Results of Job: search_e8067da1-5279-4cac-848f-8822f8bdc58f

Query Target Key Target Name Description P-Value MaxTC

Canagliflozin

SC5A2_HUMAN SLC5A2 Sodium/glucose cotransporter 2 0 1.00
SC5A1_HUMAN SLC5A1 Sodium/glucose cotransporter 1 6.25e-92 1.00
Q9YQ12_9HIV1 protease Protease 0.116 1.00
FIMH_ECOLI fimH Type 1 fimbrin D-mannose specific adhesin 3.267e-65 0.38
SC5A2_MOUSE Slc5a2 Sodium/glucose cotransporter 2 4.294e-52 0.50
SC5A4_HUMAN SLC5A4 Solute carrier family 5 member 4 4.075e-37 0.42
SC5AB_HUMAN SLC5A11 Sodium/myo-inositol cotransporter 2 7.94e-34 0.42
SC5A1_RAT Slc5a1 Sodium/glucose cotransporter 1 7.53e-31 0.34
PYGM_RABIT PYGM Glycogen phosphorylase, muscle form 5.728e-28 0.40
SC5A2_RAT Slc5a2 Sodium/glucose cotransporter 2 4.26e-27 0.42
Q9QXI6_MOUSE Slc5a1 SGLT1 protein 2.29e-22 0.50
B4EH87_BURCJ Lectin 1.11e-16 0.32
ADK_TOXGO AK Adenosine kinase 2.109e-15 0.30
AA1R_CHICK ADORA1 Adenosine receptor A1 1.243e-14 0.31
ADOK_MYCTO adoK Adenosine kinase 3.114e-11 0.33
LEG1_HUMAN LGALS1 Galectin-1 2.957e-10 0.30
TYRO_HUMAN TYR Tyrosinase 3.304e-09 0.30
LEG3_HUMAN LGALS3 Galectin-3 3.238e-08 0.30
S29A1_HUMAN SLC29A1 Equilibrative nucleoside transporter 1 8.601e-06 0.29

Afatinib

EGFR_HUMAN EGFR Epidermal growth factor receptor 7.942e-312 1.00
ERBB2_HUMAN ERBB2 Receptor tyrosine-protein kinase erbB-2 9.921e-224 1.00
ERBB4_HUMAN ERBB4 Receptor tyrosine-protein kinase erbB-4 5.62e-160 1.00
ERBB3_HUMAN ERBB3 Receptor tyrosine-protein kinase erbB-3 2.563e-50 1.00
SBK1_HUMAN SBK1 Serine/threonine-protein kinase SBK1 3.34e-34 1.00
PHKG1_HUMAN PHKG1 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 1.121e-32 1.00
CTRO_HUMAN CIT Citron Rho-interacting kinase 2.214e-32 1.00
STK10_HUMAN STK10 Serine/threonine-protein kinase 10 3.556e-32 1.00
EPHA6_HUMAN EPHA6 Ephrin type-A receptor 6 1.146e-30 1.00
MP2K5_HUMAN MAP2K5 Dual specificity mitogen-activated protein kinase kinase 5 9.457e-28 1.00
EPHB6_HUMAN EPHB6 Ephrin type-B receptor 6 1.314e-26 1.00
TXK_HUMAN TXK Tyrosine-protein kinase TXK 2.45e-26 1.00
RIPK2_HUMAN RIPK2 Receptor-interacting serine/threonine-protein kinase 2 6.755e-21 1.00
GAK_HUMAN GAK Cyclin-G-associated kinase 1.62e-20 1.00
SRC_HUMAN SRC Proto-oncogene tyrosine-protein kinase Src 2.937e-19 1.00
MKNK2_HUMAN MKNK2 MAP kinase-interacting serine/threonine-protein kinase 2 6.08e-18 1.00
KS6A6_HUMAN RPS6KA6 Ribosomal protein S6 kinase alpha-6 8.185e-18 1.00
MKNK1_HUMAN MKNK1 MAP kinase-interacting serine/threonine-protein kinase 1 4.219e-15 1.00
PHKG2_HUMAN PHKG2 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 3.683e-12 1.00
BLK_HUMAN BLK Tyrosine-protein kinase Blk 2.852e-10 1.00
SLK_HUMAN SLK STE20-like serine/threonine-protein kinase 8.945e-10 1.00
FRK_HUMAN FRK Tyrosine-protein kinase FRK 1.468e-09 1.00
ABL1_HUMAN ABL1 Tyrosine-protein kinase ABL1 9.506e-09 1.00
LCK_HUMAN LCK Tyrosine-protein kinase Lck 9.704e-09 1.00
INSR_HUMAN INSR Insulin receptor 1.272e-08 1.00
ST17A_HUMAN STK17A Serine/threonine-protein kinase 17A 2.065e-08 1.00
KC1E_HUMAN CSNK1E Casein kinase I isoform epsilon 4.461e-08 1.00
HCK_HUMAN HCK Tyrosine-protein kinase HCK 5.438e-08 1.00
DYR1B_HUMAN DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B 4.582e-07 1.00
IRAK1_HUMAN IRAK1 Interleukin-1 receptor-associated kinase 1 5.464e-07 1.00
HIPK4_HUMAN HIPK4 Homeodomain-interacting protein kinase 4 5.537e-07 1.00
UFO_HUMAN AXL Tyrosine-protein kinase receptor UFO 5.681e-07 1.00
DYRK2_HUMAN DYRK2 Dual specificity tyrosine-phosphorylation-regulated kinase 2 4.739e-06 1.00
DYR1A_HUMAN DYRK1A Dual specificity tyrosine-phosphorylation-regulated kinase 1A 1.674e-05 1.00
FLT3_HUMAN FLT3 Receptor-type tyrosine-protein kinase FLT3 3.479e-05 1.00
MK10_HUMAN MAPK10 Mitogen-activated protein kinase 10 0.0004756 1.00
MK14_HUMAN MAPK14 Mitogen-activated protein kinase 14 0.0005878 1.00
MK09_HUMAN MAPK9 Mitogen-activated protein kinase 9 0.00136 1.00
MET_HUMAN MET Hepatocyte growth factor receptor 0.0325 1.00
IGF1R_HUMAN IGF1R Insulin-like growth factor 1 receptor 0.2151 1.00
EPHA2_HUMAN EPHA2 Ephrin type-A receptor 2 3.4e-244 0.52
EPHB4_HUMAN EPHB4 Ephrin type-B receptor 4 3.732e-196 0.54
VGFR2_HUMAN KDR Vascular endothelial growth factor receptor 2 2.076e-100 0.76
DUS2L_HUMAN DUS2 tRNA-dihydrouridine(20) synthase [NAD(P)+]-like 1.327e-71 0.57
TBA1A_RAT Tuba1a Tubulin alpha-1A chain 6.653e-60 0.54
ULK3_MOUSE Ulk3 Serine/threonine-protein kinase ULK3 3.172e-49 0.54
ERBB2_RAT Erbb2 Receptor tyrosine-protein kinase erbB-2 8.818e-48 0.31
F16P1_PIG FBP1 Fructose-1,6-bisphosphatase 1 1.248e-47 0.46
VGFR1_HUMAN FLT1 Vascular endothelial growth factor receptor 1 1.221e-42 0.40
Q53I59_TRYCR PDEC Phosphodiesterase 8.107e-41 0.34
RET_HUMAN RET Proto-oncogene tyrosine-protein kinase receptor Ret 8.383e-38 0.69
MELK_HUMAN MELK Maternal embryonic leucine zipper kinase 1.804e-34 0.42
MK04_HUMAN MAPK4 Mitogen-activated protein kinase 4 3.397e-32 0.44
BRAF_HUMAN BRAF Serine/threonine-protein kinase B-raf 2.619e-29 0.45
ST32B_HUMAN STK32B Serine/threonine-protein kinase 32B 5.015e-27 0.54
STK36_HUMAN STK36 Serine/threonine-protein kinase 36 8.972e-27 0.54
COQ8B_HUMAN COQ8B Atypical kinase COQ8B, mitochondrial 1.053e-25 0.54
STK3_MOUSE Stk3 Serine/threonine-protein kinase 3 5.472e-24 0.54
M3K4_HUMAN MAP3K4 Mitogen-activated protein kinase kinase kinase 4 1.448e-23 0.54
CSK_HUMAN CSK Tyrosine-protein kinase CSK 1.742e-23 0.54
EPHA5_HUMAN EPHA5 Ephrin type-A receptor 5 3.263e-22 0.54
MK06_HUMAN MAPK6 Mitogen-activated protein kinase 6 2.397e-21 0.44
AUKBA_XENLA aurkb-a Aurora kinase B-A 2.714e-21 0.34
EPHA8_HUMAN EPHA8 Ephrin type-A receptor 8 2.744e-21 0.54
SIK2_HUMAN SIK2 Serine/threonine-protein kinase SIK2 4.194e-21 0.54
WEE2_HUMAN WEE2 Wee1-like protein kinase 2 6.928e-21 0.54
DMPK_HUMAN DMPK Myotonin-protein kinase 9.383e-20 0.54
EPHB1_HUMAN EPHB1 Ephrin type-B receptor 1 2.357e-19 0.54
STK24_HUMAN STK24 Serine/threonine-protein kinase 24 2.707e-19 0.54
MYLK2_HUMAN MYLK2 Myosin light chain kinase 2, skeletal/cardiac muscle 2.872e-19 0.54
E2AK3_HUMAN EIF2AK3 Eukaryotic translation initiation factor 2-alpha kinase 3 7.748e-19 0.35
NUAK2_HUMAN NUAK2 NUAK family SNF1-like kinase 2 3.072e-18 0.54
TIE1_HUMAN TIE1 Tyrosine-protein kinase receptor Tie-1 7.113e-18 0.54
M4K3_HUMAN MAP4K3 Mitogen-activated protein kinase kinase kinase kinase 3 1.11e-16 0.54
M3K3_HUMAN MAP3K3 Mitogen-activated protein kinase kinase kinase 3 2.22e-16 0.44
M4K1_HUMAN MAP4K1 Mitogen-activated protein kinase kinase kinase kinase 1 5.551e-16 0.54
STK25_HUMAN STK25 Serine/threonine-protein kinase 25 5.551e-16 0.54
FGR_HUMAN FGR Tyrosine-protein kinase Fgr 1.221e-15 0.54
PMYT1_HUMAN PKMYT1 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase 1.443e-15 0.54
EPHA3_HUMAN EPHA3 Ephrin type-A receptor 3 1.665e-15 0.54
ST38L_HUMAN STK38L Serine/threonine-protein kinase 38-like 1.665e-15 0.54
NEK3_HUMAN NEK3 Serine/threonine-protein kinase Nek3 2.442e-15 0.42
ABL2_HUMAN ABL2 Tyrosine-protein kinase ABL2 2.554e-15 0.54
COQ8A_HUMAN COQ8A Atypical kinase COQ8A, mitochondrial 2.776e-15 0.31
M3K2_HUMAN MAP3K2 Mitogen-activated protein kinase kinase kinase 2 8.216e-15 0.44
DCLK3_HUMAN DCLK3 Serine/threonine-protein kinase DCLK3 1.055e-14 0.54
MRCKG_HUMAN CDC42BPG Serine/threonine-protein kinase MRCK gamma 1.532e-14 0.31
AURKA_HUMAN AURKA Aurora kinase A 2.609e-14 0.46
STK4_HUMAN STK4 Serine/threonine-protein kinase 4 4.374e-14 0.54
LYN_HUMAN LYN Tyrosine-protein kinase Lyn 6.284e-14 0.54
EGFR_MOUSE Egfr Epidermal growth factor receptor 1.308e-13 0.29
M3K19_HUMAN MAP3K19 Mitogen-activated protein kinase kinase kinase 19 2.81e-13 0.44
KC1AL_HUMAN CSNK1A1L Casein kinase I isoform alpha-like 3.63e-13 0.54
PGFRB_HUMAN PDGFRB Platelet-derived growth factor receptor beta 4.21e-13 0.61
C3SLB7_ECOLX glmU Bifunctional protein GlmU 1.059e-12 0.33
STK35_HUMAN STK35 Serine/threonine-protein kinase 35 1.139e-12 0.42
AURKB_HUMAN AURKB Aurora kinase B 1.29e-12 0.46
GP119_MOUSE Gpr119 Glucose-dependent insulinotropic receptor 1.399e-12 0.31
E2AK4_HUMAN EIF2AK4 eIF-2-alpha kinase GCN2 2.167e-12 0.54
ST17B_HUMAN STK17B Serine/threonine-protein kinase 17B 4.677e-12 0.54
CDK16_HUMAN CDK16 Cyclin-dependent kinase 16 4.959e-12 0.54
RAF1_HUMAN RAF1 RAF proto-oncogene serine/threonine-protein kinase 5.623e-12 0.41
RIPK4_HUMAN RIPK4 Receptor-interacting serine/threonine-protein kinase 4 7.098e-12 0.31
STK33_HUMAN STK33 Serine/threonine-protein kinase 33 9.424e-12 0.54
EPHB2_HUMAN EPHB2 Ephrin type-B receptor 2 1.015e-11 0.36
JAK3_HUMAN JAK3 Tyrosine-protein kinase JAK3 1.578e-11 0.65
BMP2K_HUMAN BMP2K BMP-2-inducible protein kinase 1.805e-11 0.54
YES_HUMAN YES1 Tyrosine-protein kinase Yes 3.315e-11 0.54
MAST1_HUMAN MAST1 Microtubule-associated serine/threonine-protein kinase 1 5.425e-11 0.42
FYN_HUMAN FYN Tyrosine-protein kinase Fyn 6.791e-11 0.54
VGFR3_HUMAN FLT4 Vascular endothelial growth factor receptor 3 7.069e-11 0.46
FGFR1_HUMAN FGFR1 Fibroblast growth factor receptor 1 1.185e-10 0.38
M3K8_HUMAN MAP3K8 Mitogen-activated protein kinase kinase kinase 8 1.286e-10 0.30
PDE4D_HUMAN PDE4D cAMP-specific 3',5'-cyclic phosphodiesterase 4D 2.83e-10 0.34
SIK1_HUMAN SIK1 Serine/threonine-protein kinase SIK1 3.088e-10 0.42
PI42B_HUMAN PIP4K2B Phosphatidylinositol 5-phosphate 4-kinase type-2 beta 4.359e-10 0.54
ULK3_HUMAN ULK3 Serine/threonine-protein kinase ULK3 6.113e-10 0.31
CLK3_HUMAN CLK3 Dual specificity protein kinase CLK3 7.711e-10 0.54
EPHA1_HUMAN EPHA1 Ephrin type-A receptor 1 1.426e-09 0.44
TNIK_HUMAN TNIK TRAF2 and NCK-interacting protein kinase 1.527e-09 0.54
MARK1_HUMAN MARK1 Serine/threonine-protein kinase MARK1 1.634e-09 0.54
SRC_CHICK SRC Proto-oncogene tyrosine-protein kinase Src 2.26e-09 0.46
AAK1_HUMAN AAK1 AP2-associated protein kinase 1 2.336e-09 0.54
CD38_MOUSE Cd38 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 3.024e-09 0.36
T23O_HUMAN TDO2 Tryptophan 2,3-dioxygenase 3.948e-09 0.31
HDAC6_HUMAN HDAC6 Histone deacetylase 6 3.995e-09 0.46
ABCG2_HUMAN ABCG2 Broad substrate specificity ATP-binding cassette transporter ABCG2 4.156e-09 0.44
F16P1_HUMAN FBP1 Fructose-1,6-bisphosphatase 1 4.247e-09 0.46
EPHA7_HUMAN EPHA7 Ephrin type-A receptor 7 4.85e-09 0.31
KKCC1_HUMAN CAMKK1 Calcium/calmodulin-dependent protein kinase kinase 1 5.099e-09 0.54
PI42C_HUMAN PIP4K2C Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma 5.94e-09 0.44
HDAC3_HUMAN HDAC3 Histone deacetylase 3 6.578e-09 0.46
TIE2_HUMAN TEK Angiopoietin-1 receptor 7.211e-09 0.54
PAK6_HUMAN PAK6 Serine/threonine-protein kinase PAK 6 1.402e-08 0.42
INSRR_HUMAN INSRR Insulin receptor-related protein 2.654e-08 0.42
SMN_HUMAN SMN1; SMN2 Survival motor neuron protein 2.81e-08 0.28
CD38_HUMAN CD38 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 3.741e-08 0.36
DUSTY_HUMAN DSTYK Dual serine/threonine and tyrosine protein kinase 4.764e-08 0.42
MP2K2_HUMAN MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 4.835e-08 0.54
P2RX3_HUMAN P2RX3 P2X purinoceptor 3 5.317e-08 0.36
MRCKB_HUMAN CDC42BPB Serine/threonine-protein kinase MRCK beta 6.499e-08 0.31
ST32A_HUMAN STK32A Serine/threonine-protein kinase 32A 6.499e-08 0.31
M3K13_HUMAN MAP3K13 Mitogen-activated protein kinase kinase kinase 13 8.168e-08 0.42
TNI3K_HUMAN TNNI3K Serine/threonine-protein kinase TNNI3K 9.032e-08 0.54
KS6A4_HUMAN RPS6KA4 Ribosomal protein S6 kinase alpha-4 1.083e-07 0.44
SIK3_HUMAN SIK3 Serine/threonine-protein kinase SIK3 1.435e-07 0.31
MALT1_HUMAN MALT1 Mucosa-associated lymphoid tissue lymphoma translocation protein 1 2.267e-07 0.28
HUNK_HUMAN HUNK Hormonally up-regulated neu tumor-associated kinase 2.901e-07 0.31
HDAC1_HUMAN HDAC1 Histone deacetylase 1 2.944e-07 0.46
IRAK3_HUMAN IRAK3 Interleukin-1 receptor-associated kinase 3 5.241e-07 0.44
KCC1D_HUMAN CAMK1D Calcium/calmodulin-dependent protein kinase type 1D 5.44e-07 0.54
BTK_HUMAN BTK Tyrosine-protein kinase BTK 6.233e-07 0.54
MCHR2_HUMAN MCHR2 Melanin-concentrating hormone receptor 2 7.264e-07 0.30
E2AK2_HUMAN EIF2AK2 Interferon-induced, double-stranded RNA-activated protein kinase 7.325e-07 0.54
CSK21_HUMAN CSNK2A1 Casein kinase II subunit alpha 7.638e-07 0.33
CSF1R_HUMAN CSF1R Macrophage colony-stimulating factor 1 receptor 1.146e-06 0.54
FES_HUMAN FES Tyrosine-protein kinase Fes/Fps 1.294e-06 0.54
P3C2G_HUMAN PIK3C2G Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma 1.449e-06 0.30
P3C2B_HUMAN PIK3C2B Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta 1.842e-06 0.31
FGFR4_HUMAN FGFR4 Fibroblast growth factor receptor 4 1.925e-06 0.31
PLK1_HUMAN PLK1 Serine/threonine-protein kinase PLK1 2.71e-06 0.39
TESK1_HUMAN TESK1 Dual specificity testis-specific protein kinase 1 4.01e-06 0.31
NLK_HUMAN NLK Serine/threonine-protein kinase NLK 4.218e-06 0.44
LTK_HUMAN LTK Leukocyte tyrosine kinase receptor 4.427e-06 0.44
PAK2_HUMAN PAK2 Serine/threonine-protein kinase PAK 2 7.499e-06 0.42
STK26_HUMAN STK26 Serine/threonine-protein kinase 26 7.499e-06 0.42

Aminopterin

DYR_MOUSE Dhfr Dihydrofolate reductase 2.161e-307 1.00
DYR_LACCA folA Dihydrofolate reductase 6.07e-139 1.00
DYR_HUMAN DHFR Dihydrofolate reductase 3.812e-132 1.00
SO1A3_RAT Slco1a3 Solute carrier organic anion transporter family member 1A3 9.032e-112 1.00
B0BL08_ECOLX dfrA17 Dihydrofolate reductase 5.386e-34 1.00
PUR2_HUMAN GART Trifunctional purine biosynthetic protein adenosine-3 7.404e-192 0.51
DYR_ENTFC folA Dihydrofolate reductase 1.119e-175 0.71
TYSY_MOUSE Tyms Thymidylate synthase 7.167e-150 0.62
FOLC_HUMAN FPGS Folylpolyglutamate synthase, mitochondrial 6.23e-136 0.71
FOLC_MOUSE Fpgs Folylpolyglutamate synthase, mitochondrial 2.895e-129 0.82
S19A1_HUMAN SLC19A1 Reduced folate transporter 1.212e-125 0.71
PUR2_MOUSE Gart Trifunctional purine biosynthetic protein adenosine-3 1.185e-122 0.51
FOLR1_HUMAN FOLR1 Folate receptor alpha 7.499e-122 0.71
PCFT_HUMAN SLC46A1 Proton-coupled folate transporter 6.369e-119 0.71
FOLR2_HUMAN FOLR2 Folate receptor beta 5.638e-112 0.71
TYSY_HUMAN TYMS Thymidylate synthase 1.532e-101 0.71
DYR_RAT Dhfr Dihydrofolate reductase 8.238e-88 0.75
METH_HUMAN MTR Methionine synthase 1.964e-74 0.42
PTR1_LEIMA PTR1 Pteridine reductase 1 2.998e-72 0.71
DYR_PNECA Dihydrofolate reductase 1.046e-70 0.71
E2QDN0_ECOLX thyA Thymidylate synthase 2.355e-69 0.49
DRTS_TOXGO Bifunctional dihydrofolate reductase-thymidylate synthase 5.335e-69 0.71
TYSY_RAT Tyms Thymidylate synthase 1.069e-66 0.45
O30463_MYCAV folA Dihydrofolate reductase 6.423e-64 0.47
DYR_MYCTU folA Dihydrofolate reductase 3.545e-63 0.71
TYSY_LACCA thyA Thymidylate synthase 2.623e-62 0.58
FOLC_ECOLI folC Dihydrofolate synthase/folylpolyglutamate synthase 5.941e-61 0.49
Q9I056_PSEAE cpg2 Carboxypeptidase G2 1.123e-57 0.35
Q81VW8_BACAN folP Dihydropteroate synthase 1.293e-56 0.35
HMGB1_HUMAN HMGB1 High mobility group protein B1 2.286e-56 0.71
FOLH1_RAT Folh1 Glutamate carboxypeptidase 2 8.21e-56 0.58
NALD2_HUMAN NAALAD2 N-acetylated-alpha-linked acidic dipeptidase 2 3.735e-50 0.32
GGH_HUMAN GGH Gamma-glutamyl hydrolase 5.681e-49 0.32
DYR_YEAST DFR1 Dihydrofolate reductase 5.041e-47 0.44
MTDC_HUMAN MTHFD2 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial 2.027e-46 0.37
FOLH1_HUMAN FOLH1 Glutamate carboxypeptidase 2 1.558e-40 0.36
DYR_CHICK DHFR Dihydrofolate reductase 3.175e-39 0.71
DRTS_TRYCR Bifunctional dihydrofolate reductase-thymidylate synthase 3.516e-35 0.32
C3SWJ7_ECOLX thyA Thymidylate synthase 1.524e-31 0.71
GASR_RAT Cckbr Gastrin/cholecystokinin type B receptor 1.741e-27 0.36
HPGDS_MOUSE Hpgds Hematopoietic prostaglandin D synthase 2.728e-24 0.30
PUR9_HUMAN ATIC Bifunctional purine biosynthesis protein PURH 1.675e-23 0.59
DYR_ECOLI folA Dihydrofolate reductase 1.867e-22 0.36
DYR_BOVIN DHFR Dihydrofolate reductase 3.268e-22 0.71
P2Y12_HUMAN P2RY12 P2Y purinoceptor 12 1.429e-20 0.33
DRTS_LEIMA Bifunctional dihydrofolate reductase-thymidylate synthase 3.434e-19 0.71
Q81R22_BACAN dfrA Dihydrofolate reductase 7.608e-19 0.71
LY96_HUMAN LY96 Lymphocyte antigen 96 4.441e-16 0.31
GLUC_HUMAN GCG Glucagon 2.283e-12 0.31
CAH4_BOVIN CA4 Carbonic anhydrase 4 4.909e-10 0.45
FNTB_BOVIN FNTB Protein farnesyltransferase subunit beta 5.43e-08 0.29
FNTB_HUMAN FNTB Protein farnesyltransferase subunit beta 7.149e-08 0.41
CAH2_HUMAN CA2 Carbonic anhydrase 2 7.35e-08 0.56
TYSY_ECOLI thyA Thymidylate synthase 1.022e-07 0.36
FNTA_HUMAN FNTA Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha 2.222e-07 0.41
Q27552_CRYPV DHFR-TS Bifunctional dihydrofolate reductase-thymidylate synthase 6.234e-07 0.40
FNTA_BOVIN FNTA Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha 1.033e-06 0.29
CCKAR_RAT Cckar Cholecystokinin receptor type A 2.361e-06 0.35
CAH1_HUMAN CA1 Carbonic anhydrase 1 2.555e-06 0.56
NCOA3_HUMAN NCOA3 Nuclear receptor coactivator 3 4.805e-06 0.71
CP26A_HUMAN CYP26A1 Cytochrome P450 26A1 7.801e-06 0.30
AMD_RAT Pam Peptidylglycine alpha-amidating monooxygenase 7.965e-06 0.30
GSHR_HUMAN GSR Glutathione reductase, mitochondrial 9.46e-06 0.43

Triclosan

Q965D5_PLAFA fabI Enoyl-acyl-carrier protein reductase 8.49e-229 1.00
Q6UCJ9_TOXGO ENR Enoyl-acyl carrier reductase 1.866e-164 1.00
Q9BJJ9_PLAFA FabI Enoyl-ACP reductase 5.121e-61 1.00
M9TGV3_MYCTX inhA Enoyl-[acyl-carrier-protein] reductase [NADH] 1.336e-57 1.00
Q5NGQ3_FRATT fabI Enoyl-[acyl-carrier-protein] reductase [NADH] 8.232e-52 1.00
FABI_ECOLI fabI Enoyl-[acyl-carrier-protein] reductase [NADH] FabI 1.587e-41 1.00
Q9RMI3_STAAU fabI Enoyl-[acyl-carrier-protein] reductase [NADPH] 7.231e-41 1.00
CBR1_HUMAN CBR1 Carbonyl reductase [NADPH] 1 4.419e-25 1.00
FABI_BACSU fabI Enoyl-[acyl-carrier-protein] reductase [NADH] FabI 9.712e-23 1.00
INHA_MYCTU inhA Enoyl-[acyl-carrier-protein] reductase [NADH] 4.956e-09 1.00
FABI_STAAR fabI Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI 7.913e-09 1.00
Q8IL32_PLAF7 Heat shock protein 90, putative 0.0004052 1.00
HS90A_HUMAN HSP90AA1 Heat shock protein HSP 90-alpha 0.01912 1.00
ODPA_PEA Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial 1.609e-35 0.28
ODPB_PEA Pyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.609e-35 0.28
TTHY_HUMAN TTR Transthyretin 2.995e-28 0.72
PARG_HUMAN PARG Poly(ADP-ribose) glycohydrolase 6.654e-21 0.33
ERCC1_HUMAN ERCC1 DNA excision repair protein ERCC-1 3.809e-20 0.31
XPF_HUMAN ERCC4 DNA repair endonuclease XPF 3.809e-20 0.31
S1PR4_HUMAN S1PR4 Sphingosine 1-phosphate receptor 4 4.996e-15 0.39
PPOC_ARATH PPOX1 Protoporphyrinogen oxidase 1, chloroplastic 5.662e-15 0.45
KCMA1_HUMAN KCNMA1 Calcium-activated potassium channel subunit alpha-1 8.404e-14 0.34
SDF1_HUMAN CXCL12 Stromal cell-derived factor 1 2.33e-12 0.33
Q965D7_PLAFA fabZ Beta-hydroxyacyl-ACP dehydratase 5.256e-10 0.38
BLAB_AERHY cphA Metallo-beta-lactamase type 2 8.149e-10 0.31
SC6A2_HUMAN SLC6A2 Sodium-dependent noradrenaline transporter 8.504e-08 0.46
CYSP_PLAFA Trophozoite cysteine proteinase 1.502e-07 0.31
SC6A4_HUMAN SLC6A4 Sodium-dependent serotonin transporter 2.138e-07 0.46
Q8MTZ4_9TRYP PPase1 Vacuolar-type proton translocating pyrophosphatase 1 4.707e-07 0.30
CISY2_YEAST CIT2 Citrate synthase, peroxisomal 5.74e-07 0.28
SCNAA_RAT Scn10a Sodium channel protein type 10 subunit alpha 4.817e-06 0.34

Vemurafenib

ARAF_HUMAN ARAF Serine/threonine-protein kinase A-Raf 2.552e-200 1.00
HEMH_HUMAN FECH Ferrochelatase, mitochondrial 2.9e-124 1.00
BRAF_HUMAN BRAF Serine/threonine-protein kinase B-raf 2.785e-85 1.00
RAF1_HUMAN RAF1 RAF proto-oncogene serine/threonine-protein kinase 1.669e-55 1.00
BRAF_MOUSE Braf Serine/threonine-protein kinase B-raf 3.051e-32 1.00
M3K20_HUMAN MAP3K20 Mitogen-activated protein kinase kinase kinase 20 1.554e-15 1.00
VGFR2_HUMAN KDR Vascular endothelial growth factor receptor 2 0.9823 1.00
GPAT1_MOUSE Gpam Glycerol-3-phosphate acyltransferase 1, mitochondrial 2.718e-72 0.43
KKCC2_MOUSE Camkk2 Calcium/calmodulin-dependent protein kinase kinase 2 1.492e-51 0.34
SGK1_HUMAN SGK1 Serine/threonine-protein kinase Sgk1 2.292e-48 0.38
M3K11_MOUSE Map3k11 Mitogen-activated protein kinase kinase kinase 11 1.227e-45 0.30
PAK1_HUMAN PAK1 Serine/threonine-protein kinase PAK 1 1.036e-38 0.83
CCR9_HUMAN CCR9 C-C chemokine receptor type 9 1.693e-28 0.31
NEK11_HUMAN NEK11 Serine/threonine-protein kinase Nek11 3.323e-27 0.83
KKCC2_HUMAN CAMKK2 Calcium/calmodulin-dependent protein kinase kinase 2 2.155e-25 0.38
RIPK1_HUMAN RIPK1 Receptor-interacting serine/threonine-protein kinase 1 8.736e-25 0.83
SGK3_HUMAN SGK3 Serine/threonine-protein kinase Sgk3 1.979e-23 0.83
OXSR1_HUMAN OXSR1 Serine/threonine-protein kinase OSR1 4.987e-21 0.83
ITK_HUMAN ITK Tyrosine-protein kinase ITK/TSK 3.941e-20 0.43
AVR2B_HUMAN ACVR2B Activin receptor type-2B 1.11e-16 0.83
PB2_I34A1 PB2 Polymerase basic protein 2 4.441e-16 0.30
MYLK4_HUMAN MYLK4 Myosin light chain kinase family member 4 9.992e-16 0.83
STK16_HUMAN STK16 Serine/threonine-protein kinase 16 2.887e-15 0.83
TESK1_HUMAN TESK1 Dual specificity testis-specific protein kinase 1 3.109e-15 0.83
DYRK2_HUMAN DYRK2 Dual specificity tyrosine-phosphorylation-regulated kinase 2 4.441e-15 0.83
UFO_HUMAN AXL Tyrosine-protein kinase receptor UFO 1.255e-14 0.40
CDPK1_PLAF7 CPK1 Calcium-dependent protein kinase 1 5.884e-14 0.83
RIOK2_HUMAN RIOK2 Serine/threonine-protein kinase RIO2 1.371e-13 0.83
STK36_HUMAN STK36 Serine/threonine-protein kinase 36 1.371e-13 0.83
M3K11_HUMAN MAP3K11 Mitogen-activated protein kinase kinase kinase 11 2.932e-13 0.30
DCLK3_HUMAN DCLK3 Serine/threonine-protein kinase DCLK3 1.266e-12 0.83
PK3CA_HUMAN PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 2.091e-12 0.39
MP2K4_HUMAN MAP2K4 Dual specificity mitogen-activated protein kinase kinase 4 4.505e-12 0.83
DCLK1_HUMAN DCLK1 Serine/threonine-protein kinase DCLK1 5.986e-12 0.83
SIK1_HUMAN SIK1 Serine/threonine-protein kinase SIK1 1.399e-11 0.83
BTK_HUMAN BTK Tyrosine-protein kinase BTK 4.892e-11 0.43
HIPK3_HUMAN HIPK3 Homeodomain-interacting protein kinase 3 6.221e-11 0.83
JAK3_HUMAN JAK3 Tyrosine-protein kinase JAK3 2.851e-10 0.43
BMR1B_HUMAN BMPR1B Bone morphogenetic protein receptor type-1B 3.35e-10 0.83
HIPK1_HUMAN HIPK1 Homeodomain-interacting protein kinase 1 7.001e-10 0.83
FES_HUMAN FES Tyrosine-protein kinase Fes/Fps 1.178e-09 0.83
SRMS_HUMAN SRMS Tyrosine-protein kinase Srms 1.493e-09 0.83
EPHB6_HUMAN EPHB6 Ephrin type-B receptor 6 1.902e-09 0.83
SCNAA_MOUSE Scn10a Sodium channel protein type 10 subunit alpha 1.91e-09 0.30
SIK2_HUMAN SIK2 Serine/threonine-protein kinase SIK2 3.483e-09 0.83
DLK1_HUMAN DLK1 Protein delta homolog 1 7.778e-09 0.29
MP2K5_HUMAN MAP2K5 Dual specificity mitogen-activated protein kinase kinase 5 7.985e-09 0.83
KIT_HUMAN KIT Mast/stem cell growth factor receptor Kit 1.053e-08 0.83
E2AK4_HUMAN EIF2AK4 eIF-2-alpha kinase GCN2 1.689e-08 0.83
ABL2_HUMAN ABL2 Tyrosine-protein kinase ABL2 2.134e-08 0.83
GSK3A_HUMAN GSK3A Glycogen synthase kinase-3 alpha 2.747e-08 0.34
SGK2_HUMAN SGK2 Serine/threonine-protein kinase Sgk2 4.546e-08 0.34
DYR1B_HUMAN DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B 4.819e-08 0.34
AURKC_HUMAN AURKC Aurora kinase C 5.198e-08 0.83
PDPK1_HUMAN PDPK1 3-phosphoinositide-dependent protein kinase 1 5.461e-08 0.34
ST17A_HUMAN STK17A Serine/threonine-protein kinase 17A 6.73e-08 0.34
PKN2_HUMAN PKN2 Serine/threonine-protein kinase N2 7.841e-08 0.34
FRK_HUMAN FRK Tyrosine-protein kinase FRK 1.057e-07 0.83
ACHA7_HUMAN CHRNA7 Neuronal acetylcholine receptor subunit alpha-7 1.313e-07 0.35
STK11_HUMAN STK11 Serine/threonine-protein kinase STK11 1.859e-07 0.30
PTK6_HUMAN PTK6 Protein-tyrosine kinase 6 2.42e-07 0.83
RIPK2_HUMAN RIPK2 Receptor-interacting serine/threonine-protein kinase 2 4.754e-07 0.83
HIPK4_HUMAN HIPK4 Homeodomain-interacting protein kinase 4 5.002e-07 0.83
CLK2_HUMAN CLK2 Dual specificity protein kinase CLK2 5.528e-07 0.83
TGFR2_HUMAN TGFBR2 TGF-beta receptor type-2 6.315e-07 0.83
FGR_HUMAN FGR Tyrosine-protein kinase Fgr 7.244e-07 0.83
CSK_HUMAN CSK Tyrosine-protein kinase CSK 8.284e-07 0.83
DYR1A_HUMAN DYRK1A Dual specificity tyrosine-phosphorylation-regulated kinase 1A 8.878e-07 0.34
CDK19_HUMAN CDK19 Cyclin-dependent kinase 19 1.618e-06 0.83
KCC2B_HUMAN CAMK2B Calcium/calmodulin-dependent protein kinase type II subunit beta 1.759e-06 0.34
P85A_HUMAN PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha 2.328e-06 0.33
KCC2G_HUMAN CAMK2G Calcium/calmodulin-dependent protein kinase type II subunit gamma 2.919e-06 0.34
SLK_HUMAN SLK STE20-like serine/threonine-protein kinase 3.283e-06 0.83
PGES2_HUMAN PTGES2 Prostaglandin E synthase 2 4.207e-06 0.33
KCC1A_HUMAN CAMK1 Calcium/calmodulin-dependent protein kinase type 1 6.679e-06 0.83
LUCI_AQULA Luciferin 4-monooxygenase 7.112e-06 0.29
MINK1_HUMAN MINK1 Misshapen-like kinase 1 9.044e-06 0.83
GLR_HUMAN GCGR Glucagon receptor 9.116e-06 0.31

Pitavastatin

HMDH_HUMAN HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase 7.696e-184 1.00
HMDH_RAT Hmgcr 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1.78e-227 0.71
HMDH_MOUSE Hmgcr 3-hydroxy-3-methylglutaryl-coenzyme A reductase 4.073e-61 0.39
HMDH_PIG HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase 6.194e-23 0.37
TRPC7_HUMAN TRPC7 Short transient receptor potential channel 7 2.109e-15 0.29
TRPC6_MOUSE Trpc6 Short transient receptor potential channel 6 6.626e-11 0.29
PDE6D_HUMAN PDE6D Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta 2.446e-09 0.45
NK3R_HUMAN TACR3 Neuromedin-K receptor 3.982e-09 0.36
SO1B1_HUMAN SLCO1B1 Solute carrier organic anion transporter family member 1B1 7.567e-08 0.37
AGTRB_RAT Agtr1b Type-1B angiotensin II receptor 2.729e-07 0.37

Bedaquiline

Q5TIX5_MYCSM atpE ATP synthase subunit c 2.335e-181 1.00
ATPL_BACP3 atpE ATP synthase subunit c 2.9e-124 1.00
KCNH2_HUMAN KCNH2 Potassium voltage-gated channel subfamily H member 2 0.002542 1.00
ATP6_MYCTU atpB ATP synthase subunit a 2.089e-146 0.73
ATPA_MYCTU atpA ATP synthase subunit alpha 2.089e-146 0.73
ATPB_MYCTU atpD ATP synthase subunit beta 2.089e-146 0.73
ATPE_MYCTU atpC ATP synthase epsilon chain 2.089e-146 0.73
ATPFD_MYCTU atpFH ATP synthase subunit b-delta 2.089e-146 0.73
ATPF_MYCTU atpF ATP synthase subunit b 2.089e-146 0.73
ATPG_MYCTU atpG ATP synthase gamma chain 2.089e-146 0.73
ATPL_MYCTU atpE ATP synthase subunit c 2.089e-146 0.73

Cabozantinib

MET_HUMAN MET Hepatocyte growth factor receptor 2.165e-174 1.00
VGFR2_HUMAN KDR Vascular endothelial growth factor receptor 2 5.982e-89 1.00
EGFR_HUMAN EGFR Epidermal growth factor receptor 6.9e-38 1.00
RON_HUMAN MST1R Macrophage-stimulating protein receptor 1.547e-36 1.00
TIE2_HUMAN TEK Angiopoietin-1 receptor 4.249e-35 1.00
KIT_HUMAN KIT Mast/stem cell growth factor receptor Kit 2.442e-31 1.00
RET_HUMAN RET Proto-oncogene tyrosine-protein kinase receptor Ret 1.977e-29 1.00
FLT3_HUMAN FLT3 Receptor-type tyrosine-protein kinase FLT3 2.731e-29 1.00
VGFR1_HUMAN FLT1 Vascular endothelial growth factor receptor 1 5.555e-24 1.00
UFO_HUMAN AXL Tyrosine-protein kinase receptor UFO 8.178e-22 1.00
AURKA_HUMAN AURKA Aurora kinase A 5.346e-19 1.00
SRC_HUMAN SRC Proto-oncogene tyrosine-protein kinase Src 6.142e-09 1.00
FGFR1_HUMAN FGFR1 Fibroblast growth factor receptor 1 6.279e-08 1.00
PGFRB_HUMAN PDGFRB Platelet-derived growth factor receptor beta 1.934e-101 0.66
PGFRB_RAT Pdgfrb Platelet-derived growth factor receptor beta 1.43e-93 0.55
SCNAA_RAT Scn10a Sodium channel protein type 10 subunit alpha 8.8e-89 0.37
PGFRA_HUMAN PDGFRA Platelet-derived growth factor receptor alpha 2.223e-75 0.78
HGF_HUMAN HGF Hepatocyte growth factor 6.765e-65 0.42
S1PR2_RAT S1pr2 Sphingosine 1-phosphate receptor 2 3.528e-63 0.34
C3SLB7_ECOLX glmU Bifunctional protein GlmU 1.295e-52 0.34
FPRS1_MOUSE Fpr-s1 Formyl peptide receptor-related sequence 1 2.233e-42 0.32
CSF1R_HUMAN CSF1R Macrophage colony-stimulating factor 1 receptor 3.395e-41 0.62
VGFR2_DANRE kdr Vascular endothelial growth factor receptor 2 5.772e-41 0.29
DUS2L_HUMAN DUS2 tRNA-dihydrouridine(20) synthase [NAD(P)+]-like 5.748e-39 0.31
NTR2_RAT Ntsr2 Neurotensin receptor type 2 3.107e-38 0.36
S1PR2_HUMAN S1PR2 Sphingosine 1-phosphate receptor 2 4.083e-37 0.35
GLUT4_RAT Slc2a4 Solute carrier family 2, facilitated glucose transporter member 4 2.333e-36 0.29
GTR8_HUMAN SLC2A8 Solute carrier family 2, facilitated glucose transporter member 8 2.333e-36 0.29
BRAF_HUMAN BRAF Serine/threonine-protein kinase B-raf 7.984e-34 0.62
PDE3B_HUMAN PDE3B cGMP-inhibited 3',5'-cyclic phosphodiesterase B 3.424e-31 0.31
VGFR3_HUMAN FLT4 Vascular endothelial growth factor receptor 3 7.437e-30 0.62
CDKL3_HUMAN CDKL3 Cyclin-dependent kinase-like 3 1.275e-29 0.62
TF7L2_HUMAN TCF7L2 Transcription factor 7-like 2 3.178e-28 0.33
CTNB1_HUMAN CTNNB1 Catenin beta-1 4.973e-26 0.33
ERBB4_HUMAN ERBB4 Receptor tyrosine-protein kinase erbB-4 6.195e-26 0.62
EPHB2_HUMAN EPHB2 Ephrin type-B receptor 2 1.791e-23 0.62
CDK9_HUMAN CDK9 Cyclin-dependent kinase 9 2.313e-23 0.62
G3V783_RAT Ripk2 Receptor-interacting serine/threonine-protein kinase 2 5.518e-23 0.28
PDE3A_HUMAN PDE3A cGMP-inhibited 3',5'-cyclic phosphodiesterase A 8.292e-23 0.31
LCK_HUMAN LCK Tyrosine-protein kinase Lck 1.297e-22 0.62
CDPK1_PLAF7 CPK1 Calcium-dependent protein kinase 1 2.957e-22 0.62
MYO3B_HUMAN MYO3B Myosin-IIIb 9.496e-22 0.62
PYGL_MOUSE Pygl Glycogen phosphorylase, liver form 1.822e-21 0.30
GYRB_MYCS2 gyrB DNA gyrase subunit B 2.685e-21 0.36
ERBB3_HUMAN ERBB3 Receptor tyrosine-protein kinase erbB-3 3.107e-21 0.62
NLK_HUMAN NLK Serine/threonine-protein kinase NLK 4.886e-21 0.62
IRAK3_HUMAN IRAK3 Interleukin-1 receptor-associated kinase 3 1.357e-20 0.62
E2AK3_HUMAN EIF2AK3 Eukaryotic translation initiation factor 2-alpha kinase 3 1.674e-20 0.43
CDKL2_HUMAN CDKL2 Cyclin-dependent kinase-like 2 2.397e-20 0.62
F16P1_PIG FBP1 Fructose-1,6-bisphosphatase 1 6.088e-20 0.33
PYGL_RAT Pygl Glycogen phosphorylase, liver form 9.903e-20 0.30
AUKBA_XENLA aurkb-a Aurora kinase B-A 2.621e-19 0.31
TESK1_HUMAN TESK1 Dual specificity testis-specific protein kinase 1 2.933e-19 0.62
ABL1_MOUSE Abl1 Tyrosine-protein kinase ABL1 3.548e-19 0.30
CDK15_HUMAN CDK15 Cyclin-dependent kinase 15 4.543e-19 0.62
O68720_YERPE yopH Targeted effector protein 5.245e-19 0.33
MAK_HUMAN MAK Serine/threonine-protein kinase MAK 6.204e-19 0.62
RIPK2_HUMAN RIPK2 Receptor-interacting serine/threonine-protein kinase 2 1.276e-18 0.62
EPHA8_HUMAN EPHA8 Ephrin type-A receptor 8 2.08e-18 0.62
EPHB6_HUMAN EPHB6 Ephrin type-B receptor 6 2.116e-18 0.62
MECP2_HUMAN MECP2 Methyl-CpG-binding protein 2 2.749e-18 0.29
FGFR2_HUMAN FGFR2 Fibroblast growth factor receptor 2 2.77e-18 0.62
RAF1_HUMAN RAF1 RAF proto-oncogene serine/threonine-protein kinase 2.985e-18 0.62
GLUT4_HUMAN SLC2A4 Solute carrier family 2, facilitated glucose transporter member 4 3.809e-18 0.29
AURKB_HUMAN AURKB Aurora kinase B 9.351e-18 0.62
LPAR5_HUMAN LPAR5 Lysophosphatidic acid receptor 5 2.214e-17 0.36
MP2K5_HUMAN MAP2K5 Dual specificity mitogen-activated protein kinase kinase 5 3.714e-17 0.62
MYLK3_HUMAN MYLK3 Myosin light chain kinase 3 4.155e-17 0.62
LYOX_HUMAN LOX Protein-lysine 6-oxidase 4.742e-17 0.32
CDK14_HUMAN CDK14 Cyclin-dependent kinase 14 1.11e-16 0.62
EPHA1_HUMAN EPHA1 Ephrin type-A receptor 1 1.11e-16 0.62
FGR_HUMAN FGR Tyrosine-protein kinase Fgr 1.11e-16 0.62
NEK9_HUMAN NEK9 Serine/threonine-protein kinase Nek9 1.11e-16 0.62
STK10_HUMAN STK10 Serine/threonine-protein kinase 10 1.11e-16 0.62
CDK17_HUMAN CDK17 Cyclin-dependent kinase 17 4.441e-16 0.62
CDKL5_HUMAN CDKL5 Cyclin-dependent kinase-like 5 8.882e-16 0.62
FAK2_MOUSE Ptk2b Protein-tyrosine kinase 2-beta 8.882e-16 0.41
MYO3A_HUMAN MYO3A Myosin-IIIa 8.882e-16 0.62
NU1M_BOVIN MT-ND1 NADH-ubiquinone oxidoreductase chain 1 1.332e-15 0.32
STK4_HUMAN STK4 Serine/threonine-protein kinase 4 1.443e-15 0.62
M3K19_HUMAN MAP3K19 Mitogen-activated protein kinase kinase kinase 19 3.22e-15 0.62
EAA4_RAT Slc1a6 Excitatory amino acid transporter 4 3.553e-15 0.29
MUSK_HUMAN MUSK Muscle, skeletal receptor tyrosine-protein kinase 3.664e-15 0.62
STA5A_HUMAN STAT5A Signal transducer and activator of transcription 5A 3.997e-15 0.34
CD11A_HUMAN CDK11A Cyclin-dependent kinase 11A 4.996e-15 0.62
CDK13_HUMAN CDK13 Cyclin-dependent kinase 13 4.996e-15 0.62
MRCKB_HUMAN CDC42BPB Serine/threonine-protein kinase MRCK beta 4.996e-15 0.62
MRCKG_HUMAN CDC42BPG Serine/threonine-protein kinase MRCK gamma 4.996e-15 0.62
NEK11_HUMAN NEK11 Serine/threonine-protein kinase Nek11 6.328e-15 0.45
MET_MOUSE Met Hepatocyte growth factor receptor 7.327e-15 0.33
STK36_HUMAN STK36 Serine/threonine-protein kinase 36 9.104e-15 0.62
ABCG2_HUMAN ABCG2 Broad substrate specificity ATP-binding cassette transporter ABCG2 1.088e-14 0.33
EPHA2_HUMAN EPHA2 Ephrin type-A receptor 2 1.221e-14 0.62
FAK2_HUMAN PTK2B Protein-tyrosine kinase 2-beta 1.255e-14 0.62
KC1D_RAT Csnk1d Casein kinase I isoform delta 2.676e-14 0.33
MYLK2_HUMAN MYLK2 Myosin light chain kinase 2, skeletal/cardiac muscle 4.818e-14 0.62
ERBB2_HUMAN ERBB2 Receptor tyrosine-protein kinase erbB-2 9.093e-14 0.62
HUNK_HUMAN HUNK Hormonally up-regulated neu tumor-associated kinase 9.57e-14 0.62
CCR4_MOUSE Ccr4 C-C chemokine receptor type 4 1.011e-13 0.33
MK15_HUMAN MAPK15 Mitogen-activated protein kinase 15 1.027e-13 0.62
SRMS_HUMAN SRMS Tyrosine-protein kinase Srms 1.658e-13 0.62
5HT1D_RAT Htr1d 5-hydroxytryptamine receptor 1D 2.034e-13 0.29
EPHA7_HUMAN EPHA7 Ephrin type-A receptor 7 2.094e-13 0.62
TNK1_HUMAN TNK1 Non-receptor tyrosine-protein kinase TNK1 2.094e-13 0.62
ABL2_HUMAN ABL2 Tyrosine-protein kinase ABL2 2.884e-13 0.62
CD11B_HUMAN CDK11B Cyclin-dependent kinase 11B 3.334e-13 0.62
ALBU_BOVIN ALB Serum albumin 3.508e-13 0.31
CSK_HUMAN CSK Tyrosine-protein kinase CSK 3.828e-13 0.62
EPHA5_HUMAN EPHA5 Ephrin type-A receptor 5 4.098e-13 0.62
CDK18_HUMAN CDK18 Cyclin-dependent kinase 18 1.028e-12 0.62
TAOK2_HUMAN TAOK2 Serine/threonine-protein kinase TAO2 1.41e-12 0.62
IGF1R_HUMAN IGF1R Insulin-like growth factor 1 receptor 1.443e-12 0.62
EPHB4_HUMAN EPHB4 Ephrin type-B receptor 4 2.02e-12 0.62
TSPO_HUMAN TSPO Translocator protein 2.496e-12 0.31
RIPK4_HUMAN RIPK4 Receptor-interacting serine/threonine-protein kinase 4 2.857e-12 0.62
EPHA4_HUMAN EPHA4 Ephrin type-A receptor 4 4.283e-12 0.62
ANDR_MOUSE Ar Androgen receptor 6.049e-12 0.30
HDAC1_MOUSE Hdac1 Histone deacetylase 1 6.928e-12 0.31
CTRO_HUMAN CIT Citron Rho-interacting kinase 7.17e-12 0.62
HIPK3_HUMAN HIPK3 Homeodomain-interacting protein kinase 3 7.17e-12 0.62
CDK16_HUMAN CDK16 Cyclin-dependent kinase 16 7.254e-12 0.62
INSRR_HUMAN INSRR Insulin receptor-related protein 7.262e-12 0.62
M3K4_HUMAN MAP3K4 Mitogen-activated protein kinase kinase kinase 4 7.262e-12 0.62
NTR1_RAT Ntsr1 Neurotensin receptor type 1 1.1e-11 0.35
AURKC_HUMAN AURKC Aurora kinase C 1.131e-11 0.62
M4K1_HUMAN MAP4K1 Mitogen-activated protein kinase kinase kinase kinase 1 1.171e-11 0.62
DUSTY_HUMAN DSTYK Dual serine/threonine and tyrosine protein kinase 1.709e-11 0.62
EPHB1_HUMAN EPHB1 Ephrin type-B receptor 1 1.871e-11 0.62
HIPK4_HUMAN HIPK4 Homeodomain-interacting protein kinase 4 2.421e-11 0.62
EPHA6_HUMAN EPHA6 Ephrin type-A receptor 6 2.928e-11 0.62
M3K13_HUMAN MAP3K13 Mitogen-activated protein kinase kinase kinase 13 3.758e-11 0.62
Q25615_ONCVO Chitinase 6.527e-11 0.32
ANKK1_HUMAN ANKK1 Ankyrin repeat and protein kinase domain-containing protein 1 7.788e-11 0.62
STK35_HUMAN STK35 Serine/threonine-protein kinase 35 7.788e-11 0.62
HIPK1_HUMAN HIPK1 Homeodomain-interacting protein kinase 1 1.003e-10 0.62
TIE1_HUMAN TIE1 Tyrosine-protein kinase receptor Tie-1 1.003e-10 0.62
DDR2_HUMAN DDR2 Discoidin domain-containing receptor 2 1.251e-10 0.62
STK25_HUMAN STK25 Serine/threonine-protein kinase 25 1.532e-10 0.62
ENPP1_HUMAN ENPP1 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 2.072e-10 0.29
BRAF_MOUSE Braf Serine/threonine-protein kinase B-raf 2.207e-10 0.29
KKCC1_HUMAN CAMKK1 Calcium/calmodulin-dependent protein kinase kinase 1 2.876e-10 0.62
ULK3_HUMAN ULK3 Serine/threonine-protein kinase ULK3 2.876e-10 0.62
STA5B_HUMAN STAT5B Signal transducer and activator of transcription 5B 2.985e-10 0.34
THB_RAT Thrb Thyroid hormone receptor beta 3.95e-10 0.31
PYGM_HUMAN PYGM Glycogen phosphorylase, muscle form 5.303e-10 0.32
LPAR1_HUMAN LPAR1 Lysophosphatidic acid receptor 1 6.301e-10 0.36
ADA17_PIG ADAM17 Disintegrin and metalloproteinase domain-containing protein 17 6.631e-10 0.30
MP2K1_HUMAN MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 1.722e-09 0.62
PTK6_HUMAN PTK6 Protein-tyrosine kinase 6 1.801e-09 0.62
LYN_HUMAN LYN Tyrosine-protein kinase Lyn 2.047e-09 0.62
EPHA3_HUMAN EPHA3 Ephrin type-A receptor 3 3.219e-09 0.62
TNIK_HUMAN TNIK TRAF2 and NCK-interacting protein kinase 3.272e-09 0.62
M4K5_HUMAN MAP4K5 Mitogen-activated protein kinase kinase kinase kinase 5 3.312e-09 0.62
LOXL2_HUMAN LOXL2 Lysyl oxidase homolog 2 3.45e-09 0.32
M3K20_HUMAN MAP3K20 Mitogen-activated protein kinase kinase kinase 20 3.744e-09 0.62
M3K3_HUMAN MAP3K3 Mitogen-activated protein kinase kinase kinase 3 3.882e-09 0.62
PAK3_HUMAN PAK3 Serine/threonine-protein kinase PAK 3 3.882e-09 0.62
PRKDC_HUMAN PRKDC DNA-dependent protein kinase catalytic subunit 4.521e-09 0.33
DDR1_HUMAN DDR1 Epithelial discoidin domain-containing receptor 1 5.601e-09 0.62
S22AC_HUMAN SLC22A12 Solute carrier family 22 member 12 6.107e-09 0.32
BLK_HUMAN BLK Tyrosine-protein kinase Blk 6.195e-09 0.62
GRM4_RAT Grm4 Metabotropic glutamate receptor 4 6.244e-09 0.33
MDR1_HUMAN ABCB1 ATP-dependent translocase ABCB1 6.296e-09 0.34
EPHB3_HUMAN EPHB3 Ephrin type-B receptor 3 9.038e-09 0.62
SIK1_HUMAN SIK1 Serine/threonine-protein kinase SIK1 9.038e-09 0.62
SLK_HUMAN SLK STE20-like serine/threonine-protein kinase 1.286e-08 0.62
STK33_HUMAN STK33 Serine/threonine-protein kinase 33 1.33e-08 0.62
GYRB_MYCSM gyrB DNA gyrase subunit B 1.359e-08 0.34
SRPK1_HUMAN SRPK1 SRSF protein kinase 1 1.379e-08 0.34
MP2K2_HUMAN MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 1.427e-08 0.62
SHH_MOUSE Shh Sonic hedgehog protein 1.507e-08 0.30
M4K3_HUMAN MAP4K3 Mitogen-activated protein kinase kinase kinase kinase 3 1.933e-08 0.62
FES_HUMAN FES Tyrosine-protein kinase Fes/Fps 2.328e-08 0.62
M3K2_HUMAN MAP3K2 Mitogen-activated protein kinase kinase kinase 2 2.75e-08 0.62
TEC_HUMAN TEC Tyrosine-protein kinase Tec 5.304e-08 0.62
ABL1_HUMAN ABL1 Tyrosine-protein kinase ABL1 5.332e-08 0.62
E2AK1_HUMAN EIF2AK1 Eukaryotic translation initiation factor 2-alpha kinase 1 9.662e-08 0.62
CDK3_HUMAN CDK3 Cyclin-dependent kinase 3 1.037e-07 0.30
LIMK2_HUMAN LIMK2 LIM domain kinase 2 1.135e-07 0.62
NTRK3_HUMAN NTRK3 NT-3 growth factor receptor 1.193e-07 0.62
FRK_HUMAN FRK Tyrosine-protein kinase FRK 2.494e-07 0.62
MK01_HUMAN MAPK1 Mitogen-activated protein kinase 1 3.109e-07 0.34
MINK1_HUMAN MINK1 Misshapen-like kinase 1 3.6e-07 0.62
NTRK2_HUMAN NTRK2 BDNF/NT-3 growth factors receptor 4.527e-07 0.62
CYSP_PLAFA Trophozoite cysteine proteinase 4.8e-07 0.29
SIK2_HUMAN SIK2 Serine/threonine-protein kinase SIK2 5.554e-07 0.62
MK13_HUMAN MAPK13 Mitogen-activated protein kinase 13 6.481e-07 0.62
PSBA_SPIOL psbA Photosystem II protein D1 6.498e-07 0.32
M3K10_HUMAN MAP3K10 Mitogen-activated protein kinase kinase kinase 10 6.88e-07 0.62
ROS1_HUMAN ROS1 Proto-oncogene tyrosine-protein kinase ROS 7.094e-07 0.62
HIPK2_HUMAN HIPK2 Homeodomain-interacting protein kinase 2 8.367e-07 0.62
5HT1D_CAVPO HTR1D 5-hydroxytryptamine receptor 1D 9.396e-07 0.29
PRIO_SHEEP PRNP Major prion protein 1.241e-06 0.30
FPR2_HUMAN FPR2 N-formyl peptide receptor 2 1.441e-06 0.35
SENP7_HUMAN SENP7 Sentrin-specific protease 7 1.576e-06 0.33
KCC1A_HUMAN CAMK1 Calcium/calmodulin-dependent protein kinase type 1 1.935e-06 0.62
FYN_HUMAN FYN Tyrosine-protein kinase Fyn 2.027e-06 0.62
MK14_MOUSE Mapk14 Mitogen-activated protein kinase 14 2.028e-06 0.31
MK14_HUMAN MAPK14 Mitogen-activated protein kinase 14 2.192e-06 0.62
FER_HUMAN FER Tyrosine-protein kinase Fer 2.295e-06 0.62
INSR_HUMAN INSR Insulin receptor 2.316e-06 0.62
KKCC2_HUMAN CAMKK2 Calcium/calmodulin-dependent protein kinase kinase 2 3.009e-06 0.62
TGFR2_HUMAN TGFBR2 TGF-beta receptor type-2 3.409e-06 0.45
MERTK_HUMAN MERTK Tyrosine-protein kinase Mer 4.055e-06 0.62
ARAF_HUMAN ARAF Serine/threonine-protein kinase A-Raf 4.465e-06 0.29
CHK2_HUMAN CHEK2 Serine/threonine-protein kinase Chk2 4.531e-06 0.62
LUCI_AQULA Luciferin 4-monooxygenase 5.99e-06 0.29
PLK4_HUMAN PLK4 Serine/threonine-protein kinase PLK4 6.382e-06 0.62
M3K11_HUMAN MAP3K11 Mitogen-activated protein kinase kinase kinase 11 6.396e-06 0.62
TXK_HUMAN TXK Tyrosine-protein kinase TXK 6.396e-06 0.62
AGP1_YEAST AGP1 General amino acid permease AGP1 7.112e-06 0.29
ACVR1_HUMAN ACVR1 Activin receptor type-1 8.384e-06 0.33
BMR1B_HUMAN BMPR1B Bone morphogenetic protein receptor type-1B 9.106e-06 0.45
O77823_PIG PDE4A Cyclic AMP-specific phosphodiesterase SSPDE4A1A 9.291e-06 0.31
MP2K6_HUMAN MAP2K6 Dual specificity mitogen-activated protein kinase kinase 6 9.349e-06 0.29
YES_HUMAN YES1 Tyrosine-protein kinase Yes 9.926e-06 0.62

Lomitapide

MTP_HUMAN MTTP Microsomal triglyceride transfer protein large subunit 2.294e-170 1.00
MTP_BOVIN MTTP Microsomal triglyceride transfer protein large subunit 8.672e-85 0.46
APOB_HUMAN APOB Apolipoprotein B-100 2.788e-69 0.42
E2AK3_RAT Eif2ak3 Eukaryotic translation initiation factor 2-alpha kinase 3 4.754e-38 0.30
CCR2_HUMAN CCR2 C-C chemokine receptor type 2 2.89e-37 0.35
CASR_MOUSE Casr Extracellular calcium-sensing receptor 7.142e-37 0.29
CRFR2_HUMAN CRHR2 Corticotropin-releasing factor receptor 2 1.827e-32 0.32
DCNL1_HUMAN DCUN1D1 DCN1-like protein 1 3.349e-32 0.33
SC6A5_HUMAN SLC6A5 Sodium- and chloride-dependent glycine transporter 2 7.241e-29 0.44
TRPV4_HUMAN TRPV4 Transient receptor potential cation channel subfamily V member 4 7.049e-24 0.35
Q6A2E2_AEDAE ace-1 Acetylcholinesterase 7.318e-23 0.28
MCHR1_HUMAN MCHR1 Melanin-concentrating hormone receptor 1 9.668e-23 0.36
HYES_MOUSE Ephx2 Bifunctional epoxide hydrolase 2 3.51e-21 0.36
CRFR1_HUMAN CRHR1 Corticotropin-releasing factor receptor 1 2.448e-20 0.35
HPGDS_HUMAN HPGDS Hematopoietic prostaglandin D synthase 4.125e-17 0.36
DRD4_HUMAN DRD4 D(4) dopamine receptor 1.11e-16 0.47
CCR3_HUMAN CCR3 C-C chemokine receptor type 3 2.22e-16 0.43
SCN1A_HUMAN SCN1A Sodium channel protein type 1 subunit alpha 5.551e-16 0.38
SCN9A_MOUSE Scn9a Sodium channel protein type 9 subunit alpha 8.804e-14 0.38
S6A12_HUMAN SLC6A12 Sodium- and chloride-dependent betaine transporter 9.167e-13 0.31
5HT4R_HUMAN HTR4 5-hydroxytryptamine receptor 4 1.709e-12 0.36
CCR2_MOUSE Ccr2 C-C chemokine receptor type 2 1.984e-12 0.31
DRD2_HUMAN DRD2 D(2) dopamine receptor 2.189e-12 0.42
SMO_MOUSE Smo Smoothened homolog 4.168e-12 0.37
CCR2_RAT Ccr2 C-C chemokine receptor type 2 4.628e-12 0.29
DRD3_HUMAN DRD3 D(3) dopamine receptor 4.527e-11 0.36
TRPV4_MOUSE Trpv4 Transient receptor potential cation channel subfamily V member 4 8.758e-11 0.32
HYES_HUMAN EPHX2 Bifunctional epoxide hydrolase 2 3.428e-10 0.36
5HT7R_HUMAN HTR7 5-hydroxytryptamine receptor 7 5.91e-10 0.38
SFRP1_HUMAN SFRP1 Secreted frizzled-related protein 1 1.316e-09 0.33
PDK2_HUMAN PDK2 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 4.331e-09 0.33
ACM1_HUMAN CHRM1 Muscarinic acetylcholine receptor M1 8.22e-09 0.31
ACM3_HUMAN CHRM3 Muscarinic acetylcholine receptor M3 1.378e-08 0.31
5HT4R_RAT Htr4 5-hydroxytryptamine receptor 4 1.408e-08 0.35
ANM6_HUMAN PRMT6 Protein arginine N-methyltransferase 6 1.894e-07 0.36
P3C2A_HUMAN PIK3C2A Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha 2.532e-07 0.28
DRD1_BOVIN DRD1 D(1A) dopamine receptor 3.283e-07 0.30
DRD3_RAT Drd3 D(3) dopamine receptor 5.291e-07 0.32
KSYK_HUMAN SYK Tyrosine-protein kinase SYK 7.202e-07 0.33
CDKA1_HUMAN CDK2AP1 Cyclin-dependent kinase 2-associated protein 1 1.297e-06 0.30
CAC1G_HUMAN CACNA1G Voltage-dependent T-type calcium channel subunit alpha-1G 2.02e-06 0.32
5HT2A_HUMAN HTR2A 5-hydroxytryptamine receptor 2A 2.062e-06 0.39
MTLR_HUMAN MLNR Motilin receptor 2.098e-06 0.32
ADA1A_RABIT ADRA1A Alpha-1A adrenergic receptor 2.713e-06 0.29
CARM1_HUMAN CARM1 Histone-arginine methyltransferase CARM1 3.065e-06 0.36
5HT2A_RAT Htr2a 5-hydroxytryptamine receptor 2A 4.139e-06 0.39
SGMR1_MOUSE Sigmar1 Sigma non-opioid intracellular receptor 1 6.074e-06 0.30
CP2J2_HUMAN CYP2J2 Cytochrome P450 2J2 6.644e-06 0.29
TRPV1_HUMAN TRPV1 Transient receptor potential cation channel subfamily V member 1 7.095e-06 0.35
SMYD3_HUMAN SMYD3 Histone-lysine N-methyltransferase SMYD3 7.537e-06 0.28
SGMR1_HUMAN SIGMAR1 Sigma non-opioid intracellular receptor 1 7.763e-06 0.41
KCNH2_HUMAN KCNH2 Potassium voltage-gated channel subfamily H member 2 9.387e-06 0.33

Mirdametinib

MP2K1_HUMAN MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 1.184e-154 1.00
MP2K1_MOUSE Map2k1 Dual specificity mitogen-activated protein kinase kinase 1 1.778e-101 1.00
MK01_HUMAN MAPK1 Mitogen-activated protein kinase 1 0.9551 1.00
BRAF_HUMAN BRAF Serine/threonine-protein kinase B-raf 0.9676 1.00
NPT2C_HUMAN SLC34A3 Sodium-dependent phosphate transport protein 2C 6.145e-36 0.28
S20A1_HUMAN SLC20A1 Sodium-dependent phosphate transporter 1 3.817e-23 0.28
NPT2A_HUMAN SLC34A1 Sodium-dependent phosphate transport protein 2A 6.109e-18 0.28
M3K9_HUMAN MAP3K9 Mitogen-activated protein kinase kinase kinase 9 3.426e-09 0.38
MP2K2_HUMAN MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 4.702e-06 0.57

Carfilzomib

PSB8_HUMAN PSMB8 Proteasome subunit beta type-8 1.443e-147 1.00
ADRM1_HUMAN ADRM1 Proteasomal ubiquitin receptor ADRM1 4.347e-144 1.00
PRS10_HUMAN PSMC6 26S proteasome regulatory subunit 10B 4.347e-144 1.00
PRS4_HUMAN PSMC1 26S proteasome regulatory subunit 4 4.347e-144 1.00
PRS6A_HUMAN PSMC3 26S proteasome regulatory subunit 6A 4.347e-144 1.00
PRS6B_HUMAN PSMC4 26S proteasome regulatory subunit 6B 4.347e-144 1.00
PRS7_HUMAN PSMC2 26S proteasome regulatory subunit 7 4.347e-144 1.00
PRS8_HUMAN PSMC5 26S proteasome regulatory subunit 8 4.347e-144 1.00
PSD11_HUMAN PSMD11 26S proteasome non-ATPase regulatory subunit 11 4.347e-144 1.00
PSD12_HUMAN PSMD12 26S proteasome non-ATPase regulatory subunit 12 4.347e-144 1.00
PSD13_HUMAN PSMD13 26S proteasome non-ATPase regulatory subunit 13 4.347e-144 1.00
PSMD1_HUMAN PSMD1 26S proteasome non-ATPase regulatory subunit 1 4.347e-144 1.00
PSMD2_HUMAN PSMD2 26S proteasome non-ATPase regulatory subunit 2 4.347e-144 1.00
PSMD3_HUMAN PSMD3 26S proteasome non-ATPase regulatory subunit 3 4.347e-144 1.00
PSMD4_HUMAN PSMD4 26S proteasome non-ATPase regulatory subunit 4 4.347e-144 1.00
PSMD6_HUMAN PSMD6 26S proteasome non-ATPase regulatory subunit 6 4.347e-144 1.00
PSMD7_HUMAN PSMD7 26S proteasome non-ATPase regulatory subunit 7 4.347e-144 1.00
PSMD8_HUMAN PSMD8 26S proteasome non-ATPase regulatory subunit 8 4.347e-144 1.00
SEM1_HUMAN SEM1 26S proteasome complex subunit SEM1 4.347e-144 1.00
PSB9_HUMAN PSMB9 Proteasome subunit beta type-9 9.351e-121 1.00
PSB5_HUMAN PSMB5 Proteasome subunit beta type-5 8.121e-117 1.00
PSB2_HUMAN PSMB2 Proteasome subunit beta type-2 1.433e-95 1.00
PSB10_HUMAN PSMB10 Proteasome subunit beta type-10 3.083e-86 1.00
PSA1_HUMAN PSMA1 Proteasome subunit alpha type-1 7.587e-76 1.00
PSA2_HUMAN PSMA2 Proteasome subunit alpha type-2 7.587e-76 1.00
PSA3_HUMAN PSMA3 Proteasome subunit alpha type-3 7.587e-76 1.00
PSA4_HUMAN PSMA4 Proteasome subunit alpha type-4 7.587e-76 1.00
PSA5_HUMAN PSMA5 Proteasome subunit alpha type-5 7.587e-76 1.00
PSA6_HUMAN PSMA6 Proteasome subunit alpha type-6 7.587e-76 1.00
PSA7_HUMAN PSMA7 Proteasome subunit alpha type-7 7.587e-76 1.00
PSB11_HUMAN PSMB11 Proteasome subunit beta type-11 7.587e-76 1.00
PSB3_HUMAN PSMB3 Proteasome subunit beta type-3 7.587e-76 1.00
PSB4_HUMAN PSMB4 Proteasome subunit beta type-4 7.587e-76 1.00
PSB6_HUMAN PSMB6 Proteasome subunit beta type-6 7.587e-76 1.00
PSB7_HUMAN PSMB7 Proteasome subunit beta type-7 7.587e-76 1.00
PSMA8_HUMAN PSMA8 Proteasome subunit alpha-type 8 7.587e-76 1.00
PSB1_HUMAN PSMB1 Proteasome subunit beta type-1 3.191e-58 1.00
PSDE_HUMAN PSMD14 26S proteasome non-ATPase regulatory subunit 14 2.112e-42 1.00
GSTO1_HUMAN GSTO1 Glutathione S-transferase omega-1 9.712e-23 1.00
CAN2_HUMAN CAPN2 Calpain-2 catalytic subunit 2.641e-170 0.48
CDYL2_HUMAN CDYL2 Chromodomain Y-like protein 2 3.105e-149 0.41
CBX7_HUMAN CBX7 Chromobox protein homolog 7 3.041e-140 0.39
CATB_BOVIN CTSB Cathepsin B 4.029e-128 0.40
CBX4_HUMAN CBX4 E3 SUMO-protein ligase CBX4 3.604e-124 0.39
CAN1_HUMAN CAPN1 Calpain-1 catalytic subunit 6.1e-123 0.48
OPRM_RAT Oprm1 Mu-type opioid receptor 3.033e-122 0.47
AMD_RAT Pam Peptidylglycine alpha-amidating monooxygenase 2.68e-119 0.42
RENI_HUMAN REN Renin 1.792e-116 0.43
CBX8_HUMAN CBX8 Chromobox protein homolog 8 4.344e-112 0.36
NK2R_HUMAN TACR2 Substance-K receptor 1.082e-106 0.46
MMP9_RAT Mmp9 Matrix metalloproteinase-9 4.993e-102 0.46
THER_BACTH npr Thermolysin 1.56e-99 0.39
KLK3_HUMAN KLK3 Prostate-specific antigen 9.283e-97 0.36
FCER2_HUMAN FCER2 Low affinity immunoglobulin epsilon Fc receptor 1.158e-95 0.37
FPR1_HUMAN FPR1 fMet-Leu-Phe receptor 1.151e-92 0.43
TIMP3_RAT Timp3 Metalloproteinase inhibitor 3 3.226e-92 0.45
OPRD_MOUSE Oprd1 Delta-type opioid receptor 7.848e-92 0.47
CPNS1_PIG CAPNS1 Calpain small subunit 1 8.324e-92 0.39
OPRD_RAT Oprd1 Delta-type opioid receptor 1.986e-91 0.43
Q8CGM4_CAVPO OPRM1 Mu-opioid receptor 1.591e-89 0.39
QRFPR_HUMAN QRFPR Pyroglutamylated RF-amide peptide receptor 3.333e-89 0.41
MMP8_RAT Mmp8 Neutrophil collagenase 5.892e-88 0.46
MMP3_HUMAN MMP3 Stromelysin-1 2.257e-87 0.46
OPRM_CAVPO OPRM1 Mu-type opioid receptor 2.627e-87 0.47
NEP_MOUSE Mme Neprilysin 5.793e-80 0.42
CATD_BOVIN CTSD Cathepsin D 9.043e-79 0.40
NK1R_CAVPO TACR1 Substance-P receptor 8.952e-78 0.42
BLA1_STEMA Metallo-beta-lactamase L1 type 3 1.227e-73 0.35
CATB_HUMAN CTSB Cathepsin B 2.291e-73 0.48
RENI_RAT Ren1 Renin 1.921e-72 0.39
CYSP_TRYCR Cruzipain 5.084e-72 0.49
MMP1_HUMAN MMP1 Interstitial collagenase 6.996e-72 0.44
VM1B1_BOTAS Snake venom metalloproteinase BaP1 1.718e-71 0.46
MBOA4_HUMAN MBOAT4 Ghrelin O-acyltransferase 3.133e-71 0.40
NEP_RABIT MME Neprilysin 8.698e-71 0.39
CAC1B_HUMAN CACNA1B Voltage-dependent N-type calcium channel subunit alpha-1B 1.958e-70 0.40
NK2R_MESAU TACR2 Substance-K receptor 4.209e-69 0.42
CATE_HUMAN CTSE Cathepsin E 4.289e-69 0.36
CATL1_HUMAN CTSL Cathepsin L1 5.938e-69 0.44
CPNS1_HUMAN CAPNS1 Calpain small subunit 1 3.229e-67 0.35
ACE2_HUMAN ACE2 Angiotensin-converting enzyme 2 2.485e-66 0.36
NK2R_RAT Tacr2 Substance-K receptor 5.416e-65 0.38
MC5R_MOUSE Mc5r Melanocortin receptor 5 8.857e-65 0.32
MMP12_HUMAN MMP12 Macrophage metalloelastase 2.424e-64 0.43
SHC1_HUMAN SHC1 SHC-transforming protein 1 3.114e-64 0.33
CAN2_BOVIN CAPN2 Calpain-2 catalytic subunit 1.496e-62 0.39
MMP8_HUMAN MMP8 Neutrophil collagenase 3.06e-61 0.48
LSHR_RAT Lhcgr Lutropin-choriogonadotropic hormone receptor 4.516e-61 0.33
MMP10_HUMAN MMP10 Stromelysin-2 5.804e-61 0.43
NK1R_RAT Tacr1 Substance-P receptor 8.606e-61 0.41
ACE_HUMAN ACE Angiotensin-converting enzyme 1.01e-60 0.39
NPFF2_RAT Npffr2 Neuropeptide FF receptor 2 1.273e-60 0.36
NPFF1_HUMAN NPFFR1 Neuropeptide FF receptor 1 3.031e-60 0.33
PAR2_HUMAN F2RL1 Proteinase-activated receptor 2 3.774e-60 0.37
GSP_CRIFA GSP Glutathionylspermidine synthase 1.343e-59 0.33
ERAP2_HUMAN ERAP2 Endoplasmic reticulum aminopeptidase 2 1.476e-58 0.36
ACE_MOUSE Ace Angiotensin-converting enzyme 4.278e-58 0.42
ACE2_RAT Ace2 Angiotensin-converting enzyme 2 4.363e-58 0.35
RIR1_MOUSE Rrm1 Ribonucleoside-diphosphate reductase large subunit 1.362e-57 0.37
Q95PM0_TRYBR rhodesain Cysteine protease 3.383e-57 0.36
NPFF2_HUMAN NPFFR2 Neuropeptide FF receptor 2 4.324e-57 0.33
NEP_HUMAN MME Neprilysin 2.415e-56 0.41
AMPN_PIG ANPEP Aminopeptidase N 2.869e-56 0.40
PEPC_HUMAN PGC Gastricsin 5.3e-56 0.36
MC4R_MOUSE Mc4r Melanocortin receptor 4 2.425e-55 0.33
NK3R_RAT Tacr3 Neuromedin-K receptor 5.065e-54 0.36
PLMN_BOVIN PLG Plasminogen 1.578e-53 0.38
KISSR_HUMAN KISS1R KiSS-1 receptor 8.1e-53 0.34
NTR1_HUMAN NTSR1 Neurotensin receptor type 1 8.683e-53 0.34
CAN1_PIG CAPN1 Calpain-1 catalytic subunit 5.035e-52 0.42
PEPA5_HUMAN PGA5 Pepsin A-5 6.258e-51 0.36
LCAP_HUMAN LNPEP Leucyl-cystinyl aminopeptidase 4.143e-50 0.36
OPRK_MOUSE Oprk1 Kappa-type opioid receptor 5.252e-50 0.47
Q6MGC4_RAT Pfdn6 H2-K region expressed gene 2, rat orthologue 6.91e-50 0.40
MSHR_MOUSE Mc1r Melanocyte-stimulating hormone receptor 9.41e-50 0.33
Q9N6S8_PLAFA Cysteine proteinase falcipain 2a 1.602e-49 0.44
NK3R_CAVPO TACR3 Neuromedin-K receptor 2.409e-48 0.42
PEPT1_DERPT DERP1 Peptidase 1 5.612e-48 0.39
PAPA1_CARPA Papain 6.851e-48 0.39
KLKB1_HUMAN KLKB1 Plasma kallikrein 5.168e-47 0.40
CASR_HUMAN CASR Extracellular calcium-sensing receptor 8.412e-47 0.35
MRGX1_MOUSE Mrgprx1 Mas-related G-protein coupled receptor member X1 1.446e-46 0.30
C3AR_HUMAN C3AR1 C3a anaphylatoxin chemotactic receptor 1.526e-46 0.38
MMP2_HUMAN MMP2 72 kDa type IV collagenase 1.985e-46 0.48
AMPB_MOUSE Rnpep Aminopeptidase B 4.556e-46 0.37
AMPL_BOVIN LAP3 Cytosol aminopeptidase 4.556e-46 0.37
POLG_HRV14 Genome polyprotein 5.023e-46 0.37
NTR2_HUMAN NTSR2 Neurotensin receptor type 2 8.723e-46 0.31
B3DH72_DANRE oprd1b Opioid receptor, delta 1b 1.569e-45 0.32
O57585_DANRE oprd1a Opioid receptor homologue 1.569e-45 0.32
KLK1_HUMAN KLK1 Kallikrein-1 2.504e-45 0.37
NEP_RAT Mme Neprilysin 2.865e-45 0.38
CBX5_HUMAN CBX5 Chromobox protein homolog 5 9.364e-45 0.36
AMPN_MOUSE Anpep Aminopeptidase N 2.118e-44 0.37
OPRD_HUMAN OPRD1 Delta-type opioid receptor 2.718e-44 0.47
GRPR_RAT Grpr Gastrin-releasing peptide receptor 4.181e-44 0.34
O68720_YERPE yopH Targeted effector protein 7.83e-44 0.38
Q4U254_9ENTO protease Protease 1.076e-43 0.40
AMPB_RAT Rnpep Aminopeptidase B 1.436e-43 0.37
AMPN_HUMAN ANPEP Aminopeptidase N 1.634e-43 0.37
CATK_HUMAN CTSK Cathepsin K 1e-42 0.44
CBX2_HUMAN CBX2 Chromobox protein homolog 2 1.907e-42 0.34
CBX6_HUMAN CBX6 Chromobox protein homolog 6 1.907e-42 0.34
CDY1_HUMAN CDY1; CDY1B Testis-specific chromodomain protein Y 1 1.907e-42 0.34
CDYL_HUMAN CDYL Chromodomain Y-like protein 1.907e-42 0.34
HLAA_HUMAN HLA-A HLA class I histocompatibility antigen, A alpha chain 4.626e-42 0.39
Q98UH1_DANRE oprm1 Mu opioid receptor-like OR2 3.097e-41 0.32
PAR1_HUMAN F2R Proteinase-activated receptor 1 3.309e-41 0.41
SPLB_STAAU splB Serine protease SplB 4.673e-41 0.33
EDNRB_RAT Ednrb Endothelin receptor type B 5.553e-40 0.36
FURIN_HUMAN FURIN Furin 1.172e-39 0.35
Q6IE76_BOVIN FDFT1 FDFT1 protein 1.271e-39 0.31
CAN2_PIG CAPN2 Calpain-2 catalytic subunit 1.467e-39 0.41
ERAP1_HUMAN ERAP1 Endoplasmic reticulum aminopeptidase 1 1.67e-39 0.36
NEC1_HUMAN PCSK1 Neuroendocrine convertase 1 1.699e-39 0.32
PCSK5_HUMAN PCSK5 Proprotein convertase subtilisin/kexin type 5 1.699e-39 0.32
OPRX_MOUSE Oprl1 Nociceptin receptor 2.776e-39 0.31
A0A0C7ACN7_PSEAI pqsD 3-oxoacyl-ACP synthase 4.63e-39 0.32
PEPA_PIG PGA Pepsin A 1.764e-38 0.35
ECE1_BOVIN ECE1 Endothelin-converting enzyme 1 3.134e-38 0.33
ACE_RAT Ace Angiotensin-converting enzyme 3.694e-38 0.38
Q9ERC0_RAT Npy2r Neuropeptide Y receptor Y2 4.562e-38 0.32
MMP9_HUMAN MMP9 Matrix metalloproteinase-9 1.177e-37 0.48
STAT1_MOUSE Stat1 Signal transducer and activator of transcription 1 1.917e-37 0.30
G1FEK8_9CALI Protease 2.134e-37 0.30
I1U3K2_9CALI POL Nonstructural polyprotein 2.134e-37 0.30
EDNRA_MOUSE Ednra Endothelin-1 receptor 6.207e-37 0.35
PSB6_YEAST PRE7 Proteasome subunit beta type-6 6.253e-37 0.29
Q99P97_RAT Histone deacetylase 6 1.332e-36 0.29
NTR1_RAT Ntsr1 Neurotensin receptor type 1 3.097e-36 0.34
CATD_HUMAN CTSD Cathepsin D 3.4e-36 0.36
DPO3B_ECOLI dnaN Beta sliding clamp 3.875e-36 0.29
NTR1_MOUSE Ntsr1 Neurotensin receptor type 1 6.203e-36 0.30
BXA1_CLOBH botA Botulinum neurotoxin type A 6.771e-36 0.30
CATJ_RAT Ctsj Cathepsin J 1.003e-35 0.30
STAT3_HUMAN STAT3 Signal transducer and activator of transcription 3 2.961e-35 0.37
NK2R_CAVPO TACR2 Substance-K receptor 4.499e-35 0.39
CBPA1_HUMAN CPA1 Carboxypeptidase A1 5.593e-35 0.35
NEP_PIG MME Neprilysin 8.164e-35 0.39
CATL1_BOVIN CTSL Cathepsin L1 2.986e-33 0.32
Q8I6Z5_PLAF7 Plasmepsin V 4.345e-33 0.33
GASR_BOVIN CCKBR Gastrin/cholecystokinin type B receptor 8.261e-33 0.31
OPRK_RAT Oprk1 Kappa-type opioid receptor 1.096e-32 0.42
CCKAR_MOUSE Cckar Cholecystokinin receptor type A 1.395e-32 0.33
CATS_HUMAN CTSS Cathepsin S 1.744e-32 0.48
AMD_HUMAN PAM Peptidyl-glycine alpha-amidating monooxygenase 1.77e-32 0.40
MC3R_MOUSE Mc3r Melanocortin receptor 3 2.915e-31 0.32
NK3R_HUMAN TACR3 Neuromedin-K receptor 4.921e-30 0.38
DNPEP_HUMAN DNPEP Aspartyl aminopeptidase 5.245e-30 0.30
CATC_RAT Ctsc Dipeptidyl peptidase 1 9.849e-30 0.30
EDNRA_PIG EDNRA Endothelin-1 receptor 4.34e-29 0.35
S15A2_RAT Slc15a2 Solute carrier family 15 member 2 1.251e-28 0.37
EDNRB_PIG EDNRB Endothelin receptor type B 1.865e-28 0.35
OPRK_CAVPO OPRK1 Kappa-type opioid receptor 6.375e-28 0.43
Q9NAW4_PLAFA Cysteine protease falcipain-3 7.574e-28 0.29
BRCA1_HUMAN BRCA1 Breast cancer type 1 susceptibility protein 8.255e-28 0.31
ACE_RABIT ACE Angiotensin-converting enzyme 8.973e-28 0.38
AMP1_PLAFQ M1 family aminopeptidase 2.1e-27 0.37
MSHR_HUMAN MC1R Melanocyte-stimulating hormone receptor 6.251e-27 0.34
CATL1_RAT Ctsl Cathepsin L1 6.92e-27 0.44
MC3R_HUMAN MC3R Melanocortin receptor 3 3.993e-26 0.31
GASR_HUMAN CCKBR Gastrin/cholecystokinin type B receptor 3.011e-25 0.33
MMEL1_HUMAN MMEL1 Membrane metallo-endopeptidase-like 1 7.658e-25 0.30
Q9NBD4_PLAFA Cysteine protease falcipain-2 1.736e-24 0.30
NMUR1_HUMAN NMUR1 Neuromedin-U receptor 1 2.147e-24 0.38
ITA4_HUMAN ITGA4 Integrin alpha-4 2.283e-24 0.36
MMP7_HUMAN MMP7 Matrilysin 5.421e-24 0.38
Q6DMN0_TOXGO CPL Cathepsin L 7.123e-24 0.44
SSPA_STAAU sspA Glutamyl endopeptidase 1.006e-23 0.35
CATZ_RAT Ctsz Cathepsin Z 3.736e-23 0.28
CMA1_HUMAN CMA1 Chymase 4.894e-23 0.35
OPRM_HUMAN OPRM1 Mu-type opioid receptor 5.643e-23 0.42
LCAP_RAT Lnpep Leucyl-cystinyl aminopeptidase 7.008e-23 0.37
NMUR2_HUMAN NMUR2 Neuromedin-U receptor 2 1.225e-22 0.38
ITB1_HUMAN ITGB1 Integrin beta-1 3.371e-22 0.36
GLUT4_HUMAN SLC2A4 Solute carrier family 2, facilitated glucose transporter member 4 3.578e-22 0.35
PEN2_HUMAN PSENEN Gamma-secretase subunit PEN-2 4.504e-22 0.38
GNPAT_HUMAN GNPAT Dihydroxyacetone phosphate acyltransferase 5.481e-22 0.35
CASP1_HUMAN CASP1 Caspase-1 6.021e-22 0.36
STAT3_MOUSE Stat3 Signal transducer and activator of transcription 3 6.807e-22 0.31
APH1A_HUMAN APH1A Gamma-secretase subunit APH-1A 8.819e-22 0.38
APH1B_HUMAN APH1B Gamma-secretase subunit APH-1B 8.819e-22 0.38
NICA_HUMAN NCSTN Nicastrin 8.819e-22 0.38
PSN2_HUMAN PSEN2 Presenilin-2 9.544e-22 0.38
MRGX1_RAT Mrgprx1 Mas-related G-protein coupled receptor member X1 1.484e-21 0.30
RIR1_MYCTU nrdE Ribonucleoside-diphosphate reductase subunit alpha 2.245e-21 0.34
BRS3_HUMAN BRS3 Bombesin receptor subtype-3 2.426e-21 0.40
MYLK_CHICK Mylk Myosin light chain kinase, smooth muscle 3.273e-21 0.38
AMPB_HUMAN RNPEP Aminopeptidase B 3.574e-21 0.30
PSN1_HUMAN PSEN1 Presenilin-1 5.945e-21 0.38
TRY2_BOVIN Anionic trypsin 6.057e-21 0.34
RENI1_MOUSE Ren1 Renin-1 7.207e-21 0.30
CCKAR_CAVPO CCKAR Cholecystokinin receptor type A 1.501e-20 0.33
Q72874_9HIV1 pol Pol polyprotein 1.85e-20 0.48
MC4R_HUMAN MC4R Melanocortin receptor 4 2.438e-20 0.34
OPRM_MOUSE Oprm1 Mu-type opioid receptor 5.718e-20 0.36
GPC6A_MOUSE Gprc6a G-protein coupled receptor family C group 6 member A 6.33e-20 0.32
MMP17_HUMAN MMP17 Matrix metalloproteinase-17 1.799e-19 0.37
DSBA_ECOLI dsbA Thiol:disulfide interchange protein DsbA 2.124e-19 0.29
CHIA_SERMA chiA Chitinase A 2.44e-19 0.29
PLMN_RAT Plg Plasminogen 3.368e-19 0.36
AMPL_HUMAN LAP3 Cytosol aminopeptidase 5.796e-19 0.36
CATH_HUMAN CTSH Pro-cathepsin H 5.864e-19 0.44
CATH_RAT Ctsh Pro-cathepsin H 1.265e-18 0.30
RENI_MACMU REN Renin 1.641e-18 0.29
ELAS_PSEAE lasB Elastase 1.8e-18 0.33
PSB5_YEAST PRE2 Proteasome subunit beta type-5 2.004e-18 0.29
TRYG1_HUMAN TPSG1 Tryptase gamma 2.576e-18 0.29
Q9YQ12_9HIV1 protease Protease 2.877e-18 0.37
TMPS6_HUMAN TMPRSS6 Transmembrane protease serine 6 3.658e-18 0.35
CASP8_HUMAN CASP8 Caspase-8 3.79e-18 0.36
HMDH_MESAU HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase 3.952e-18 0.29
NEC2_HUMAN PCSK2 Neuroendocrine convertase 2 4.879e-18 0.29
EDNRA_HUMAN EDNRA Endothelin-1 receptor 5.222e-18 0.37
Q94F81_MAIZE hda106 HD2 type histone deacetylase HDA106 5.778e-18 0.35
O07911_STAAU agrC AgrC 1.148e-17 0.34
OPRK_HUMAN OPRK1 Kappa-type opioid receptor 1.448e-17 0.47
CATB_RAT Ctsb Cathepsin B 1.794e-17 0.44
LY96_HUMAN LY96 Lymphocyte antigen 96 1.882e-17 0.33
A5A4K8_RABIT MLNR Motilin receptor 1.999e-17 0.39
CASP9_HUMAN CASP9 Caspase-9 2.009e-17 0.32
PRKDC_HUMAN PRKDC DNA-dependent protein kinase catalytic subunit 1.11e-16 0.36
Q82323_9DELA Protease 1.11e-16 0.29
S15A1_HUMAN SLC15A1 Solute carrier family 15 member 1 1.11e-16 0.32
ECE1_HUMAN ECE1 Endothelin-converting enzyme 1 2.22e-16 0.35
NPY4R_HUMAN NPY4R Neuropeptide Y receptor type 4 2.22e-16 0.34
Q9NBA7_PLAFA Cysteine protease falcipain-3 3.331e-16 0.44
NK1R_HUMAN TACR1 Substance-P receptor 5.551e-16 0.37
NK1R_MOUSE Tacr1 Substance-P receptor 5.551e-16 0.30
V1BR_HUMAN AVPR1B Vasopressin V1b receptor 7.772e-16 0.38
HEPS_HUMAN HPN Serine protease hepsin 1.554e-15 0.34
NK2R_RABIT TACR2 Substance-K receptor 2.442e-15 0.36
GHSR_HUMAN GHSR Growth hormone secretagogue receptor type 1 3.442e-15 0.39
MMP13_HUMAN MMP13 Collagenase 3 4.33e-15 0.43
PCSK6_HUMAN PCSK6 Proprotein convertase subtilisin/kexin type 6 5.662e-15 0.32
KEAP1_HUMAN KEAP1 Kelch-like ECH-associated protein 1 6.217e-15 0.42
LMCPB_LEIME LMCPB Cysteine proteinase B 6.328e-15 0.28
CATK_MOUSE Ctsk Cathepsin K 6.994e-15 0.44
AMPX_VIBPR Bacterial leucyl aminopeptidase 8.105e-15 0.37
XPP1_HUMAN XPNPEP1 Xaa-Pro aminopeptidase 1 1.743e-14 0.32
BACE1_HUMAN BACE1 Beta-secretase 1 2.254e-14 0.38
XIAP_HUMAN XIAP E3 ubiquitin-protein ligase XIAP 2.498e-14 0.38
CD36_RAT Cd36 Platelet glycoprotein 4 2.587e-14 0.29
CCNA2_HUMAN CCNA2 Cyclin-A2 2.809e-14 0.38
CBPA1_BOVIN CPA1 Carboxypeptidase A1 3.186e-14 0.36
DPP4_MOUSE Dpp4 Dipeptidyl peptidase 4 3.475e-14 0.30
TRPV4_HUMAN TRPV4 Transient receptor potential cation channel subfamily V member 4 4.297e-14 0.33
THRB_BOVIN F2 Prothrombin 4.707e-14 0.38
CATL1_MOUSE Ctsl Cathepsin L1 7.905e-14 0.44
CATS_RAT Ctss Cathepsin S 7.905e-14 0.44
PRO_HTL1A gag-pro Gag-Pro polyprotein 1.036e-13 0.29
CASP7_HUMAN CASP7 Caspase-7 1.928e-13 0.36
ENV_HV1H2 env Envelope glycoprotein gp160 2.262e-13 0.29
ECE1_RAT Ece1 Endothelin-converting enzyme 1 2.282e-13 0.30
G3H407_CRIGR PROKR2 3.166e-13 0.31
PCSK7_HUMAN PCSK7 Proprotein convertase subtilisin/kexin type 7 3.922e-13 0.29
CTRA_BOVIN Chymotrypsinogen A 4.224e-13 0.33
Q9YQ30_9PLVG HIV-1 protease HIV-1 protease 5.447e-13 0.30
CATB_MOUSE Ctsb Cathepsin B 5.931e-13 0.44
TS1R1_HUMAN TAS1R1 Taste receptor type 1 member 1 3.93e-12 0.33
BIRC3_HUMAN BIRC3 Baculoviral IAP repeat-containing protein 3 4.28e-12 0.36
ITB7_HUMAN ITGB7 Integrin beta-7 4.869e-12 0.32
UR2R_HUMAN UTS2R Urotensin-2 receptor 4.899e-12 0.31
PTN1_HUMAN PTPN1 Tyrosine-protein phosphatase non-receptor type 1 6.266e-12 0.38
CASP3_HUMAN CASP3 Caspase-3 8.41e-12 0.36
XPP2_RAT Xpnpep2 Xaa-Pro aminopeptidase 2 9.095e-12 0.32
SIR1_HUMAN SIRT1 NAD-dependent protein deacetylase sirtuin-1 1.088e-11 0.35
ANF_HUMAN NPPA Natriuretic peptides A 2.381e-11 0.41
SIR3_HUMAN SIRT3 NAD-dependent protein deacetylase sirtuin-3, mitochondrial 2.638e-11 0.33
CATG_HUMAN CTSG Cathepsin G 3.873e-11 0.33
CCR10_MOUSE Ccr10 C-C chemokine receptor type 10 5.087e-11 0.30
HMDH_HUMAN HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase 5.887e-11 0.34
AOC3_HUMAN AOC3 Membrane primary amine oxidase 8.891e-11 0.31
CCKAR_RAT Cckar Cholecystokinin receptor type A 9.149e-11 0.32
CASP6_HUMAN CASP6 Caspase-6 1.013e-10 0.36
A3EZI9_9HEPC NS3 Genome polyprotein 1.621e-10 0.35
PLM2_PLAFA Plasmepsin-2 1.986e-10 0.34
CARP_RHICH Rhizopuspepsin 3.221e-10 0.32
TRPV4_MOUSE Trpv4 Transient receptor potential cation channel subfamily V member 4 3.382e-10 0.30
XPP2_HUMAN XPNPEP2 Xaa-Pro aminopeptidase 2 4.323e-10 0.32
CCKAR_HUMAN CCKAR Cholecystokinin receptor type A 6.941e-10 0.32
FA10_BOVIN F10 Coagulation factor X 7.745e-10 0.30
CATK_RABIT CTSK Cathepsin K 7.753e-10 0.31
CCND1_HUMAN CCND1 G1/S-specific cyclin-D1 8.795e-10 0.35
MMP14_HUMAN MMP14 Matrix metalloproteinase-14 1.309e-09 0.37
POLG_WNV Genome polyprotein 2.863e-09 0.29
ABCC8_HUMAN ABCC8 ATP-binding cassette sub-family C member 8 4.162e-09 0.29
CATF_HUMAN CTSF Cathepsin F 4.21e-09 0.33
GASR_MOUSE Cckbr Gastrin/cholecystokinin type B receptor 7.594e-09 0.32
PSA_HUMAN NPEPPS Puromycin-sensitive aminopeptidase 8.341e-09 0.37
R1AB_SARS rep Replicase polyprotein 1ab 1.269e-08 0.30
DLG4_HUMAN DLG4 Disks large homolog 4 1.31e-08 0.33
C5AR1_HUMAN C5AR1 C5a anaphylatoxin chemotactic receptor 1 1.326e-08 0.35
EDNRA_RAT Ednra Endothelin-1 receptor 1.424e-08 0.33
SPP2A_HUMAN SPPL2A Signal peptide peptidase-like 2A 2.375e-08 0.33
V1AR_HUMAN AVPR1A Vasopressin V1a receptor 2.455e-08 0.33
CNOT7_HUMAN CNOT7 CCR4-NOT transcription complex subunit 7 3.985e-08 0.29
CASP1_MOUSE Casp1 Caspase-1 6.624e-08 0.32
ACPS_BACSU acpS Holo-[acyl-carrier-protein] synthase 8.647e-08 0.32
BMP1_HUMAN BMP1 Bone morphogenetic protein 1 8.676e-08 0.32
RIR1_HHV11 RIR1 Ribonucleoside-diphosphate reductase large subunit 1.017e-07 0.36
NOD2_HUMAN NOD2 Nucleotide-binding oligomerization domain-containing protein 2 1.084e-07 0.34
PROC_HUMAN PROC Vitamin K-dependent protein C 1.178e-07 0.31
AOC3_RAT Aoc3 Membrane primary amine oxidase 1.204e-07 0.31
TGM2_HUMAN TGM2 Protein-glutamine gamma-glutamyltransferase 2 1.242e-07 0.37
PLMN_HUMAN PLG Plasminogen 1.275e-07 0.34
CYSK_MYCTU cysK1 O-acetylserine sulfhydrylase 1.523e-07 0.34
STAT6_HUMAN STAT6 Signal transducer and activator of transcription 6 1.606e-07 0.30
MRP2_RAT Abcc2 Canalicular multispecific organic anion transporter 1 2.217e-07 0.33
BIRC2_HUMAN BIRC2 Baculoviral IAP repeat-containing protein 2 2.228e-07 0.36
FNTA_BOVIN FNTA Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha 2.429e-07 0.33
HGFA_HUMAN HGFAC Hepatocyte growth factor activator 3.446e-07 0.34
D2K2A8_9HEPC NS4A Non-structural protein 4A 3.636e-07 0.35
GASR_RAT Cckbr Gastrin/cholecystokinin type B receptor 3.936e-07 0.30
PGTB1_BOVIN PGGT1B Geranylgeranyl transferase type-1 subunit beta 4.021e-07 0.32
GP142_MOUSE Gpr142 Probable G-protein coupled receptor 142 5.815e-07 0.28
FNTB_RAT Fntb Protein farnesyltransferase subunit beta 6.864e-07 0.31
SOAT1_HUMAN SOAT1 Sterol O-acyltransferase 1 7.689e-07 0.30
FNTA_RAT Fnta Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha 7.73e-07 0.31
ALBU_HUMAN ALB Serum albumin 9.396e-07 0.29
KLK5_HUMAN KLK5 Kallikrein-5 1.069e-06 0.31
ST14_HUMAN ST14 Suppressor of tumorigenicity 14 protein 1.225e-06 0.34
KCNQ2_MOUSE Kcnq2 Potassium voltage-gated channel subfamily KQT member 2 1.435e-06 0.29
PIN1_HUMAN PIN1 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 1.773e-06 0.31
G3HIE5_CRIGR Prokineticin receptor 1 1.789e-06 0.31
POLG_HCV1 Genome polyprotein 1.911e-06 0.31
LCK_HUMAN LCK Tyrosine-protein kinase Lck 2.227e-06 0.34
HYES_HUMAN EPHX2 Bifunctional epoxide hydrolase 2 2.511e-06 0.38
TYRO_HUMAN TYR Tyrosinase 2.862e-06 0.29
CATS_MOUSE Ctss Cathepsin S 3.5e-06 0.44
ADCY5_RAT Adcy5 Adenylate cyclase type 5 3.64e-06 0.29
DRB3_HUMAN HLA-DRB3 HLA class II histocompatibility antigen, DR beta 3 chain 3.823e-06 0.29
NR1I3_HUMAN NR1I3 Nuclear receptor subfamily 1 group I member 3 3.838e-06 0.29
CNR1_RAT Cnr1 Cannabinoid receptor 1 4.301e-06 0.30
NALD2_HUMAN NAALAD2 N-acetylated-alpha-linked acidic dipeptidase 2 4.687e-06 0.30
THRB_HUMAN F2 Prothrombin 5.894e-06 0.39
SRC_HUMAN SRC Proto-oncogene tyrosine-protein kinase Src 6.395e-06 0.36
TF2AA_HUMAN GTF2A1 Transcription initiation factor IIA subunit 1 6.707e-06 0.29
CTRC_HUMAN CTRC Chymotrypsin-C 8.023e-06 0.32
CP51A_HUMAN CYP51A1 Lanosterol 14-alpha demethylase 8.176e-06 0.28
Q6R7Z5_9TRYP Cathepsin B-like cysteine protease 8.27e-06 0.36
PTGDS_MOUSE Ptgds Prostaglandin-H2 D-isomerase 8.543e-06 0.29
SIR5_HUMAN SIRT5 NAD-dependent protein deacylase sirtuin-5, mitochondrial 9.162e-06 0.31
PCNA_HUMAN PCNA Proliferating cell nuclear antigen 9.349e-06 0.29
CA2D1_RAT Cacna2d1 Voltage-dependent calcium channel subunit alpha-2/delta-1 9.817e-06 0.29

Tofacitinib

JAK3_HUMAN JAK3 Tyrosine-protein kinase JAK3 8.113e-129 1.00
JAK3_RAT Jak3 Tyrosine-protein kinase JAK3 2.9e-124 1.00
JAK1_HUMAN JAK1 Tyrosine-protein kinase JAK1 7.023e-109 1.00
JAK2_HUMAN JAK2 Tyrosine-protein kinase JAK2 1.202e-89 1.00
TYK2_HUMAN TYK2 Non-receptor tyrosine-protein kinase TYK2 7.681e-86 1.00
JAK2_MOUSE Jak2 Tyrosine-protein kinase JAK2 4.629e-39 1.00
JAK3_MOUSE Jak3 Tyrosine-protein kinase JAK3 1.735e-32 1.00
ULK3_HUMAN ULK3 Serine/threonine-protein kinase ULK3 2.976e-21 1.00
DMPK_HUMAN DMPK Myotonin-protein kinase 1.043e-20 1.00
DCLK3_HUMAN DCLK3 Serine/threonine-protein kinase DCLK3 1.016e-19 1.00
GRK7_HUMAN GRK7 Rhodopsin kinase GRK7 7.622e-19 1.00
BMP2K_HUMAN BMP2K BMP-2-inducible protein kinase 4.603e-18 1.00
KS6A6_HUMAN RPS6KA6 Ribosomal protein S6 kinase alpha-6 4.603e-18 1.00
NUAK2_HUMAN NUAK2 NUAK family SNF1-like kinase 2 2.319e-17 1.00
STK4_HUMAN STK4 Serine/threonine-protein kinase 4 1.144e-14 1.00
TNK1_HUMAN TNK1 Non-receptor tyrosine-protein kinase TNK1 1.144e-14 1.00
KCC2A_HUMAN CAMK2A Calcium/calmodulin-dependent protein kinase type II subunit alpha 1.896e-13 1.00
M4K3_HUMAN MAP4K3 Mitogen-activated protein kinase kinase kinase kinase 3 3.137e-13 1.00
KCC1D_HUMAN CAMK1D Calcium/calmodulin-dependent protein kinase type 1D 6.986e-13 1.00
MARK4_HUMAN MARK4 MAP/microtubule affinity-regulating kinase 4 9.469e-13 1.00
PKN1_HUMAN PKN1 Serine/threonine-protein kinase N1 2.589e-12 1.00
SIK2_HUMAN SIK2 Serine/threonine-protein kinase SIK2 6.82e-11 1.00
DCLK1_HUMAN DCLK1 Serine/threonine-protein kinase DCLK1 8.563e-11 1.00
PKNB_MYCTU pknB Serine/threonine-protein kinase PknB 8.563e-11 1.00
ROCK2_HUMAN ROCK2 Rho-associated protein kinase 2 1.016e-10 1.00
KCC1A_HUMAN CAMK1 Calcium/calmodulin-dependent protein kinase type 1 4.372e-09 1.00
KS6A1_HUMAN RPS6KA1 Ribosomal protein S6 kinase alpha-1 1.125e-08 1.00
PKN2_HUMAN PKN2 Serine/threonine-protein kinase N2 4.421e-08 1.00
KPCD_HUMAN PRKCD Protein kinase C delta type 2.654e-07 1.00
STK3_HUMAN STK3 Serine/threonine-protein kinase 3 2.622e-06 1.00
MARK2_HUMAN MARK2 Serine/threonine-protein kinase MARK2 1.045e-05 1.00
FYN_HUMAN FYN Tyrosine-protein kinase Fyn 7.476e-05 1.00
KPCG_HUMAN PRKCG Protein kinase C gamma type 8.099e-05 1.00
KCC2D_HUMAN CAMK2D Calcium/calmodulin-dependent protein kinase type II subunit delta 8.586e-05 1.00
KS6A2_HUMAN RPS6KA2 Ribosomal protein S6 kinase alpha-2 0.0002763 1.00
RET_HUMAN RET Proto-oncogene tyrosine-protein kinase receptor Ret 0.0004626 1.00
SLK_HUMAN SLK STE20-like serine/threonine-protein kinase 0.0004676 1.00
ROCK1_HUMAN ROCK1 Rho-associated protein kinase 1 0.0004964 1.00
M4K5_HUMAN MAP4K5 Mitogen-activated protein kinase kinase kinase kinase 5 0.001452 1.00
CDK8_HUMAN CDK8 Cyclin-dependent kinase 8 0.00149 1.00
M4K2_HUMAN MAP4K2 Mitogen-activated protein kinase kinase kinase kinase 2 0.003192 1.00
LRRK2_HUMAN LRRK2 Leucine-rich repeat serine/threonine-protein kinase 2 0.003337 1.00
MARK3_HUMAN MARK3 MAP/microtubule affinity-regulating kinase 3 0.003768 1.00
MKNK2_HUMAN MKNK2 MAP kinase-interacting serine/threonine-protein kinase 2 0.01655 1.00
LCK_HUMAN LCK Tyrosine-protein kinase Lck 0.03918 1.00
ABL1_HUMAN ABL1 Tyrosine-protein kinase ABL1 0.3824 1.00
AKT2_HUMAN AKT2 RAC-beta serine/threonine-protein kinase 4.288e-25 0.36
CECR2_HUMAN CECR2 Cat eye syndrome critical region protein 2 4.831e-25 0.29
AKT3_HUMAN AKT3 RAC-gamma serine/threonine-protein kinase 1.011e-24 0.36
CCR10_MOUSE Ccr10 C-C chemokine receptor type 10 4.219e-21 0.29
TAF1_HUMAN TAF1 Transcription initiation factor TFIID subunit 1 5.024e-21 0.29
CCR10_HUMAN CCR10 C-C chemokine receptor type 10 2.776e-15 0.29
VRK2_HUMAN VRK2 Serine/threonine-protein kinase VRK2 5.329e-15 0.33
NEK3_HUMAN NEK3 Serine/threonine-protein kinase Nek3 3.487e-12 0.33
M3K15_HUMAN MAP3K15 Mitogen-activated protein kinase kinase kinase 15 1.916e-10 0.33
AKT1_HUMAN AKT1 RAC-alpha serine/threonine-protein kinase 5.09e-10 0.37
BRD9_HUMAN BRD9 Bromodomain-containing protein 9 9.752e-10 0.29
TNI3K_HUMAN TNNI3K Serine/threonine-protein kinase TNNI3K 2.371e-09 0.34
CSKP_HUMAN CASK Peripheral plasma membrane protein CASK 9.077e-09 0.33
MAST1_HUMAN MAST1 Microtubule-associated serine/threonine-protein kinase 1 9.077e-09 0.33
OXSR1_HUMAN OXSR1 Serine/threonine-protein kinase OSR1 9.077e-09 0.33
STK39_HUMAN STK39 STE20/SPS1-related proline-alanine-rich protein kinase 9.077e-09 0.33
DCLK2_HUMAN DCLK2 Serine/threonine-protein kinase DCLK2 2.354e-08 0.33
NEK7_HUMAN NEK7 Serine/threonine-protein kinase Nek7 5.451e-08 0.33
SBK3_HUMAN SBK3 Uncharacterized serine/threonine-protein kinase SBK3 5.451e-08 0.33
SIK3_HUMAN SIK3 Serine/threonine-protein kinase SIK3 5.451e-08 0.33
M3K1_HUMAN MAP3K1 Mitogen-activated protein kinase kinase kinase 1 1.151e-07 0.33
KCC1G_HUMAN CAMK1G Calcium/calmodulin-dependent protein kinase type 1G 4.114e-07 0.33
SBK1_HUMAN SBK1 Serine/threonine-protein kinase SBK1 4.114e-07 0.33
PAK6_HUMAN PAK6 Serine/threonine-protein kinase PAK 6 7.125e-07 0.33
RIPK4_HUMAN RIPK4 Receptor-interacting serine/threonine-protein kinase 4 7.125e-07 0.33
MK08_HUMAN MAPK8 Mitogen-activated protein kinase 8 1.661e-06 0.33
LTK_HUMAN LTK Leukocyte tyrosine kinase receptor 2.744e-06 0.51
KPCT_HUMAN PRKCQ Protein kinase C theta type 2.983e-06 0.33
ANKK1_HUMAN ANKK1 Ankyrin repeat and protein kinase domain-containing protein 1 4.216e-06 0.33
PAK5_HUMAN PAK5 Serine/threonine-protein kinase PAK 5 4.216e-06 0.33
STK25_HUMAN STK25 Serine/threonine-protein kinase 25 6.069e-06 0.33
Q0GMK6_RABIT CDK4 Cyclin-dependent kinase 4 6.522e-06 0.30
RIOK1_HUMAN RIOK1 Serine/threonine-protein kinase RIO1 8.523e-06 0.33
RIOK2_HUMAN RIOK2 Serine/threonine-protein kinase RIO2 8.523e-06 0.33
RIOK3_HUMAN RIOK3 Serine/threonine-protein kinase RIO3 8.523e-06 0.33

Crizotinib

TIE2_MOUSE Tek Angiopoietin-1 receptor 2.9e-124 1.00
SHIP2_HUMAN INPPL1 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 6.113e-85 1.00
M3K12_HUMAN MAP3K12 Mitogen-activated protein kinase kinase kinase 12 1.074e-72 1.00
MET_HUMAN MET Hepatocyte growth factor receptor 3.663e-63 1.00
RON_MOUSE Mst1r Macrophage-stimulating protein receptor 6.524e-44 1.00
M3K15_HUMAN MAP3K15 Mitogen-activated protein kinase kinase kinase 15 3.937e-30 1.00
NEK9_HUMAN NEK9 Serine/threonine-protein kinase Nek9 1.645e-26 1.00
CSKP_HUMAN CASK Peripheral plasma membrane protein CASK 4.419e-25 1.00
M3K7_HUMAN MAP3K7 Mitogen-activated protein kinase kinase kinase 7 5.863e-25 1.00
ALK_HUMAN ALK ALK tyrosine kinase receptor 9.843e-25 1.00
CD11A_HUMAN CDK11A Cyclin-dependent kinase 11A 7.773e-24 1.00
DCLK2_HUMAN DCLK2 Serine/threonine-protein kinase DCLK2 7.773e-24 1.00
RON_HUMAN MST1R Macrophage-stimulating protein receptor 2.111e-23 1.00
COQ8B_HUMAN COQ8B Atypical kinase COQ8B, mitochondrial 9.712e-23 1.00
NEK7_HUMAN NEK7 Serine/threonine-protein kinase Nek7 9.712e-23 1.00
SBK3_HUMAN SBK3 Uncharacterized serine/threonine-protein kinase SBK3 9.712e-23 1.00
M3K13_HUMAN MAP3K13 Mitogen-activated protein kinase kinase kinase 13 1.052e-22 1.00
ABL1_MOUSE Abl1 Tyrosine-protein kinase ABL1 9.163e-22 1.00
M3K1_HUMAN MAP3K1 Mitogen-activated protein kinase kinase kinase 1 9.163e-22 1.00
NIM1_HUMAN NIM1K Serine/threonine-protein kinase NIM1 9.163e-22 1.00
CD11B_HUMAN CDK11B Cyclin-dependent kinase 11B 6.843e-21 1.00
SBK1_HUMAN SBK1 Serine/threonine-protein kinase SBK1 4.197e-20 1.00
RIPK4_HUMAN RIPK4 Receptor-interacting serine/threonine-protein kinase 4 2.176e-19 1.00
INSRR_HUMAN INSRR Insulin receptor-related protein 9.774e-19 1.00
ACVR1_HUMAN ACVR1 Activin receptor type-1 1.876e-18 1.00
DUSTY_HUMAN DSTYK Dual serine/threonine and tyrosine protein kinase 3.874e-18 1.00
TESK1_HUMAN TESK1 Dual specificity testis-specific protein kinase 1 3.874e-18 1.00
ANKK1_HUMAN ANKK1 Ankyrin repeat and protein kinase domain-containing protein 1 4.449e-17 1.00
PI51A_HUMAN PIP5K1A Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha 4.449e-17 1.00
STK35_HUMAN STK35 Serine/threonine-protein kinase 35 4.449e-17 1.00
CDKL2_HUMAN CDKL2 Cyclin-dependent kinase-like 2 1.11e-16 1.00
MUSK_HUMAN MUSK Muscle, skeletal receptor tyrosine-protein kinase 1.11e-16 1.00
RIOK1_HUMAN RIOK1 Serine/threonine-protein kinase RIO1 3.331e-16 1.00
RIOK3_HUMAN RIOK3 Serine/threonine-protein kinase RIO3 3.331e-16 1.00
ULK3_HUMAN ULK3 Serine/threonine-protein kinase ULK3 3.331e-16 1.00
DCLK1_HUMAN DCLK1 Serine/threonine-protein kinase DCLK1 5.551e-16 1.00
DMPK_HUMAN DMPK Myotonin-protein kinase 8.882e-16 1.00
SRPK3_HUMAN SRPK3 SRSF protein kinase 3 8.882e-16 1.00
GRK4_HUMAN GRK4 G protein-coupled receptor kinase 4 2.22e-15 1.00
FES_HUMAN FES Tyrosine-protein kinase Fes/Fps 4.663e-15 1.00
IRAK3_HUMAN IRAK3 Interleukin-1 receptor-associated kinase 3 5.218e-15 1.00
ULK1_HUMAN ULK1 Serine/threonine-protein kinase ULK1 5.218e-15 1.00
EPHA7_HUMAN EPHA7 Ephrin type-A receptor 7 1.144e-14 1.00
MP2K3_HUMAN MAP2K3 Dual specificity mitogen-activated protein kinase kinase 3 1.144e-14 1.00
STK4_HUMAN STK4 Serine/threonine-protein kinase 4 1.144e-14 1.00
TNK1_HUMAN TNK1 Non-receptor tyrosine-protein kinase TNK1 1.144e-14 1.00
ULK2_HUMAN ULK2 Serine/threonine-protein kinase ULK2 1.144e-14 1.00
EPHA5_HUMAN EPHA5 Ephrin type-A receptor 5 2.387e-14 1.00
M3K3_HUMAN MAP3K3 Mitogen-activated protein kinase kinase kinase 3 2.387e-14 1.00
BMP2K_HUMAN BMP2K BMP-2-inducible protein kinase 9.259e-14 1.00
EPHA8_HUMAN EPHA8 Ephrin type-A receptor 8 9.259e-14 1.00
TAOK2_HUMAN TAOK2 Serine/threonine-protein kinase TAO2 9.259e-14 1.00
EPHA4_HUMAN EPHA4 Ephrin type-A receptor 4 3.137e-13 1.00
M4K3_HUMAN MAP4K3 Mitogen-activated protein kinase kinase kinase kinase 3 3.137e-13 1.00
NUAK2_HUMAN NUAK2 NUAK family SNF1-like kinase 2 3.137e-13 1.00
M3K2_HUMAN MAP3K2 Mitogen-activated protein kinase kinase kinase 2 5.523e-13 1.00
STK26_HUMAN STK26 Serine/threonine-protein kinase 26 5.523e-13 1.00
M4K1_HUMAN MAP4K1 Mitogen-activated protein kinase kinase kinase kinase 1 9.469e-13 1.00
EPHA1_HUMAN EPHA1 Ephrin type-A receptor 1 1.584e-12 1.00
EPHB1_HUMAN EPHB1 Ephrin type-B receptor 1 1.584e-12 1.00
ACV1B_HUMAN ACVR1B Activin receptor type-1B 2.589e-12 1.00
EPHA6_HUMAN EPHA6 Ephrin type-A receptor 6 2.589e-12 1.00
BMR1B_HUMAN BMPR1B Bone morphogenetic protein receptor type-1B 4.142e-12 1.00
TSSK2_HUMAN TSSK2 Testis-specific serine/threonine-protein kinase 2 4.142e-12 1.00
TIE1_HUMAN TIE1 Tyrosine-protein kinase receptor Tie-1 1.001e-11 1.00
LTK_HUMAN LTK Leukocyte tyrosine kinase receptor 1.962e-11 1.00
FER_HUMAN FER Tyrosine-protein kinase Fer 2.614e-11 1.00
AAK1_HUMAN AAK1 AP2-associated protein kinase 1 3.307e-11 1.00
EPHB6_HUMAN EPHB6 Ephrin type-B receptor 6 3.307e-11 1.00
SIK2_HUMAN SIK2 Serine/threonine-protein kinase SIK2 6.82e-11 1.00
MK07_HUMAN MAPK7 Mitogen-activated protein kinase 7 9.605e-11 1.00
STK10_HUMAN STK10 Serine/threonine-protein kinase 10 3.375e-10 1.00
EPHA3_HUMAN EPHA3 Ephrin type-A receptor 3 4.504e-10 1.00
ABL2_HUMAN ABL2 Tyrosine-protein kinase ABL2 5.958e-10 1.00
KKCC2_HUMAN CAMKK2 Calcium/calmodulin-dependent protein kinase kinase 2 1.016e-09 1.00
UFO_HUMAN AXL Tyrosine-protein kinase receptor UFO 2.452e-09 1.00
M3K19_HUMAN MAP3K19 Mitogen-activated protein kinase kinase kinase 19 2.698e-09 1.00
TXK_HUMAN TXK Tyrosine-protein kinase TXK 3.385e-09 1.00
8ODP_HUMAN NUDT1 7,8-dihydro-8-oxoguanine triphosphatase 6.454e-09 1.00
NTRK2_HUMAN NTRK2 BDNF/NT-3 growth factors receptor 7.431e-09 1.00
ROS1_HUMAN ROS1 Proto-oncogene tyrosine-protein kinase ROS 2.33e-08 1.00
RIPK2_HUMAN RIPK2 Receptor-interacting serine/threonine-protein kinase 2 2.428e-08 1.00
E2AK2_HUMAN EIF2AK2 Interferon-induced, double-stranded RNA-activated protein kinase 3.408e-08 1.00
FGR_HUMAN FGR Tyrosine-protein kinase Fgr 4.014e-08 1.00
NTRK3_HUMAN NTRK3 NT-3 growth factor receptor 1.39e-07 1.00
FRK_HUMAN FRK Tyrosine-protein kinase FRK 1.643e-07 1.00
IRAK1_HUMAN IRAK1 Interleukin-1 receptor-associated kinase 1 2.533e-07 1.00
AURKC_HUMAN AURKC Aurora kinase C 3.618e-07 1.00
EPHA2_HUMAN EPHA2 Ephrin type-A receptor 2 3.847e-07 1.00
MINK1_HUMAN MINK1 Misshapen-like kinase 1 2.111e-06 1.00
BLK_HUMAN BLK Tyrosine-protein kinase Blk 2.234e-06 1.00
TAOK3_HUMAN TAOK3 Serine/threonine-protein kinase TAO3 2.404e-06 1.00
STK3_HUMAN STK3 Serine/threonine-protein kinase 3 2.996e-06 1.00
SLK_HUMAN SLK STE20-like serine/threonine-protein kinase 4.684e-06 1.00
M4K5_HUMAN MAP4K5 Mitogen-activated protein kinase kinase kinase kinase 5 4.946e-06 1.00
BMX_HUMAN BMX Cytoplasmic tyrosine-protein kinase BMX 5.715e-06 1.00
FAK2_HUMAN PTK2B Protein-tyrosine kinase 2-beta 7.872e-06 1.00
KPCD3_HUMAN PRKD3 Serine/threonine-protein kinase D3 9.339e-06 1.00
KPCD1_HUMAN PRKD1 Serine/threonine-protein kinase D1 9.927e-06 1.00
AAPK1_HUMAN PRKAA1 5'-AMP-activated protein kinase catalytic subunit alpha-1 1.077e-05 1.00
PHKG2_HUMAN PHKG2 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 1.363e-05 1.00
LYN_HUMAN LYN Tyrosine-protein kinase Lyn 1.384e-05 1.00
DDR1_HUMAN DDR1 Epithelial discoidin domain-containing receptor 1 1.54e-05 1.00
TYRO3_HUMAN TYRO3 Tyrosine-protein kinase receptor TYRO3 1.776e-05 1.00
YES_HUMAN YES1 Tyrosine-protein kinase Yes 2.06e-05 1.00
CDK7_HUMAN CDK7 Cyclin-dependent kinase 7 2.579e-05 1.00
IKKE_HUMAN IKBKE Inhibitor of nuclear factor kappa-B kinase subunit epsilon 3.093e-05 1.00
TGFR1_HUMAN TGFBR1 TGF-beta receptor type-1 3.441e-05 1.00
PLK4_HUMAN PLK4 Serine/threonine-protein kinase PLK4 3.579e-05 1.00
TAOK1_HUMAN TAOK1 Serine/threonine-protein kinase TAO1 4.959e-05 1.00
FLT3_HUMAN FLT3 Receptor-type tyrosine-protein kinase FLT3 5.584e-05 1.00
LIMK1_HUMAN LIMK1 LIM domain kinase 1 5.855e-05 1.00
TBK1_HUMAN TBK1 Serine/threonine-protein kinase TBK1 6.204e-05 1.00
RIPK1_HUMAN RIPK1 Receptor-interacting serine/threonine-protein kinase 1 6.503e-05 1.00
ACK1_HUMAN TNK2 Activated CDC42 kinase 1 8.23e-05 1.00
DYRK2_HUMAN DYRK2 Dual specificity tyrosine-phosphorylation-regulated kinase 2 8.415e-05 1.00
NEK4_HUMAN NEK4 Serine/threonine-protein kinase Nek4 9.519e-05 1.00
RET_HUMAN RET Proto-oncogene tyrosine-protein kinase receptor Ret 9.81e-05 1.00
M4K2_HUMAN MAP4K2 Mitogen-activated protein kinase kinase kinase kinase 2 9.898e-05 1.00
TNI3K_HUMAN TNNI3K Serine/threonine-protein kinase TNNI3K 0.0001073 1.00
VGFR3_HUMAN FLT4 Vascular endothelial growth factor receptor 3 0.0001204 1.00
M3K20_HUMAN MAP3K20 Mitogen-activated protein kinase kinase kinase 20 0.0003039 1.00
ZAP70_HUMAN ZAP70 Tyrosine-protein kinase ZAP-70 0.000323 1.00
SRPK1_HUMAN SRPK1 SRSF protein kinase 1 0.0003531 1.00
LIMK2_HUMAN LIMK2 LIM domain kinase 2 0.0003853 1.00
MERTK_HUMAN MERTK Tyrosine-protein kinase Mer 0.0008578 1.00
INSR_HUMAN INSR Insulin receptor 0.0009214 1.00
FGFR3_HUMAN FGFR3 Fibroblast growth factor receptor 3 0.0009578 1.00
KPCD2_HUMAN PRKD2 Serine/threonine-protein kinase D2 0.001193 1.00
MARK2_HUMAN MARK2 Serine/threonine-protein kinase MARK2 0.001221 1.00
HIPK4_HUMAN HIPK4 Homeodomain-interacting protein kinase 4 0.001952 1.00
VGFR1_HUMAN FLT1 Vascular endothelial growth factor receptor 1 0.002125 1.00
ABL1_HUMAN ABL1 Tyrosine-protein kinase ABL1 0.002139 1.00
PKN2_HUMAN PKN2 Serine/threonine-protein kinase N2 0.002625 1.00
ITK_HUMAN ITK Tyrosine-protein kinase ITK/TSK 0.003022 1.00
EPHB4_HUMAN EPHB4 Ephrin type-B receptor 4 0.003427 1.00
CSF1R_HUMAN CSF1R Macrophage colony-stimulating factor 1 receptor 0.003471 1.00
MARK3_HUMAN MARK3 MAP/microtubule affinity-regulating kinase 3 0.003768 1.00
KS6B1_HUMAN RPS6KB1 Ribosomal protein S6 kinase beta-1 0.00828 1.00
FYN_HUMAN FYN Tyrosine-protein kinase Fyn 0.01089 1.00
AURKB_HUMAN AURKB Aurora kinase B 0.0196 1.00
FAK1_HUMAN PTK2 Focal adhesion kinase 1 0.02426 1.00
LCK_HUMAN LCK Tyrosine-protein kinase Lck 0.02831 1.00
NTRK1_HUMAN NTRK1 High affinity nerve growth factor receptor 0.03178 1.00
SRC_HUMAN SRC Proto-oncogene tyrosine-protein kinase Src 0.04763 1.00
TIE2_HUMAN TEK Angiopoietin-1 receptor 0.07698 1.00
FGFR1_HUMAN FGFR1 Fibroblast growth factor receptor 1 0.09283 1.00
TYK2_HUMAN TYK2 Non-receptor tyrosine-protein kinase TYK2 0.1084 1.00
IKKB_HUMAN IKBKB Inhibitor of nuclear factor kappa-B kinase subunit beta 0.1488 1.00
AURKA_HUMAN AURKA Aurora kinase A 0.1518 1.00
IGF1R_HUMAN IGF1R Insulin-like growth factor 1 receptor 0.2002 1.00
IRAK4_HUMAN IRAK4 Interleukin-1 receptor-associated kinase 4 0.2069 1.00
JAK2_HUMAN JAK2 Tyrosine-protein kinase JAK2 0.2135 1.00
LRRK2_HUMAN LRRK2 Leucine-rich repeat serine/threonine-protein kinase 2 0.2339 1.00
JAK1_HUMAN JAK1 Tyrosine-protein kinase JAK1 0.253 1.00
JAK3_HUMAN JAK3 Tyrosine-protein kinase JAK3 0.2881 1.00
CDK5_HUMAN CDK5 Cyclin-dependent-like kinase 5 0.3149 1.00
KIT_HUMAN KIT Mast/stem cell growth factor receptor Kit 0.3884 1.00
ROCK1_HUMAN ROCK1 Rho-associated protein kinase 1 0.3948 1.00
CDK1_HUMAN CDK1 Cyclin-dependent kinase 1 0.4293 1.00
VGFR2_HUMAN KDR Vascular endothelial growth factor receptor 2 0.5665 1.00
KSYK_HUMAN SYK Tyrosine-protein kinase SYK 0.6079 1.00
BTK_HUMAN BTK Tyrosine-protein kinase BTK 0.7268 1.00
ROCK2_HUMAN ROCK2 Rho-associated protein kinase 2 0.7699 1.00
EGFR_HUMAN EGFR Epidermal growth factor receptor 0.9167 1.00
CDK2_HUMAN CDK2 Cyclin-dependent kinase 2 0.9625 1.00
GRK5_HUMAN GRK5 G protein-coupled receptor kinase 5 3.228e-86 0.44
ARBK1_HUMAN GRK2 Beta-adrenergic receptor kinase 1 2.067e-44 0.43
TAB1_HUMAN TAB1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 1.775e-32 0.39
PAK1_HUMAN PAK1 Serine/threonine-protein kinase PAK 1 1.517e-29 0.43
M3K12_MOUSE Map3k12 Mitogen-activated protein kinase kinase kinase 12 1.174e-24 0.30
ACHB2_HUMAN CHRNB2 Neuronal acetylcholine receptor subunit beta-2 1.246e-06 0.45
ACHA4_HUMAN CHRNA4 Neuronal acetylcholine receptor subunit alpha-4 2.315e-06 0.45

Pomalidomide

IKZF1_HUMAN IKZF1 DNA-binding protein Ikaros 1.24e-119 1.00
CRBN_HUMAN CRBN Protein cereblon 2.94e-99 1.00
MEP2_YEAST MEP2 Ammonium transporter MEP2 8.108e-12 0.35
FIBB_HUMAN FGB Fibrinogen beta chain 3.542e-11 0.30
Q5J463_SALCH tem-1 Beta-lactamase 4.119e-11 0.31
GLD1_CAEEL gld-1 Female germline-specific tumor suppressor gld-1 6.79e-10 0.38
GLF_MYCTU glf UDP-galactopyranose mutase 2.182e-08 0.31

Linagliptin

DPP4_HUMAN DPP4 Dipeptidyl peptidase 4 9.209e-110 1.00
SEPR_HUMAN FAP Prolyl endopeptidase FAP 3.352e-36 1.00
O31048_PORGN DPP IV Dipeptidyl peptidase IV 2.68e-35 1.00
SEPR_MOUSE Fap Prolyl endopeptidase FAP 2.631e-11 1.00
ACM1_HUMAN CHRM1 Muscarinic acetylcholine receptor M1 1.915e-10 1.00
Q8MHZ5_SHEEP Ghrelin/growth hormone secretagogue receptor 1.56e-44 0.34
DPP4_BOVIN DPP4 Dipeptidyl peptidase 4 3.636e-31 0.39
DPP4_PIG DPP4 Dipeptidyl peptidase 4 2.267e-28 0.56
PADI4_HUMAN PADI4 Protein-arginine deiminase type-4 9.385e-26 0.31
AA2AR_RAT Adora2a Adenosine receptor A2a 5.14e-24 0.40
AA1R_RAT Adora1 Adenosine receptor A1 1.332e-15 0.40
AL1A1_HUMAN ALDH1A1 Retinal dehydrogenase 1 6.817e-14 0.33
DPP4_RAT Dpp4 Dipeptidyl peptidase 4 1.348e-09 0.54
PDE6D_HUMAN PDE6D Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta 2.553e-08 0.31
5HT3B_RAT Htr3b 5-hydroxytryptamine receptor 3B 3.772e-07 0.32
MDR1B_MOUSE Abcb1b ATP-dependent translocase ABCB1 7.513e-06 0.29

Ponatinib

ABL1_HUMAN ABL1 Tyrosine-protein kinase ABL1 5.333e-108 1.00
KIT_HUMAN KIT Mast/stem cell growth factor receptor Kit 2.557e-77 1.00
LYN_HUMAN LYN Tyrosine-protein kinase Lyn 3.37e-31 1.00
SRC_HUMAN SRC Proto-oncogene tyrosine-protein kinase Src 7.188e-24 1.00
PGFRA_HUMAN PDGFRA Platelet-derived growth factor receptor alpha 3.173e-23 1.00
VGFR2_HUMAN KDR Vascular endothelial growth factor receptor 2 1.408e-22 1.00
PGFRB_HUMAN PDGFRB Platelet-derived growth factor receptor beta 8.266e-22 1.00
RET_HUMAN RET Proto-oncogene tyrosine-protein kinase receptor Ret 2.23e-18 1.00
FGFR1_HUMAN FGFR1 Fibroblast growth factor receptor 1 1.028e-11 1.00
RIPK2_HUMAN RIPK2 Receptor-interacting serine/threonine-protein kinase 2 3.225e-11 1.00
FLT3_HUMAN FLT3 Receptor-type tyrosine-protein kinase FLT3 4.076e-09 1.00
FGFR3_HUMAN FGFR3 Fibroblast growth factor receptor 3 9.431e-07 1.00
SRC_CHICK SRC Proto-oncogene tyrosine-protein kinase Src 2.194e-06 1.00
FGFR2_HUMAN FGFR2 Fibroblast growth factor receptor 2 0.0001064 1.00
FGFR4_HUMAN FGFR4 Fibroblast growth factor receptor 4 0.0003673 1.00
A1Z199_HUMAN BCR/ABL fusion BCR/ABL p210 fusion protein 9.286e-203 0.56
DDR1_HUMAN DDR1 Epithelial discoidin domain-containing receptor 1 2.118e-138 0.59
BRAF_HUMAN BRAF Serine/threonine-protein kinase B-raf 6.205e-101 0.65
DDR2_HUMAN DDR2 Discoidin domain-containing receptor 2 5.078e-98 0.61
ABL2_HUMAN ABL2 Tyrosine-protein kinase ABL2 1.213e-75 0.95
ACKR3_HUMAN ACKR3 Atypical chemokine receptor 3 4.729e-56 0.36
RAF1_HUMAN RAF1 RAF proto-oncogene serine/threonine-protein kinase 4.288e-55 0.61
NR2C2_HUMAN NR2C2 Nuclear receptor subfamily 2 group C member 2 8.588e-49 0.61
TIE2_HUMAN TEK Angiopoietin-1 receptor 4.021e-41 0.65
ARAF_HUMAN ARAF Serine/threonine-protein kinase A-Raf 1.96e-34 0.41
FAK1_HUMAN PTK2 Focal adhesion kinase 1 5.806e-31 0.33
LCK_HUMAN LCK Tyrosine-protein kinase Lck 2.826e-30 0.53
ABL1_MOUSE Abl1 Tyrosine-protein kinase ABL1 1.646e-28 0.40
EPHA3_HUMAN EPHA3 Ephrin type-A receptor 3 7.565e-27 0.65
MK14_HUMAN MAPK14 Mitogen-activated protein kinase 14 1.384e-22 0.73
MKNK1_HUMAN MKNK1 MAP kinase-interacting serine/threonine-protein kinase 1 7.242e-22 0.42
BMX_HUMAN BMX Cytoplasmic tyrosine-protein kinase BMX 1.34e-21 0.47
HSPB1_HUMAN HSPB1 Heat shock protein beta-1 2.385e-21 0.30
CSF1R_HUMAN CSF1R Macrophage colony-stimulating factor 1 receptor 8.033e-21 0.58
PGFRB_RAT Pdgfrb Platelet-derived growth factor receptor beta 3.871e-20 0.40
EPHA8_HUMAN EPHA8 Ephrin type-A receptor 8 2.148e-19 0.40
PIR_HUMAN PIR Pirin 2.474e-19 0.30
5HT1F_HUMAN HTR1F 5-hydroxytryptamine receptor 1F 4.656e-19 0.34
EPHB2_HUMAN EPHB2 Ephrin type-B receptor 2 1.156e-18 0.61
OXYR_MOUSE Oxtr Oxytocin receptor 6.925e-18 0.28
KDM1B_HUMAN KDM1B Lysine-specific histone demethylase 1B 8.683e-18 0.28
PRIO_SHEEP PRNP Major prion protein 1.282e-17 0.29
PGFRA_MOUSE Pdgfra Platelet-derived growth factor receptor alpha 1.788e-17 0.40
CDKL1_HUMAN CDKL1 Cyclin-dependent kinase-like 1 1.11e-16 0.37
ROCK2_HUMAN ROCK2 Rho-associated protein kinase 2 1.11e-16 0.37
HCK_HUMAN HCK Tyrosine-protein kinase HCK 1.998e-15 0.40
M3K6_HUMAN MAP3K6 Mitogen-activated protein kinase kinase kinase 6 5.218e-15 0.37
MET_HUMAN MET Hepatocyte growth factor receptor 5.44e-15 0.37
EPHA7_HUMAN EPHA7 Ephrin type-A receptor 7 5.551e-15 0.65
FGR_HUMAN FGR Tyrosine-protein kinase Fgr 5.995e-15 0.47
5HT1D_CAVPO HTR1D 5-hydroxytryptamine receptor 1D 2.593e-13 0.30
GRK5_BOVIN GRK5 G protein-coupled receptor kinase 5 4.508e-13 0.28
YES_HUMAN YES1 Tyrosine-protein kinase Yes 7.395e-13 0.61
CDKL3_HUMAN CDKL3 Cyclin-dependent kinase-like 3 1.48e-12 0.37
EPHA4_HUMAN EPHA4 Ephrin type-A receptor 4 1.632e-12 0.37
S47A2_HUMAN SLC47A2 Multidrug and toxin extrusion protein 2 1.829e-12 0.40
BLK_HUMAN BLK Tyrosine-protein kinase Blk 2.109e-12 0.61
RIOK2_HUMAN RIOK2 Serine/threonine-protein kinase RIO2 2.555e-12 0.38
VGFR1_HUMAN FLT1 Vascular endothelial growth factor receptor 1 7.071e-12 0.65
MAK_HUMAN MAK Serine/threonine-protein kinase MAK 1.12e-11 0.37
SL9A1_RAT Slc9a1 Sodium/hydrogen exchanger 1 1.702e-11 0.30
CDPK1_PLAF7 CPK1 Calcium-dependent protein kinase 1 4.329e-11 0.37
KAPCB_HUMAN PRKACB cAMP-dependent protein kinase catalytic subunit beta 6.043e-11 0.37
ST38L_HUMAN STK38L Serine/threonine-protein kinase 38-like 6.043e-11 0.37
MKNK2_HUMAN MKNK2 MAP kinase-interacting serine/threonine-protein kinase 2 8.763e-11 0.42
NEK9_HUMAN NEK9 Serine/threonine-protein kinase Nek9 2.523e-10 0.37
DGAT1_MOUSE Dgat1 Diacylglycerol O-acyltransferase 1 3.11e-10 0.31
TRPV1_HUMAN TRPV1 Transient receptor potential cation channel subfamily V member 1 4.059e-10 0.37
CDKL5_HUMAN CDKL5 Cyclin-dependent kinase-like 5 8.634e-10 0.37
KCC4_HUMAN CAMK4 Calcium/calmodulin-dependent protein kinase type IV 8.634e-10 0.37
MYO3A_HUMAN MYO3A Myosin-IIIa 8.634e-10 0.37
STK39_HUMAN STK39 STE20/SPS1-related proline-alanine-rich protein kinase 8.634e-10 0.37
EPHA5_HUMAN EPHA5 Ephrin type-A receptor 5 1.311e-09 0.37
CD11A_HUMAN CDK11A Cyclin-dependent kinase 11A 2.524e-09 0.37
CDK13_HUMAN CDK13 Cyclin-dependent kinase 13 2.524e-09 0.37
MYO3B_HUMAN MYO3B Myosin-IIIb 2.524e-09 0.37
RON_HUMAN MST1R Macrophage-stimulating protein receptor 2.704e-09 0.37
DCNL1_HUMAN DCUN1D1 DCN1-like protein 1 3.828e-09 0.31
NEK5_HUMAN NEK5 Serine/threonine-protein kinase Nek5 6.497e-09 0.37
M4K1_HUMAN MAP4K1 Mitogen-activated protein kinase kinase kinase kinase 1 1.473e-08 0.37
M3K1_HUMAN MAP3K1 Mitogen-activated protein kinase kinase kinase 1 1.506e-08 0.37
EPHA1_HUMAN EPHA1 Ephrin type-A receptor 1 2.066e-08 0.37
EPHB1_HUMAN EPHB1 Ephrin type-B receptor 1 2.066e-08 0.37
EGFR_HUMAN EGFR Epidermal growth factor receptor 2.08e-08 0.65
MK03_MOUSE Mapk3 Mitogen-activated protein kinase 3 2.476e-08 0.32
EPHA6_HUMAN EPHA6 Ephrin type-A receptor 6 2.854e-08 0.37
CD11B_HUMAN CDK11B Cyclin-dependent kinase 11B 3.2e-08 0.37
CDK15_HUMAN CDK15 Cyclin-dependent kinase 15 3.2e-08 0.37
LATS1_HUMAN LATS1 Serine/threonine-protein kinase LATS1 3.2e-08 0.37
SGK3_HUMAN SGK3 Serine/threonine-protein kinase Sgk3 3.2e-08 0.37
GSK3B_MOUSE Gsk3b Glycogen synthase kinase-3 beta 3.549e-08 0.30
EFC4B_HUMAN CRACR2A EF-hand calcium-binding domain-containing protein 4B 3.627e-08 0.29
INSR_HUMAN INSR Insulin receptor 5.984e-08 0.37
AVR2B_HUMAN ACVR2B Activin receptor type-2B 6.318e-08 0.37
CDK18_HUMAN CDK18 Cyclin-dependent kinase 18 6.318e-08 0.37
STK24_HUMAN STK24 Serine/threonine-protein kinase 24 6.318e-08 0.37
TIE1_HUMAN TIE1 Tyrosine-protein kinase receptor Tie-1 6.948e-08 0.37
PGFRB_MOUSE Pdgfrb Platelet-derived growth factor receptor beta 7.385e-08 0.40
NEK6_HUMAN NEK6 Serine/threonine-protein kinase Nek6 1.172e-07 0.37
RIPK4_HUMAN RIPK4 Receptor-interacting serine/threonine-protein kinase 4 1.172e-07 0.37
TBK1_HUMAN TBK1 Serine/threonine-protein kinase TBK1 1.174e-07 0.38
5HT2A_HUMAN HTR2A 5-hydroxytryptamine receptor 2A 1.447e-07 0.40
IKKE_HUMAN IKBKE Inhibitor of nuclear factor kappa-B kinase subunit epsilon 1.673e-07 0.38
CILK1_HUMAN CILK1 Serine/threonine-protein kinase ICK 2.06e-07 0.37
INSRR_HUMAN INSRR Insulin receptor-related protein 2.06e-07 0.37
TEC_HUMAN TEC Tyrosine-protein kinase Tec 2.3e-07 0.28
TA2R8_HUMAN TAS2R8 Taste receptor type 2 member 8 2.686e-07 0.30
MRCKB_HUMAN CDC42BPB Serine/threonine-protein kinase MRCK beta 2.905e-07 0.28
CDK14_HUMAN CDK14 Cyclin-dependent kinase 14 3.457e-07 0.37
DUSTY_HUMAN DSTYK Dual serine/threonine and tyrosine protein kinase 3.457e-07 0.37
LATS2_HUMAN LATS2 Serine/threonine-protein kinase LATS2 3.457e-07 0.37
TESK1_HUMAN TESK1 Dual specificity testis-specific protein kinase 1 3.457e-07 0.37
SHH_MOUSE Shh Sonic hedgehog protein 3.588e-07 0.38
MP2K5_HUMAN MAP2K5 Dual specificity mitogen-activated protein kinase kinase 5 4.728e-07 0.37
M4K2_HUMAN MAP4K2 Mitogen-activated protein kinase kinase kinase kinase 2 4.804e-07 0.37
CDK17_HUMAN CDK17 Cyclin-dependent kinase 17 5.569e-07 0.37
M3K13_HUMAN MAP3K13 Mitogen-activated protein kinase kinase kinase 13 5.569e-07 0.37
IRAK4_HUMAN IRAK4 Interleukin-1 receptor-associated kinase 4 6.416e-07 0.34
STK10_HUMAN STK10 Serine/threonine-protein kinase 10 7.054e-07 0.37
S22A2_HUMAN SLC22A2 Solute carrier family 22 member 2 7.353e-07 0.40
HSF1_HUMAN HSF1 Heat shock factor protein 1 7.853e-07 0.31
5HT2C_HUMAN HTR2C 5-hydroxytryptamine receptor 2C 8.177e-07 0.35
ANKK1_HUMAN ANKK1 Ankyrin repeat and protein kinase domain-containing protein 1 8.658e-07 0.37
STK35_HUMAN STK35 Serine/threonine-protein kinase 35 8.658e-07 0.37
CDKL2_HUMAN CDKL2 Cyclin-dependent kinase-like 2 1.304e-06 0.37
MUSK_HUMAN MUSK Muscle, skeletal receptor tyrosine-protein kinase 1.304e-06 0.37
STK25_HUMAN STK25 Serine/threonine-protein kinase 25 1.304e-06 0.37
KKCC2_HUMAN CAMKK2 Calcium/calmodulin-dependent protein kinase kinase 2 1.468e-06 0.37
S47A1_HUMAN SLC47A1 Multidrug and toxin extrusion protein 1 1.54e-06 0.40
FRK_HUMAN FRK Tyrosine-protein kinase FRK 1.738e-06 0.40
KKCC1_HUMAN CAMKK1 Calcium/calmodulin-dependent protein kinase kinase 1 1.91e-06 0.37
STK36_HUMAN STK36 Serine/threonine-protein kinase 36 1.91e-06 0.37
ULK3_HUMAN ULK3 Serine/threonine-protein kinase ULK3 1.91e-06 0.37
LDLR_HUMAN LDLR Low-density lipoprotein receptor 2.185e-06 0.29
BTK_HUMAN BTK Tyrosine-protein kinase BTK 2.259e-06 0.61
MK11_HUMAN MAPK11 Mitogen-activated protein kinase 11 2.496e-06 0.37
MYLK2_HUMAN MYLK2 Myosin light chain kinase 2, skeletal/cardiac muscle 3.811e-06 0.37
TNIK_HUMAN TNIK TRAF2 and NCK-interacting protein kinase 4.16e-06 0.37
FYN_HUMAN FYN Tyrosine-protein kinase Fyn 4.169e-06 0.61
CAH3_HUMAN CA3 Carbonic anhydrase 3 4.463e-06 0.40
PI42C_HUMAN PIP4K2C Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma 4.463e-06 0.40
MCHR1_HUMAN MCHR1 Melanin-concentrating hormone receptor 1 4.87e-06 0.32
MK15_HUMAN MAPK15 Mitogen-activated protein kinase 15 5.215e-06 0.37
ULK1_HUMAN ULK1 Serine/threonine-protein kinase ULK1 5.215e-06 0.37
M3K20_HUMAN MAP3K20 Mitogen-activated protein kinase kinase kinase 20 6.808e-06 0.40
MP2K3_HUMAN MAP2K3 Dual specificity mitogen-activated protein kinase kinase 3 7.008e-06 0.37
STK4_HUMAN STK4 Serine/threonine-protein kinase 4 7.008e-06 0.37
TNK1_HUMAN TNK1 Non-receptor tyrosine-protein kinase TNK1 7.008e-06 0.37
ULK2_HUMAN ULK2 Serine/threonine-protein kinase ULK2 7.008e-06 0.37
5HT2B_HUMAN HTR2B 5-hydroxytryptamine receptor 2B 8.406e-06 0.32
MP2K4_HUMAN MAP2K4 Dual specificity mitogen-activated protein kinase kinase 4 9.261e-06 0.37
PAK3_HUMAN PAK3 Serine/threonine-protein kinase PAK 3 9.261e-06 0.37

Enzalutamide

ANDR_HUMAN AR Androgen receptor 9.777e-108 1.00
ANDR_RAT Ar Androgen receptor 2.799e-37 1.00
PRGR_RAT Pgr Progesterone receptor 1.088e-14 0.32
ELNE_HUMAN ELANE Neutrophil elastase 1.376e-09 0.34
PK3CD_MOUSE Pik3cd Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 1.359e-06 0.29

Aclidinium

ACM3_HUMAN CHRM3 Muscarinic acetylcholine receptor M3 4.226e-100 1.00
ACM2_HUMAN CHRM2 Muscarinic acetylcholine receptor M2 6.648e-36 1.00
ACM1_HUMAN CHRM1 Muscarinic acetylcholine receptor M1 6.011e-32 1.00
ACM4_HUMAN CHRM4 Muscarinic acetylcholine receptor M4 0.0002942 1.00
ACM5_HUMAN CHRM5 Muscarinic acetylcholine receptor M5 0.0003129 1.00
Q8WMX0_BOVIN Muscarinic receptor M1 5.947e-64 0.38
Q8VH26_CAVPO GPM3 Muscarinic acetylcholine receptor 3.037e-28 0.51
Q6RY99_RAT Tetraspanin 8.524e-21 0.30
ACM2_RAT Chrm2 Muscarinic acetylcholine receptor M2 3.072e-19 0.46
LPXC_AQUAE lpxC UDP-3-O-acyl-N-acetylglucosamine deacetylase 1.577e-10 0.28
HRH3_CAVPO HRH3 Histamine H3 receptor 1.173e-09 0.30
ACM1_DROME mAChR-A Muscarinic acetylcholine receptor DM1 1.498e-09 0.38
ACM3_RAT Chrm3 Muscarinic acetylcholine receptor M3 4.401e-09 0.43
FPPS_HUMAN FDPS Farnesyl pyrophosphate synthase 1.983e-07 0.30

Ifenprodil

NMDE2_RAT Grin2b Glutamate receptor ionotropic, NMDA 2B 1.848e-97 1.00
NMDE2_HUMAN GRIN2B Glutamate receptor ionotropic, NMDA 2B 3.151e-63 1.00
SGMR2_RAT Tmem97 Sigma intracellular receptor 2 4.605e-39 1.00
SC6A3_RAT Slc6a3 Sodium-dependent dopamine transporter 7.112e-36 1.00
SGMR1_CAVPO SIGMAR1 Sigma non-opioid intracellular receptor 1 9.366e-34 1.00
NMDZ1_HUMAN GRIN1 Glutamate receptor ionotropic, NMDA 1 1.812e-27 1.00
NMDE3_RAT Grin2c Glutamate receptor ionotropic, NMDA 2C 2.917e-20 1.00
NMDZ1_RAT Grin1 Glutamate receptor ionotropic, NMDA 1 1.332e-15 1.00
SGMR1_HUMAN SIGMAR1 Sigma non-opioid intracellular receptor 1 4.996e-15 1.00
ERG2_YEAST ERG2 C-8 sterol isomerase 9.469e-13 1.00
EBP_HUMAN EBP 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase 6.82e-11 1.00
SGMR1_RAT Sigmar1 Sigma non-opioid intracellular receptor 1 4.9e-10 1.00
5HT2A_BOVIN HTR2A 5-hydroxytryptamine receptor 2A 1.415e-08 1.00
5HT1A_MOUSE Htr1a 5-hydroxytryptamine receptor 1A 1.702e-08 1.00
CP2D6_HUMAN CYP2D6 Cytochrome P450 2D6 1.029e-06 1.00
EBP_CAVPO EBP 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase 2.844e-06 1.00
HRH1_HUMAN HRH1 Histamine H1 receptor 0.001026 1.00
KCNH2_HUMAN KCNH2 Potassium voltage-gated channel subfamily H member 2 0.01569 1.00
ADA1A_HUMAN ADRA1A Alpha-1A adrenergic receptor 0.08103 1.00
DCNL1_HUMAN DCUN1D1 DCN1-like protein 1 9.115e-72 0.37
Q8CGM4_CAVPO OPRM1 Mu-opioid receptor 2.206e-69 0.33
NMD3A_RAT Grin3a Glutamate receptor ionotropic, NMDA 3A 4.824e-68 0.49
VMAT2_RAT Slc18a2 Synaptic vesicular amine transporter 2.493e-66 0.42
OPRM_RAT Oprm1 Mu-type opioid receptor 1.669e-62 0.42
SGMR1_MOUSE Sigmar1 Sigma non-opioid intracellular receptor 1 1.646e-53 0.40
CCR3_HUMAN CCR3 C-C chemokine receptor type 3 1.544e-49 0.44
GALR1_RAT Galr1 Galanin receptor type 1 6.384e-48 0.31
GALR2_RAT Galr2 Galanin receptor type 2 6.384e-48 0.31
ADRB3_RAT Adrb3 Beta-3 adrenergic receptor 1.184e-47 0.38
O19067_PIG N-methyl-D-aspartate receptor 1.472e-45 0.36
ADRB2_RAT Adrb2 Beta-2 adrenergic receptor 6.63e-42 0.38
DRD2_MOUSE Drd2 D(2) dopamine receptor 8.94e-40 0.39
UBC12_HUMAN UBE2M NEDD8-conjugating enzyme Ubc12 1.381e-38 0.31
TYRP1_MOUSE Tyrp1 5,6-dihydroxyindole-2-carboxylic acid oxidase 5.333e-38 0.32
ANM6_HUMAN PRMT6 Protein arginine N-methyltransferase 6 1.168e-36 0.49
AMPB_MOUSE Rnpep Aminopeptidase B 1.948e-36 0.29
AMPL_BOVIN LAP3 Cytosol aminopeptidase 1.948e-36 0.29
OPRD_RAT Oprd1 Delta-type opioid receptor 1.351e-35 0.42
CP24A_RAT Cyp24a1 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial 3.496e-35 0.33
OPRD_MOUSE Oprd1 Delta-type opioid receptor 5.131e-33 0.35
OPRM_CAVPO OPRM1 Mu-type opioid receptor 1.265e-31 0.42
NEP_RABIT MME Neprilysin 8.463e-31 0.33
CARM1_HUMAN CARM1 Histone-arginine methyltransferase CARM1 6.686e-28 0.49
MRGX1_RAT Mrgprx1 Mas-related G-protein coupled receptor member X1 2.54e-26 0.32
ACES_MOUSE Ache Acetylcholinesterase 4.391e-26 0.34
SCN2A_RAT Scn2a Sodium channel protein type 2 subunit alpha 9.497e-26 0.45
H9TVJ1_CHISP TyR1 2.901e-25 0.31
OPRK_RAT Oprk1 Kappa-type opioid receptor 3.413e-24 0.33
S6A12_MOUSE Slc6a12 Sodium- and chloride-dependent betaine transporter 5.921e-24 0.33
NK1R_RAT Tacr1 Substance-P receptor 2.933e-23 0.34
ACE_RAT Ace Angiotensin-converting enzyme 5.965e-23 0.33
SC6A4_RAT Slc6a4 Sodium-dependent serotonin transporter 1.019e-20 0.39
NMDE2_MOUSE Grin2b Glutamate receptor ionotropic, NMDA 2B 1.325e-20 0.29
ACE_HUMAN ACE Angiotensin-converting enzyme 6.31e-20 0.32
OPRK_CAVPO OPRK1 Kappa-type opioid receptor 9.628e-20 0.42
ACM2_HUMAN CHRM2 Muscarinic acetylcholine receptor M2 1.334e-19 0.35
LCAP_RAT Lnpep Leucyl-cystinyl aminopeptidase 3.488e-18 0.29
GLUT4_HUMAN SLC2A4 Solute carrier family 2, facilitated glucose transporter member 4 6.556e-18 0.28
NR1D2_HUMAN NR1D2 Nuclear receptor subfamily 1 group D member 2 6.556e-18 0.28
XIAP_HUMAN XIAP E3 ubiquitin-protein ligase XIAP 4.419e-17 0.33
SC6A2_HUMAN SLC6A2 Sodium-dependent noradrenaline transporter 5.171e-17 0.47
NK1R_MOUSE Tacr1 Substance-P receptor 1.11e-16 0.32
CAC1C_RAT Cacna1c Voltage-dependent L-type calcium channel subunit alpha-1C 5.551e-16 0.37
CCR5_HUMAN CCR5 C-C chemokine receptor type 5 5.551e-16 0.38
MGLL_HUMAN MGLL Monoglyceride lipase 5.551e-16 0.44
OPRD_HUMAN OPRD1 Delta-type opioid receptor 1.332e-15 0.35
MA2A1_HUMAN MAN2A1 Alpha-mannosidase 2 1.887e-15 0.29
Q63380_RAT NET Transporter 3.442e-15 0.39
CPNS1_PIG CAPNS1 Calpain small subunit 1 3.553e-15 0.29
MA1B1_HUMAN MAN1B1 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase 5.107e-15 0.29
SC6A4_HUMAN SLC6A4 Sodium-dependent serotonin transporter 5.44e-15 0.44
S6A11_MOUSE Slc6a11 Sodium- and chloride-dependent GABA transporter 3 9.215e-15 0.33
HRH1_CAVPO HRH1 Histamine H1 receptor 1.377e-14 0.41
ANM8_HUMAN PRMT8 Protein arginine N-methyltransferase 8 1.754e-14 0.43
VACHT_RAT Slc18a3 Vesicular acetylcholine transporter 1.998e-14 0.43
ACE_RABIT ACE Angiotensin-converting enzyme 3.32e-14 0.31
ACE2_RAT Ace2 Angiotensin-converting enzyme 2 4.43e-14 0.31
CCR5_MOUSE Ccr5 C-C chemokine receptor type 5 6.517e-14 0.35
AMP1_PLAFQ M1 family aminopeptidase 1.078e-13 0.45
SC6A3_HUMAN SLC6A3 Sodium-dependent dopamine transporter 1.097e-13 0.47
XPP1_HUMAN XPNPEP1 Xaa-Pro aminopeptidase 1 1.102e-13 0.30
NK1R_HUMAN TACR1 Substance-P receptor 1.155e-13 0.34
RENI_HUMAN REN Renin 2.048e-13 0.33
CHLE_HORSE BCHE Cholinesterase 2.468e-13 0.41
NEP_MOUSE Mme Neprilysin 3.922e-13 0.29
SGMR2_HUMAN TMEM97 Sigma intracellular receptor 2 6.682e-13 0.31
Q72874_9HIV1 pol Pol polyprotein 1.2e-12 0.33
CAN1_HUMAN CAPN1 Calpain-1 catalytic subunit 4.17e-12 0.31
Q9WTR4_RAT Slc6a2 Transporter 4.981e-12 0.38
AMPX_VIBPR Bacterial leucyl aminopeptidase 7.838e-12 0.29
CATD_BOVIN CTSD Cathepsin D 8.624e-12 0.30
BIRC8_HUMAN BIRC8 Baculoviral IAP repeat-containing protein 8 9.7e-12 0.29
MAOX_HUMAN ME1 NADP-dependent malic enzyme 9.7e-12 0.29
MRGX1_MOUSE Mrgprx1 Mas-related G-protein coupled receptor member X1 1.437e-11 0.28
SYYC_HUMAN YARS1 Tyrosine--tRNA ligase, cytoplasmic 3.704e-11 0.32
XPP2_RAT Xpnpep2 Xaa-Pro aminopeptidase 2 3.989e-11 0.30
ADRB3_MACMU ADRB3 Beta-3 adrenergic receptor 8.191e-11 0.29
CAN1_PIG CAPN1 Calpain-1 catalytic subunit 8.887e-11 0.30
NK1R_CAVPO TACR1 Substance-P receptor 9.089e-11 0.34
AMPN_MOUSE Anpep Aminopeptidase N 9.112e-11 0.29
DRD1_BOVIN DRD1 D(1A) dopamine receptor 1.059e-10 0.30
CATB_BOVIN CTSB Cathepsin B 2.076e-10 0.30
ACES_ELEEL ache Acetylcholinesterase 2.345e-10 0.41
NEP_RAT Mme Neprilysin 3.119e-10 0.31
NMUR2_HUMAN NMUR2 Neuromedin-U receptor 2 3.757e-10 0.32
SOAT1_CHLAE SOAT1 Sterol O-acyltransferase 1 5.388e-10 0.29
NEP_PIG MME Neprilysin 6.439e-10 0.29
CATL1_RAT Ctsl Cathepsin L1 6.857e-10 0.30
RYR2_HUMAN RYR2 Ryanodine receptor 2 1.102e-09 0.34
MRGX1_HUMAN MRGPRX1 Mas-related G-protein coupled receptor member X1 1.25e-09 0.32
XPP2_HUMAN XPNPEP2 Xaa-Pro aminopeptidase 2 1.516e-09 0.30
KCNQ2_HUMAN KCNQ2 Potassium voltage-gated channel subfamily KQT member 2 2.911e-09 0.30
AMD_HUMAN PAM Peptidyl-glycine alpha-amidating monooxygenase 3.152e-09 0.29
VACHT_TETCF Vesicular acetylcholine transporter 3.481e-09 0.36
ACHA9_RAT Chrna9 Neuronal acetylcholine receptor subunit alpha-9 5.048e-09 0.28
OPRM_HUMAN OPRM1 Mu-type opioid receptor 1.1e-08 0.35
VMAT2_HUMAN SLC18A2 Synaptic vesicular amine transporter 1.512e-08 0.32
S6A13_MOUSE Slc6a13 Sodium- and chloride-dependent GABA transporter 2 2.184e-08 0.31
O07911_STAAU agrC AgrC 3.985e-08 0.29
PANK3_HUMAN PANK3 Pantothenate kinase 3 4.063e-08 0.32
ACES_HUMAN ACHE Acetylcholinesterase 4.145e-08 0.34
VACHT_HUMAN SLC18A3 Vesicular acetylcholine transporter 6.807e-08 0.43
SOAT2_CHLAE SOAT2 Sterol O-acyltransferase 2 7.964e-08 0.29
BIRC2_HUMAN BIRC2 Baculoviral IAP repeat-containing protein 2 1.302e-07 0.29
OPRK_HUMAN OPRK1 Kappa-type opioid receptor 1.397e-07 0.42
ACE_MOUSE Ace Angiotensin-converting enzyme 1.612e-07 0.31
5HT2C_RAT Htr2c 5-hydroxytryptamine receptor 2C 1.676e-07 0.43
ACES_RAT Ache Acetylcholinesterase 1.814e-07 0.32
DRD2_RAT Drd2 D(2) dopamine receptor 2.097e-07 0.48
DRD4_HUMAN DRD4 D(4) dopamine receptor 2.343e-07 0.39
ACPS_BACSU acpS Holo-[acyl-carrier-protein] synthase 2.38e-07 0.30
AMPB_RAT Rnpep Aminopeptidase B 4.339e-07 0.29
PSA_HUMAN NPEPPS Puromycin-sensitive aminopeptidase 4.339e-07 0.29
CAN2_HUMAN CAPN2 Calpain-2 catalytic subunit 4.637e-07 0.31
ADRB2_BOVIN ADRB2 Beta-2 adrenergic receptor 6.008e-07 0.33
SC6A3_MACFA SLC6A3 Sodium-dependent dopamine transporter 6.013e-07 0.28
OGT1_HUMAN OGT UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 7.232e-07 0.33
ACM1_HUMAN CHRM1 Muscarinic acetylcholine receptor M1 8.156e-07 0.33
SCN4A_HUMAN SCN4A Sodium channel protein type 4 subunit alpha 8.853e-07 0.29
AMPN_HUMAN ANPEP Aminopeptidase N 1.047e-06 0.30
CP2J2_HUMAN CYP2J2 Cytochrome P450 2J2 1.542e-06 0.32
CPNS1_HUMAN CAPNS1 Calpain small subunit 1 2.558e-06 0.29
CATK_HUMAN CTSK Cathepsin K 5.164e-06 0.32
CHLE_HUMAN BCHE Cholinesterase 5.987e-06 0.34
HRH3_HUMAN HRH3 Histamine H3 receptor 7.086e-06 0.49
ACE2_HUMAN ACE2 Angiotensin-converting enzyme 2 8.884e-06 0.30
AMPN_PIG ANPEP Aminopeptidase N 9.04e-06 0.45
ADRB2_CAVPO Adrb2 Beta-2 adrenergic receptor 9.744e-06 0.34

Regorafenib

VGFR2_HUMAN KDR Vascular endothelial growth factor receptor 2 2.658e-93 1.00
BRAF_HUMAN BRAF Serine/threonine-protein kinase B-raf 6.425e-89 1.00
PGFRA_HUMAN PDGFRA Platelet-derived growth factor receptor alpha 1.269e-32 1.00
HYES_HUMAN EPHX2 Bifunctional epoxide hydrolase 2 1.11e-16 1.00
KIT_HUMAN KIT Mast/stem cell growth factor receptor Kit 3.775e-15 1.00
GLRA1_HUMAN GLRA1 Glycine receptor subunit alpha-1 6.82e-11 1.00
PGFRB_HUMAN PDGFRB Platelet-derived growth factor receptor beta 9.066e-11 1.00
RAF1_HUMAN RAF1 RAF proto-oncogene serine/threonine-protein kinase 4.9e-99 0.83
VGFR2_DANRE kdr Vascular endothelial growth factor receptor 2 5.026e-89 0.83
GRM4_RAT Grm4 Metabotropic glutamate receptor 4 3.271e-68 0.49
P2RY1_HUMAN P2RY1 P2Y purinoceptor 1 3.698e-58 0.43
ABL1_MOUSE Abl1 Tyrosine-protein kinase ABL1 1.451e-55 0.83
TMPS4_HUMAN TMPRSS4 Transmembrane protease serine 4 3.565e-48 0.32
PYGL_MOUSE Pygl Glycogen phosphorylase, liver form 4.082e-46 0.35
PYGL_RAT Pygl Glycogen phosphorylase, liver form 2.548e-42 0.35
VGFR1_HUMAN FLT1 Vascular endothelial growth factor receptor 1 3.254e-42 0.83
CDKL3_HUMAN CDKL3 Cyclin-dependent kinase-like 3 6.404e-38 0.83
BLM_HUMAN BLM Bloom syndrome protein 1.833e-37 0.44
S20A2_HUMAN SLC20A2 Sodium-dependent phosphate transporter 2 9.406e-37 0.29
GRM4_HUMAN GRM4 Metabotropic glutamate receptor 4 1.275e-34 0.49
PYGM_HUMAN PYGM Glycogen phosphorylase, muscle form 8.117e-31 0.38
ARAF_HUMAN ARAF Serine/threonine-protein kinase A-Raf 4.389e-30 0.83
MYO3B_HUMAN MYO3B Myosin-IIIb 8.61e-28 0.83
TIE2_HUMAN TEK Angiopoietin-1 receptor 1.251e-26 0.83
PAFA_HUMAN PLA2G7 Platelet-activating factor acetylhydrolase 3.153e-26 0.35
RPGF3_HUMAN RAPGEF3 Rap guanine nucleotide exchange factor 3 9.244e-25 0.33
MK03_HUMAN MAPK3 Mitogen-activated protein kinase 3 2.394e-24 0.83
CDK15_HUMAN CDK15 Cyclin-dependent kinase 15 2.408e-24 0.83
SCNAA_RAT Scn10a Sodium channel protein type 10 subunit alpha 4.188e-24 0.33
S20A1_HUMAN SLC20A1 Sodium-dependent phosphate transporter 1 1.158e-23 0.29
WRN_HUMAN WRN Werner syndrome ATP-dependent helicase 6.568e-22 0.36
EPHB_MYCTO Epoxide hydrolase B 3.159e-21 0.34
RPGF4_MOUSE Rapgef4 Rap guanine nucleotide exchange factor 4 3.368e-21 0.33
CDK14_HUMAN CDK14 Cyclin-dependent kinase 14 4.011e-21 0.83
SMN_HUMAN SMN1; SMN2 Survival motor neuron protein 1.389e-20 0.32
CDK17_HUMAN CDK17 Cyclin-dependent kinase 17 1.769e-20 0.83
PYGL_HUMAN PYGL Glycogen phosphorylase, liver form 6.271e-20 0.38
CDKL2_HUMAN CDKL2 Cyclin-dependent kinase-like 2 2.492e-19 0.83
CDPK1_PLAF7 CPK1 Calcium-dependent protein kinase 1 2.492e-19 0.83
MUSK_HUMAN MUSK Muscle, skeletal receptor tyrosine-protein kinase 2.492e-19 0.83
RIPK1_HUMAN RIPK1 Receptor-interacting serine/threonine-protein kinase 1 2.613e-19 0.43
MECP2_HUMAN MECP2 Methyl-CpG-binding protein 2 5.576e-19 0.30
STK36_HUMAN STK36 Serine/threonine-protein kinase 36 8.15e-19 0.83
NLK_HUMAN NLK Serine/threonine-protein kinase NLK 1.511e-18 0.83
MYLK2_HUMAN MYLK2 Myosin light chain kinase 2, skeletal/cardiac muscle 6.944e-18 0.83
EPHB2_HUMAN EPHB2 Ephrin type-B receptor 2 9.457e-18 0.83
SHH_MOUSE Shh Sonic hedgehog protein 1.475e-17 0.33
MK15_HUMAN MAPK15 Mitogen-activated protein kinase 15 1.836e-17 0.83
EPHA7_HUMAN EPHA7 Ephrin type-A receptor 7 4.585e-17 0.83
TNK1_HUMAN TNK1 Non-receptor tyrosine-protein kinase TNK1 4.585e-17 0.83
ABL2_HUMAN ABL2 Tyrosine-protein kinase ABL2 1.11e-16 0.83
EPHA5_HUMAN EPHA5 Ephrin type-A receptor 5 1.11e-16 0.83
GRM5_RAT Grm5 Metabotropic glutamate receptor 5 1.11e-16 0.42
SMCA2_HUMAN SMARCA2 Probable global transcription activator SNF2L2 1.11e-16 0.31
SRMS_HUMAN SRMS Tyrosine-protein kinase Srms 1.11e-16 0.83
MK13_HUMAN MAPK13 Mitogen-activated protein kinase 13 4.441e-16 0.83
EPHA8_HUMAN EPHA8 Ephrin type-A receptor 8 5.551e-16 0.83
KS6A6_HUMAN RPS6KA6 Ribosomal protein S6 kinase alpha-6 5.551e-16 0.83
TAOK2_HUMAN TAOK2 Serine/threonine-protein kinase TAO2 5.551e-16 0.83
MYLK3_HUMAN MYLK3 Myosin light chain kinase 3 1.11e-15 0.83
CDKL1_HUMAN CDKL1 Cyclin-dependent kinase-like 1 1.665e-15 0.34
ANDR_RAT Ar Androgen receptor 1.776e-15 0.43
RIPK2_HUMAN RIPK2 Receptor-interacting serine/threonine-protein kinase 2 1.887e-15 0.83
EPHA4_HUMAN EPHA4 Ephrin type-A receptor 4 2.22e-15 0.83
CTRO_HUMAN CIT Citron Rho-interacting kinase 4.33e-15 0.83
HIPK3_HUMAN HIPK3 Homeodomain-interacting protein kinase 3 4.33e-15 0.83
SRPK1_HUMAN SRPK1 SRSF protein kinase 1 7.327e-15 0.83
M4K1_HUMAN MAP4K1 Mitogen-activated protein kinase kinase kinase kinase 1 8.105e-15 0.83
BRAF_MOUSE Braf Serine/threonine-protein kinase B-raf 9.992e-15 0.83
EPHA1_HUMAN EPHA1 Ephrin type-A receptor 1 1.465e-14 0.83
EPHB1_HUMAN EPHB1 Ephrin type-B receptor 1 1.465e-14 0.83
EPHA6_HUMAN EPHA6 Ephrin type-A receptor 6 2.609e-14 0.83
HIPK4_HUMAN HIPK4 Homeodomain-interacting protein kinase 4 2.742e-14 0.83
MET_HUMAN MET Hepatocyte growth factor receptor 4.674e-14 0.40
BLK_HUMAN BLK Tyrosine-protein kinase Blk 5.24e-14 0.83
M3K6_HUMAN MAP3K6 Mitogen-activated protein kinase kinase kinase 6 7.505e-14 0.34
NTRK2_HUMAN NTRK2 BDNF/NT-3 growth factors receptor 1.211e-13 0.83
HIPK1_HUMAN HIPK1 Homeodomain-interacting protein kinase 1 1.267e-13 0.83
TIE1_HUMAN TIE1 Tyrosine-protein kinase receptor Tie-1 1.267e-13 0.83
STK33_HUMAN STK33 Serine/threonine-protein kinase 33 1.867e-13 0.83
FLT3_HUMAN FLT3 Receptor-type tyrosine-protein kinase FLT3 3.139e-13 0.83
SMCA4_HUMAN SMARCA4 Transcription activator BRG1 3.902e-13 0.31
ABL1_HUMAN ABL1 Tyrosine-protein kinase ABL1 5.486e-13 0.83
CSF1R_HUMAN CSF1R Macrophage colony-stimulating factor 1 receptor 7.909e-13 0.83
TRPV1_HUMAN TRPV1 Transient receptor potential cation channel subfamily V member 1 8.199e-13 0.47
IMDH_CRYPV Inosine-5'-monophosphate dehydrogenase 2.95e-12 0.38
VGFR2_MOUSE Kdr Vascular endothelial growth factor receptor 2 3.462e-12 0.83
MP2K5_HUMAN MAP2K5 Dual specificity mitogen-activated protein kinase kinase 5 3.805e-12 0.83
STK10_HUMAN STK10 Serine/threonine-protein kinase 10 7.731e-12 0.83
EPHA3_HUMAN EPHA3 Ephrin type-A receptor 3 1.083e-11 0.83
SOAT1_RAT Soat1 Sterol O-acyltransferase 1 1.389e-11 0.33
LYN_HUMAN LYN Tyrosine-protein kinase Lyn 1.479e-11 0.83
NTRK3_HUMAN NTRK3 NT-3 growth factor receptor 1.551e-11 0.83
KCNJ5_HUMAN KCNJ5 G protein-activated inward rectifier potassium channel 4 3.397e-11 0.38
MALT1_HUMAN MALT1 Mucosa-associated lymphoid tissue lymphoma translocation protein 1 3.581e-11 0.31
CDK3_HUMAN CDK3 Cyclin-dependent kinase 3 3.619e-11 0.83
FRK_HUMAN FRK Tyrosine-protein kinase FRK 6.458e-11 0.83
MAK_HUMAN MAK Serine/threonine-protein kinase MAK 8.636e-11 0.34
M3K19_HUMAN MAP3K19 Mitogen-activated protein kinase kinase kinase 19 8.762e-11 0.83
DDR2_HUMAN DDR2 Discoidin domain-containing receptor 2 8.826e-11 0.83
KCNJ6_HUMAN KCNJ6 G protein-activated inward rectifier potassium channel 2 9.056e-11 0.30
M3K20_HUMAN MAP3K20 Mitogen-activated protein kinase kinase kinase 20 1.1e-10 0.83
KCC2B_HUMAN CAMK2B Calcium/calmodulin-dependent protein kinase type II subunit beta 1.119e-10 0.83
VGFR3_HUMAN FLT4 Vascular endothelial growth factor receptor 3 1.253e-10 0.83
LIMK1_HUMAN LIMK1 LIM domain kinase 1 1.929e-10 0.83
KCNJ3_HUMAN KCNJ3 G protein-activated inward rectifier potassium channel 1 2.073e-10 0.38
NTRK1_HUMAN NTRK1 High affinity nerve growth factor receptor 3.616e-10 0.83
KAPCB_HUMAN PRKACB cAMP-dependent protein kinase catalytic subunit beta 4.066e-10 0.34
ST38L_HUMAN STK38L Serine/threonine-protein kinase 38-like 4.066e-10 0.34
RET_HUMAN RET Proto-oncogene tyrosine-protein kinase receptor Ret 4.278e-10 0.83
FYN_HUMAN FYN Tyrosine-protein kinase Fyn 7.038e-10 0.83
MKNK1_HUMAN MKNK1 MAP kinase-interacting serine/threonine-protein kinase 1 1.326e-09 0.83
NEK9_HUMAN NEK9 Serine/threonine-protein kinase Nek9 1.513e-09 0.34
TGFR2_HUMAN TGFBR2 TGF-beta receptor type-2 1.692e-09 0.83
EPHB6_HUMAN EPHB6 Ephrin type-B receptor 6 2.037e-09 0.83
FGR_HUMAN FGR Tyrosine-protein kinase Fgr 2.048e-09 0.83
LIMK1_RAT Limk1 LIM domain kinase 1 2.136e-09 0.31
ROS1_HUMAN ROS1 Proto-oncogene tyrosine-protein kinase ROS 2.277e-09 0.60
P2Y14_HUMAN P2RY14 P2Y purinoceptor 14 2.282e-09 0.34
CSK_HUMAN CSK Tyrosine-protein kinase CSK 2.469e-09 0.83
TAAR1_RAT Taar1 Trace amine-associated receptor 1 3.816e-09 0.34
KTHY_MYCTU tmk Thymidylate kinase 3.955e-09 0.33
CDKL5_HUMAN CDKL5 Cyclin-dependent kinase-like 5 4.69e-09 0.34
KCC4_HUMAN CAMK4 Calcium/calmodulin-dependent protein kinase type IV 4.69e-09 0.34
MYO3A_HUMAN MYO3A Myosin-IIIa 4.69e-09 0.34
STK39_HUMAN STK39 STE20/SPS1-related proline-alanine-rich protein kinase 4.69e-09 0.34
PLK4_HUMAN PLK4 Serine/threonine-protein kinase PLK4 5.023e-09 0.83
SLK_HUMAN SLK STE20-like serine/threonine-protein kinase 8.773e-09 0.83
MK10_HUMAN MAPK10 Mitogen-activated protein kinase 10 9.016e-09 0.34
EFC4B_HUMAN CRACR2A EF-hand calcium-binding domain-containing protein 4B 1.173e-08 0.32
CD11A_HUMAN CDK11A Cyclin-dependent kinase 11A 1.258e-08 0.34
CDK13_HUMAN CDK13 Cyclin-dependent kinase 13 1.258e-08 0.34
IRAK1_HUMAN IRAK1 Interleukin-1 receptor-associated kinase 1 1.271e-08 0.83
GRIK1_HUMAN GRIK1 Glutamate receptor ionotropic, kainate 1 2.184e-08 0.32
HIPK2_HUMAN HIPK2 Homeodomain-interacting protein kinase 2 2.398e-08 0.83
AURKC_HUMAN AURKC Aurora kinase C 2.661e-08 0.83
CSF1R_MOUSE Csf1r Macrophage colony-stimulating factor 1 receptor 2.806e-08 0.35
UFO_HUMAN AXL Tyrosine-protein kinase receptor UFO 2.931e-08 0.83
NEK5_HUMAN NEK5 Serine/threonine-protein kinase Nek5 3e-08 0.34
LUCI_RENRE Coelenterazine h 2-monooxygenase 3.301e-08 0.29
MINK1_HUMAN MINK1 Misshapen-like kinase 1 3.38e-08 0.83
MK09_HUMAN MAPK9 Mitogen-activated protein kinase 9 3.453e-08 0.83
GRM7_RAT Grm7 Metabotropic glutamate receptor 7 3.735e-08 0.31
TAOK1_HUMAN TAOK1 Serine/threonine-protein kinase TAO1 4.063e-08 0.83
CDK19_HUMAN CDK19 Cyclin-dependent kinase 19 4.545e-08 0.83
M3K1_HUMAN MAP3K1 Mitogen-activated protein kinase kinase kinase 1 6.502e-08 0.34
TYK2_HUMAN TYK2 Non-receptor tyrosine-protein kinase TYK2 6.81e-08 0.60
M4K5_HUMAN MAP4K5 Mitogen-activated protein kinase kinase kinase kinase 5 7.84e-08 0.83
CD11B_HUMAN CDK11B Cyclin-dependent kinase 11B 1.3e-07 0.34
LATS1_HUMAN LATS1 Serine/threonine-protein kinase LATS1 1.3e-07 0.34
SGK3_HUMAN SGK3 Serine/threonine-protein kinase Sgk3 1.3e-07 0.34
MKNK2_HUMAN MKNK2 MAP kinase-interacting serine/threonine-protein kinase 2 1.922e-07 0.83
STK3_HUMAN STK3 Serine/threonine-protein kinase 3 2.17e-07 0.34
TAOK3_HUMAN TAOK3 Serine/threonine-protein kinase TAO3 2.419e-07 0.83
AVR2B_HUMAN ACVR2B Activin receptor type-2B 2.432e-07 0.34
CDK18_HUMAN CDK18 Cyclin-dependent kinase 18 2.432e-07 0.34
STK24_HUMAN STK24 Serine/threonine-protein kinase 24 2.432e-07 0.34
NEK4_HUMAN NEK4 Serine/threonine-protein kinase Nek4 2.702e-07 0.34
Q6FTL6_CANGA NCE103 Carbonic anhydrase 3.021e-07 0.38
NEK6_HUMAN NEK6 Serine/threonine-protein kinase Nek6 4.293e-07 0.34
RIPK4_HUMAN RIPK4 Receptor-interacting serine/threonine-protein kinase 4 4.293e-07 0.34
EPHA2_HUMAN EPHA2 Ephrin type-A receptor 2 5.189e-07 0.83
PPIA_RAT Ppia Peptidyl-prolyl cis-trans isomerase A 5.365e-07 0.30
LCK_HUMAN LCK Tyrosine-protein kinase Lck 6.445e-07 0.83
CILK1_HUMAN CILK1 Serine/threonine-protein kinase ICK 7.213e-07 0.34
INSRR_HUMAN INSRR Insulin receptor-related protein 7.213e-07 0.34
M4K4_HUMAN MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4 7.567e-07 0.83
ACVR1_HUMAN ACVR1 Activin receptor type-1 8.081e-07 0.30
KS6A4_HUMAN RPS6KA4 Ribosomal protein S6 kinase alpha-4 9.331e-07 0.34
TAAR1_MOUSE Taar1 Trace amine-associated receptor 1 9.756e-07 0.34
DUSTY_HUMAN DSTYK Dual serine/threonine and tyrosine protein kinase 1.161e-06 0.34
LATS2_HUMAN LATS2 Serine/threonine-protein kinase LATS2 1.161e-06 0.34
TESK1_HUMAN TESK1 Dual specificity testis-specific protein kinase 1 1.161e-06 0.34
MK12_HUMAN MAPK12 Mitogen-activated protein kinase 12 1.233e-06 0.83
PDGFB_HUMAN PDGFB Platelet-derived growth factor subunit B 1.295e-06 0.35
MATK_HUMAN MATK Megakaryocyte-associated tyrosine-protein kinase 1.623e-06 0.34
M3K13_HUMAN MAP3K13 Mitogen-activated protein kinase kinase kinase 13 1.801e-06 0.34
KCC1A_HUMAN CAMK1 Calcium/calmodulin-dependent protein kinase type 1 1.883e-06 0.34
BACE2_HUMAN BACE2 Beta-secretase 2 1.976e-06 0.32
DDR1_HUMAN DDR1 Epithelial discoidin domain-containing receptor 1 2.1e-06 0.83
LOX15_HUMAN ALOX15 Arachidonate 15-lipoxygenase 2.538e-06 0.34
FGFR1_HUMAN FGFR1 Fibroblast growth factor receptor 1 2.606e-06 0.83
ANKK1_HUMAN ANKK1 Ankyrin repeat and protein kinase domain-containing protein 1 2.704e-06 0.34
STK35_HUMAN STK35 Serine/threonine-protein kinase 35 2.704e-06 0.34
KC1A_HUMAN CSNK1A1 Casein kinase I isoform alpha 2.976e-06 0.83
MK14_HUMAN MAPK14 Mitogen-activated protein kinase 14 3.125e-06 0.83
TTK_HUMAN TTK Dual specificity protein kinase TTK 3.333e-06 0.83
ATF1_HUMAN ATF1 Cyclic AMP-dependent transcription factor ATF-1 3.91e-06 0.29
STK25_HUMAN STK25 Serine/threonine-protein kinase 25 3.942e-06 0.34
PLK3_HUMAN PLK3 Serine/threonine-protein kinase PLK3 4.837e-06 0.34
DYRK3_HUMAN DYRK3 Dual specificity tyrosine-phosphorylation-regulated kinase 3 5.003e-06 0.83
KKCC1_HUMAN CAMKK1 Calcium/calmodulin-dependent protein kinase kinase 1 5.601e-06 0.34
RIOK2_HUMAN RIOK2 Serine/threonine-protein kinase RIO2 5.601e-06 0.34
ULK3_HUMAN ULK3 Serine/threonine-protein kinase ULK3 5.601e-06 0.34
MK11_HUMAN MAPK11 Mitogen-activated protein kinase 11 8.612e-06 0.83
TNIK_HUMAN TNIK TRAF2 and NCK-interacting protein kinase 8.612e-06 0.83

Vismodegib

SHH_MOUSE Shh Sonic hedgehog protein 6.101e-83 1.00
SMO_HUMAN SMO Smoothened homolog 8.721e-27 1.00
SMO_MOUSE Smo Smoothened homolog 2.039e-22 1.00
SHH_HUMAN SHH Sonic hedgehog protein 6.843e-21 1.00
GRM4_HUMAN GRM4 Metabotropic glutamate receptor 4 1.167e-125 0.47
GRM4_RAT Grm4 Metabotropic glutamate receptor 4 6.423e-114 0.46
NTRK1_HUMAN NTRK1 High affinity nerve growth factor receptor 1.611e-76 0.42
KCNK9_HUMAN KCNK9 Potassium channel subfamily K member 9 1.483e-66 0.40
Q8T8E9_9TRYP galE UDP-galactose 4-epimerase 2.555e-53 0.34
A6QR73_RAT Gpr39 G protein-coupled receptor 39 4.234e-51 0.35
PFKA_TRYBB pfk ATP-dependent 6-phosphofructokinase 1.232e-44 0.32
PFKA_TRYCC pfk ATP-dependent 6-phosphofructokinase 1.354e-43 0.32
C3SLB7_ECOLX glmU Bifunctional protein GlmU 3.294e-37 0.34
NADE_BACAN nadE NH(3)-dependent NAD(+) synthetase 3.56e-37 0.29
PRIO_SHEEP PRNP Major prion protein 4.845e-37 0.33
NMDZ1_MOUSE Grin1 Glutamate receptor ionotropic, NMDA 1 7.142e-37 0.29
IL1R1_HUMAN IL1R1 Interleukin-1 receptor type 1 1.195e-36 0.29
CYAA_BACAN cya Calmodulin-sensitive adenylate cyclase 4.698e-36 0.35
BAP1_HUMAN BAP1 Ubiquitin carboxyl-terminal hydrolase BAP1 1.097e-35 0.28
NR2E3_HUMAN NR2E3 Photoreceptor-specific nuclear receptor 1.913e-33 0.39
PLCB_HUMAN AGPAT2 1-acyl-sn-glycerol-3-phosphate acyltransferase beta 1.964e-33 0.34
COX2_SHEEP MT-CO2 Cytochrome c oxidase subunit 2 2.304e-32 0.31
G2YM83_BOTF4 Cytochrome b-c1 complex subunit Rieske, mitochondrial 6.778e-32 0.31
GRM1_HUMAN GRM1 Metabotropic glutamate receptor 1 2.485e-29 0.37
APOB_HUMAN APOB Apolipoprotein B-100 3.739e-29 0.32
UT2_RAT Slc14a2 Urea transporter 2 4.508e-29 0.29
GSK3B_MOUSE Gsk3b Glycogen synthase kinase-3 beta 1.824e-28 0.29
V2R_HUMAN AVPR2 Vasopressin V2 receptor 7.764e-28 0.36
NRAM2_HUMAN SLC11A2 Natural resistance-associated macrophage protein 2 1.719e-27 0.32
RXFP1_HUMAN RXFP1 Relaxin receptor 1 2.034e-27 0.38
SUMO1_HUMAN SUMO1 Small ubiquitin-related modifier 1 2.164e-27 0.34
IMDH_CRYPV Inosine-5'-monophosphate dehydrogenase 6.118e-26 0.37
FADS1_HUMAN FADS1 Acyl-CoA (8-3)-desaturase 2.354e-25 0.34
BXE_CLOBO botE Botulinum neurotoxin type E 1.494e-23 0.31
TMPS4_HUMAN TMPRSS4 Transmembrane protease serine 4 4.185e-23 0.28
CCR9_HUMAN CCR9 C-C chemokine receptor type 9 7.769e-23 0.36
UT1_RAT Slc14a1 Urea transporter 1 2.166e-20 0.29
GPR39_MOUSE Gpr39 G-protein coupled receptor 39 2.606e-20 0.37
RAC1_HUMAN RAC1 Ras-related C3 botulinum toxin substrate 1 4.972e-20 0.32
TRPV4_RAT Trpv4 Transient receptor potential cation channel subfamily V member 4 9.433e-20 0.39
ATR_HUMAN ATR Serine/threonine-protein kinase ATR 4.891e-19 0.38
EPHB_MYCTO Epoxide hydrolase B 8.596e-19 0.30
PARG_HUMAN PARG Poly(ADP-ribose) glycohydrolase 9.803e-19 0.30
GPR39_HUMAN GPR39 G-protein coupled receptor 39 1.11e-16 0.37
Q9SPL6_CICIN PPX1 Protoporphyrinogen oxidase 1.11e-16 0.32
Q9XQA6_POAAN psbA Photosystem II protein D1 1.11e-16 0.32
UBP47_HUMAN USP47 Ubiquitin carboxyl-terminal hydrolase 47 1.11e-16 0.33
FABH_STRP3 fabH 3-oxoacyl-[acyl-carrier-protein] synthase 3 2.22e-16 0.31
KDM3A_HUMAN KDM3A Lysine-specific demethylase 3A 2.22e-16 0.32
SMN_HUMAN SMN1; SMN2 Survival motor neuron protein 2.22e-16 0.31
Q9I8A2_CHICK VATB Vacuolar proton pump subunit B 6.661e-16 0.30
KCNK3_HUMAN KCNK3 Potassium channel subfamily K member 3 1.332e-15 0.40
Q932Y6_PSEAI bla(tem-2) Beta-lactamase 1.443e-15 0.40
TYK2_HUMAN TYK2 Non-receptor tyrosine-protein kinase TYK2 1.443e-15 0.41
RORG_HUMAN RORC Nuclear receptor ROR-gamma 6.217e-15 0.39
S12A2_HUMAN SLC12A2 Solute carrier family 12 member 2 2.454e-14 0.36
V1AR_HUMAN AVPR1A Vasopressin V1a receptor 3.431e-14 0.36
SORT_HUMAN SORT1 Sortilin 6.772e-14 0.31
MTP_HUMAN MTTP Microsomal triglyceride transfer protein large subunit 1.643e-13 0.32
PTN13_HUMAN PTPN13 Tyrosine-protein phosphatase non-receptor type 13 6.405e-13 0.34
PDE4C_HUMAN PDE4C cAMP-specific 3',5'-cyclic phosphodiesterase 4C 1.874e-12 0.37
CSF1R_HUMAN CSF1R Macrophage colony-stimulating factor 1 receptor 2.395e-12 0.40
SCNAA_RAT Scn10a Sodium channel protein type 10 subunit alpha 3.121e-12 0.31
PTGES_HUMAN PTGES Prostaglandin E synthase 1.641e-11 0.40
HPPD_ARATH HPD 4-hydroxyphenylpyruvate dioxygenase 3.455e-11 0.38
PGH2_SHEEP PTGS2 Prostaglandin G/H synthase 2 3.844e-11 0.42
PTPRC_HUMAN PTPRC Receptor-type tyrosine-protein phosphatase C 4.143e-11 0.35
RORG_MOUSE Rorc Nuclear receptor ROR-gamma 7.728e-11 0.32
S12A5_HUMAN SLC12A5 Solute carrier family 12 member 5 1.057e-10 0.36
Q9FBC5_STREE fabK Enoyl-ACP reductase II 1.347e-10 0.37
KDM4D_HUMAN KDM4D Lysine-specific demethylase 4D 1.494e-10 0.32
TRPV4_MOUSE Trpv4 Transient receptor potential cation channel subfamily V member 4 2.015e-10 0.30
5HT3A_CAVPO HTR3A 5-hydroxytryptamine receptor 3A 2.325e-10 0.30
PSBA_MARPO psbA Photosystem II protein D1 4.715e-10 0.32
V2R_RAT Avpr2 Vasopressin V2 receptor 4.85e-10 0.32
BRAF_HUMAN BRAF Serine/threonine-protein kinase B-raf 8.032e-10 0.41
PPBI_BOVIN ALPI Intestinal-type alkaline phosphatase 9.829e-10 0.39
PGH2_HUMAN PTGS2 Prostaglandin G/H synthase 2 9.869e-10 0.44
STIM1_RAT Stim1 Stromal interaction molecule 1 9.897e-10 0.29
SMCA2_HUMAN SMARCA2 Probable global transcription activator SNF2L2 1.292e-09 0.32
V1AR_RAT Avpr1a Vasopressin V1a receptor 1.388e-09 0.32
RIPK2_HUMAN RIPK2 Receptor-interacting serine/threonine-protein kinase 2 1.398e-09 0.29
TLR9_HUMAN TLR9 Toll-like receptor 9 1.414e-09 0.40
CAH4_HUMAN CA4 Carbonic anhydrase 4 1.447e-09 0.35
VGFR2_HUMAN KDR Vascular endothelial growth factor receptor 2 1.963e-09 0.40
GRM7_RAT Grm7 Metabotropic glutamate receptor 7 2.375e-09 0.35
VGFR1_HUMAN FLT1 Vascular endothelial growth factor receptor 1 2.377e-09 0.35
PEBB_HUMAN CBFB Core-binding factor subunit beta 2.539e-09 0.39
PPIA_RAT Ppia Peptidyl-prolyl cis-trans isomerase A 2.684e-09 0.41
AK1A1_RAT Akr1a1 Aldo-keto reductase family 1 member A1 5.897e-09 0.30
SENP7_HUMAN SENP7 Sentrin-specific protease 7 6.575e-09 0.38
UREA_CANEN Urease 6.899e-09 0.35
CH10_HUMAN HSPE1 10 kDa heat shock protein, mitochondrial 7.417e-09 0.29
CH60_HUMAN HSPD1 60 kDa heat shock protein, mitochondrial 7.417e-09 0.29
TRPV1_RAT Trpv1 Transient receptor potential cation channel subfamily V member 1 9.497e-09 0.40
MURB_ECOLI murB UDP-N-acetylenolpyruvoylglucosamine reductase 1.139e-08 0.31
TF7L2_HUMAN TCF7L2 Transcription factor 7-like 2 1.252e-08 0.36
TRPV4_HUMAN TRPV4 Transient receptor potential cation channel subfamily V member 4 1.639e-08 0.39
BKRB1_HUMAN BDKRB1 B1 bradykinin receptor 2.714e-08 0.38
SC6A9_HUMAN SLC6A9 Sodium- and chloride-dependent glycine transporter 1 2.996e-08 0.36
CAH7_HUMAN CA7 Carbonic anhydrase 7 3.076e-08 0.35
STRP_STRP1 ska Streptokinase A 3.473e-08 0.41
RORB_HUMAN RORB Nuclear receptor ROR-beta 4.643e-08 0.35
UBP7_HUMAN USP7 Ubiquitin carboxyl-terminal hydrolase 7 4.898e-08 0.33
CTNB1_HUMAN CTNNB1 Catenin beta-1 5.846e-08 0.36
PD2R_MOUSE Ptgdr Prostaglandin D2 receptor 6.06e-08 0.31
INSR_MOUSE Insr Insulin receptor 8.176e-08 0.29
NMDE2_HUMAN GRIN2B Glutamate receptor ionotropic, NMDA 2B 1.027e-07 0.31
PLCG2_HUMAN PLCG2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 1.031e-07 0.29
NMDZ1_HUMAN GRIN1 Glutamate receptor ionotropic, NMDA 1 1.072e-07 0.31
SMCA4_HUMAN SMARCA4 Transcription activator BRG1 1.578e-07 0.32
PYRD_HUMAN DHODH Dihydroorotate dehydrogenase (quinone), mitochondrial 1.641e-07 0.37
EST1_HUMAN CES1 Liver carboxylesterase 1 1.656e-07 0.48
NLRP3_HUMAN NLRP3 NACHT, LRR and PYD domains-containing protein 3 1.734e-07 0.32
KLF5_HUMAN KLF5 Krueppel-like factor 5 1.783e-07 0.33
PDE4B_HUMAN PDE4B cAMP-specific 3',5'-cyclic phosphodiesterase 4B 2.217e-07 0.37
CPT1B_HUMAN CPT1B Carnitine O-palmitoyltransferase 1, muscle isoform 2.223e-07 0.37
METC_ECOLI metC Cystathionine beta-lyase MetC 2.362e-07 0.29
LOX15_HUMAN ALOX15 Arachidonate 15-lipoxygenase 2.64e-07 0.34
GSTO1_HUMAN GSTO1 Glutathione S-transferase omega-1 3.513e-07 0.29
PYGL_HUMAN PYGL Glycogen phosphorylase, liver form 4.27e-07 0.33
LUCI_PHOPY Luciferin 4-monooxygenase 7.247e-07 0.36
AOFB_RAT Maob Amine oxidase [flavin-containing] B 8.011e-07 0.34
RORA_HUMAN RORA Nuclear receptor ROR-alpha 8.182e-07 0.35
RECA_MYCTU recA Protein RecA 9.707e-07 0.40
ACOD1_RAT Scd1 Acyl-CoA desaturase 1 9.951e-07 0.37
Q8MWR1_SPOFR USP Ultraspiracle protein 1.574e-06 0.33
Q8MWR2_SPOFR EcR Ecdysteroid receptor 1.574e-06 0.33
ACKR3_HUMAN ACKR3 Atypical chemokine receptor 3 1.766e-06 0.32
KDM4C_HUMAN KDM4C Lysine-specific demethylase 4C 1.923e-06 0.38
GPR55_HUMAN GPR55 G-protein coupled receptor 55 2.019e-06 0.40
NR1H4_HUMAN NR1H4 Bile acid receptor 2.398e-06 0.35
CP2C9_HUMAN CYP2C9 Cytochrome P450 2C9 2.548e-06 0.38
5NTD_RAT Nt5e 5'-nucleotidase 2.856e-06 0.30
CRCM1_RAT Orai1 Calcium release-activated calcium channel protein 1 2.862e-06 0.29
SKN1_CAEEL skn-1 Protein skinhead-1 2.892e-06 0.38
DNAB_MYCTU dnaB Replicative DNA helicase 2.896e-06 0.40
RL19A_YEAST RPL19A 60S ribosomal protein L19-A 2.955e-06 0.32
Q54A96_PLAFA dhod Dihydroorotate dehydrogenase 3.049e-06 0.40
CAH1_HUMAN CA1 Carbonic anhydrase 1 3.354e-06 0.34
Q8IL32_PLAF7 Heat shock protein 90, putative 3.369e-06 0.34
CAH2_HUMAN CA2 Carbonic anhydrase 2 3.617e-06 0.35
GASR_RAT Cckbr Gastrin/cholecystokinin type B receptor 4.161e-06 0.30
C4YTQ8_CANAW ATP-dependent molecular chaperone HSP82 4.431e-06 0.39
GRM8_RAT Grm8 Metabotropic glutamate receptor 8 5.125e-06 0.35
CCNE2_HUMAN CCNE2 G1/S-specific cyclin-E2 5.191e-06 0.32
NPY2R_HUMAN NPY2R Neuropeptide Y receptor type 2 6.146e-06 0.35
KLK7_HUMAN KLK7 Kallikrein-7 7.668e-06 0.31
Q03732_HBV HBcAg Capsid protein 8.822e-06 0.30
O61059_LEIME LmGT2 Glucose transporter 8.847e-06 0.33
BLM_HUMAN BLM Bloom syndrome protein 9.055e-06 0.32
PDE4A_HUMAN PDE4A cAMP-specific 3',5'-cyclic phosphodiesterase 4A 9.183e-06 0.37
CATD_HUMAN CTSD Cathepsin D 9.747e-06 0.33

Tauroursodeoxycholic_acid

GPBAR_HUMAN GPBAR1 G-protein coupled bile acid receptor 1 3.43e-74 1.00
NTCP2_HUMAN SLC10A2 Ileal sodium/bile acid cotransporter 2.812e-51 1.00
NR1H4_HUMAN NR1H4 Bile acid receptor 2.905e-32 1.00
PA21B_HUMAN PLA2G1B Phospholipase A2 0.001746 1.00
NTCP_HUMAN SLC10A1 Sodium/bile acid cotransporter 1.005e-109 0.81
EPHA2_MOUSE Epha2 Ephrin type-A receptor 2 2.876e-94 0.51
SIA4B_RAT St3gal2 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 4.797e-79 0.42
CAH4_BOVIN CA4 Carbonic anhydrase 4 4.438e-74 0.70
NTCP_RAT Slc10a1 Sodium/bile acid cotransporter 6.657e-72 0.81
MRP4_HUMAN ABCC4 Multidrug resistance-associated protein 4 1.31e-49 0.62
NPCL1_HUMAN NPC1L1 NPC1-like intracellular cholesterol transporter 1 1.805e-46 0.41
DHC24_HUMAN DHCR24 Delta(24)-sterol reductase 2.521e-45 0.41
CDC45_HUMAN CDC45 Cell division control protein 45 homolog 5.748e-39 0.31
SIA4A_HUMAN ST3GAL1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 1.65e-37 0.40
3BHS_MYCTU 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase 2.528e-37 0.32
AT12A_HUMAN ATP12A Potassium-transporting ATPase alpha chain 2 2.663e-36 0.30
NPC1_HUMAN NPC1 NPC intracellular cholesterol transporter 1 2.28e-32 0.35
G6PD_HUMAN G6PD Glucose-6-phosphate 1-dehydrogenase 1.8e-30 0.36
ABCBB_HUMAN ABCB11 Bile salt export pump 3.439e-29 0.74
CP125_MYCTU cyp125 Steroid C26-monooxygenase 5.643e-28 0.35
CAH2_HUMAN CA2 Carbonic anhydrase 2 1.043e-27 0.70
CAH1_HUMAN CA1 Carbonic anhydrase 1 2.528e-27 0.70
CRYAB_HUMAN CRYAB Alpha-crystallin B chain 5.245e-27 0.33
DHCR7_RAT Dhcr7 7-dehydrocholesterol reductase 1.238e-26 0.34
BXA1_CLOBO botA Botulinum neurotoxin type A 1.86e-25 0.35
CD4_HUMAN CD4 T-cell surface glycoprotein CD4 7.143e-25 0.31
Q9GRG7_9TRYP g6pd Glucose-6-phosphate 1-dehydrogenase 9.719e-24 0.29
S5A1_HUMAN SRD5A1 3-oxo-5-alpha-steroid 4-dehydrogenase 1 7.042e-23 0.34
SMT1_ARATH SMT1 Cycloartenol-C-24-methyltransferase 1.354e-22 0.36
S5A2_HUMAN SRD5A2 3-oxo-5-alpha-steroid 4-dehydrogenase 2 1.289e-20 0.34
CBG_HUMAN SERPINA6 Corticosteroid-binding globulin 8.282e-19 0.32
MPIP1_HUMAN CDC25A M-phase inducer phosphatase 1 1.059e-18 0.35
NR1I3_MOUSE Nr1i3 Nuclear receptor subfamily 1 group I member 3 2.139e-18 0.29
ENPP2_HUMAN ENPP2 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 1.11e-16 0.64
REST_BORBU resT Telomere resolvase ResT 2.22e-16 0.41
SHBG_HUMAN SHBG Sex hormone-binding globulin 1.561e-13 0.37
VDR_HUMAN VDR Vitamin D3 receptor 6.573e-13 0.53
AT1A1_CANLF ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 7.274e-13 0.29
EPHA7_HUMAN EPHA7 Ephrin type-A receptor 7 8.712e-12 0.44
ANDR_HUMAN AR Androgen receptor 1.371e-11 0.43
EPHA5_HUMAN EPHA5 Ephrin type-A receptor 5 1.567e-11 0.44
RORA_HUMAN RORA Nuclear receptor ROR-alpha 2.531e-11 0.38
EPHA8_HUMAN EPHA8 Ephrin type-A receptor 8 4.615e-11 0.44
EPHB3_HUMAN EPHB3 Ephrin type-B receptor 3 4.615e-11 0.44
NR1H3_HUMAN NR1H3 Oxysterols receptor LXR-alpha 9.725e-11 0.43
B4FS76_MAIZE 100281352 Delta(14)-sterol reductase 1.105e-10 0.29
Q2TU57_MAIZE Sterol-8,7-isomerase 1.105e-10 0.29
EPHA4_HUMAN EPHA4 Ephrin type-A receptor 4 1.219e-10 0.44
DPOLB_RAT Polb DNA polymerase beta 1.258e-10 0.53
GABR1_RAT Gabbr1 Gamma-aminobutyric acid type B receptor subunit 1 3.562e-10 0.33
FGF1_HUMAN FGF1 Fibroblast growth factor 1 4.13e-10 0.34
EPHA1_HUMAN EPHA1 Ephrin type-A receptor 1 4.427e-10 0.44
EPHB1_HUMAN EPHB1 Ephrin type-B receptor 1 4.427e-10 0.44
EPHA6_HUMAN EPHA6 Ephrin type-A receptor 6 6.548e-10 0.44
EPHB2_HUMAN EPHB2 Ephrin type-B receptor 2 9.522e-10 0.44
EPHB6_HUMAN EPHB6 Ephrin type-B receptor 6 4.985e-09 0.44
GBRD_HUMAN GABRD Gamma-aminobutyric acid receptor subunit delta 7.167e-09 0.33
GCR_HUMAN NR3C1 Glucocorticoid receptor 9.77e-09 0.71
ECR_DROME EcR Ecdysone receptor 2.058e-08 0.29
DPOLA_HUMAN POLA1 DNA polymerase alpha catalytic subunit 2.829e-08 0.35
EPHA3_HUMAN EPHA3 Ephrin type-A receptor 3 3.999e-08 0.44
EPHA2_HUMAN EPHA2 Ephrin type-A receptor 2 1.688e-07 0.48
DHB3_RAT Hsd17b3 Testosterone 17-beta-dehydrogenase 3 1.721e-07 0.29
SRBP2_HUMAN SREBF2 Sterol regulatory element-binding protein 2 3.409e-07 0.33
Q8IEK1_PLAF7 M1-family alanyl aminopeptidase 3.737e-07 0.70
SIAT1_HUMAN ST6GAL1 Beta-galactoside alpha-2,6-sialyltransferase 1 9.875e-07 0.33
CISD1_HUMAN CISD1 CDGSH iron-sulfur domain-containing protein 1 1.49e-06 0.70
MCR_HUMAN NR3C2 Mineralocorticoid receptor 2.484e-06 0.43

Boceprevir

A3EZI9_9HEPC NS3 Genome polyprotein 1.707e-72 1.00
A0A0K1CY61_9HEPC Nonstructural protein NS3-4A 2.442e-15 1.00
CATF_HUMAN CTSF Cathepsin F 4.785e-14 1.00
CATL2_HUMAN CTSV Cathepsin L2 1.942e-07 1.00
CATB_HUMAN CTSB Cathepsin B 3.903e-06 1.00
THRB_HUMAN F2 Prothrombin 1.878e-05 1.00
CMA1_HUMAN CMA1 Chymase 0.00206 1.00
CATL1_HUMAN CTSL Cathepsin L1 0.009643 1.00
CATK_HUMAN CTSK Cathepsin K 0.0247 1.00
CATS_HUMAN CTSS Cathepsin S 0.1071 1.00
Q91RS4_9HEPC NS3 protease 1.045e-29 0.73
CASPA_HUMAN CASP10 Caspase-10 9.402e-20 0.31
RIR1_HHV11 RIR1 Ribonucleoside-diphosphate reductase large subunit 1.158e-18 0.31
C1KIQ2_9HEPC NS3 protease 4.016e-17 0.33
Q4U254_9ENTO protease Protease 5.551e-16 0.39
CASP4_HUMAN CASP4 Caspase-4 5.904e-10 0.31
CASP9_HUMAN CASP9 Caspase-9 4.7e-09 0.31
DEFM_HUMAN PDF Peptide deformylase, mitochondrial 1.045e-07 0.30
DEF_STRPN def Peptide deformylase 1.38e-07 0.33
CELA1_HUMAN CELA1 Chymotrypsin-like elastase family member 1 2.51e-07 0.33
DEF_STAAU def Peptide deformylase 4.643e-07 0.33
D2K2A8_9HEPC NS4A Non-structural protein 4A 6.737e-07 0.31
CASP5_HUMAN CASP5 Caspase-5 2.343e-06 0.31

Ruxolitinib

JAK3_HUMAN JAK3 Tyrosine-protein kinase JAK3 6.19e-66 1.00
JAK1_HUMAN JAK1 Tyrosine-protein kinase JAK1 3.217e-65 1.00
TYK2_HUMAN TYK2 Non-receptor tyrosine-protein kinase TYK2 1.434e-57 1.00
JAK2_HUMAN JAK2 Tyrosine-protein kinase JAK2 3.343e-55 1.00
VRK2_HUMAN VRK2 Serine/threonine-protein kinase VRK2 6.524e-44 1.00
NEK3_HUMAN NEK3 Serine/threonine-protein kinase Nek3 2.191e-35 1.00
M3K15_HUMAN MAP3K15 Mitogen-activated protein kinase kinase kinase 15 3.937e-30 1.00
CSKP_HUMAN CASK Peripheral plasma membrane protein CASK 4.419e-25 1.00
MAST1_HUMAN MAST1 Microtubule-associated serine/threonine-protein kinase 1 4.419e-25 1.00
OXSR1_HUMAN OXSR1 Serine/threonine-protein kinase OSR1 4.419e-25 1.00
STK39_HUMAN STK39 STE20/SPS1-related proline-alanine-rich protein kinase 4.419e-25 1.00
DCLK2_HUMAN DCLK2 Serine/threonine-protein kinase DCLK2 7.773e-24 1.00
NEK7_HUMAN NEK7 Serine/threonine-protein kinase Nek7 9.712e-23 1.00
SBK3_HUMAN SBK3 Uncharacterized serine/threonine-protein kinase SBK3 9.712e-23 1.00
SIK3_HUMAN SIK3 Serine/threonine-protein kinase SIK3 9.712e-23 1.00
M3K1_HUMAN MAP3K1 Mitogen-activated protein kinase kinase kinase 1 9.163e-22 1.00
ULK3_HUMAN ULK3 Serine/threonine-protein kinase ULK3 2.976e-21 1.00
DMPK_HUMAN DMPK Myotonin-protein kinase 1.043e-20 1.00
KCC1G_HUMAN CAMK1G Calcium/calmodulin-dependent protein kinase type 1G 4.197e-20 1.00
SBK1_HUMAN SBK1 Serine/threonine-protein kinase SBK1 4.197e-20 1.00
DCLK3_HUMAN DCLK3 Serine/threonine-protein kinase DCLK3 1.016e-19 1.00
PAK6_HUMAN PAK6 Serine/threonine-protein kinase PAK 6 2.176e-19 1.00
RIPK4_HUMAN RIPK4 Receptor-interacting serine/threonine-protein kinase 4 2.176e-19 1.00
GRK7_HUMAN GRK7 Rhodopsin kinase GRK7 7.622e-19 1.00
BMP2K_HUMAN BMP2K BMP-2-inducible protein kinase 4.603e-18 1.00
KS6A6_HUMAN RPS6KA6 Ribosomal protein S6 kinase alpha-6 4.603e-18 1.00
NUAK2_HUMAN NUAK2 NUAK family SNF1-like kinase 2 2.319e-17 1.00
ANKK1_HUMAN ANKK1 Ankyrin repeat and protein kinase domain-containing protein 1 4.449e-17 1.00
PAK5_HUMAN PAK5 Serine/threonine-protein kinase PAK 5 4.449e-17 1.00
STK25_HUMAN STK25 Serine/threonine-protein kinase 25 1.11e-16 1.00
RIOK1_HUMAN RIOK1 Serine/threonine-protein kinase RIO1 3.331e-16 1.00
RIOK2_HUMAN RIOK2 Serine/threonine-protein kinase RIO2 3.331e-16 1.00
RIOK3_HUMAN RIOK3 Serine/threonine-protein kinase RIO3 3.331e-16 1.00
BMPR2_HUMAN BMPR2 Bone morphogenetic protein receptor type-2 8.882e-16 1.00
SRPK3_HUMAN SRPK3 SRSF protein kinase 3 8.882e-16 1.00
KCC2A_HUMAN CAMK2A Calcium/calmodulin-dependent protein kinase type II subunit alpha 1.443e-15 1.00
GRK1_HUMAN GRK1 Rhodopsin kinase GRK1 2.22e-15 1.00
GRK4_HUMAN GRK4 G protein-coupled receptor kinase 4 2.22e-15 1.00
ULK1_HUMAN ULK1 Serine/threonine-protein kinase ULK1 5.218e-15 1.00
MP2K3_HUMAN MAP2K3 Dual specificity mitogen-activated protein kinase kinase 3 1.144e-14 1.00
PHKG1_HUMAN PHKG1 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 1.144e-14 1.00
ULK2_HUMAN ULK2 Serine/threonine-protein kinase ULK2 1.144e-14 1.00
M3K3_HUMAN MAP3K3 Mitogen-activated protein kinase kinase kinase 3 2.387e-14 1.00
MP2K4_HUMAN MAP2K4 Dual specificity mitogen-activated protein kinase kinase 4 2.387e-14 1.00
KCC1D_HUMAN CAMK1D Calcium/calmodulin-dependent protein kinase type 1D 2.831e-14 1.00
DAPK2_HUMAN DAPK2 Death-associated protein kinase 2 9.259e-14 1.00
TAOK2_HUMAN TAOK2 Serine/threonine-protein kinase TAO2 9.259e-14 1.00
STK16_HUMAN STK16 Serine/threonine-protein kinase 16 1.731e-13 1.00
DAPK1_HUMAN DAPK1 Death-associated protein kinase 1 3.137e-13 1.00
HIPK3_HUMAN HIPK3 Homeodomain-interacting protein kinase 3 5.523e-13 1.00
M3K2_HUMAN MAP3K2 Mitogen-activated protein kinase kinase kinase 2 5.523e-13 1.00
STK26_HUMAN STK26 Serine/threonine-protein kinase 26 5.523e-13 1.00
BMR1B_HUMAN BMPR1B Bone morphogenetic protein receptor type-1B 4.142e-12 1.00
HIPK1_HUMAN HIPK1 Homeodomain-interacting protein kinase 1 1.001e-11 1.00
AAK1_HUMAN AAK1 AP2-associated protein kinase 1 3.307e-11 1.00
EPHB6_HUMAN EPHB6 Ephrin type-B receptor 6 3.307e-11 1.00
DCLK1_HUMAN DCLK1 Serine/threonine-protein kinase DCLK1 8.563e-11 1.00
PKNB_MYCTU pknB Serine/threonine-protein kinase PknB 8.563e-11 1.00
KS6A4_HUMAN RPS6KA4 Ribosomal protein S6 kinase alpha-4 2.504e-10 1.00
EPHA3_HUMAN EPHA3 Ephrin type-A receptor 3 4.504e-10 1.00
MP2K2_HUMAN MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 5.503e-10 1.00
GRK5_HUMAN GRK5 G protein-coupled receptor kinase 5 1.88e-09 1.00
M3K19_HUMAN MAP3K19 Mitogen-activated protein kinase kinase kinase 19 2.698e-09 1.00
KCC1A_HUMAN CAMK1 Calcium/calmodulin-dependent protein kinase type 1 4.372e-09 1.00
KS6A1_HUMAN RPS6KA1 Ribosomal protein S6 kinase alpha-1 1.125e-08 1.00
LTK_HUMAN LTK Leukocyte tyrosine kinase receptor 1.835e-08 1.00
MYLK_HUMAN MYLK Myosin light chain kinase, smooth muscle 1.318e-07 1.00
ST17B_HUMAN STK17B Serine/threonine-protein kinase 17B 2.227e-07 1.00
GAK_HUMAN GAK Cyclin-G-associated kinase 3.215e-07 1.00
KGP2_HUMAN PRKG2 cGMP-dependent protein kinase 2 3.215e-07 1.00
AURKC_HUMAN AURKC Aurora kinase C 3.618e-07 1.00
PLK2_HUMAN PLK2 Serine/threonine-protein kinase PLK2 1.851e-06 1.00
TAOK3_HUMAN TAOK3 Serine/threonine-protein kinase TAO3 2.404e-06 1.00
DAPK3_HUMAN DAPK3 Death-associated protein kinase 3 6.75e-06 1.00
MARK2_HUMAN MARK2 Serine/threonine-protein kinase MARK2 1.169e-05 1.00
PHKG2_HUMAN PHKG2 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 1.363e-05 1.00
PAK4_HUMAN PAK4 Serine/threonine-protein kinase PAK 4 1.538e-05 1.00
KAPCA_HUMAN PRKACA cAMP-dependent protein kinase catalytic subunit alpha 1.724e-05 1.00
KCC2B_HUMAN CAMK2B Calcium/calmodulin-dependent protein kinase type II subunit beta 2.056e-05 1.00
CDK7_HUMAN CDK7 Cyclin-dependent kinase 7 2.55e-05 1.00
KS6A5_HUMAN RPS6KA5 Ribosomal protein S6 kinase alpha-5 2.911e-05 1.00
PI4KB_HUMAN PI4KB Phosphatidylinositol 4-kinase beta 3.552e-05 1.00
KC1A_HUMAN CSNK1A1 Casein kinase I isoform alpha 3.613e-05 1.00
CLK2_HUMAN CLK2 Dual specificity protein kinase CLK2 7.29e-05 1.00
AAPK1_HUMAN PRKAA1 5'-AMP-activated protein kinase catalytic subunit alpha-1 8.273e-05 1.00
DYRK2_HUMAN DYRK2 Dual specificity tyrosine-phosphorylation-regulated kinase 2 8.415e-05 1.00
DYR1B_HUMAN DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B 8.457e-05 1.00
KCC2D_HUMAN CAMK2D Calcium/calmodulin-dependent protein kinase type II subunit delta 9.439e-05 1.00
KS6A2_HUMAN RPS6KA2 Ribosomal protein S6 kinase alpha-2 0.0002763 1.00
IRAK1_HUMAN IRAK1 Interleukin-1 receptor-associated kinase 1 0.0002766 1.00
FYN_HUMAN FYN Tyrosine-protein kinase Fyn 0.0003139 1.00
ST17A_HUMAN STK17A Serine/threonine-protein kinase 17A 0.0003298 1.00
SRPK1_HUMAN SRPK1 SRSF protein kinase 1 0.0003531 1.00
CDK8_HUMAN CDK8 Cyclin-dependent kinase 8 0.0003742 1.00
KCC2G_HUMAN CAMK2G Calcium/calmodulin-dependent protein kinase type II subunit gamma 0.0003744 1.00
CLK4_HUMAN CLK4 Dual specificity protein kinase CLK4 0.0004093 1.00
KPCD3_HUMAN PRKD3 Serine/threonine-protein kinase D3 0.000421 1.00
M3K7_HUMAN MAP3K7 Mitogen-activated protein kinase kinase kinase 7 0.0004316 1.00
RET_HUMAN RET Proto-oncogene tyrosine-protein kinase receptor Ret 0.0005882 1.00
M4K2_HUMAN MAP4K2 Mitogen-activated protein kinase kinase kinase kinase 2 0.0006527 1.00
ROCK1_HUMAN ROCK1 Rho-associated protein kinase 1 0.000723 1.00
NTRK2_HUMAN NTRK2 BDNF/NT-3 growth factors receptor 0.0008277 1.00
M4K4_HUMAN MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4 0.001259 1.00
CSK22_HUMAN CSNK2A2 Casein kinase II subunit alpha' 0.001381 1.00
ACK1_HUMAN TNK2 Activated CDC42 kinase 1 0.001465 1.00
NTRK3_HUMAN NTRK3 NT-3 growth factor receptor 0.001649 1.00
GSK3A_HUMAN GSK3A Glycogen synthase kinase-3 alpha 0.001703 1.00
PLK3_HUMAN PLK3 Serine/threonine-protein kinase PLK3 0.001813 1.00
IKKE_HUMAN IKBKE Inhibitor of nuclear factor kappa-B kinase subunit epsilon 0.001871 1.00
PLK4_HUMAN PLK4 Serine/threonine-protein kinase PLK4 0.002 1.00
TAOK1_HUMAN TAOK1 Serine/threonine-protein kinase TAO1 0.002242 1.00
HIPK2_HUMAN HIPK2 Homeodomain-interacting protein kinase 2 0.002454 1.00
AURKA_HUMAN AURKA Aurora kinase A 0.002816 1.00
MP2K1_HUMAN MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 0.00315 1.00
KPCE_HUMAN PRKCE Protein kinase C epsilon type 0.003996 1.00
LRRK2_HUMAN LRRK2 Leucine-rich repeat serine/threonine-protein kinase 2 0.01404 1.00
ERN1_HUMAN ERN1 Serine/threonine-protein kinase/endoribonuclease IRE1 0.01472 1.00
MKNK2_HUMAN MKNK2 MAP kinase-interacting serine/threonine-protein kinase 2 0.01742 1.00
DYR1A_HUMAN DYRK1A Dual specificity tyrosine-phosphorylation-regulated kinase 1A 0.0261 1.00
ROCK2_HUMAN ROCK2 Rho-associated protein kinase 2 0.04196 1.00
ALK_HUMAN ALK ALK tyrosine kinase receptor 0.0497 1.00
TBK1_HUMAN TBK1 Serine/threonine-protein kinase TBK1 0.05133 1.00
IKKB_HUMAN IKBKB Inhibitor of nuclear factor kappa-B kinase subunit beta 0.05729 1.00
PLK1_HUMAN PLK1 Serine/threonine-protein kinase PLK1 0.08118 1.00
FAK1_HUMAN PTK2 Focal adhesion kinase 1 0.1075 1.00
CSK21_HUMAN CSNK2A1 Casein kinase II subunit alpha 0.1177 1.00
GSK3B_HUMAN GSK3B Glycogen synthase kinase-3 beta 0.1653 1.00
TTK_HUMAN TTK Dual specificity protein kinase TTK 0.1917 1.00
MELK_HUMAN MELK Maternal embryonic leucine zipper kinase 0.1953 1.00
LCK_HUMAN LCK Tyrosine-protein kinase Lck 0.2005 1.00
ABL1_HUMAN ABL1 Tyrosine-protein kinase ABL1 0.2045 1.00
AURKB_HUMAN AURKB Aurora kinase B 0.2231 1.00
MK08_HUMAN MAPK8 Mitogen-activated protein kinase 8 0.247 1.00
KIT_HUMAN KIT Mast/stem cell growth factor receptor Kit 0.3884 1.00
FGFR1_HUMAN FGFR1 Fibroblast growth factor receptor 1 0.3944 1.00
NTRK1_HUMAN NTRK1 High affinity nerve growth factor receptor 0.7843 1.00
BRAF_HUMAN BRAF Serine/threonine-protein kinase B-raf 0.9819 1.00
JAK3_RAT Jak3 Tyrosine-protein kinase JAK3 1.713e-41 0.33
JAK2_MOUSE Jak2 Tyrosine-protein kinase JAK2 2.122e-13 0.33
SYTC_HUMAN TARS1 Threonine--tRNA ligase 1, cytoplasmic 5.582e-12 0.32
SYT_YERPE thrS Threonine--tRNA ligase 5.582e-12 0.32
TPX2_HUMAN TPX2 Targeting protein for Xklp2 2.335e-11 0.33
JAK3_MOUSE Jak3 Tyrosine-protein kinase JAK3 3.177e-11 0.33

Fingolimod

S1PR3_HUMAN S1PR3 Sphingosine 1-phosphate receptor 3 2.414e-64 1.00
S1PR4_HUMAN S1PR4 Sphingosine 1-phosphate receptor 4 4.831e-61 1.00
S1PR5_HUMAN S1PR5 Sphingosine 1-phosphate receptor 5 8.55e-51 1.00
S1PR1_HUMAN S1PR1 Sphingosine 1-phosphate receptor 1 3.392e-49 1.00
SPHK1_HUMAN SPHK1 Sphingosine kinase 1 3.34e-81 0.47
SPHK2_MOUSE Sphk2 Sphingosine kinase 2 7.292e-81 0.41
AKT1_MOUSE Akt1 RAC-alpha serine/threonine-protein kinase 1.353e-66 0.38
LOX15_PIG ALOX15 Arachidonate 15-lipoxygenase 4.136e-59 0.32
LPXC_AQUAE lpxC UDP-3-O-acyl-N-acetylglucosamine deacetylase 5.977e-54 0.33
SPHK2_HUMAN SPHK2 Sphingosine kinase 2 2.599e-51 0.43
S1PR2_HUMAN S1PR2 Sphingosine 1-phosphate receptor 2 3.75e-51 0.72
PA24A_HUMAN PLA2G4A Cytosolic phospholipase A2 1.456e-49 0.37
PLM2_PLAFA Plasmepsin-2 1.141e-43 0.36
UNG_HUMAN UNG Uracil-DNA glycosylase 6.812e-43 0.35
GOB1_BRUMA Trehalose-phosphatase 3.543e-39 0.31
PLCG1_BOVIN PLCG1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 2.754e-36 0.36
INHA_MYCTU inhA Enoyl-[acyl-carrier-protein] reductase [NADH] 7.08e-32 0.38
RARB_HUMAN RARB Retinoic acid receptor beta 5.451e-29 0.53
ENPP2_MOUSE Enpp2 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 7.039e-27 0.38
M9TGV3_MYCTX inhA Enoyl-[acyl-carrier-protein] reductase [NADH] 5.27e-25 0.35
PTPRO_HUMAN PTPRO Receptor-type tyrosine-protein phosphatase O 3.556e-23 0.35
NU1M_BOVIN MT-ND1 NADH-ubiquinone oxidoreductase chain 1 1.818e-19 0.37
SPTC2_HUMAN SPTLC2 Serine palmitoyltransferase 2 2.375e-18 0.29
PA24B_HUMAN PLA2G4B Cytosolic phospholipase A2 beta 1.844e-17 0.30
S1PR1_RAT S1pr1 Sphingosine 1-phosphate receptor 1 1.11e-16 0.68
SCN2A_RAT Scn2a Sodium channel protein type 2 subunit alpha 1.11e-16 0.47
G3PG_TRYCR Glyceraldehyde-3-phosphate dehydrogenase, glycosomal 2.22e-16 0.31
GPAT1_MOUSE Gpam Glycerol-3-phosphate acyltransferase 1, mitochondrial 5.551e-16 0.30
FUT7_HUMAN FUT7 Alpha-(1,3)-fucosyltransferase 7 1.665e-15 0.34
E3UJZ5_SPOLI Ecdysone receptor 1.998e-15 0.35
LPAR3_RAT Lpar3 Lysophosphatidic acid receptor 3 6.328e-15 0.33
TRPM2_HUMAN TRPM2 Transient receptor potential cation channel subfamily M member 2 1.463e-13 0.33
TLR8_HUMAN TLR8 Toll-like receptor 8 1.518e-13 0.34
FAAH1_RAT Faah Fatty-acid amide hydrolase 1 1.662e-13 0.47
LOX15_RABIT ALOX15 Arachidonate 15-lipoxygenase 3.506e-13 0.55
DRTS_LEIMA Bifunctional dihydrofolate reductase-thymidylate synthase 1.765e-12 0.31
TRPV2_RAT Trpv2 Transient receptor potential cation channel subfamily V member 2 5.082e-12 0.29
YOPH_YEREN yopH Tyrosine-protein phosphatase YopH 8.017e-12 0.29
THB_HUMAN THRB Thyroid hormone receptor beta 1.672e-11 0.47
LPAR2_HUMAN LPAR2 Lysophosphatidic acid receptor 2 4.073e-11 0.39
PP1G_HUMAN PPP1CC Serine/threonine-protein phosphatase PP1-gamma catalytic subunit 9.3e-11 0.29
GGPPS_HUMAN GGPS1 Geranylgeranyl pyrophosphate synthase 1.668e-10 0.37
MEP2_YEAST MEP2 Ammonium transporter MEP2 2.244e-10 0.30
KCNK2_HUMAN KCNK2 Potassium channel subfamily K member 2 6.811e-10 0.31
NANA_STREE nanA Sialidase A 9.46e-10 0.28
TPOR_HUMAN MPL Thrombopoietin receptor 1.311e-09 0.33
PPO2_AGABI PPO2 Polyphenol oxidase 2 1.648e-09 0.40
DOPO_RAT Dbh Dopamine beta-hydroxylase 1.705e-09 0.32
PE2R2_RAT Ptger2 Prostaglandin E2 receptor EP2 subtype 2.876e-09 0.31
THA_HUMAN THRA Thyroid hormone receptor alpha 3.039e-09 0.46
Q9RMS5_PSEAI phzR LuxR family transcriptional regulator 3.426e-09 0.37
P2RX1_MOUSE P2rx1 P2X purinoceptor 1 3.598e-09 0.29
MMP25_HUMAN MMP25 Matrix metalloproteinase-25 4.226e-09 0.28
DYR_CHICK DHFR Dihydrofolate reductase 4.973e-09 0.38
Q8ST54_TRYCR HK Phosphotransferase 5.501e-09 0.41
LOX15_RAT Alox15 Arachidonate 15-lipoxygenase 1.381e-08 0.30
Q95214_RABIT ACAT Acyl-CoA:cholesterol acyltransferase 2.642e-08 0.35
A0A072ZLE6_PSEAI mvfR LysR family transcriptional regulator 3.985e-08 0.29
ECR_BOMMO EcR Ecdysone receptor 4.784e-08 0.35
DYR_ECOLI folA Dihydrofolate reductase 7.19e-08 0.31
LPAR1_RAT Lpar1 Lysophosphatidic acid receptor 1 1.258e-07 0.33
DHB3_HUMAN HSD17B3 Testosterone 17-beta-dehydrogenase 3 5.047e-07 0.31
FPPS_HUMAN FDPS Farnesyl pyrophosphate synthase 1.195e-06 0.33
NR1H4_MOUSE Nr1h4 Bile acid receptor 1.454e-06 0.31
O49150_SOLTU Lipoxygenase 2.226e-06 0.31
Q9K2N0_PSEAI blaVIM-2 Beta-lactamase class B VIM-2 3.272e-06 0.28
Q8MWR1_SPOFR USP Ultraspiracle protein 4.159e-06 0.31
Q8MWR2_SPOFR EcR Ecdysteroid receptor 4.159e-06 0.31
DYR_LACCA folA Dihydrofolate reductase 4.871e-06 0.38
MDHC_HUMAN MDH1 Malate dehydrogenase, cytoplasmic 5.235e-06 0.29
NAAA_HUMAN NAAA N-acylethanolamine-hydrolyzing acid amidase 8.65e-06 0.30
TAOK3_HUMAN TAOK3 Serine/threonine-protein kinase TAO3 8.792e-06 0.31

Ticagrelor

P2Y12_RAT P2ry12 P2Y purinoceptor 12 1.794e-62 1.00
P2Y12_HUMAN P2RY12 P2Y purinoceptor 12 4.98e-21 1.00

Sulthiame

CAH2_HUMAN CA2 Carbonic anhydrase 2 3.372e-60 1.00
CAH1_HUMAN CA1 Carbonic anhydrase 1 4.609e-60 1.00
Q5U9J1_THAWE ca1 Delta carbonic anhydrase 1.062e-59 1.00
CAH9_HUMAN CA9 Carbonic anhydrase 9 1.449e-59 1.00
C0IX24_STYPI CA2 Carbonic anhydrase 8.242e-59 1.00
B2V8E3_SULSY Carbonate dehydratase 4.04e-57 1.00
Q31FD6_HYDCU Carbonic anhydrase, alpha family 4.04e-57 1.00
B5SU02_STYPI CA Alpha carbonic anhydrase 1.516e-56 1.00
MTCA1_MYCTU mtcA1 Beta-carbonic anhydrase 1 5.31e-52 1.00
A6YCJ1_9METZ Astrosclerin-3 2.441e-47 1.00
CAN_YEAST NCE103 Carbonic anhydrase 1.297e-46 1.00
Q5TU56_ANOGA 1272966 Carbonic anhydrase 8.489e-42 1.00
CAH15_MOUSE Ca15 Carbonic anhydrase 15 3.1e-34 1.00
MTCA2_MYCTU mtcA2 Carbonic anhydrase 2 1.279e-28 1.00
CAN_CANAL NCE103 Carbonic anhydrase 1.076e-26 1.00
CAH6_HUMAN CA6 Carbonic anhydrase 6 1.48e-22 1.00
CAH2_BOVIN CA2 Carbonic anhydrase 2 2.524e-59 0.41
CAH12_HUMAN CA12 Carbonic anhydrase 12 1.645e-53 0.44
CYNT_HELPY cynT Carbonic anhydrase 1.02e-41 0.37
CAH_METTE Carbonic anhydrase 1.921e-40 0.37
PGH2_HUMAN PTGS2 Prostaglandin G/H synthase 2 9.027e-38 0.37
CAH7_HUMAN CA7 Carbonic anhydrase 7 6.439e-35 0.37
Q6FTL6_CANGA NCE103 Carbonic anhydrase 3.324e-33 0.37
Q3I4V7_CRYNV CAN2 Carbonic anhydrase 4.913e-32 0.37
P96878_MYCTU Probable transmembrane carbonic anhydrase (Carbonate dehydratase) (Carbonic dehydratase) 1.205e-31 0.37
CAH5B_HUMAN CA5B Carbonic anhydrase 5B, mitochondrial 5.146e-30 0.37
CAH14_HUMAN CA14 Carbonic anhydrase 14 1.201e-28 0.41
CAH5A_HUMAN CA5A Carbonic anhydrase 5A, mitochondrial 9.705e-28 0.41
PGH1_HUMAN PTGS1 Prostaglandin G/H synthase 1 1.999e-26 0.34
CALCA_RAT Calca Calcitonin gene-related peptide 1 6.377e-23 0.28
CAH4_HUMAN CA4 Carbonic anhydrase 4 1.43e-22 0.37
PGH2_MOUSE Ptgs2 Prostaglandin G/H synthase 2 2.791e-21 0.34
CAH13_MOUSE Ca13 Carbonic anhydrase 13 1.11e-16 0.37
CAH4_BOVIN CA4 Carbonic anhydrase 4 3.331e-16 0.37
PGH1_SHEEP PTGS1 Prostaglandin G/H synthase 1 8.882e-16 0.33
PGH2_RAT Ptgs2 Prostaglandin G/H synthase 2 2.654e-12 0.30
YOPH_YEREN yopH Tyrosine-protein phosphatase YopH 1.23e-11 0.28
CAH3_HUMAN CA3 Carbonic anhydrase 3 4.155e-11 0.37
PPBT_BOVIN ALPL Alkaline phosphatase, tissue-nonspecific isozyme 4.999e-11 0.32
PGH2_SHEEP PTGS2 Prostaglandin G/H synthase 2 2.526e-10 0.40
CAH13_HUMAN CA13 Carbonic anhydrase 13 4.905e-10 0.37
KAT2A_HUMAN KAT2A Histone acetyltransferase KAT2A 1.566e-08 0.28
SL9A3_HUMAN SLC9A3 Sodium/hydrogen exchanger 3 4.326e-07 0.33
CDK4_HUMAN CDK4 Cyclin-dependent kinase 4 4.843e-07 0.37
CDK1_HUMAN CDK1 Cyclin-dependent kinase 1 8.696e-07 0.37
PPBI_BOVIN ALPI Intestinal-type alkaline phosphatase 1.001e-06 0.32

Ivacaftor

CFTR_HUMAN CFTR Cystic fibrosis transmembrane conductance regulator 3.449e-57 1.00
CP51_TRYCC CYP51 Sterol 14-alpha demethylase 9.23e-102 0.32
NMBR_HUMAN NMBR Neuromedin-B receptor 1.193e-58 0.35
GRPR_HUMAN GRPR Gastrin-releasing peptide receptor 9.207e-52 0.31
MDHM_PIG MDH2 Malate dehydrogenase, mitochondrial 1.143e-45 0.32
GBRA1_RAT Gabra1 Gamma-aminobutyric acid receptor subunit alpha-1 2.343e-45 0.35
GBRB2_RAT Gabrb2 Gamma-aminobutyric acid receptor subunit beta-2 1.636e-44 0.35
GBRG2_RAT Gabrg2 Gamma-aminobutyric acid receptor subunit gamma-2 3.708e-41 0.35
RUVB1_HUMAN RUVBL1 RuvB-like 1 9.681e-38 0.30
KCMA1_HUMAN KCNMA1 Calcium-activated potassium channel subunit alpha-1 1.259e-37 0.32
GBRA2_RAT Gabra2 Gamma-aminobutyric acid receptor subunit alpha-2 5.442e-37 0.35
IL1RA_MOUSE Il1rn Interleukin-1 receptor antagonist protein 2.43e-36 0.29
BGLR_HUMAN GUSB Beta-glucuronidase 9.31e-35 0.34
GBRA5_RAT Gabra5 Gamma-aminobutyric acid receptor subunit alpha-5 2.175e-33 0.35
GBRB3_RAT Gabrb3 Gamma-aminobutyric acid receptor subunit beta-3 6.569e-33 0.35
GBRB2_HUMAN GABRB2 Gamma-aminobutyric acid receptor subunit beta-2 5.458e-27 0.43
GBRB1_HUMAN GABRB1 Gamma-aminobutyric acid receptor subunit beta-1 3.623e-26 0.35
PARP2_MOUSE Parp2 Poly [ADP-ribose] polymerase 2 1.444e-25 0.34
NMBR_RAT Nmbr Neuromedin-B receptor 2.656e-24 0.30
ACHA7_MOUSE Chrna7 Neuronal acetylcholine receptor subunit alpha-7 2.366e-23 0.33
CP125_MYCTU cyp125 Steroid C26-monooxygenase 5.518e-23 0.28
AAKB2_HUMAN PRKAB2 5'-AMP-activated protein kinase subunit beta-2 6.697e-20 0.32
MMP8_RAT Mmp8 Neutrophil collagenase 1.009e-18 0.31
S15A2_RAT Slc15a2 Solute carrier family 15 member 2 3.448e-18 0.32
ECE1_BOVIN ECE1 Endothelin-converting enzyme 1 4.879e-18 0.29
GBRA3_RAT Gabra3 Gamma-aminobutyric acid receptor subunit alpha-3 2.273e-17 0.30
ERAP2_HUMAN ERAP2 Endoplasmic reticulum aminopeptidase 2 1.11e-16 0.31
LCAP_HUMAN LNPEP Leucyl-cystinyl aminopeptidase 1.11e-16 0.31
HES1_MOUSE Hes1 Transcription factor HES-1 1.887e-15 0.29
NCOR1_HUMAN NCOR1 Nuclear receptor corepressor 1 2.331e-15 0.31
ECE1_HUMAN ECE1 Endothelin-converting enzyme 1 2.665e-15 0.33
DPOL_HHV11 DNA polymerase catalytic subunit 3.442e-15 0.33
DPOL_VZVD DNA polymerase catalytic subunit 3.442e-15 0.33
SIA4A_HUMAN ST3GAL1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 3.553e-15 0.29
NR1H4_HUMAN NR1H4 Bile acid receptor 7.327e-15 0.34
SPRE_HUMAN SPR Sepiapterin reductase 1.688e-14 0.28
GASR_MOUSE Cckbr Gastrin/cholecystokinin type B receptor 4.974e-14 0.32
ADA12_HUMAN ADAM12 Disintegrin and metalloproteinase domain-containing protein 12 8.293e-14 0.30
THER_BACTH npr Thermolysin 9.959e-14 0.30
ERAP1_HUMAN ERAP1 Endoplasmic reticulum aminopeptidase 1 1.159e-13 0.31
ELAS_PSEAE lasB Elastase 1.464e-13 0.31
NEP_RABIT MME Neprilysin 1.952e-13 0.30
ECE1_RAT Ece1 Endothelin-converting enzyme 1 2.516e-13 0.30
RXFP1_HUMAN RXFP1 Relaxin receptor 1 2.925e-13 0.31
BODG_PSESK Gamma-butyrobetaine dioxygenase 3.23e-13 0.29
IMDH2_HUMAN IMPDH2 Inosine-5'-monophosphate dehydrogenase 2 6.287e-13 0.40
Q5NGQ3_FRATT fabI Enoyl-[acyl-carrier-protein] reductase [NADH] 1.17e-11 0.28
GBRA1_HUMAN GABRA1 Gamma-aminobutyric acid receptor subunit alpha-1 3.532e-11 0.43
CAN1_RAT Capn1 Calpain-1 catalytic subunit 5.932e-11 0.29
STK33_HUMAN STK33 Serine/threonine-protein kinase 33 1.236e-10 0.29
JAK3_MOUSE Jak3 Tyrosine-protein kinase JAK3 2.015e-10 0.30
CCKAR_RAT Cckar Cholecystokinin receptor type A 2.552e-10 0.38
NEP_PIG MME Neprilysin 2.659e-10 0.30
AA1R_BOVIN ADORA1 Adenosine receptor A1 3.218e-10 0.34
MTSI_SPISQ sssIM CPG DNA methylase 5.888e-10 0.31
KI20A_HUMAN KIF20A Kinesin-like protein KIF20A 6.439e-10 0.29
GBRG2_HUMAN GABRG2 Gamma-aminobutyric acid receptor subunit gamma-2 1.218e-09 0.43
NK1R_HUMAN TACR1 Substance-P receptor 2.242e-09 0.32
PAFA_HUMAN PLA2G7 Platelet-activating factor acetylhydrolase 2.449e-09 0.35
MMP8_HUMAN MMP8 Neutrophil collagenase 2.876e-09 0.31
TYTR_TRYCR TPR Trypanothione reductase 3.766e-09 0.34
TIMP3_RAT Timp3 Metalloproteinase inhibitor 3 7.476e-09 0.31
MMP9_RAT Mmp9 Matrix metalloproteinase-9 2.38e-08 0.31
MMP9_HUMAN MMP9 Matrix metalloproteinase-9 3.146e-08 0.32
HDAC2_HUMAN HDAC2 Histone deacetylase 2 3.229e-08 0.33
CCKAR_CAVPO CCKAR Cholecystokinin receptor type A 6.215e-08 0.33
MMP26_HUMAN MMP26 Matrix metalloproteinase-26 1.028e-07 0.30
HDAC3_HUMAN HDAC3 Histone deacetylase 3 1.18e-07 0.34
CATL1_HUMAN CTSL Cathepsin L1 1.691e-07 0.33
5HT3A_CAVPO HTR3A 5-hydroxytryptamine receptor 3A 1.713e-07 0.31
ACE_RAT Ace Angiotensin-converting enzyme 2.899e-07 0.29
MMP7_HUMAN MMP7 Matrilysin 3.16e-07 0.38
MMP2_HUMAN MMP2 72 kDa type IV collagenase 4.414e-07 0.38
A0A0C7ACN7_PSEAI pqsD 3-oxoacyl-ACP synthase 5.631e-07 0.30
BRS3_HUMAN BRS3 Bombesin receptor subtype-3 8.153e-07 0.31
I23O1_HUMAN IDO1 Indoleamine 2,3-dioxygenase 1 1.763e-06 0.32
MMP17_HUMAN MMP17 Matrix metalloproteinase-17 2.346e-06 0.30
Q7ZJM1_9HIV1 pol Integrase 2.47e-06 0.36
MMP15_HUMAN MMP15 Matrix metalloproteinase-15 3.716e-06 0.30
MMP1_HUMAN MMP1 Interstitial collagenase 5.588e-06 0.38
ACE_HUMAN ACE Angiotensin-converting enzyme 6.291e-06 0.32
NK2R_MESAU TACR2 Substance-K receptor 8.919e-06 0.29
CATB_HUMAN CTSB Cathepsin B 9.261e-06 0.33
WDR5_HUMAN WDR5 WD repeat-containing protein 5 9.949e-06 0.30

Rilpivirine

Q9WKE8_9HIV1 reverse transcriptase Reverse transcriptase 1.716e-54 1.00
Q9WJQ2_9HIV1 reverse transcriptase Reverse transcriptase protein 5.421e-07 1.00
LCK_MOUSE Lck Proto-oncogene tyrosine-protein kinase LCK 9.419e-85 0.37
MRP3_HUMAN ABCC3 Canalicular multispecific organic anion transporter 2 4.407e-45 0.36
PLK1_HUMAN PLK1 Serine/threonine-protein kinase PLK1 3.079e-23 0.39
EPHB4_HUMAN EPHB4 Ephrin type-B receptor 4 5.587e-21 0.48
AURKA_HUMAN AURKA Aurora kinase A 2.787e-13 0.41
IKKE_HUMAN IKBKE Inhibitor of nuclear factor kappa-B kinase subunit epsilon 8.774e-13 0.31
TXK_HUMAN TXK Tyrosine-protein kinase TXK 2.437e-12 0.35
DKK1_HUMAN DKK1 Dickkopf-related protein 1 3.144e-12 0.30
JAK3_MOUSE Jak3 Tyrosine-protein kinase JAK3 1.231e-11 0.34
CDK4_HUMAN CDK4 Cyclin-dependent kinase 4 1.437e-10 0.39
TBK1_HUMAN TBK1 Serine/threonine-protein kinase TBK1 7.51e-10 0.31
RAC1_HUMAN RAC1 Ras-related C3 botulinum toxin substrate 1 1.104e-09 0.28
CDK2_HUMAN CDK2 Cyclin-dependent kinase 2 1.356e-09 0.44
MRP2_HUMAN ABCC2 Canalicular multispecific organic anion transporter 1 1.78e-09 0.36
RPGF4_HUMAN RAPGEF4 Rap guanine nucleotide exchange factor 4 1.594e-08 0.31
COQ8B_HUMAN COQ8B Atypical kinase COQ8B, mitochondrial 2.719e-08 0.34
EPHB2_HUMAN EPHB2 Ephrin type-B receptor 2 4.143e-08 0.34
IGF1R_HUMAN IGF1R Insulin-like growth factor 1 receptor 7.11e-08 0.37
MK08_HUMAN MAPK8 Mitogen-activated protein kinase 8 1.346e-06 0.36
KC1G2_HUMAN CSNK1G2 Casein kinase I isoform gamma-2 1.441e-06 0.34
AURKB_HUMAN AURKB Aurora kinase B 1.671e-06 0.35

Dolutegravir

Q76353_9HIV1 Integrase 4.332e-53 1.00
VACHT_RAT Slc18a3 Vesicular acetylcholine transporter 4.711e-08 1.00
SGMR2_RAT Tmem97 Sigma intracellular receptor 2 4.237e-06 1.00
SGMR1_RAT Sigmar1 Sigma non-opioid intracellular receptor 1 0.1211 1.00
SGMR1_CAVPO SIGMAR1 Sigma non-opioid intracellular receptor 1 0.5063 1.00
GLYCP_NIPAV G Glycoprotein G 1.5e-68 0.35
DPOL_HHV11 DNA polymerase catalytic subunit 1.195e-39 0.31
DPOL_VZVD DNA polymerase catalytic subunit 1.195e-39 0.31
P2RX7_HUMAN P2RX7 P2X purinoceptor 7 5.125e-33 0.37
DPOL_HCMVA UL54 DNA polymerase catalytic subunit 1.288e-25 0.31
Q7ZJM1_9HIV1 pol Integrase 3.012e-17 0.36
KCNK3_HUMAN KCNK3 Potassium channel subfamily K member 3 5.965e-09 0.42
CNR1_MOUSE Cnr1 Cannabinoid receptor 1 5.111e-08 0.30
DPOLA_HUMAN POLA1 DNA polymerase alpha catalytic subunit 7.817e-08 0.33
P2RX7_RAT P2rx7 P2X purinoceptor 7 3.103e-06 0.34
CNR2_MOUSE Cnr2 Cannabinoid receptor 2 4.892e-06 0.30

Trametinib

MP2K1_HUMAN MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 2.591e-48 1.00
MP2K2_HUMAN MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 3.517e-05 1.00
MP2K1_MOUSE Map2k1 Dual specificity mitogen-activated protein kinase kinase 1 9.507e-18 0.28

Dimetindene

HRH1_HUMAN HRH1 Histamine H1 receptor 2.548e-45 1.00
ACM5_HUMAN CHRM5 Muscarinic acetylcholine receptor M5 6.081e-39 1.00
ACM4_HUMAN CHRM4 Muscarinic acetylcholine receptor M4 1.846e-35 1.00
ACM1_HUMAN CHRM1 Muscarinic acetylcholine receptor M1 2.441e-26 1.00
ACM1_DROME mAChR-A Muscarinic acetylcholine receptor DM1 7.773e-24 1.00
ACM2_HUMAN CHRM2 Muscarinic acetylcholine receptor M2 9.275e-23 1.00
ACM3_HUMAN CHRM3 Muscarinic acetylcholine receptor M3 1.688e-21 1.00
KCNH2_HUMAN KCNH2 Potassium voltage-gated channel subfamily H member 2 1.859e-07 1.00
CP2CJ_HUMAN CYP2C19 Cytochrome P450 2C19 0.6682 1.00
CP2C9_HUMAN CYP2C9 Cytochrome P450 2C9 0.8885 1.00
PPO1_AGABI PPO1 Polyphenol oxidase 1 9.421e-11 0.34
HRH1_RAT Hrh1 Histamine H1 receptor 3.751e-10 0.33
CXCR4_HUMAN CXCR4 C-X-C chemokine receptor type 4 4.167e-07 0.32

Macitentan

EDNRB_HUMAN EDNRB Endothelin receptor type B 6.571e-44 1.00
EDNRA_HUMAN EDNRA Endothelin-1 receptor 4.649e-28 1.00
EDNRA_PIG EDNRA Endothelin-1 receptor 8.474e-68 0.68
EDNRA_RAT Ednra Endothelin-1 receptor 9.304e-07 0.59

Indoprofen

FABPL_RAT Fabp1 Fatty acid-binding protein, liver 9.538e-42 1.00
LUCI_PHOPY Luciferin 4-monooxygenase 0.03626 1.00
Q9IP65_HCMV US28 G protein-coupled receptor 5.96e-40 0.40
A8PUY1_MALGO LIP1, secretory lipase (Family 3) 3.543e-39 0.31
SCN1A_HUMAN SCN1A Sodium channel protein type 1 subunit alpha 3.497e-35 0.34
SCN9A_MOUSE Scn9a Sodium channel protein type 9 subunit alpha 1.171e-33 0.34
PGH1_RAT Ptgs1 Prostaglandin G/H synthase 1 2.924e-30 0.40
S22A7_RAT Slc22a7 Solute carrier family 22 member 7 3.125e-29 0.36
US28_HCMVA US28 G-protein coupled receptor homolog US28 6.158e-28 0.40
S22A6_RAT Slc22a6 Solute carrier family 22 member 6 6.784e-27 0.39
BLAB_BACCE Metallo-beta-lactamase type 2 1.914e-25 0.29
HELD_ECOLI helD DNA helicase IV 7.635e-24 0.46
M3K5_HUMAN MAP3K5 Mitogen-activated protein kinase kinase kinase 5 6.511e-23 0.42
S22A6_HUMAN SLC22A6 Solute carrier family 22 member 6 9.652e-22 0.40
E1BI31_BOVIN DPP9 Dipeptidyl peptidase 9 6.654e-21 0.33
PGH1_SHEEP PTGS1 Prostaglandin G/H synthase 1 2.48e-20 0.47
S22AK_MOUSE Slc22a20 Solute carrier family 22 member 20 1.805e-17 0.39
IF4H_HUMAN EIF4H Eukaryotic translation initiation factor 4H 7.25e-14 0.33
PEPT1_DERPT DERP1 Peptidase 1 2.015e-13 0.35
VANX_ENTFC vanX D-alanyl-D-alanine dipeptidase 2.986e-13 0.29
S22A6_MOUSE Slc22a6 Solute carrier family 22 member 6 4.869e-13 0.39
IL8_HUMAN CXCL8 Interleukin-8 3.783e-11 0.39
PGH1_HUMAN PTGS1 Prostaglandin G/H synthase 1 6.13e-11 0.40
PGH2_HUMAN PTGS2 Prostaglandin G/H synthase 2 2.081e-09 0.47
ALBU_BOVIN ALB Serum albumin 1.579e-08 0.39
PPOC_ORYSJ PPOX1 Protoporphyrinogen oxidase, chloroplastic 1.607e-08 0.28
PGH2_BOVIN PTGS2 Prostaglandin G/H synthase 2 3.204e-08 0.39
APAF_HUMAN APAF1 Apoptotic protease-activating factor 1 8.227e-08 0.32
PSA_HUMAN NPEPPS Puromycin-sensitive aminopeptidase 2.163e-07 0.30
CTRA_BOVIN Chymotrypsinogen A 2.472e-07 0.33
CATG_HUMAN CTSG Cathepsin G 2.721e-07 0.33
LPXC_ECOLI lpxC UDP-3-O-acyl-N-acetylglucosamine deacetylase 5.83e-07 0.33
GRM1_HUMAN GRM1 Metabotropic glutamate receptor 1 2.545e-06 0.49
PGH1_BOVIN PTGS1 Prostaglandin G/H synthase 1 5.737e-06 0.39
BLA2_BACCE blm Metallo-beta-lactamase type 2 7.112e-06 0.29
PGH2_SHEEP PTGS2 Prostaglandin G/H synthase 2 9.313e-06 0.39

Levomilnacipran

SC6A2_HUMAN SLC6A2 Sodium-dependent noradrenaline transporter 4.79e-40 1.00
SC6A4_HUMAN SLC6A4 Sodium-dependent serotonin transporter 3.119e-30 1.00
Q63380_RAT NET Transporter 1.586e-17 1.00
SC6A4_RAT Slc6a4 Sodium-dependent serotonin transporter 2.355e-11 1.00
SC6A3_HUMAN SLC6A3 Sodium-dependent dopamine transporter 9.97e-10 1.00
AMYP_RAT Amy2 Pancreatic alpha-amylase 3.167e-25 0.28
NK3R_HUMAN TACR3 Neuromedin-K receptor 6.581e-25 0.36
SC6A4_MOUSE Slc6a4 Sodium-dependent serotonin transporter 1.11e-16 0.35
OPRX_HUMAN OPRL1 Nociceptin receptor 4.441e-16 0.37
SGMR1_CAVPO SIGMAR1 Sigma non-opioid intracellular receptor 1 1.443e-15 0.38
Q9WTR4_RAT Slc6a2 Transporter 2.931e-14 0.76
SC6A2_MOUSE Slc6a2 Sodium-dependent noradrenaline transporter 3.719e-13 0.35
O77773_PIG Voltage-dependent calcium channel alpha-2 delta subunit 7.701e-11 0.30
OPRM_HUMAN OPRM1 Mu-type opioid receptor 1.093e-10 0.37
SC6A3_RAT Slc6a3 Sodium-dependent dopamine transporter 1.536e-09 0.76
SGMR1_RAT Sigmar1 Sigma non-opioid intracellular receptor 1 1.572e-08 0.35
Q17SB2_PLAFA Plasmepsin 4 2.596e-08 0.33
Q8VH26_CAVPO GPM3 Muscarinic acetylcholine receptor 1.59e-07 0.37
Q95214_RABIT ACAT Acyl-CoA:cholesterol acyltransferase 2.887e-07 0.32
OPRD_HUMAN OPRD1 Delta-type opioid receptor 6.434e-07 0.33
TSPO_HUMAN TSPO Translocator protein 1.256e-06 0.31
TSPO_RAT Tspo Translocator protein 1.401e-06 0.32
CHLE_MOUSE Bche Cholinesterase 5.79e-06 0.31
Q8I6Z5_PLAF7 Plasmepsin V 9.1e-06 0.33

Fluticasone_furoate

GCR_HUMAN NR3C1 Glucocorticoid receptor 1.422e-36 1.00
MCR_HUMAN NR3C2 Mineralocorticoid receptor 2.468e-05 1.00
ANDR_RAT Ar Androgen receptor 0.0002429 1.00
PRGR_HUMAN PGR Progesterone receptor 0.00198 1.00
ATTY_RAT Tat Tyrosine aminotransferase 1.881e-112 0.42
GCR_RAT Nr3c1 Glucocorticoid receptor 2.874e-74 0.75
Q690N0_BOVIN PGR Progesterone receptor 6.52e-43 0.59
MDR1_HUMAN ABCB1 ATP-dependent translocase ABCB1 6.343e-08 0.33
MMP1_HUMAN MMP1 Interstitial collagenase 7.093e-06 0.43
GCR_MOUSE Nr3c1 Glucocorticoid receptor 7.225e-06 0.31

Indalpine

SC6A4_RAT Slc6a4 Sodium-dependent serotonin transporter 7.427e-23 1.00
Q9WTR4_RAT Slc6a2 Transporter 2.085e-17 1.00
SC6A4_HUMAN SLC6A4 Sodium-dependent serotonin transporter 4.441e-16 1.00
MSHR_MOUSE Mc1r Melanocyte-stimulating hormone receptor 7.203e-82 0.41
EDNRA_PIG EDNRA Endothelin-1 receptor 8.128e-57 0.33
5HT1D_HUMAN HTR1D 5-hydroxytryptamine receptor 1D 2.876e-49 0.53
5HT1B_HUMAN HTR1B 5-hydroxytryptamine receptor 1B 5.634e-49 0.53
NMBR_HUMAN NMBR Neuromedin-B receptor 1.258e-47 0.33
GASR_MOUSE Cckbr Gastrin/cholecystokinin type B receptor 3.568e-46 0.38
SSR4_HUMAN SSTR4 Somatostatin receptor type 4 7.329e-42 0.42
SSR3_HUMAN SSTR3 Somatostatin receptor type 3 1.59e-37 0.38
PERM_HUMAN MPO Myeloperoxidase 5.947e-37 0.53
ECE1_HUMAN ECE1 Endothelin-converting enzyme 1 1.357e-36 0.33
DNMT1_MOUSE Dnmt1 DNA (cytosine-5)-methyltransferase 1 4.798e-35 0.36
NEP_RABIT MME Neprilysin 5.146e-33 0.33
SSR2_HUMAN SSTR2 Somatostatin receptor type 2 4.064e-32 0.42
LOX15_RABIT ALOX15 Arachidonate 15-lipoxygenase 1.323e-29 0.38
GHSR_HUMAN GHSR Growth hormone secretagogue receptor type 1 3.978e-28 0.41
CCKAR_RAT Cckar Cholecystokinin receptor type A 6.101e-26 0.38
ACE_RAT Ace Angiotensin-converting enzyme 8.011e-26 0.33
CP125_MYCTU cyp125 Steroid C26-monooxygenase 1.908e-25 0.31
ACHA7_MOUSE Chrna7 Neuronal acetylcholine receptor subunit alpha-7 8.71e-25 0.33
SSR1_HUMAN SSTR1 Somatostatin receptor type 1 1.376e-24 0.36
MC5R_HUMAN MC5R Melanocortin receptor 5 3.315e-24 0.38
NK2R_MESAU TACR2 Substance-K receptor 4.619e-23 0.37
NK2R_HUMAN TACR2 Substance-K receptor 6.138e-23 0.38
CP51_TRYCC CYP51 Sterol 14-alpha demethylase 9.358e-23 0.32
NMT_PLAF7 Glycylpeptide N-tetradecanoyltransferase 9.202e-22 0.32
5HT1E_HUMAN HTR1E 5-hydroxytryptamine receptor 1E 2.598e-21 0.47
T23O_RAT Tdo2 Tryptophan 2,3-dioxygenase 1.453e-20 0.29
ADA1B_RAT Adra1b Alpha-1B adrenergic receptor 4.375e-20 0.53
SSR5_HUMAN SSTR5 Somatostatin receptor type 5 6.46e-20 0.35
ECE1_RAT Ece1 Endothelin-converting enzyme 1 9.807e-20 0.31
MC4R_HUMAN MC4R Melanocortin receptor 4 3.224e-19 0.43
ECE1_BOVIN ECE1 Endothelin-converting enzyme 1 8.29e-19 0.30
S15A2_RAT Slc15a2 Solute carrier family 15 member 2 1.028e-18 0.33
SSR5_RAT Sstr5 Somatostatin receptor type 5 1.006e-17 0.28
NCOR2_HUMAN NCOR2 Nuclear receptor corepressor 2 3.121e-17 0.33
NK1R_HUMAN TACR1 Substance-P receptor 4.441e-16 0.47
5HT1A_HUMAN HTR1A 5-hydroxytryptamine receptor 1A 6.661e-16 0.49
THER_BACTH npr Thermolysin 9.992e-16 0.30
HES1_MOUSE Hes1 Transcription factor HES-1 4.441e-15 0.29
SIA4A_HUMAN ST3GAL1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 7.438e-15 0.28
GPR84_HUMAN GPR84 G-protein coupled receptor 84 1.077e-13 0.50
MC3R_HUMAN MC3R Melanocortin receptor 3 2.19e-13 0.39
BODG_PSESK Gamma-butyrobetaine dioxygenase 6.108e-13 0.28
ELAS_PSEAE lasB Elastase 8.983e-13 0.28
DRD4_HUMAN DRD4 D(4) dopamine receptor 1.509e-12 0.46
RAD51_HUMAN RAD51 DNA repair protein RAD51 homolog 1 1.924e-12 0.34
NK2R_RABIT TACR2 Substance-K receptor 3.017e-12 0.35
Q6Q253_PIG 5-HT4R 5-hydroxytryptamine receptor 4 protein 3.85e-12 0.33
KPYK_STAAR pyk Pyruvate kinase 4.096e-12 0.47
VMAT2_RAT Slc18a2 Synaptic vesicular amine transporter 6.982e-12 0.57
NEP_PIG MME Neprilysin 7.879e-11 0.32
BRS3_HUMAN BRS3 Bombesin receptor subtype-3 8.573e-11 0.33
CEL_HUMAN CEL Bile salt-activated lipase 1.105e-10 0.29
DRD2_HUMAN DRD2 D(2) dopamine receptor 1.166e-10 0.49
MTSI_SPISQ sssIM CPG DNA methylase 1.441e-10 0.33
DRD3_HUMAN DRD3 D(3) dopamine receptor 1.974e-10 0.47
ADA1A_RAT Adra1a Alpha-1A adrenergic receptor 3.049e-10 0.53
5HT1D_PIG HTR1D 5-hydroxytryptamine receptor 1D 3.619e-10 0.30
NK3R_CAVPO TACR3 Neuromedin-K receptor 3.816e-10 0.38
ERM_STREE erm rRNA adenine N-6-methyltransferase 4.95e-10 0.32
NK2R_RAT Tacr2 Substance-K receptor 5.523e-10 0.31
5HT5A_HUMAN HTR5A 5-hydroxytryptamine receptor 5A 9.564e-10 0.47
5HT2A_HUMAN HTR2A 5-hydroxytryptamine receptor 2A 1.118e-09 0.53
AHR_HUMAN AHR Aryl hydrocarbon receptor 1.423e-09 0.39
5HT1B_RAT Htr1b 5-hydroxytryptamine receptor 1B 1.766e-09 0.42
ACE_HUMAN ACE Angiotensin-converting enzyme 2.355e-09 0.33
CHLE_HUMAN BCHE Cholinesterase 3.378e-09 0.44
MMP8_RAT Mmp8 Neutrophil collagenase 3.598e-09 0.29
SC6A3_RAT Slc6a3 Sodium-dependent dopamine transporter 5.712e-09 0.84
DRD2_RAT Drd2 D(2) dopamine receptor 6.121e-09 0.45
5HT7R_CAVPO HTR7 5-hydroxytryptamine receptor 7 7.778e-09 0.29
SPRE_HUMAN SPR Sepiapterin reductase 1.006e-08 0.33
5HT2C_HUMAN HTR2C 5-hydroxytryptamine receptor 2C 1.943e-08 0.53
A0A286XTF2_CAVPO OPRD1 G_PROTEIN_RECEP_F1_2 domain-containing protein 2.532e-08 0.34
VMAT2_HUMAN SLC18A2 Synaptic vesicular amine transporter 4.633e-08 0.30
5HT4R_HUMAN HTR4 5-hydroxytryptamine receptor 4 5.825e-08 0.34
5HT3A_CAVPO HTR3A 5-hydroxytryptamine receptor 3A 6.571e-08 0.33
5HT6R_HUMAN HTR6 5-hydroxytryptamine receptor 6 1.013e-07 0.53
Q9BJF5_TOXGO CDPK1 Calmodulin-domain protein kinase 1 1.124e-07 0.33
ACES_HUMAN ACHE Acetylcholinesterase 1.847e-07 0.44
GCR_HUMAN NR3C1 Glucocorticoid receptor 2.151e-07 0.33
5HT5A_MOUSE Htr5a 5-hydroxytryptamine receptor 5A 2.267e-07 0.28
TRPM8_RAT Trpm8 Transient receptor potential cation channel subfamily M member 8 2.296e-07 0.44
HDAC3_HUMAN HDAC3 Histone deacetylase 3 2.626e-07 0.36
5HT1A_RAT Htr1a 5-hydroxytryptamine receptor 1A 3.777e-07 0.53
5HT4R_CAVPO HTR4 5-hydroxytryptamine receptor 4 4.002e-07 0.35
GYRB_MYCS2 gyrB DNA gyrase subunit B 4.359e-07 0.30
C11B1_RAT Cyp11b1 Cytochrome P450 11B1, mitochondrial 7.484e-07 0.38
PAK4_HUMAN PAK4 Serine/threonine-protein kinase PAK 4 8.057e-07 0.30
SC6A2_HUMAN SLC6A2 Sodium-dependent noradrenaline transporter 1.206e-06 0.47
MCR_HUMAN NR3C2 Mineralocorticoid receptor 1.297e-06 0.33
MMP9_HUMAN MMP9 Matrix metalloproteinase-9 1.68e-06 0.42
HDAC1_HUMAN HDAC1 Histone deacetylase 1 1.739e-06 0.36
MRP2_RAT Abcc2 Canalicular multispecific organic anion transporter 1 1.858e-06 0.28
TYTR_TRYCR TPR Trypanothione reductase 2.052e-06 0.38
T23O_MOUSE Tdo2 Tryptophan 2,3-dioxygenase 3.933e-06 0.30
5HT2B_HUMAN HTR2B 5-hydroxytryptamine receptor 2B 4.003e-06 0.47
5HT2B_RAT Htr2b 5-hydroxytryptamine receptor 2B 5.15e-06 0.53
5HT2A_RAT Htr2a 5-hydroxytryptamine receptor 2A 5.418e-06 0.47
CCKAR_CAVPO CCKAR Cholecystokinin receptor type A 5.681e-06 0.31
5HT2C_RAT Htr2c 5-hydroxytryptamine receptor 2C 5.683e-06 0.47
HDAC2_HUMAN HDAC2 Histone deacetylase 2 8.387e-06 0.36
HDA11_HUMAN HDAC11 Histone deacetylase 11 8.629e-06 0.33

Dabrafenib

BRAF_HUMAN BRAF Serine/threonine-protein kinase B-raf 1.018e-20 1.00
RASK_HUMAN KRAS GTPase KRas 8.882e-16 1.00
ARAF_HUMAN ARAF Serine/threonine-protein kinase A-Raf 4.15e-13 1.00
RAF1_HUMAN RAF1 RAF proto-oncogene serine/threonine-protein kinase 5.869e-05 1.00
TGFR1_HUMAN TGFBR1 TGF-beta receptor type-1 0.004653 1.00
GCKR_RAT Gckr Glucokinase regulatory protein 8.224e-23 0.29
S40A1_HUMAN SLC40A1 Solute carrier family 40 member 1 3.331e-16 0.41
GCKR_MOUSE Gckr Glucokinase regulatory protein 2.515e-12 0.29
AL5AP_HUMAN ALOX5AP Arachidonate 5-lipoxygenase-activating protein 3.841e-12 0.34
PI4KA_HUMAN PI4KA Phosphatidylinositol 4-kinase alpha 3.116e-09 0.30
IKBA_HUMAN NFKBIA NF-kappa-B inhibitor alpha 1.757e-08 0.30
GCKR_HUMAN GCKR Glucokinase regulatory protein 1.853e-08 0.29
AVR2B_HUMAN ACVR2B Activin receptor type-2B 7.481e-08 0.37
CCNH_HUMAN CCNH Cyclin-H 4.128e-07 0.31
CCR9_HUMAN CCR9 C-C chemokine receptor type 9 1.793e-06 0.31
ROCK1_HUMAN ROCK1 Rho-associated protein kinase 1 2.861e-06 0.33

Chlorcyclizine

CP2D6_HUMAN CYP2D6 Cytochrome P450 2D6 5.399e-19 1.00
CAC1B_RAT Cacna1b Voltage-dependent N-type calcium channel subunit alpha-1B 1.612e-103 0.57
CA2D2_RAT Cacna2d2 Voltage-dependent calcium channel subunit alpha-2/delta-2 2.338e-90 0.57
CACB1_HUMAN CACNB1 Voltage-dependent L-type calcium channel subunit beta-1 2.338e-90 0.57
CACB1_RAT Cacnb1 Voltage-dependent L-type calcium channel subunit beta-1 1.844e-88 0.57
CAC1A_HUMAN CACNA1A Voltage-dependent P/Q-type calcium channel subunit alpha-1A 9.13e-82 0.57
CA2D1_RAT Cacna2d1 Voltage-dependent calcium channel subunit alpha-2/delta-1 8.116e-59 0.51
NMUR1_HUMAN NMUR1 Neuromedin-U receptor 1 3.139e-49 0.41
OPRX_HUMAN OPRL1 Nociceptin receptor 1.326e-46 0.57
NMUR2_HUMAN NMUR2 Neuromedin-U receptor 2 1.24e-45 0.41
TYRP1_MOUSE Tyrp1 5,6-dihydroxyindole-2-carboxylic acid oxidase 3.841e-36 0.30
Q9MYJ9_RABIT CCR1 Chemokine receptor 1.609e-35 0.28
HRH4_HUMAN HRH4 Histamine H4 receptor 2.612e-34 0.40
CP19A_RAT Cyp19a1 Aromatase 1.32e-33 0.54
SC6A3_RAT Slc6a3 Sodium-dependent dopamine transporter 3.771e-27 0.54
US28_HCMVA US28 G-protein coupled receptor homolog US28 3.064e-25 0.37
OPRD_HUMAN OPRD1 Delta-type opioid receptor 5.742e-24 0.57
CAC1G_HUMAN CACNA1G Voltage-dependent T-type calcium channel subunit alpha-1G 1.539e-23 0.57
OPRM_HUMAN OPRM1 Mu-type opioid receptor 2.89e-21 0.57
OPRK_HUMAN OPRK1 Kappa-type opioid receptor 1.835e-20 0.57
Q91ZY3_CAVPO HRH4 Histamine H4 receptor 1.523e-18 0.29
SC6A4_RAT Slc6a4 Sodium-dependent serotonin transporter 1.616e-18 0.42
GP139_HUMAN GPR139 Probable G-protein coupled receptor 139 2.133e-18 0.33
5HT3B_HUMAN HTR3B 5-hydroxytryptamine receptor 3B 3.175e-18 0.35
MC4R_HUMAN MC4R Melanocortin receptor 4 1.272e-17 0.56
MGLL_MOUSE Mgll Monoglyceride lipase 1.48e-17 0.43
DRD5_HUMAN DRD5 D(1B) dopamine receptor 1.706e-17 0.32
DRD1_HUMAN DRD1 D(1A) dopamine receptor 2.514e-17 0.38
Q9WTR4_RAT Slc6a2 Transporter 1.11e-16 0.42
Q8HY88_BOVIN KCNK2 Potassium channel subfamily K member 2 3.775e-15 0.38
HRH4_RAT Hrh4 Histamine H4 receptor 4.33e-15 0.33
DRD1_RAT Drd1 D(1A) dopamine receptor 5.773e-15 0.40
5HT3A_HUMAN HTR3A 5-hydroxytryptamine receptor 3A 9.881e-15 0.35
PCP_MOUSE Prcp Lysosomal Pro-X carboxypeptidase 4.43e-14 0.36
DRD2_HUMAN DRD2 D(2) dopamine receptor 2.318e-13 0.57
HRH1_HUMAN HRH1 Histamine H1 receptor 4.583e-13 0.79
SHIP2_HUMAN INPPL1 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 6.861e-13 0.32
5HT2A_RAT Htr2a 5-hydroxytryptamine receptor 2A 7.055e-13 0.48
CNR1_RAT Cnr1 Cannabinoid receptor 1 9.766e-13 0.46
DRD4_HUMAN DRD4 D(4) dopamine receptor 1.088e-12 0.42
5HT2C_RAT Htr2c 5-hydroxytryptamine receptor 2C 1.664e-12 0.48
B2LA1_HUMAN BCL2A1 Bcl-2-related protein A1 1.808e-12 0.33
PA24A_HUMAN PLA2G4A Cytosolic phospholipase A2 3.195e-12 0.30
MGLL_RAT Mgll Monoglyceride lipase 4.313e-12 0.38
CA2D1_HUMAN CACNA2D1 Voltage-dependent calcium channel subunit alpha-2/delta-1 5.776e-12 0.57
SC6A2_HUMAN SLC6A2 Sodium-dependent noradrenaline transporter 6.348e-12 0.42
CNR1_HUMAN CNR1 Cannabinoid receptor 1 9.391e-12 0.44
HRH4_MOUSE Hrh4 Histamine H4 receptor 1.422e-11 0.29
DRD3_HUMAN DRD3 D(3) dopamine receptor 1.426e-11 0.79
5HT3B_RAT Htr3b 5-hydroxytryptamine receptor 3B 3.079e-11 0.32
ADA1B_RAT Adra1b Alpha-1B adrenergic receptor 3.441e-11 0.79
CALM_BOVIN CALM Calmodulin 6.343e-11 0.29
PCP_HUMAN PRCP Lysosomal Pro-X carboxypeptidase 7.256e-11 0.36
B2LA1_MOUSE Bcl2a1 Bcl-2-related protein A1 8.999e-11 0.33
SC6A3_HUMAN SLC6A3 Sodium-dependent dopamine transporter 1.235e-10 0.79
O31048_PORGN DPP IV Dipeptidyl peptidase IV 2.713e-10 0.49
LUXR_ALIFS luxR Transcriptional activator protein LuxR 2.895e-10 0.29
RCE1_YEAST RCE1 CAAX prenyl protease 2 4.239e-10 0.43
ACHA9_RAT Chrna9 Neuronal acetylcholine receptor subunit alpha-9 1.863e-09 0.30
SETD7_HUMAN SETD7 Histone-lysine N-methyltransferase SETD7 1.863e-09 0.30
INHA_MYCTU inhA Enoyl-[acyl-carrier-protein] reductase [NADH] 2.75e-09 0.43
MGLL_HUMAN MGLL Monoglyceride lipase 3.416e-09 0.38
ACM1_RAT Chrm1 Muscarinic acetylcholine receptor M1 5.713e-09 0.42
SCN2A_RAT Scn2a Sodium channel protein type 2 subunit alpha 6.663e-09 0.38
ACM1_HUMAN CHRM1 Muscarinic acetylcholine receptor M1 1.154e-08 0.79
5HT3A_RAT Htr3a 5-hydroxytryptamine receptor 3A 1.288e-08 0.32
SC6A4_HUMAN SLC6A4 Sodium-dependent serotonin transporter 4.292e-08 0.42
S6A13_MOUSE Slc6a13 Sodium- and chloride-dependent GABA transporter 2 4.633e-08 0.30
SGMR1_HUMAN SIGMAR1 Sigma non-opioid intracellular receptor 1 5.177e-08 0.42
ACM5_RAT Chrm5 Muscarinic acetylcholine receptor M5 9.621e-08 0.36
EBP_CAVPO EBP 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase 1.447e-07 0.31
ADA2A_HUMAN ADRA2A Alpha-2A adrenergic receptor 1.573e-07 0.79
SCN4A_HUMAN SCN4A Sodium channel protein type 4 subunit alpha 1.594e-07 0.33
DRD4_RAT Drd4 D(4) dopamine receptor 2.211e-07 0.31
PDR5_YEAST PDR5 Pleiotropic ABC efflux transporter of multiple drugs 2.488e-07 0.33
LSS_HUMAN LSS Lanosterol synthase 2.557e-07 0.32
AOFA_RAT Maoa Amine oxidase [flavin-containing] A 3.297e-07 0.41
DRD2_RAT Drd2 D(2) dopamine receptor 1.063e-06 0.40
HCN1_HUMAN HCN1 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 1.239e-06 0.34
CEGT_HUMAN UGCG Ceramide glucosyltransferase 1.324e-06 0.30
5HT2B_HUMAN HTR2B 5-hydroxytryptamine receptor 2B 1.595e-06 0.79
5HT2A_PIG HTR2A 5-hydroxytryptamine receptor 2A 2.073e-06 0.32
HRH1_CAVPO HRH1 Histamine H1 receptor 2.266e-06 0.37
S6A12_MOUSE Slc6a12 Sodium- and chloride-dependent betaine transporter 2.488e-06 0.30
ACHP_LYMST Acetylcholine-binding protein 2.972e-06 0.33
HRH1_RAT Hrh1 Histamine H1 receptor 2.986e-06 0.33
CCR5_HUMAN CCR5 C-C chemokine receptor type 5 3.784e-06 0.36
OPRD_RAT Oprd1 Delta-type opioid receptor 4.026e-06 0.55
5HT2A_HUMAN HTR2A 5-hydroxytryptamine receptor 2A 5.998e-06 0.79
5HT6R_HUMAN HTR6 5-hydroxytryptamine receptor 6 6.059e-06 0.37
CP51A_HUMAN CYP51A1 Lanosterol 14-alpha demethylase 6.235e-06 0.29
LOX5_HUMAN ALOX5 Arachidonate 5-lipoxygenase 8.739e-06 0.44

Indoramin

ADA2A_HUMAN ADRA2A Alpha-2A adrenergic receptor 3.997e-15 1.00
ADA2B_HUMAN ADRA2B Alpha-2B adrenergic receptor 3.192e-13 1.00
ADA2C_HUMAN ADRA2C Alpha-2C adrenergic receptor 3.047e-07 1.00
ADA1D_RAT Adra1d Alpha-1D adrenergic receptor 5.789e-07 1.00
ADA1D_HUMAN ADRA1D Alpha-1D adrenergic receptor 1.133e-06 1.00
ADA1A_BOVIN ADRA1A Alpha-1A adrenergic receptor 1.525e-06 1.00
ADA1A_HUMAN ADRA1A Alpha-1A adrenergic receptor 6.893e-06 1.00
ADA1B_HUMAN ADRA1B Alpha-1B adrenergic receptor 3.583e-05 1.00
5HT1B_HUMAN HTR1B 5-hydroxytryptamine receptor 1B 8.855e-139 0.54
5HT1D_HUMAN HTR1D 5-hydroxytryptamine receptor 1D 1.318e-137 0.51
MSHR_MOUSE Mc1r Melanocyte-stimulating hormone receptor 6.595e-118 0.47
SYUA_HUMAN SNCA Alpha-synuclein 1.837e-115 0.39
PLD1_RAT Pld1 Phospholipase D1 1.306e-108 0.38
SSR2_HUMAN SSTR2 Somatostatin receptor type 2 1.254e-100 0.48
EDNRA_PIG EDNRA Endothelin-1 receptor 1.333e-97 0.36
CP51_TRYCC CYP51 Sterol 14-alpha demethylase 1.211e-96 0.40
NK2R_RAT Tacr2 Substance-K receptor 1.521e-88 0.74
MK03_MOUSE Mapk3 Mitogen-activated protein kinase 3 1.451e-87 0.36
GASR_MOUSE Cckbr Gastrin/cholecystokinin type B receptor 2.054e-85 0.44
PLD2_HUMAN PLD2 Phospholipase D2 3.928e-76 0.43
NMBR_HUMAN NMBR Neuromedin-B receptor 4.046e-76 0.40
SSR4_HUMAN SSTR4 Somatostatin receptor type 4 2.19e-73 0.48
CCKAR_RAT Cckar Cholecystokinin receptor type A 3.097e-73 0.41
NK2R_RABIT TACR2 Substance-K receptor 5.006e-72 0.34
DRD3_HUMAN DRD3 D(3) dopamine receptor 1.419e-71 0.51
DRD2_HUMAN DRD2 D(2) dopamine receptor 2.257e-71 0.51
PLD1_HUMAN PLD1 Phospholipase D1 6.011e-69 0.38
5HT4R_HUMAN HTR4 5-hydroxytryptamine receptor 4 5.209e-66 0.51
5HT2A_HUMAN HTR2A 5-hydroxytryptamine receptor 2A 1.42e-65 0.54
GHSR_HUMAN GHSR Growth hormone secretagogue receptor type 1 2.79e-65 0.38
ECE1_BOVIN ECE1 Endothelin-converting enzyme 1 1.861e-63 0.37
ECE1_HUMAN ECE1 Endothelin-converting enzyme 1 1.654e-62 0.39
NK2R_HUMAN TACR2 Substance-K receptor 4.061e-62 0.43
SSR1_HUMAN SSTR1 Somatostatin receptor type 1 1.016e-61 0.48
MK01_MOUSE Mapk1 Mitogen-activated protein kinase 1 1.419e-61 0.39
SSR3_HUMAN SSTR3 Somatostatin receptor type 3 1.935e-60 0.55
SSR5_HUMAN SSTR5 Somatostatin receptor type 5 3.727e-60 0.49
EDNRB_RAT Ednrb Endothelin receptor type B 5.396e-60 0.35
SPRE_HUMAN SPR Sepiapterin reductase 1.271e-55 0.39
MMP11_MOUSE Mmp11 Stromelysin-3 1.226e-54 0.31
NK1R_HUMAN TACR1 Substance-P receptor 3.104e-54 0.45
ANM6_HUMAN PRMT6 Protein arginine N-methyltransferase 6 2.195e-53 0.58
DRD4_HUMAN DRD4 D(4) dopamine receptor 2.041e-51 0.52
MC5R_MOUSE Mc5r Melanocortin receptor 5 6.605e-51 0.47
GASR_RAT Cckbr Gastrin/cholecystokinin type B receptor 1.313e-48 0.34
CCR2_HUMAN CCR2 C-C chemokine receptor type 2 6.348e-48 0.51
SSR2_MOUSE Sstr2 Somatostatin receptor type 2 1.091e-46 0.33
MC3R_HUMAN MC3R Melanocortin receptor 3 1.731e-46 0.43
NK2R_MESAU TACR2 Substance-K receptor 3.121e-46 0.44
NCOR2_HUMAN NCOR2 Nuclear receptor corepressor 2 3.702e-45 0.34
PAQR1_HUMAN ADIPOR1 Adiponectin receptor protein 1 4.407e-45 0.36
PAQR2_HUMAN ADIPOR2 Adiponectin receptor protein 2 4.407e-45 0.36
CASR_MOUSE Casr Extracellular calcium-sensing receptor 1.289e-44 0.35
NEP_RABIT MME Neprilysin 4.694e-44 0.37
5HT1A_HUMAN HTR1A 5-hydroxytryptamine receptor 1A 7.77e-43 0.54
CCKAR_MOUSE Cckar Cholecystokinin receptor type A 9.83e-43 0.34
SGMR1_HUMAN SIGMAR1 Sigma non-opioid intracellular receptor 1 9.855e-43 0.61
5HT1A_RAT Htr1a 5-hydroxytryptamine receptor 1A 1.006e-42 0.55
CARM1_HUMAN CARM1 Histone-arginine methyltransferase CARM1 1.212e-42 0.58
CP2J2_HUMAN CYP2J2 Cytochrome P450 2J2 2.482e-42 0.30
GRPR_RAT Grpr Gastrin-releasing peptide receptor 3.987e-42 0.31
GHSR_RAT Ghsr Growth hormone secretagogue receptor type 1 2.825e-41 0.34
MC4R_MOUSE Mc4r Melanocortin receptor 4 4.826e-41 0.47
MC5R_HUMAN MC5R Melanocortin receptor 5 5.051e-41 0.43
MC4R_HUMAN MC4R Melanocortin receptor 4 1.23e-40 0.48
DRD2_RAT Drd2 D(2) dopamine receptor 1.46e-40 0.55
UR2R_HUMAN UTS2R Urotensin-2 receptor 2.882e-40 0.40
ACHA7_MACMU CHRNA7 Neuronal acetylcholine receptor subunit alpha-7 3.824e-40 0.32
RIR1_MYCTU nrdE Ribonucleoside-diphosphate reductase subunit alpha 1.942e-39 0.33
RUVB1_HUMAN RUVBL1 RuvB-like 1 2.419e-39 0.31
5HT2A_RAT Htr2a 5-hydroxytryptamine receptor 2A 4.956e-38 0.55
HPGDS_HUMAN HPGDS Hematopoietic prostaglandin D synthase 8.827e-38 0.40
SC6A4_RAT Slc6a4 Sodium-dependent serotonin transporter 1.029e-37 0.51
UR2R_MACMU UTS2R Urotensin-2 receptor 8.297e-37 0.29
DRD2_MOUSE Drd2 D(2) dopamine receptor 1.054e-36 0.59
NTR1_MOUSE Ntsr1 Neurotensin receptor type 1 1.496e-36 0.31
DNMT1_MOUSE Dnmt1 DNA (cytosine-5)-methyltransferase 1 2.21e-36 0.38
SC6A5_HUMAN SLC6A5 Sodium- and chloride-dependent glycine transporter 2 3.909e-36 0.40
IL1RA_MOUSE Il1rn Interleukin-1 receptor antagonist protein 6.145e-36 0.28
CCKAR_CAVPO CCKAR Cholecystokinin receptor type A 1.659e-35 0.42
ACE_RAT Ace Angiotensin-converting enzyme 1.76e-35 0.37
KISSR_HUMAN KISS1R KiSS-1 receptor 2.168e-35 0.33
BRS3_HUMAN BRS3 Bombesin receptor subtype-3 2.661e-35 0.46
LOX15_RABIT ALOX15 Arachidonate 15-lipoxygenase 6.316e-35 0.39
EPHA2_MOUSE Epha2 Ephrin type-A receptor 2 8.663e-34 0.30
ADA1B_RAT Adra1b Alpha-1B adrenergic receptor 1.061e-33 0.43
ACKR3_HUMAN ACKR3 Atypical chemokine receptor 3 2.003e-33 0.40
5HT2C_RAT Htr2c 5-hydroxytryptamine receptor 2C 3.73e-33 0.42
5HT1F_HUMAN HTR1F 5-hydroxytryptamine receptor 1F 4.336e-33 0.41
CCR3_HUMAN CCR3 C-C chemokine receptor type 3 4.796e-33 0.48
NK1R_MOUSE Tacr1 Substance-P receptor 5.409e-32 0.32
GBRA1_RAT Gabra1 Gamma-aminobutyric acid receptor subunit alpha-1 6.019e-32 0.34
MCHR1_HUMAN MCHR1 Melanin-concentrating hormone receptor 1 1.229e-31 0.49
GBRB2_RAT Gabrb2 Gamma-aminobutyric acid receptor subunit beta-2 2.354e-31 0.34
NK2R_BOVIN TACR2 Substance-K receptor 3.475e-31 0.31
MMP11_HUMAN MMP11 Stromelysin-3 3.648e-31 0.31
CHLE_HUMAN BCHE Cholinesterase 6.232e-31 0.62
ECE1_RAT Ece1 Endothelin-converting enzyme 1 7.281e-31 0.35
AOC3_MOUSE Aoc3 Membrane primary amine oxidase 2.225e-30 0.30
GHRHR_RAT Ghrhr Growth hormone-releasing hormone receptor 3.984e-30 0.33
NMD3A_RAT Grin3a Glutamate receptor ionotropic, NMDA 3A 1.836e-29 0.32
GBRG2_RAT Gabrg2 Gamma-aminobutyric acid receptor subunit gamma-2 5.334e-29 0.34
ACES_MOUSE Ache Acetylcholinesterase 1.353e-28 0.38
DSBA_ECOLI dsbA Thiol:disulfide interchange protein DsbA 1.816e-28 0.30
C5AR1_HUMAN C5AR1 C5a anaphylatoxin chemotactic receptor 1 2.188e-28 0.32
GBRA2_RAT Gabra2 Gamma-aminobutyric acid receptor subunit alpha-2 3.923e-28 0.34
ACES_HUMAN ACHE Acetylcholinesterase 9.02e-27 0.62
5HT3B_MOUSE Htr3b 5-hydroxytryptamine receptor 3B 9.89e-27 0.36
CP125_MYCTU cyp125 Steroid C26-monooxygenase 1.158e-26 0.33
JUN_HUMAN JUN Transcription factor AP-1 1.409e-26 0.37
MSHR_HUMAN MC1R Melanocyte-stimulating hormone receptor 2.848e-26 0.43
DRD3_RAT Drd3 D(3) dopamine receptor 3.941e-26 0.38
NMDE2_RAT Grin2b Glutamate receptor ionotropic, NMDA 2B 6.053e-26 0.47
OPRM_RAT Oprm1 Mu-type opioid receptor 7.014e-26 0.41
HRH1_CAVPO HRH1 Histamine H1 receptor 7.525e-26 0.43
5HT7R_HUMAN HTR7 5-hydroxytryptamine receptor 7 1.495e-25 0.47
Q5NGQ3_FRATT fabI Enoyl-[acyl-carrier-protein] reductase [NADH] 1.532e-25 0.33
5HT1D_RAT Htr1d 5-hydroxytryptamine receptor 1D 5.512e-25 0.39
ACHA7_MOUSE Chrna7 Neuronal acetylcholine receptor subunit alpha-7 5.783e-25 0.34
MMP9_HUMAN MMP9 Matrix metalloproteinase-9 2.721e-24 0.45
HDAC3_HUMAN HDAC3 Histone deacetylase 3 2.833e-24 0.44
MC3R_MOUSE Mc3r Melanocortin receptor 3 4.302e-24 0.47
NMBR_RAT Nmbr Neuromedin-B receptor 4.904e-24 0.30
EDNRA_HUMAN EDNRA Endothelin-1 receptor 6.4e-24 0.35
5HT4R_RAT Htr4 5-hydroxytryptamine receptor 4 8.606e-24 0.43
HDAC2_HUMAN HDAC2 Histone deacetylase 2 1.291e-23 0.44
ADA2A_PIG ADRA2A Alpha-2A adrenergic receptor 1.444e-23 0.29
ADA1A_RAT Adra1a Alpha-1A adrenergic receptor 1.885e-23 0.43
THER_BACTH npr Thermolysin 3.024e-23 0.37
KPCB_MOUSE Prkcb Protein kinase C beta type 4.035e-23 0.28
GBRA5_RAT Gabra5 Gamma-aminobutyric acid receptor subunit alpha-5 4.353e-23 0.34
5HT1D_PIG HTR1D 5-hydroxytryptamine receptor 1D 8.734e-23 0.36
GBRB3_RAT Gabrb3 Gamma-aminobutyric acid receptor subunit beta-3 9.302e-23 0.34
CCR8_HUMAN CCR8 C-C chemokine receptor type 8 1.194e-22 0.38
5HT3B_RAT Htr3b 5-hydroxytryptamine receptor 3B 1.306e-22 0.38
MCHR1_MOUSE Mchr1 Melanin-concentrating hormone receptor 1 1.819e-22 0.39
LCAP_HUMAN LNPEP Leucyl-cystinyl aminopeptidase 2.163e-22 0.31
MMP8_HUMAN MMP8 Neutrophil collagenase 2.618e-22 0.39
EDNRA_MOUSE Ednra Endothelin-1 receptor 4.703e-22 0.29
5HT4R_CAVPO HTR4 5-hydroxytryptamine receptor 4 5.025e-22 0.45
SGMR1_MOUSE Sigmar1 Sigma non-opioid intracellular receptor 1 7.824e-22 0.59
ERAP2_HUMAN ERAP2 Endoplasmic reticulum aminopeptidase 2 8.106e-22 0.38
ACES_BOVIN ACHE Acetylcholinesterase 1.239e-21 0.37
ACM1_HUMAN CHRM1 Muscarinic acetylcholine receptor M1 1.643e-21 0.42
S15A2_RAT Slc15a2 Solute carrier family 15 member 2 2.242e-21 0.38
CHLE_HORSE BCHE Cholinesterase 3.071e-21 0.62
PERM_HUMAN MPO Myeloperoxidase 3.811e-21 0.42
SHH_MOUSE Shh Sonic hedgehog protein 7.133e-21 0.38
MMP2_HUMAN MMP2 72 kDa type IV collagenase 9.795e-21 0.41
GASR_HUMAN CCKBR Gastrin/cholecystokinin type B receptor 1.894e-20 0.40
HDAC1_HUMAN HDAC1 Histone deacetylase 1 2.287e-20 0.45
CASR_RAT Casr Extracellular calcium-sensing receptor 2.51e-20 0.35
EDNRA_RAT Ednra Endothelin-1 receptor 3.484e-20 0.40
Q8MI13_BOVIN 5htr1d 5-hydroxytryptamine 1D receptor 3.523e-20 0.32
5HT1A_MOUSE Htr1a 5-hydroxytryptamine receptor 1A 4.276e-20 0.38
CFTR_HUMAN CFTR Cystic fibrosis transmembrane conductance regulator 5.693e-20 0.34
GRPR_HUMAN GRPR Gastrin-releasing peptide receptor 5.933e-20 0.34
SCN2A_RAT Scn2a Sodium channel protein type 2 subunit alpha 2.019e-19 0.33
5HT1B_RAT Htr1b 5-hydroxytryptamine receptor 1B 2.046e-19 0.39
ACES_ELEEL ache Acetylcholinesterase 2.169e-19 0.62
MMP8_RAT Mmp8 Neutrophil collagenase 5.128e-19 0.32
ACM3_HUMAN CHRM3 Muscarinic acetylcholine receptor M3 5.175e-19 0.37
SSR5_RAT Sstr5 Somatostatin receptor type 5 1.064e-18 0.30
G3I1B6_CRIGR 5-hydroxytryptamine receptor 1.161e-18 0.35
LSHR_RAT Lhcgr Lutropin-choriogonadotropic hormone receptor 1.69e-18 0.30
5HT1B_CRIGR HTR1B 5-hydroxytryptamine receptor 1B 1.933e-18 0.35
AAKB2_HUMAN PRKAB2 5'-AMP-activated protein kinase subunit beta-2 2.576e-18 0.29
ELAS_PSEAE lasB Elastase 2.688e-18 0.32
GPC6A_MOUSE Gprc6a G-protein coupled receptor family C group 6 member A 3.72e-18 0.29
UR2R_RAT Uts2r Urotensin-2 receptor 4.427e-18 0.32
5HT7R_CAVPO HTR7 5-hydroxytryptamine receptor 7 7.734e-18 0.34
HES1_MOUSE Hes1 Transcription factor HES-1 1.882e-17 0.33
ERAP1_HUMAN ERAP1 Endoplasmic reticulum aminopeptidase 1 2.135e-17 0.35
NCOR1_HUMAN NCOR1 Nuclear receptor corepressor 1 2.244e-17 0.37
5HT3A_RAT Htr3a 5-hydroxytryptamine receptor 3A 2.638e-17 0.38
OPRM_HUMAN OPRM1 Mu-type opioid receptor 2.771e-17 0.53
OPRM_CAVPO OPRM1 Mu-type opioid receptor 3.809e-17 0.41
ACE_HUMAN ACE Angiotensin-converting enzyme 5.361e-17 0.38
5HT1E_HUMAN HTR1E 5-hydroxytryptamine receptor 1E 1.11e-16 0.34
DRD1_BOVIN DRD1 D(1A) dopamine receptor 1.11e-16 0.37
SIA4A_HUMAN ST3GAL1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 1.11e-16 0.32
5HT6R_HUMAN HTR6 5-hydroxytryptamine receptor 6 2.22e-16 0.46
SGMR2_RAT Tmem97 Sigma intracellular receptor 2 3.331e-16 0.36
5HT3A_CAVPO HTR3A 5-hydroxytryptamine receptor 3A 4.441e-16 0.42
ACHP_LYMST Acetylcholine-binding protein 7.772e-16 0.35
CAC1C_RAT Cacna1c Voltage-dependent L-type calcium channel subunit alpha-1C 7.772e-16 0.39
HRH2_HUMAN HRH2 Histamine H2 receptor 1.887e-15 0.36
BODG_PSESK Gamma-butyrobetaine dioxygenase 2.22e-15 0.34
HYEP_HUMAN EPHX1 Epoxide hydrolase 1 2.331e-15 0.38
5HT3B_HUMAN HTR3B 5-hydroxytryptamine receptor 3B 2.776e-15 0.29
Q9N6S8_PLAFA Cysteine proteinase falcipain 2a 2.887e-15 0.33
S6A12_HUMAN SLC6A12 Sodium- and chloride-dependent betaine transporter 3.775e-15 0.38
HYEP_MOUSE Ephx1 Epoxide hydrolase 1 5.662e-15 0.32
MCHR1_RAT Mchr1 Melanin-concentrating hormone receptor 1 7.105e-15 0.37
CCKAR_HUMAN CCKAR Cholecystokinin receptor type A 7.216e-15 0.33
ACHA7_HUMAN CHRNA7 Neuronal acetylcholine receptor subunit alpha-7 8.771e-15 0.35
Q6Q253_PIG 5-HT4R 5-hydroxytryptamine receptor 4 protein 9.77e-15 0.40
OPRD_RAT Oprd1 Delta-type opioid receptor 1.255e-14 0.36
5HT2C_HUMAN HTR2C 5-hydroxytryptamine receptor 2C 1.332e-14 0.54
MRP2_RAT Abcc2 Canalicular multispecific organic anion transporter 1 1.565e-14 0.39
FPRS1_MOUSE Fpr-s1 Formyl peptide receptor-related sequence 1 1.699e-14 0.30
RAD51_HUMAN RAD51 DNA repair protein RAD51 homolog 1 1.732e-14 0.43
KCNH2_HUMAN KCNH2 Potassium voltage-gated channel subfamily H member 2 2.365e-14 0.37
TGM2_HUMAN TGM2 Protein-glutamine gamma-glutamyltransferase 2 2.942e-14 0.35
CCR5_HUMAN CCR5 C-C chemokine receptor type 5 3.819e-14 0.38
VMAT2_MOUSE Slc18a2 Synaptic vesicular amine transporter 6.328e-14 0.34
5HT1D_CAVPO HTR1D 5-hydroxytryptamine receptor 1D 6.362e-14 0.31
C3SLN3_ECOLX gyrB DNA gyrase subunit B 6.539e-14 0.30
NK1R_CAVPO TACR1 Substance-P receptor 9.17e-14 0.36
SC6A4_HUMAN SLC6A4 Sodium-dependent serotonin transporter 1.145e-13 0.45
MMP14_HUMAN MMP14 Matrix metalloproteinase-14 1.192e-13 0.32
ADA12_HUMAN ADAM12 Disintegrin and metalloproteinase domain-containing protein 12 1.242e-13 0.30
LKHA4_HUMAN LTA4H Leukotriene A-4 hydrolase 1.388e-13 0.36
PAK4_HUMAN PAK4 Serine/threonine-protein kinase PAK 4 3.545e-13 0.32
PPIB_HUMAN PPIB Peptidyl-prolyl cis-trans isomerase B 4.938e-13 0.35
ACM2_HUMAN CHRM2 Muscarinic acetylcholine receptor M2 5.994e-13 0.39
HDA11_HUMAN HDAC11 Histone deacetylase 11 6.295e-13 0.35
HYES_MOUSE Ephx2 Bifunctional epoxide hydrolase 2 7.585e-13 0.35
HDAC8_HUMAN HDAC8 Histone deacetylase 8 1.7e-12 0.41
ERM_STREE erm rRNA adenine N-6-methyltransferase 1.895e-12 0.40
NK3R_RAT Tacr3 Neuromedin-K receptor 3.363e-12 0.33
MK09_HUMAN MAPK9 Mitogen-activated protein kinase 9 3.776e-12 0.37
5HT3A_HUMAN HTR3A 5-hydroxytryptamine receptor 3A 3.927e-12 0.34
KCC2D_HUMAN CAMK2D Calcium/calmodulin-dependent protein kinase type II subunit delta 4.099e-12 0.35
OPRD_MOUSE Oprd1 Delta-type opioid receptor 4.484e-12 0.38
Q8CGM4_CAVPO OPRM1 Mu-opioid receptor 6.206e-12 0.33
NK3R_CAVPO TACR3 Neuromedin-K receptor 7.609e-12 0.46
NRP1_RAT Nrp1 Neuropilin-1 7.616e-12 0.29
MTSI_SPISQ sssIM CPG DNA methylase 1.133e-11 0.37
ADA17_PIG ADAM17 Disintegrin and metalloproteinase domain-containing protein 17 1.61e-11 0.31
VMAT2_RAT Slc18a2 Synaptic vesicular amine transporter 1.617e-11 0.44
SGMR1_RAT Sigmar1 Sigma non-opioid intracellular receptor 1 1.627e-11 0.55
NEP_PIG MME Neprilysin 2.335e-11 0.33
V1AR_MOUSE Avpr1a Vasopressin V1a receptor 2.556e-11 0.29
CAC1G_HUMAN CACNA1G Voltage-dependent T-type calcium channel subunit alpha-1G 3.111e-11 0.34
SMYD3_HUMAN SMYD3 Histone-lysine N-methyltransferase SMYD3 5.932e-11 0.29
SGMR1_CAVPO SIGMAR1 Sigma non-opioid intracellular receptor 1 6.781e-11 0.43
SCN1A_HUMAN SCN1A Sodium channel protein type 1 subunit alpha 6.9e-11 0.42
CATL1_HUMAN CTSL Cathepsin L1 7.869e-11 0.38
MK08_HUMAN MAPK8 Mitogen-activated protein kinase 8 1.247e-10 0.37
HRH3_HUMAN HRH3 Histamine H3 receptor 1.327e-10 0.42
OPRD_HUMAN OPRD1 Delta-type opioid receptor 1.999e-10 0.53
ACHA7_RAT Chrna7 Neuronal acetylcholine receptor subunit alpha-7 2.5e-10 0.38
TYTR_TRYCR TPR Trypanothione reductase 2.577e-10 0.42
NMDZ1_RAT Grin1 Glutamate receptor ionotropic, NMDA 1 3.029e-10 0.38
PARP1_HUMAN PARP1 Poly [ADP-ribose] polymerase 1 3.108e-10 0.39
POLG_DEN26 Genome polyprotein 3.133e-10 0.32
SC5A7_HUMAN SLC5A7 High affinity choline transporter 1 3.281e-10 0.37
NMDE3_RAT Grin2c Glutamate receptor ionotropic, NMDA 2C 3.481e-10 0.38
NK1R_RAT Tacr1 Substance-P receptor 3.684e-10 0.32
OPRK_RAT Oprk1 Kappa-type opioid receptor 5.041e-10 0.38
KPYK_STAAR pyk Pyruvate kinase 6.335e-10 0.37
BIRC2_HUMAN BIRC2 Baculoviral IAP repeat-containing protein 2 6.444e-10 0.49
HDAC6_HUMAN HDAC6 Histone deacetylase 6 6.469e-10 0.44
C3AR_HUMAN C3AR1 C3a anaphylatoxin chemotactic receptor 6.866e-10 0.31
IGF1R_HUMAN IGF1R Insulin-like growth factor 1 receptor 7.631e-10 0.33
PEPT1_DERPT DERP1 Peptidase 1 8.283e-10 0.34
NMUR1_HUMAN NMUR1 Neuromedin-U receptor 1 8.811e-10 0.28
O97467_PLAFA ht1 Hexose transporter 1 1.194e-09 0.40
LUCI_RENRE Coelenterazine h 2-monooxygenase 1.278e-09 0.34
CASR_HUMAN CASR Extracellular calcium-sensing receptor 1.336e-09 0.35
HRH1_HUMAN HRH1 Histamine H1 receptor 1.421e-09 0.45
MMP1_HUMAN MMP1 Interstitial collagenase 1.591e-09 0.34
SCN9A_MOUSE Scn9a Sodium channel protein type 9 subunit alpha 2.079e-09 0.42
NEP_HUMAN MME Neprilysin 2.248e-09 0.34
MDR1B_MOUSE Abcb1b ATP-dependent translocase ABCB1 3.818e-09 0.35
NMUR2_HUMAN NMUR2 Neuromedin-U receptor 2 4.155e-09 0.28
VMAT2_HUMAN SLC18A2 Synaptic vesicular amine transporter 4.205e-09 0.34
Q8WSF8_APLCA Soluble acetylcholine receptor 4.592e-09 0.29
Q9N1N9_HORSE BCHE Carboxylic ester hydrolase 4.816e-09 0.37
A0A286XTF2_CAVPO OPRD1 G_PROTEIN_RECEP_F1_2 domain-containing protein 4.874e-09 0.38
HYES_HUMAN EPHX2 Bifunctional epoxide hydrolase 2 4.91e-09 0.38
TIMP3_RAT Timp3 Metalloproteinase inhibitor 3 5.494e-09 0.32
MK10_HUMAN MAPK10 Mitogen-activated protein kinase 10 6.93e-09 0.38
NMDE1_RAT Grin2a Glutamate receptor ionotropic, NMDA 2A 6.967e-09 0.34
CATB_HUMAN CTSB Cathepsin B 8.899e-09 0.38
MTR1A_HUMAN MTNR1A Melatonin receptor type 1A 9.669e-09 0.49
ACES_RAT Ache Acetylcholinesterase 1.109e-08 0.38
5HT2B_HUMAN HTR2B 5-hydroxytryptamine receptor 2B 1.148e-08 0.54
EDNRB_PIG EDNRB Endothelin receptor type B 1.71e-08 0.38
MMP9_RAT Mmp9 Matrix metalloproteinase-9 1.782e-08 0.32
DRD4_RAT Drd4 D(4) dopamine receptor 2.701e-08 0.45
MMP7_HUMAN MMP7 Matrilysin 2.936e-08 0.32
CCR3_RAT Ccr3 C-C chemokine receptor type 3 3.19e-08 0.30
GRIA1_RAT Gria1 Glutamate receptor 1 3.811e-08 0.34
CCR1_HUMAN CCR1 C-C chemokine receptor type 1 4.22e-08 0.38
SC6A2_HUMAN SLC6A2 Sodium-dependent noradrenaline transporter 6.782e-08 0.42
UBE2N_HUMAN UBE2N Ubiquitin-conjugating enzyme E2 N 7.092e-08 0.34
LEG7_HUMAN LGALS7; LGALS7B Galectin-7 7.127e-08 0.29
DPP2_HUMAN DPP7 Dipeptidyl peptidase 2 7.18e-08 0.38
NAMPT_HUMAN NAMPT Nicotinamide phosphoribosyltransferase 8.46e-08 0.48
OXYR_RAT Oxtr Oxytocin receptor 9.084e-08 0.31
NK3R_HUMAN TACR3 Neuromedin-K receptor 1.076e-07 0.45
SC6A1_RAT Slc6a1 Sodium- and chloride-dependent GABA transporter 1 1.189e-07 0.29
MMP26_HUMAN MMP26 Matrix metalloproteinase-26 1.276e-07 0.30
5HT5A_HUMAN HTR5A 5-hydroxytryptamine receptor 5A 1.513e-07 0.34
BKRB1_RABIT BDKRB1 B1 bradykinin receptor 1.667e-07 0.29
GYRB_MYCS2 gyrB DNA gyrase subunit B 1.837e-07 0.32
V2R_RAT Avpr2 Vasopressin V2 receptor 1.864e-07 0.31
OPRM_MOUSE Oprm1 Mu-type opioid receptor 2.056e-07 0.32
SMAD3_HUMAN SMAD3 Mothers against decapentaplegic homolog 3 2.362e-07 0.29
DRD2_BOVIN DRD2 D(2) dopamine receptor 2.595e-07 0.36
CNR2_HUMAN CNR2 Cannabinoid receptor 2 2.731e-07 0.36
NTR1_HUMAN NTSR1 Neurotensin receptor type 1 2.938e-07 0.29
TTK_HUMAN TTK Dual specificity protein kinase TTK 2.985e-07 0.32
PDIA1_HUMAN P4HB Protein disulfide-isomerase 3.317e-07 0.33
CCR3_MOUSE Ccr3 Probable C-C chemokine receptor type 3 3.459e-07 0.30
RB_HUMAN RB1 Retinoblastoma-associated protein 3.513e-07 0.29
SFRP1_HUMAN SFRP1 Secreted frizzled-related protein 1 3.583e-07 0.30
HDA10_HUMAN HDAC10 Polyamine deacetylase HDAC10 3.855e-07 0.33
HRH3_CAVPO HRH3 Histamine H3 receptor 4.08e-07 0.33
FA10_BOVIN F10 Coagulation factor X 4.356e-07 0.37
ADCY5_HUMAN ADCY5 Adenylate cyclase type 5 5.282e-07 0.30
Q9WTR4_RAT Slc6a2 Transporter 5.34e-07 0.42
LKHA4_MOUSE Lta4h Leukotriene A-4 hydrolase 6.218e-07 0.33
NEP_RAT Mme Neprilysin 6.34e-07 0.37
A0A0C7ACN7_PSEAI pqsD 3-oxoacyl-ACP synthase 6.707e-07 0.29
TRPV1_HUMAN TRPV1 Transient receptor potential cation channel subfamily V member 1 6.919e-07 0.47
CP2D6_HUMAN CYP2D6 Cytochrome P450 2D6 8.013e-07 0.43
SSR3_MOUSE Sstr3 Somatostatin receptor type 3 8.851e-07 0.48
GTR1_HUMAN SLC2A1 Solute carrier family 2, facilitated glucose transporter member 1 9.55e-07 0.40
CP3A4_HUMAN CYP3A4 Cytochrome P450 3A4 1.108e-06 0.44
5HT2B_RAT Htr2b 5-hydroxytryptamine receptor 2B 1.172e-06 0.42
LEG9_HUMAN LGALS9 Galectin-9 1.24e-06 0.29
CXCR3_MOUSE Cxcr3 C-X-C chemokine receptor type 3 1.283e-06 0.28
FKB1A_RAT Fkbp1a Peptidyl-prolyl cis-trans isomerase FKBP1A 1.316e-06 0.30
Q0GMK6_RABIT CDK4 Cyclin-dependent kinase 4 1.339e-06 0.34
GLRA1_HUMAN GLRA1 Glycine receptor subunit alpha-1 1.356e-06 0.29
OPRK_HUMAN OPRK1 Kappa-type opioid receptor 1.711e-06 0.38
SGMR2_HUMAN TMEM97 Sigma intracellular receptor 2 1.84e-06 0.29
PRIO_MESAU PRNP Major prion protein 2.123e-06 0.29
FA10_HUMAN F10 Coagulation factor X 2.408e-06 0.36
CNR2_MOUSE Cnr2 Cannabinoid receptor 2 2.509e-06 0.34
DCNL1_HUMAN DCUN1D1 DCN1-like protein 1 2.518e-06 0.31
SMO_MOUSE Smo Smoothened homolog 2.537e-06 0.34
PARP2_HUMAN PARP2 Poly [ADP-ribose] polymerase 2 2.54e-06 0.35
HDAC4_HUMAN HDAC4 Histone deacetylase 4 2.612e-06 0.35
DPOLB_HUMAN POLB DNA polymerase beta 2.667e-06 0.37
O61059_LEIME LmGT2 Glucose transporter 2.678e-06 0.40
MMP17_HUMAN MMP17 Matrix metalloproteinase-17 2.794e-06 0.30
TRPM8_RAT Trpm8 Transient receptor potential cation channel subfamily M member 8 3.122e-06 0.37
5HT7R_RAT Htr7 5-hydroxytryptamine receptor 7 3.372e-06 0.38
CNR1_HUMAN CNR1 Cannabinoid receptor 1 3.47e-06 0.36
CP51A_HUMAN CYP51A1 Lanosterol 14-alpha demethylase 3.716e-06 0.30
GNRHR_RAT Gnrhr Gonadotropin-releasing hormone receptor 3.894e-06 0.33
GPR84_HUMAN GPR84 G-protein coupled receptor 84 4.083e-06 0.38
P96830_MYCTO TYR_PHOSPHATASE_2 domain-containing protein 4.128e-06 0.31
MMP15_HUMAN MMP15 Matrix metalloproteinase-15 4.4e-06 0.30
S22A8_HUMAN SLC22A8 Solute carrier family 22 member 8 4.586e-06 0.30
CP2CJ_HUMAN CYP2C19 Cytochrome P450 2C19 4.871e-06 0.46
PSB5_HUMAN PSMB5 Proteasome subunit beta type-5 4.894e-06 0.32
DRD5_HUMAN DRD5 D(1B) dopamine receptor 4.929e-06 0.51
CHIB_SERMA chiB Chitinase B 4.939e-06 0.34
RPA1_HUMAN POLR1A DNA-directed RNA polymerase I subunit RPA1 5.186e-06 0.29
CP2C9_HUMAN CYP2C9 Cytochrome P450 2C9 5.197e-06 0.44
TERT_HUMAN TERT Telomerase reverse transcriptase 5.215e-06 0.37
TAOK3_HUMAN TAOK3 Serine/threonine-protein kinase TAO3 6.177e-06 0.35
C11B1_RAT Cyp11b1 Cytochrome P450 11B1, mitochondrial 6.739e-06 0.32
TRAR_RHIRD traR Transcriptional activator protein TraR 7.111e-06 0.43
SC6A1_MOUSE Slc6a1 Sodium- and chloride-dependent GABA transporter 1 7.328e-06 0.29
O69002_PSEAI pigA Biliverdin-producing heme oxygenase 7.371e-06 0.31
SC6A3_RAT Slc6a3 Sodium-dependent dopamine transporter 7.831e-06 0.46
HDAC9_HUMAN HDAC9 Histone deacetylase 9 7.915e-06 0.33
CAN1_RAT Capn1 Calpain-1 catalytic subunit 8.279e-06 0.28
RENI_RAT Ren1 Renin 8.344e-06 0.30
PSB8_HUMAN PSMB8 Proteasome subunit beta type-8 8.683e-06 0.31

Sofosbuvir

Q8JXU8_9HEPC NS5B RNA-directed RNA polymerase 6.883e-15 1.00
POLG_HCV77 Genome polyprotein 2.653e-05 1.00
P2Y14_HUMAN P2RY14 P2Y purinoceptor 14 1.421e-142 0.46
P2RY6_HUMAN P2RY6 P2Y purinoceptor 6 6.421e-119 0.46
P2RY2_HUMAN P2RY2 P2Y purinoceptor 2 4.008e-103 0.46
P2RY4_HUMAN P2RY4 P2Y purinoceptor 4 1.447e-88 0.46
V5TFZ2_9FLAV Nonstructural protein 5 2.21e-71 0.46
SIAT1_HUMAN ST6GAL1 Beta-galactoside alpha-2,6-sialyltransferase 1 7.182e-66 0.33
RNAS1_HUMAN RNASE1 Ribonuclease pancreatic 6.33e-48 0.30
RNAS2_HUMAN RNASE2 Non-secretory ribonuclease 6.33e-48 0.30
P2RY2_RAT P2ry2 P2Y purinoceptor 2 2.027e-46 0.37
B4GT1_HUMAN B4GALT1 Beta-1,4-galactosyltransferase 1 8.172e-40 0.32
Q8II92_PLAF7 Deoxyuridine 5'-triphosphate nucleotidohydrolase 9.804e-39 0.35
CHS1_YEAST CHS1 Chitin synthase 1 1.775e-36 0.29
TYSY_MYCTU thyA Thymidylate synthase ThyA 2.43e-36 0.29
RNAS1_BOVIN RNASE1 Ribonuclease pancreatic 4.355e-36 0.32
TYSY_BOVIN TYMS Thymidylate synthase 1.221e-31 0.39
Q3ZDS5_9HEPC NS5B 3.185e-31 0.39
ENTP2_HUMAN ENTPD2 Ectonucleoside triphosphate diphosphohydrolase 2 9.756e-27 0.33
MRAY_STAAU mraY Phospho-N-acetylmuramoyl-pentapeptide-transferase 4.118e-26 0.29
DPOG1_HUMAN POLG DNA polymerase subunit gamma-1 2.866e-24 0.39
P2RY4_RAT P2ry4 P2Y purinoceptor 4 4.722e-23 0.37
A4TVL0_9PROT Cereblon isoform 4 5.225e-23 0.28
MRAY_BACSU mraY Phospho-N-acetylmuramoyl-pentapeptide-transferase 2.588e-20 0.32
MRAY_ECOLI mraY Phospho-N-acetylmuramoyl-pentapeptide-transferase 3.691e-19 0.30
THYX_MYCTU thyX Flavin-dependent thymidylate synthase 2.084e-18 0.31
KITH_RAT Tk1 Thymidine kinase, cytosolic 4.879e-18 0.29
O39930_9HEPC NS5b RNA-directed RNA polymerase 2.648e-17 0.42
P2RY6_RAT P2ry6 P2Y purinoceptor 6 4.119e-17 0.38
TYSY_LACCA thyA Thymidylate synthase 4.505e-17 0.39
P2RY2_MOUSE P2ry2 P2Y purinoceptor 2 6.328e-15 0.37
CRBN_HUMAN CRBN Protein cereblon 6.55e-15 0.28
OGT1_HUMAN OGT UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 4.574e-14 0.38
DPOLB_HUMAN POLB DNA polymerase beta 6.445e-11 0.39
ITPR1_RAT Itpr1 Inositol 1,4,5-trisphosphate receptor type 1 6.104e-10 0.29
CHS1_CANAX CHS1 Chitin synthase 1 2.041e-07 0.29
DPOLA_HUMAN POLA1 DNA polymerase alpha catalytic subunit 2.246e-07 0.29

Antazoline

TAAR1_HUMAN TAAR1 Trace amine-associated receptor 1 1.726e-12 1.00
CP2D6_HUMAN CYP2D6 Cytochrome P450 2D6 0.0002728 1.00
HRH1_CAVPO HRH1 Histamine H1 receptor 0.01077 1.00
NISCH_RAT Nisch Nischarin 2.26e-101 0.45
NISCH_HUMAN NISCH Nischarin 1.082e-96 0.46
ADA2B_HUMAN ADRA2B Alpha-2B adrenergic receptor 1.103e-40 0.41
ADA1A_HUMAN ADRA1A Alpha-1A adrenergic receptor 6.723e-38 0.41
G6PC_HUMAN G6PC Glucose-6-phosphatase 4.181e-36 0.33
ADA2C_HUMAN ADRA2C Alpha-2C adrenergic receptor 2.008e-35 0.41
ADA1D_HUMAN ADRA1D Alpha-1D adrenergic receptor 4.811e-34 0.41
ADA1B_HUMAN ADRA1B Alpha-1B adrenergic receptor 3.057e-33 0.38
ADA2A_HUMAN ADRA2A Alpha-2A adrenergic receptor 2.502e-29 0.40
ADA2A_BOVIN ADRA2A Alpha-2A adrenergic receptor 2.259e-20 0.56
EST1_PIG Liver carboxylesterase 1.11e-16 0.29
BKRB1_MACFA BDKRB1 B1 bradykinin receptor 3.664e-15 0.33
CETP_RABIT CETP Cholesteryl ester transfer protein 5.903e-10 0.29
MOT1_RAT Slc16a1 Monocarboxylate transporter 1 5.695e-08 0.34
5HT1D_HUMAN HTR1D 5-hydroxytryptamine receptor 1D 1.849e-07 0.45
5HT1B_HUMAN HTR1B 5-hydroxytryptamine receptor 1B 1.321e-06 0.48
BKRB1_RAT Bdkrb1 B1 bradykinin receptor 2.278e-06 0.30

Tiopronin

ACE_RABIT ACE Angiotensin-converting enzyme 4.258e-09 1.00
GSTA2_HUMAN GSTA2 Glutathione S-transferase A2 3.809e-49 0.31
AL1A2_CHICK ALDH1A2 Retinal dehydrogenase 2 1.046e-36 0.29
P4HA1_RAT P4ha1 Prolyl 4-hydroxylase subunit alpha-1 4.8e-34 0.42
GSTK1_HUMAN GSTK1 Glutathione S-transferase kappa 1 3.098e-32 0.40
NEP_MOUSE Mme Neprilysin 5.012e-26 0.30
LGUL_HUMAN GLO1 Lactoylglutathione lyase 6.725e-22 0.35
S15A1_HUMAN SLC15A1 Solute carrier family 15 member 1 3.198e-20 0.39
GSTM1_HUMAN GSTM1 Glutathione S-transferase Mu 1 1.007e-19 0.31
CBPA1_BOVIN CPA1 Carboxypeptidase A1 3.013e-19 0.33
NEP_HUMAN MME Neprilysin 3.751e-18 0.62
NEP_RAT Mme Neprilysin 1.998e-15 0.41
ACE2_HUMAN ACE2 Angiotensin-converting enzyme 2 1.01e-14 0.62
AMPB_HUMAN RNPEP Aminopeptidase B 2.176e-14 0.39
NEP_RABIT MME Neprilysin 4.019e-14 0.53
ACE_MOUSE Ace Angiotensin-converting enzyme 1.296e-13 0.30
BODG_PSESK Gamma-butyrobetaine dioxygenase 3.922e-13 0.29
PP2AA_BOVIN PPP2CA Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 6.449e-13 0.28
THER_BACTH npr Thermolysin 1.013e-12 0.41
ACE_HUMAN ACE Angiotensin-converting enzyme 3.411e-12 0.62
FTO_HUMAN FTO Alpha-ketoglutarate-dependent dioxygenase FTO 9.7e-12 0.29
GSP_CRIFA GSP Glutathionylspermidine synthase 1.275e-11 0.28
S15A2_RAT Slc15a2 Solute carrier family 15 member 2 1.972e-11 0.39
LGUL_YEAST GLO1 Lactoylglutathione lyase 7.306e-11 0.29
AL1A3_HUMAN ALDH1A3 Aldehyde dehydrogenase family 1 member A3 7.655e-11 0.29
S22A6_MOUSE Slc22a6 Solute carrier family 22 member 6 9.374e-11 0.31
AL1A2_HUMAN ALDH1A2 Retinal dehydrogenase 2 2.635e-09 0.29
GSTP1_HUMAN GSTP1 Glutathione S-transferase P 5.829e-09 0.31
PPM1B_HUMAN PPM1B Protein phosphatase 1B 1.813e-08 0.28
GSTA1_HUMAN GSTA1 Glutathione S-transferase A1 2.148e-08 0.31
KDM3A_HUMAN KDM3A Lysine-specific demethylase 3A 7.408e-08 0.42
AMPB_RAT Rnpep Aminopeptidase B 2.996e-07 0.30
GPR18_HUMAN GPR18 N-arachidonyl glycine receptor 1.069e-06 0.31
ECE1_HUMAN ECE1 Endothelin-converting enzyme 1 4.711e-06 0.53

Perampanel

GRIA1_HUMAN GRIA1 Glutamate receptor 1 8.639e-08 1.00
PDE4A_CAVPO PDE4A cAMP-specific 3',5'-cyclic phosphodiesterase 4A 1.948e-36 0.29
XDH_BOVIN XDH Xanthine dehydrogenase/oxidase 2.791e-35 0.34
PDIA6_HUMAN PDIA6 Protein disulfide-isomerase A6 2.717e-25 0.31
GRM5_HUMAN GRM5 Metabotropic glutamate receptor 5 5.65e-19 0.42
Q9XSW7_PIG Phosphodiesterase 3.488e-18 0.29
ISPD_ARATH ISPD 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic 3.442e-15 0.29
GRM5_RAT Grm5 Metabotropic glutamate receptor 5 6.661e-14 0.43
GBRB3_HUMAN GABRB3 Gamma-aminobutyric acid receptor subunit beta-3 4.516e-12 0.37
GBRA3_HUMAN GABRA3 Gamma-aminobutyric acid receptor subunit alpha-3 1.496e-11 0.37
GBRG2_HUMAN GABRG2 Gamma-aminobutyric acid receptor subunit gamma-2 2.476e-11 0.37
GBRA1_HUMAN GABRA1 Gamma-aminobutyric acid receptor subunit alpha-1 4.093e-11 0.37
HSP12_CAEEL hsp-16.2 Heat shock protein Hsp-16.2 1.087e-09 0.28
E1BN64_BOVIN PDE3B Phosphodiesterase 1.134e-08 0.29
UPAR_HUMAN PLAUR Urokinase plasminogen activator surface receptor 2.461e-08 0.34
Q38C41_TRYB2 Phosphotransferase 3.823e-07 0.29
PDE5A_RAT Pde5a cGMP-specific 3',5'-cyclic phosphodiesterase 1.203e-06 0.28
MAP11_HUMAN METAP1 Methionine aminopeptidase 1 1.504e-06 0.30
KDM3A_HUMAN KDM3A Lysine-specific demethylase 3A 3.101e-06 0.33

Isoconazole

CP17A_HUMAN CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase 6.074e-07 1.00
CP2D6_HUMAN CYP2D6 Cytochrome P450 2D6 4.894e-06 1.00
CP2C9_HUMAN CYP2C9 Cytochrome P450 2C9 0.000394 1.00
CP3A4_HUMAN CYP3A4 Cytochrome P450 3A4 0.001178 1.00
CP2CJ_HUMAN CYP2C19 Cytochrome P450 2C19 0.004147 1.00
CP1A2_HUMAN CYP1A2 Cytochrome P450 1A2 0.00659 1.00
CP121_MYCTU cyp121 Mycocyclosin synthase 4.373e-60 0.76
A2TEF2_LEIIN CYP51 Putative lanosterol 14-alpha-demethylase 4.521e-57 0.42
CP74A_ARATH CYP74A Allene oxide synthase, chloroplastic 4.247e-47 0.56
THAS_RAT Tbxas1 Thromboxane-A synthase 1.425e-45 0.37
HMOX1_RAT Hmox1 Heme oxygenase 1 1.333e-38 0.39
I23O2_MOUSE Ido2 Indoleamine 2,3-dioxygenase 2 1.765e-38 0.76
TRPM2_HUMAN TRPM2 Transient receptor potential cation channel subfamily M member 2 1.078e-29 0.76
HMOX2_RAT Hmox2 Heme oxygenase 2 2.311e-27 0.39
CP51_CANAL ERG11 Lanosterol 14-alpha demethylase 6.439e-26 0.42
CP51_MYCTU cyp51 Lanosterol 14-alpha demethylase 6.05e-23 0.76
CP27B_HUMAN CYP27B1 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial 4.909e-22 0.44
C11B1_HUMAN CYP11B1 Cytochrome P450 11B1, mitochondrial 1.213e-20 0.42
CP51A_HUMAN CYP51A1 Lanosterol 14-alpha demethylase 1.799e-19 0.76
CP17A_RAT Cyp17a1 Steroid 17-alpha-hydroxylase/17,20 lyase 2.22e-16 0.38
CPXA_PSEPU camC Camphor 5-monooxygenase 2.22e-16 0.31
ULK1_HUMAN ULK1 Serine/threonine-protein kinase ULK1 3.331e-16 0.76
LUXR_ALIFS luxR Transcriptional activator protein LuxR 1.776e-15 0.44
C11B2_HUMAN CYP11B2 Cytochrome P450 11B2, mitochondrial 1.41e-14 0.42
THAS_HUMAN TBXAS1 Thromboxane-A synthase 1.521e-14 0.76
TRPC6_MOUSE Trpc6 Short transient receptor potential channel 6 1.087e-12 0.34
CP19A_HUMAN CYP19A1 Aromatase 2.676e-12 0.56
CP26A_HUMAN CYP26A1 Cytochrome P450 26A1 5.043e-11 0.30
I23O1_HUMAN IDO1 Indoleamine 2,3-dioxygenase 1 1.748e-09 0.76
QPCT_HUMAN QPCT Glutaminyl-peptide cyclotransferase 3.328e-09 0.34
Q690N0_BOVIN PGR Progesterone receptor 3.706e-09 0.76
CP19A_RAT Cyp19a1 Aromatase 6.135e-07 0.33
CP51_TRYCC CYP51 Sterol 14-alpha demethylase 1.462e-06 0.42
PLAP_HUMAN PLAA Phospholipase A-2-activating protein 3.168e-06 0.28
Q8IL32_PLAF7 Heat shock protein 90, putative 5.204e-06 0.76

Isoxsuprine

CP2D6_HUMAN CYP2D6 Cytochrome P450 2D6 6.359e-06 1.00
CP1A2_HUMAN CYP1A2 Cytochrome P450 1A2 0.2591 1.00
CDK1_HUMAN CDK1 Cyclin-dependent kinase 1 0.4293 1.00
ADRB2_RAT Adrb2 Beta-2 adrenergic receptor 5.9e-87 0.47
ADRB3_RAT Adrb3 Beta-3 adrenergic receptor 1.012e-64 0.47
GPR88_HUMAN GPR88 Probable G-protein coupled receptor 88 1.915e-59 0.39
ERR3_MOUSE Esrrg Estrogen-related receptor gamma 3.152e-49 0.34
ADRB2_BOVIN ADRB2 Beta-2 adrenergic receptor 9.972e-46 0.47
ACER2_HUMAN ACER2 Alkaline ceramidase 2 8.654e-43 0.34
GPR88_MOUSE Gpr88 Probable G-protein coupled receptor 88 1.096e-40 0.32
Q8ILP4_PLAF7 Pantothenate kinase, putative 7.62e-36 0.28
B0FL73_CAVPO ADRB1 Beta-1 adrenergic receptor 8.489e-36 0.48
ADRB3_HUMAN ADRB3 Beta-3 adrenergic receptor 2.902e-32 0.45
ADRB2_CAVPO Adrb2 Beta-2 adrenergic receptor 1.51e-31 0.48
ADRB1_HUMAN ADRB1 Beta-1 adrenergic receptor 1.293e-30 0.45
SCYD_MAGO7 SDH1 Scytalone dehydratase 3.812e-26 0.42
ADRB1_RAT Adrb1 Beta-1 adrenergic receptor 1.999e-25 0.33
ADRB2_CANLF ADRB2 Beta-2 adrenergic receptor 5.26e-25 0.39
H9TVJ1_CHISP TyR1 1.418e-24 0.30
ADRB2_HUMAN ADRB2 Beta-2 adrenergic receptor 1.984e-23 0.47
ERR2_HUMAN ESRRB Steroid hormone receptor ERR2 6.129e-20 0.34
PDS_SYNE7 pds 15-cis-phytoene desaturase 4.755e-19 0.33
PPAP_HUMAN ACP3 Prostatic acid phosphatase 6.55e-15 0.29
NTCP_HUMAN SLC10A1 Sodium/bile acid cotransporter 8.793e-14 0.30
SCN4A_HUMAN SCN4A Sodium channel protein type 4 subunit alpha 4.84e-11 0.37
NMUR2_HUMAN NMUR2 Neuromedin-U receptor 2 8.636e-11 0.34
NMDE2_RAT Grin2b Glutamate receptor ionotropic, NMDA 2B 1.199e-10 0.61
LOX5_RAT Alox5 Arachidonate 5-lipoxygenase 1.401e-10 0.38
NMD3A_RAT Grin3a Glutamate receptor ionotropic, NMDA 3A 1.087e-09 0.28
PPO1_AGABI PPO1 Polyphenol oxidase 1 2.406e-09 0.29
ERR3_HUMAN ESRRG Estrogen-related receptor gamma 4.657e-09 0.30
LOX15_RAT Alox15 Arachidonate 15-lipoxygenase 9.961e-09 0.30
SCN1A_HUMAN SCN1A Sodium channel protein type 1 subunit alpha 3.893e-08 0.32
ADRB3_CANLF ADRB3 Beta-3 adrenergic receptor 5.431e-08 0.31
ESR1_HUMAN ESR1 Estrogen receptor 2.517e-07 0.34
SCN9A_MOUSE Scn9a Sodium channel protein type 9 subunit alpha 4.761e-07 0.32
CP26B_HUMAN CYP26B1 Cytochrome P450 26B1 5.533e-07 0.28
S22A3_HUMAN SLC22A3 Solute carrier family 22 member 3 5.973e-07 0.32
MDM4_HUMAN MDM4 Protein Mdm4 1.516e-06 0.32
NMDE2_HUMAN GRIN2B Glutamate receptor ionotropic, NMDA 2B 2.082e-06 0.39
LKHA4_HUMAN LTA4H Leukotriene A-4 hydrolase 3.418e-06 0.32
ACRO_PIG ACR Acrosin 5.328e-06 0.29
NPY5R_HUMAN NPY5R Neuropeptide Y receptor type 5 6.471e-06 0.38
PLEC_HUMAN PLEC Plectin 6.827e-06 0.30

Hexetidine

CP2D6_HUMAN CYP2D6 Cytochrome P450 2D6 0.7197 1.00

Hexestrol

CP2C9_HUMAN CYP2C9 Cytochrome P450 2C9 0.8544 1.00
CP3A4_HUMAN CYP3A4 Cytochrome P450 3A4 0.9641 1.00
H9TVJ1_CHISP TyR1 6.252e-61 0.44
SSDH_HUMAN ALDH5A1 Succinate-semialdehyde dehydrogenase, mitochondrial 6.694e-38 0.30
O87171_SPHPI lsdA Dioxygenase 1.248e-24 0.30
GABT_HUMAN ABAT 4-aminobutyrate aminotransferase, mitochondrial 2.158e-24 0.30
ESR1_HUMAN ESR1 Estrogen receptor 8.001e-21 0.66
ESR2_HUMAN ESR2 Estrogen receptor beta 2.312e-20 0.66
TAAR1_MACMU TAAR1 Trace amine-associated receptor 1 3.269e-19 0.38
TYRP1_MOUSE Tyrp1 5,6-dihydroxyindole-2-carboxylic acid oxidase 4.43e-19 0.30
PPO1_AGABI PPO1 Polyphenol oxidase 1 4.609e-18 0.30
MYG_HUMAN MB Myoglobin 2.22e-16 0.31
ADRB2_RAT Adrb2 Beta-2 adrenergic receptor 3.331e-16 0.36
TYRO_HUMAN TYR Tyrosinase 4.108e-15 0.35
ADRB2_BOVIN ADRB2 Beta-2 adrenergic receptor 1.477e-14 0.42
NMUR2_HUMAN NMUR2 Neuromedin-U receptor 2 6.106e-14 0.45
Q2PCB5_DICLA ca Carbonic anhydrase 8.976e-13 0.35
CAH3_HUMAN CA3 Carbonic anhydrase 3 5.791e-11 0.35
ERR3_HUMAN ESRRG Estrogen-related receptor gamma 7.827e-10 0.35
MTSI_SPISQ sssIM CPG DNA methylase 4.864e-09 0.28
SCN2A_RAT Scn2a Sodium channel protein type 2 subunit alpha 6.122e-09 0.33
ESR2_RAT Esr2 Estrogen receptor beta 8.003e-09 0.38
Q49PX0_9POXV N1L N1L 8.147e-09 0.31
Q3I4V7_CRYNV CAN2 Carbonic anhydrase 3.332e-08 0.33
DHB3_HUMAN HSD17B3 Testosterone 17-beta-dehydrogenase 3 3.573e-08 0.36
PPO2_AGABI PPO2 Polyphenol oxidase 2 1.943e-06 0.34
GABT_RAT Abat 4-aminobutyrate aminotransferase, mitochondrial 3.67e-06 0.32
H9B8T9_CAPHI CTSB Cathepsin B 6.789e-06 0.34
NALD2_HUMAN NAALAD2 N-acetylated-alpha-linked acidic dipeptidase 2 7.112e-06 0.29

Triptorelin

MC5R_MOUSE Mc5r Melanocortin receptor 5 3.631e-249 0.48
NTR2_HUMAN NTSR2 Neurotensin receptor type 2 3.192e-218 0.52
MC4R_MOUSE Mc4r Melanocortin receptor 4 7.395e-210 0.48
MC3R_MOUSE Mc3r Melanocortin receptor 3 1.334e-190 0.46
MSHR_MOUSE Mc1r Melanocyte-stimulating hormone receptor 5.518e-180 0.48
MSHR_HUMAN MC1R Melanocyte-stimulating hormone receptor 6.84e-170 0.55
LSHR_RAT Lhcgr Lutropin-choriogonadotropic hormone receptor 2.767e-156 0.60
CCKAR_CAVPO CCKAR Cholecystokinin receptor type A 6.377e-156 0.46
NTR1_HUMAN NTSR1 Neurotensin receptor type 1 2.237e-154 0.53
MC3R_HUMAN MC3R Melanocortin receptor 3 3.7e-145 0.55
NTR1_MOUSE Ntsr1 Neurotensin receptor type 1 1.902e-137 0.53
GRPR_MOUSE Grpr Gastrin-releasing peptide receptor 6.323e-137 0.42
CD36_RAT Cd36 Platelet glycoprotein 4 1.166e-132 0.42
OPRM_RAT Oprm1 Mu-type opioid receptor 7.002e-123 0.54
NTR1_RAT Ntsr1 Neurotensin receptor type 1 4.42e-119 0.50
RENI_RAT Ren1 Renin 5.3e-113 0.47
Q9R297_RAT Mlnr Motilin receptor 6.359e-113 0.46
GASR_HUMAN CCKBR Gastrin/cholecystokinin type B receptor 5.271e-108 0.47
MC4R_HUMAN MC4R Melanocortin receptor 4 1.36e-102 0.55
RENI_HUMAN REN Renin 3.167e-102 0.51
HLAA_HUMAN HLA-A HLA class I histocompatibility antigen, A alpha chain 4.651e-101 0.52
DSBA_ECOLI dsbA Thiol:disulfide interchange protein DsbA 1.267e-94 0.45
OPRD_RAT Oprd1 Delta-type opioid receptor 2.289e-94 0.50
KISSR_HUMAN KISS1R KiSS-1 receptor 5.39e-91 0.50
GASR_BOVIN CCKBR Gastrin/cholecystokinin type B receptor 2.407e-90 0.34
OPRM_CAVPO OPRM1 Mu-type opioid receptor 1.105e-88 0.54
OPRD_MOUSE Oprd1 Delta-type opioid receptor 4.342e-87 0.54
SORT_HUMAN SORT1 Sortilin 4.974e-87 0.49
PAR2_HUMAN F2RL1 Proteinase-activated receptor 2 1.433e-86 0.37
TRFR_HUMAN TRHR Thyrotropin-releasing hormone receptor 3.526e-86 0.46
QRFPR_HUMAN QRFPR Pyroglutamylated RF-amide peptide receptor 2.892e-84 0.38
GRPR_RAT Grpr Gastrin-releasing peptide receptor 3.058e-79 0.48
MMP11_MOUSE Mmp11 Stromelysin-3 6.022e-79 0.33
F1SH20_PIG TRHDE Uncharacterized protein 9.99e-78 0.41
TRFR_MOUSE Trhr Thyrotropin-releasing hormone receptor 1.573e-77 0.46
TETX_CLOTE tetX Tetanus toxin 1.935e-73 0.37
Q9ERT1_MOUSE TRH-R2 Thyrotropin-releasing hormone receptor 2 1.101e-70 0.46
EDNRB_RAT Ednrb Endothelin receptor type B 1.413e-70 0.53
STAT3_HUMAN STAT3 Signal transducer and activator of transcription 3 1.465e-70 0.42
CDYL2_HUMAN CDYL2 Chromodomain Y-like protein 2 2.335e-68 0.37
Q8CGM4_CAVPO OPRM1 Mu-opioid receptor 8.863e-68 0.38
TRFR_RAT Trhr Thyrotropin-releasing hormone receptor 5.803e-67 0.46
TMPS6_HUMAN TMPRSS6 Transmembrane protease serine 6 9.862e-67 0.43
ST14_MOUSE St14 Suppressor of tumorigenicity 14 protein homolog 3.073e-65 0.30
C3AR_HUMAN C3AR1 C3a anaphylatoxin chemotactic receptor 2.2e-64 0.56
GASR_RAT Cckbr Gastrin/cholecystokinin type B receptor 3.103e-64 0.40
SSR2_HUMAN SSTR2 Somatostatin receptor type 2 2.323e-61 0.35
PEPC_HUMAN PGC Gastricsin 1.249e-59 0.34
SURA_ECOLI surA Chaperone SurA 2.496e-59 0.47
EDNRA_MOUSE Ednra Endothelin-1 receptor 9.7e-59 0.42
NPFF2_RAT Npffr2 Neuropeptide FF receptor 2 1.549e-58 0.39
CBX7_HUMAN CBX7 Chromobox protein homolog 7 2.616e-58 0.37
TM11D_HUMAN TMPRSS11D Transmembrane protease serine 11D 6.603e-58 0.36
RENI1_MOUSE Ren1 Renin-1 1.947e-57 0.33
NMUR1_MOUSE Nmur1 Neuromedin-U receptor 1 3.922e-57 0.46
TRY1_BOVIN Cationic trypsin 2.625e-56 0.43
FURIN_HUMAN FURIN Furin 1.765e-55 0.41
MAGI3_HUMAN MAGI3 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 3.457e-55 0.38
NMUR1_HUMAN NMUR1 Neuromedin-U receptor 1 5.383e-55 0.48
NK2R_MESAU TACR2 Substance-K receptor 2.977e-54 0.39
MBOA4_HUMAN MBOAT4 Ghrelin O-acyltransferase 3.187e-53 0.29
PTPRC_HUMAN PTPRC Receptor-type tyrosine-protein phosphatase C 3.686e-53 0.41
EDNRA_PIG EDNRA Endothelin-1 receptor 7.445e-52 0.37
HGFA_HUMAN HGFAC Hepatocyte growth factor activator 1.071e-50 0.46
LCAP_HUMAN LNPEP Leucyl-cystinyl aminopeptidase 4.469e-49 0.45
CCKAR_MOUSE Cckar Cholecystokinin receptor type A 6.787e-49 0.41
SSR2_MOUSE Sstr2 Somatostatin receptor type 2 1.53e-48 0.33
BRCA1_HUMAN BRCA1 Breast cancer type 1 susceptibility protein 7.282e-48 0.30
FSHR_RAT Fshr Follicle-stimulating hormone receptor 8.588e-48 0.60
CCKAR_RAT Cckar Cholecystokinin receptor type A 6.96e-47 0.39
NRP1_RAT Nrp1 Neuropilin-1 1.145e-45 0.55
C5AR1_HUMAN C5AR1 C5a anaphylatoxin chemotactic receptor 1 3.225e-45 0.50
MMP11_HUMAN MMP11 Stromelysin-3 5.117e-45 0.30
Q5D7U5_CHICK OXTR Oxytocin-like receptor 5.513e-44 0.35
NPY4R_HUMAN NPY4R Neuropeptide Y receptor type 4 2.788e-42 0.38
NK1R_CAVPO TACR1 Substance-P receptor 5.316e-42 0.42
HEPS_HUMAN HPN Serine protease hepsin 8.303e-42 0.46
THRB_HUMAN F2 Prothrombin 2.007e-41 0.44
NPFF1_HUMAN NPFFR1 Neuropeptide FF receptor 1 2.661e-41 0.46
GHSR_RAT Ghsr Growth hormone secretagogue receptor type 1 4.701e-41 0.34
CBX4_HUMAN CBX4 E3 SUMO-protein ligase CBX4 5.265e-41 0.37
NPFF2_HUMAN NPFFR2 Neuropeptide FF receptor 2 1.301e-40 0.46
NK1R_RAT Tacr1 Substance-P receptor 2.015e-40 0.52
NMBR_HUMAN NMBR Neuromedin-B receptor 2.873e-40 0.42
HMDH_MESAU HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1.112e-39 0.33
OPRK_MOUSE Oprk1 Kappa-type opioid receptor 3.675e-39 0.40
NEC1_HUMAN PCSK1 Neuroendocrine convertase 1 4.522e-39 0.31
PCSK5_HUMAN PCSK5 Proprotein convertase subtilisin/kexin type 5 4.522e-39 0.31
ECE1_BOVIN ECE1 Endothelin-converting enzyme 1 1.015e-37 0.31
NMUR2_HUMAN NMUR2 Neuromedin-U receptor 2 1.357e-37 0.48
CATE_HUMAN CTSE Cathepsin E 7.542e-37 0.34
CBX5_HUMAN CBX5 Chromobox protein homolog 5 9.814e-36 0.28
G1FEK8_9CALI Protease 1.29e-35 0.28
I1U3K2_9CALI POL Nonstructural polyprotein 1.29e-35 0.28
BXA1_CLOBH botA Botulinum neurotoxin type A 1.799e-35 0.30
PEPA_PIG PGA Pepsin A 3.515e-35 0.47
OPRK_RAT Oprk1 Kappa-type opioid receptor 2.353e-34 0.50
Q8I6Z5_PLAF7 Plasmepsin V 2.507e-34 0.35
PGTB1_RAT Pggt1b Geranylgeranyl transferase type-1 subunit beta 5.963e-34 0.42
PCSK6_HUMAN PCSK6 Proprotein convertase subtilisin/kexin type 6 6.992e-33 0.31
SYMC_HUMAN MARS1 Methionine--tRNA ligase, cytoplasmic 7.834e-33 0.32
GHSR_HUMAN GHSR Growth hormone secretagogue receptor type 1 4.544e-31 0.45
OPRD_HUMAN OPRD1 Delta-type opioid receptor 8.999e-31 0.54
ECE1_HUMAN ECE1 Endothelin-converting enzyme 1 2.78e-30 0.35
ST14_HUMAN ST14 Suppressor of tumorigenicity 14 protein 3.556e-30 0.46
MC5R_HUMAN MC5R Melanocortin receptor 5 4.179e-30 0.41
NK2R_RAT Tacr2 Substance-K receptor 9.373e-29 0.38
EDNRA_HUMAN EDNRA Endothelin-1 receptor 2.988e-28 0.47
CFAB_HUMAN CFB Complement factor B 8.323e-28 0.44
CCKAR_HUMAN CCKAR Cholecystokinin receptor type A 1.37e-27 0.40
MMP8_HUMAN MMP8 Neutrophil collagenase 1.589e-27 0.36
NMBR_RAT Nmbr Neuromedin-B receptor 8.014e-27 0.33
CARP_YEAST PEP4 Saccharopepsin 8.165e-27 0.33
CATZ_RAT Ctsz Cathepsin Z 3.493e-26 0.32
BRS3_HUMAN BRS3 Bombesin receptor subtype-3 3.701e-26 0.34
CTRL_HUMAN CTRL Chymotrypsin-like protease CTRL-1 1.961e-25 0.31
STAT6_HUMAN STAT6 Signal transducer and activator of transcription 6 2.435e-25 0.37
AMPN_HUMAN ANPEP Aminopeptidase N 5.169e-25 0.45
A4HSF7_LEIIN TRYR Trypanothione reductase 1.655e-24 0.30
CP125_MYCTU cyp125 Steroid C26-monooxygenase 2.888e-24 0.30
MMP14_HUMAN MMP14 Matrix metalloproteinase-14 4.705e-24 0.33
OXYR_HUMAN OXTR Oxytocin receptor 8.644e-24 0.38
NK3R_CAVPO TACR3 Neuromedin-K receptor 1.26e-23 0.39
OPRM_HUMAN OPRM1 Mu-type opioid receptor 1.624e-23 0.52
CBX8_HUMAN CBX8 Chromobox protein homolog 8 2.21e-23 0.29
XIAP_HUMAN XIAP E3 ubiquitin-protein ligase XIAP 3.381e-23 0.45
ELAS_PSEAE lasB Elastase 4.113e-23 0.34
TR10A_HUMAN TNFRSF10A Tumor necrosis factor receptor superfamily member 10A 4.989e-23 0.28
Q9N6S8_PLAFA Cysteine proteinase falcipain 2a 6.188e-23 0.39
TMPS2_HUMAN TMPRSS2 Transmembrane protease serine 2 2.457e-22 0.36
V1BR_HUMAN AVPR1B Vasopressin V1b receptor 2.651e-22 0.35
ACKR3_HUMAN ACKR3 Atypical chemokine receptor 3 3.765e-22 0.37
NK2R_RABIT TACR2 Substance-K receptor 1.307e-21 0.38
GNRHR_RAT Gnrhr Gonadotropin-releasing hormone receptor 1.774e-21 0.51
VM1B1_BOTAS Snake venom metalloproteinase BaP1 2.174e-20 0.32
CATJ_RAT Ctsj Cathepsin J 2.849e-20 0.32
OXYR_MOUSE Oxtr Oxytocin receptor 3.04e-20 0.32
RIR1_MYCTU nrdE Ribonucleoside-diphosphate reductase subunit alpha 3.063e-20 0.32
OPRM_MOUSE Oprm1 Mu-type opioid receptor 3.508e-20 0.50
IDE_HUMAN IDE Insulin-degrading enzyme 3.925e-20 0.39
TYRO_HUMAN TYR Tyrosinase 4.44e-20 0.35
NCOR2_HUMAN NCOR2 Nuclear receptor corepressor 2 4.619e-20 0.34
NEP_RABIT MME Neprilysin 5.292e-20 0.31
ECE1_RAT Ece1 Endothelin-converting enzyme 1 7.189e-20 0.31
ACE_HUMAN ACE Angiotensin-converting enzyme 1.862e-19 0.54
NMDE1_RAT Grin2a Glutamate receptor ionotropic, NMDA 2A 1.91e-19 0.32
V2R_PIG AVPR2 Vasopressin V2 receptor 2.752e-19 0.36
HDA11_HUMAN HDAC11 Histone deacetylase 11 8.533e-19 0.32
PAR1_HUMAN F2R Proteinase-activated receptor 1 8.643e-19 0.39
GHRHR_RAT Ghrhr Growth hormone-releasing hormone receptor 8.825e-19 0.29
AGTR2_HUMAN AGTR2 Type-2 angiotensin II receptor 3.188e-18 0.55
Q9ERC0_RAT Npy2r Neuropeptide Y receptor Y2 4.879e-18 0.29
PLMN_HUMAN PLG Plasminogen 6.655e-18 0.38
NEC2_HUMAN PCSK2 Neuroendocrine convertase 2 6.663e-18 0.28
MMP2_HUMAN MMP2 72 kDa type IV collagenase 6.697e-18 0.36
GRIA1_RAT Gria1 Glutamate receptor 1 8.527e-18 0.32
CATC_RAT Ctsc Dipeptidyl peptidase 1 1.11e-16 0.32
MMP9_HUMAN MMP9 Matrix metalloproteinase-9 1.11e-16 0.36
OPRK_CAVPO OPRK1 Kappa-type opioid receptor 1.11e-16 0.50
ACE_RAT Ace Angiotensin-converting enzyme 3.331e-16 0.31
CTRA_BOVIN Chymotrypsinogen A 4.441e-16 0.33
CTRC_HUMAN CTRC Chymotrypsin-C 1.11e-15 0.35
CCNA2_HUMAN CCNA2 Cyclin-A2 1.776e-15 0.49
HDA10_HUMAN HDAC10 Polyamine deacetylase HDAC10 2.22e-15 0.32
SIA4A_HUMAN ST3GAL1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 2.22e-15 0.29
FNTB_RAT Fntb Protein farnesyltransferase subunit beta 3.442e-15 0.46
FNTA_RAT Fnta Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha 4.441e-15 0.46
MRP2_RAT Abcc2 Canalicular multispecific organic anion transporter 1 6.994e-15 0.37
CMA1_HUMAN CMA1 Chymase 1.921e-14 0.35
PLK1_HUMAN PLK1 Serine/threonine-protein kinase PLK1 2.109e-14 0.38
ITB1_HUMAN ITGB1 Integrin beta-1 2.121e-14 0.34
KLK3_HUMAN KLK3 Prostate-specific antigen 2.365e-14 0.31
MMP1_HUMAN MMP1 Interstitial collagenase 2.576e-14 0.35
B3DH72_DANRE oprd1b Opioid receptor, delta 1b 3.73e-14 0.35
O57585_DANRE oprd1a Opioid receptor homologue 3.73e-14 0.35
CBPN_HUMAN CPN1 Carboxypeptidase N catalytic chain 6.506e-14 0.32
GASR_MOUSE Cckbr Gastrin/cholecystokinin type B receptor 6.528e-14 0.40
ITAV_HUMAN ITGAV Integrin alpha-V 7.661e-14 0.41
PSB8_HUMAN PSMB8 Proteasome subunit beta type-8 8.882e-14 0.30
ADA12_HUMAN ADAM12 Disintegrin and metalloproteinase domain-containing protein 12 9.504e-14 0.30
EDNRA_RAT Ednra Endothelin-1 receptor 1.191e-13 0.38
ENV_HV1H2 env Envelope glycoprotein gp160 1.267e-13 0.30
V1AR_HUMAN AVPR1A Vasopressin V1a receptor 1.37e-13 0.42
XPP1_HUMAN XPNPEP1 Xaa-Pro aminopeptidase 1 3.164e-13 0.29
DRB3_HUMAN HLA-DRB3 HLA class II histocompatibility antigen, DR beta 3 chain 4.075e-13 0.36
PCSK7_HUMAN PCSK7 Proprotein convertase subtilisin/kexin type 7 4.904e-13 0.28
Q98UH1_DANRE oprm1 Mu opioid receptor-like OR2 7.25e-13 0.35
FA10_BOVIN F10 Coagulation factor X 1.011e-12 0.38
GRPR_HUMAN GRPR Gastrin-releasing peptide receptor 1.237e-12 0.42
OXYR_RAT Oxtr Oxytocin receptor 1.508e-12 0.37
NTR2_RAT Ntsr2 Neurotensin receptor type 2 1.836e-12 0.49
CCND1_HUMAN CCND1 G1/S-specific cyclin-D1 2.111e-12 0.38
SIR1_HUMAN SIRT1 NAD-dependent protein deacetylase sirtuin-1 2.967e-12 0.40
CELA1_HUMAN CELA1 Chymotrypsin-like elastase family member 1 3.261e-12 0.29
MRGX1_MOUSE Mrgprx1 Mas-related G-protein coupled receptor member X1 5.251e-12 0.29
THER_BACTH npr Thermolysin 5.332e-12 0.34
NK3R_RAT Tacr3 Neuromedin-K receptor 7.631e-12 0.31
Q91H74_9FLAV Genome polyprotein 8.939e-12 0.36
FKBP5_HUMAN FKBP5 Peptidyl-prolyl cis-trans isomerase FKBP5 1.204e-11 0.30
PLMN_BOVIN PLG Plasminogen 1.315e-11 0.28
TRY3_HUMAN PRSS3 Trypsin-3 1.92e-11 0.31
PPCE_MOUSE Prep Prolyl endopeptidase 2.015e-11 0.31
RIR1_HUMAN RRM1 Ribonucleoside-diphosphate reductase large subunit 2.099e-11 0.31
V1AR_RAT Avpr1a Vasopressin V1a receptor 2.291e-11 0.37
O68720_YERPE yopH Targeted effector protein 3.008e-11 0.29
ERAP2_HUMAN ERAP2 Endoplasmic reticulum aminopeptidase 2 3.228e-11 0.33
SSR3_HUMAN SSTR3 Somatostatin receptor type 3 3.576e-11 0.31
AMD_HUMAN PAM Peptidyl-glycine alpha-amidating monooxygenase 3.83e-11 0.35
HDAC3_HUMAN HDAC3 Histone deacetylase 3 5.284e-11 0.34
V1BR_RAT Avpr1b Vasopressin V1b receptor 5.431e-11 0.37
CATB_RAT Ctsb Cathepsin B 7.419e-11 0.32
PRTN3_HUMAN PRTN3 Myeloblastin 7.434e-11 0.32
XPP2_RAT Xpnpep2 Xaa-Pro aminopeptidase 2 9.3e-11 0.29
CASPA_HUMAN CASP10 Caspase-10 9.374e-11 0.31
V2R_HUMAN AVPR2 Vasopressin V2 receptor 9.892e-11 0.35
MCA2_TRYBB MCA2 Metacaspase 1.068e-10 0.31
NEP_RAT Mme Neprilysin 1.244e-10 0.40
GLNA_HUMAN GLUL Glutamine synthetase 1.7e-10 0.33
TAT_HV1H2 tat Protein Tat 1.8e-10 0.31
SSR5_HUMAN SSTR5 Somatostatin receptor type 5 1.921e-10 0.30
PLK2_HUMAN PLK2 Serine/threonine-protein kinase PLK2 2.277e-10 0.35
SSR4_HUMAN SSTR4 Somatostatin receptor type 4 2.864e-10 0.31
CATL1_HUMAN CTSL Cathepsin L1 3.256e-10 0.38
MMP8_RAT Mmp8 Neutrophil collagenase 4.574e-10 0.32
CATD_HUMAN CTSD Cathepsin D 1.223e-09 0.35
NPY1R_HUMAN NPY1R Neuropeptide Y receptor type 1 1.376e-09 0.32
PPIG_HUMAN PPIG Peptidyl-prolyl cis-trans isomerase G 1.445e-09 0.30
OPRK_HUMAN OPRK1 Kappa-type opioid receptor 1.707e-09 0.50
PIN1_HUMAN PIN1 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 1.759e-09 0.32
MRAY_STAAU mraY Phospho-N-acetylmuramoyl-pentapeptide-transferase 1.845e-09 0.30
HDAC8_HUMAN HDAC8 Histone deacetylase 8 2.712e-09 0.34
HDAC2_HUMAN HDAC2 Histone deacetylase 2 2.745e-09 0.34
KEAP1_HUMAN KEAP1 Kelch-like ECH-associated protein 1 3.107e-09 0.34
XPP2_HUMAN XPNPEP2 Xaa-Pro aminopeptidase 2 3.108e-09 0.29
TRY1_HUMAN PRSS1 Trypsin-1 3.452e-09 0.39
PAPA1_CARPA Papain 4.492e-09 0.41
SSR1_HUMAN SSTR1 Somatostatin receptor type 1 6.32e-09 0.31
MMP7_HUMAN MMP7 Matrilysin 7.752e-09 0.37
CATG_HUMAN CTSG Cathepsin G 8.076e-09 0.30
PSB9_HUMAN PSMB9 Proteasome subunit beta type-9 8.665e-09 0.29
S15A2_RAT Slc15a2 Solute carrier family 15 member 2 1.043e-08 0.29
HMDH_HUMAN HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1.536e-08 0.37
CATD_BOVIN CTSD Cathepsin D 1.985e-08 0.32
MEN1_HUMAN MEN1 Menin 2.223e-08 0.55
NK2R_HUMAN TACR2 Substance-K receptor 2.871e-08 0.46
UR2R_RAT Uts2r Urotensin-2 receptor 3.01e-08 0.41
NK1R_HUMAN TACR1 Substance-P receptor 3.55e-08 0.54
PLMN_RAT Plg Plasminogen 3.568e-08 0.37
V2R_RAT Avpr2 Vasopressin V2 receptor 3.772e-08 0.37
CP51_TRYCC CYP51 Sterol 14-alpha demethylase 4.371e-08 0.30
FA11_HUMAN F11 Coagulation factor XI 4.416e-08 0.37
CBPA1_HUMAN CPA1 Carboxypeptidase A1 1.041e-07 0.32
MMP26_HUMAN MMP26 Matrix metalloproteinase-26 1.106e-07 0.30
NEP_HUMAN MME Neprilysin 1.74e-07 0.33
OPRX_HUMAN OPRL1 Nociceptin receptor 1.861e-07 0.36
PPID_HUMAN PPID Peptidyl-prolyl cis-trans isomerase D 2.477e-07 0.30
ERAP1_HUMAN ERAP1 Endoplasmic reticulum aminopeptidase 1 2.7e-07 0.32
UBC9_HUMAN UBE2I SUMO-conjugating enzyme UBC9 3.151e-07 0.30
PCP_HUMAN PRCP Lysosomal Pro-X carboxypeptidase 3.299e-07 0.31
ITB8_HUMAN ITGB8 Integrin beta-8 3.577e-07 0.30
GRB2_HUMAN GRB2 Growth factor receptor-bound protein 2 3.578e-07 0.34
CAN1_HUMAN CAPN1 Calpain-1 catalytic subunit 5.076e-07 0.46
PPIA_HUMAN PPIA Peptidyl-prolyl cis-trans isomerase A 6.611e-07 0.38
ITA5_HUMAN ITGA5 Integrin alpha-5 7.647e-07 0.33
FA7_HUMAN F7 Coagulation factor VII 7.657e-07 0.37
CATB_BOVIN CTSB Cathepsin B 1.206e-06 0.31
ADCY5_HUMAN ADCY5 Adenylate cyclase type 5 1.221e-06 0.28
THRB_BOVIN F2 Prothrombin 1.296e-06 0.38
Q82323_9DELA Protease 1.675e-06 0.31
Q72874_9HIV1 pol Pol polyprotein 1.977e-06 0.40
CASP5_HUMAN CASP5 Caspase-5 2.175e-06 0.31
DRD1_HUMAN DRD1 D(1A) dopamine receptor 2.28e-06 0.40
MMP17_HUMAN MMP17 Matrix metalloproteinase-17 2.488e-06 0.30
BMP1_HUMAN BMP1 Bone morphogenetic protein 1 2.516e-06 0.32
ITB3_HUMAN ITGB3 Integrin beta-3 2.951e-06 0.41
CTRB1_HUMAN CTRB1 Chymotrypsinogen B 3.415e-06 0.30
BIRC3_HUMAN BIRC3 Baculoviral IAP repeat-containing protein 3 3.598e-06 0.31
MMP15_HUMAN MMP15 Matrix metalloproteinase-15 3.933e-06 0.30
ITA4_HUMAN ITGA4 Integrin alpha-4 4.086e-06 0.34
FPR1_HUMAN FPR1 fMet-Leu-Phe receptor 4.574e-06 0.36
CXCR4_HUMAN CXCR4 C-X-C chemokine receptor type 4 4.906e-06 0.34
R1AB_SARS rep Replicase polyprotein 1ab 4.923e-06 0.31
TRY2_BOVIN Anionic trypsin 5.609e-06 0.35
MMP3_HUMAN MMP3 Stromelysin-1 7.044e-06 0.35
TRYB1_HUMAN TPSAB1 Tryptase alpha/beta-1 7.203e-06 0.39
CAN2_HUMAN CAPN2 Calpain-2 catalytic subunit 7.759e-06 0.31
MRGX1_RAT Mrgprx1 Mas-related G-protein coupled receptor member X1 8.03e-06 0.29
TAOK3_HUMAN TAOK3 Serine/threonine-protein kinase TAO3 9.896e-06 0.33

Mirabegron

ADRB3_HUMAN ADRB3 Beta-3 adrenergic receptor 1.518e-234 0.81
ADRB1_HUMAN ADRB1 Beta-1 adrenergic receptor 6.53e-188 0.81
ADRB2_HUMAN ADRB2 Beta-2 adrenergic receptor 5.613e-139 0.81
ADRB3_CANLF ADRB3 Beta-3 adrenergic receptor 5.749e-101 0.43
ADRB3_MACMU ADRB3 Beta-3 adrenergic receptor 3.018e-46 0.39
GLSL_MOUSE Gls2 Glutaminase liver isoform, mitochondrial 1.381e-38 0.31
NCS1_HUMAN NCS1 Neuronal calcium sensor 1 7.101e-36 0.28
Q9VWX8_DROME Frq2 FI18190p1 7.101e-36 0.28
ENPP2_MOUSE Enpp2 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 1.989e-32 0.34
AOC3_HUMAN AOC3 Membrane primary amine oxidase 1.063e-23 0.38
BLAN1_KLEPN blaNDM-1 Metallo-beta-lactamase type 2 3.756e-23 0.32
GLSK_HUMAN GLS Glutaminase kidney isoform, mitochondrial 1.559e-21 0.33
ADRB3_RAT Adrb3 Beta-3 adrenergic receptor 1.961e-20 0.39
ADRB2_CAVPO Adrb2 Beta-2 adrenergic receptor 1.037e-18 0.43
LKHA4_HUMAN LTA4H Leukotriene A-4 hydrolase 2.046e-17 0.34
AOC3_RAT Aoc3 Membrane primary amine oxidase 4.441e-16 0.38
ADRB1_MOUSE Adrb1 Beta-1 adrenergic receptor 1.443e-15 0.32
RORG_MOUSE Rorc Nuclear receptor ROR-gamma 1.832e-14 0.30
RORG_HUMAN RORC Nuclear receptor ROR-gamma 2.017e-13 0.36
SMS1_HUMAN SGMS1 Phosphatidylcholine:ceramide cholinephosphotransferase 1 1.532e-12 0.31
PTPRB_HUMAN PTPRB Receptor-type tyrosine-protein phosphatase beta 1.664e-11 0.33
SPHK1_HUMAN SPHK1 Sphingosine kinase 1 3.357e-10 0.30
SYFA_STAAU pheS Phenylalanine--tRNA ligase alpha subunit 8.001e-10 0.29
FNTB_HUMAN FNTB Protein farnesyltransferase subunit beta 1.494e-09 0.37
EAA3_HUMAN SLC1A1 Excitatory amino acid transporter 3 2.312e-09 0.33
EAA2_HUMAN SLC1A2 Excitatory amino acid transporter 2 2.996e-09 0.33
PFKA_TRYCC pfk ATP-dependent 6-phosphofructokinase 5.344e-09 0.28
LDHA_HUMAN LDHA L-lactate dehydrogenase A chain 5.575e-09 0.32
FNTA_HUMAN FNTA Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha 5.873e-09 0.37
ANM3_HUMAN PRMT3 Protein arginine N-methyltransferase 3 1.876e-08 0.36
PFKA_TRYBB pfk ATP-dependent 6-phosphofructokinase 2.042e-08 0.28
SC6A5_HUMAN SLC6A5 Sodium- and chloride-dependent glycine transporter 2 4.146e-08 0.32
CAH5B_HUMAN CA5B Carbonic anhydrase 5B, mitochondrial 8.915e-08 0.34
B0FL73_CAVPO ADRB1 Beta-1 adrenergic receptor 1.009e-07 0.32
CAH5A_HUMAN CA5A Carbonic anhydrase 5A, mitochondrial 1.257e-07 0.34
TRYB1_HUMAN TPSAB1 Tryptase alpha/beta-1 2.638e-07 0.30
Q6FTL6_CANGA NCE103 Carbonic anhydrase 2.823e-07 0.34
ERAP2_HUMAN ERAP2 Endoplasmic reticulum aminopeptidase 2 3.066e-07 0.34
TAAR1_HUMAN TAAR1 Trace amine-associated receptor 1 3.735e-07 0.35
ROCK1_HUMAN ROCK1 Rho-associated protein kinase 1 6.176e-07 0.34
CAN_CANAL NCE103 Carbonic anhydrase 1.039e-06 0.34
ADRB1_RAT Adrb1 Beta-1 adrenergic receptor 1.195e-06 0.31
ALBU_HUMAN ALB Serum albumin 1.21e-06 0.28
SRBP2_HUMAN SREBF2 Sterol regulatory element-binding protein 2 1.7e-06 0.30
MDR1_HUMAN ABCB1 ATP-dependent translocase ABCB1 4.951e-06 0.32
CAC1C_HUMAN CACNA1C Voltage-dependent L-type calcium channel subunit alpha-1C 8.551e-06 0.58

Azilsartan_medoxomil

ACATN_HUMAN SLC33A1 Acetyl-coenzyme A transporter 1 5.966e-219 0.40
AGTR1_BOVIN AGTR1 Type-1 angiotensin II receptor 4.123e-208 0.72
AGTR1_RABIT AGTR1 Type-1 angiotensin II receptor 1.114e-101 0.54
AGTRB_RAT Agtr1b Type-1B angiotensin II receptor 4.145e-87 0.38
AGTR1_HUMAN AGTR1 Type-1 angiotensin II receptor 3.923e-73 0.54
AGTRA_RAT Agtr1 Type-1A angiotensin II receptor 4.115e-70 0.54
AGTR2_HUMAN AGTR2 Type-2 angiotensin II receptor 3.021e-36 0.37
A8K2H7_HUMAN C3AR1 Complement component 3a receptor 1, isoform CRA_a 3.055e-33 0.35
AGTR2_RAT Agtr2 Type-2 angiotensin II receptor 9.718e-31 0.45
POLI_HUMAN POLI DNA polymerase iota 3.907e-27 0.44
AGTR1_CAVPO AGTR1 Type-1 angiotensin II receptor 2.462e-26 0.36
GPVI_HUMAN GP6 Platelet glycoprotein VI 2.847e-23 0.29
PPARG_HUMAN PPARG Peroxisome proliferator-activated receptor gamma 1.225e-18 0.43
POLK_HUMAN POLK DNA polymerase kappa 1.6e-17 0.44
Q581W1_TRYB2 Pteridine reductase, putative 1.066e-13 0.30
FOS_HUMAN FOS Proto-oncogene c-Fos 4.999e-09 0.29
BGLR_HUMAN GUSB Beta-glucuronidase 2.299e-07 0.28

Hydroxydione

S5A2_HUMAN SRD5A2 3-oxo-5-alpha-steroid 4-dehydrogenase 2 3.466e-190 0.44
S5A1_HUMAN SRD5A1 3-oxo-5-alpha-steroid 4-dehydrogenase 1 2.037e-130 0.44
G6PD_HUMAN G6PD Glucose-6-phosphate 1-dehydrogenase 1.111e-128 0.65
GBRD_HUMAN GABRD Gamma-aminobutyric acid receptor subunit delta 6.425e-113 0.47
CBG_HUMAN SERPINA6 Corticosteroid-binding globulin 6.224e-83 0.66
ANDR_RAT Ar Androgen receptor 5.888e-78 0.66
SHBG_HUMAN SHBG Sex hormone-binding globulin 1.868e-73 0.66
3BHS1_HUMAN HSD3B1 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 9.792e-61 0.35
S22A3_RAT Slc22a3 Solute carrier family 22 member 3 6.079e-60 0.55
NR1I3_MOUSE Nr1i3 Nuclear receptor subfamily 1 group I member 3 2.772e-54 0.57
SHBG_RAT Shbg Sex hormone-binding globulin 1.358e-52 0.66
GBRA4_HUMAN GABRA4 Gamma-aminobutyric acid receptor subunit alpha-4 2.39e-45 0.47
SIA4B_RAT St3gal2 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 3.343e-45 0.32
GBRB2_HUMAN GABRB2 Gamma-aminobutyric acid receptor subunit beta-2 4.794e-42 0.49
DHB7_HUMAN HSD17B7 3-keto-steroid reductase 2.04e-38 0.32
SMT1_ARATH SMT1 Cycloartenol-C-24-methyltransferase 1.768e-35 0.29
Q9GRG7_9TRYP g6pd Glucose-6-phosphate 1-dehydrogenase 4.475e-33 0.41
S22A2_RAT Slc22a2 Solute carrier family 22 member 2 1.181e-32 0.55
DHB3_HUMAN HSD17B3 Testosterone 17-beta-dehydrogenase 3 1.922e-32 0.41
SO1A1_RAT Slco1a1 Solute carrier organic anion transporter family member 1A1 3.039e-32 0.43
MRP4_HUMAN ABCC4 Multidrug resistance-associated protein 4 7.136e-30 0.32
S5A1_RAT Srd5a1 3-oxo-5-alpha-steroid 4-dehydrogenase 1 3.497e-28 0.38
S5A2_RAT Srd5a2 3-oxo-5-alpha-steroid 4-dehydrogenase 2 2.762e-25 0.38
EPHA2_MOUSE Epha2 Ephrin type-A receptor 2 1.244e-24 0.32
GBRG1_RAT Gabrg1 Gamma-aminobutyric acid receptor subunit gamma-1 2.422e-24 0.38
DHB3_RAT Hsd17b3 Testosterone 17-beta-dehydrogenase 3 3.219e-23 0.41
ADCYA_HUMAN ADCY10 Adenylate cyclase type 10 8.429e-23 0.36
NMDE3_HUMAN GRIN2C Glutamate receptor ionotropic, NMDA 2C 1.464e-21 0.34
GPBAR_HUMAN GPBAR1 G-protein coupled bile acid receptor 1 1.244e-20 0.76
Q690N0_BOVIN PGR Progesterone receptor 7.441e-20 0.66
NMDE4_HUMAN GRIN2D Glutamate receptor ionotropic, NMDA 2D 5.368e-18 0.34
GBRA1_HUMAN GABRA1 Gamma-aminobutyric acid receptor subunit alpha-1 2.06e-17 0.49
ANDR_MOUSE Ar Androgen receptor 2.176e-17 0.66
S22A3_HUMAN SLC22A3 Solute carrier family 22 member 3 1.11e-16 0.43
GABR1_RAT Gabbr1 Gamma-aminobutyric acid type B receptor subunit 1 4.441e-16 0.47
ANDR_HUMAN AR Androgen receptor 6.661e-16 0.66
MCR_RAT Nr3c2 Mineralocorticoid receptor 1.776e-15 0.66
SIA4A_HUMAN ST3GAL1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 4.441e-15 0.29
GBRG2_HUMAN GABRG2 Gamma-aminobutyric acid receptor subunit gamma-2 4.885e-15 0.49
NMDE2_HUMAN GRIN2B Glutamate receptor ionotropic, NMDA 2B 6.217e-15 0.39
NMDZ1_HUMAN GRIN1 Glutamate receptor ionotropic, NMDA 1 6.661e-15 0.39
REST_BORBU resT Telomere resolvase ResT 8.882e-15 0.37
NTCP_HUMAN SLC10A1 Sodium/bile acid cotransporter 1.976e-14 0.31
ERG2_YEAST ERG2 C-8 sterol isomerase 7.258e-13 0.40
CAH4_BOVIN CA4 Carbonic anhydrase 4 1.303e-12 0.32
FABPL_RAT Fabp1 Fatty acid-binding protein, liver 1.593e-12 0.40
S22A1_HUMAN SLC22A1 Solute carrier family 22 member 1 9.335e-12 0.43
PRGR_RABIT PGR Progesterone receptor 4.779e-11 0.66
GBRB3_HUMAN GABRB3 Gamma-aminobutyric acid receptor subunit beta-3 2.143e-10 0.47
CP19A_HUMAN CYP19A1 Aromatase 2.278e-10 0.66
CP17A_HUMAN CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase 6.807e-10 0.48
LICH_HUMAN LIPA Lysosomal acid lipase/cholesteryl ester hydrolase 5.398e-09 0.32
AT12A_HUMAN ATP12A Potassium-transporting ATPase alpha chain 2 1.291e-07 0.28
DPOLB_RAT Polb DNA polymerase beta 1.942e-07 0.36
CP17A_RAT Cyp17a1 Steroid 17-alpha-hydroxylase/17,20 lyase 1.017e-06 0.31
DHI2_HUMAN HSD11B2 Corticosteroid 11-beta-dehydrogenase isozyme 2 1.686e-06 0.31
TAT_HV112 tat Protein Tat 2.029e-06 0.28
NPCL1_HUMAN NPC1L1 NPC1-like intracellular cholesterol transporter 1 6.935e-06 0.29
GBRA4_RAT Gabra4 Gamma-aminobutyric acid receptor subunit alpha-4 8.827e-06 0.29

Ioflupane_I-123

SC6A3_RAT Slc6a3 Sodium-dependent dopamine transporter 2.516e-189 0.83
Q9WTR4_RAT Slc6a2 Transporter 8.245e-184 0.83
SC6A4_MACMU SLC6A4 Sodium-dependent serotonin transporter 1.689e-129 0.49
Q7JHP9_MACMU SLC6A3 Transporter 6.429e-129 0.49
SC6A4_RAT Slc6a4 Sodium-dependent serotonin transporter 3.656e-116 0.83
SC6A3_MACFA SLC6A3 Sodium-dependent dopamine transporter 1.122e-110 0.65
SC6A3_BOVIN SLC6A3 Sodium-dependent dopamine transporter 2.815e-104 0.54
SC6A3_HUMAN SLC6A3 Sodium-dependent dopamine transporter 6.469e-102 0.83
SC6A4_HUMAN SLC6A4 Sodium-dependent serotonin transporter 6.485e-55 0.78
SC6A2_HUMAN SLC6A2 Sodium-dependent noradrenaline transporter 2.754e-48 0.78
ACHA9_RAT Chrna9 Neuronal acetylcholine receptor subunit alpha-9 4.407e-44 0.38
F1LNR9_RAT Slc6a2 Transporter 2.23e-36 0.31
ACHA2_RAT Chrna2 Neuronal acetylcholine receptor subunit alpha-2 2.66e-12 0.42
Q98UH1_DANRE oprm1 Mu opioid receptor-like OR2 1.754e-11 0.31
ITA5_HUMAN ITGA5 Integrin alpha-5 6.731e-11 0.48
ACM1_RAT Chrm1 Muscarinic acetylcholine receptor M1 7.62e-11 0.49
ACHA6_RAT Chrna6 Neuronal acetylcholine receptor subunit alpha-6 9.089e-11 0.30
Q8WSF8_APLCA Soluble acetylcholine receptor 2.265e-09 0.30
ACHA3_RAT Chrna3 Neuronal acetylcholine receptor subunit alpha-3 2.333e-08 0.42
ACHB4_RAT Chrnb4 Neuronal acetylcholine receptor subunit beta-4 2.447e-08 0.42
ACHG_HUMAN CHRNG Acetylcholine receptor subunit gamma 2.325e-07 0.42
ACHB_HUMAN CHRNB1 Acetylcholine receptor subunit beta 3.842e-07 0.42
ACHD_HUMAN CHRND Acetylcholine receptor subunit delta 5.259e-07 0.42
ACHA3_HUMAN CHRNA3 Neuronal acetylcholine receptor subunit alpha-3 1.26e-06 0.48
ACHB4_HUMAN CHRNB4 Neuronal acetylcholine receptor subunit beta-4 2.584e-06 0.48
ACHA_HUMAN CHRNA1 Acetylcholine receptor subunit alpha 3.65e-06 0.42

Ethyl_biscoumacetate

VKOR1_RAT Vkorc1 Vitamin K epoxide reductase complex subunit 1 1.089e-163 0.61
NQO1_HUMAN NQO1 NAD(P)H dehydrogenase [quinone] 1 1.414e-107 0.76
NQO1_RAT Nqo1 NAD(P)H dehydrogenase [quinone] 1 3.847e-61 0.49
SIAT1_RAT St6gal1 Beta-galactoside alpha-2,6-sialyltransferase 1 1.07e-49 0.32
FAB1_MYCTU kasA 3-oxoacyl-[acyl-carrier-protein] synthase 1 7.528e-39 0.31
PIN4_HUMAN PIN4 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 3.56e-37 0.29
CREB1_HUMAN CREB1 Cyclic AMP-responsive element-binding protein 1 5.933e-33 0.33
Q66HS9_RAT Slc16a7 Monocarboxylate transporter 2 2.203e-29 0.36
TOP2A_HUMAN TOP2A DNA topoisomerase 2-alpha 7.217e-25 0.44
SIAT6_RAT St3gal3 CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase 1.535e-24 0.30
PB1_HUMAN PBRM1 Protein polybromo-1 5.68e-23 0.31
PCSK7_HUMAN PCSK7 Proprotein convertase subtilisin/kexin type 7 7.259e-22 0.49
HST2_YEAST HST2 NAD-dependent protein deacetylase HST2 1.571e-21 0.34
CEL_BOVIN CEL Bile salt-activated lipase 1.28e-20 0.30
Q39829_SOYBN Lipoxygenase 2.588e-20 0.32
VKOR1_BOVIN VKORC1 Vitamin K epoxide reductase complex subunit 1 1.193e-19 0.31
TBA_TRYCR Tubulin alpha chain 5.19e-19 0.30
CEL2A_RAT Cela2a Chymotrypsin-like elastase family member 2A 7.502e-18 0.28
P89582_9HIV2 pol Integrase 1.11e-16 0.37
AOFB_RAT Maob Amine oxidase [flavin-containing] B 2.22e-16 0.36
TPIS_TRYCR Triosephosphate isomerase, glycosomal 6.661e-16 0.30
AOFB_HUMAN MAOB Amine oxidase [flavin-containing] B 2.554e-15 0.42
O93874_COCLU 17HSDcl 17beta-hydroxysteroid dehydrogenase 6.328e-15 0.33
AOFA_RAT Maoa Amine oxidase [flavin-containing] A 2.554e-14 0.36
BCAT1_HUMAN BCAT1 Branched-chain-amino-acid aminotransferase, cytosolic 8.726e-14 0.31
CLAT_RAT Chat Choline O-acetyltransferase 2.293e-13 0.29
SO1A4_RAT Slco1a4 Solute carrier organic anion transporter family member 1A4 2.601e-13 0.29
Q05BA5_MOUSE Ncoa3 Nuclear receptor coactivator 3.217e-12 0.30
SIAT1_HUMAN ST6GAL1 Beta-galactoside alpha-2,6-sialyltransferase 1 6.096e-12 0.32
GPR55_HUMAN GPR55 G-protein coupled receptor 55 6.701e-12 0.34
Q79MP6_PSEAI blaIMP-1 Beta-lactamase 1.326e-11 0.31
AL1A3_HUMAN ALDH1A3 Aldehyde dehydrogenase family 1 member A3 5.24e-11 0.30
IMDH_CRYPV Inosine-5'-monophosphate dehydrogenase 1.266e-10 0.30
AK1C1_HUMAN AKR1C1 Aldo-keto reductase family 1 member C1 2.781e-10 0.36
PRIO_HUMAN PRNP Major prion protein 1.131e-09 0.36
Q72874_9HIV1 pol Pol polyprotein 1.278e-09 0.61
KAT2A_HUMAN KAT2A Histone acetyltransferase KAT2A 1.983e-09 0.32
PPBI_HUMAN ALPI Intestinal-type alkaline phosphatase 3.448e-09 0.35
NMT_CANAL NMT1 Glycylpeptide N-tetradecanoyltransferase 4.478e-09 0.29
NMT_PLAF7 Glycylpeptide N-tetradecanoyltransferase 5.88e-09 0.44
A0A072ZLE6_PSEAI mvfR LysR family transcriptional regulator 7.102e-09 0.31
STXA_SHIDY stxA Shiga toxin subunit A 2.572e-08 0.29
GBRB1_HUMAN GABRB1 Gamma-aminobutyric acid receptor subunit beta-1 3.032e-08 0.29
Q4U254_9ENTO protease Protease 3.148e-08 0.35
AOFA_HUMAN MAOA Amine oxidase [flavin-containing] A 3.564e-08 0.37
MIF_HUMAN MIF Macrophage migration inhibitory factor 8.315e-08 0.38
CAH15_MOUSE Ca15 Carbonic anhydrase 15 8.318e-08 0.34
CP1A2_HUMAN CYP1A2 Cytochrome P450 1A2 1.1e-07 0.44
SMAD3_HUMAN SMAD3 Mothers against decapentaplegic homolog 3 2.68e-07 0.28
EPHA4_MOUSE Epha4 Ephrin type-A receptor 4 2.907e-07 0.33
DHB3_HUMAN HSD17B3 Testosterone 17-beta-dehydrogenase 3 3.62e-07 0.34
ALDH2_HUMAN ALDH2 Aldehyde dehydrogenase, mitochondrial 3.89e-07 0.34
PPID_HUMAN PPID Peptidyl-prolyl cis-trans isomerase D 4.339e-07 0.29
GPR18_HUMAN GPR18 N-arachidonyl glycine receptor 8.63e-07 0.31
PTN1_HUMAN PTPN1 Tyrosine-protein phosphatase non-receptor type 1 9.37e-07 0.34
LOX5_HUMAN ALOX5 Arachidonate 5-lipoxygenase 1.068e-06 0.34
ALF_MYCTU fba Fructose-bisphosphate aldolase 1.219e-06 0.30
CELA1_HUMAN CELA1 Chymotrypsin-like elastase family member 1 1.504e-06 0.29
TNR6_RAT Fas Tumor necrosis factor receptor superfamily member 6 1.698e-06 0.28
TNKS1_HUMAN TNKS Poly [ADP-ribose] polymerase tankyrase-1 2.388e-06 0.43
AOFB_BOVIN MAOB Amine oxidase [flavin-containing] B 3.118e-06 0.31
CCR6_HUMAN CCR6 C-C chemokine receptor type 6 4.823e-06 0.30
TS1R1_HUMAN TAS1R1 Taste receptor type 1 member 1 5.091e-06 0.28
PGH1_SHEEP PTGS1 Prostaglandin G/H synthase 1 5.9e-06 0.31
SENP7_HUMAN SENP7 Sentrin-specific protease 7 6.372e-06 0.41
S22A6_HUMAN SLC22A6 Solute carrier family 22 member 6 6.677e-06 0.36
BIRC5_HUMAN BIRC5 Baculoviral IAP repeat-containing protein 5 9.486e-06 0.37

Formestane

CP19A_HUMAN CYP19A1 Aromatase 1.101e-155 0.72
Q9GRG7_9TRYP g6pd Glucose-6-phosphate 1-dehydrogenase 1.172e-73 0.48
CBG_HUMAN SERPINA6 Corticosteroid-binding globulin 4.562e-64 0.48
G6PD_HUMAN G6PD Glucose-6-phosphate 1-dehydrogenase 6.863e-56 0.48
SHBG_HUMAN SHBG Sex hormone-binding globulin 1.359e-55 0.52
NR1I3_MOUSE Nr1i3 Nuclear receptor subfamily 1 group I member 3 3.498e-50 0.47
S5A2_HUMAN SRD5A2 3-oxo-5-alpha-steroid 4-dehydrogenase 2 1.127e-48 0.46
DHB3_RAT Hsd17b3 Testosterone 17-beta-dehydrogenase 3 2.542e-47 0.48
DHB3_HUMAN HSD17B3 Testosterone 17-beta-dehydrogenase 3 8.125e-39 0.48
SO1A1_RAT Slco1a1 Solute carrier organic anion transporter family member 1A1 2.621e-33 0.42
Q690N0_BOVIN PGR Progesterone receptor 4.698e-33 0.46
ST1E1_BOVIN SULT1E1 Sulfotransferase 1E1 4.15e-30 0.37
S22A8_RAT Slc22a8 Solute carrier family 22 member 8 3.986e-25 0.40
ANDR_RAT Ar Androgen receptor 3.887e-24 0.47
SHBG_RAT Shbg Sex hormone-binding globulin 4.212e-24 0.30
S5A1_HUMAN SRD5A1 3-oxo-5-alpha-steroid 4-dehydrogenase 1 5.244e-24 0.46
STS_HUMAN STS Steryl-sulfatase 1.669e-22 0.46
GBRA4_RAT Gabra4 Gamma-aminobutyric acid receptor subunit alpha-4 7.058e-22 0.31
DHB1_HUMAN HSD17B1 Estradiol 17-beta-dehydrogenase 1 1.702e-21 0.46
S22A3_RAT Slc22a3 Solute carrier family 22 member 3 3.042e-21 0.34
CP17A_HUMAN CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase 6.275e-19 0.38
AT12A_HUMAN ATP12A Potassium-transporting ATPase alpha chain 2 4.085e-17 0.34
S22A2_RAT Slc22a2 Solute carrier family 22 member 2 1.11e-16 0.36
CP17A_RAT Cyp17a1 Steroid 17-alpha-hydroxylase/17,20 lyase 5.551e-16 0.34
ERG2_YEAST ERG2 C-8 sterol isomerase 1.236e-13 0.38
MRP4_HUMAN ABCC4 Multidrug resistance-associated protein 4 3.032e-13 0.39
FABPL_RAT Fabp1 Fatty acid-binding protein, liver 2.884e-11 0.36
ANDR_MOUSE Ar Androgen receptor 3.497e-11 0.38
3BHS1_HUMAN HSD3B1 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 7.541e-10 0.29
SO1B1_HUMAN SLCO1B1 Solute carrier organic anion transporter family member 1B1 1.492e-08 0.40
S22A3_HUMAN SLC22A3 Solute carrier family 22 member 3 1.179e-07 0.36
GPBAR_HUMAN GPBAR1 G-protein coupled bile acid receptor 1 2.082e-07 0.48
PRGR_RABIT PGR Progesterone receptor 4.676e-07 0.36

Tafluprost

PF2R_BOVIN PTGFR Prostaglandin F2-alpha receptor 3.991e-153 0.63
PF2R_HUMAN PTGFR Prostaglandin F2-alpha receptor 1.926e-110 0.63
PF2R_MOUSE Ptgfr Prostaglandin F2-alpha receptor 1.841e-73 0.46
SO2A1_HUMAN SLCO2A1 Solute carrier organic anion transporter family member 2A1 9.013e-69 0.42
SO2A1_MOUSE Slco2a1 Solute carrier organic anion transporter family member 2A1 7.316e-60 0.42
SO2B1_RAT Slco2b1 Solute carrier organic anion transporter family member 2B1 1.017e-33 0.42
PD2R_HUMAN PTGDR Prostaglandin D2 receptor 8.939e-29 0.42
PE2R3_HUMAN PTGER3 Prostaglandin E2 receptor EP3 subtype 4.605e-23 0.56
TA2R_HUMAN TBXA2R Thromboxane A2 receptor 2.029e-18 0.56
PE2R2_HUMAN PTGER2 Prostaglandin E2 receptor EP2 subtype 7.245e-18 0.47
PE2R2_MOUSE Ptger2 Prostaglandin E2 receptor EP2 subtype 2.687e-14 0.38
SO2A1_RAT Slco2a1 Solute carrier organic anion transporter family member 2A1 3.003e-13 0.42
PE2R1_MOUSE Ptger1 Prostaglandin E2 receptor EP1 subtype 2.972e-12 0.38
TA2R_RAT Tbxa2r Thromboxane A2 receptor 1.982e-10 0.38
S22A6_MOUSE Slc22a6 Solute carrier family 22 member 6 2.435e-10 0.30
PE2R4_HUMAN PTGER4 Prostaglandin E2 receptor EP4 subtype 1.536e-09 0.42
PI2R_HUMAN PTGIR Prostacyclin receptor 7.625e-09 0.33
PE2R4_MOUSE Ptger4 Prostaglandin E2 receptor EP4 subtype 1.371e-07 0.38
PE2R1_HUMAN PTGER1 Prostaglandin E2 receptor EP1 subtype 1.565e-07 0.56
PE2R3_MOUSE Ptger3 Prostaglandin E2 receptor EP3 subtype 1.594e-06 0.38

Flavone

I3LTK9_PIG CEL Carboxylic ester hydrolase 4.2e-151 0.58
CREB1_HUMAN CREB1 Cyclic AMP-responsive element-binding protein 1 1.744e-93 0.49
SIAT1_RAT St6gal1 Beta-galactoside alpha-2,6-sialyltransferase 1 1.383e-81 0.66
VKOR1_RAT Vkorc1 Vitamin K epoxide reductase complex subunit 1 3.142e-60 0.33
CP1B1_HUMAN CYP1B1 Cytochrome P450 1B1 6.949e-59 0.70
SIAT6_RAT St3gal3 CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase 2.107e-52 0.66
NQO1_HUMAN NQO1 NAD(P)H dehydrogenase [quinone] 1 6.045e-48 0.44
TOP1_RAT Top1 DNA topoisomerase 1 8.534e-47 0.37
NQO1_RAT Nqo1 NAD(P)H dehydrogenase [quinone] 1 3.546e-45 0.36
PTPRS_HUMAN PTPRS Receptor-type tyrosine-protein phosphatase S 5.336e-43 0.47
CP1A1_HUMAN CYP1A1 Cytochrome P450 1A1 3.661e-42 0.58
OPRD_PIG OPRD1 Delta-type opioid receptor 9.952e-40 0.31
VKOR1_BOVIN VKORC1 Vitamin K epoxide reductase complex subunit 1 3.887e-39 0.33
RMLD_MYCTU rmlD dTDP-4-dehydrorhamnose reductase 1.615e-35 0.44
TNKS1_HUMAN TNKS Poly [ADP-ribose] polymerase tankyrase-1 6.391e-34 0.77
ARGI1_RAT Arg1 Arginase-1 4.785e-30 0.37
PRKDC_MOUSE Prkdc DNA-dependent protein kinase catalytic subunit 5.179e-28 0.35
P89582_9HIV2 pol Integrase 6.461e-28 0.33
ALDR_RAT Akr1b1 Aldo-keto reductase family 1 member B1 1.528e-27 0.56
ACES_ELEEL ache Acetylcholinesterase 6.601e-27 0.47
BGLR_RAT Gusb Beta-glucuronidase 2.03e-26 0.42
MRP1_HUMAN ABCC1 Multidrug resistance-associated protein 1 5.652e-25 0.44
ACES_RAT Ache Acetylcholinesterase 1.68e-24 0.41
ISPE_YERPE ispE 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 3.169e-24 0.30
PRKDC_HUMAN PRKDC DNA-dependent protein kinase catalytic subunit 5.653e-24 0.58
CHLE_HORSE BCHE Cholinesterase 5.812e-24 0.47
ALDR_BOVIN AKR1B1 Aldo-keto reductase family 1 member B1 2.87e-21 0.65
SGMR1_HUMAN SIGMAR1 Sigma non-opioid intracellular receptor 1 3.448e-21 0.52
PERL_BOVIN LPO Lactoperoxidase 3.828e-20 0.34
AMY1A_HUMAN AMY1A Alpha-amylase 1 7.953e-20 0.38
AHR_HUMAN AHR Aryl hydrocarbon receptor 1.112e-19 0.63
SIAT1_HUMAN ST6GAL1 Beta-galactoside alpha-2,6-sialyltransferase 1 2.908e-19 0.66
ABCG2_HUMAN ABCG2 Broad substrate specificity ATP-binding cassette transporter ABCG2 6.456e-19 0.63
CEL2A_RAT Cela2a Chymotrypsin-like elastase family member 2A 9.803e-19 0.30
EF1A1_HUMAN EEF1A1 Elongation factor 1-alpha 1 2.898e-18 0.29
EF1A2_HUMAN EEF1A2 Elongation factor 1-alpha 2 2.898e-18 0.29
CALM1_HUMAN CALM1 Calmodulin-1 3.492e-18 0.68
XDH_HUMAN XDH Xanthine dehydrogenase/oxidase 3.394e-17 0.53
MDR1_HUMAN ABCB1 ATP-dependent translocase ABCB1 1.11e-16 0.61
PLGF_HUMAN PGF Placenta growth factor 1.11e-16 0.31
TPIS_TRYCR Triosephosphate isomerase, glycosomal 1.11e-16 0.32
PCSK7_HUMAN PCSK7 Proprotein convertase subtilisin/kexin type 7 2.22e-16 0.36
DPO1_THEAQ polA DNA polymerase I, thermostable 3.331e-16 0.37
LX15B_RAT Alox15b Arachidonate 15-lipoxygenase B 3.331e-16 0.53
PPAC_HUMAN ACP1 Low molecular weight phosphotyrosine protein phosphatase 1.443e-15 0.32
TNKS2_HUMAN TNKS2 Poly [ADP-ribose] polymerase tankyrase-2 2.554e-15 0.77
PGH2_SHEEP PTGS2 Prostaglandin G/H synthase 2 5.662e-15 0.35
KCND3_HUMAN KCND3 Potassium voltage-gated channel subfamily D member 3 5.995e-15 0.37
DRD2_RAT Drd2 D(2) dopamine receptor 8.696e-13 0.51
Q79MP6_PSEAI blaIMP-1 Beta-lactamase 1.136e-12 0.40
Q72874_9HIV1 pol Pol polyprotein 2.321e-12 0.45
Q965D6_PLAFA fabG 3-oxoacyl-acyl-carrier protein reductase 1.05e-11 0.37
TBB2B_BOVIN TUBB2B Tubulin beta-2B chain 1.192e-11 0.33
AOFB_HUMAN MAOB Amine oxidase [flavin-containing] B 1.732e-11 0.77
TERT_HUMAN TERT Telomerase reverse transcriptase 6.887e-11 0.38
DHB3_HUMAN HSD17B3 Testosterone 17-beta-dehydrogenase 3 7.858e-11 0.39
ESR2_RAT Esr2 Estrogen receptor beta 1.214e-10 0.33
CBS_HUMAN CBS Cystathionine beta-synthase 1.336e-10 0.28
S22A6_MOUSE Slc22a6 Solute carrier family 22 member 6 1.517e-10 0.31
CAH3_HUMAN CA3 Carbonic anhydrase 3 1.598e-10 0.33
AK1BA_HUMAN AKR1B10 Aldo-keto reductase family 1 member B10 1.645e-10 0.70
GPR35_MOUSE Gpr35 G-protein coupled receptor 35 1.647e-10 0.28
AOFA_HUMAN MAOA Amine oxidase [flavin-containing] A 2.102e-10 0.47
GGPPS_YEAST BTS1 Geranylgeranyl pyrophosphate synthase 2.317e-10 0.30
STXA_SHIDY stxA Shiga toxin subunit A 4.412e-10 0.36
Q965D7_PLAFA fabZ Beta-hydroxyacyl-ACP dehydratase 8.183e-10 0.37
AOFB_RAT Maob Amine oxidase [flavin-containing] B 1.12e-09 0.35
ESR1_RAT Esr1 Estrogen receptor 1.203e-09 0.33
AK1C1_HUMAN AKR1C1 Aldo-keto reductase family 1 member C1 2.315e-09 0.62
A0A045ISB3_MYCTX ptbB Phosphotyrosine protein phosphatase 3.752e-09 0.33
CP19A_HUMAN CYP19A1 Aromatase 1.047e-08 0.70
DCOR_HUMAN ODC1 Ornithine decarboxylase 1.075e-08 0.33
Q7ZJM1_9HIV1 pol Integrase 2.653e-08 0.53
MRP2_RAT Abcc2 Canalicular multispecific organic anion transporter 1 4.531e-08 0.36
LOX15_RAT Alox15 Arachidonate 15-lipoxygenase 7.033e-08 0.53
ANDR_HUMAN AR Androgen receptor 9.249e-08 0.62
NLRP3_HUMAN NLRP3 NACHT, LRR and PYD domains-containing protein 3 9.936e-08 0.69
PTR1_LEIMA PTR1 Pteridine reductase 1 1.061e-07 0.53
GBRA3_RAT Gabra3 Gamma-aminobutyric acid receptor subunit alpha-3 1.103e-07 0.37
LOX5_RAT Alox5 Arachidonate 5-lipoxygenase 1.153e-07 0.53
GRK6_HUMAN GRK6 G protein-coupled receptor kinase 6 1.27e-07 0.53
CLK1_MOUSE Clk1 Dual specificity protein kinase CLK1 1.282e-07 0.37
DOPO_HUMAN DBH Dopamine beta-hydroxylase 1.324e-07 0.28
AOFA_RAT Maoa Amine oxidase [flavin-containing] A 1.476e-07 0.37
CP1A2_HUMAN CYP1A2 Cytochrome P450 1A2 1.731e-07 0.58
SMAD3_HUMAN SMAD3 Mothers against decapentaplegic homolog 3 1.934e-07 0.29
ALDR_HUMAN AKR1B1 Aldo-keto reductase family 1 member B1 2.058e-07 0.39
CAH13_MOUSE Ca13 Carbonic anhydrase 13 2.356e-07 0.31
BCAT1_HUMAN BCAT1 Branched-chain-amino-acid aminotransferase, cytosolic 2.38e-07 0.30
CAH15_MOUSE Ca15 Carbonic anhydrase 15 2.605e-07 0.33
DPOL_VACCW POL DNA polymerase 3.269e-07 0.36
AA1R_RAT Adora1 Adenosine receptor A1 4.204e-07 0.70
AA1R_BOVIN ADORA1 Adenosine receptor A1 4.921e-07 0.36
Q8T8E9_9TRYP galE UDP-galactose 4-epimerase 5.622e-07 0.28
NR4A2_HUMAN NR4A2 Nuclear receptor subfamily 4 group A member 2 5.74e-07 0.28
C11B1_HUMAN CYP11B1 Cytochrome P450 11B1, mitochondrial 6.002e-07 0.45
ERCC5_HUMAN ERCC5 DNA repair protein complementing XP-G cells 8.064e-07 0.32
TIM23_YEAST TIM23 Mitochondrial import inner membrane translocase subunit TIM23 1.023e-06 0.34
CD5R1_HUMAN CDK5R1 Cyclin-dependent kinase 5 activator 1 1.829e-06 0.37
ALDH2_HUMAN ALDH2 Aldehyde dehydrogenase, mitochondrial 3.101e-06 0.39
PGH2_MOUSE Ptgs2 Prostaglandin G/H synthase 2 3.262e-06 0.65
KDM4E_HUMAN KDM4E Lysine-specific demethylase 4E 3.317e-06 0.53
P90584_PLAFA Pfmrk MO15-related protein kinase Pfmrk 4.005e-06 0.42
SENP7_HUMAN SENP7 Sentrin-specific protease 7 4.545e-06 0.53
CHLE_HUMAN BCHE Cholinesterase 5.101e-06 0.34
STS_HUMAN STS Steryl-sulfatase 5.469e-06 0.56
SL9A1_HUMAN SLC9A1 Sodium/hydrogen exchanger 1 5.717e-06 0.35
CATL2_HUMAN CTSV Cathepsin L2 6.095e-06 0.41
FEN1_HUMAN FEN1 Flap endonuclease 1 6.137e-06 0.32
TTHY_HUMAN TTR Transthyretin 6.56e-06 0.42
GPR35_HUMAN GPR35 G-protein coupled receptor 35 6.677e-06 0.37
TCMO_POPKI CYP73A16 Trans-cinnamate 4-monooxygenase 6.965e-06 0.32
PSB8_HUMAN PSMB8 Proteasome subunit beta type-8 8.248e-06 0.32
PA24A_HUMAN PLA2G4A Cytosolic phospholipase A2 9.474e-06 0.86

Unoprostone

PF2R_BOVIN PTGFR Prostaglandin F2-alpha receptor 1.669e-116 0.57
PF2R_HUMAN PTGFR Prostaglandin F2-alpha receptor 4.996e-113 0.57
SO2A1_HUMAN SLCO2A1 Solute carrier organic anion transporter family member 2A1 5.719e-94 0.57
SO2A1_MOUSE Slco2a1 Solute carrier organic anion transporter family member 2A1 2.299e-82 0.57
PF2R_MOUSE Ptgfr Prostaglandin F2-alpha receptor 4.802e-78 0.57
SO2B1_RAT Slco2b1 Solute carrier organic anion transporter family member 2B1 1.969e-73 0.57
TRPV2_RAT Trpv2 Transient receptor potential cation channel subfamily V member 2 3.042e-60 0.39
PD2R_HUMAN PTGDR Prostaglandin D2 receptor 8.966e-60 0.57
LPAR1_MOUSE Lpar1 Lysophosphatidic acid receptor 1 3.366e-46 0.31
TA2R_HUMAN TBXA2R Thromboxane A2 receptor 1.871e-43 0.57
Q6UB75_PIG Group VII phospholipase A2 4.239e-41 0.33
OXER1_HUMAN OXER1 Oxoeicosanoid receptor 1 1.602e-39 0.51
SPTC2_HUMAN SPTLC2 Serine palmitoyltransferase 2 2.175e-39 0.35
CERT_HUMAN CERT1 Ceramide transfer protein 1.071e-38 0.31
LPAR4_HUMAN LPAR4 Lysophosphatidic acid receptor 4 2.524e-38 0.29
PE2R2_MOUSE Ptger2 Prostaglandin E2 receptor EP2 subtype 3.85e-36 0.42
LPAR4_MOUSE Lpar4 Lysophosphatidic acid receptor 4 3.875e-36 0.29
SPTC1_HUMAN SPTLC1 Serine palmitoyltransferase 1 3.875e-36 0.29
ACER2_HUMAN ACER2 Alkaline ceramidase 2 7.62e-36 0.28
PE2R2_HUMAN PTGER2 Prostaglandin E2 receptor EP2 subtype 1.822e-35 0.51
PLCG1_BOVIN PLCG1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 9.54e-31 0.30
SO2A1_RAT Slco2a1 Solute carrier organic anion transporter family member 2A1 2.318e-30 0.57
PE2R1_MOUSE Ptger1 Prostaglandin E2 receptor EP1 subtype 9.783e-29 0.42
LPAR6_HUMAN LPAR6 Lysophosphatidic acid receptor 6 2.847e-23 0.29
POLI_MOUSE Poli DNA polymerase iota 4.185e-23 0.28
PE2R3_HUMAN PTGER3 Prostaglandin E2 receptor EP3 subtype 9.725e-23 0.57
PA24B_HUMAN PLA2G4B Cytosolic phospholipase A2 beta 2.114e-22 0.32
CNR1_RAT Cnr1 Cannabinoid receptor 1 3.531e-22 0.45
Q9MYX2_PIG CPT1 Carnitine palmitoyl transferase I liver isoform 4.554e-19 0.29
CNR2_MOUSE Cnr2 Cannabinoid receptor 2 1.12e-18 0.40
PI2R_HUMAN PTGIR Prostacyclin receptor 4.506e-18 0.42
AMD_HUMAN PAM Peptidyl-glycine alpha-amidating monooxygenase 4.77e-18 0.29
PE2R4_MOUSE Ptger4 Prostaglandin E2 receptor EP4 subtype 1.031e-17 0.42
PE2R3_MOUSE Ptger3 Prostaglandin E2 receptor EP3 subtype 1.034e-17 0.42
CNR1_MOUSE Cnr1 Cannabinoid receptor 1 1.11e-16 0.44
FAAH1_HUMAN FAAH Fatty-acid amide hydrolase 1 1.11e-16 0.45
FAAH1_RAT Faah Fatty-acid amide hydrolase 1 4.441e-16 0.36
LPAR2_HUMAN LPAR2 Lysophosphatidic acid receptor 2 6.661e-16 0.33
LOX15_PIG ALOX15 Arachidonate 15-lipoxygenase 1.887e-15 0.35
FABPH_HUMAN FABP3 Fatty acid-binding protein, heart 3.442e-15 0.51
POLH_HUMAN POLH DNA polymerase eta 5.662e-15 0.28
PE2R1_HUMAN PTGER1 Prostaglandin E2 receptor EP1 subtype 2.565e-14 0.57
S22A6_MOUSE Slc22a6 Solute carrier family 22 member 6 3.653e-14 0.42
PRP19_YEAST PRP19 Pre-mRNA-processing factor 19 3.852e-14 0.31
TA2R_RAT Tbxa2r Thromboxane A2 receptor 9.159e-14 0.43
Q8HY88_BOVIN KCNK2 Potassium channel subfamily K member 2 2.496e-13 0.33
PE2R4_HUMAN PTGER4 Prostaglandin E2 receptor EP4 subtype 4.58e-13 0.57
Q95214_RABIT ACAT Acyl-CoA:cholesterol acyltransferase 9.048e-13 0.33
FAAH1_MOUSE Faah Fatty-acid amide hydrolase 1 1.867e-12 0.35
REST_BORBU resT Telomere resolvase ResT 3.82e-12 0.30
PA2GX_HUMAN PLA2G10 Group 10 secretory phospholipase A2 6.047e-12 0.32
LPAR3_HUMAN LPAR3 Lysophosphatidic acid receptor 3 6.688e-12 0.31
HMDH_HUMAN HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1.035e-11 0.39
POLK_HUMAN POLK DNA polymerase kappa 1.17e-11 0.28
MGLL_RAT Mgll Monoglyceride lipase 1.442e-11 0.34
PA2GC_HUMAN PLA2G2C Putative inactive group IIC secretory phospholipase A2 2.335e-11 0.33
LPXC_AQUAE lpxC UDP-3-O-acyl-N-acetylglucosamine deacetylase 2.665e-11 0.30
PE2R2_RAT Ptger2 Prostaglandin E2 receptor EP2 subtype 3.234e-10 0.42
HYES_HUMAN EPHX2 Bifunctional epoxide hydrolase 2 1.033e-09 0.45
EST1_RABIT Liver carboxylesterase 1 1.586e-09 0.29
LPAR1_HUMAN LPAR1 Lysophosphatidic acid receptor 1 1.731e-09 0.33
LASR_PSEAE lasR Transcriptional activator protein LasR 4.799e-09 0.33
EST1_HUMAN CES1 Liver carboxylesterase 1 1.575e-08 0.35
Q9RMS5_PSEAI phzR LuxR family transcriptional regulator 1.881e-08 0.33
GPR18_HUMAN GPR18 N-arachidonyl glycine receptor 3.464e-08 0.38
S22A8_HUMAN SLC22A8 Solute carrier family 22 member 8 5.109e-08 0.40
S22A6_RAT Slc22a6 Solute carrier family 22 member 6 1.149e-07 0.28
CNR1_HUMAN CNR1 Cannabinoid receptor 1 4.166e-07 0.48
GLCM_MOUSE Gba Lysosomal acid glucosylceramidase 4.312e-07 0.32
PE2R4_RAT Ptger4 Prostaglandin E2 receptor EP4 subtype 6.847e-07 0.42
KPCA_BOVIN PRKCA Protein kinase C alpha type 1.078e-06 0.30
BGAL_HUMAN GLB1 Beta-galactosidase 1.198e-06 0.28
S22A6_HUMAN SLC22A6 Solute carrier family 22 member 6 1.722e-06 0.40
MRP2_RAT Abcc2 Canalicular multispecific organic anion transporter 1 1.841e-06 0.28
MPIP2_MOUSE Cdc25b M-phase inducer phosphatase 2 2.444e-06 0.31
PPARG_HUMAN PPARG Peroxisome proliferator-activated receptor gamma 3.872e-06 0.51
TLR2_HUMAN TLR2 Toll-like receptor 2 4.285e-06 0.40
THAS_HUMAN TBXAS1 Thromboxane-A synthase 8.223e-06 0.40

Ibuproxam

AMPN_PIG ANPEP Aminopeptidase N 1.562e-108 0.40
AMP1_PLAFQ M1 family aminopeptidase 1.175e-105 0.40
FCER2_HUMAN FCER2 Low affinity immunoglobulin epsilon Fc receptor 3.16e-99 0.37
HDAC1_RAT Hdac1 Histone deacetylase 1 6.001e-93 0.34
NEP_RABIT MME Neprilysin 5.801e-80 0.42
NEP_MOUSE Mme Neprilysin 1.887e-72 0.36
VM1B1_BOTAS Snake venom metalloproteinase BaP1 1.308e-64 0.40
NEP_RAT Mme Neprilysin 4.476e-58 0.39
NEP_HUMAN MME Neprilysin 6.43e-48 0.39
AMPN_HUMAN ANPEP Aminopeptidase N 4.444e-46 0.40
AMPN_MOUSE Anpep Aminopeptidase N 8.791e-46 0.33
ACE2_HUMAN ACE2 Angiotensin-converting enzyme 2 1.057e-44 0.35
MMP8_HUMAN MMP8 Neutrophil collagenase 1.508e-43 0.38
AMPB_RAT Rnpep Aminopeptidase B 3.323e-41 0.33
AMPB_MOUSE Rnpep Aminopeptidase B 3.568e-41 0.33
AMPL_BOVIN LAP3 Cytosol aminopeptidase 3.568e-41 0.33
AMPX_VIBPR Bacterial leucyl aminopeptidase 6.319e-41 0.36
Q99P97_RAT Histone deacetylase 6 2.281e-40 0.32
GPR88_MOUSE Gpr88 Probable G-protein coupled receptor 88 1.102e-37 0.30
CSK_HUMAN CSK Tyrosine-protein kinase CSK 3.585e-37 0.57
MMP1_HUMAN MMP1 Interstitial collagenase 5.048e-37 0.47
GLUT4_HUMAN SLC2A4 Solute carrier family 2, facilitated glucose transporter member 4 1.987e-36 0.30
LEF_BACAN lef Lethal factor 5.687e-36 0.33
THER_BACTH npr Thermolysin 6.234e-34 0.39
Q79MP6_PSEAI blaIMP-1 Beta-lactamase 1.964e-33 0.35
DNPEP_HUMAN DNPEP Aspartyl aminopeptidase 2.192e-33 0.34
MMP3_HUMAN MMP3 Stromelysin-1 5.271e-33 0.38
S15A1_HUMAN SLC15A1 Solute carrier family 15 member 1 1.468e-32 0.34
MMP9_HUMAN MMP9 Matrix metalloproteinase-9 1.778e-32 0.47
MMP2_HUMAN MMP2 72 kDa type IV collagenase 1.538e-31 0.47
TAAR1_MACMU TAAR1 Trace amine-associated receptor 1 1.292e-30 0.32
MMP12_MOUSE Mmp12 Macrophage metalloelastase 1.108e-29 0.29
S22AK_MOUSE Slc22a20 Solute carrier family 22 member 20 4.236e-29 0.66
ACE_MOUSE Ace Angiotensin-converting enzyme 9.92e-29 0.32
ACE_HUMAN ACE Angiotensin-converting enzyme 3.591e-28 0.35
CBPA1_HUMAN CPA1 Carboxypeptidase A1 8.058e-28 0.33
MMP8_RAT Mmp8 Neutrophil collagenase 3.322e-27 0.31
S15A2_RAT Slc15a2 Solute carrier family 15 member 2 1.457e-26 0.33
MMP7_HUMAN MMP7 Matrilysin 1.451e-25 0.37
Q94F81_MAIZE hda106 HD2 type histone deacetylase HDA106 2.777e-25 0.33
SCYD_MAGO7 SDH1 Scytalone dehydratase 2.655e-23 0.30
FPR1_HUMAN FPR1 fMet-Leu-Phe receptor 3.976e-23 0.33
AMPB_HUMAN RNPEP Aminopeptidase B 1.072e-21 0.31
S22A6_MOUSE Slc22a6 Solute carrier family 22 member 6 1.361e-21 0.66
NK1R_RAT Tacr1 Substance-P receptor 2.733e-21 0.33
SYYC_HUMAN YARS1 Tyrosine--tRNA ligase, cytoplasmic 3.271e-21 0.31
LCAP_RAT Lnpep Leucyl-cystinyl aminopeptidase 1.708e-20 0.33
NEP_PIG MME Neprilysin 9.381e-20 0.30
GPR88_HUMAN GPR88 Probable G-protein coupled receptor 88 1.796e-19 0.36
TRPV1_RAT Trpv1 Transient receptor potential cation channel subfamily V member 1 1.986e-19 0.38
C6ARS9_RHILS lpxC UDP-3-O-acyl-N-acetylglucosamine deacetylase 2.322e-19 0.31
CAN2_BOVIN CAPN2 Calpain-2 catalytic subunit 4.879e-18 0.29
CBPA3_HUMAN CPA3 Mast cell carboxypeptidase A 4.879e-18 0.29
E2RFF5_CANLF ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif 4 6.785e-18 0.28
Q39829_SOYBN Lipoxygenase 8.104e-18 0.28
S22A6_RAT Slc22a6 Solute carrier family 22 member 6 1.11e-16 0.66
AMPL_HUMAN LAP3 Cytosol aminopeptidase 7.772e-16 0.34
ACACB_HUMAN ACACB Acetyl-CoA carboxylase 2 2.776e-15 0.38
LPXC_ECOLI lpxC UDP-3-O-acyl-N-acetylglucosamine deacetylase 6.439e-15 0.35
ACE_RAT Ace Angiotensin-converting enzyme 9.659e-15 0.34
PSA_HUMAN NPEPPS Puromycin-sensitive aminopeptidase 2.875e-14 0.33
LPXC_PSEAE lpxC UDP-3-O-acyl-N-acetylglucosamine deacetylase 5.229e-14 0.42
ALBU_BOVIN ALB Serum albumin 5.762e-14 0.66
MMP14_HUMAN MMP14 Matrix metalloproteinase-14 1.011e-13 0.37
LOX5_RAT Alox5 Arachidonate 5-lipoxygenase 1.381e-13 0.61
PGH2_BOVIN PTGS2 Prostaglandin G/H synthase 2 1.903e-13 0.66
MMP16_HUMAN MMP16 Matrix metalloproteinase-16 4.031e-13 0.36
G3V673_RAT Adamts5 A disintegrin-like and metallopeptidase (Reprolysin type) with thrombospondin type 1 motif, 5 (Aggrecanase-2) 4.967e-13 0.28
ENPP2_MOUSE Enpp2 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 1.938e-12 0.30
GSP_CRIFA GSP Glutathionylspermidine synthase 4.628e-12 0.29
MMP9_RAT Mmp9 Matrix metalloproteinase-9 5.6e-12 0.31
CBPA1_BOVIN CPA1 Carboxypeptidase A1 6.095e-12 0.39
VMAT2_MOUSE Slc18a2 Synaptic vesicular amine transporter 6.966e-12 0.29
COLA_CLOPE colA Collagenase ColA 8.187e-12 0.33
HDAC8_HUMAN HDAC8 Histone deacetylase 8 1.24e-11 0.36
HDAC5_HUMAN HDAC5 Histone deacetylase 5 1.481e-11 0.38
LOX15_RAT Alox15 Arachidonate 15-lipoxygenase 1.823e-11 0.50
HDAC7_HUMAN HDAC7 Histone deacetylase 7 1.968e-11 0.38
ADRB2_RAT Adrb2 Beta-2 adrenergic receptor 3.696e-11 0.30
AMPL_PIG LAP3 Cytosol aminopeptidase 4.159e-11 0.35
PGH1_SHEEP PTGS1 Prostaglandin G/H synthase 1 2.196e-10 0.66
S22A6_HUMAN SLC22A6 Solute carrier family 22 member 6 4.333e-10 0.66
IL8_HUMAN CXCL8 Interleukin-8 7.261e-10 0.66
CAN1_PIG CAPN1 Calpain-1 catalytic subunit 7.44e-10 0.34
SOAT1_RAT Soat1 Sterol O-acyltransferase 1 1.168e-09 0.33
PGH1_BOVIN PTGS1 Prostaglandin G/H synthase 1 1.181e-09 0.66
AMD_HUMAN PAM Peptidyl-glycine alpha-amidating monooxygenase 1.206e-09 0.30
CAN2_HUMAN CAPN2 Calpain-2 catalytic subunit 1.218e-09 0.30
DXR_ECOLI dxr 1-deoxy-D-xylulose 5-phosphate reductoisomerase 2.56e-09 0.36
ELAS_PSEAE lasB Elastase 2.599e-09 0.30
PSBA_MARPO psbA Photosystem II protein D1 3.598e-09 0.29
ACE_RABIT ACE Angiotensin-converting enzyme 3.865e-09 0.34
ADA17_HUMAN ADAM17 Disintegrin and metalloproteinase domain-containing protein 17 5.939e-09 0.47
BMP1_HUMAN BMP1 Bone morphogenetic protein 1 6.291e-09 0.35
ANF_HUMAN NPPA Natriuretic peptides A 7.102e-09 0.31
CAN1_HUMAN CAPN1 Calpain-1 catalytic subunit 1.135e-08 0.33
CATL1_BOVIN CTSL Cathepsin L1 1.199e-08 0.29
CATK_RABIT CTSK Cathepsin K 1.689e-08 0.38
MMP13_RAT Mmp13 Collagenase 3 1.881e-08 0.33
HDAC6_HUMAN HDAC6 Histone deacetylase 6 2.492e-08 0.36
MMP13_HUMAN MMP13 Collagenase 3 5.118e-08 0.37
VMAT2_HUMAN SLC18A2 Synaptic vesicular amine transporter 8.352e-08 0.29
ACPS_BACSU acpS Holo-[acyl-carrier-protein] synthase 1.188e-07 0.31
TRPV1_HUMAN TRPV1 Transient receptor potential cation channel subfamily V member 1 2.275e-07 0.52
MMP12_HUMAN MMP12 Macrophage metalloelastase 4.036e-07 0.36
AL5AP_HUMAN ALOX5AP Arachidonate 5-lipoxygenase-activating protein 4.344e-07 0.37
ESR2_RAT Esr2 Estrogen receptor beta 4.971e-07 0.29
ECE1_HUMAN ECE1 Endothelin-converting enzyme 1 4.996e-07 0.39
S1PR5_HUMAN S1PR5 Sphingosine 1-phosphate receptor 5 5.056e-07 0.32
MMEL1_HUMAN MMEL1 Membrane metallo-endopeptidase-like 1 8.97e-07 0.31
LKHA4_HUMAN LTA4H Leukotriene A-4 hydrolase 1.035e-06 0.39
FOLH1_HUMAN FOLH1 Glutamate carboxypeptidase 2 1.121e-06 0.39
MMP10_HUMAN MMP10 Stromelysin-2 1.19e-06 0.30
MMP17_HUMAN MMP17 Matrix metalloproteinase-17 1.52e-06 0.31
CATB_BOVIN CTSB Cathepsin B 1.577e-06 0.30
LKHA4_CAVPO LTA4H Leukotriene A-4 hydrolase 1.597e-06 0.31
MDM4_HUMAN MDM4 Protein Mdm4 2.386e-06 0.29
CAH4_BOVIN CA4 Carbonic anhydrase 4 2.388e-06 0.33
CA2D1_MOUSE Cacna2d1 Voltage-dependent calcium channel subunit alpha-2/delta-1 2.941e-06 0.28
Q8IL11_PLAF7 M17 leucyl aminopeptidase 3.075e-06 0.33
PAPA1_CARPA Papain 3.406e-06 0.30
S1PR4_HUMAN S1PR4 Sphingosine 1-phosphate receptor 4 3.436e-06 0.32
NALD2_HUMAN NAALAD2 N-acetylated-alpha-linked acidic dipeptidase 2 5.557e-06 0.29
SCN2A_RAT Scn2a Sodium channel protein type 2 subunit alpha 5.859e-06 0.32
PGH2_HUMAN PTGS2 Prostaglandin G/H synthase 2 8.181e-06 0.66
BLA2_BACCE blm Metallo-beta-lactamase type 2 8.279e-06 0.28

Linaclotide

V2R_PIG AVPR2 Vasopressin V2 receptor 1.898e-106 0.34
HDAC5_MOUSE Hdac5 Histone deacetylase 5 1.269e-54 0.33
V2R_BOVIN AVPR2 Vasopressin V2 receptor 4.856e-54 0.35
GRB2_HUMAN GRB2 Growth factor receptor-bound protein 2 4.834e-49 0.44
Q5D7U5_CHICK OXTR Oxytocin-like receptor 8.096e-49 0.39
EDNRA_PIG EDNRA Endothelin-1 receptor 1.246e-47 0.36
HDAC8_MOUSE Hdac8 Histone deacetylase 8 1.355e-46 0.31
V1BR_HUMAN AVPR1B Vasopressin V1b receptor 1.688e-46 0.43
OPRD_RAT Oprd1 Delta-type opioid receptor 1.727e-44 0.45
OST48_HUMAN DDOST Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit 4.182e-44 0.32
OXYR_HUMAN OXTR Oxytocin receptor 4.204e-44 0.52
MC4R_MOUSE Mc4r Melanocortin receptor 4 6.531e-42 0.44
OPRM_RAT Oprm1 Mu-type opioid receptor 1.67e-40 0.45
CADH2_HUMAN CDH2 Cadherin-2 8.465e-40 0.32
ITA3_HUMAN ITGA3 Integrin alpha-3 9.155e-39 0.47
OPRD_MOUSE Oprd1 Delta-type opioid receptor 1.138e-37 0.45
CXCR4_HUMAN CXCR4 C-X-C chemokine receptor type 4 1.357e-37 0.39
SSR5_RAT Sstr5 Somatostatin receptor type 5 1.323e-36 0.30
OXYR_RAT Oxtr Oxytocin receptor 3.17e-35 0.47
MC3R_MOUSE Mc3r Melanocortin receptor 3 6.527e-33 0.44
ITB3_HUMAN ITGB3 Integrin beta-3 3.526e-32 0.39
MEN1_HUMAN MEN1 Menin 1.696e-30 0.37
OPRM_CAVPO OPRM1 Mu-type opioid receptor 1.872e-29 0.45
ITA2B_HUMAN ITGA2B Integrin alpha-IIb 3.461e-29 0.38
V2R_HUMAN AVPR2 Vasopressin V2 receptor 3.067e-28 0.43
V1AR_HUMAN AVPR1A Vasopressin V1a receptor 9.313e-27 0.43
NRP1_RAT Nrp1 Neuropilin-1 6.621e-25 0.32
O07911_STAAU agrC AgrC 1.862e-24 0.32
ACKR3_HUMAN ACKR3 Atypical chemokine receptor 3 7.861e-24 0.40
ITAV_HUMAN ITGAV Integrin alpha-V 2.307e-23 0.39
V1AR_RAT Avpr1a Vasopressin V1a receptor 7.501e-23 0.42
ITA5_HUMAN ITGA5 Integrin alpha-5 8.542e-23 0.39
UR2R_RAT Uts2r Urotensin-2 receptor 1.823e-22 0.40
C5AR1_HUMAN C5AR1 C5a anaphylatoxin chemotactic receptor 1 4.905e-22 0.33
OXYR_MOUSE Oxtr Oxytocin receptor 7.268e-22 0.35
V2R_RAT Avpr2 Vasopressin V2 receptor 8.575e-20 0.40
LCAP_HUMAN LNPEP Leucyl-cystinyl aminopeptidase 1.939e-19 0.45
BIRC3_HUMAN BIRC3 Baculoviral IAP repeat-containing protein 3 1.955e-19 0.30
ITB5_HUMAN ITGB5 Integrin beta-5 2.884e-19 0.33
CBPN_HUMAN CPN1 Carboxypeptidase N catalytic chain 4.322e-19 0.29
SPSB2_HUMAN SPSB2 SPRY domain-containing SOCS box protein 2 1.173e-18 0.30
HDAC6_MOUSE Hdac6 Histone deacetylase 6 1.179e-17 0.33
EDNRB_PIG EDNRB Endothelin receptor type B 1.11e-16 0.35
SSR2_MOUSE Sstr2 Somatostatin receptor type 2 1.443e-15 0.30
HDAC1_MOUSE Hdac1 Histone deacetylase 1 2.887e-15 0.33
AGRA_STAAU agrA Accessory gene regulator protein A 8.75e-12 0.29
V1BR_RAT Avpr1b Vasopressin V1b receptor 1.034e-11 0.40
HDA11_HUMAN HDAC11 Histone deacetylase 11 1.461e-11 0.35
UR2R_HUMAN UTS2R Urotensin-2 receptor 4.641e-11 0.40
NTR1_RAT Ntsr1 Neurotensin receptor type 1 6.267e-11 0.30
SSR2_HUMAN SSTR2 Somatostatin receptor type 2 1.239e-10 0.39
SSR4_HUMAN SSTR4 Somatostatin receptor type 4 1.489e-10 0.38
PRTN3_HUMAN PRTN3 Myeloblastin 3.199e-10 0.31
MSHR_MOUSE Mc1r Melanocyte-stimulating hormone receptor 7.491e-10 0.42
HDA10_HUMAN HDAC10 Polyamine deacetylase HDAC10 1.795e-09 0.35
NTR1_MOUSE Ntsr1 Neurotensin receptor type 1 3.379e-09 0.28
MSHR_HUMAN MC1R Melanocyte-stimulating hormone receptor 4.986e-09 0.34
OPRK_CAVPO OPRK1 Kappa-type opioid receptor 1.59e-08 0.38
AMPN_HUMAN ANPEP Aminopeptidase N 1.73e-08 0.38
XIAP_HUMAN XIAP E3 ubiquitin-protein ligase XIAP 2.162e-08 0.30
NCOR1_HUMAN NCOR1 Nuclear receptor corepressor 1 2.734e-08 0.32
SSR1_HUMAN SSTR1 Somatostatin receptor type 1 3.006e-08 0.35
ITB1_HUMAN ITGB1 Integrin beta-1 5.785e-08 0.39
PIN1_HUMAN PIN1 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 8.38e-08 0.39
HDAC4_HUMAN HDAC4 Histone deacetylase 4 1.687e-07 0.33
CBPA1_HUMAN CPA1 Carboxypeptidase A1 3.365e-07 0.29
OPRX_CAVPO OPRL1 Nociceptin receptor 6.092e-07 0.32
HDAC1_RAT Hdac1 Histone deacetylase 1 1.054e-06 0.32
NTR1_HUMAN NTSR1 Neurotensin receptor type 1 1.313e-06 0.35
OPRD_HUMAN OPRD1 Delta-type opioid receptor 1.351e-06 0.38
NK3R_RAT Tacr3 Neuromedin-K receptor 1.43e-06 0.34
Q9S446_STAAU srtA Class A sortase SrtA 1.732e-06 0.33
OPRK_RAT Oprk1 Kappa-type opioid receptor 2.73e-06 0.36
MC3R_HUMAN MC3R Melanocortin receptor 3 4.312e-06 0.33
OPRM_MOUSE Oprm1 Mu-type opioid receptor 5.108e-06 0.45
TRY1_BOVIN Cationic trypsin 5.627e-06 0.31

Indenolol

B0FL73_CAVPO ADRB1 Beta-1 adrenergic receptor 1.252e-103 0.57
ADRB2_CAVPO Adrb2 Beta-2 adrenergic receptor 4.931e-93 0.62
ADRB1_RAT Adrb1 Beta-1 adrenergic receptor 2.559e-92 0.57
ADRB2_BOVIN ADRB2 Beta-2 adrenergic receptor 3.327e-81 0.57
CASR_BOVIN CASR Extracellular calcium-sensing receptor 1.381e-38 0.31
NAT_MYCSM nat Arylamine N-acetyltransferase 1.023e-37 0.30
DNMT1_MOUSE Dnmt1 DNA (cytosine-5)-methyltransferase 1 1.436e-37 0.37
Q5YLN7_CANLF SCN5A Voltage-gated sodium channel Nav1.5 cardiac isoform 1.195e-36 0.29
ADRB2_CANLF ADRB2 Beta-2 adrenergic receptor 6.71e-35 0.57
NTCP_HUMAN SLC10A1 Sodium/bile acid cotransporter 5.164e-26 0.57
ADRB1_HUMAN ADRB1 Beta-1 adrenergic receptor 2.903e-21 0.57
ANM5_HUMAN PRMT5 Protein arginine N-methyltransferase 5 3.842e-20 0.33
MEP50_HUMAN WDR77 Methylosome protein 50 9.887e-20 0.33
MDR1_HUMAN ABCB1 ATP-dependent translocase ABCB1 2.597e-18 0.37
ADRB2_HUMAN ADRB2 Beta-2 adrenergic receptor 1.617e-17 0.57
ADRB3_HUMAN ADRB3 Beta-3 adrenergic receptor 1.11e-16 0.57
CASR_HUMAN CASR Extracellular calcium-sensing receptor 3.886e-15 0.34
ADRB2_MOUSE Adrb2 Beta-2 adrenergic receptor 6.328e-14 0.34
ADRB2_MESAU ADRB2 Beta-2 adrenergic receptor 5.125e-13 0.28
GPR35_MOUSE Gpr35 G-protein coupled receptor 35 6.127e-12 0.32
CASR_RAT Casr Extracellular calcium-sensing receptor 1.327e-09 0.31
ADRB1_MOUSE Adrb1 Beta-1 adrenergic receptor 2.725e-07 0.28
5HT1B_RAT Htr1b 5-hydroxytryptamine receptor 1B 9.646e-07 0.57
S22A3_HUMAN SLC22A3 Solute carrier family 22 member 3 1.285e-06 0.30
NMT_CANAL NMT1 Glycylpeptide N-tetradecanoyltransferase 1.815e-06 0.47
FDFT_RAT Fdft1 Squalene synthase 3.231e-06 0.52

Triflusal

SCNAA_RAT Scn10a Sodium channel protein type 10 subunit alpha 1.273e-103 0.41
CFAD_RAT Cfd Complement factor D 4.616e-58 0.46
PPOM_TOBAC PPXII Protoporphyrinogen oxidase, mitochondrial 7.227e-49 0.39
HPPD_DAUCA 4-hydroxyphenylpyruvate dioxygenase 5.166e-42 0.33
PHHY_PSEFL pobA p-hydroxybenzoate hydroxylase 4.048e-41 0.33
PPARD_HUMAN PPARD Peroxisome proliferator-activated receptor delta 4.496e-41 0.35
AK1C2_HUMAN AKR1C2 Aldo-keto reductase family 1 member C2 6.667e-40 0.42
RXFP1_HUMAN RXFP1 Relaxin receptor 1 1.047e-39 0.33
H9BT73_9POAL ACCase 3.875e-36 0.29
SRPK1_MOUSE Srpk1 SRSF protein kinase 1 1.609e-35 0.28
PD2R2_RAT Ptgdr2 Prostaglandin D2 receptor 2 1.481e-26 0.33
PPARA_HUMAN PPARA Peroxisome proliferator-activated receptor alpha 3.048e-24 0.35
SORT_HUMAN SORT1 Sortilin 4.837e-23 0.42
AK1C3_HUMAN AKR1C3 Aldo-keto reductase family 1 member C3 4.086e-22 0.42
LIPL_HUMAN LPL Lipoprotein lipase 1.475e-20 0.33
PSBA_MARPO psbA Photosystem II protein D1 1.729e-19 0.32
CC14A_HUMAN CDC14A Dual specificity protein phosphatase CDC14A 4.879e-18 0.29
FFAR4_RAT Ffar4 Free fatty acid receptor 4 3.641e-17 0.33
Q38C41_TRYB2 Phosphotransferase 1.11e-16 0.32
TLR1_MOUSE Tlr1 Toll-like receptor 1 1.11e-16 0.31
TLR2_MOUSE Tlr2 Toll-like receptor 2 1.11e-16 0.31
AK1C1_HUMAN AKR1C1 Aldo-keto reductase family 1 member C1 4.441e-16 0.38
AK1C4_HUMAN AKR1C4 Aldo-keto reductase family 1 member C4 1.443e-15 0.37
PTP1_YEAST PTP1 Tyrosine-protein phosphatase 1 1.887e-15 0.29
CNR2_RAT Cnr2 Cannabinoid receptor 2 6.661e-15 0.32
HPPD_RAT Hpd 4-hydroxyphenylpyruvate dioxygenase 1.21e-14 0.32
PPARG_HUMAN PPARG Peroxisome proliferator-activated receptor gamma 2.143e-14 0.34
ACPS_BACSU acpS Holo-[acyl-carrier-protein] synthase 2.598e-14 0.32
FFAR1_MOUSE Ffar1 Free fatty acid receptor 1 9.814e-14 0.35
HAOX1_MOUSE Hao1 Hydroxyacid oxidase 1 3.959e-13 0.32
EST2_HUMAN CES2 Cocaine esterase 4.05e-13 0.45
PTN9_HUMAN PTPN9 Tyrosine-protein phosphatase non-receptor type 9 9.303e-13 0.29
GRIK1_HUMAN GRIK1 Glutamate receptor ionotropic, kainate 1 5.402e-12 0.38
LIPE_HUMAN LIPG Endothelial lipase 7.992e-12 0.43
Q9AQH7_STAAU dnaC Replicative DNA helicase 1.275e-11 0.28
Q76129_9HIV1 gag Structural capsid protein 1.594e-11 0.30
SC6A9_BOVIN SLC6A9 Sodium- and chloride-dependent glycine transporter 1 1.948e-11 0.29
PD2R2_HUMAN PTGDR2 Prostaglandin D2 receptor 2 6.292e-11 0.38
S12A5_RAT Slc12a5 Solute carrier family 12 member 5 1.374e-10 0.30
HAOX2_RAT Hao2 Hydroxyacid oxidase 2 1.957e-10 0.31
TRPV4_MOUSE Trpv4 Transient receptor potential cation channel subfamily V member 4 8.811e-10 0.28
AOX_TRYBB AOX Alternative oxidase, mitochondrial 9.06e-10 0.31
TRPV4_RAT Trpv4 Transient receptor potential cation channel subfamily V member 4 1.404e-09 0.32
PDS_SYNE7 pds 15-cis-phytoene desaturase 3.346e-09 0.28
PYRD_HUMAN DHODH Dihydroorotate dehydrogenase (quinone), mitochondrial 5.87e-09 0.33
PERM_HUMAN MPO Myeloperoxidase 6.818e-09 0.38
CCR2_MOUSE Ccr2 C-C chemokine receptor type 2 9.043e-09 0.38
HPPD_PIG HPD 4-hydroxyphenylpyruvate dioxygenase 9.919e-09 0.32
GSTP1_HUMAN GSTP1 Glutathione S-transferase P 1.119e-08 0.31
PTPA_MYCTU ptpA Probable low molecular weight protein-tyrosine-phosphatase 3.72e-08 0.29
UCHL1_HUMAN UCHL1 Ubiquitin carboxyl-terminal hydrolase isozyme L1 4.403e-08 0.33
FFAR4_MOUSE Ffar4 Free fatty acid receptor 4 5.051e-08 0.33
PGH1_BOVIN PTGS1 Prostaglandin G/H synthase 1 6.717e-08 0.53
RXRA_HUMAN RXRA Retinoic acid receptor RXR-alpha 7.097e-08 0.33
S5A2_HUMAN SRD5A2 3-oxo-5-alpha-steroid 4-dehydrogenase 2 7.716e-08 0.43
LIPS_HUMAN LIPE Hormone-sensitive lipase 7.774e-08 0.30
P2Y14_MOUSE P2ry14 P2Y purinoceptor 14 7.907e-08 0.30
IBP3_HUMAN IGFBP3 Insulin-like growth factor-binding protein 3 9.517e-08 0.32
Q56D28_CAVPO CRTH2 Chemoattractant receptor-homologous molecule expressed on Th2 cells 1.239e-07 0.33
PTN6_HUMAN PTPN6 Tyrosine-protein phosphatase non-receptor type 6 1.447e-07 0.29
PE2R1_HUMAN PTGER1 Prostaglandin E2 receptor EP1 subtype 1.727e-07 0.35
PD2R2_MOUSE Ptgdr2 Prostaglandin D2 receptor 2 2.413e-07 0.33
FABP4_HUMAN FABP4 Fatty acid-binding protein, adipocyte 3.759e-07 0.30
PSBA_SPIOL psbA Photosystem II protein D1 4.431e-07 0.32
IF4E_HUMAN EIF4E Eukaryotic translation initiation factor 4E 5.008e-07 0.32
CXCR5_HUMAN CXCR5 C-X-C chemokine receptor type 5 5.914e-07 0.30
KCMA1_HUMAN KCNMA1 Calcium-activated potassium channel subunit alpha-1 6.589e-07 0.30
SDF1_HUMAN CXCL12 Stromal cell-derived factor 1 7.608e-07 0.34
ACRO_HUMAN ACR Acrosin 8.355e-07 0.31
LTC4S_HUMAN LTC4S Leukotriene C4 synthase 1.151e-06 0.37
GPR52_HUMAN GPR52 G-protein coupled receptor 52 1.6e-06 0.29
PTN13_HUMAN PTPN13 Tyrosine-protein phosphatase non-receptor type 13 2.849e-06 0.29
PTPRG_HUMAN PTPRG Receptor-type tyrosine-protein phosphatase gamma 2.849e-06 0.29
CAC1B_HUMAN CACNA1B Voltage-dependent N-type calcium channel subunit alpha-1B 3.436e-06 0.33
DUS22_HUMAN DUSP22 Dual specificity protein phosphatase 22 4.596e-06 0.29
HNF4A_RAT Hnf4a Hepatocyte nuclear factor 4-alpha 5.201e-06 0.33
PPARA_CANLF PPARA Peroxisome proliferator-activated receptor alpha 7.612e-06 0.31
SC6A9_HUMAN SLC6A9 Sodium- and chloride-dependent glycine transporter 1 7.788e-06 0.38

Hexoprenaline

ADRB2_HUMAN ADRB2 Beta-2 adrenergic receptor 8.886e-103 0.72
ADRB3_HUMAN ADRB3 Beta-3 adrenergic receptor 2.406e-88 0.58
ADRB1_HUMAN ADRB1 Beta-1 adrenergic receptor 1.491e-83 0.58
ADRB1_MOUSE Adrb1 Beta-1 adrenergic receptor 1.118e-74 0.58
ADRB2_MESAU ADRB2 Beta-2 adrenergic receptor 4.807e-71 0.58
ADA2A_MOUSE Adra2a Alpha-2A adrenergic receptor 3.325e-66 0.53
ADA2C_MOUSE Adra2c Alpha-2C adrenergic receptor 3.325e-66 0.53
ADRB2_BOVIN ADRB2 Beta-2 adrenergic receptor 7.764e-61 0.58
ADRB2_CAVPO Adrb2 Beta-2 adrenergic receptor 9.88e-53 0.58
TYTR_CRIFA TPR Trypanothione reductase 1.75e-46 0.37
Q06347_9HIV2 reverse transcriptase Reverse transcriptase 6.694e-38 0.30
ADRB3_MOUSE Adrb3 Beta-3 adrenergic receptor 5.953e-37 0.29
SYFA_STAAU pheS Phenylalanine--tRNA ligase alpha subunit 2.072e-36 0.38
PA_I000X PA Polymerase acidic protein 2.178e-30 0.30
B0FL73_CAVPO ADRB1 Beta-1 adrenergic receptor 2.802e-26 0.58
ADRB2_RAT Adrb2 Beta-2 adrenergic receptor 1.532e-24 0.58
H9TVJ1_CHISP TyR1 1.444e-23 0.29
ARP19_RAT Arpp19 cAMP-regulated phosphoprotein 19 5.518e-23 0.28
ADRB2_CANLF ADRB2 Beta-2 adrenergic receptor 5.742e-23 0.62
ADRB1_RAT Adrb1 Beta-1 adrenergic receptor 1.488e-20 0.58
Q39829_SOYBN Lipoxygenase 2.322e-19 0.31
G3HDX1_CRIGR Alpha-1B adrenergic receptor 4.501e-19 0.37
ADRB3_RAT Adrb3 Beta-3 adrenergic receptor 7.354e-18 0.58
TYTR_TRYCR TPR Trypanothione reductase 9.384e-18 0.37
S6A13_MOUSE Slc6a13 Sodium- and chloride-dependent GABA transporter 2 1.332e-15 0.31
ADRB3_CANLF ADRB3 Beta-3 adrenergic receptor 1.399e-14 0.30
DYN1_HUMAN DNM1 Dynamin-1 7.996e-13 0.32
NMUR2_HUMAN NMUR2 Neuromedin-U receptor 2 1.346e-11 0.37
ACM3_HUMAN CHRM3 Muscarinic acetylcholine receptor M3 6.903e-11 0.39
COMT_PIG COMT Catechol O-methyltransferase 8.319e-11 0.34
RNH1_HUMAN RNASEH1 Ribonuclease H1 2.659e-10 0.30
S22A3_HUMAN SLC22A3 Solute carrier family 22 member 3 1.163e-08 0.41
LOX15_RABIT ALOX15 Arachidonate 15-lipoxygenase 6.238e-08 0.58
S6A11_MOUSE Slc6a11 Sodium- and chloride-dependent GABA transporter 3 1.746e-07 0.31
A0A0C7ACN7_PSEAI pqsD 3-oxoacyl-ACP synthase 1.092e-06 0.28

Sulfameter

S22AC_HUMAN SLC22A12 Solute carrier family 22 member 12 4.606e-91 0.37
BRD4_MOUSE Brd4 Bromodomain-containing protein 4 1.924e-47 0.30
BPTF_HUMAN BPTF Nucleosome-remodeling factor subunit BPTF 1.769e-45 0.30
Q81VW8_BACAN folP Dihydropteroate synthase 1.904e-43 0.33
Q56D22_MACMU HSD11B1 Hydroxysteroid 11-beta dehydrogenase 1 8.858e-37 0.29
LN28A_MOUSE Lin28a Protein lin-28 homolog A 3.875e-36 0.29
DAPAT_ARATH DAP LL-diaminopimelate aminotransferase, chloroplastic 8.333e-36 0.28
EDNRA_PIG EDNRA Endothelin-1 receptor 1.053e-35 0.38
CCR9_HUMAN CCR9 C-C chemokine receptor type 9 1.372e-33 0.37
LOX12_HUMAN ALOX12 Arachidonate 12-lipoxygenase, 12S-type 3.4e-31 0.35
QCR7_HUMAN UQCRB Cytochrome b-c1 complex subunit 7 1.28e-29 0.29
CYNT_HELPY cynT Carbonic anhydrase 3.327e-29 0.40
TIF1A_HUMAN TRIM24 Transcription intermediary factor 1-alpha 4.816e-28 0.37
Q5TU56_ANOGA 1272966 Carbonic anhydrase 1.005e-27 0.44
MGAT3_HUMAN MGAT3 Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase 2.021e-26 0.30
SMCA4_HUMAN SMARCA4 Transcription activator BRG1 7.777e-26 0.30
AKT1_MOUSE Akt1 RAC-alpha serine/threonine-protein kinase 8.109e-25 0.29
SMS1_HUMAN SGMS1 Phosphatidylcholine:ceramide cholinephosphotransferase 1 6.618e-24 0.31
SC5A7_RAT Slc5a7 High affinity choline transporter 1 1.114e-23 0.29
KEAP1_HUMAN KEAP1 Kelch-like ECH-associated protein 1 3.514e-23 0.43
MEP1B_HUMAN MEP1B Meprin A subunit beta 4.275e-23 0.38
5HT6R_MOUSE Htr6 5-hydroxytryptamine receptor 6 4.377e-23 0.28
FFAR4_RAT Ffar4 Free fatty acid receptor 4 2.315e-22 0.43
MMP13_HUMAN MMP13 Collagenase 3 2.069e-21 0.38
Q5U9J1_THAWE ca1 Delta carbonic anhydrase 2.833e-20 0.44
P3C2G_HUMAN PIK3C2G Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma 5.18e-20 0.42
C0IX24_STYPI CA2 Carbonic anhydrase 7.899e-20 0.40
CAH2_HUMAN CA2 Carbonic anhydrase 2 2.468e-19 0.44
MMP1_HUMAN MMP1 Interstitial collagenase 2.943e-19 0.38
PPBT_BOVIN ALPL Alkaline phosphatase, tissue-nonspecific isozyme 3.361e-19 0.38
B2V8E3_SULSY Carbonate dehydratase 4.444e-19 0.40
B5SU02_STYPI CA Alpha carbonic anhydrase 4.444e-19 0.40
Q31FD6_HYDCU Carbonic anhydrase, alpha family 4.444e-19 0.40
CAH9_HUMAN CA9 Carbonic anhydrase 9 6.177e-19 0.44
MMP9_HUMAN MMP9 Matrix metalloproteinase-9 1.065e-18 0.38
CAH1_HUMAN CA1 Carbonic anhydrase 1 1.069e-18 0.44
PPBI_BOVIN ALPI Intestinal-type alkaline phosphatase 1.188e-18 0.38
TOP2_PLAFK TOP2 DNA topoisomerase 2 1.523e-18 0.29
MMP12_MOUSE Mmp12 Macrophage metalloelastase 1.66e-18 0.30
FFAR4_HUMAN FFAR4 Free fatty acid receptor 4 1.952e-18 0.44
Q5XX84_CANLF HSD11B1 11-beta-hydroxysteroid dehydrogenase type 1 2.375e-18 0.29
BRD7_HUMAN BRD7 Bromodomain-containing protein 7 3.269e-18 0.30
A6YCJ1_9METZ Astrosclerin-3 4.429e-18 0.40
MTCA2_MYCTU mtcA2 Carbonic anhydrase 2 6.432e-18 0.40
SCN9A_HUMAN SCN9A Sodium channel protein type 9 subunit alpha 1.828e-17 0.36
Q388H8_TRYB2 Glycylpeptide N-tetradecanoyltransferase 2.819e-17 0.43
CAH2_BOVIN CA2 Carbonic anhydrase 2 4.563e-17 0.38
EDNRA_RAT Ednra Endothelin-1 receptor 4.441e-16 0.43
MMP8_HUMAN MMP8 Neutrophil collagenase 4.441e-16 0.38
CAN_YEAST NCE103 Carbonic anhydrase 5.551e-16 0.40
CAH12_HUMAN CA12 Carbonic anhydrase 12 1.665e-15 0.44
CAH13_MOUSE Ca13 Carbonic anhydrase 13 4.996e-15 0.44
MMP16_HUMAN MMP16 Matrix metalloproteinase-16 5.107e-15 0.32
MMP7_HUMAN MMP7 Matrilysin 5.884e-15 0.38
EDNRB_PIG EDNRB Endothelin receptor type B 1.332e-14 0.32
PRTN3_HUMAN PRTN3 Myeloblastin 2.287e-14 0.29
CAH_METTE Carbonic anhydrase 7.372e-14 0.38
KMO_RAT Kmo Kynurenine 3-monooxygenase 8.971e-14 0.38
MMP2_HUMAN MMP2 72 kDa type IV collagenase 1.655e-13 0.38
CP51_MYCTU cyp51 Lanosterol 14-alpha demethylase 2.311e-13 0.43
MMP3_HUMAN MMP3 Stromelysin-1 2.709e-13 0.38
PGES2_HUMAN PTGES2 Prostaglandin E synthase 2 4.224e-13 0.33
BMP1_HUMAN BMP1 Bone morphogenetic protein 1 8.223e-13 0.34
Q3I4V7_CRYNV CAN2 Carbonic anhydrase 1.198e-12 0.40
PPBT_HUMAN ALPL Alkaline phosphatase, tissue-nonspecific isozyme 1.211e-12 0.33
GHSR_HUMAN GHSR Growth hormone secretagogue receptor type 1 2.097e-12 0.33
MGAT1_HUMAN MGAT1 Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase 2.397e-12 0.30
S40A1_HUMAN SLC40A1 Solute carrier family 40 member 1 4.387e-12 0.38
CCR6_HUMAN CCR6 C-C chemokine receptor type 6 1.366e-11 0.30
MTCA1_MYCTU mtcA1 Beta-carbonic anhydrase 1 1.471e-11 0.40
CAH4_BOVIN CA4 Carbonic anhydrase 4 2.717e-11 0.44
BAZ2B_HUMAN BAZ2B Bromodomain adjacent to zinc finger domain protein 2B 2.748e-11 0.30
MGAT2_MOUSE Mgat2 Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase 3.122e-11 0.30
S22A8_HUMAN SLC22A8 Solute carrier family 22 member 8 4.581e-11 0.29
Q6FTL6_CANGA NCE103 Carbonic anhydrase 5.283e-11 0.40
CAH15_MOUSE Ca15 Carbonic anhydrase 15 7.631e-11 0.38
ADRB1_HUMAN ADRB1 Beta-1 adrenergic receptor 1.033e-10 0.44
ADRB3_HUMAN ADRB3 Beta-3 adrenergic receptor 1.046e-10 0.44
CCR4_HUMAN CCR4 C-C chemokine receptor type 4 1.504e-10 0.38
CAH14_HUMAN CA14 Carbonic anhydrase 14 3.136e-10 0.40
P96878_MYCTU Probable transmembrane carbonic anhydrase (Carbonate dehydratase) (Carbonic dehydratase) 3.848e-10 0.38
5HT6R_HUMAN HTR6 5-hydroxytryptamine receptor 6 4.119e-10 0.57
BRD1_HUMAN BRD1 Bromodomain-containing protein 1 5.809e-10 0.35
MMP14_HUMAN MMP14 Matrix metalloproteinase-14 7.587e-10 0.38
DYR_CANAX DFR1 Dihydrofolate reductase 7.945e-10 0.32
CAH6_HUMAN CA6 Carbonic anhydrase 6 1.411e-09 0.40
AOC1_HUMAN AOC1 Amiloride-sensitive amine oxidase [copper-containing] 2.401e-09 0.33
BRPF1_HUMAN BRPF1 Peregrin 2.852e-09 0.35
ADRB2_HUMAN ADRB2 Beta-2 adrenergic receptor 3.171e-09 0.44
LOX15_RABIT ALOX15 Arachidonate 15-lipoxygenase 4.174e-09 0.30
IKBA_HUMAN NFKBIA NF-kappa-B inhibitor alpha 7.419e-09 0.31
CAH5B_HUMAN CA5B Carbonic anhydrase 5B, mitochondrial 1.031e-08 0.40
ARY2_MOUSE Nat2 Arylamine N-acetyltransferase 2 2.181e-08 0.30
NLRP3_MOUSE Nlrp3 NACHT, LRR and PYD domains-containing protein 3 2.287e-08 0.30
CAH5A_HUMAN CA5A Carbonic anhydrase 5A, mitochondrial 3.031e-08 0.40
METC_ECOLI metC Cystathionine beta-lyase MetC 4.463e-08 0.32
CAN_CANAL NCE103 Carbonic anhydrase 5.811e-08 0.40
CAH7_HUMAN CA7 Carbonic anhydrase 7 5.973e-08 0.38
TBA1A_PIG TUBA1A Tubulin alpha-1A chain 7.133e-08 0.40
TNI3K_HUMAN TNNI3K Serine/threonine-protein kinase TNNI3K 7.486e-08 0.30
MMP12_HUMAN MMP12 Macrophage metalloelastase 8.528e-08 0.38
Q548M1_ECOLX groL 60 kDa chaperonin 8.956e-08 0.37
Q7BGE6_ECOLX groES 10 kDa chaperonin 8.956e-08 0.37
GSK3B_MOUSE Gsk3b Glycogen synthase kinase-3 beta 1.031e-07 0.29
PK3CG_HUMAN PIK3CG Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 1.511e-07 0.38
REV_HV1H2 rev Protein Rev 1.792e-07 0.29
PI4KA_HUMAN PI4KA Phosphatidylinositol 4-kinase alpha 2.847e-07 0.31
EDNRB_HUMAN EDNRB Endothelin receptor type B 3.153e-07 0.40
5NTD_HUMAN NT5E 5'-nucleotidase 4.078e-07 0.34
EDNRA_HUMAN EDNRA Endothelin-1 receptor 4.229e-07 0.31
AMYP_PIG AMY2 Pancreatic alpha-amylase 7.308e-07 0.29
KAT2B_HUMAN KAT2B Histone acetyltransferase KAT2B 1.148e-06 0.30
SCN8A_HUMAN SCN8A Sodium channel protein type 8 subunit alpha 1.841e-06 0.28
EAA1_HUMAN SLC1A3 Excitatory amino acid transporter 1 2.005e-06 0.37
ADA17_HUMAN ADAM17 Disintegrin and metalloproteinase domain-containing protein 17 2.371e-06 0.38
MP2K6_HUMAN MAP2K6 Dual specificity mitogen-activated protein kinase kinase 6 4.584e-06 0.31
ARAF_HUMAN ARAF Serine/threonine-protein kinase A-Raf 4.592e-06 0.29
LIMK2_HUMAN LIMK2 LIM domain kinase 2 5.43e-06 0.33
RPGF4_HUMAN RAPGEF4 Rap guanine nucleotide exchange factor 4 6.1e-06 0.30
SGK1_HUMAN SGK1 Serine/threonine-protein kinase Sgk1 9.924e-06 0.30

Parecoxib

GBRA5_HUMAN GABRA5 Gamma-aminobutyric acid receptor subunit alpha-5 2.54e-90 0.39
COX2_HUMAN MT-CO2 Cytochrome c oxidase subunit 2 8.65e-82 0.72
VE1_HPV11 E1 Replication protein E1 2.549e-72 0.33
PGH2_BOVIN PTGS2 Prostaglandin G/H synthase 2 2.148e-53 0.33
PFKA_TRYCC pfk ATP-dependent 6-phosphofructokinase 1.471e-44 0.33
PFKA_TRYBB pfk ATP-dependent 6-phosphofructokinase 1.331e-41 0.33
SYL_STAA8 leuS Leucine--tRNA ligase 2.644e-41 0.33
BRD2_HUMAN BRD2 Bromodomain-containing protein 2 8.855e-33 0.39
MEP1B_HUMAN MEP1B Meprin A subunit beta 7.155e-30 0.39
ATS4_HUMAN ADAMTS4 A disintegrin and metalloproteinase with thrombospondin motifs 4 1.46e-29 0.37
PGH2_SHEEP PTGS2 Prostaglandin G/H synthase 2 7.603e-29 0.36
RORG_MOUSE Rorc Nuclear receptor ROR-gamma 3.672e-28 0.35
BRD3_HUMAN BRD3 Bromodomain-containing protein 3 3.989e-28 0.39
SYL_ECOLI leuS Leucine--tRNA ligase 1.481e-26 0.33
MMP2_HUMAN MMP2 72 kDa type IV collagenase 1.779e-26 0.39
MMP12_HUMAN MMP12 Macrophage metalloelastase 5.288e-26 0.39
BRD4_HUMAN BRD4 Bromodomain-containing protein 4 7.454e-25 0.40
MMP13_BOVIN MMP13 Collagenase 3 2.372e-23 0.29
LIMK2_HUMAN LIMK2 LIM domain kinase 2 3.489e-23 0.34
MMP14_HUMAN MMP14 Matrix metalloproteinase-14 1.054e-21 0.39
FPR1_HUMAN FPR1 fMet-Leu-Phe receptor 1.198e-21 0.33
MMP16_HUMAN MMP16 Matrix metalloproteinase-16 3.891e-21 0.32
LOX15_RABIT ALOX15 Arachidonate 15-lipoxygenase 6.899e-21 0.33
MMP8_HUMAN MMP8 Neutrophil collagenase 5.393e-20 0.39
MMP9_HUMAN MMP9 Matrix metalloproteinase-9 1.004e-19 0.39
PGH2_HUMAN PTGS2 Prostaglandin G/H synthase 2 8.333e-19 0.72
FA10_BOVIN F10 Coagulation factor X 6.212e-18 0.32
CNR1_MOUSE Cnr1 Cannabinoid receptor 1 9.696e-18 0.32
ACK1_MOUSE Tnk2 Activated CDC42 kinase 1 2.181e-17 0.32
QCR7_HUMAN UQCRB Cytochrome b-c1 complex subunit 7 3.774e-17 0.33
DCMC_HUMAN MLYCD Malonyl-CoA decarboxylase, mitochondrial 1.11e-16 0.38
MMP13_HUMAN MMP13 Collagenase 3 1.11e-16 0.39
CAC1C_HUMAN CACNA1C Voltage-dependent L-type calcium channel subunit alpha-1C 3.331e-16 0.39
CAH4_BOVIN CA4 Carbonic anhydrase 4 1.443e-15 0.61
MCL1_HUMAN MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 5.44e-15 0.39
FFAR4_RAT Ffar4 Free fatty acid receptor 4 5.884e-15 0.28
GSP_CRIFA GSP Glutathionylspermidine synthase 6.328e-14 0.34
MCLN3_HUMAN MCOLN3 Mucolipin-3 1.769e-13 0.47
CAH2_HUMAN CA2 Carbonic anhydrase 2 2.214e-13 0.61
EDNRA_RAT Ednra Endothelin-1 receptor 3.786e-13 0.35
COLA_CLOPE colA Collagenase ColA 3.919e-13 0.33
TAF1L_HUMAN TAF1L Transcription initiation factor TFIID subunit 1-like 3.922e-13 0.29
CAH1_HUMAN CA1 Carbonic anhydrase 1 5.429e-13 0.38
PGH1_HUMAN PTGS1 Prostaglandin G/H synthase 1 1.322e-12 0.55
RORG_HUMAN RORC Nuclear receptor ROR-gamma 2.36e-12 0.37
GRM7_RAT Grm7 Metabotropic glutamate receptor 7 2.493e-12 0.32
PE2R4_HUMAN PTGER4 Prostaglandin E2 receptor EP4 subtype 3.101e-12 0.38
B2CL1_HUMAN BCL2L1 Bcl-2-like protein 1 5.934e-12 0.35
PA2GD_MOUSE Pla2g2d Group IID secretory phospholipase A2 6.016e-12 0.29
MMP3_HUMAN MMP3 Stromelysin-1 8.192e-12 0.39
CAH_METTE Carbonic anhydrase 9.381e-12 0.61
LX15B_HUMAN ALOX15B Arachidonate 15-lipoxygenase B 1.339e-11 0.28
SMS1_HUMAN SGMS1 Phosphatidylcholine:ceramide cholinephosphotransferase 1 1.383e-11 0.28
CAC1C_RAT Cacna1c Voltage-dependent L-type calcium channel subunit alpha-1C 2.218e-11 0.35
TASP1_HUMAN TASP1 Threonine aspartase 1 4.959e-11 0.30
RIR1_HUMAN RRM1 Ribonucleoside-diphosphate reductase large subunit 6.536e-11 0.29
HDAC4_HUMAN HDAC4 Histone deacetylase 4 6.988e-11 0.40
Q7T1G6_DANRE trpn1 Ion channel NompC 7.97e-11 0.35
EDNRA_HUMAN EDNRA Endothelin-1 receptor 8.587e-11 0.41
KC1D_RAT Csnk1d Casein kinase I isoform delta 9.037e-11 0.43
P4HTM_HUMAN P4HTM Transmembrane prolyl 4-hydroxylase 1.656e-10 0.34
MMP7_HUMAN MMP7 Matrilysin 3.79e-10 0.39
PD2R2_HUMAN PTGDR2 Prostaglandin D2 receptor 2 4.49e-10 0.35
KCNA5_HUMAN KCNA5 Potassium voltage-gated channel subfamily A member 5 4.978e-10 0.33
B5ATN6_PSEAI lpxC UDP-3-O-acyl-N-acetylglucosamine deacetylase 5.404e-10 0.29
MTCA2_MYCTU mtcA2 Carbonic anhydrase 2 6.415e-10 0.61
SYLC_HUMAN LARS1 Leucine--tRNA ligase, cytoplasmic 9.421e-10 0.33
GATA4_MOUSE Gata4 Transcription factor GATA-4 1.28e-09 0.40
NKX25_MOUSE Nkx2-5 Homeobox protein Nkx-2.5 1.28e-09 0.40
GPR55_HUMAN GPR55 G-protein coupled receptor 55 1.32e-09 0.36
PA2GF_HUMAN PLA2G2F Group IIF secretory phospholipase A2 2.494e-09 0.29
Q5TU56_ANOGA 1272966 Carbonic anhydrase 2.992e-09 0.61
CBP_HUMAN CREBBP CREB-binding protein 3.492e-09 0.31
CAH4_HUMAN CA4 Carbonic anhydrase 4 5.055e-09 0.61
CAN_YEAST NCE103 Carbonic anhydrase 7.246e-09 0.61
CAH9_HUMAN CA9 Carbonic anhydrase 9 8.201e-09 0.61
SCN3A_HUMAN SCN3A Sodium channel protein type 3 subunit alpha 8.738e-09 0.30
PA2GX_MOUSE Pla2g10 Group 10 secretory phospholipase A2 9.386e-09 0.29
TSPO_RAT Tspo Translocator protein 1.007e-08 0.31
PGH1_BOVIN PTGS1 Prostaglandin G/H synthase 1 1.461e-08 0.29
C0IX24_STYPI CA2 Carbonic anhydrase 1.601e-08 0.61
Q5U9J1_THAWE ca1 Delta carbonic anhydrase 1.601e-08 0.61
Q388H8_TRYB2 Glycylpeptide N-tetradecanoyltransferase 2.301e-08 0.32
HEPS_HUMAN HPN Serine protease hepsin 2.896e-08 0.33
Q962Y6_SCHMA TGR Thioredoxin glutathione reductase 3.105e-08 0.31
FFAR2_MOUSE Ffar2 Free fatty acid receptor 2 3.19e-08 0.31
CAH12_HUMAN CA12 Carbonic anhydrase 12 3.259e-08 0.61
B2V8E3_SULSY Carbonate dehydratase 3.276e-08 0.61
B5SU02_STYPI CA Alpha carbonic anhydrase 3.276e-08 0.61
Q31FD6_HYDCU Carbonic anhydrase, alpha family 3.276e-08 0.61
HAOX1_HUMAN HAO1 Hydroxyacid oxidase 1 4.168e-08 0.30
GPBAR_HUMAN GPBAR1 G-protein coupled bile acid receptor 1 5.189e-08 0.35
PGH2_MOUSE Ptgs2 Prostaglandin G/H synthase 2 5.789e-08 0.48
PA2GE_MOUSE Pla2g2e Group IIE secretory phospholipase A2 7.608e-08 0.29
A6YCJ1_9METZ Astrosclerin-3 8.504e-08 0.61
LIPL_RAT Lpl Lipoprotein lipase 1.031e-07 0.29
MMP1_HUMAN MMP1 Interstitial collagenase 1.214e-07 0.39
Q9BRH5_HUMAN DGAT1 DGAT1 protein 1.451e-07 0.32
PA2G5_MOUSE Pla2g5 Calcium-dependent phospholipase A2 1.77e-07 0.29
CAH5A_HUMAN CA5A Carbonic anhydrase 5A, mitochondrial 2.003e-07 0.61
CAH13_MOUSE Ca13 Carbonic anhydrase 13 2.626e-07 0.61
CAH7_HUMAN CA7 Carbonic anhydrase 7 3.113e-07 0.61
S12A2_HUMAN SLC12A2 Solute carrier family 12 member 2 3.445e-07 0.31
PA21B_MOUSE Pla2g1b Phospholipase A2 3.727e-07 0.29
PA2GE_HUMAN PLA2G2E Group IIE secretory phospholipase A2 3.727e-07 0.29
O39930_9HEPC NS5b RNA-directed RNA polymerase 3.865e-07 0.29
NR4A2_HUMAN NR4A2 Nuclear receptor subfamily 4 group A member 2 4.905e-07 0.29
PA2GA_MOUSE Pla2g2a Phospholipase A2, membrane associated 7.227e-07 0.29
PA2GD_HUMAN PLA2G2D Group IID secretory phospholipase A2 7.227e-07 0.29
HKDC1_HUMAN HKDC1 Hexokinase HKDC1 8.329e-07 0.35
P96878_MYCTU Probable transmembrane carbonic anhydrase (Carbonate dehydratase) (Carbonic dehydratase) 8.354e-07 0.61
PGH1_SHEEP PTGS1 Prostaglandin G/H synthase 1 1.273e-06 0.36
EAA2_HUMAN SLC1A2 Excitatory amino acid transporter 2 1.814e-06 0.33
CAH5B_HUMAN CA5B Carbonic anhydrase 5B, mitochondrial 2.291e-06 0.61
CAN1_RAT Capn1 Calpain-1 catalytic subunit 2.728e-06 0.31
SO1B1_HUMAN SLCO1B1 Solute carrier organic anion transporter family member 1B1 3.105e-06 0.28
PA2GX_HUMAN PLA2G10 Group 10 secretory phospholipase A2 3.447e-06 0.30
CAH6_HUMAN CA6 Carbonic anhydrase 6 3.785e-06 0.61
CPNS1_PIG CAPNS1 Calpain small subunit 1 5.065e-06 0.31
PTGES_HUMAN PTGES Prostaglandin E synthase 5.25e-06 0.47
PSB5_HUMAN PSMB5 Proteasome subunit beta type-5 5.895e-06 0.32
Q4Q5S8_LEIMA NMT Glycylpeptide N-tetradecanoyltransferase 7.842e-06 0.31
TRY2_BOVIN Anionic trypsin 8.524e-06 0.31
PCNA_HUMAN PCNA Proliferating cell nuclear antigen 8.994e-06 0.29
EAA1_HUMAN SLC1A3 Excitatory amino acid transporter 1 9.359e-06 0.33

Ulipristal

F1Q298_CANLF NR3C1 Glucocorticoid receptor 4.451e-84 0.73
GCR_PIG NR3C1 Glucocorticoid receptor 4.451e-84 0.73
PRGR_RAT Pgr Progesterone receptor 4.456e-82 0.73
PRGR_HUMAN PGR Progesterone receptor 4.382e-74 0.76
GCR_HUMAN NR3C1 Glucocorticoid receptor 4.096e-58 0.73
GCR_MOUSE Nr3c1 Glucocorticoid receptor 8.842e-43 0.73
CBG_HUMAN SERPINA6 Corticosteroid-binding globulin 5.411e-34 0.38
SHBG_RAT Shbg Sex hormone-binding globulin 8.57e-32 0.39
GCR_RAT Nr3c1 Glucocorticoid receptor 4.634e-28 0.73
Q690N0_BOVIN PGR Progesterone receptor 4.588e-24 0.73
SHBG_HUMAN SHBG Sex hormone-binding globulin 8.882e-16 0.38
MCR_HUMAN NR3C2 Mineralocorticoid receptor 1.214e-12 0.73
ANDR_HUMAN AR Androgen receptor 2.14e-11 0.73
PRGR_RABIT PGR Progesterone receptor 7.753e-10 0.35
FABPL_RAT Fabp1 Fatty acid-binding protein, liver 2.247e-09 0.29
GLNA_HUMAN GLUL Glutamine synthetase 2.247e-09 0.29
ANDR_RAT Ar Androgen receptor 7.268e-09 0.73
IL6_HUMAN IL6 Interleukin-6 1.631e-07 0.29
VP16_HHV11 Tegument protein VP16 9.461e-07 0.73

Hyaluronic_acid

MAG_HUMAN MAG Myelin-associated glycoprotein 2.497e-77 0.41
KLRBA_RAT Klrb1a Killer cell lectin-like receptor subfamily B member 1A 7.644e-75 0.50
LEG4_HUMAN LGALS4 Galectin-4 3.346e-70 0.48
LEG8_HUMAN LGALS8 Galectin-8 3.346e-70 0.48
AMYP_HUMAN AMY2A Pancreatic alpha-amylase 7.748e-61 0.36
FIMH_ECOLI fimH Type 1 fimbrin D-mannose specific adhesin 1.216e-58 0.35
FGF2_HUMAN FGF2 Fibroblast growth factor 2 2.884e-57 0.41
B4GT1_BOVIN B4GALT1 Beta-1,4-galactosyltransferase 1 4.198e-56 0.37
P79074_9AGAR cppg1 Endopolygalacturonase 1.696e-55 0.44
GGTA1_PIG GGTA1 N-acetyllactosaminide alpha-1,3-galactosyltransferase 9.335e-55 0.44
LEG3_HUMAN LGALS3 Galectin-3 6.739e-45 0.48
FGF1_HUMAN FGF1 Fibroblast growth factor 1 2.108e-44 0.42
CXB2_HUMAN GJB2 Gap junction beta-2 protein 2.269e-41 0.33
CHIT_YEAST CTS1 Endochitinase 1.527e-33 0.42
B4EH87_BURCJ Lectin 2.362e-33 0.35
CD69_HUMAN CD69 Early activation antigen CD69 1.421e-22 0.57
TYRO_HUMAN TYR Tyrosinase 1.721e-19 0.32
VEGFA_HUMAN VEGFA Vascular endothelial growth factor A 2.835e-19 0.41
AMY1A_HUMAN AMY1A Alpha-amylase 1 1.882e-17 0.33
HXK2_HUMAN HK2 Hexokinase-2 8.882e-16 0.31
P94451_GEOSE Alpha-amylase 3.442e-15 0.33
HXK1_HUMAN HK1 Hexokinase-1 3.209e-14 0.31
BGAL_HUMAN GLB1 Beta-galactosidase 1.66e-10 0.46
LEG7_HUMAN LGALS7; LGALS7B Galectin-7 2.701e-10 0.39
SC5A1_RAT Slc5a1 Sodium/glucose cotransporter 1 8.682e-10 0.28
FABH_ECOLI fabH 3-oxoacyl-[acyl-carrier-protein] synthase 3 7.367e-09 0.33
RASH_HUMAN HRAS GTPase HRas 1.006e-08 0.32
CHIA_HUMAN CHIA Acidic mammalian chitinase 9.502e-08 0.42
SC5A2_RAT Slc5a2 Sodium/glucose cotransporter 2 1.149e-07 0.28
PARG_RAT Parg Poly(ADP-ribose) glycohydrolase 1.305e-07 0.30
LEG9_HUMAN LGALS9 Galectin-9 2.807e-07 0.32
CHIB_SERMA chiB Chitinase B 3.778e-07 0.42
PDIA1_HUMAN P4HB Protein disulfide-isomerase 4.58e-07 0.32
SO1A1_RAT Slco1a1 Solute carrier organic anion transporter family member 1A1 5.363e-07 0.28
SUIS_HUMAN SI Sucrase-isomaltase, intestinal 2.02e-06 0.30
CAH14_HUMAN CA14 Carbonic anhydrase 14 3.324e-06 0.33
SO1B1_HUMAN SLCO1B1 Solute carrier organic anion transporter family member 1B1 3.597e-06 0.28
HDAH_ALCSD hdaH Histone deacetylase-like amidohydrolase 3.736e-06 0.40
HPSE_HUMAN HPSE Heparanase 6.778e-06 0.41

Icosapent_ethyl

TRPV2_RAT Trpv2 Transient receptor potential cation channel subfamily V member 2 8.25e-75 0.53
A3QR02_CHISP est1 Carboxylic ester hydrolase 3.241e-65 0.41
LOXX_SOYBN LOX1.4 Seed linoleate 9S-lipoxygenase 2.558e-55 0.44
CNR1_RAT Cnr1 Cannabinoid receptor 1 2.146e-50 0.58
LPAR4_HUMAN LPAR4 Lysophosphatidic acid receptor 4 1.754e-46 0.37
LPAR4_MOUSE Lpar4 Lysophosphatidic acid receptor 4 3.286e-46 0.37
P2Y10_HUMAN P2RY10 Putative P2Y purinoceptor 10 7.484e-44 0.32
PIN4_HUMAN PIN4 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 2.435e-37 0.30
CNR2_MOUSE Cnr2 Cannabinoid receptor 2 5.271e-33 0.45
OXER1_HUMAN OXER1 Oxoeicosanoid receptor 1 1.112e-32 0.62
GP174_HUMAN GPR174 Probable G-protein coupled receptor 174 4.004e-32 0.32
LPAR6_HUMAN LPAR6 Lysophosphatidic acid receptor 6 1.127e-29 0.37
GPR34_HUMAN GPR34 Probable G-protein coupled receptor 34 4.444e-26 0.32
PA1B2_HUMAN PAFAH1B2 Platelet-activating factor acetylhydrolase IB subunit beta 8.092e-26 0.32
POLI_MOUSE Poli DNA polymerase iota 4.179e-25 0.31
CNR1_MOUSE Cnr1 Cannabinoid receptor 1 1.098e-21 0.40
MGLL_RAT Mgll Monoglyceride lipase 1.476e-20 0.51
AMD_HUMAN PAM Peptidyl-glycine alpha-amidating monooxygenase 2.382e-20 0.33
MPIP2_MOUSE Cdc25b M-phase inducer phosphatase 2 1.858e-18 0.38
FAAH1_HUMAN FAAH Fatty-acid amide hydrolase 1 1.11e-16 0.52
Q8HY88_BOVIN KCNK2 Potassium channel subfamily K member 2 2.22e-16 0.40
POLH_HUMAN POLH DNA polymerase eta 3.331e-16 0.31
LPAR2_HUMAN LPAR2 Lysophosphatidic acid receptor 2 5.551e-16 0.38
KPCL_MOUSE Prkch Protein kinase C eta type 3.109e-15 0.29
LPAR3_HUMAN LPAR3 Lysophosphatidic acid receptor 3 4.13e-14 0.38
FABPH_HUMAN FABP3 Fatty acid-binding protein, heart 7.783e-14 0.54
PRP19_YEAST PRP19 Pre-mRNA-processing factor 19 2.862e-13 0.29
LOX15_PIG ALOX15 Arachidonate 15-lipoxygenase 7.131e-13 0.29
HYES_MOUSE Ephx2 Bifunctional epoxide hydrolase 2 1.128e-12 0.32
POLK_HUMAN POLK DNA polymerase kappa 1.238e-12 0.31
KPCA_BOVIN PRKCA Protein kinase C alpha type 1.854e-11 0.39
CNR1_HUMAN CNR1 Cannabinoid receptor 1 5.619e-11 0.58
TLR2_HUMAN TLR2 Toll-like receptor 2 8.169e-11 0.41
FAAH1_RAT Faah Fatty-acid amide hydrolase 1 1.233e-10 0.57
HIS7_ECOLI hisB Histidine biosynthesis bifunctional protein HisB 1.415e-10 0.28
LPXC_AQUAE lpxC UDP-3-O-acyl-N-acetylglucosamine deacetylase 1.415e-10 0.28
TNFA_HUMAN TNF Tumor necrosis factor 2.873e-10 0.35
GPR18_HUMAN GPR18 N-arachidonyl glycine receptor 9.083e-09 0.41
Q95214_RABIT ACAT Acyl-CoA:cholesterol acyltransferase 1.228e-07 0.38
PPO2_AGABI PPO2 Polyphenol oxidase 2 2.344e-07 0.49
FAAH1_MOUSE Faah Fatty-acid amide hydrolase 1 4.847e-07 0.32
HYES_HUMAN EPHX2 Bifunctional epoxide hydrolase 2 5.827e-07 0.36
LPAR1_HUMAN LPAR1 Lysophosphatidic acid receptor 1 6.472e-07 0.38
DPOL_VACCW POL DNA polymerase 1.716e-06 0.32
GPR34_MOUSE Gpr34 Probable G-protein coupled receptor 34 1.803e-06 0.32
PAPA1_CARPA Papain 2.394e-06 0.31
LOX5_RAT Alox5 Arachidonate 5-lipoxygenase 2.641e-06 0.45
CNR2_RAT Cnr2 Cannabinoid receptor 2 2.927e-06 0.49
CAC1C_RAT Cacna1c Voltage-dependent L-type calcium channel subunit alpha-1C 9.923e-06 0.47

Glycerol_phenylbutyrate

LOX15_RAT Alox15 Arachidonate 15-lipoxygenase 3.278e-68 0.44
EST1_HUMAN CES1 Liver carboxylesterase 1 4.316e-66 0.40
GPR34_MOUSE Gpr34 Probable G-protein coupled receptor 34 3.557e-65 0.32
MGLL_RAT Mgll Monoglyceride lipase 9.987e-63 0.55
FAAH1_RAT Faah Fatty-acid amide hydrolase 1 2.308e-62 0.55
Q9K2N0_PSEAI blaVIM-2 Beta-lactamase class B VIM-2 1.772e-59 0.39
CBPA3_HUMAN CPA3 Mast cell carboxypeptidase A 3.068e-58 0.33
DGLA_HUMAN DAGLA Sn1-specific diacylglycerol lipase alpha 9.67e-58 0.35
GP174_HUMAN GPR174 Probable G-protein coupled receptor 174 2.626e-56 0.30
PDS_SYNE7 pds 15-cis-phytoene desaturase 2.271e-55 0.33
P2Y10_HUMAN P2RY10 Putative P2Y purinoceptor 10 7.628e-55 0.31
FAAH1_HUMAN FAAH Fatty-acid amide hydrolase 1 1.176e-53 0.50
GPR34_HUMAN GPR34 Probable G-protein coupled receptor 34 1.01e-52 0.31
Q8QGU2_CHICK FKBP12.6 Peptidylprolyl isomerase 2.165e-50 0.34
FAAH1_MOUSE Faah Fatty-acid amide hydrolase 1 4.481e-47 0.40
S15A1_HUMAN SLC15A1 Solute carrier family 15 member 1 6.328e-47 0.34
EST1D_MOUSE Ces1d Carboxylesterase 1D 5.947e-46 0.31
PPCE_PIG PREP Prolyl endopeptidase 4.682e-42 0.36
GLT_PYRHO Glutamate transporter homolog 5.166e-42 0.33
NAAA_RAT Naaa N-acylethanolamine-hydrolyzing acid amidase 1.278e-41 0.34
Q99P97_RAT Histone deacetylase 6 1.841e-40 0.32
MCAT_HUMAN SLC25A20 Mitochondrial carnitine/acylcarnitine carrier protein 6.694e-38 0.30
LAT1_HUMAN SLC7A5 Large neutral amino acids transporter small subunit 1 1.081e-36 0.30
AMPL_PIG LAP3 Cytosol aminopeptidase 1.548e-35 0.35
Q8ILP4_PLAF7 Pantothenate kinase, putative 1.609e-35 0.28
FKB1A_RAT Fkbp1a Peptidyl-prolyl cis-trans isomerase FKBP1A 2.682e-35 0.32
SCN2A_HUMAN SCN2A Sodium channel protein type 2 subunit alpha 2.967e-35 0.35
CRTM_STAAU crtM 4,4'-diapophytoene synthase 3.854e-34 0.33
TLR2_HUMAN TLR2 Toll-like receptor 2 3.998e-31 0.34
AMD_RAT Pam Peptidylglycine alpha-amidating monooxygenase 6.158e-31 0.33
PPCE_BOVIN PREP Prolyl endopeptidase 1.389e-30 0.36
CBPA1_BOVIN CPA1 Carboxypeptidase A1 6.096e-30 0.40
AMPN_PIG ANPEP Aminopeptidase N 7.823e-30 0.39
AMD_HUMAN PAM Peptidyl-glycine alpha-amidating monooxygenase 2.427e-29 0.37
AMPL_HUMAN LAP3 Cytosol aminopeptidase 4.373e-29 0.31
GSHR_PLAF7 GR3 Glutathione reductase 6.123e-27 0.31
HMOX1_HUMAN HMOX1 Heme oxygenase 1 1.792e-26 0.33
NAAA_HUMAN NAAA N-acylethanolamine-hydrolyzing acid amidase 9.587e-26 0.33
AMP1_PLAFQ M1 family aminopeptidase 1.738e-25 0.35
Q704V1_PSEAI blaGIM-1 GIM-1 protein 1.81e-25 0.31
KPCA_BOVIN PRKCA Protein kinase C alpha type 6.143e-25 0.44
FAAH2_HUMAN FAAH2 Fatty-acid amide hydrolase 2 1.132e-24 0.30
ASAH1_HUMAN ASAH1 Acid ceramidase 3.921e-24 0.32
Q6RY99_RAT Tetraspanin 4.054e-24 0.36
KPCL_MOUSE Prkch Protein kinase C eta type 7.309e-23 0.44
A0A0C7ACN7_PSEAI pqsD 3-oxoacyl-ACP synthase 1.127e-22 0.38
AMPN_HUMAN ANPEP Aminopeptidase N 1.274e-22 0.35
CBPA1_HUMAN CPA1 Carboxypeptidase A1 3.696e-22 0.40
HDAC1_RAT Hdac1 Histone deacetylase 1 1.114e-21 0.28
MDR1_HUMAN ABCB1 ATP-dependent translocase ABCB1 8.541e-21 0.33
CAN2_BOVIN CAPN2 Calpain-2 catalytic subunit 6.741e-19 0.30
LX15B_RAT Alox15b Arachidonate 15-lipoxygenase B 7.594e-19 0.31
LKHA4_HUMAN LTA4H Leukotriene A-4 hydrolase 1.641e-18 0.37
LIPL_HUMAN LPL Lipoprotein lipase 2.375e-18 0.29
GNPAT_HUMAN GNPAT Dihydroxyacetone phosphate acyltransferase 4.879e-18 0.29
5HT2C_RAT Htr2c 5-hydroxytryptamine receptor 2C 5.776e-18 0.37
Q94F81_MAIZE hda106 HD2 type histone deacetylase HDA106 1.271e-17 0.32
CTRB1_HUMAN CTRB1 Chymotrypsinogen B 1.85e-17 0.34
AOFA_BOVIN MAOA Amine oxidase [flavin-containing] A 1.879e-17 0.33
EAA4_RAT Slc1a6 Excitatory amino acid transporter 4 1.882e-17 0.33
S15A2_RAT Slc15a2 Solute carrier family 15 member 2 4.252e-17 0.30
SCNNA_HUMAN SCNN1A Amiloride-sensitive sodium channel subunit alpha 1.11e-16 0.31
FFAR1_HUMAN FFAR1 Free fatty acid receptor 1 3.331e-16 0.41
ADA_HUMAN ADA Adenosine deaminase 8.882e-16 0.31
SCN3A_RAT Scn3a Sodium channel protein type 3 subunit alpha 1.665e-15 0.29
LT4R1_HUMAN LTB4R Leukotriene B4 receptor 1 2.22e-15 0.34
FKB1A_HUMAN FKBP1A Peptidyl-prolyl cis-trans isomerase FKBP1A 4.552e-15 0.34
SGMR1_HUMAN SIGMAR1 Sigma non-opioid intracellular receptor 1 4.774e-15 0.37
CP2E1_HUMAN CYP2E1 Cytochrome P450 2E1 7.772e-15 0.28
LOX15_PIG ALOX15 Arachidonate 15-lipoxygenase 8.882e-15 0.35
ERAP2_HUMAN ERAP2 Endoplasmic reticulum aminopeptidase 2 1.099e-14 0.31
CA2D1_MOUSE Cacna2d1 Voltage-dependent calcium channel subunit alpha-2/delta-1 1.488e-14 0.40
Q53I59_TRYCR PDEC Phosphodiesterase 2.331e-14 0.40
ISPA_ECOLI ispA Farnesyl diphosphate synthase 4.43e-14 0.31
AK1C3_HUMAN AKR1C3 Aldo-keto reductase family 1 member C3 4.496e-14 0.33
PA24B_HUMAN PLA2G4B Cytosolic phospholipase A2 beta 4.974e-14 0.33
O93874_COCLU 17HSDcl 17beta-hydroxysteroid dehydrogenase 6.173e-14 0.30
LPAR1_HUMAN LPAR1 Lysophosphatidic acid receptor 1 8.848e-14 0.43
FDFT_HUMAN FDFT1 Squalene synthase 9.859e-14 0.33
B0FL73_CAVPO ADRB1 Beta-1 adrenergic receptor 1.412e-13 0.38
LOX5_RAT Alox5 Arachidonate 5-lipoxygenase 1.414e-13 0.51
AK1BA_HUMAN AKR1B10 Aldo-keto reductase family 1 member B10 2.247e-13 0.36
TRPA1_RAT Trpa1 Transient receptor potential cation channel subfamily A member 1 2.391e-13 0.39
CBS_HUMAN CBS Cystathionine beta-synthase 2.602e-13 0.36
PPCE_MOUSE Prep Prolyl endopeptidase 3.361e-13 0.36
AMPB_RAT Rnpep Aminopeptidase B 3.372e-13 0.28
NEP_MOUSE Mme Neprilysin 3.922e-13 0.29
NK1R_RAT Tacr1 Substance-P receptor 4.402e-13 0.34
FFAR4_HUMAN FFAR4 Free fatty acid receptor 4 5.662e-13 0.32
MMP3_HUMAN MMP3 Stromelysin-1 1.64e-12 0.32
POLG_CXB3N Genome polyprotein 1.643e-12 0.36
VMAT2_RAT Slc18a2 Synaptic vesicular amine transporter 3.675e-12 0.36
FDFT_RAT Fdft1 Squalene synthase 4.533e-12 0.33
OPRK_RAT Oprk1 Kappa-type opioid receptor 6.227e-12 0.33
SCN5A_HUMAN SCN5A Sodium channel protein type 5 subunit alpha 7.956e-12 0.35
MGLL_HUMAN MGLL Monoglyceride lipase 9.451e-12 0.55
SC6A3_RAT Slc6a3 Sodium-dependent dopamine transporter 1.529e-11 0.39
HYEP_MOUSE Ephx1 Epoxide hydrolase 1 2.223e-11 0.36
PPCE_HUMAN PREP Prolyl endopeptidase 3.018e-11 0.36
LPAR3_HUMAN LPAR3 Lysophosphatidic acid receptor 3 3.439e-11 0.43
KDM4D_HUMAN KDM4D Lysine-specific demethylase 4D 5.194e-11 0.35
LOX5_HUMAN ALOX5 Arachidonate 5-lipoxygenase 5.637e-11 0.51
VEGFA_HUMAN VEGFA Vascular endothelial growth factor A 5.758e-11 0.32
CATH_HUMAN CTSH Pro-cathepsin H 7.057e-11 0.31
SSPA_STAAU sspA Glutamyl endopeptidase 1.105e-10 0.29
Q98UH1_DANRE oprm1 Mu opioid receptor-like OR2 1.647e-10 0.28
HPPD_ARATH HPD 4-hydroxyphenylpyruvate dioxygenase 1.761e-10 0.33
AOFB_BOVIN MAOB Amine oxidase [flavin-containing] B 2.209e-10 0.31
KDM6B_HUMAN KDM6B Lysine-specific demethylase 6B 3.69e-10 0.35
PF2R_BOVIN PTGFR Prostaglandin F2-alpha receptor 4.202e-10 0.34
NANA_STREE nanA Sialidase A 4.884e-10 0.29
Q0GKD7_LEIDO Farnesyl pyrophosphate synthase 6.853e-10 0.31
FOLH1_RAT Folh1 Glutamate carboxypeptidase 2 7.923e-10 0.33
SCYD_MAGO7 SDH1 Scytalone dehydratase 1.629e-09 0.35
Q79MP6_PSEAI blaIMP-1 Beta-lactamase 1.836e-09 0.33
HCAR2_RAT Hcar2 Hydroxycarboxylic acid receptor 2 1.985e-09 0.33
Q6TUJ4_PSEAI blaIMP-1 Metallo beta-lactamase 2.232e-09 0.35
CEL2A_PIG CELA2A Chymotrypsin-like elastase family member 2A 2.318e-09 0.31
COMT_RAT Comt Catechol O-methyltransferase 2.562e-09 0.35
TRPM8_RAT Trpm8 Transient receptor potential cation channel subfamily M member 8 2.961e-09 0.38
IMPA1_BOVIN IMPA1 Inositol monophosphatase 1 3.025e-09 0.31
P2RX4_HUMAN P2RX4 P2X purinoceptor 4 3.692e-09 0.32
TAAR1_HUMAN TAAR1 Trace amine-associated receptor 1 3.879e-09 0.38
EST5_RAT Liver carboxylesterase B-1 4.08e-09 0.30
CMA1_HUMAN CMA1 Chymase 4.972e-09 0.39
LIPE_MOUSE Lipg Endothelial lipase 6.102e-09 0.33
CAN2_HUMAN CAPN2 Calpain-2 catalytic subunit 7.424e-09 0.36
PLCG2_HUMAN PLCG2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 9.732e-09 0.33
Q6FTL6_CANGA NCE103 Carbonic anhydrase 1.447e-08 0.29
MGLL_MOUSE Mgll Monoglyceride lipase 1.468e-08 0.31
ERAP1_HUMAN ERAP1 Endoplasmic reticulum aminopeptidase 1 1.57e-08 0.31
S22A6_RAT Slc22a6 Solute carrier family 22 member 6 2.148e-08 0.31
HYES_HUMAN EPHX2 Bifunctional epoxide hydrolase 2 2.687e-08 0.38
5HT2A_RAT Htr2a 5-hydroxytryptamine receptor 2A 3.131e-08 0.37
HYEP_HUMAN EPHX1 Epoxide hydrolase 1 3.744e-08 0.36
CASP1_HUMAN CASP1 Caspase-1 4.066e-08 0.38
GRIK3_RAT Grik3 Glutamate receptor ionotropic, kainate 3 4.266e-08 0.41
FPPS_HUMAN FDPS Farnesyl pyrophosphate synthase 5.854e-08 0.36
Q9BEG3_BOVIN 5-lipoxygenase 6.488e-08 0.36
PPARG_HUMAN PPARG Peroxisome proliferator-activated receptor gamma 7.186e-08 0.39
GSHR_HUMAN GSR Glutathione reductase, mitochondrial 7.42e-08 0.31
Q6UB75_PIG Group VII phospholipase A2 7.801e-08 0.32
MMP2_HUMAN MMP2 72 kDa type IV collagenase 1.254e-07 0.32
ACE_RABIT ACE Angiotensin-converting enzyme 1.27e-07 0.40
S1PR3_HUMAN S1PR3 Sphingosine 1-phosphate receptor 3 1.555e-07 0.36
BLA1_ECOLX bla Beta-lactamase SHV-1 1.696e-07 0.31
ENPP2_MOUSE Enpp2 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 1.848e-07 0.33
DCMC_HUMAN MLYCD Malonyl-CoA decarboxylase, mitochondrial 1.9e-07 0.34
AK1C4_HUMAN AKR1C4 Aldo-keto reductase family 1 member C4 2.163e-07 0.30
CAH5A_HUMAN CA5A Carbonic anhydrase 5A, mitochondrial 2.429e-07 0.32
CATG_HUMAN CTSG Cathepsin G 3.133e-07 0.31
CATK_HUMAN CTSK Cathepsin K 3.381e-07 0.36
DXR_MYCTU dxr 1-deoxy-D-xylulose 5-phosphate reductoisomerase 3.706e-07 0.32
LPAR1_RAT Lpar1 Lysophosphatidic acid receptor 1 3.814e-07 0.30
A5Z252_9INFA Neuraminidase 4.538e-07 0.29
CBPB1_PIG CPB1 Carboxypeptidase B 6.148e-07 0.28
ADRB2_CAVPO Adrb2 Beta-2 adrenergic receptor 6.169e-07 0.35
S1PR1_HUMAN S1PR1 Sphingosine 1-phosphate receptor 1 7.347e-07 0.36
MMP12_HUMAN MMP12 Macrophage metalloelastase 7.867e-07 0.33
CATB_BOVIN CTSB Cathepsin B 8.184e-07 0.33
GABR1_RAT Gabbr1 Gamma-aminobutyric acid type B receptor subunit 1 8.954e-07 0.33
SPHK1_HUMAN SPHK1 Sphingosine kinase 1 9.97e-07 0.33
NR1H4_MOUSE Nr1h4 Bile acid receptor 1.054e-06 0.32
CYSP_TRYCR Cruzipain 1.468e-06 0.32
EAA3_HUMAN SLC1A1 Excitatory amino acid transporter 3 1.892e-06 0.33
BLA2_BACCE blm Metallo-beta-lactamase type 2 1.938e-06 0.32
OXDA_MOUSE Dao D-amino-acid oxidase 2.064e-06 0.30
Q63380_RAT NET Transporter 2.443e-06 0.33
PIN1_HUMAN PIN1 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 2.617e-06 0.30
GRIA4_RAT Gria4 Glutamate receptor 4 2.798e-06 0.34
FOLH1_HUMAN FOLH1 Glutamate carboxypeptidase 2 2.816e-06 0.35
MMP8_HUMAN MMP8 Neutrophil collagenase 2.991e-06 0.36
PPCE_RAT Prep Prolyl endopeptidase 3.024e-06 0.36
NRAM_I77AB Neuraminidase 3.119e-06 0.29
CAN_CANAL NCE103 Carbonic anhydrase 3.236e-06 0.29
KPCA_HUMAN PRKCA Protein kinase C alpha type 3.405e-06 0.44
NMDE2_RAT Grin2b Glutamate receptor ionotropic, NMDA 2B 4.009e-06 0.33
H9B8T9_CAPHI CTSB Cathepsin B 4.158e-06 0.36
OXDA_PIG DAO D-amino-acid oxidase 4.88e-06 0.31
PPO2_AGABI PPO2 Polyphenol oxidase 2 4.968e-06 0.45
NEP_RABIT MME Neprilysin 5.391e-06 0.31
CP27B_MOUSE Cyp27b1 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial 5.7e-06 0.28
OXDA_HUMAN DAO D-amino-acid oxidase 6.689e-06 0.30
PPARA_HUMAN PPARA Peroxisome proliferator-activated receptor alpha 7.397e-06 0.39
S1PR2_HUMAN S1PR2 Sphingosine 1-phosphate receptor 2 7.56e-06 0.36
NRAM_I34A1 Neuraminidase 8.777e-06 0.32
MIF_HUMAN MIF Macrophage migration inhibitory factor 9.668e-06 0.30
HYES_MOUSE Ephx2 Bifunctional epoxide hydrolase 2 9.751e-06 0.38
GRM3_HUMAN GRM3 Metabotropic glutamate receptor 3 9.843e-06 0.34

Teriflunomide

PYRD_MOUSE Dhodh Dihydroorotate dehydrogenase (quinone), mitochondrial 6.616e-66 0.55
PYRD_RAT Dhodh Dihydroorotate dehydrogenase (quinone), mitochondrial 5.746e-65 0.55
RPGF3_HUMAN RAPGEF3 Rap guanine nucleotide exchange factor 3 1.288e-41 0.34
TRPM8_RAT Trpm8 Transient receptor potential cation channel subfamily M member 8 4.719e-41 0.39
RXFP1_HUMAN RXFP1 Relaxin receptor 1 8.493e-41 0.33
RPGF4_MOUSE Rapgef4 Rap guanine nucleotide exchange factor 4 1.064e-37 0.34
ADRB2_MOUSE Adrb2 Beta-2 adrenergic receptor 2.536e-37 0.32
HDAH_ALCSD hdaH Histone deacetylase-like amidohydrolase 1.272e-35 0.36
HYES_HUMAN EPHX2 Bifunctional epoxide hydrolase 2 2.93e-26 0.51
EHMT2_MOUSE Ehmt2 Histone-lysine N-methyltransferase EHMT2 3.656e-26 0.32
PSBA_MARPO psbA Photosystem II protein D1 1.106e-24 0.49
HYES_MOUSE Ephx2 Bifunctional epoxide hydrolase 2 2.255e-21 0.37
MYG_HUMAN MB Myoglobin 9.915e-19 0.36
ELOV6_HUMAN ELOVL6 Elongation of very long chain fatty acids protein 6 3.545e-18 0.31
EAA3_HUMAN SLC1A1 Excitatory amino acid transporter 3 3.676e-18 0.34
EAA2_HUMAN SLC1A2 Excitatory amino acid transporter 2 6.149e-18 0.34
TRPM8_HUMAN TRPM8 Transient receptor potential cation channel subfamily M member 8 1.024e-17 0.34
TRPV1_HUMAN TRPV1 Transient receptor potential cation channel subfamily V member 1 1.672e-17 0.51
TRPV1_RAT Trpv1 Transient receptor potential cation channel subfamily V member 1 3.247e-17 0.37
EAA4_RAT Slc1a6 Excitatory amino acid transporter 4 1.11e-16 0.32
PTPA_MYCTU ptpA Probable low molecular weight protein-tyrosine-phosphatase 1.11e-16 0.36
PSBA_SPIOL psbA Photosystem II protein D1 4.441e-15 0.49
QCR7_HUMAN UQCRB Cytochrome b-c1 complex subunit 7 4.441e-15 0.29
KIF11_HUMAN KIF11 Kinesin-like protein KIF11 8.948e-14 0.45
HYES_RAT Ephx2 Bifunctional epoxide hydrolase 2 1.075e-13 0.36
ACRO_HUMAN ACR Acrosin 1.422e-13 0.37
EAA1_HUMAN SLC1A3 Excitatory amino acid transporter 1 4.384e-13 0.32
TRPV4_RAT Trpv4 Transient receptor potential cation channel subfamily V member 4 1.597e-12 0.40
VGFR2_DANRE kdr Vascular endothelial growth factor receptor 2 1.42e-11 0.31
PYRD_HUMAN DHODH Dihydroorotate dehydrogenase (quinone), mitochondrial 4.831e-11 0.66
SORT_HUMAN SORT1 Sortilin 1.902e-10 0.30
TRPA1_RAT Trpa1 Transient receptor potential cation channel subfamily A member 1 2.074e-10 0.39
TRPV4_HUMAN TRPV4 Transient receptor potential cation channel subfamily V member 4 2.79e-10 0.40
KCNJ6_HUMAN KCNJ6 G protein-activated inward rectifier potassium channel 2 2.912e-10 0.37
AK1C3_HUMAN AKR1C3 Aldo-keto reductase family 1 member C3 2.93e-10 0.39
PDGFB_HUMAN PDGFB Platelet-derived growth factor subunit B 3.011e-10 0.28
Q6DMN0_TOXGO CPL Cathepsin L 3.807e-10 0.30
ELOV6_MOUSE Elovl6 Elongation of very long chain fatty acids protein 6 4.661e-10 0.29
KCNJ3_HUMAN KCNJ3 G protein-activated inward rectifier potassium channel 1 4.952e-10 0.39
SCNAA_RAT Scn10a Sodium channel protein type 10 subunit alpha 6.361e-10 0.33
KCJ11_HUMAN KCNJ11 ATP-sensitive inward rectifier potassium channel 11 9.24e-10 0.37
AK1C2_HUMAN AKR1C2 Aldo-keto reductase family 1 member C2 9.951e-10 0.39
PPARD_HUMAN PPARD Peroxisome proliferator-activated receptor delta 2.033e-09 0.34
ELOV3_HUMAN ELOVL3 Elongation of very long chain fatty acids protein 3 2.304e-09 0.29
APOB_HUMAN APOB Apolipoprotein B-100 3.339e-09 0.31
TRPA1_HUMAN TRPA1 Transient receptor potential cation channel subfamily A member 1 3.557e-09 0.35
PPARA_HUMAN PPARA Peroxisome proliferator-activated receptor alpha 3.682e-09 0.38
MCHR1_HUMAN MCHR1 Melanin-concentrating hormone receptor 1 5.235e-09 0.37
KCNJ5_HUMAN KCNJ5 G protein-activated inward rectifier potassium channel 4 6.425e-09 0.39
PPIA_RAT Ppia Peptidyl-prolyl cis-trans isomerase A 3.829e-08 0.35
NR1H4_HUMAN NR1H4 Bile acid receptor 4.22e-08 0.40
P2RY1_HUMAN P2RY1 P2Y purinoceptor 1 1.167e-07 0.34
ATF1_HUMAN ATF1 Cyclic AMP-dependent transcription factor ATF-1 2.017e-07 0.36
MDHC_HUMAN MDH1 Malate dehydrogenase, cytoplasmic 2.126e-07 0.37
KCNK9_HUMAN KCNK9 Potassium channel subfamily K member 9 2.519e-07 0.31
XBP1_HUMAN XBP1 X-box-binding protein 1 4.768e-07 0.40
S22A3_HUMAN SLC22A3 Solute carrier family 22 member 3 4.816e-07 0.33
EST2_HUMAN CES2 Cocaine esterase 7.767e-07 0.37
PRIO_SHEEP PRNP Major prion protein 8.63e-07 0.31
CAH12_HUMAN CA12 Carbonic anhydrase 12 1.204e-06 0.41
PLCB_HUMAN AGPAT2 1-acyl-sn-glycerol-3-phosphate acyltransferase beta 1.606e-06 0.30
TAAR1_RAT Taar1 Trace amine-associated receptor 1 1.77e-06 0.36
EBNA1_EBVB9 EBNA1 Epstein-Barr nuclear antigen 1 2.387e-06 0.31
SCN2A_RAT Scn2a Sodium channel protein type 2 subunit alpha 2.894e-06 0.34
PPARA_RAT Ppara Peroxisome proliferator-activated receptor alpha 3.746e-06 0.30
PASK_HUMAN PASK PAS domain-containing serine/threonine-protein kinase 4.586e-06 0.30
SCAF_HCMVA UL80 Capsid scaffolding protein 5.733e-06 0.31
PD2R2_HUMAN PTGDR2 Prostaglandin D2 receptor 2 8.544e-06 0.38
DCMC_HUMAN MLYCD Malonyl-CoA decarboxylase, mitochondrial 8.834e-06 0.37
P96878_MYCTU Probable transmembrane carbonic anhydrase (Carbonate dehydratase) (Carbonic dehydratase) 8.886e-06 0.41
MCHR1_RAT Mchr1 Melanin-concentrating hormone receptor 1 9.527e-06 0.31
S22A2_HUMAN SLC22A2 Solute carrier family 22 member 2 9.664e-06 0.33

Adrafinil

GP139_HUMAN GPR139 Probable G-protein coupled receptor 139 5.526e-65 0.34
Q94F81_MAIZE hda106 HD2 type histone deacetylase HDA106 5.123e-52 0.38
RCOR3_HUMAN RCOR3 REST corepressor 3 3.737e-47 0.38
ENPP2_MOUSE Enpp2 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 1.463e-44 0.34
ACER2_HUMAN ACER2 Alkaline ceramidase 2 6.889e-43 0.34
Q99P97_RAT Histone deacetylase 6 2.281e-40 0.32
CERT_HUMAN CERT1 Ceramide transfer protein 1.356e-39 0.31
NCS1_HUMAN NCS1 Neuronal calcium sensor 1 1.921e-39 0.31
Q9VWX8_DROME Frq2 FI18190p1 1.921e-39 0.31
Q9ZTP8_MAIZE hd1b Histone deacetylase 6.18e-36 0.38
AMPN_PIG ANPEP Aminopeptidase N 1.061e-32 0.39
BLAB_BACCE Metallo-beta-lactamase type 2 3.078e-31 0.35
DEF_STAAM def Peptide deformylase 3.72e-31 0.30
NEP_RABIT MME Neprilysin 3.368e-28 0.38
HDAC8_HUMAN HDAC8 Histone deacetylase 8 1.834e-26 0.45
AMP1_PLAFQ M1 family aminopeptidase 3.372e-24 0.36
Q9JN24_ECOLX def Peptide deformylase 2.045e-23 0.45
Q7K6A1_PLAF7 Histone deacetylase 2.07e-23 0.38
HDAC1_RAT Hdac1 Histone deacetylase 1 2.925e-23 0.30
CA2D1_RAT Cacna2d1 Voltage-dependent calcium channel subunit alpha-2/delta-1 1.699e-21 0.31
CACB1_RAT Cacnb1 Voltage-dependent L-type calcium channel subunit beta-1 3.802e-19 0.31
MANR_PSEPU mdlA Mandelate racemase 9.803e-19 0.30
HDAC1_HUMAN HDAC1 Histone deacetylase 1 3.239e-18 0.46
HDAC5_HUMAN HDAC5 Histone deacetylase 5 3.395e-18 0.44
CBPA3_HUMAN CPA3 Mast cell carboxypeptidase A 4.879e-18 0.29
EPHB_MYCTO Epoxide hydrolase B 4.879e-18 0.29
HDAC2_HUMAN HDAC2 Histone deacetylase 2 1.296e-17 0.44
MMP8_HUMAN MMP8 Neutrophil collagenase 2.036e-17 0.38
MMP3_HUMAN MMP3 Stromelysin-1 3.407e-17 0.38
FCER2_HUMAN FCER2 Low affinity immunoglobulin epsilon Fc receptor 2.22e-16 0.35
HDAC6_HUMAN HDAC6 Histone deacetylase 6 1.443e-15 0.45
PPAP_HUMAN ACP3 Prostatic acid phosphatase 1.776e-15 0.30
MMP1_HUMAN MMP1 Interstitial collagenase 2.109e-15 0.38
PA_I000X PA Polymerase acidic protein 2.887e-15 0.29
HDAC9_HUMAN HDAC9 Histone deacetylase 9 3.442e-15 0.44
HDAC1_MOUSE Hdac1 Histone deacetylase 1 4.774e-15 0.38
MMP2_HUMAN MMP2 72 kDa type IV collagenase 8.216e-15 0.38
HDAC7_HUMAN HDAC7 Histone deacetylase 7 1.01e-14 0.44
A5H660_SCHMA HDAC8 Histone deacetylase 8 2.021e-14 0.38
ACE_MOUSE Ace Angiotensin-converting enzyme 7.494e-14 0.30
EST1_RABIT Liver carboxylesterase 1 1.252e-13 0.34
MEP1B_HUMAN MEP1B Meprin A subunit beta 2.818e-13 0.34
MMP14_HUMAN MMP14 Matrix metalloproteinase-14 4.704e-13 0.36
VANX_ENTFC vanX D-alanyl-D-alanine dipeptidase 5.338e-13 0.28
CA2D1_MOUSE Cacna2d1 Voltage-dependent calcium channel subunit alpha-2/delta-1 5.98e-13 0.38
MMP7_HUMAN MMP7 Matrilysin 1.08e-12 0.38
BLA2_BACCE blm Metallo-beta-lactamase type 2 3.653e-12 0.35
NEP_RAT Mme Neprilysin 1.245e-11 0.36
MDM4_HUMAN MDM4 Protein Mdm4 1.651e-11 0.34
MMP9_HUMAN MMP9 Matrix metalloproteinase-9 1.667e-11 0.36
HDAC3_HUMAN HDAC3 Histone deacetylase 3 1.715e-11 0.39
AMPL_PIG LAP3 Cytosol aminopeptidase 1.801e-11 0.35
Q79MP6_PSEAI blaIMP-1 Beta-lactamase 4.262e-11 0.30
NCOR2_HUMAN NCOR2 Nuclear receptor corepressor 2 1.753e-10 0.38
NR0B1_HUMAN NR0B1 Nuclear receptor subfamily 0 group B member 1 2.006e-10 0.38
PA_I34A1 PA Polymerase acidic protein 3.15e-10 0.29
GRIK3_RAT Grik3 Glutamate receptor ionotropic, kainate 3 5.086e-10 0.31
CAC1B_RAT Cacna1b Voltage-dependent N-type calcium channel subunit alpha-1B 5.095e-10 0.31
AMPN_HUMAN ANPEP Aminopeptidase N 5.224e-10 0.36
MMP16_HUMAN MMP16 Matrix metalloproteinase-16 1.1e-09 0.32
CP51_MYCTU cyp51 Lanosterol 14-alpha demethylase 1.582e-09 0.30
AOX_TRYBB AOX Alternative oxidase, mitochondrial 1.645e-09 0.30
HDAC4_HUMAN HDAC4 Histone deacetylase 4 4.383e-09 0.44
AMD_HUMAN PAM Peptidyl-glycine alpha-amidating monooxygenase 4.608e-09 0.28
S15A2_RAT Slc15a2 Solute carrier family 15 member 2 7.149e-09 0.30
LPXC_ECOLI lpxC UDP-3-O-acyl-N-acetylglucosamine deacetylase 1.23e-08 0.35
CBPA1_BOVIN CPA1 Carboxypeptidase A1 1.564e-08 0.32
SCN2A_RAT Scn2a Sodium channel protein type 2 subunit alpha 2.334e-08 0.30
MMP12_HUMAN MMP12 Macrophage metalloelastase 4.173e-08 0.38
PSA_HUMAN NPEPPS Puromycin-sensitive aminopeptidase 1.41e-07 0.31
HDA10_HUMAN HDAC10 Polyamine deacetylase HDAC10 2.306e-07 0.38
THER_BACTH npr Thermolysin 2.54e-07 0.33
LKHA4_HUMAN LTA4H Leukotriene A-4 hydrolase 3.89e-07 0.38
NALD2_HUMAN NAALAD2 N-acetylated-alpha-linked acidic dipeptidase 2 3.93e-07 0.36
CBPB1_PIG CPB1 Carboxypeptidase B 4.905e-07 0.29
PHF8_HUMAN PHF8 Histone lysine demethylase PHF8 6.257e-07 0.29
EST2_HUMAN CES2 Cocaine esterase 7.124e-07 0.34
PPIA_RAT Ppia Peptidyl-prolyl cis-trans isomerase A 8.227e-07 0.29
HYES_RAT Ephx2 Bifunctional epoxide hydrolase 2 8.503e-07 0.34
CBPN_HUMAN CPN1 Carboxypeptidase N catalytic chain 9.396e-07 0.29
HDA11_HUMAN HDAC11 Histone deacetylase 11 2.049e-06 0.38
MMP12_MOUSE Mmp12 Macrophage metalloelastase 2.124e-06 0.28
EAA3_HUMAN SLC1A1 Excitatory amino acid transporter 3 3.94e-06 0.30
FNTB_HUMAN FNTB Protein farnesyltransferase subunit beta 3.998e-06 0.31
DXR_ECOLI dxr 1-deoxy-D-xylulose 5-phosphate reductoisomerase 4.966e-06 0.33
Q9XYC7_PLAFA HDAC1 Histone deacetylase 6.188e-06 0.38
HDAH_ALCSD hdaH Histone deacetylase-like amidohydrolase 8.201e-06 0.38
MMP13_HUMAN MMP13 Collagenase 3 9.274e-06 0.38
FNTA_HUMAN FNTA Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha 9.733e-06 0.31

Lurasidone

5HT1A_MOUSE Htr1a 5-hydroxytryptamine receptor 1A 4.799e-64 0.44
DRD2_MOUSE Drd2 D(2) dopamine receptor 3.705e-42 0.44
5HT1A_RAT Htr1a 5-hydroxytryptamine receptor 1A 3.317e-38 0.63
DRD2_RAT Drd2 D(2) dopamine receptor 1.489e-37 0.63
5HT2A_HUMAN HTR2A 5-hydroxytryptamine receptor 2A 2.545e-26 0.58
H10_HUMAN H1-0 Histone H1.0 2.944e-20 0.39
ADA1A_RAT Adra1a Alpha-1A adrenergic receptor 3.287e-19 0.41
DRD2_HUMAN DRD2 D(2) dopamine receptor 3.543e-19 0.58
5HT1A_HUMAN HTR1A 5-hydroxytryptamine receptor 1A 3.882e-18 0.58
5HT2A_RAT Htr2a 5-hydroxytryptamine receptor 2A 2.345e-17 0.49
GYRB_MYCSM gyrB DNA gyrase subunit B 2.665e-14 0.42
5HT7R_HUMAN HTR7 5-hydroxytryptamine receptor 7 3.557e-11 0.41
DRD3_HUMAN DRD3 D(3) dopamine receptor 4.973e-08 0.49
5HT2B_RAT Htr2b 5-hydroxytryptamine receptor 2B 6.632e-07 0.31
DHSO_HUMAN SORD Sorbitol dehydrogenase 2.884e-06 0.38
5HT6R_HUMAN HTR6 5-hydroxytryptamine receptor 6 5.638e-06 0.41

Salicylamide

KCMA1_HUMAN KCNMA1 Calcium-activated potassium channel subunit alpha-1 1.032e-60 0.42
PAR10_HUMAN PARP10 Protein mono-ADP-ribosyltransferase PARP10 2.157e-44 0.37
MGRA_STAAU mgrA HTH-type transcriptional regulator MgrA 1.096e-40 0.32
TCMO_HELTU CYP73A1 Trans-cinnamate 4-monooxygenase 1.921e-39 0.31
GSTA1_HUMAN GSTA1 Glutathione S-transferase A1 5.573e-39 0.43
NNMT_MOUSE Nnmt Nicotinamide N-methyltransferase 3.56e-37 0.29
RAGE_RAT Ager Advanced glycosylation end product-specific receptor 1.046e-36 0.29
MYOC_HUMAN MYOC Myocilin 7.502e-31 0.38
PARP1_HUMAN PARP1 Poly [ADP-ribose] polymerase 1 8.616e-30 0.48
STXA_SHIDY stxA Shiga toxin subunit A 3.238e-29 0.38
PAR15_HUMAN PARP15 Protein mono-ADP-ribosyltransferase PARP15 7.809e-29 0.32
TYRO_MOUSE Tyr Tyrosinase 1.09e-28 0.41
EST1_RABIT Liver carboxylesterase 1 2.411e-27 0.40
A0A072ZLE6_PSEAI mvfR LysR family transcriptional regulator 4.212e-27 0.38
HAOX1_MOUSE Hao1 Hydroxyacid oxidase 1 1.084e-26 0.38
HMGB1_HUMAN HMGB1 High mobility group protein B1 3.081e-26 0.32
DOPO_HUMAN DBH Dopamine beta-hydroxylase 4.048e-26 0.38
BLAB_BACCE Metallo-beta-lactamase type 2 1.914e-25 0.29
PARP2_HUMAN PARP2 Poly [ADP-ribose] polymerase 2 7.164e-24 0.33
RIR1_HUMAN RRM1 Ribonucleoside-diphosphate reductase large subunit 1.412e-23 0.34
NNMT_HUMAN NNMT Nicotinamide N-methyltransferase 8.083e-23 0.29
EST2_HUMAN CES2 Cocaine esterase 1.744e-20 0.40
KAT8_HUMAN KAT8 Histone acetyltransferase KAT8 3.462e-20 0.32
EPHB_MYCTO Epoxide hydrolase B 1.126e-18 0.30
PAR16_HUMAN PARP16 Protein mono-ADP-ribosyltransferase PARP16 1.11e-16 0.32
AOX_TRYBB AOX Alternative oxidase, mitochondrial 4.441e-16 0.52
LUXP_VIBHA luxP Autoinducer 2-binding periplasmic protein LuxP 6.772e-15 0.35
FADS1_HUMAN FADS1 Acyl-CoA (8-3)-desaturase 8.993e-15 0.37
KYNU_HUMAN KYNU Kynureninase 2.298e-14 0.31
Q5NGQ3_FRATT fabI Enoyl-[acyl-carrier-protein] reductase [NADH] 2.998e-14 0.35
Q9K2N0_PSEAI blaVIM-2 Beta-lactamase class B VIM-2 1.598e-13 0.36
LAT1_RAT Slc7a5 Large neutral amino acids transporter small subunit 1 1.704e-13 0.29
KCNN4_HUMAN KCNN4 Intermediate conductance calcium-activated potassium channel protein 4 4.421e-13 0.30
NCOA1_HUMAN NCOA1 Nuclear receptor coactivator 1 1.132e-12 0.38
CA2D1_MOUSE Cacna2d1 Voltage-dependent calcium channel subunit alpha-2/delta-1 1.597e-12 0.32
BXE_CLOBO botE Botulinum neurotoxin type E 3.497e-12 0.30
Q2PCB5_DICLA ca Carbonic anhydrase 8.327e-12 0.32
PARP1_RAT Parp1 Poly [ADP-ribose] polymerase 1 1.5e-11 0.30
GYRB_MYCSM gyrB DNA gyrase subunit B 1.664e-11 0.33
PB1_HUMAN PBRM1 Protein polybromo-1 2.15e-11 0.29
Q9NBA7_PLAFA Cysteine protease falcipain-3 2.276e-11 0.31
IKKB_HUMAN IKBKB Inhibitor of nuclear factor kappa-B kinase subunit beta 3.121e-11 0.41
H9B8T9_CAPHI CTSB Cathepsin B 6.279e-11 0.38
EST1_HUMAN CES1 Liver carboxylesterase 1 6.547e-11 0.40
Q3I4V7_CRYNV CAN2 Carbonic anhydrase 1.503e-10 0.32
KS6B1_HUMAN RPS6KB1 Ribosomal protein S6 kinase beta-1 4.923e-10 0.33
LOX15_HUMAN ALOX15 Arachidonate 15-lipoxygenase 7.287e-10 0.38
MP2K3_HUMAN MAP2K3 Dual specificity mitogen-activated protein kinase kinase 3 9.585e-10 0.33
CAH3_BOVIN CA3 Carbonic anhydrase 3 1.345e-09 0.42
PPIA_RAT Ppia Peptidyl-prolyl cis-trans isomerase A 3.726e-09 0.40
PARP4_HUMAN PARP4 Protein mono-ADP-ribosyltransferase PARP4 4.438e-09 0.28
AK1C2_HUMAN AKR1C2 Aldo-keto reductase family 1 member C2 4.708e-09 0.32
PAR14_HUMAN PARP14 Protein mono-ADP-ribosyltransferase PARP14 6.211e-09 0.32
PA2GX_HUMAN PLA2G10 Group 10 secretory phospholipase A2 6.915e-09 0.30
FPR1_HUMAN FPR1 fMet-Leu-Phe receptor 7.608e-09 0.31
PPO2_AGABI PPO2 Polyphenol oxidase 2 8.005e-09 0.38
GLD1_CAEEL gld-1 Female germline-specific tumor suppressor gld-1 8.199e-09 0.31
AK1C1_HUMAN AKR1C1 Aldo-keto reductase family 1 member C1 1.28e-08 0.29
CDC7_HUMAN CDC7 Cell division cycle 7-related protein kinase 1.645e-08 0.33
CAH14_HUMAN CA14 Carbonic anhydrase 14 5.113e-08 0.36
HPPD_PIG HPD 4-hydroxyphenylpyruvate dioxygenase 7.519e-08 0.29
Q6TUJ4_PSEAI blaIMP-1 Metallo beta-lactamase 1.031e-07 0.29
CISY2_YEAST CIT2 Citrate synthase, peroxisomal 1.07e-07 0.32
PAG_BACAN pagA Protective antigen 1.512e-07 0.47
POLG_DEN2P Genome polyprotein 1.578e-07 0.32
PARG_RAT Parg Poly(ADP-ribose) glycohydrolase 2.869e-07 0.28
C4YTQ8_CANAW ATP-dependent molecular chaperone HSP82 4.157e-07 0.46
SMCA4_HUMAN SMARCA4 Transcription activator BRG1 9.396e-07 0.29
CAN_CANAL NCE103 Carbonic anhydrase 1.556e-06 0.31
IKKA_HUMAN CHUK Inhibitor of nuclear factor kappa-B kinase subunit alpha 1.557e-06 0.35
PMYT1_HUMAN PKMYT1 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase 1.574e-06 0.33
TPA_HUMAN PLAT Tissue-type plasminogen activator 1.87e-06 0.44
AURKA_HUMAN AURKA Aurora kinase A 2.257e-06 0.33
Q7ZJM1_9HIV1 pol Integrase 2.279e-06 0.43
CAH9_HUMAN CA9 Carbonic anhydrase 9 2.472e-06 0.59
CYAA_BACAN cya Calmodulin-sensitive adenylate cyclase 2.473e-06 0.29
CAH7_HUMAN CA7 Carbonic anhydrase 7 2.652e-06 0.36
PPBI_HUMAN ALPI Intestinal-type alkaline phosphatase 3.144e-06 0.36
BLA2_BACCE blm Metallo-beta-lactamase type 2 7.112e-06 0.29
NF2L2_HUMAN NFE2L2 Nuclear factor erythroid 2-related factor 2 7.401e-06 0.34
CAH5B_HUMAN CA5B Carbonic anhydrase 5B, mitochondrial 7.609e-06 0.42
O69002_PSEAI pigA Biliverdin-producing heme oxygenase 7.884e-06 0.31
TCMO_POPKI CYP73A16 Trans-cinnamate 4-monooxygenase 7.884e-06 0.31
CAH3_HUMAN CA3 Carbonic anhydrase 3 9.16e-06 0.33

Triethylenetetramine

DHYS_RAT Dhps Deoxyhypusine synthase 1.394e-59 0.39
APAH_MYCRA aphA Acetylpolyamine amidohydrolase 2.397e-51 0.33
Q9GSW0_PLAFA dhs Deoxyhypusine synthase 1.947e-38 0.30
AGUA_STRMU aguA Putative agmatine deiminase 7.142e-37 0.29
PAO1_MAIZE MPAO1 Polyamine oxidase 1 3.151e-25 0.32
PAOX_HUMAN PAOX Peroxisomal N(1)-acetyl-spermine/spermidine oxidase 1.622e-21 0.35
CAH15_MOUSE Ca15 Carbonic anhydrase 15 5.972e-10 0.56
CAH3_HUMAN CA3 Carbonic anhydrase 3 2.352e-06 0.36
CAH13_MOUSE Ca13 Carbonic anhydrase 13 6.421e-06 0.36

Inositol_nicotinate

THAS_HUMAN TBXAS1 Thromboxane-A synthase 1.614e-58 0.40
ACHA6_MOUSE Chrna6 Neuronal acetylcholine receptor subunit alpha-6 1.425e-41 0.31
Q8WSF8_APLCA Soluble acetylcholine receptor 5.777e-41 0.37
CP1B1_HUMAN CYP1B1 Cytochrome P450 1B1 4.938e-40 0.44
ACHB3_MOUSE Chrnb3 Neuronal acetylcholine receptor subunit beta-3 3.583e-39 0.31
ACHA3_MOUSE Chrna3 Neuronal acetylcholine receptor subunit alpha-3 4.474e-39 0.31
CRTY_PANAN crtY Lycopene beta-cyclase 4.474e-39 0.31
ACHP_LYMST Acetylcholine-binding protein 3.405e-37 0.37
ACHA7_MOUSE Chrna7 Neuronal acetylcholine receptor subunit alpha-7 5.88e-37 0.31
GLRA1_RAT Glra1 Glycine receptor subunit alpha-1 9.628e-37 0.63
CP2A6_HUMAN CYP2A6 Cytochrome P450 2A6 7.342e-36 0.37
C11B1_BOVIN CYP11B1 Cytochrome P450 11B1, mitochondrial 1.812e-34 0.45
C11B2_HUMAN CYP11B2 Cytochrome P450 11B2, mitochondrial 3.56e-31 0.45
C11B1_HUMAN CYP11B1 Cytochrome P450 11B1, mitochondrial 2.75e-29 0.45
C11B1_RAT Cyp11b1 Cytochrome P450 11B1, mitochondrial 2.383e-27 0.45
ACHA7_RAT Chrna7 Neuronal acetylcholine receptor subunit alpha-7 3.849e-27 0.37
ACHA4_MOUSE Chrna4 Neuronal acetylcholine receptor subunit alpha-4 5.874e-26 0.31
ACHB2_HUMAN CHRNB2 Neuronal acetylcholine receptor subunit beta-2 2.567e-25 0.46
ACHA4_HUMAN CHRNA4 Neuronal acetylcholine receptor subunit alpha-4 2.454e-24 0.46
NAMPT_MOUSE Nampt Nicotinamide phosphoribosyltransferase 7.315e-24 0.29
ACHB2_RAT Chrnb2 Neuronal acetylcholine receptor subunit beta-2 1.817e-23 0.46
ACHA4_RAT Chrna4 Neuronal acetylcholine receptor subunit alpha-4 6.819e-23 0.46
ACHA7_HUMAN CHRNA7 Neuronal acetylcholine receptor subunit alpha-7 7.215e-23 0.37
H6TY12_PERAM Nicotinic acetylcholine receptor alpha8 subunit 1.324e-22 0.31
Q7M0F8_CAVPO Protein-glutamine gamma-glutamyltransferase, liver 2.222e-22 0.45
TGM2_HUMAN TGM2 Protein-glutamine gamma-glutamyltransferase 2 3.054e-22 0.39
ACHB4_MOUSE Chrnb4 Neuronal acetylcholine receptor subunit beta-4 5.335e-22 0.31
FA12_HUMAN F12 Coagulation factor XII 2.531e-21 0.34
ACHB2_MOUSE Chrnb2 Neuronal acetylcholine receptor subunit beta-2 1.429e-20 0.31
LDLR_HUMAN LDLR Low-density lipoprotein receptor 2.592e-19 0.34
KLK14_HUMAN KLK14 Kallikrein-14 1.523e-18 0.29
MMP2_MOUSE Mmp2 72 kDa type IV collagenase 6.785e-18 0.28
MMP9_MOUSE Mmp9 Matrix metalloproteinase-9 6.785e-18 0.28
KCNA5_HUMAN KCNA5 Potassium voltage-gated channel subfamily A member 5 2.292e-17 0.35
CP19A_HUMAN CYP19A1 Aromatase 2.921e-17 0.41
ISPH_AQUAE ispH 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 5.551e-16 0.30
MIP_LEGPN mip Outer membrane protein MIP 3.109e-15 0.39
ITPR3_BOVIN ITPR3 Inositol 1,4,5-trisphosphate receptor type 3 2.864e-14 0.46
CP17A_HUMAN CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase 4.285e-14 0.37
CYSP_PLAFA Trophozoite cysteine proteinase 8.56e-14 0.41
LEG9_HUMAN LGALS9 Galectin-9 1.095e-13 0.33
POLG_HRV16 Genome polyprotein 1.174e-13 0.30
PSA_HUMAN NPEPPS Puromycin-sensitive aminopeptidase 1.797e-13 0.29
LCAP_HUMAN LNPEP Leucyl-cystinyl aminopeptidase 2.979e-13 0.33
CCR9_HUMAN CCR9 C-C chemokine receptor type 9 4.001e-13 0.35
EST1_RABIT Liver carboxylesterase 1 9.357e-13 0.30
NAMPT_HUMAN NAMPT Nicotinamide phosphoribosyltransferase 1.106e-12 0.39
5HT3B_RAT Htr3b 5-hydroxytryptamine receptor 3B 1.791e-12 0.37
ACHB4_HUMAN CHRNB4 Neuronal acetylcholine receptor subunit beta-4 2.866e-12 0.46
ACHA3_HUMAN CHRNA3 Neuronal acetylcholine receptor subunit alpha-3 3.17e-12 0.46
VACHT_HUMAN SLC18A3 Vesicular acetylcholine transporter 3.891e-12 0.40
KLK5_HUMAN KLK5 Kallikrein-5 3.949e-12 0.29
RIR1_HUMAN RRM1 Ribonucleoside-diphosphate reductase large subunit 4.151e-12 0.33
ACHA_TETCF CHRNA1 Acetylcholine receptor subunit alpha 5.77e-12 0.33
PTAFR_CAVPO PTAFR Platelet-activating factor receptor 9.271e-12 0.41
LEG1_HUMAN LGALS1 Galectin-1 3.153e-11 0.33
GRP3_HUMAN RASGRP3 Ras guanyl-releasing protein 3 6.254e-11 0.30
KDM4D_HUMAN KDM4D Lysine-specific demethylase 4D 8.841e-11 0.33
HSP12_CAEEL hsp-16.2 Heat shock protein Hsp-16.2 1.517e-10 0.31
ACHA4_CHICK CHRNA4 Neuronal acetylcholine receptor subunit alpha-4 7.2e-10 0.31
ACHA9_RAT Chrna9 Neuronal acetylcholine receptor subunit alpha-9 7.2e-10 0.31
O96526_LEIMA CRK3 Cdc2-related kinase 9.181e-10 0.28
SC6A3_BOVIN SLC6A3 Sodium-dependent dopamine transporter 9.181e-10 0.28
GRM5_RAT Grm5 Metabotropic glutamate receptor 5 1.004e-09 0.35
HYES_RAT Ephx2 Bifunctional epoxide hydrolase 2 1.037e-09 0.39
AA2BR_MOUSE Adora2b Adenosine receptor A2b 1.076e-09 0.30
KLF5_HUMAN KLF5 Krueppel-like factor 5 1.099e-09 0.35
A9XFY4_MUSDO nAChRalpha5 Nicotinic acetylcholine receptor alpha 5 subunit 1.428e-09 0.33
5HT3A_RAT Htr3a 5-hydroxytryptamine receptor 3A 1.466e-09 0.37
ACHA3_RAT Chrna3 Neuronal acetylcholine receptor subunit alpha-3 2.795e-09 0.33
ACHB4_RAT Chrnb4 Neuronal acetylcholine receptor subunit beta-4 2.947e-09 0.33
PARP4_HUMAN PARP4 Protein mono-ADP-ribosyltransferase PARP4 3.055e-09 0.29
MMP25_HUMAN MMP25 Matrix metalloproteinase-25 4.226e-09 0.28
P3C2A_HUMAN PIK3C2A Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha 5.661e-09 0.36
SMS2_HUMAN SGMS2 Phosphatidylcholine:ceramide cholinephosphotransferase 2 7.778e-09 0.29
ABL1_HUMAN ABL1 Tyrosine-protein kinase ABL1 9.553e-09 0.35
MDR1_HUMAN ABCB1 ATP-dependent translocase ABCB1 1.205e-08 0.43
ACHG_HUMAN CHRNG Acetylcholine receptor subunit gamma 1.519e-08 0.33
PTAFR_HUMAN PTAFR Platelet-activating factor receptor 1.566e-08 0.31
ACHA5_HUMAN CHRNA5 Neuronal acetylcholine receptor subunit alpha-5 1.709e-08 0.30
VP16_HHV11 Tegument protein VP16 2.1e-08 0.34
ACHB_HUMAN CHRNB1 Acetylcholine receptor subunit beta 2.735e-08 0.33
ACHD_HUMAN CHRND Acetylcholine receptor subunit delta 3.949e-08 0.33
Q3Y5H1_9GAMC 3C-like protease 4.182e-08 0.44
TERA_HUMAN VCP Transitional endoplasmic reticulum ATPase 5.637e-08 0.32
FPPS_HUMAN FDPS Farnesyl pyrophosphate synthase 6.964e-08 0.33
AOC3_BOVIN AOC3 Membrane primary amine oxidase 6.978e-08 0.29
ACHA2_RAT Chrna2 Neuronal acetylcholine receptor subunit alpha-2 7.663e-08 0.33
STK11_HUMAN STK11 Serine/threonine-protein kinase STK11 1.41e-07 0.31
Q9WTR4_RAT Slc6a2 Transporter 1.629e-07 0.37
GSTO1_HUMAN GSTO1 Glutathione S-transferase omega-1 2.38e-07 0.30
MMP13_RAT Mmp13 Collagenase 3 2.68e-07 0.28
ALR_HUMAN GFER FAD-linked sulfhydryl oxidase ALR 3.203e-07 0.46
ACHA_HUMAN CHRNA1 Acetylcholine receptor subunit alpha 3.807e-07 0.33
GRM5_HUMAN GRM5 Metabotropic glutamate receptor 5 4.152e-07 0.39
Q0GKD7_LEIDO Farnesyl pyrophosphate synthase 4.73e-07 0.33
SC6A3_MACFA SLC6A3 Sodium-dependent dopamine transporter 5.622e-07 0.28
CP17A_RAT Cyp17a1 Steroid 17-alpha-hydroxylase/17,20 lyase 8.587e-07 0.35
KDM4E_HUMAN KDM4E Lysine-specific demethylase 4E 1.011e-06 0.29
SIR3_HUMAN SIRT3 NAD-dependent protein deacetylase sirtuin-3, mitochondrial 1.421e-06 0.35
ACHB3_RAT Chrnb3 Neuronal acetylcholine receptor subunit beta-3 1.653e-06 0.31
ADRM1_HUMAN ADRM1 Proteasomal ubiquitin receptor ADRM1 1.683e-06 0.29
PRS10_HUMAN PSMC6 26S proteasome regulatory subunit 10B 1.683e-06 0.29
PRS4_HUMAN PSMC1 26S proteasome regulatory subunit 4 1.683e-06 0.29
PRS6A_HUMAN PSMC3 26S proteasome regulatory subunit 6A 1.683e-06 0.29
PRS6B_HUMAN PSMC4 26S proteasome regulatory subunit 6B 1.683e-06 0.29
PRS7_HUMAN PSMC2 26S proteasome regulatory subunit 7 1.683e-06 0.29
PRS8_HUMAN PSMC5 26S proteasome regulatory subunit 8 1.683e-06 0.29
PSD11_HUMAN PSMD11 26S proteasome non-ATPase regulatory subunit 11 1.683e-06 0.29
PSD12_HUMAN PSMD12 26S proteasome non-ATPase regulatory subunit 12 1.683e-06 0.29
PSD13_HUMAN PSMD13 26S proteasome non-ATPase regulatory subunit 13 1.683e-06 0.29
PSMD1_HUMAN PSMD1 26S proteasome non-ATPase regulatory subunit 1 1.683e-06 0.29
PSMD2_HUMAN PSMD2 26S proteasome non-ATPase regulatory subunit 2 1.683e-06 0.29
PSMD3_HUMAN PSMD3 26S proteasome non-ATPase regulatory subunit 3 1.683e-06 0.29
PSMD4_HUMAN PSMD4 26S proteasome non-ATPase regulatory subunit 4 1.683e-06 0.29
PSMD6_HUMAN PSMD6 26S proteasome non-ATPase regulatory subunit 6 1.683e-06 0.29
PSMD7_HUMAN PSMD7 26S proteasome non-ATPase regulatory subunit 7 1.683e-06 0.29
PSMD8_HUMAN PSMD8 26S proteasome non-ATPase regulatory subunit 8 1.683e-06 0.29
SEM1_HUMAN SEM1 26S proteasome complex subunit SEM1 1.683e-06 0.29
EST2_HUMAN CES2 Cocaine esterase 1.735e-06 0.30
CP3A4_HUMAN CYP3A4 Cytochrome P450 3A4 1.818e-06 0.48
MMP12_MOUSE Mmp12 Macrophage metalloelastase 1.88e-06 0.28
POLG_HCV77 Genome polyprotein 1.942e-06 0.37
NEMO_HUMAN IKBKG NF-kappa-B essential modulator 2.128e-06 0.31
P4HTM_HUMAN P4HTM Transmembrane prolyl 4-hydroxylase 2.433e-06 0.29
EFC4B_HUMAN CRACR2A EF-hand calcium-binding domain-containing protein 4B 2.687e-06 0.33
LEG3_HUMAN LGALS3 Galectin-3 3.433e-06 0.33
ACH4_DROME nAChRbeta2 Acetylcholine receptor subunit beta-like 2 4.088e-06 0.31
NCOA1_HUMAN NCOA1 Nuclear receptor coactivator 1 4.09e-06 0.30
TBA1A_PIG TUBA1A Tubulin alpha-1A chain 4.793e-06 0.39
SIR2_HUMAN SIRT2 NAD-dependent protein deacetylase sirtuin-2 5.053e-06 0.55
CCNA2_HUMAN CCNA2 Cyclin-A2 5.721e-06 0.37
HDAC1_HUMAN HDAC1 Histone deacetylase 1 6.857e-06 0.41
STABP_HUMAN STAMBP STAM-binding protein 8.622e-06 0.29
TA2R_RAT Tbxa2r Thromboxane A2 receptor 9.728e-06 0.38

Iopanoic_acid

GSH1_HUMAN GCLC Glutamate--cysteine ligase catalytic subunit 3.007e-57 0.35
TY3H_RAT Th Tyrosine 3-monooxygenase 1.921e-39 0.31
S22AK_MOUSE Slc22a20 Solute carrier family 22 member 20 7.875e-29 0.33
SO1C1_MOUSE Slco1c1 Solute carrier organic anion transporter family member 1C1 4.179e-25 0.31
TY3H_HUMAN TH Tyrosine 3-monooxygenase 1.193e-19 0.31
SO4C1_HUMAN SLCO4C1 Solute carrier organic anion transporter family member 4C1 5.19e-19 0.30
PPARA_HUMAN PPARA Peroxisome proliferator-activated receptor alpha 7.437e-08 0.32
CBPB1_PIG CPB1 Carboxypeptidase B 4.905e-07 0.29
PPARD_HUMAN PPARD Peroxisome proliferator-activated receptor delta 8.545e-06 0.30

Gabapentin_enacarbil

O77773_PIG Voltage-dependent calcium channel alpha-2 delta subunit 2.074e-56 0.45
CA2D1_RAT Cacna2d1 Voltage-dependent calcium channel subunit alpha-2/delta-1 1.463e-08 0.45

Acetylcarnitine

MCAT_HUMAN SLC25A20 Mitochondrial carnitine/acylcarnitine carrier protein 7.954e-51 0.40
Q8VH27_CAVPO GPM2 Muscarinic acetylcholine receptor 2.701e-06 0.37

Chloramphenicol_succinate

GLO2_RAT Hagh Hydroxyacylglutathione hydrolase, mitochondrial 2.663e-50 0.34
UBE2B_HUMAN UBE2B Ubiquitin-conjugating enzyme E2 B 7.142e-37 0.29
MYOC_HUMAN MYOC Myocilin 7.498e-24 0.29
MEP2_YEAST MEP2 Ammonium transporter MEP2 1.66e-10 0.31
SC6A3_BOVIN SLC6A3 Sodium-dependent dopamine transporter 7.541e-10 0.29
S22A6_RAT Slc22a6 Solute carrier family 22 member 6 5.378e-09 0.34
STXA_SHIDY stxA Shiga toxin subunit A 1.867e-08 0.30
PHLP2_HUMAN PHLPP2 PH domain leucine-rich repeat-containing protein phosphatase 2 1.365e-07 0.28
METC_ECOLI metC Cystathionine beta-lyase MetC 2.68e-07 0.28

Nandrolone_decanoate

S5A2_HUMAN SRD5A2 3-oxo-5-alpha-steroid 4-dehydrogenase 2 2.621e-47 0.43
SHBG_HUMAN SHBG Sex hormone-binding globulin 1.158e-43 0.44
S22A3_RAT Slc22a3 Solute carrier family 22 member 3 8.192e-42 0.36
DHB7_HUMAN HSD17B7 3-keto-steroid reductase 9.805e-40 0.34
TAT_HV112 tat Protein Tat 8.095e-39 0.34
CBG_HUMAN SERPINA6 Corticosteroid-binding globulin 1.028e-34 0.37
Q690N0_BOVIN PGR Progesterone receptor 8.979e-31 0.44
SO1A1_RAT Slco1a1 Solute carrier organic anion transporter family member 1A1 1.229e-30 0.37
S5A1_HUMAN SRD5A1 3-oxo-5-alpha-steroid 4-dehydrogenase 1 1.44e-28 0.43
S22A2_RAT Slc22a2 Solute carrier family 22 member 2 1.35e-24 0.36
F1Q298_CANLF NR3C1 Glucocorticoid receptor 3.914e-24 0.30
GCR_PIG NR3C1 Glucocorticoid receptor 3.914e-24 0.30
PRGR_RABIT PGR Progesterone receptor 1.139e-22 0.52
Q862F3_BOVIN Similar to alpha-tubulin isoform 1 3.238e-21 0.38
ANDR_RAT Ar Androgen receptor 3.241e-21 0.52
ADCYA_HUMAN ADCY10 Adenylate cyclase type 10 1.146e-20 0.33
PRGR_RAT Pgr Progesterone receptor 4.082e-20 0.45
3BHS1_HUMAN HSD3B1 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 5.403e-20 0.31
ANDR_HUMAN AR Androgen receptor 1.649e-19 0.52
AT2A1_HUMAN ATP2A1 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 1.69e-19 0.30
3BHS_MYCTU 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase 1.126e-18 0.30
TBB2B_BOVIN TUBB2B Tubulin beta-2B chain 1.738e-17 0.38
PRGR_HUMAN PGR Progesterone receptor 2.764e-17 0.51
KPCA_RAT Prkca Protein kinase C alpha type 3.331e-16 0.32
CP19A_HUMAN CYP19A1 Aromatase 1.121e-14 0.48
DHI2_HUMAN HSD11B2 Corticosteroid 11-beta-dehydrogenase isozyme 2 1.199e-14 0.32
S22A3_HUMAN SLC22A3 Solute carrier family 22 member 3 7.616e-14 0.35
DHI2_MOUSE Hsd11b2 Corticosteroid 11-beta-dehydrogenase isozyme 2 1.492e-13 0.30
STS_HUMAN STS Steryl-sulfatase 2.429e-11 0.35
FABPL_RAT Fabp1 Fatty acid-binding protein, liver 4.051e-11 0.35
Q4QYD9_RAT Heat sensitive channel TRPV3 1.381e-10 0.36
MRP4_HUMAN ABCC4 Multidrug resistance-associated protein 4 2.015e-10 0.30
TRPV4_MOUSE Trpv4 Transient receptor potential cation channel subfamily V member 4 2.244e-10 0.30
ANDR_MOUSE Ar Androgen receptor 2.595e-10 0.52
S22A1_HUMAN SLC22A1 Solute carrier family 22 member 1 9.951e-10 0.35
ERG2_YEAST ERG2 C-8 sterol isomerase 2.298e-09 0.37
AT2A1_RABIT ATP2A1 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 4.427e-09 0.30
MCR_HUMAN NR3C2 Mineralocorticoid receptor 1.281e-08 0.42
LASR_PSEAE lasR Transcriptional activator protein LasR 2.878e-08 0.29
CP17A_HUMAN CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase 8.543e-08 0.52
Q9RMS5_PSEAI phzR LuxR family transcriptional regulator 2.362e-07 0.29
LSS_RAT Lss Lanosterol synthase 2.551e-06 0.30
SO1B1_HUMAN SLCO1B1 Solute carrier organic anion transporter family member 1B1 2.648e-06 0.29

Gadoxetic_acid

KLK1_HUMAN KLK1 Kallikrein-1 9.288e-42 0.33
KLKB1_HUMAN KLKB1 Plasma kallikrein 2.642e-41 0.33
ACACB_HUMAN ACACB Acetyl-CoA carboxylase 2 7.998e-20 0.41
CBPA1_HUMAN CPA1 Carboxypeptidase A1 1.494e-17 0.32
LOX15_RAT Alox15 Arachidonate 15-lipoxygenase 3.244e-17 0.32
PPARA_HUMAN PPARA Peroxisome proliferator-activated receptor alpha 5.551e-16 0.37
A0A0Y9T855_PLABE DHODH Dihydroorotate dehydrogenase (quinone), mitochondrial 2.753e-14 0.31
A5K1N1_PLAVS Dihydroorotate dehydrogenase, mitochondrial, putative 2.753e-14 0.31
ACE2_HUMAN ACE2 Angiotensin-converting enzyme 2 6.961e-14 0.31
OPRM_MACMU OPRM1 Mu-type opioid receptor 9.837e-14 0.34
FFAR1_HUMAN FFAR1 Free fatty acid receptor 1 4.472e-12 0.34
PPARD_HUMAN PPARD Peroxisome proliferator-activated receptor delta 5.44e-12 0.34
PPARG_HUMAN PPARG Peroxisome proliferator-activated receptor gamma 7.315e-12 0.35
LPXC_AQUAE lpxC UDP-3-O-acyl-N-acetylglucosamine deacetylase 1.554e-11 0.31
KIFC1_HUMAN KIFC1 Kinesin-like protein KIFC1 7.407e-11 0.29
LKHA4_HUMAN LTA4H Leukotriene A-4 hydrolase 1.643e-09 0.34
CAH4_BOVIN CA4 Carbonic anhydrase 4 2.433e-09 0.33
PPARA_RAT Ppara Peroxisome proliferator-activated receptor alpha 6.628e-09 0.30
DHB3_RAT Hsd17b3 Testosterone 17-beta-dehydrogenase 3 9.145e-08 0.30
PPARA_MOUSE Ppara Peroxisome proliferator-activated receptor alpha 1.312e-07 0.33
ERG2_YEAST ERG2 C-8 sterol isomerase 1.823e-07 0.28
Q9RMS5_PSEAI phzR LuxR family transcriptional regulator 2.105e-07 0.29
CAH4_HUMAN CA4 Carbonic anhydrase 4 6.577e-07 0.33
EBP_HUMAN EBP 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase 2.079e-06 0.28
LOX5_RAT Alox5 Arachidonate 5-lipoxygenase 3.96e-06 0.38

Dichloroacetic_acid

AL1A2_CHICK ALDH1A2 Retinal dehydrogenase 2 3.824e-40 0.32
AAA1_RAT Slc7a10 Asc-type amino acid transporter 1 7.545e-40 0.32
EAA4_RAT Slc1a6 Excitatory amino acid transporter 4 1.11e-16 0.32
AL1A3_HUMAN ALDH1A3 Aldehyde dehydrogenase family 1 member A3 8.327e-12 0.32
AMPB_HUMAN RNPEP Aminopeptidase B 6.878e-11 0.29
AL1A2_HUMAN ALDH1A2 Retinal dehydrogenase 2 4.011e-10 0.32

Riociguat

BUB1_HUMAN BUB1 Mitotic checkpoint serine/threonine-protein kinase BUB1 3.372e-36 0.35
P85A_HUMAN PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha 2.58e-21 0.34
MK03_MOUSE Mapk3 Mitogen-activated protein kinase 3 4.627e-20 0.31
AAAT_HUMAN SLC1A5 Neutral amino acid transporter B(0) 6.772e-15 0.28
Q7ZJM1_9HIV1 pol Integrase 1.432e-14 0.34
Q9BJF5_TOXGO CDPK1 Calmodulin-domain protein kinase 1 9.681e-14 0.35
PK3CG_HUMAN PIK3CG Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 7.779e-12 0.34
PK3CD_HUMAN PIK3CD Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 1.194e-11 0.34
PAR15_HUMAN PARP15 Protein mono-ADP-ribosyltransferase PARP15 5.575e-10 0.29
Q9Z1J7_RAT Slc1a5 Amino acid transporter 9.852e-10 0.28
MK01_MOUSE Mapk1 Mitogen-activated protein kinase 1 1.149e-09 0.32
AA1R_HUMAN ADORA1 Adenosine receptor A1 2.321e-09 0.38
PANK1_HUMAN PANK1 Pantothenate kinase 1 7.791e-09 0.31
AA2AR_HUMAN ADORA2A Adenosine receptor A2a 8.298e-09 0.38
B9W6M3_CANDC CNA1 Serine/threonine-protein phosphatase 2.247e-08 0.29
KCNK3_HUMAN KCNK3 Potassium channel subfamily K member 3 5.357e-08 0.31
NK3R_HUMAN TACR3 Neuromedin-K receptor 9.266e-08 0.32
AA1R_BOVIN ADORA1 Adenosine receptor A1 2.768e-07 0.31
ENPP2_HUMAN ENPP2 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 6.308e-07 0.36
PD2R2_MOUSE Ptgdr2 Prostaglandin D2 receptor 2 1.03e-06 0.30
KPYM_HUMAN PKM Pyruvate kinase PKM 1.233e-06 0.33

Glibornuride

LN28A_MOUSE Lin28a Protein lin-28 homolog A 1.609e-35 0.28
Q9TU16_CANLF PTGER4 Prostaglandin E receptor 4 1.246e-25 0.32
FFAR4_RAT Ffar4 Free fatty acid receptor 4 2.22e-16 0.31
FPR1_HUMAN FPR1 fMet-Leu-Phe receptor 5.995e-15 0.31
F16P1_HUMAN FBP1 Fructose-1,6-bisphosphatase 1 1.01e-13 0.37
ABCBB_RAT Abcb11 Bile salt export pump 9.847e-13 0.31
TASP1_HUMAN TASP1 Threonine aspartase 1 1.686e-12 0.34
S15A2_RAT Slc15a2 Solute carrier family 15 member 2 2.568e-09 0.31
METC_ECOLI metC Cystathionine beta-lyase MetC 1.881e-08 0.33
S22A6_RAT Slc22a6 Solute carrier family 22 member 6 2.408e-08 0.31
PLCG1_HUMAN PLCG1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 4.063e-08 0.32
S12A2_HUMAN SLC12A2 Solute carrier family 12 member 2 9.381e-08 0.33
STS_HUMAN STS Steryl-sulfatase 9.471e-08 0.35
PPBT_BOVIN ALPL Alkaline phosphatase, tissue-nonspecific isozyme 1.612e-07 0.31
PE2R4_HUMAN PTGER4 Prostaglandin E2 receptor EP4 subtype 6.048e-07 0.33
S12A5_HUMAN SLC12A5 Solute carrier family 12 member 5 7.334e-06 0.33
TA2R_HUMAN TBXA2R Thromboxane A2 receptor 8.369e-06 0.35
VIPR2_HUMAN VIPR2 Vasoactive intestinal polypeptide receptor 2 9.278e-06 0.30

Dimethyl_fumarate

GFPT1_HUMAN GFPT1 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 8.071e-28 0.45
PAR15_HUMAN PARP15 Protein mono-ADP-ribosyltransferase PARP15 6.526e-13 0.38
AOFB_MOUSE Maob Amine oxidase [flavin-containing] B 3.036e-08 0.32
TLR4_MOUSE Tlr4 Toll-like receptor 4 3.35e-07 0.36
HCAR2_HUMAN HCAR2 Hydroxycarboxylic acid receptor 2 1.165e-06 0.76
T23O_MOUSE Tdo2 Tryptophan 2,3-dioxygenase 2.044e-06 0.32
AMPL_HUMAN LAP3 Cytosol aminopeptidase 2.231e-06 0.48
PAR14_HUMAN PARP14 Protein mono-ADP-ribosyltransferase PARP14 6.508e-06 0.38

Hydroxyproline

PYR1_HUMAN CAD CAD protein 5.245e-27 0.33
GRIK1_HUMAN GRIK1 Glutamate receptor ionotropic, kainate 1 3.142e-24 0.33
GRIK1_RAT Grik1 Glutamate receptor ionotropic, kainate 1 3.331e-16 0.42
Q9Z1J7_RAT Slc1a5 Amino acid transporter 5.532e-13 0.38
GRIK3_RAT Grik3 Glutamate receptor ionotropic, kainate 3 1.755e-08 0.42
GRIA3_HUMAN GRIA3 Glutamate receptor 3 2.571e-07 0.31
GRIK3_HUMAN GRIK3 Glutamate receptor ionotropic, kainate 3 6.531e-07 0.31
GRIA2_HUMAN GRIA2 Glutamate receptor 2 3.737e-06 0.31
GRIK5_HUMAN GRIK5 Glutamate receptor ionotropic, kainate 5 4.685e-06 0.31
S6A12_MOUSE Slc6a12 Sodium- and chloride-dependent betaine transporter 5.567e-06 0.28

Isoxicam

PFKA_TRYCC pfk ATP-dependent 6-phosphofructokinase 8.871e-27 0.33
PFKA_TRYBB pfk ATP-dependent 6-phosphofructokinase 4.544e-21 0.33
KS6A2_HUMAN RPS6KA2 Ribosomal protein S6 kinase alpha-2 3.095e-17 0.36
SMN_HUMAN SMN1; SMN2 Survival motor neuron protein 1.11e-16 0.31
PPIA_HUMAN PPIA Peptidyl-prolyl cis-trans isomerase A 2.562e-12 0.33
STIM1_RAT Stim1 Stromal interaction molecule 1 3.104e-12 0.30
PVDQ_PSEAE pvdQ Acyl-homoserine lactone acylase PvdQ 5.464e-12 0.45
STIM1_HUMAN STIM1 Stromal interaction molecule 1 1.362e-11 0.30
CRCM1_HUMAN ORAI1 Calcium release-activated calcium channel protein 1 1.498e-10 0.30
PRIO_HUMAN PRNP Major prion protein 2.102e-09 0.37
CRCM1_RAT Orai1 Calcium release-activated calcium channel protein 1 7.463e-08 0.30
S22A8_HUMAN SLC22A8 Solute carrier family 22 member 8 5.114e-07 0.35
ACM1_RAT Chrm1 Muscarinic acetylcholine receptor M1 1.451e-06 0.33
LUCI_AQULA Luciferin 4-monooxygenase 4.23e-06 0.30
KDM3A_HUMAN KDM3A Lysine-specific demethylase 3A 4.244e-06 0.32
HS90B_HUMAN HSP90AB1 Heat shock protein HSP 90-beta 4.878e-06 0.31
Q6UCJ9_TOXGO ENR Enoyl-acyl carrier reductase 5.897e-06 0.36
KDM4D_HUMAN KDM4D Lysine-specific demethylase 4D 6.209e-06 0.32

Iotroxic_acid

TPMT_HUMAN TPMT Thiopurine S-methyltransferase 2.128e-24 0.33

Isoaminile

ERG2_YEAST ERG2 C-8 sterol isomerase 2.66e-17 0.52
EBP_HUMAN EBP 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase 9.326e-15 0.52
KCNN4_HUMAN KCNN4 Intermediate conductance calcium-activated potassium channel protein 4 8.836e-08 0.34

Deferiprone

COMT_HUMAN COMT Catechol O-methyltransferase 5.7e-10 0.52
DOPO_HUMAN DBH Dopamine beta-hydroxylase 1.89e-09 0.36
TLR1_MOUSE Tlr1 Toll-like receptor 1 3.18e-06 0.32
TLR2_MOUSE Tlr2 Toll-like receptor 2 3.18e-06 0.32

Azapropazone

AADAT_RAT Aadat Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial 3.985e-08 0.29

Viomycin

NAAA_HUMAN NAAA N-acylethanolamine-hydrolyzing acid amidase 1.441e-07 0.29
ADAM8_HUMAN ADAM8 Disintegrin and metalloproteinase domain-containing protein 8 8.254e-07 0.30