGGT1B Geranylgeranyl transferase type-1 subunit beta 1.52e-20 0.43
MMP12_HUMAN MMP12 Macrophage metalloelastase 2.034e-20 0.37
O07911_STAAU agrC AgrC 2.892e-20 0.38
Q72874_9HIV1 pol Pol polyprotein 3.938e-20 0.56
PSB2_HUMAN PSMB2 Proteasome subunit beta type-2 9.194e-20 0.44
GNPAT_HUMAN GNPAT Dihydroxyacetone phosphate acyltransferase 9.314e-20 0.31
NK3R_RAT Tacr3 Neuromedin-K receptor 1.247e-19 0.38
MMP3_HUMAN MMP3 Stromelysin-1 1.434e-19 0.40
DSBA_ECOLI dsbA Thiol:disulfide interchange protein DsbA 3.589e-19 0.30
CARP_RHICH Rhizopuspepsin 5.75e-19 0.32
PEPC_HUMAN PGC Gastricsin 7.757e-19 0.29
LY96_HUMAN LY96 Lymphocyte antigen 96 1.369e-18 0.36
NK3R_CAVPO TACR3 Neuromedin-K receptor 2.757e-18 0.38
LYAM3_HUMAN SELP P-selectin 3.408e-18 0.29
GSTM1_HUMAN GSTM1 Glutathione S-transferase Mu 1 4.879e-18 0.29
NEC2_HUMAN PCSK2 Neuroendocrine convertase 2 7.502e-18 0.28
R1AB_SARS rep Replicase polyprotein 1ab 1.532e-17 0.52
D2K2A8_9HEPC NS4A Non-structural protein 4A 2.959e-17 0.47
NOD1_HUMAN NOD1 Nucleotide-binding oligomerization domain-containing protein 1 3.896e-17 0.38
S15A2_RAT Slc15a2 Solute carrier family 15 member 2 4.474e-17 0.30
LCAP_HUMAN LNPEP Leucyl-cystinyl aminopeptidase 4.633e-17 0.38
AMP1_PLAFQ M1 family aminopeptidase 1.11e-16 0.35
BMP1_HUMAN BMP1 Bone morphogenetic protein 1 1.11e-16 0.36
MMP10_HUMAN MMP10 Stromelysin-2 1.11e-16 0.37
QRFPR_HUMAN QRFPR Pyroglutamylated RF-amide peptide receptor 1.11e-16 0.37
AMPL_HUMAN LAP3 Cytosol aminopeptidase 2.22e-16 0.36
SSR2_HUMAN SSTR2 Somatostatin receptor type 2 2.22e-16 0.31
CCNA2_HUMAN CCNA2 Cyclin-A2 8.882e-16 0.53
AMPN_HUMAN ANPEP Aminopeptidase N 9.992e-16 0.40
ERAP2_HUMAN ERAP2 Endoplasmic reticulum aminopeptidase 2 1.332e-15 0.38
CAN2_PIG CAPN2 Calpain-2 catalytic subunit 1.443e-15 0.32
GHSR_HUMAN GHSR Growth hormone secretagogue receptor type 1 1.443e-15 0.46
NPY4R_HUMAN NPY4R Neuropeptide Y receptor type 4 2.22e-15 0.31
FNTA_BOVIN FNTA Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha 2.665e-15 0.43
ELAS_PSEAE lasB Elastase 2.887e-15 0.40
O90781_9PLVG HIV-1 protease HIV-1 protease 4.108e-15 0.48
Q91H74_9FLAV Genome polyprotein 5.107e-15 0.30
RIR1_HUMAN RRM1 Ribonucleoside-diphosphate reductase large subunit 8.771e-15 0.40
CATL1_HUMAN CTSL Cathepsin L1 1.11e-14 0.42
Q9YQ12_9HIV1 protease Protease 2.365e-14 0.48
FNTB_RAT Fntb Protein farnesyltransferase subunit beta 4.896e-14 0.38
FNTA_RAT Fnta Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha 6.273e-14 0.38
CAN1_PIG CAPN1 Calpain-1 catalytic subunit 7.994e-14 0.32
DRB3_HUMAN HLA-DRB3 HLA class II histocompatibility antigen, DR beta 3 chain 8.871e-14 0.38
KEAP1_HUMAN KEAP1 Kelch-like ECH-associated protein 1 1.052e-13 0.35
Q6UB75_PIG Group VII phospholipase A2 1.141e-13 0.30
HMDH_HUMAN HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1.389e-13 0.45
RENI_RAT Ren1 Renin 1.817e-13 0.31
PEPA5_HUMAN PGA5 Pepsin A-5 2.051e-13 0.30
PEPA1_PENJA Penicillopepsin-1 2.393e-13 0.29
CCND1_HUMAN CCND1 G1/S-specific cyclin-D1 2.812e-13 0.45
CASP4_HUMAN CASP4 Caspase-4 3.244e-13 0.43
ACE2_RAT Ace2 Angiotensin-converting enzyme 2 5.338e-13 0.28
PCSK7_HUMAN PCSK7 Proprotein convertase subtilisin/kexin type 7 5.338e-13 0.28
TM11D_HUMAN TMPRSS11D Transmembrane protease serine 11D 6.151e-13 0.43
FPRS1_MOUSE Fpr-s1 Formyl peptide receptor-related sequence 1 1.199e-12 0.52
BACE1_HUMAN BACE1 Beta-secretase 1 1.312e-12 0.62
UBC9_HUMAN UBE2I SUMO-conjugating enzyme UBC9 1.397e-12 0.54
CATK_HUMAN CTSK Cathepsin K 1.769e-12 0.43
NEP_RABIT MME Neprilysin 2.28e-12 0.46
SIR2_HUMAN SIRT2 NAD-dependent protein deacetylase sirtuin-2 2.314e-12 0.47
AMPX_VIBPR Bacterial leucyl aminopeptidase 3.497e-12 0.30
PLMN_BOVIN PLG Plasminogen 4.33e-12 0.29
AMPN_PIG ANPEP Aminopeptidase N 8.229e-12 0.46
NALD2_HUMAN NAALAD2 N-acetylated-alpha-linked acidic dipeptidase 2 1.096e-11 0.32
O68720_YERPE yopH Targeted effector protein 2.661e-11 0.31
GRPR_HUMAN GRPR Gastrin-releasing peptide receptor 3.879e-11 0.35
NK1R_RAT Tacr1 Substance-P receptor 3.894e-11 0.38
DPO1_THEAQ polA DNA polymerase I, thermostable 4.121e-11 0.29
AMPN_MOUSE Anpep Aminopeptidase N 4.393e-11 0.30
PRSS8_HUMAN PRSS8 Prostasin 5.254e-11 0.34
AMPB_HUMAN RNPEP Aminopeptidase B 6.023e-11 0.29
RENI_HUMAN REN Renin 7.122e-11 0.38
SIR5_HUMAN SIRT5 NAD-dependent protein deacylase sirtuin-5, mitochondrial 7.472e-11 0.31
AMD_RAT Pam Peptidylglycine alpha-amidating monooxygenase 7.93e-11 0.31
ACE_RAT Ace Angiotensin-converting enzyme 1.069e-10 0.46
MCA2_TRYBB MCA2 Metacaspase 2.458e-10 0.30
CHIA_SERMA chiA Chitinase A 2.923e-10 0.30
Q9NAW4_PLAFA Cysteine protease falcipain-3 3.866e-10 0.29
PSB1_HUMAN PSMB1 Proteasome subunit beta type-1 4.023e-10 0.44
NMUR1_HUMAN NMUR1 Neuromedin-U receptor 1 4.084e-10 0.29
PA2G5_HUMAN PLA2G5 Calcium-dependent phospholipase A2 6.194e-10 0.28
MMP8_HUMAN MMP8 Neutrophil collagenase 6.849e-10 0.37
Q95PM0_TRYBR rhodesain Cysteine protease 1.096e-09 0.34
MMP1_HUMAN MMP1 Interstitial collagenase 1.174e-09 0.39
ENTK_HUMAN TMPRSS15 Enteropeptidase 1.401e-09 0.33
CASP8_HUMAN CASP8 Caspase-8 1.598e-09 0.43
ERAP1_HUMAN ERAP1 Endoplasmic reticulum aminopeptidase 1 1.785e-09 0.38
NMUR2_HUMAN NMUR2 Neuromedin-U receptor 2 2.039e-09 0.29
CARP2_CANAX SAP2 Candidapepsin-2 2.15e-09 0.29
OPRX_HUMAN OPRL1 Nociceptin receptor 2.156e-09 0.48
SRC_HUMAN SRC Proto-oncogene tyrosine-protein kinase Src 2.435e-09 0.51
PTPRC_HUMAN PTPRC Receptor-type tyrosine-protein phosphatase C 3.667e-09 0.42
ACE_HUMAN ACE Angiotensin-converting enzyme 3.813e-09 0.40
AMD_HUMAN PAM Peptidyl-glycine alpha-amidating monooxygenase 4.608e-09 0.28
MMP2_HUMAN MMP2 72 kDa type IV collagenase 4.839e-09 0.40
PLM2_PLAFA Plasmepsin-2 1.269e-08 0.39
CTRL_HUMAN CTRL Chymotrypsin-like protease CTRL-1 1.607e-08 0.28
CATG_HUMAN CTSG Cathepsin G 2.375e-08 0.37
XIAP_HUMAN XIAP E3 ubiquitin-protein ligase XIAP 2.889e-08 0.58
ADCY5_HUMAN ADCY5 Adenylate cyclase type 5 3.201e-08 0.36
CYSK_MYCTU cysK1 O-acetylserine sulfhydrylase 5.625e-08 0.36
LYAM2_HUMAN SELE E-selectin 7.529e-08 0.29
SPP2A_HUMAN SPPL2A Signal peptide peptidase-like 2A 1.185e-07 0.30
CASP5_HUMAN CASP5 Caspase-5 1.217e-07 0.38
ACE_MOUSE Ace Angiotensin-converting enzyme 1.377e-07 0.31
LEP_ECOLI lepB Signal peptidase I 1.462e-07 0.29
CPNS1_HUMAN CAPNS1 Calpain small subunit 1 1.475e-07 0.35
Q17SB2_PLAFA Plasmepsin 4 1.576e-07 0.29
MMP17_HUMAN MMP17 Matrix metalloproteinase-17 2.483e-07 0.35
PSA_HUMAN NPEPPS Puromycin-sensitive aminopeptidase 2.729e-07 0.30
PA2G5_MOUSE Pla2g5 Calcium-dependent phospholipase A2 2.925e-07 0.28
PLM1_PLAFA Plasmepsin-1 3.035e-07 0.39
BKRB1_RAT Bdkrb1 B1 bradykinin receptor 4.106e-07 0.36
PSA1_HUMAN PSMA1 Proteasome subunit alpha type-1 4.947e-07 0.44
PSA2_HUMAN PSMA2 Proteasome subunit alpha type-2 4.947e-07 0.44
PSA3_HUMAN PSMA3 Proteasome subunit alpha type-3 4.947e-07 0.44
PSA4_HUMAN PSMA4 Proteasome subunit alpha type-4 4.947e-07 0.44
PSA5_HUMAN PSMA5 Proteasome subunit alpha type-5 4.947e-07 0.44
PSA6_HUMAN PSMA6 Proteasome subunit alpha type-6 4.947e-07 0.44
PSA7_HUMAN PSMA7 Proteasome subunit alpha type-7 4.947e-07 0.44
PSB11_HUMAN PSMB11 Proteasome subunit beta type-11 4.947e-07 0.44
PSB3_HUMAN PSMB3 Proteasome subunit beta type-3 4.947e-07 0.44
PSB4_HUMAN PSMB4 Proteasome subunit beta type-4 4.947e-07 0.44
PSB6_HUMAN PSMB6 Proteasome subunit beta type-6 4.947e-07 0.44
PSB7_HUMAN PSMB7 Proteasome subunit beta type-7 4.947e-07 0.44
PSMA8_HUMAN PSMA8 Proteasome subunit alpha-type 8 4.947e-07 0.44
OPRD_HUMAN OPRD1 Delta-type opioid receptor 5.039e-07 0.41
PSB10_HUMAN PSMB10 Proteasome subunit beta type-10 8.108e-07 0.44
OPRK_CAVPO OPRK1 Kappa-type opioid receptor 9.347e-07 0.43
PA2GA_MOUSE Pla2g2a Phospholipase A2, membrane associated 1.142e-06 0.28
CASP1_MOUSE Casp1 Caspase-1 1.585e-06 0.37
FNTB_BOVIN FNTB Protein farnesyltransferase subunit beta 1.622e-06 0.35
CASP3_HUMAN CASP3 Caspase-3 1.93e-06 0.43
MRP2_RAT Abcc2 Canalicular multispecific organic anion transporter 1 1.944e-06 0.28
PAR1_HUMAN F2R Proteinase-activated receptor 1 2.007e-06 0.37
GNRHR_RAT Gnrhr Gonadotropin-releasing hormone receptor 2.098e-06 0.44
OPRM_MOUSE Oprm1 Mu-type opioid receptor 2.919e-06 0.35
FA11_HUMAN F11 Coagulation factor XI 3.511e-06 0.35
NEP_HUMAN MME Neprilysin 4.1e-06 0.36
GRAB_HUMAN GZMB Granzyme B 4.556e-06 0.31
CTRC_HUMAN CTRC Chymotrypsin-C 4.66e-06 0.33
NK2R_RABIT TACR2 Substance-K receptor 5.095e-06 0.28
PSB9_HUMAN PSMB9 Proteasome subunit beta type-9 8.118e-06 0.44
NPFF1_HUMAN NPFFR1 Neuropeptide FF receptor 1 8.803e-06 0.40
OPRK_HUMAN OPRK1 Kappa-type opioid receptor 8.874e-06 0.48