Results of Job: search_f377c713-59b0-4c8a-a194-82bedea30e23

Query Target Key Target Name Description P-Value MaxTC

Dapagliflozin

SC5A2_HUMAN SLC5A2 Sodium/glucose cotransporter 2 0 1.00
SC5A1_HUMAN SLC5A1 Sodium/glucose cotransporter 1 7.792e-191 1.00
SC5A4_HUMAN SLC5A4 Solute carrier family 5 member 4 1.868e-123 1.00
SC5AB_HUMAN SLC5A11 Sodium/myo-inositol cotransporter 2 2.714e-79 1.00
SC5A2_RAT Slc5a2 Sodium/glucose cotransporter 2 5.407e-65 1.00
SC5A2_MOUSE Slc5a2 Sodium/glucose cotransporter 2 1.304e-197 0.82
FIMH_ECOLI fimH Type 1 fimbrin D-mannose specific adhesin 9.229e-120 0.37
ADK_TOXGO AK Adenosine kinase 3.652e-63 0.34
S28A2_HUMAN SLC28A2 Sodium/nucleoside cotransporter 2 1.822e-48 0.33
SC5A1_RAT Slc5a1 Sodium/glucose cotransporter 1 2.048e-46 0.30
B4GT1_BOVIN B4GALT1 Beta-1,4-galactosyltransferase 1 1.367e-45 0.31
GGTA1_PIG GGTA1 N-acetyllactosaminide alpha-1,3-galactosyltransferase 8.297e-37 0.29
RASN_HUMAN NRAS GTPase NRas 8.297e-37 0.29
S28A2_RAT Slc28a2 Sodium/nucleoside cotransporter 2 1.007e-35 0.28
B4EH87_BURCJ Lectin 3.296e-34 0.37
PYGM_RABIT PYGM Glycogen phosphorylase, muscle form 1.525e-31 0.37
TYRO_HUMAN TYR Tyrosinase 3.087e-27 0.34
ADA_MOUSE Ada Adenosine deaminase 1.239e-23 0.29
S29A1_RAT Slc29a1 Equilibrative nucleoside transporter 1 4.035e-23 0.28
AA1R_CHICK ADORA1 Adenosine receptor A1 2.241e-21 0.30
IL2_HUMAN IL2 Interleukin-2 2.589e-21 0.32
S29A1_HUMAN SLC29A1 Equilibrative nucleoside transporter 1 1.52e-20 0.34
LEG9_HUMAN LGALS9 Galectin-9 3.294e-18 0.29
B4GT1_HUMAN B4GALT1 Beta-1,4-galactosyltransferase 1 8.104e-18 0.28
ADOK_MYCTO adoK Adenosine kinase 1.561e-17 0.31
FGF1_HUMAN FGF1 Fibroblast growth factor 1 1.11e-16 0.29
Q9QXI6_MOUSE Slc5a1 SGLT1 protein 6.661e-16 0.35
BIP_HUMAN HSPA5 Endoplasmic reticulum chaperone BiP 2.665e-15 0.34
AA1R_RAT Adora1 Adenosine receptor A1 7.572e-14 0.34
FGF2_HUMAN FGF2 Fibroblast growth factor 2 1.14e-13 0.29
A0A0Y9T855_PLABE DHODH Dihydroorotate dehydrogenase (quinone), mitochondrial 3.164e-13 0.29
A5K1N1_PLAVS Dihydroorotate dehydrogenase, mitochondrial, putative 3.164e-13 0.29
AL1B1_HUMAN ALDH1B1 Aldehyde dehydrogenase X, mitochondrial 1.208e-10 0.31
LPXC_AQUAE lpxC UDP-3-O-acyl-N-acetylglucosamine deacetylase 1.336e-10 0.28
PGH2_RAT Ptgs2 Prostaglandin G/H synthase 2 1.464e-10 0.36
VEGFA_HUMAN VEGFA Vascular endothelial growth factor A 4.758e-10 0.29
AL1A2_HUMAN ALDH1A2 Retinal dehydrogenase 2 6.6e-10 0.31
AA2AR_RAT Adora2a Adenosine receptor A2a 8.402e-10 0.34
HSP7C_HUMAN HSPA8 Heat shock cognate 71 kDa protein 9.468e-10 0.34
LYAM1_HUMAN SELL L-selectin 2.351e-09 0.31
RASH_HUMAN HRAS GTPase HRas 3.553e-08 0.31
LYAG_MOUSE Gaa Lysosomal alpha-glucosidase 4.208e-08 0.32
ADRB2_RAT Adrb2 Beta-2 adrenergic receptor 7.597e-08 0.30
Q9RMS5_PSEAI phzR LuxR family transcriptional regulator 9.412e-08 0.30
IL6_HUMAN IL6 Interleukin-6 1.895e-07 0.29
CDD_MOUSE Cda Cytidine deaminase 3.884e-07 0.29
PGH1_RAT Ptgs1 Prostaglandin G/H synthase 1 4.905e-07 0.29
CDD_HUMAN CDA Cytidine deaminase 2.32e-06 0.29
AA3R_RABIT ADORA3 Adenosine receptor A3 2.473e-06 0.29
KLK1_HUMAN KLK1 Kallikrein-1 3.637e-06 0.30
AA1R_RABIT ADORA1 Adenosine receptor A1 4.01e-06 0.29
AA3R_RAT Adora3 Adenosine receptor A3 5.354e-06 0.31

Vandetanib

EPHA2_HUMAN EPHA2 Ephrin type-A receptor 2 1.407e-307 1.00
EPHB4_HUMAN EPHB4 Ephrin type-B receptor 4 2.633e-243 1.00
EGFR_HUMAN EGFR Epidermal growth factor receptor 2.737e-239 1.00
VGFR2_HUMAN KDR Vascular endothelial growth factor receptor 2 1.579e-135 1.00
ERBB2_HUMAN ERBB2 Receptor tyrosine-protein kinase erbB-2 8.468e-118 1.00
PGFRB_HUMAN PDGFRB Platelet-derived growth factor receptor beta 1.58e-95 1.00
ERBB4_HUMAN ERBB4 Receptor tyrosine-protein kinase erbB-4 1.044e-76 1.00
VGFR1_HUMAN FLT1 Vascular endothelial growth factor receptor 1 1.178e-72 1.00
RET_HUMAN RET Proto-oncogene tyrosine-protein kinase receptor Ret 2.133e-63 1.00
TBA1A_RAT Tuba1a Tubulin alpha-1A chain 1.778e-49 1.00
ERBB3_HUMAN ERBB3 Receptor tyrosine-protein kinase erbB-3 4.709e-48 1.00
SRC_HUMAN SRC Proto-oncogene tyrosine-protein kinase Src 1.51e-42 1.00
MK06_HUMAN MAPK6 Mitogen-activated protein kinase 6 2.403e-40 1.00
HUNK_HUMAN HUNK Hormonally up-regulated neu tumor-associated kinase 7.775e-35 1.00
CTRO_HUMAN CIT Citron Rho-interacting kinase 4.956e-34 1.00
COQ8A_HUMAN COQ8A Atypical kinase COQ8A, mitochondrial 3.469e-33 1.00
EPHB6_HUMAN EPHB6 Ephrin type-B receptor 6 5.923e-33 1.00
EPHA6_HUMAN EPHA6 Ephrin type-A receptor 6 9.491e-33 1.00
STK10_HUMAN STK10 Serine/threonine-protein kinase 10 1.151e-32 1.00
EPHA8_HUMAN EPHA8 Ephrin type-A receptor 8 1.2e-32 1.00
MRCKG_HUMAN CDC42BPG Serine/threonine-protein kinase MRCK gamma 1.58e-31 1.00
ST32A_HUMAN STK32A Serine/threonine-protein kinase 32A 1.58e-31 1.00
MP2K5_HUMAN MAP2K5 Dual specificity mitogen-activated protein kinase kinase 5 1.063e-30 1.00
COQ8B_HUMAN COQ8B Atypical kinase COQ8B, mitochondrial 4.561e-30 1.00
SIK3_HUMAN SIK3 Serine/threonine-protein kinase SIK3 4.561e-30 1.00
PHKG1_HUMAN PHKG1 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 7.157e-30 1.00
TIE2_HUMAN TEK Angiopoietin-1 receptor 1.153e-29 1.00
EPHA5_HUMAN EPHA5 Ephrin type-A receptor 5 1.589e-29 1.00
VGFR3_HUMAN FLT4 Vascular endothelial growth factor receptor 3 2.568e-29 1.00
STK35_HUMAN STK35 Serine/threonine-protein kinase 35 5.504e-28 1.00
M3K19_HUMAN MAP3K19 Mitogen-activated protein kinase kinase kinase 19 5.403e-27 1.00
EPHB2_HUMAN EPHB2 Ephrin type-B receptor 2 7.255e-27 1.00
ULK3_HUMAN ULK3 Serine/threonine-protein kinase ULK3 1.804e-26 1.00
KS6A6_HUMAN RPS6KA6 Ribosomal protein S6 kinase alpha-6 6.023e-26 1.00
EPHA1_HUMAN EPHA1 Ephrin type-A receptor 1 1.056e-25 1.00
EPHB1_HUMAN EPHB1 Ephrin type-B receptor 1 1.056e-25 1.00
SIK2_HUMAN SIK2 Serine/threonine-protein kinase SIK2 1.07e-25 1.00
RIPK4_HUMAN RIPK4 Receptor-interacting serine/threonine-protein kinase 4 1.317e-25 1.00
RIPK2_HUMAN RIPK2 Receptor-interacting serine/threonine-protein kinase 2 6.265e-25 1.00
M3K4_HUMAN MAP3K4 Mitogen-activated protein kinase kinase kinase 4 9.723e-25 1.00
EPHA7_HUMAN EPHA7 Ephrin type-A receptor 7 5.495e-24 1.00
MRCKB_HUMAN CDC42BPB Serine/threonine-protein kinase MRCK beta 7.773e-24 1.00
AURKB_HUMAN AURKB Aurora kinase B 7.786e-24 1.00
EPHA3_HUMAN EPHA3 Ephrin type-A receptor 3 1.028e-23 1.00
CSK_HUMAN CSK Tyrosine-protein kinase CSK 2.01e-23 1.00
ABL2_HUMAN ABL2 Tyrosine-protein kinase ABL2 2.022e-23 1.00
GAK_HUMAN GAK Cyclin-G-associated kinase 7.314e-23 1.00
TIE1_HUMAN TIE1 Tyrosine-protein kinase receptor Tie-1 8.53e-23 1.00
MP2K1_HUMAN MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 9.013e-22 1.00
M4K3_HUMAN MAP4K3 Mitogen-activated protein kinase kinase kinase kinase 3 1.344e-21 1.00
TXK_HUMAN TXK Tyrosine-protein kinase TXK 2.127e-21 1.00
M4K1_HUMAN MAP4K1 Mitogen-activated protein kinase kinase kinase kinase 1 8.389e-21 1.00
MKNK2_HUMAN MKNK2 MAP kinase-interacting serine/threonine-protein kinase 2 8.53e-21 1.00
PGFRA_HUMAN PDGFRA Platelet-derived growth factor receptor alpha 2.47e-20 1.00
FGR_HUMAN FGR Tyrosine-protein kinase Fgr 5.187e-19 1.00
TESK1_HUMAN TESK1 Dual specificity testis-specific protein kinase 1 3.874e-18 1.00
SIK1_HUMAN SIK1 Serine/threonine-protein kinase SIK1 4.054e-18 1.00
CSF1R_HUMAN CSF1R Macrophage colony-stimulating factor 1 receptor 7.014e-18 1.00
STK33_HUMAN STK33 Serine/threonine-protein kinase 33 8.709e-18 1.00
MET_HUMAN MET Hepatocyte growth factor receptor 1.516e-17 1.00
EPHA4_HUMAN EPHA4 Ephrin type-A receptor 4 2.053e-17 1.00
TNI3K_HUMAN TNNI3K Serine/threonine-protein kinase TNNI3K 1.11e-16 1.00
FGFR1_HUMAN FGFR1 Fibroblast growth factor receptor 1 9.992e-16 1.00
FGFR2_HUMAN FGFR2 Fibroblast growth factor receptor 2 8.216e-15 1.00
KIT_HUMAN KIT Mast/stem cell growth factor receptor Kit 1.465e-14 1.00
ALK_HUMAN ALK ALK tyrosine kinase receptor 1.488e-14 1.00
TNIK_HUMAN TNIK TRAF2 and NCK-interacting protein kinase 3.031e-14 1.00
UFO_HUMAN AXL Tyrosine-protein kinase receptor UFO 7.55e-14 1.00
AURKC_HUMAN AURKC Aurora kinase C 1.357e-13 1.00
LTK_HUMAN LTK Leukocyte tyrosine kinase receptor 3.607e-13 1.00
MKNK1_HUMAN MKNK1 MAP kinase-interacting serine/threonine-protein kinase 1 4.559e-13 1.00
PHKG2_HUMAN PHKG2 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 1.312e-12 1.00
DDR1_HUMAN DDR1 Epithelial discoidin domain-containing receptor 1 3.973e-12 1.00
BMR1B_HUMAN BMPR1B Bone morphogenetic protein receptor type-1B 4.142e-12 1.00
FLT3_HUMAN FLT3 Receptor-type tyrosine-protein kinase FLT3 1.248e-11 1.00
SRMS_HUMAN SRMS Tyrosine-protein kinase Srms 5.018e-11 1.00
DDR2_HUMAN DDR2 Discoidin domain-containing receptor 2 1.513e-10 1.00
YES_HUMAN YES1 Tyrosine-protein kinase Yes 2.436e-10 1.00
LCK_HUMAN LCK Tyrosine-protein kinase Lck 3.221e-10 1.00
FRK_HUMAN FRK Tyrosine-protein kinase FRK 3.393e-10 1.00
MP2K2_HUMAN MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 4.397e-10 1.00
RON_HUMAN MST1R Macrophage-stimulating protein receptor 5.059e-10 1.00
FYN_HUMAN FYN Tyrosine-protein kinase Fyn 5.984e-10 1.00
SLK_HUMAN SLK STE20-like serine/threonine-protein kinase 6.38e-10 1.00
BLK_HUMAN BLK Tyrosine-protein kinase Blk 1.412e-09 1.00
MERTK_HUMAN MERTK Tyrosine-protein kinase Mer 3.113e-09 1.00
LRRK2_HUMAN LRRK2 Leucine-rich repeat serine/threonine-protein kinase 2 4.269e-09 1.00
IRAK1_HUMAN IRAK1 Interleukin-1 receptor-associated kinase 1 1.499e-08 1.00
KS6A1_HUMAN RPS6KA1 Ribosomal protein S6 kinase alpha-1 1.99e-08 1.00
KC1E_HUMAN CSNK1E Casein kinase I isoform epsilon 3.37e-08 1.00
MINK1_HUMAN MINK1 Misshapen-like kinase 1 1.297e-07 1.00
ACVR1_HUMAN ACVR1 Activin receptor type-1 1.71e-07 1.00
LYN_HUMAN LYN Tyrosine-protein kinase Lyn 1.721e-07 1.00
PTK6_HUMAN PTK6 Protein-tyrosine kinase 6 2.07e-07 1.00
HCK_HUMAN HCK Tyrosine-protein kinase HCK 2.278e-07 1.00
M4K5_HUMAN MAP4K5 Mitogen-activated protein kinase kinase kinase kinase 5 2.539e-07 1.00
ACVL1_HUMAN ACVRL1 Serine/threonine-protein kinase receptor R3 8.647e-07 1.00
TYRO3_HUMAN TYRO3 Tyrosine-protein kinase receptor TYRO3 1.889e-06 1.00
CDK7_HUMAN CDK7 Cyclin-dependent kinase 7 2.984e-06 1.00
MRCKA_HUMAN CDC42BPA Serine/threonine-protein kinase MRCK alpha 5.112e-06 1.00
M3K20_HUMAN MAP3K20 Mitogen-activated protein kinase kinase kinase 20 1.609e-05 1.00
PLK4_HUMAN PLK4 Serine/threonine-protein kinase PLK4 4.194e-05 1.00
ABL1_HUMAN ABL1 Tyrosine-protein kinase ABL1 0.0002058 1.00
M4K4_HUMAN MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4 0.0002776 1.00
MK14_HUMAN MAPK14 Mitogen-activated protein kinase 14 0.0003451 1.00
M4K2_HUMAN MAP4K2 Mitogen-activated protein kinase kinase kinase kinase 2 0.0005562 1.00
AAPK1_HUMAN PRKAA1 5'-AMP-activated protein kinase catalytic subunit alpha-1 0.0006764 1.00
IRAK4_HUMAN IRAK4 Interleukin-1 receptor-associated kinase 4 0.004894 1.00
FGFR4_HUMAN FGFR4 Fibroblast growth factor receptor 4 0.02065 1.00
FGFR3_HUMAN FGFR3 Fibroblast growth factor receptor 3 0.1191 1.00
KS6B1_HUMAN RPS6KB1 Ribosomal protein S6 kinase beta-1 0.122 1.00
BTK_HUMAN BTK Tyrosine-protein kinase BTK 0.1489 1.00
ROCK2_HUMAN ROCK2 Rho-associated protein kinase 2 0.1839 1.00
EHMT2_HUMAN EHMT2 Histone-lysine N-methyltransferase EHMT2 2.238e-173 0.41
EHMT1_HUMAN EHMT1 Histone-lysine N-methyltransferase EHMT1 8.836e-169 0.40
CCR4_MOUSE Ccr4 C-C chemokine receptor type 4 1.084e-86 0.38
DNM3A_HUMAN DNMT3A DNA (cytosine-5)-methyltransferase 3A 1.218e-69 0.41
KMT5A_HUMAN KMT5A N-lysine methyltransferase KMT5A 3.845e-62 0.34
F16P1_PIG FBP1 Fructose-1,6-bisphosphatase 1 1.017e-59 0.44
ERBB2_RAT Erbb2 Receptor tyrosine-protein kinase erbB-2 4.457e-59 0.38
PDE3B_HUMAN PDE3B cGMP-inhibited 3',5'-cyclic phosphodiesterase B 5.804e-56 0.39
PDE4B_RAT Pde4b cAMP-specific 3',5'-cyclic phosphodiesterase 4B 4.942e-47 0.34
DUS2L_HUMAN DUS2 tRNA-dihydrouridine(20) synthase [NAD(P)+]-like 5.023e-46 0.37
PDE3A_HUMAN PDE3A cGMP-inhibited 3',5'-cyclic phosphodiesterase A 1.642e-42 0.40
MK04_HUMAN MAPK4 Mitogen-activated protein kinase 4 2.456e-34 0.44
EGFR_MOUSE Egfr Epidermal growth factor receptor 1.75e-32 0.29
BRAF_HUMAN BRAF Serine/threonine-protein kinase B-raf 4.861e-32 0.42
ULK3_MOUSE Ulk3 Serine/threonine-protein kinase ULK3 1.464e-30 0.44
AURKA_HUMAN AURKA Aurora kinase A 1.976e-29 0.51
CCR4_HUMAN CCR4 C-C chemokine receptor type 4 6.147e-28 0.39
MK07_HUMAN MAPK7 Mitogen-activated protein kinase 7 1.359e-24 0.33
UR2R_MOUSE Uts2r Urotensin-2 receptor 1.736e-24 0.30
E2AK3_HUMAN EIF2AK3 Eukaryotic translation initiation factor 2-alpha kinase 3 5.224e-24 0.44
AUKBA_XENLA aurkb-a Aurora kinase B-A 2.07e-23 0.38
HD_HUMAN HTT Huntingtin 4.117e-22 0.36
SBK1_HUMAN SBK1 Serine/threonine-protein kinase SBK1 8.378e-22 0.44
DMPK_HUMAN DMPK Myotonin-protein kinase 9.016e-22 0.44
ENPP1_HUMAN ENPP1 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 1.767e-21 0.46
FAK1_HUMAN PTK2 Focal adhesion kinase 1 1.862e-21 0.40
RAF1_HUMAN RAF1 RAF proto-oncogene serine/threonine-protein kinase 1.607e-20 0.42
STK36_HUMAN STK36 Serine/threonine-protein kinase 36 6.972e-18 0.44
BLK_MOUSE Blk Tyrosine-protein kinase Blk 1.882e-17 0.33
PGFRB_RAT Pdgfrb Platelet-derived growth factor receptor beta 1.11e-16 0.42
SRC_RAT Src Proto-oncogene tyrosine-protein kinase Src 4.441e-16 0.32
MYO3A_HUMAN MYO3A Myosin-IIIa 6.661e-16 0.33
M3K3_HUMAN MAP3K3 Mitogen-activated protein kinase kinase kinase 3 7.772e-16 0.44
INSR_HUMAN INSR Insulin receptor 2.109e-15 0.44
VRK2_HUMAN VRK2 Serine/threonine-protein kinase VRK2 3.442e-15 0.33
MYO3B_HUMAN MYO3B Myosin-IIIb 4.108e-15 0.33
F16P1_HUMAN FBP1 Fructose-1,6-bisphosphatase 1 4.996e-15 0.46
WEE2_HUMAN WEE2 Wee1-like protein kinase 2 1.621e-14 0.33
M3K2_HUMAN MAP3K2 Mitogen-activated protein kinase kinase kinase 2 2.365e-14 0.44
5HT4R_CAVPO HTR4 5-hydroxytryptamine receptor 4 3.342e-14 0.32
CLK1_MOUSE Clk1 Dual specificity protein kinase CLK1 4.463e-14 0.43
NIM1_HUMAN NIM1K Serine/threonine-protein kinase NIM1 8.049e-14 0.33
NCOA1_HUMAN NCOA1 Nuclear receptor coactivator 1 1.872e-13 0.47
C3SLB7_ECOLX glmU Bifunctional protein GlmU 2.122e-13 0.36
PRKDC_HUMAN PRKDC DNA-dependent protein kinase catalytic subunit 1.52e-12 0.33
DRD1_BOVIN DRD1 D(1A) dopamine receptor 1.629e-12 0.31
KHK_HUMAN KHK Ketohexokinase 3.75e-12 0.32
PMYT1_HUMAN PKMYT1 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase 3.914e-12 0.33
MYLK2_HUMAN MYLK2 Myosin light chain kinase 2, skeletal/cardiac muscle 4.13e-12 0.44
BRDT_HUMAN BRDT Bromodomain testis-specific protein 4.723e-12 0.29
ATM_HUMAN ATM Serine-protein kinase ATM 4.963e-12 0.32
ABCG2_HUMAN ABCG2 Broad substrate specificity ATP-binding cassette transporter ABCG2 7.852e-12 0.44
DCLK3_HUMAN DCLK3 Serine/threonine-protein kinase DCLK3 7.899e-12 0.44
IRAK3_HUMAN IRAK3 Interleukin-1 receptor-associated kinase 3 1.992e-11 0.44
NEK11_HUMAN NEK11 Serine/threonine-protein kinase Nek11 2.335e-11 0.33
KS6A4_HUMAN RPS6KA4 Ribosomal protein S6 kinase alpha-4 5.683e-11 0.44
NEK3_HUMAN NEK3 Serine/threonine-protein kinase Nek3 8.739e-11 0.29
SRPK3_HUMAN SRPK3 SRSF protein kinase 3 9.732e-11 0.33
AAK1_HUMAN AAK1 AP2-associated protein kinase 1 9.798e-11 0.33
GRK4_HUMAN GRK4 G protein-coupled receptor kinase 4 1.761e-10 0.33
NUAK2_HUMAN NUAK2 NUAK family SNF1-like kinase 2 1.932e-10 0.44
RIOK1_HUMAN RIOK1 Serine/threonine-protein kinase RIO1 2.533e-10 0.33
RIOK3_HUMAN RIOK3 Serine/threonine-protein kinase RIO3 2.533e-10 0.33
NLK_HUMAN NLK Serine/threonine-protein kinase NLK 3.004e-10 0.44
STK4_HUMAN STK4 Serine/threonine-protein kinase 4 5.193e-10 0.33
DYR1A_HUMAN DYRK1A Dual specificity tyrosine-phosphorylation-regulated kinase 1A 1.158e-09 0.43
BMP2K_HUMAN BMP2K BMP-2-inducible protein kinase 2.115e-09 0.33
TAOK2_HUMAN TAOK2 Serine/threonine-protein kinase TAO2 2.115e-09 0.33
TLK2_HUMAN TLK2 Serine/threonine-protein kinase tousled-like 2 2.37e-09 0.33
F16P1_RAT Fbp1 Fructose-1,6-bisphosphatase 1 2.738e-09 0.32
PI42C_HUMAN PIP4K2C Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma 3.414e-09 0.44
GRK7_HUMAN GRK7 Rhodopsin kinase GRK7 3.47e-09 0.33
STK26_HUMAN STK26 Serine/threonine-protein kinase 26 7.006e-09 0.33
CSKP_HUMAN CASK Peripheral plasma membrane protein CASK 7.167e-09 0.33
MAST1_HUMAN MAST1 Microtubule-associated serine/threonine-protein kinase 1 7.167e-09 0.33
STK39_HUMAN STK39 STE20/SPS1-related proline-alanine-rich protein kinase 7.167e-09 0.33
GP119_HUMAN GPR119 Glucose-dependent insulinotropic receptor 1.461e-08 0.38
PDE4D_HUMAN PDE4D cAMP-specific 3',5'-cyclic phosphodiesterase 4D 1.74e-08 0.34
KC1AL_HUMAN CSNK1A1L Casein kinase I isoform alpha-like 1.881e-08 0.33
DYR1B_HUMAN DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B 2.05e-08 0.42
HIPK3_HUMAN HIPK3 Homeodomain-interacting protein kinase 3 2.485e-08 0.33
E2AK1_HUMAN EIF2AK1 Eukaryotic translation initiation factor 2-alpha kinase 1 2.709e-08 0.33
CDK16_HUMAN CDK16 Cyclin-dependent kinase 16 3.057e-08 0.33
VP16_HHV11 Tegument protein VP16 3.229e-08 0.33
CLK3_HUMAN CLK3 Dual specificity protein kinase CLK3 3.775e-08 0.33
TLK1_HUMAN TLK1 Serine/threonine-protein kinase tousled-like 1 4.403e-08 0.33
PLK1_HUMAN PLK1 Serine/threonine-protein kinase PLK1 4.482e-08 0.33
LUCI_RENRE Coelenterazine h 2-monooxygenase 4.951e-08 0.28
M3K1_HUMAN MAP3K1 Mitogen-activated protein kinase kinase kinase 1 9.381e-08 0.33
PDE10_HUMAN PDE10A cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 1.078e-07 0.40
HIPK1_HUMAN HIPK1 Homeodomain-interacting protein kinase 1 1.529e-07 0.33
CDK15_HUMAN CDK15 Cyclin-dependent kinase 15 1.848e-07 0.33
PDE4A_HUMAN PDE4A cAMP-specific 3',5'-cyclic phosphodiesterase 4A 1.876e-07 0.34
CLK1_HUMAN CLK1 Dual specificity protein kinase CLK1 2.479e-07 0.44
STK24_HUMAN STK24 Serine/threonine-protein kinase 24 3.409e-07 0.33
ADA1B_RAT Adra1b Alpha-1B adrenergic receptor 4.098e-07 0.30
NEK7_HUMAN NEK7 Serine/threonine-protein kinase Nek7 4.225e-07 0.29
E2AK4_HUMAN EIF2AK4 eIF-2-alpha kinase GCN2 6.334e-07 0.33
TTK_HUMAN TTK Dual specificity protein kinase TTK 6.453e-07 0.33
PDE1B_HUMAN PDE1B Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B 7.452e-07 0.35
IGF1R_HUMAN IGF1R Insulin-like growth factor 1 receptor 7.918e-07 0.42
ACH10_RAT Chrna10 Neuronal acetylcholine receptor subunit alpha-10 1.044e-06 0.30
HIPK4_HUMAN HIPK4 Homeodomain-interacting protein kinase 4 1.432e-06 0.44
CDK14_HUMAN CDK14 Cyclin-dependent kinase 14 1.574e-06 0.33
DUSTY_HUMAN DSTYK Dual serine/threonine and tyrosine protein kinase 1.574e-06 0.33
MP2K6_HUMAN MAP2K6 Dual specificity mitogen-activated protein kinase kinase 6 1.574e-06 0.33
NCOA3_HUMAN NCOA3 Nuclear receptor coactivator 3 1.744e-06 0.47
ADA1D_RAT Adra1d Alpha-1D adrenergic receptor 2.009e-06 0.30
ADA1A_RAT Adra1a Alpha-1A adrenergic receptor 2.155e-06 0.30
BRAF_MOUSE Braf Serine/threonine-protein kinase B-raf 2.417e-06 0.33
M3K13_HUMAN MAP3K13 Mitogen-activated protein kinase kinase kinase 13 2.417e-06 0.33
UR2R_HUMAN UTS2R Urotensin-2 receptor 2.703e-06 0.31
KKCC2_HUMAN CAMKK2 Calcium/calmodulin-dependent protein kinase kinase 2 2.792e-06 0.33
ADA1B_HUMAN ADRA1B Alpha-1B adrenergic receptor 3.023e-06 0.32
ANKK1_HUMAN ANKK1 Ankyrin repeat and protein kinase domain-containing protein 1 3.596e-06 0.33
PI51A_HUMAN PIP5K1A Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha 3.596e-06 0.33
TAOK3_HUMAN TAOK3 Serine/threonine-protein kinase TAO3 4.375e-06 0.33
STK25_HUMAN STK25 Serine/threonine-protein kinase 25 5.201e-06 0.33
SGMR1_MOUSE Sigmar1 Sigma non-opioid intracellular receptor 1 5.495e-06 0.31
CDK9_HUMAN CDK9 Cyclin-dependent kinase 9 7.084e-06 0.43
ST17B_HUMAN STK17B Serine/threonine-protein kinase 17B 7.282e-06 0.44

Mavorixafor

CXCR4_HUMAN CXCR4 C-X-C chemokine receptor type 4 2.969e-279 1.00
CXCR4_MOUSE Cxcr4 C-X-C chemokine receptor type 4 1.237e-71 0.37
KCNN3_RAT Kcnn3 Small conductance calcium-activated potassium channel protein 3 1.861e-45 0.38
CXCR4_MACMU CXCR4 C-X-C chemokine receptor type 4 1.52e-40 0.32
CACB3_RAT Cacnb3 Voltage-dependent L-type calcium channel subunit beta-3 1.678e-36 0.29
CAC1C_HUMAN CACNA1C Voltage-dependent L-type calcium channel subunit alpha-1C 2.87e-19 0.35
ENV_HV1H2 env Envelope glycoprotein gp160 1.132e-14 0.32
CAC1H_HUMAN CACNA1H Voltage-dependent T-type calcium channel subunit alpha-1H 1.454e-14 0.38
KCNN3_HUMAN KCNN3 Small conductance calcium-activated potassium channel protein 3 2.007e-12 0.38
KCNN1_HUMAN KCNN1 Small conductance calcium-activated potassium channel protein 1 4.95e-10 0.32
PDE10_HUMAN PDE10A cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 1.879e-08 0.35
KCNN2_HUMAN KCNN2 Small conductance calcium-activated potassium channel protein 2 1.993e-08 0.32
SCN4A_RAT Scn4a Sodium channel protein type 4 subunit alpha 8.741e-08 0.29
UPAR_HUMAN PLAUR Urokinase plasminogen activator surface receptor 2.38e-07 0.30
PRIO_MESAU PRNP Major prion protein 1.507e-06 0.30
TYTR_TRYCR TPR Trypanothione reductase 4.389e-06 0.36

Levoketoconazole

CP21A_HUMAN CYP21A2 Steroid 21-hydroxylase 5.862e-248 1.00
CP11A_RAT Cyp11a1 Cholesterol side-chain cleavage enzyme, mitochondrial 2.335e-181 1.00
CP7A1_RAT Cyp7a1 Cytochrome P450 7A1 2.335e-181 1.00
CP3A5_HUMAN CYP3A5 Cytochrome P450 3A5 2.9e-124 1.00
CP51A_RAT Cyp51a1 Lanosterol 14-alpha demethylase 8.86e-120 1.00
C11B1_BOVIN CYP11B1 Cytochrome P450 11B1, mitochondrial 8.54e-64 1.00
CP51A_HUMAN CYP51A1 Lanosterol 14-alpha demethylase 1.466e-51 1.00
CP27B_HUMAN CYP27B1 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial 3.937e-30 1.00
CP17A_HUMAN CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase 1.599e-23 1.00
CP27B_MOUSE Cyp27b1 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial 2.176e-19 1.00
C11B1_HUMAN CYP11B1 Cytochrome P450 11B1, mitochondrial 2.026e-18 1.00
MDR1A_MOUSE Abcb1a ATP-dependent translocase ABCB1 9.992e-16 1.00
MDR1B_MOUSE Abcb1b ATP-dependent translocase ABCB1 8.327e-15 1.00
S22A1_HUMAN SLC22A1 Solute carrier family 22 member 1 4.785e-14 1.00
THAS_HUMAN TBXAS1 Thromboxane-A synthase 3.771e-13 1.00
CP24A_HUMAN CYP24A1 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial 4.222e-09 1.00
LOX15_RABIT ALOX15 Arachidonate 15-lipoxygenase 1.934e-08 1.00
Q8IL32_PLAF7 Heat shock protein 90, putative 9.221e-07 1.00
CAC1C_RAT Cacna1c Voltage-dependent L-type calcium channel subunit alpha-1C 1.851e-06 1.00
ADA2B_HUMAN ADRA2B Alpha-2B adrenergic receptor 7.282e-06 1.00
GNRHR_RAT Gnrhr Gonadotropin-releasing hormone receptor 0.0001102 1.00
CP19A_HUMAN CYP19A1 Aromatase 0.0001338 1.00
ADA2A_HUMAN ADRA2A Alpha-2A adrenergic receptor 0.0003946 1.00
HS90A_HUMAN HSP90AA1 Heat shock protein HSP 90-alpha 0.0009778 1.00
5HT1B_RAT Htr1b 5-hydroxytryptamine receptor 1B 0.001409 1.00
NK2R_HUMAN TACR2 Substance-K receptor 0.005765 1.00
C11B2_HUMAN CYP11B2 Cytochrome P450 11B2, mitochondrial 0.0206 1.00
CP3A4_HUMAN CYP3A4 Cytochrome P450 3A4 0.04806 1.00
MDR1_HUMAN ABCB1 ATP-dependent translocase ABCB1 0.05954 1.00
ACM2_HUMAN CHRM2 Muscarinic acetylcholine receptor M2 0.09618 1.00
SC6A4_HUMAN SLC6A4 Sodium-dependent serotonin transporter 0.6236 1.00
KCNH2_HUMAN KCNH2 Potassium voltage-gated channel subfamily H member 2 0.7193 1.00
OPRD_HUMAN OPRD1 Delta-type opioid receptor 0.8309 1.00
HMOX1_RAT Hmox1 Heme oxygenase 1 5.899e-120 0.50
CP51A_ASPFU cyp51A 14-alpha sterol demethylase Cyp51A 5.265e-54 0.56
Q96W81_ASPFM cyp51B 14-alpha sterol demethylase 7.03e-45 0.56
HMOX2_RAT Hmox2 Heme oxygenase 2 3.025e-43 0.50
CP51_CANAL ERG11 Lanosterol 14-alpha demethylase 9.916e-38 0.32
HMOX1_HUMAN HMOX1 Heme oxygenase 1 1.476e-29 0.37
CP121_MYCTU cyp121 Mycocyclosin synthase 3.317e-24 0.30
A2TEF2_LEIIN CYP51 Putative lanosterol 14-alpha-demethylase 1.673e-23 0.29
CP74A_ARATH CYP74A Allene oxide synthase, chloroplastic 1.104e-19 0.30
I23O2_MOUSE Ido2 Indoleamine 2,3-dioxygenase 2 1.11e-15 0.30
ALK_HUMAN ALK ALK tyrosine kinase receptor 7.216e-15 0.36
TRPM2_HUMAN TRPM2 Transient receptor potential cation channel subfamily M member 2 3.4e-12 0.30
CP51_MYCTU cyp51 Lanosterol 14-alpha demethylase 1.609e-09 0.30
XCT_HUMAN SLC7A11 Cystine/glutamate transporter 6.591e-08 0.31
5HT3A_CAVPO HTR3A 5-hydroxytryptamine receptor 3A 2.78e-07 0.32
FA10_HUMAN F10 Coagulation factor X 2.933e-07 0.35
IGF1R_HUMAN IGF1R Insulin-like growth factor 1 receptor 4.259e-07 0.34
Q6UCJ9_TOXGO ENR Enoyl-acyl carrier reductase 2.042e-06 0.39
CCR1_HUMAN CCR1 C-C chemokine receptor type 1 4.993e-06 0.30
THAS_RAT Tbxas1 Thromboxane-A synthase 7.971e-06 0.32

Rimonabant

CNR1_RAT Cnr1 Cannabinoid receptor 1 4.926e-233 1.00
CNR1_HUMAN CNR1 Cannabinoid receptor 1 1.461e-165 1.00
CNR2_HUMAN CNR2 Cannabinoid receptor 2 1.848e-90 1.00
CNR1_MOUSE Cnr1 Cannabinoid receptor 1 1.638e-132 0.66
CNR2_MOUSE Cnr2 Cannabinoid receptor 2 2.091e-101 0.91
PRP19_YEAST PRP19 Pre-mRNA-processing factor 19 3.892e-41 0.57
PPARD_CANLF PPARD Peroxisome proliferator-activated receptor delta 1.007e-35 0.28
SYMC_HUMAN MARS1 Methionine--tRNA ligase, cytoplasmic 4.363e-27 0.39
GBRB2_HUMAN GABRB2 Gamma-aminobutyric acid receptor subunit beta-2 1.569e-25 0.41
SCNAA_MOUSE Scn10a Sodium channel protein type 10 subunit alpha 7.904e-24 0.35
ENL_HUMAN MLLT1 Protein ENL 1.444e-23 0.29
WDR5_HUMAN WDR5 WD repeat-containing protein 5 3.077e-18 0.32
LIPL_BOVIN LPL Lipoprotein lipase 6.229e-18 0.28
NLRP3_MOUSE Nlrp3 NACHT, LRR and PYD domains-containing protein 3 2.29e-17 0.33
TRPC6_HUMAN TRPC6 Short transient receptor potential channel 6 6.55e-15 0.30
RFA1_HUMAN RPA1 Replication protein A 70 kDa DNA-binding subunit 8.882e-15 0.44
TSPO_RAT Tspo Translocator protein 4.141e-14 0.42
LIPS_RAT Lipe Hormone-sensitive lipase 7.404e-13 0.35
GBRA2_HUMAN GABRA2 Gamma-aminobutyric acid receptor subunit alpha-2 3.896e-12 0.41
LIPS_HUMAN LIPE Hormone-sensitive lipase 2.025e-11 0.38
CA2D2_HUMAN CACNA2D2 Voltage-dependent calcium channel subunit alpha-2/delta-2 1.551e-10 0.37
MEP2_YEAST MEP2 Ammonium transporter MEP2 5.575e-10 0.29
SCN2A_HUMAN SCN2A Sodium channel protein type 2 subunit alpha 5.999e-10 0.34
GBRG2_HUMAN GABRG2 Gamma-aminobutyric acid receptor subunit gamma-2 1.11e-09 0.41
ENPP3_HUMAN ENPP3 Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 1.91e-09 0.30
TRPC3_HUMAN TRPC3 Short transient receptor potential channel 3 2.154e-09 0.30
DRD1_HUMAN DRD1 D(1A) dopamine receptor 2.437e-09 0.32
GRM5_HUMAN GRM5 Metabotropic glutamate receptor 5 8.858e-09 0.39
LIPL_RAT Lpl Lipoprotein lipase 1.212e-08 0.32
NR1H4_HUMAN NR1H4 Bile acid receptor 2.458e-07 0.33
FABP5_HUMAN FABP5 Fatty acid-binding protein 5 2.695e-07 0.30
PYRD_HUMAN DHODH Dihydroorotate dehydrogenase (quinone), mitochondrial 3.325e-07 0.32
GRM4_HUMAN GRM4 Metabotropic glutamate receptor 4 3.685e-07 0.34
V2R_HUMAN AVPR2 Vasopressin V2 receptor 5.039e-07 0.33
SCNAA_HUMAN SCN10A Sodium channel protein type 10 subunit alpha 7.073e-07 0.34
OPRX_HUMAN OPRL1 Nociceptin receptor 8.543e-07 0.58
Q8I2J3_PLAF7 M18 aspartyl aminopeptidase 9.571e-07 0.31
FABPH_HUMAN FABP3 Fatty acid-binding protein, heart 1.552e-06 0.30
GRM1_HUMAN GRM1 Metabotropic glutamate receptor 1 2.138e-06 0.34
CXCR3_HUMAN CXCR3 C-X-C chemokine receptor type 3 5.022e-06 0.32
AGP1_YEAST AGP1 General amino acid permease AGP1 5.99e-06 0.29
PP1A_HUMAN PPP1CA Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 6.871e-06 0.33

Cariprazine

DRD3_HUMAN DRD3 D(3) dopamine receptor 3.451e-224 1.00
DRD2_HUMAN DRD2 D(2) dopamine receptor 1.518e-194 1.00
5HT2A_HUMAN HTR2A 5-hydroxytryptamine receptor 2A 5.748e-184 1.00
DRD3_RAT Drd3 D(3) dopamine receptor 7.471e-98 1.00
5HT1A_HUMAN HTR1A 5-hydroxytryptamine receptor 1A 1.358e-76 1.00
DRD4_HUMAN DRD4 D(4) dopamine receptor 9.504e-66 1.00
DRD2_RAT Drd2 D(2) dopamine receptor 2.071e-47 1.00
DRD1_HUMAN DRD1 D(1A) dopamine receptor 1.362e-27 1.00
DRD5_HUMAN DRD5 D(1B) dopamine receptor 2.051e-10 1.00
ADA1A_RABIT ADRA1A Alpha-1A adrenergic receptor 1.134e-80 0.37
5HT1A_RAT Htr1a 5-hydroxytryptamine receptor 1A 4.219e-77 0.62
G3I1B6_CRIGR 5-hydroxytryptamine receptor 1.768e-64 0.37
5HT1B_CRIGR HTR1B 5-hydroxytryptamine receptor 1B 1.059e-63 0.37
DRD1_PIG DRD1 D(1A) dopamine receptor 4.511e-49 0.45
5HT2C_HUMAN HTR2C 5-hydroxytryptamine receptor 2C 2.786e-46 0.45
5HT7R_RAT Htr7 5-hydroxytryptamine receptor 7 8.224e-46 0.38
5HT7R_CAVPO HTR7 5-hydroxytryptamine receptor 7 9.948e-44 0.34
5HT7R_HUMAN HTR7 5-hydroxytryptamine receptor 7 3.049e-43 0.50
ACKR3_HUMAN ACKR3 Atypical chemokine receptor 3 1.366e-41 0.34
CRFR2_HUMAN CRHR2 Corticotropin-releasing factor receptor 2 3.696e-40 0.30
DCNL1_HUMAN DCUN1D1 DCN1-like protein 1 3.268e-39 0.31
ADA1D_RAT Adra1d Alpha-1D adrenergic receptor 8.631e-38 0.41
ENV_HV1Y2 env Envelope glycoprotein gp160 2.053e-36 0.35
AATC_HUMAN GOT1 Aspartate aminotransferase, cytoplasmic 2.222e-36 0.29
5HT2A_RAT Htr2a 5-hydroxytryptamine receptor 2A 5.915e-36 0.41
SC6A4_HUMAN SLC6A4 Sodium-dependent serotonin transporter 7.69e-32 0.47
NPY2R_HUMAN NPY2R Neuropeptide Y receptor type 2 9.308e-28 0.36
EHMT2_MOUSE Ehmt2 Histone-lysine N-methyltransferase EHMT2 6.474e-25 0.31
GHSR_MOUSE Ghsr Growth hormone secretagogue receptor type 1 3.817e-23 0.28
MYT1_HUMAN MYT1 Myelin transcription factor 1 6.794e-23 0.28
ADA1A_HUMAN ADRA1A Alpha-1A adrenergic receptor 1.986e-22 0.43
5HT1B_HUMAN HTR1B 5-hydroxytryptamine receptor 1B 3.052e-22 0.37
PTGES_HUMAN PTGES Prostaglandin E synthase 4.655e-22 0.35
5HT1D_HUMAN HTR1D 5-hydroxytryptamine receptor 1D 5.394e-21 0.37
ADA1B_HUMAN ADRA1B Alpha-1B adrenergic receptor 3.226e-20 0.40
H10_HUMAN H1-0 Histone H1.0 3.352e-19 0.37
O70424_RAT Neuropeptide Y-Y2 receptor 4.879e-18 0.29
PSBA_MARPO psbA Photosystem II protein D1 6.643e-18 0.30
Q1HEC0_RAT Acetyl-Coenzyme A carboxylase 2 9.507e-18 0.28
AP2S1_RAT Ap2s1 AP-2 complex subunit sigma 1.517e-17 0.32
5HT1B_RAT Htr1b 5-hydroxytryptamine receptor 1B 2.821e-17 0.37
NPY5R_HUMAN NPY5R Neuropeptide Y receptor type 5 3.375e-17 0.35
5HT4R_HUMAN HTR4 5-hydroxytryptamine receptor 4 1.11e-16 0.34
ADA1A_RAT Adra1a Alpha-1A adrenergic receptor 1.11e-16 0.44
KCNQ2_HUMAN KCNQ2 Potassium voltage-gated channel subfamily KQT member 2 2.22e-16 0.32
FAAH1_HUMAN FAAH Fatty-acid amide hydrolase 1 6.661e-16 0.45
ADA2A_RAT Adra2a Alpha-2A adrenergic receptor 1.776e-15 0.29
ADA1D_HUMAN ADRA1D Alpha-1D adrenergic receptor 4.996e-15 0.37
Q9SPL6_CICIN PPX1 Protoporphyrinogen oxidase 5.884e-15 0.28
Q9XQA6_POAAN psbA Photosystem II protein D1 5.884e-15 0.28
CAC1G_HUMAN CACNA1G Voltage-dependent T-type calcium channel subunit alpha-1G 7.216e-15 0.39
BLK_MOUSE Blk Tyrosine-protein kinase Blk 7.772e-15 0.28
SAHH_HUMAN AHCY Adenosylhomocysteinase 1.277e-14 0.30
ACM5_RAT Chrm5 Muscarinic acetylcholine receptor M5 2.032e-14 0.39
ADA1A_BOVIN ADRA1A Alpha-1A adrenergic receptor 7.139e-14 0.36
5HT1D_MOUSE Htr1d 5-hydroxytryptamine receptor 1D 1.014e-13 0.34
CRFR1_HUMAN CRHR1 Corticotropin-releasing factor receptor 1 3.361e-13 0.32
VRK2_HUMAN VRK2 Serine/threonine-protein kinase VRK2 6.325e-13 0.28
MELK_HUMAN MELK Maternal embryonic leucine zipper kinase 1.652e-12 0.31
S6A12_HUMAN SLC6A12 Sodium- and chloride-dependent betaine transporter 3.999e-12 0.30
ACES_MOUSE Ache Acetylcholinesterase 4.705e-12 0.31
5HT6R_HUMAN HTR6 5-hydroxytryptamine receptor 6 6.018e-12 0.50
CALM_BOVIN CALM Calmodulin 6.023e-11 0.29
SGMR1_HUMAN SIGMAR1 Sigma non-opioid intracellular receptor 1 9.118e-11 0.41
SC6A4_RAT Slc6a4 Sodium-dependent serotonin transporter 1.541e-10 0.42
DRD4_RAT Drd4 D(4) dopamine receptor 2.362e-10 0.44
ACM4_RAT Chrm4 Muscarinic acetylcholine receptor M4 4.569e-10 0.39
MTR1B_HUMAN MTNR1B Melatonin receptor type 1B 5.499e-10 0.31
KCNH2_HUMAN KCNH2 Potassium voltage-gated channel subfamily H member 2 6.164e-10 0.45
NEK11_HUMAN NEK11 Serine/threonine-protein kinase Nek11 1.072e-09 0.28
Q9JN24_ECOLX def Peptide deformylase 2.293e-09 0.30
ACM1_HUMAN CHRM1 Muscarinic acetylcholine receptor M1 3.092e-09 0.35
ANM6_HUMAN PRMT6 Protein arginine N-methyltransferase 6 3.746e-09 0.32
MCHR1_HUMAN MCHR1 Melanin-concentrating hormone receptor 1 8.828e-09 0.41
MTR1A_HUMAN MTNR1A Melatonin receptor type 1A 1.026e-08 0.31
5HT2C_RAT Htr2c 5-hydroxytryptamine receptor 2C 1.373e-08 0.37
AVR2A_HUMAN ACVR2A Activin receptor type-2A 1.791e-08 0.28
TBA1A_RAT Tuba1a Tubulin alpha-1A chain 1.791e-08 0.28
Q6TUJ4_PSEAI blaIMP-1 Metallo beta-lactamase 7.127e-08 0.29
DRD2_BOVIN DRD2 D(2) dopamine receptor 9.009e-08 0.29
UBP47_HUMAN USP47 Ubiquitin carboxyl-terminal hydrolase 47 9.328e-08 0.29
CARM1_HUMAN CARM1 Histone-arginine methyltransferase CARM1 1.18e-07 0.32
COQ8A_HUMAN COQ8A Atypical kinase COQ8A, mitochondrial 1.35e-07 0.28
5HT1A_MOUSE Htr1a 5-hydroxytryptamine receptor 1A 2.617e-07 0.28
MRCKB_HUMAN CDC42BPB Serine/threonine-protein kinase MRCK beta 3.05e-07 0.28
MRCKG_HUMAN CDC42BPG Serine/threonine-protein kinase MRCK gamma 3.05e-07 0.28
DRD1_RAT Drd1 D(1A) dopamine receptor 3.054e-07 0.41
OPRX_HUMAN OPRL1 Nociceptin receptor 4.905e-07 0.36
SIK3_HUMAN SIK3 Serine/threonine-protein kinase SIK3 6.259e-07 0.28
P2RX7_HUMAN P2RX7 P2X purinoceptor 7 6.514e-07 0.39
TAF1_HUMAN TAF1 Transcription initiation factor TFIID subunit 1 7.896e-07 0.31
5HT4R_RAT Htr4 5-hydroxytryptamine receptor 4 8.263e-07 0.30
5HT5A_HUMAN HTR5A 5-hydroxytryptamine receptor 5A 8.389e-07 0.37
UR2R_RAT Uts2r Urotensin-2 receptor 9.492e-07 0.31
5HT2B_HUMAN HTR2B 5-hydroxytryptamine receptor 2B 1.063e-06 0.37
WEE2_HUMAN WEE2 Wee1-like protein kinase 2 1.186e-06 0.28
HYES_MOUSE Ephx2 Bifunctional epoxide hydrolase 2 1.228e-06 0.32
5HT4R_CAVPO HTR4 5-hydroxytryptamine receptor 4 1.367e-06 0.32
PSBA_SPIOL psbA Photosystem II protein D1 1.556e-06 0.30
BKRB1_HUMAN BDKRB1 B1 bradykinin receptor 1.619e-06 0.39
MK10_HUMAN MAPK10 Mitogen-activated protein kinase 10 1.889e-06 0.32
HRH1_CAVPO HRH1 Histamine H1 receptor 2.284e-06 0.37
SSR1_RAT Sstr1 Somatostatin receptor type 1 2.605e-06 0.37
SGMR1_RAT Sigmar1 Sigma non-opioid intracellular receptor 1 3.118e-06 0.44
AVR2B_HUMAN ACVR2B Activin receptor type-2B 3.531e-06 0.28
SBK1_HUMAN SBK1 Serine/threonine-protein kinase SBK1 3.531e-06 0.28
MK08_HUMAN MAPK8 Mitogen-activated protein kinase 8 3.935e-06 0.32
SGMR1_MOUSE Sigmar1 Sigma non-opioid intracellular receptor 1 3.977e-06 0.32
ACM1_RAT Chrm1 Muscarinic acetylcholine receptor M1 8.319e-06 0.39
M3K4_HUMAN MAP3K4 Mitogen-activated protein kinase kinase kinase 4 8.684e-06 0.28

Nalmefene

OPRK_CAVPO OPRK1 Kappa-type opioid receptor 3.381e-214 1.00
OPRD_HUMAN OPRD1 Delta-type opioid receptor 4.751e-199 1.00
OPRK_HUMAN OPRK1 Kappa-type opioid receptor 4.073e-180 1.00
OPRM_HUMAN OPRM1 Mu-type opioid receptor 4.735e-153 1.00
OPRD_RAT Oprd1 Delta-type opioid receptor 7.885e-134 1.00
OPRM_RAT Oprm1 Mu-type opioid receptor 2.988e-120 1.00
OPRM_MOUSE Oprm1 Mu-type opioid receptor 1.622e-182 0.79
OPRK_MOUSE Oprk1 Kappa-type opioid receptor 9.237e-159 0.79
OPRM_CAVPO OPRM1 Mu-type opioid receptor 4.29e-156 0.79
OPRD_MOUSE Oprd1 Delta-type opioid receptor 3.099e-133 0.79
OPRM_BOVIN OPRM1 Mu-type opioid receptor 2.714e-124 0.62
OPRK_RAT Oprk1 Kappa-type opioid receptor 3.155e-78 0.79
TLR4_MOUSE Tlr4 Toll-like receptor 4 2.715e-58 0.57
A0A286XTF2_CAVPO OPRD1 G_PROTEIN_RECEP_F1_2 domain-containing protein 4.63e-41 0.33
OPRX_HUMAN OPRL1 Nociceptin receptor 1.811e-23 0.62
OPRX_CAVPO OPRL1 Nociceptin receptor 1.522e-21 0.51
OGRL1_HUMAN OGFRL1 Opioid growth factor receptor-like protein 1 2.22e-16 0.41

Telaprevir

A3EZI9_9HEPC NS3 Genome polyprotein 4.025e-167 1.00
C1KIQ2_9HEPC NS3 protease 1.089e-50 1.00
Q91RS4_9HEPC NS3 protease 5.439e-42 1.00
CATB_HUMAN CTSB Cathepsin B 1.366e-23 1.00
CELA1_HUMAN CELA1 Chymotrypsin-like elastase family member 1 6.843e-21 1.00
A0A0K1CY61_9HEPC Nonstructural protein NS3-4A 2.442e-15 1.00
CATL1_HUMAN CTSL Cathepsin L1 1.511e-12 1.00
Q0ZMF1_9HEPC NS3 NS3 protease 1.514e-11 1.00
CATK_HUMAN CTSK Cathepsin K 5.586e-11 1.00
CATS_HUMAN CTSS Cathepsin S 3.967e-08 1.00
CATL2_HUMAN CTSV Cathepsin L2 1.942e-07 1.00
PLMN_HUMAN PLG Plasminogen 0.0002547 1.00
CMA1_HUMAN CMA1 Chymase 0.00206 1.00
ELNE_HUMAN ELANE Neutrophil elastase 0.09221 1.00
THRB_HUMAN F2 Prothrombin 0.4954 1.00
D2K2A8_9HEPC NS4A Non-structural protein 4A 3.96e-125 0.76
Q4U254_9ENTO protease Protease 1.115e-54 0.83
POLG_HCV77 Genome polyprotein 3.548e-49 0.45
PEPT1_DERPT DERP1 Peptidase 1 2.368e-31 0.42
Q9ERT1_MOUSE TRH-R2 Thyrotropin-releasing hormone receptor 2 1.823e-29 0.34
TRFR_MOUSE Trhr Thyrotropin-releasing hormone receptor 1.251e-20 0.34
POLG_HCV1 Genome polyprotein 2.326e-18 0.77
CTRA_BOVIN Chymotrypsinogen A 1.318e-12 0.73
P88142_9HIV2 pol Pol polyprotein 9.575e-10 0.28
PSB5_HUMAN PSMB5 Proteasome subunit beta type-5 3.266e-08 0.31

Sitaxentan

EDNRA_HUMAN EDNRA Endothelin-1 receptor 3.613e-165 1.00
EDNRB_HUMAN EDNRB Endothelin receptor type B 3.382e-64 1.00
EDNRA_RAT Ednra Endothelin-1 receptor 5.383e-55 1.00
EDNRB_RAT Ednrb Endothelin receptor type B 2.237e-29 0.32
PTPRG_HUMAN PTPRG Receptor-type tyrosine-protein phosphatase gamma 3.629e-12 0.30
AGTR1_HUMAN AGTR1 Type-1 angiotensin II receptor 7.935e-08 0.29

Regadenoson

AA2AR_RAT Adora2a Adenosine receptor A2a 2.325e-163 1.00
AA3R_HUMAN ADORA3 Adenosine receptor A3 1.774e-151 1.00
AA1R_HUMAN ADORA1 Adenosine receptor A1 7.104e-116 1.00
AA2AR_HUMAN ADORA2A Adenosine receptor A2a 1.038e-93 1.00
AA2BR_HUMAN ADORA2B Adenosine receptor A2b 1.305e-44 1.00
AA1R_RAT Adora1 Adenosine receptor A1 4.714e-237 0.58
MBTA_MYCTU mbtA Salicyl-AMP ligase / salicyl-S-ArCP synthetase 1.714e-179 0.47
OXGR1_RAT Oxgr1 2-oxoglutarate receptor 1 1.788e-166 0.44
S29A1_HUMAN SLC29A1 Equilibrative nucleoside transporter 1 2.602e-157 0.45
AA3R_RAT Adora3 Adenosine receptor A3 5.75e-138 0.58
ADK_TOXGO AK Adenosine kinase 1.943e-133 0.51
C3SIU2_ECOLX metJ Met repressor 2.59e-128 0.41
ADOK_MYCTO adoK Adenosine kinase 7.913e-121 0.35
AA1R_CHICK ADORA1 Adenosine receptor A1 1.969e-118 0.42
DNPH1_HUMAN DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 5.441e-116 0.37
DNPH1_RAT Dnph1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 1.9e-114 0.37
S28A2_HUMAN SLC28A2 Sodium/nucleoside cotransporter 2 2.081e-112 0.35
AA1R_RABIT ADORA1 Adenosine receptor A1 9.553e-109 0.35
AA3R_RABIT ADORA3 Adenosine receptor A3 1.107e-106 0.35
G3PC_LEIME GAPC Glyceraldehyde-3-phosphate dehydrogenase, cytosolic 7.214e-106 0.34
DNM3B_HUMAN DNMT3B DNA (cytosine-5)-methyltransferase 3B 4.537e-105 0.44
DCAM_HUMAN AMD1 S-adenosylmethionine decarboxylase proenzyme 8.457e-105 0.43
DOT1L_HUMAN DOT1L Histone-lysine N-methyltransferase, H3 lysine-79 specific 3.908e-102 0.39
AA1R_CAVPO ADORA1 Adenosine receptor A1 1.989e-99 0.58
IMDH1_HUMAN IMPDH1 Inosine-5'-monophosphate dehydrogenase 1 3.244e-91 0.39
P2RY1_RAT P2ry1 P2Y purinoceptor 1 1.621e-90 0.44
P2RY1_MELGA P2RY1 P2Y purinoceptor 1 1.806e-88 0.44
MTAP_MOUSE Mtap S-methyl-5'-thioadenosine phosphorylase 2.395e-88 0.40
SAHH_HUMAN AHCY Adenosylhomocysteinase 2.046e-79 0.44
G3P_HUMAN GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1.128e-74 0.58
BIP_HUMAN HSPA5 Endoplasmic reticulum chaperone BiP 2.385e-71 0.42
SAHH_RAT Ahcy Adenosylhomocysteinase 1.532e-69 0.37
ASNS_HUMAN ASNS Asparagine synthetase [glutamine-hydrolyzing] 3.81e-69 0.38
P2Y11_HUMAN P2RY11 P2Y purinoceptor 11 8.924e-69 0.40
RASK_HUMAN KRAS GTPase KRas 1.379e-68 0.37
SPEE_HUMAN SRM Spermidine synthase 2.544e-68 0.35
SYQ_HUMAN QARS1 Glutamine--tRNA ligase 1.281e-66 0.40
KAD2_RAT Ak2 Adenylate kinase 2, mitochondrial 5.349e-66 0.40
IMDH2_MOUSE Impdh2 Inosine-5'-monophosphate dehydrogenase 2 6.234e-64 0.36
IF4E_RABIT EIF4E Eukaryotic translation initiation factor 4E 2.739e-63 0.40
ADK_HUMAN ADK Adenosine kinase 4.101e-62 0.51
P96884_MYCTO birA BirA bifunctional protein 4.677e-62 0.33
Q99MI5_RAT LOC100912604 Spermidine synthase 5.359e-62 0.35
PQSA_PSEAE pqsA Anthranilate--CoA ligase 1.255e-60 0.39
KAD3_RAT Ak3 GTP:AMP phosphotransferase AK3, mitochondrial 1.958e-60 0.40
KTHY_HUMAN DTYMK Thymidylate kinase 1.623e-59 0.35
HSP7C_HUMAN HSPA8 Heat shock cognate 71 kDa protein 5.321e-57 0.41
DHE3_BOVIN GLUD1 Glutamate dehydrogenase 1, mitochondrial 1.214e-56 0.36
ADRB2_MESAU ADRB2 Beta-2 adrenergic receptor 1.17e-54 0.34
SYRC_HUMAN RARS1 Arginine--tRNA ligase, cytoplasmic 2.676e-54 0.34
PANE_ECOLI panE 2-dehydropantoate 2-reductase 1.105e-53 0.34
NADK1_LISMF nadK1 NAD kinase 1 1.507e-53 0.43
NADK_STAAC nadK NAD kinase 1.507e-53 0.43
FUT6_HUMAN FUT6 Alpha-(1,3)-fucosyltransferase 6 1.803e-53 0.31
SPSY_HUMAN SMS Spermine synthase 3.621e-53 0.34
NADK_HUMAN NADK NAD kinase 8.827e-53 0.37
ADA_MOUSE Ada Adenosine deaminase 4.194e-51 0.34
ENPL_PIG HSP90B1 Endoplasmin 6.625e-51 0.41
P2RX1_HUMAN P2RX1 P2X purinoceptor 1 9.838e-51 0.42
MACD1_HUMAN MACROD1 ADP-ribose glycohydrolase MACROD1 6.374e-50 0.40
MACD2_HUMAN MACROD2 ADP-ribose glycohydrolase MACROD2 6.374e-50 0.40
CDD_MOUSE Cda Cytidine deaminase 7.738e-50 0.40
P2RX5_RAT P2rx5 P2X purinoceptor 5 1.462e-49 0.42
P2RX6_RAT P2rx6 P2X purinoceptor 6 1.462e-49 0.42
ENTE_ECOLI entE Enterobactin synthase component E 2.141e-49 0.31
RNAS1_HUMAN RNASE1 Ribonuclease pancreatic 4.661e-49 0.32
RNAS2_HUMAN RNASE2 Non-secretory ribonuclease 4.661e-49 0.32
SYS_ECOLI serS Serine--tRNA ligase 4.918e-49 0.39
HSP7C_BOVIN HSPA8 Heat shock cognate 71 kDa protein 5.887e-49 0.39
WALK_STAAU walK Sensor protein kinase WalK 5.887e-49 0.39
RNAS1_BOVIN RNASE1 Ribonuclease pancreatic 6.29e-49 0.35
SETD2_HUMAN SETD2 Histone-lysine N-methyltransferase SETD2 1.87e-48 0.39
KMT5C_HUMAN KMT5C Histone-lysine N-methyltransferase KMT5C 2.433e-48 0.38
SETB1_HUMAN SETDB1 Histone-lysine N-methyltransferase SETDB1 2.433e-48 0.38
METK2_RAT Mat2a S-adenosylmethionine synthase isoform type-2 4.174e-48 0.38
P2RY4_RAT P2ry4 P2Y purinoceptor 4 4.669e-48 0.40
MSHC_MYCTU mshC L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase 1.572e-47 0.38
Q9HWG3_PSEAE pchD Pyochelin biosynthesis protein PchD 2.461e-47 0.38
ENPP1_RAT Enpp1 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 3.866e-47 0.39
SYD_ECOLI aspS Aspartate--tRNA ligase 6.959e-46 0.36
IMDH2_HUMAN IMPDH2 Inosine-5'-monophosphate dehydrogenase 2 5.802e-45 0.39
SAHH_PLAF7 Adenosylhomocysteinase 1.052e-44 0.35
SAHH_MOUSE Ahcy Adenosylhomocysteinase 2.649e-44 0.35
ADCY2_RAT Adcy2 Adenylate cyclase type 2 2.987e-44 0.33
RN5A_HUMAN RNASEL 2-5A-dependent ribonuclease 6.315e-44 0.35
SYY_ECOLI tyrS Tyrosine--tRNA ligase 2.2e-43 0.34
HARS1_HUMAN HARS1 Histidine--tRNA ligase, cytoplasmic 1.846e-42 0.34
AA2AR_MOUSE Adora2a Adenosine receptor A2a 7.878e-42 0.34
I6YFP0_MYCTU birA Possible bifunctional protein BirA: biotin operon repressor + biotin--[acetyl-CoA-carboxylase] synthetase (Biotin--protein ligase) 9.305e-42 0.32
BIRA_ECOLI birA Bifunctional ligase/repressor BirA 1.371e-41 0.33
ADA_BOVIN ADA Adenosine deaminase 1.026e-40 0.53
METK1_RAT Mat1a S-adenosylmethionine synthase isoform type-1 3.531e-40 0.34
PUR6_CHICK AIRC Multifunctional protein ADE2 6.716e-40 0.31
Q4VQ11_PIG Adenosine receptor A1 4.617e-37 0.43
POLG_POL1M Genome polyprotein 9.406e-37 0.29
UBA7_HUMAN UBA7 Ubiquitin-like modifier-activating enzyme 7 1.046e-36 0.29
TMIG3_HUMAN TMIGD3 Transmembrane domain-containing protein TMIGD3 7.301e-36 0.41
PARG_BOVIN PARG Poly(ADP-ribose) glycohydrolase 3.2e-35 0.35
SYIC_HUMAN IARS1 Isoleucine--tRNA ligase, cytoplasmic 2.701e-34 0.41
ITPR1_RAT Itpr1 Inositol 1,4,5-trisphosphate receptor type 1 3.722e-34 0.38
PYRF_YEAST URA3 Orotidine 5'-phosphate decarboxylase 3.936e-33 0.35
ANM7_HUMAN PRMT7 Protein arginine N-methyltransferase 7 7.558e-32 0.40
GPR17_HUMAN GPR17 Uracil nucleotide/cysteinyl leukotriene receptor 1.526e-31 0.38
AA3R_MOUSE Adora3 Adenosine receptor A3 4.64e-31 0.34
DNMT1_HUMAN DNMT1 DNA (cytosine-5)-methyltransferase 1 8.089e-31 0.44
S29A1_RAT Slc29a1 Equilibrative nucleoside transporter 1 8.627e-31 0.38
SYL_ECOLI leuS Leucine--tRNA ligase 2.17e-30 0.38
PSA_HUMAN NPEPPS Puromycin-sensitive aminopeptidase 3.078e-30 0.34
PARP1_MOUSE Parp1 Poly [ADP-ribose] polymerase 1 6.001e-29 0.35
RN5A_MOUSE Rnasel 2-5A-dependent ribonuclease 3.19e-28 0.35
ADCY5_RAT Adcy5 Adenylate cyclase type 5 2.411e-27 0.41
ADA_HUMAN ADA Adenosine deaminase 4.271e-27 0.45
P2RX4_MOUSE P2rx4 P2X purinoceptor 4 1.876e-26 0.42
AMPD1_RABIT AMPD1 AMP deaminase 1 2.505e-26 0.32
CDK12_HUMAN CDK12 Cyclin-dependent kinase 12 4.502e-26 0.32
FIMH_ECOLI fimH Type 1 fimbrin D-mannose specific adhesin 5.624e-26 0.35
SYMC_HUMAN MARS1 Methionine--tRNA ligase, cytoplasmic 1.32e-25 0.40
PYGM_RABIT PYGM Glycogen phosphorylase, muscle form 1.731e-25 0.36
NNMT_HUMAN NNMT Nicotinamide N-methyltransferase 2.334e-25 0.35
SUV91_HUMAN SUV39H1 Histone-lysine N-methyltransferase SUV39H1 3.719e-25 0.38
AA1R_MOUSE Adora1 Adenosine receptor A1 2.134e-24 0.43
CDD_HUMAN CDA Cytidine deaminase 6.568e-24 0.34
SETD7_HUMAN SETD7 Histone-lysine N-methyltransferase SETD7 1.104e-23 0.39
UBA6_HUMAN UBA6 Ubiquitin-like modifier-activating enzyme 6 1.239e-23 0.29
BPL1_HUMAN HLCS Biotin--protein ligase 1.67e-23 0.33
SYI_ECOLI ileS Isoleucine--tRNA ligase 1.688e-23 0.38
ANM1_HUMAN PRMT1 Protein arginine N-methyltransferase 1 2.272e-23 0.39
KITH_RAT Tk1 Thymidine kinase, cytosolic 3.536e-23 0.37
Q3ZDS5_9HEPC NS5B 4.989e-23 0.28
P2RX4_RAT P2rx4 P2X purinoceptor 4 5.891e-23 0.42
PANC_MYCTU panC Pantothenate synthetase 1.458e-22 0.40
ENPP1_HUMAN ENPP1 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 1.55e-22 0.43
P2RX4_HUMAN P2RX4 P2X purinoceptor 4 3.69e-22 0.42
PARG_HUMAN PARG Poly(ADP-ribose) glycohydrolase 7.766e-22 0.35
AA2AR_CAVPO ADORA2A Adenosine receptor A2a 9.347e-22 0.58
MGMT_HUMAN MGMT Methylated-DNA--protein-cysteine methyltransferase 3.811e-21 0.30
AA1R_BOVIN ADORA1 Adenosine receptor A1 7.558e-21 0.58
IF4E_MOUSE Eif4e Eukaryotic translation initiation factor 4E 8.667e-21 0.33
P2RX1_RAT P2rx1 P2X purinoceptor 1 2.002e-20 0.44
PLCG1_HUMAN PLCG1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 3.109e-19 0.41
KITH_VZVD TK Thymidine kinase 3.836e-19 0.29
Q8TA74_HEMPU Ryanodine receptor 7.773e-18 0.28
DCAM_RAT Amd1 S-adenosylmethionine decarboxylase proenzyme 1.773e-17 0.41
P2RY2_HUMAN P2RY2 P2Y purinoceptor 2 2.519e-17 0.44
Q9HX69_PSEAE rocR RocR 3.331e-16 0.31
TPMT_HUMAN TPMT Thiopurine S-methyltransferase 6.661e-16 0.39
IUNH_CRIFA IUNH Inosine-uridine preferring nucleoside hydrolase 9.992e-16 0.30
O15727_TRYBB Inosine-adenosine-guanosine-nucleoside hydrolase 9.992e-16 0.30
P2RY1_HUMAN P2RY1 P2Y purinoceptor 1 9.992e-16 0.44
EZH1_HUMAN EZH1 Histone-lysine N-methyltransferase EZH1 1.554e-15 0.38
SAHH2_HUMAN AHCYL1 S-adenosylhomocysteine hydrolase-like protein 1 1.887e-15 0.29
A0A0E7NXW5_STAAU birA Bifunctional ligase/repressor BirA 4.885e-15 0.33
SYTC_HUMAN TARS1 Threonine--tRNA ligase 1, cytoplasmic 1.299e-14 0.39
5NTD_HUMAN NT5E 5'-nucleotidase 1.61e-14 0.39
CYAA_BACAN cya Calmodulin-sensitive adenylate cyclase 1.853e-13 0.34
ADH1A_HUMAN ADH1A Alcohol dehydrogenase 1A 3.113e-13 0.37
HPPK_ECOLI folK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase 3.592e-13 0.36
RAC1_HUMAN RAC1 Ras-related C3 botulinum toxin substrate 1 4.482e-13 0.39
RAB7A_HUMAN RAB7A Ras-related protein Rab-7a 2.69e-12 0.39
CDC42_HUMAN CDC42 Cell division control protein 42 homolog 3.708e-12 0.39
TYPH_HUMAN TYMP Thymidine phosphorylase 4.587e-12 0.33
CCNK_HUMAN CCNK Cyclin-K 6.43e-12 0.32
KAPCA_HUMAN PRKACA cAMP-dependent protein kinase catalytic subunit alpha 7.42e-12 0.36
DPOG1_HUMAN POLG DNA polymerase subunit gamma-1 3.882e-11 0.30
PDCD4_HUMAN PDCD4 Programmed cell death protein 4 5.931e-11 0.37
KMT2A_HUMAN KMT2A Histone-lysine N-methyltransferase 2A 1.135e-10 0.38
P2RX2_RAT P2rx2 P2X purinoceptor 2 1.648e-10 0.42
M9TGV3_MYCTX inhA Enoyl-[acyl-carrier-protein] reductase [NADH] 2.34e-10 0.35
P2RY6_HUMAN P2RY6 P2Y purinoceptor 6 3.183e-10 0.32
EHMT1_HUMAN EHMT1 Histone-lysine N-methyltransferase EHMT1 5.761e-10 0.39
DCPS_HUMAN DCPS m7GpppX diphosphatase 1.398e-09 0.40
DPOLB_HUMAN POLB DNA polymerase beta 1.408e-09 0.30
E1BN64_BOVIN PDE3B Phosphodiesterase 2.944e-09 0.31
PUR9_HUMAN ATIC Bifunctional purine biosynthesis protein PURH 4.054e-09 0.34
KITH_HUMAN TK1 Thymidine kinase, cytosolic 5.999e-09 0.30
INMT_HUMAN INMT Indolethylamine N-methyltransferase 7.844e-09 0.38
PARG_RAT Parg Poly(ADP-ribose) glycohydrolase 8.253e-09 0.35
LEG7_HUMAN LGALS7; LGALS7B Galectin-7 1.164e-08 0.32
P2RY4_HUMAN P2RY4 P2Y purinoceptor 4 1.275e-08 0.32
ADK_RAT Adk Adenosine kinase 2.664e-08 0.42
5NTD_RAT Nt5e 5'-nucleotidase 3.459e-08 0.39
Q9Y0I0_9TRYP AT1 Adenosine transporter 1 4.531e-08 0.36
P2Y12_RAT P2ry12 P2Y purinoceptor 12 6.25e-08 0.42
SYT_YERPE thrS Threonine--tRNA ligase 1.134e-07 0.39
HS71A_HUMAN HSPA1A Heat shock 70 kDa protein 1A 1.178e-07 0.38
EZH2_HUMAN EZH2 Histone-lysine N-methyltransferase EZH2 2.388e-07 0.38
LEG9_HUMAN LGALS9 Galectin-9 2.762e-07 0.32
ENPL_CANLF HSP90B1 Endoplasmin 5.21e-07 0.38
LUCI_AQULA Luciferin 4-monooxygenase 8.612e-07 0.34
MAT1_HUMAN MNAT1 CDK-activating kinase assembly factor MAT1 9.911e-07 0.32
GRK1_HUMAN GRK1 Rhodopsin kinase GRK1 1.08e-06 0.41
Q72547_9HIV1 pol Reverse transcriptase/RNaseH 2.723e-06 0.41
PYGM_HUMAN PYGM Glycogen phosphorylase, muscle form 2.867e-06 0.31
DHB1_HUMAN HSD17B1 Estradiol 17-beta-dehydrogenase 1 5.854e-06 0.29
CAH14_HUMAN CA14 Carbonic anhydrase 14 7.348e-06 0.33
Q56950_YERPE ybtE Salicyl-AMP ligase YbtE 7.83e-06 0.38

Rivaroxaban

FA10_RABIT F10 Coagulation factor X 3.482e-163 1.00
FA10_HUMAN F10 Coagulation factor X 6.644e-76 1.00
ST14_HUMAN ST14 Suppressor of tumorigenicity 14 protein 0.002412 1.00
CP2J2_HUMAN CYP2J2 Cytochrome P450 2J2 1.134e-13 0.72
AOFA_BOVIN MAOA Amine oxidase [flavin-containing] A 4.36e-12 0.37
LPXC_ECOLI lpxC UDP-3-O-acyl-N-acetylglucosamine deacetylase 1.99e-11 0.38
GRM2_HUMAN GRM2 Metabotropic glutamate receptor 2 6.439e-10 0.36
THAS_RAT Tbxas1 Thromboxane-A synthase 1.822e-09 0.33
THRB_HUMAN F2 Prothrombin 3.968e-07 0.60
SGMR1_HUMAN SIGMAR1 Sigma non-opioid intracellular receptor 1 4.155e-06 0.34

Lasofoxifene

ESR1_HUMAN ESR1 Estrogen receptor 2.896e-157 1.00
ESR2_HUMAN ESR2 Estrogen receptor beta 9.599e-151 1.00
HRH3_HUMAN HRH3 Histamine H3 receptor 5.628e-103 0.44
LKHA4_HUMAN LTA4H Leukotriene A-4 hydrolase 4.348e-92 0.46
PSB1_HUMAN PSMB1 Proteasome subunit beta type-1 1.409e-51 0.45
SC6A1_RAT Slc6a1 Sodium- and chloride-dependent GABA transporter 1 2.871e-49 0.33
DRD5_HUMAN DRD5 D(1B) dopamine receptor 4.54e-49 0.35
PPARG_MOUSE Pparg Peroxisome proliferator-activated receptor gamma 1.987e-48 0.34
HRH3_MOUSE Hrh3 Histamine H3 receptor 2.391e-44 0.40
LKHA4_MOUSE Lta4h Leukotriene A-4 hydrolase 4.665e-40 0.39
DRD1_HUMAN DRD1 D(1A) dopamine receptor 1.809e-38 0.37
CHLE_HORSE BCHE Cholinesterase 1.612e-37 0.40
MEN1_HUMAN MEN1 Menin 3.114e-37 0.32
ESR1_RAT Esr1 Estrogen receptor 5.583e-36 0.39
GGYF2_HUMAN GIGYF2 GRB10-interacting GYF protein 2 1.264e-35 0.28
ACES_ELEEL ache Acetylcholinesterase 6.112e-35 0.40
NORA_STAAU norA Quinolone resistance protein NorA 2.898e-34 0.38
PSB2_HUMAN PSMB2 Proteasome subunit beta type-2 2.034e-32 0.41
DRD1_RAT Drd1 D(1A) dopamine receptor 2.75e-31 0.45
HNMT_RAT Hnmt Histamine N-methyltransferase 6.42e-31 0.33
HRH3_CAVPO HRH3 Histamine H3 receptor 2.051e-30 0.37
DRD2_RAT Drd2 D(2) dopamine receptor 7.458e-30 0.40
CHLE_MOUSE Bche Cholinesterase 2.507e-28 0.29
ESR2_RAT Esr2 Estrogen receptor beta 6.898e-28 0.38
SC6A9_HUMAN SLC6A9 Sodium- and chloride-dependent glycine transporter 1 1.466e-26 0.39
HRH3_RAT Hrh3 Histamine H3 receptor 1.502e-26 0.39
EBP_CAVPO EBP 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase 3.183e-25 0.36
Q6A2E2_AEDAE ace-1 Acetylcholinesterase 3.637e-25 0.31
NMDE2_HUMAN GRIN2B Glutamate receptor ionotropic, NMDA 2B 1.218e-24 0.48
PPARA_HUMAN PPARA Peroxisome proliferator-activated receptor alpha 1.462e-24 0.35
ADCY5_RAT Adcy5 Adenylate cyclase type 5 1.638e-23 0.34
CP24A_RAT Cyp24a1 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial 2.686e-23 0.30
SGMR1_CAVPO SIGMAR1 Sigma non-opioid intracellular receptor 1 2.803e-23 0.48
NMDZ1_HUMAN GRIN1 Glutamate receptor ionotropic, NMDA 1 9.313e-23 0.48
BMP4_HUMAN BMP4 Bone morphogenetic protein 4 3.993e-22 0.33
MMP15_HUMAN MMP15 Matrix metalloproteinase-15 1.461e-21 0.30
HRH1_HUMAN HRH1 Histamine H1 receptor 1.554e-21 0.39
SC6A4_RAT Slc6a4 Sodium-dependent serotonin transporter 1.709e-21 0.42
DRD2_HUMAN DRD2 D(2) dopamine receptor 1.756e-21 0.37
PSB5_HUMAN PSMB5 Proteasome subunit beta type-5 2.41e-21 0.45
MMP26_HUMAN MMP26 Matrix metalloproteinase-26 6.098e-21 0.30
ACK1_MOUSE Tnk2 Activated CDC42 kinase 1 2.967e-20 0.31
SO1A1_RAT Slco1a1 Solute carrier organic anion transporter family member 1A1 1.227e-19 0.29
SGMR1_HUMAN SIGMAR1 Sigma non-opioid intracellular receptor 1 5.571e-19 0.39
PPARD_HUMAN PPARD Peroxisome proliferator-activated receptor delta 3.99e-18 0.38
S22A3_RAT Slc22a3 Solute carrier family 22 member 3 4.879e-18 0.29
TYRP1_MOUSE Tyrp1 5,6-dihydroxyindole-2-carboxylic acid oxidase 4.879e-18 0.29
DRD3_RAT Drd3 D(3) dopamine receptor 2.229e-17 0.38
SGMR1_RAT Sigmar1 Sigma non-opioid intracellular receptor 1 3.054e-17 0.40
ACES_MOUSE Ache Acetylcholinesterase 4.441e-16 0.30
PPARG_HUMAN PPARG Peroxisome proliferator-activated receptor gamma 9.992e-16 0.35
NMD3A_RAT Grin3a Glutamate receptor ionotropic, NMDA 3A 1.443e-15 0.47
ANM6_HUMAN PRMT6 Protein arginine N-methyltransferase 6 2.776e-15 0.32
H10_HUMAN H1-0 Histone H1.0 8.105e-15 0.28
STS_HUMAN STS Steryl-sulfatase 1.277e-14 0.37
DRD3_HUMAN DRD3 D(3) dopamine receptor 2.265e-14 0.36
5HT7R_HUMAN HTR7 5-hydroxytryptamine receptor 7 2.431e-14 0.36
KCNH2_HUMAN KCNH2 Potassium voltage-gated channel subfamily H member 2 3.031e-14 0.42
HRH1_CAVPO HRH1 Histamine H1 receptor 5.229e-14 0.33
SC6A4_HUMAN SLC6A4 Sodium-dependent serotonin transporter 6.795e-14 0.38
CBG_HUMAN SERPINA6 Corticosteroid-binding globulin 6.939e-14 0.30
UR2R_HUMAN UTS2R Urotensin-2 receptor 2.154e-13 0.31
Q9HUN3_PSEAE dnaB Replicative DNA helicase 2.701e-13 0.29
YES_HUMAN YES1 Tyrosine-protein kinase Yes 4.358e-13 0.35
SNRK_HUMAN SNRK SNF-related serine/threonine-protein kinase 4.607e-13 0.28
NPY1R_HUMAN NPY1R Neuropeptide Y receptor type 1 7.117e-13 0.39
TLR9_HUMAN TLR9 Toll-like receptor 9 9.002e-13 0.36
CARM1_HUMAN CARM1 Histone-arginine methyltransferase CARM1 9.707e-13 0.32
MMP16_HUMAN MMP16 Matrix metalloproteinase-16 5.283e-12 0.30
GPER1_HUMAN GPER1 G-protein coupled estrogen receptor 1 9.7e-12 0.29
AOFB_HUMAN MAOB Amine oxidase [flavin-containing] B 1.261e-11 0.36
SC6A1_HUMAN SLC6A1 Sodium- and chloride-dependent GABA transporter 1 1.322e-11 0.30
S1PR5_HUMAN S1PR5 Sphingosine 1-phosphate receptor 5 2.119e-11 0.30
MCHR1_HUMAN MCHR1 Melanin-concentrating hormone receptor 1 4.773e-11 0.42
DRD4_RAT Drd4 D(4) dopamine receptor 9.123e-11 0.33
NMDE3_RAT Grin2c Glutamate receptor ionotropic, NMDA 2C 1.202e-10 0.31
NEK3_HUMAN NEK3 Serine/threonine-protein kinase Nek3 1.257e-10 0.28
5HT1A_RAT Htr1a 5-hydroxytryptamine receptor 1A 1.928e-10 0.35
HRH2_HUMAN HRH2 Histamine H2 receptor 3.282e-10 0.33
NMDE4_RAT Grin2d Glutamate receptor ionotropic, NMDA 2D 4.177e-10 0.31
ACK1_HUMAN TNK2 Activated CDC42 kinase 1 7.057e-10 0.32
ACES_HUMAN ACHE Acetylcholinesterase 7.537e-10 0.37
JAK3_MOUSE Jak3 Tyrosine-protein kinase JAK3 8.49e-10 0.28
NEK11_HUMAN NEK11 Serine/threonine-protein kinase Nek11 8.49e-10 0.28
DRD4_HUMAN DRD4 D(4) dopamine receptor 1.122e-09 0.35
DHB1_HUMAN HSD17B1 Estradiol 17-beta-dehydrogenase 1 1.207e-09 0.35
MCHR1_MOUSE Mchr1 Melanin-concentrating hormone receptor 1 1.479e-09 0.29
BMPR2_HUMAN BMPR2 Bone morphogenetic protein receptor type-2 1.554e-09 0.30
ERG2_YEAST ERG2 C-8 sterol isomerase 1.86e-09 0.39
NAC1_HUMAN SLC8A1 Sodium/calcium exchanger 1 2.398e-09 0.33
ESR1_MOUSE Esr1 Estrogen receptor 3.598e-09 0.29
ESR2_MOUSE Esr2 Estrogen receptor beta 3.598e-09 0.29
STK38_HUMAN STK38 Serine/threonine-protein kinase 38 4.015e-09 0.28
Q63380_RAT NET Transporter 6.377e-09 0.39
NMDE2_RAT Grin2b Glutamate receptor ionotropic, NMDA 2B 8.403e-09 0.53
SHBG_HUMAN SHBG Sex hormone-binding globulin 1.057e-08 0.31
ACES_ANOGA Ace Acetylcholinesterase 1.292e-08 0.31
MET_HUMAN MET Hepatocyte growth factor receptor 1.387e-08 0.36
MK06_HUMAN MAPK6 Mitogen-activated protein kinase 6 1.464e-08 0.28
5HT3A_RAT Htr3a 5-hydroxytryptamine receptor 3A 1.609e-08 0.30
DRD2_BOVIN DRD2 D(2) dopamine receptor 1.796e-08 0.34
5HT1A_HUMAN HTR1A 5-hydroxytryptamine receptor 1A 2.041e-08 0.35
5HT2B_HUMAN HTR2B 5-hydroxytryptamine receptor 2B 2.153e-08 0.33
ANM8_HUMAN PRMT8 Protein arginine N-methyltransferase 8 2.261e-08 0.29
SRC_HUMAN SRC Proto-oncogene tyrosine-protein kinase Src 2.425e-08 0.37
NMDZ1_RAT Grin1 Glutamate receptor ionotropic, NMDA 1 2.689e-08 0.53
5HT2A_HUMAN HTR2A 5-hydroxytryptamine receptor 2A 2.928e-08 0.36
EBP_HUMAN EBP 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase 4.248e-08 0.39
NEK9_HUMAN NEK9 Serine/threonine-protein kinase Nek9 4.387e-08 0.28
TLK2_HUMAN TLK2 Serine/threonine-protein kinase tousled-like 2 4.387e-08 0.28
KCNA5_HUMAN KCNA5 Potassium voltage-gated channel subfamily A member 5 9.567e-08 0.36
CDKL5_HUMAN CDKL5 Cyclin-dependent kinase-like 5 1.129e-07 0.28
COQ8A_HUMAN COQ8A Atypical kinase COQ8A, mitochondrial 1.129e-07 0.28
CSKP_HUMAN CASK Peripheral plasma membrane protein CASK 1.129e-07 0.28
STK39_HUMAN STK39 STE20/SPS1-related proline-alanine-rich protein kinase 1.129e-07 0.28
A5A4K8_RABIT MLNR Motilin receptor 1.192e-07 0.30
ABL1_MOUSE Abl1 Tyrosine-protein kinase ABL1 1.426e-07 0.32
BMR1B_HUMAN BMPR1B Bone morphogenetic protein receptor type-1B 2.228e-07 0.30
CPT2_RAT Cpt2 Carnitine O-palmitoyltransferase 2, mitochondrial 2.288e-07 0.29
DCLK2_HUMAN DCLK2 Serine/threonine-protein kinase DCLK2 2.575e-07 0.28
Q690N0_BOVIN PGR Progesterone receptor 2.668e-07 0.30
TGFR2_HUMAN TGFBR2 TGF-beta receptor type-2 3.275e-07 0.30
COQ8B_HUMAN COQ8B Atypical kinase COQ8B, mitochondrial 5.325e-07 0.28
NEK5_HUMAN NEK5 Serine/threonine-protein kinase Nek5 5.325e-07 0.28
NEK7_HUMAN NEK7 Serine/threonine-protein kinase Nek7 5.325e-07 0.28
SBK3_HUMAN SBK3 Uncharacterized serine/threonine-protein kinase SBK3 5.325e-07 0.28
SIK3_HUMAN SIK3 Serine/threonine-protein kinase SIK3 5.325e-07 0.28
SRPK2_HUMAN SRPK2 SRSF protein kinase 2 5.325e-07 0.28
STK11_HUMAN STK11 Serine/threonine-protein kinase STK11 5.325e-07 0.28
TLK1_HUMAN TLK1 Serine/threonine-protein kinase tousled-like 1 5.325e-07 0.28
TYTR_TRYBB TPR Trypanothione reductase 5.91e-07 0.32
PGFRA_MOUSE Pdgfra Platelet-derived growth factor receptor alpha 6.718e-07 0.32
NIM1_HUMAN NIM1K Serine/threonine-protein kinase NIM1 1.016e-06 0.28
PRP4B_HUMAN PRPF4B Serine/threonine-protein kinase PRP4 homolog 1.016e-06 0.28
WEE2_HUMAN WEE2 Wee1-like protein kinase 2 1.016e-06 0.28
SOAT1_RAT Soat1 Sterol O-acyltransferase 1 1.122e-06 0.40
Q865E1_MACMU HRH3 Histamine receptor H3 1.152e-06 0.32
ACH10_RAT Chrna10 Neuronal acetylcholine receptor subunit alpha-10 1.355e-06 0.29
ERR2_HUMAN ESRRB Steroid hormone receptor ERR2 1.402e-06 0.29
KDM1A_HUMAN KDM1A Lysine-specific histone demethylase 1A 1.681e-06 0.32
CDK15_HUMAN CDK15 Cyclin-dependent kinase 15 1.815e-06 0.28
SGK3_HUMAN SGK3 Serine/threonine-protein kinase Sgk3 1.815e-06 0.28
5HT5A_HUMAN HTR5A 5-hydroxytryptamine receptor 5A 2.495e-06 0.30
S22A3_HUMAN SLC22A3 Solute carrier family 22 member 3 2.849e-06 0.29
VACHT_HUMAN SLC18A3 Vesicular acetylcholine transporter 2.952e-06 0.32
5HT2A_PIG HTR2A 5-hydroxytryptamine receptor 2A 2.972e-06 0.29
CDK18_HUMAN CDK18 Cyclin-dependent kinase 18 3.063e-06 0.28
KCC1G_HUMAN CAMK1G Calcium/calmodulin-dependent protein kinase type 1G 3.063e-06 0.28
SBK1_HUMAN SBK1 Serine/threonine-protein kinase SBK1 3.063e-06 0.28
PGFRB_MOUSE Pdgfrb Platelet-derived growth factor receptor beta 3.613e-06 0.32
5HT2A_RAT Htr2a 5-hydroxytryptamine receptor 2A 3.796e-06 0.35
5HT3A_HUMAN HTR3A 5-hydroxytryptamine receptor 3A 3.831e-06 0.33
SC6A1_MOUSE Slc6a1 Sodium- and chloride-dependent GABA transporter 1 4.907e-06 0.30
NEK6_HUMAN NEK6 Serine/threonine-protein kinase Nek6 4.928e-06 0.28
PAK6_HUMAN PAK6 Serine/threonine-protein kinase PAK 6 4.928e-06 0.28
RIPK4_HUMAN RIPK4 Receptor-interacting serine/threonine-protein kinase 4 4.928e-06 0.28
KS6A1_HUMAN RPS6KA1 Ribosomal protein S6 kinase alpha-1 5.746e-06 0.30
HRH2_CAVPO HRH2 Histamine H2 receptor 6.065e-06 0.31
AAKB1_HUMAN PRKAB1 5'-AMP-activated protein kinase subunit beta-1 6.85e-06 0.32
DRD1_MOUSE Drd1 D(1A) dopamine receptor 7.451e-06 0.30
CILK1_HUMAN CILK1 Serine/threonine-protein kinase ICK 7.607e-06 0.28
INSRR_HUMAN INSRR Insulin receptor-related protein 7.607e-06 0.28
M3K4_HUMAN MAP3K4 Mitogen-activated protein kinase kinase kinase 4 7.607e-06 0.28
MYLK3_HUMAN MYLK3 Myosin light chain kinase 3 7.607e-06 0.28
MYLK4_HUMAN MYLK4 Myosin light chain kinase family member 4 7.607e-06 0.28
BMR1A_HUMAN BMPR1A Bone morphogenetic protein receptor type-1A 7.965e-06 0.30
SGMR2_RAT Tmem97 Sigma intracellular receptor 2 8.644e-06 0.36
5HT2C_RAT Htr2c 5-hydroxytryptamine receptor 2C 9.917e-06 0.32

Arzoxifene

ESR1_HUMAN ESR1 Estrogen receptor 3.362e-155 1.00
ESR2_HUMAN ESR2 Estrogen receptor beta 5.544e-127 1.00
HRH3_HUMAN HRH3 Histamine H3 receptor 1.348e-107 0.47
LKHA4_HUMAN LTA4H Leukotriene A-4 hydrolase 6.19e-88 0.47
NORA_STAAU norA Quinolone resistance protein NorA 3.225e-66 0.42
LKHA4_MOUSE Lta4h Leukotriene A-4 hydrolase 1.16e-53 0.40
PSB1_HUMAN PSMB1 Proteasome subunit beta type-1 1.131e-51 0.42
HNMT_RAT Hnmt Histamine N-methyltransferase 3.322e-47 0.34
HRH3_MOUSE Hrh3 Histamine H3 receptor 2.23e-44 0.38
ESR1_RAT Esr1 Estrogen receptor 3.773e-43 0.66
EBP_CAVPO EBP 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase 1.755e-40 0.39
BMP4_HUMAN BMP4 Bone morphogenetic protein 4 1.191e-39 0.35
ACES_ELEEL ache Acetylcholinesterase 2.879e-39 0.43
CHLE_HORSE BCHE Cholinesterase 5.484e-38 0.43
HRH3_RAT Hrh3 Histamine H3 receptor 3.436e-37 0.39
ESR2_RAT Esr2 Estrogen receptor beta 4.996e-35 0.66
PSB2_HUMAN PSMB2 Proteasome subunit beta type-2 5.186e-33 0.42
ACES_MOUSE Ache Acetylcholinesterase 5.329e-33 0.38
RAGE_HUMAN AGER Advanced glycosylation end product-specific receptor 5.849e-32 0.43
S6A11_HUMAN SLC6A11 Sodium- and chloride-dependent GABA transporter 3 1.774e-30 0.31
Q6A2E2_AEDAE ace-1 Acetylcholinesterase 2.859e-26 0.32
HRH1_HUMAN HRH1 Histamine H1 receptor 2.955e-26 0.39
S29A2_RAT Slc29a2 Equilibrative nucleoside transporter 2 5.731e-26 0.30
V1BR_HUMAN AVPR1B Vasopressin V1b receptor 1.837e-24 0.35
Q4DCQ3_TRYCC Superoxide dismutase 9.719e-24 0.29
PSB5_HUMAN PSMB5 Proteasome subunit beta type-5 1.044e-21 0.42
SGMR1_CAVPO SIGMAR1 Sigma non-opioid intracellular receptor 1 5.123e-19 0.39
MCHR1_HUMAN MCHR1 Melanin-concentrating hormone receptor 1 2.323e-17 0.43
YES_HUMAN YES1 Tyrosine-protein kinase Yes 1.11e-16 0.37
IKKB_MOUSE Ikbkb Inhibitor of nuclear factor kappa-B kinase subunit beta 2.22e-16 0.32
ROCK2_RAT Rock2 Rho-associated protein kinase 2 2.22e-16 0.34
HRH3_CAVPO HRH3 Histamine H3 receptor 3.331e-16 0.34
SRC_HUMAN SRC Proto-oncogene tyrosine-protein kinase Src 3.331e-16 0.38
KCNH2_HUMAN KCNH2 Potassium voltage-gated channel subfamily H member 2 5.551e-16 0.42
S6A13_MOUSE Slc6a13 Sodium- and chloride-dependent GABA transporter 2 3.22e-15 0.31
5HT4R_RAT Htr4 5-hydroxytryptamine receptor 4 4.108e-15 0.37
GYRB_MYCSM gyrB DNA gyrase subunit B 4.552e-15 0.35
HRH2_HUMAN HRH2 Histamine H2 receptor 7.105e-15 0.34
PGFRB_HUMAN PDGFRB Platelet-derived growth factor receptor beta 1.887e-14 0.40
5HT2B_HUMAN HTR2B 5-hydroxytryptamine receptor 2B 2.085e-13 0.41
NLRP1_HUMAN NLRP1 NACHT, LRR and PYD domains-containing protein 1 3.23e-13 0.29
SNRK_HUMAN SNRK SNF-related serine/threonine-protein kinase 6.325e-13 0.28
NMD3A_RAT Grin3a Glutamate receptor ionotropic, NMDA 3A 7.727e-12 0.35
KS6A1_HUMAN RPS6KA1 Ribosomal protein S6 kinase alpha-1 9.771e-12 0.35
S6A12_HUMAN SLC6A12 Sodium- and chloride-dependent betaine transporter 1.15e-11 0.28
HRH1_CAVPO HRH1 Histamine H1 receptor 1.956e-11 0.34
VGFR2_HUMAN KDR Vascular endothelial growth factor receptor 2 2.94e-11 0.43
PPAC_HUMAN ACP1 Low molecular weight phosphotyrosine protein phosphatase 3.367e-11 0.38
SC6A4_RAT Slc6a4 Sodium-dependent serotonin transporter 4.163e-11 0.39
MYLK3_HUMAN MYLK3 Myosin light chain kinase 3 5.507e-11 0.29
SC6A4_MOUSE Slc6a4 Sodium-dependent serotonin transporter 8.085e-11 0.31
NEK3_HUMAN NEK3 Serine/threonine-protein kinase Nek3 1.621e-10 0.28
5HT3A_RAT Htr3a 5-hydroxytryptamine receptor 3A 1.855e-10 0.39
ATM_HUMAN ATM Serine-protein kinase ATM 2.224e-10 0.29
ACK1_HUMAN TNK2 Activated CDC42 kinase 1 2.256e-10 0.33
BMPR2_HUMAN BMPR2 Bone morphogenetic protein receptor type-2 3.207e-10 0.35
JAK3_MOUSE Jak3 Tyrosine-protein kinase JAK3 3.705e-10 0.30
ACHA7_RAT Chrna7 Neuronal acetylcholine receptor subunit alpha-7 5.654e-10 0.39
FLT3_HUMAN FLT3 Receptor-type tyrosine-protein kinase FLT3 8.474e-10 0.40
5HT2C_HUMAN HTR2C 5-hydroxytryptamine receptor 2C 8.894e-10 0.41
MUSK_HUMAN MUSK Muscle, skeletal receptor tyrosine-protein kinase 9.158e-10 0.29
V1BR_RAT Avpr1b Vasopressin V1b receptor 1.049e-09 0.34
NEK11_HUMAN NEK11 Serine/threonine-protein kinase Nek11 1.072e-09 0.28
TBK1_HUMAN TBK1 Serine/threonine-protein kinase TBK1 1.205e-09 0.37
HRH2_CAVPO HRH2 Histamine H2 receptor 1.574e-09 0.32
5HT2A_HUMAN HTR2A 5-hydroxytryptamine receptor 2A 2.11e-09 0.41
ERG2_YEAST ERG2 C-8 sterol isomerase 2.536e-09 0.40
STK38_HUMAN STK38 Serine/threonine-protein kinase 38 4.981e-09 0.28
MK15_HUMAN MAPK15 Mitogen-activated protein kinase 15 7.543e-09 0.29
KCNA5_HUMAN KCNA5 Potassium voltage-gated channel subfamily A member 5 8.97e-09 0.39
EPHA7_HUMAN EPHA7 Ephrin type-A receptor 7 1.182e-08 0.29
CXCR1_HUMAN CXCR1 C-X-C chemokine receptor type 1 1.601e-08 0.33
MK06_HUMAN MAPK6 Mitogen-activated protein kinase 6 1.791e-08 0.28
SGMR1_HUMAN SIGMAR1 Sigma non-opioid intracellular receptor 1 2.16e-08 0.40
TLR9_HUMAN TLR9 Toll-like receptor 9 2.269e-08 0.38
ACES_HUMAN ACHE Acetylcholinesterase 3.413e-08 0.40
Q63380_RAT NET Transporter 3.414e-08 0.37
TIE2_HUMAN TEK Angiopoietin-1 receptor 4.431e-08 0.40
5HT2A_RAT Htr2a 5-hydroxytryptamine receptor 2A 4.525e-08 0.34
PGFRA_MOUSE Pdgfra Platelet-derived growth factor receptor alpha 5.04e-08 0.40
NEK9_HUMAN NEK9 Serine/threonine-protein kinase Nek9 5.301e-08 0.28
TLK2_HUMAN TLK2 Serine/threonine-protein kinase tousled-like 2 5.301e-08 0.28
EBP_HUMAN EBP 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase 5.526e-08 0.40
AAKB1_HUMAN PRKAB1 5'-AMP-activated protein kinase subunit beta-1 5.596e-08 0.35
BMR1B_HUMAN BMPR1B Bone morphogenetic protein receptor type-1B 6.711e-08 0.35
VGFR3_HUMAN FLT4 Vascular endothelial growth factor receptor 3 7.241e-08 0.40
5HT3A_HUMAN HTR3A 5-hydroxytryptamine receptor 3A 7.642e-08 0.39
5HT5A_MOUSE Htr5a 5-hydroxytryptamine receptor 5A 8.293e-08 0.32
SC6A4_HUMAN SLC6A4 Sodium-dependent serotonin transporter 1.348e-07 0.39
CDKL5_HUMAN CDKL5 Cyclin-dependent kinase-like 5 1.35e-07 0.28
COQ8A_HUMAN COQ8A Atypical kinase COQ8A, mitochondrial 1.35e-07 0.28
CSKP_HUMAN CASK Peripheral plasma membrane protein CASK 1.35e-07 0.28
STK39_HUMAN STK39 STE20/SPS1-related proline-alanine-rich protein kinase 1.35e-07 0.28
S6A11_MOUSE Slc6a11 Sodium- and chloride-dependent GABA transporter 3 1.377e-07 0.31
TERT_HUMAN TERT Telomerase reverse transcriptase 1.438e-07 0.34
LCK_HUMAN LCK Tyrosine-protein kinase Lck 2.388e-07 0.35
CDK16_HUMAN CDK16 Cyclin-dependent kinase 16 2.392e-07 0.28
EPHA6_HUMAN EPHA6 Ephrin type-A receptor 6 2.672e-07 0.29
ACK1_MOUSE Tnk2 Activated CDC42 kinase 1 2.735e-07 0.31
MKNK1_HUMAN MKNK1 MAP kinase-interacting serine/threonine-protein kinase 1 2.94e-07 0.35
DCLK2_HUMAN DCLK2 Serine/threonine-protein kinase DCLK2 3.05e-07 0.28
Q865E1_MACMU HRH3 Histamine receptor H3 4.116e-07 0.34
TIE1_HUMAN TIE1 Tyrosine-protein kinase receptor Tie-1 5.82e-07 0.29
COQ8B_HUMAN COQ8B Atypical kinase COQ8B, mitochondrial 6.259e-07 0.28
NEK5_HUMAN NEK5 Serine/threonine-protein kinase Nek5 6.259e-07 0.28
NEK7_HUMAN NEK7 Serine/threonine-protein kinase Nek7 6.259e-07 0.28
SBK3_HUMAN SBK3 Uncharacterized serine/threonine-protein kinase SBK3 6.259e-07 0.28
SIK3_HUMAN SIK3 Serine/threonine-protein kinase SIK3 6.259e-07 0.28
SRPK2_HUMAN SRPK2 SRSF protein kinase 2 6.259e-07 0.28
STK11_HUMAN STK11 Serine/threonine-protein kinase STK11 6.259e-07 0.28
TLK1_HUMAN TLK1 Serine/threonine-protein kinase tousled-like 1 6.259e-07 0.28
SC6A3_MOUSE Slc6a3 Sodium-dependent dopamine transporter 7.137e-07 0.31
EPHB6_HUMAN EPHB6 Ephrin type-B receptor 6 1.159e-06 0.29
HSF1_HUMAN HSF1 Heat shock factor protein 1 1.16e-06 0.30
NIM1_HUMAN NIM1K Serine/threonine-protein kinase NIM1 1.186e-06 0.28
PRP4B_HUMAN PRPF4B Serine/threonine-protein kinase PRP4 homolog 1.186e-06 0.28
WEE2_HUMAN WEE2 Wee1-like protein kinase 2 1.186e-06 0.28
BMR1A_HUMAN BMPR1A Bone morphogenetic protein receptor type-1A 1.201e-06 0.35
KCNH2_CAVPO KCNH2 Potassium voltage-gated channel subfamily H member 2 1.218e-06 0.29
DRD2_RAT Drd2 D(2) dopamine receptor 1.49e-06 0.34
CDK15_HUMAN CDK15 Cyclin-dependent kinase 15 2.104e-06 0.28
SGK3_HUMAN SGK3 Serine/threonine-protein kinase Sgk3 2.104e-06 0.28
FGFR2_HUMAN FGFR2 Fibroblast growth factor receptor 2 3.032e-06 0.33
SGMR1_RAT Sigmar1 Sigma non-opioid intracellular receptor 1 3.05e-06 0.36
CDK18_HUMAN CDK18 Cyclin-dependent kinase 18 3.531e-06 0.28
KCC1G_HUMAN CAMK1G Calcium/calmodulin-dependent protein kinase type 1G 3.531e-06 0.28
SBK1_HUMAN SBK1 Serine/threonine-protein kinase SBK1 3.531e-06 0.28
AOFB_HUMAN MAOB Amine oxidase [flavin-containing] B 4.103e-06 0.40
STK10_HUMAN STK10 Serine/threonine-protein kinase 10 4.429e-06 0.29
EPHA3_HUMAN EPHA3 Ephrin type-A receptor 3 5.233e-06 0.29
NEK6_HUMAN NEK6 Serine/threonine-protein kinase Nek6 5.652e-06 0.28
PAK6_HUMAN PAK6 Serine/threonine-protein kinase PAK 6 5.652e-06 0.28
RIPK4_HUMAN RIPK4 Receptor-interacting serine/threonine-protein kinase 4 5.652e-06 0.28
IL2_HUMAN IL2 Interleukin-2 6.262e-06 0.31
CILK1_HUMAN CILK1 Serine/threonine-protein kinase ICK 8.684e-06 0.28
INSRR_HUMAN INSRR Insulin receptor-related protein 8.684e-06 0.28
M3K4_HUMAN MAP3K4 Mitogen-activated protein kinase kinase kinase 4 8.684e-06 0.28
MYLK4_HUMAN MYLK4 Myosin light chain kinase family member 4 8.684e-06 0.28
MET_HUMAN MET Hepatocyte growth factor receptor 8.689e-06 0.33
DRD5_HUMAN DRD5 D(1B) dopamine receptor 9.676e-06 0.31

Tolvaptan

V2R_HUMAN AVPR2 Vasopressin V2 receptor 1.848e-153 1.00
V2R_RAT Avpr2 Vasopressin V2 receptor 2.977e-138 0.66
V1AR_RAT Avpr1a Vasopressin V1a receptor 5.099e-120 0.66
V1AR_HUMAN AVPR1A Vasopressin V1a receptor 8.984e-72 0.66
GRM4_RAT Grm4 Metabotropic glutamate receptor 4 2.091e-65 0.41
LIPL_BOVIN LPL Lipoprotein lipase 1.973e-57 0.33
APOB_HUMAN APOB Apolipoprotein B-100 4.094e-52 0.36
Q8T8E9_9TRYP galE UDP-galactose 4-epimerase 2.676e-49 0.37
NPY2R_HUMAN NPY2R Neuropeptide Y receptor type 2 3.595e-47 0.36
GRM1_HUMAN GRM1 Metabotropic glutamate receptor 1 9.705e-46 0.37
CCR8_HUMAN CCR8 C-C chemokine receptor type 8 1.222e-44 0.33
GRM4_HUMAN GRM4 Metabotropic glutamate receptor 4 1.059e-42 0.41
CPT2_HUMAN CPT2 Carnitine O-palmitoyltransferase 2, mitochondrial 1.631e-42 0.33
ACKR3_HUMAN ACKR3 Atypical chemokine receptor 3 1.242e-38 0.42
CPT1B_HUMAN CPT1B Carnitine O-palmitoyltransferase 1, muscle isoform 1.549e-38 0.33
Q865E1_MACMU HRH3 Histamine receptor H3 7.068e-38 0.39
ENTP1_RAT Entpd1 Ectonucleoside triphosphate diphosphohydrolase 1 5.953e-37 0.29
CPT2_RAT Cpt2 Carnitine O-palmitoyltransferase 2, mitochondrial 1.234e-36 0.33
PSBA_SPIOL psbA Photosystem II protein D1 9.971e-33 0.31
RXFP1_HUMAN RXFP1 Relaxin receptor 1 7.131e-32 0.37
MTP_HUMAN MTTP Microsomal triglyceride transfer protein large subunit 6.856e-31 0.36
Q9GSG8_AEDAE Ultraspiracle isoform-A 1.657e-30 0.31
ECR_AEDAE EcR Ecdysone receptor 6.698e-30 0.36
EFC4B_HUMAN CRACR2A EF-hand calcium-binding domain-containing protein 4B 8.283e-30 0.42
KCNK9_HUMAN KCNK9 Potassium channel subfamily K member 9 1.948e-29 0.38
WDR5_HUMAN WDR5 WD repeat-containing protein 5 1.026e-28 0.33
NPY5R_RAT Npy5r Neuropeptide Y receptor type 5 7.858e-28 0.32
BXE_CLOBO botE Botulinum neurotoxin type E 6.603e-27 0.37
FADS1_HUMAN FADS1 Acyl-CoA (8-3)-desaturase 3.433e-26 0.35
TMPS4_HUMAN TMPRSS4 Transmembrane protease serine 4 3.637e-25 0.31
ENL_HUMAN MLLT1 Protein ENL 2.158e-24 0.30
CPT1A_RAT Cpt1a Carnitine O-palmitoyltransferase 1, liver isoform 6.657e-23 0.33
MBTD1_HUMAN MBTD1 MBT domain-containing protein 1 1.434e-22 0.30
CPT1A_HUMAN CPT1A Carnitine O-palmitoyltransferase 1, liver isoform 1.488e-22 0.33
GPBAR_HUMAN GPBAR1 G-protein coupled bile acid receptor 1 7.146e-22 0.34
SPTC2_HUMAN SPTLC2 Serine palmitoyltransferase 2 1.126e-21 0.35
O70424_RAT Neuropeptide Y-Y2 receptor 1.974e-21 0.34
PD2R_MOUSE Ptgdr Prostaglandin D2 receptor 2.905e-21 0.34
CNR2_MOUSE Cnr2 Cannabinoid receptor 2 8.2e-21 0.33
SCNAA_RAT Scn10a Sodium channel protein type 10 subunit alpha 3.996e-20 0.38
GRIK1_HUMAN GRIK1 Glutamate receptor ionotropic, kainate 1 1.075e-19 0.32
LMBL1_HUMAN L3MBTL1 Lethal(3)malignant brain tumor-like protein 1 2.711e-19 0.31
RXFP2_HUMAN RXFP2 Relaxin receptor 2 8.07e-19 0.30
CNR1_MOUSE Cnr1 Cannabinoid receptor 1 2.325e-18 0.33
ENV_HV1Y2 env Envelope glycoprotein gp160 3.558e-18 0.32
EED_HUMAN EED Polycomb protein EED 5.078e-18 0.34
TAAR1_RAT Taar1 Trace amine-associated receptor 1 7.84e-18 0.36
GPBAR_MOUSE Gpbar1 G-protein coupled bile acid receptor 1 1.02e-17 0.34
KCNJ6_HUMAN KCNJ6 G protein-activated inward rectifier potassium channel 2 1.338e-17 0.30
FA10_HUMAN F10 Coagulation factor X 1.11e-16 0.40
Q38C41_TRYB2 Phosphotransferase 3.331e-16 0.31
LMBL3_HUMAN L3MBTL3 Lethal(3)malignant brain tumor-like protein 3 6.661e-16 0.31
KCNJ5_HUMAN KCNJ5 G protein-activated inward rectifier potassium channel 4 4.108e-15 0.30
Q8VBU5_MOUSE Pde4b Phosphodiesterase 9.326e-15 0.32
5HT1F_HUMAN HTR1F 5-hydroxytryptamine receptor 1F 9.992e-15 0.33
MALT1_HUMAN MALT1 Mucosa-associated lymphoid tissue lymphoma translocation protein 1 1.388e-14 0.31
RHOA_HUMAN RHOA Transforming protein RhoA 1.632e-14 0.32
DRD1_HUMAN DRD1 D(1A) dopamine receptor 1.821e-14 0.38
NR2E3_HUMAN NR2E3 Photoreceptor-specific nuclear receptor 1.965e-14 0.36
DCNL1_HUMAN DCUN1D1 DCN1-like protein 1 1.976e-14 0.30
KCNJ3_HUMAN KCNJ3 G protein-activated inward rectifier potassium channel 1 4.73e-14 0.30
TP53B_HUMAN TP53BP1 TP53-binding protein 1 6.173e-14 0.30
SHH_MOUSE Shh Sonic hedgehog protein 1.76e-13 0.31
RNT1_ASPOR rntA Guanyl-specific ribonuclease T1 5.476e-13 0.28
TAAR1_MOUSE Taar1 Trace amine-associated receptor 1 5.715e-13 0.36
S6A12_HUMAN SLC6A12 Sodium- and chloride-dependent betaine transporter 1.064e-12 0.31
PRIO_SHEEP PRNP Major prion protein 1.579e-12 0.32
H9CNL0_SPOEX Ryanodien receptor 7.204e-12 0.32
CCR1_HUMAN CCR1 C-C chemokine receptor type 1 8.897e-12 0.37
MCHR1_RAT Mchr1 Melanin-concentrating hormone receptor 1 1.041e-11 0.30
PAI1_HUMAN SERPINE1 Plasminogen activator inhibitor 1 7.971e-11 0.32
Q03732_HBV HBcAg Capsid protein 9.321e-11 0.31
PYGL_HUMAN PYGL Glycogen phosphorylase, liver form 1.194e-10 0.37
O77823_PIG PDE4A Cyclic AMP-specific phosphodiesterase SSPDE4A1A 1.484e-10 0.33
TRPC6_HUMAN TRPC6 Short transient receptor potential channel 6 3.578e-10 0.30
SC6A1_RAT Slc6a1 Sodium- and chloride-dependent GABA transporter 1 1.039e-09 0.31
ENPP3_HUMAN ENPP3 Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 2.304e-09 0.29
SC6A1_HUMAN SLC6A1 Sodium- and chloride-dependent GABA transporter 1 2.946e-09 0.30
TRPC3_HUMAN TRPC3 Short transient receptor potential channel 3 3.236e-09 0.30
CNR1_HUMAN CNR1 Cannabinoid receptor 1 3.787e-09 0.36
DHI1_HUMAN HSD11B1 Corticosteroid 11-beta-dehydrogenase isozyme 1 3.833e-09 0.44
IRAK4_HUMAN IRAK4 Interleukin-1 receptor-associated kinase 4 5.958e-09 0.35
OX1R_RAT Hcrtr1 Orexin receptor type 1 1.182e-08 0.32
BACE2_MOUSE Bace2 Beta-secretase 2 1.322e-08 0.29
IRAK1_HUMAN IRAK1 Interleukin-1 receptor-associated kinase 1 1.446e-08 0.33
Q5A7N4_CANAL TPT1 tRNA 2'-phosphotransferase 1.634e-08 0.28
PTGES_HUMAN PTGES Prostaglandin E synthase 1.729e-08 0.35
NR1H4_HUMAN NR1H4 Bile acid receptor 2.109e-08 0.38
A1Z199_HUMAN BCR/ABL fusion BCR/ABL p210 fusion protein 2.324e-08 0.29
ECR_BOMMO EcR Ecdysone receptor 2.797e-08 0.40
FSHR_HUMAN FSHR Follicle-stimulating hormone receptor 3.492e-08 0.33
OXYR_HUMAN OXTR Oxytocin receptor 3.607e-08 0.54
LIPL_RAT Lpl Lipoprotein lipase 1.266e-07 0.28
PPIA_RAT Ppia Peptidyl-prolyl cis-trans isomerase A 1.508e-07 0.32
KIT_HUMAN KIT Mast/stem cell growth factor receptor Kit 1.559e-07 0.33
SCNAA_MOUSE Scn10a Sodium channel protein type 10 subunit alpha 1.86e-07 0.32
ACPS_BACSU acpS Holo-[acyl-carrier-protein] synthase 2.22e-07 0.30
SCAF_HCMVA UL80 Capsid scaffolding protein 2.234e-07 0.31
BRPF1_HUMAN BRPF1 Peregrin 2.571e-07 0.37
SORT_HUMAN SORT1 Sortilin 2.999e-07 0.31
LDLR_HUMAN LDLR Low-density lipoprotein receptor 3.409e-07 0.33
TSHR_HUMAN TSHR Thyrotropin receptor 5.547e-07 0.29
FABH_ENTFA fabH 3-oxoacyl-[acyl-carrier-protein] synthase 3 5.67e-07 0.28
SMO_HUMAN SMO Smoothened homolog 6.221e-07 0.31
RL19A_YEAST RPL19A 60S ribosomal protein L19-A 6.28e-07 0.36
KCMA1_HUMAN KCNMA1 Calcium-activated potassium channel subunit alpha-1 6.804e-07 0.31
CYAA_BACAN cya Calmodulin-sensitive adenylate cyclase 7.696e-07 0.32
KCNK3_HUMAN KCNK3 Potassium channel subfamily K member 3 8.377e-07 0.38
CNR1_RAT Cnr1 Cannabinoid receptor 1 1.06e-06 0.31
DHB3_HUMAN HSD17B3 Testosterone 17-beta-dehydrogenase 3 1.19e-06 0.31
PGFRA_MOUSE Pdgfra Platelet-derived growth factor receptor alpha 1.217e-06 0.30
TYTR_TRYBB TPR Trypanothione reductase 1.288e-06 0.29
ACM1_HUMAN CHRM1 Muscarinic acetylcholine receptor M1 1.567e-06 0.39
GRM5_HUMAN GRM5 Metabotropic glutamate receptor 5 1.74e-06 0.33
ACM5_RAT Chrm5 Muscarinic acetylcholine receptor M5 1.894e-06 0.29
CML1_HUMAN CMKLR1 Chemokine-like receptor 1 2.59e-06 0.30
PTN13_HUMAN PTPN13 Tyrosine-protein phosphatase non-receptor type 13 2.849e-06 0.29
MK14_HUMAN MAPK14 Mitogen-activated protein kinase 14 4.251e-06 0.35
GASR_CANLF CCKBR Gastrin/cholecystokinin type B receptor 4.305e-06 0.29
SMO_MOUSE Smo Smoothened homolog 5.011e-06 0.30
CCNC_HUMAN CCNC Cyclin-C 5.679e-06 0.30
PB1_HUMAN PBRM1 Protein polybromo-1 5.752e-06 0.28
PDE7A_HUMAN PDE7A High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A 6.086e-06 0.32
FA11_HUMAN F11 Coagulation factor XI 8.666e-06 0.30

Prucalopride

5HT4R_HUMAN HTR4 5-hydroxytryptamine receptor 4 4.915e-152 1.00
5HT4R_RAT Htr4 5-hydroxytryptamine receptor 4 1.292e-149 1.00
5HT3A_HUMAN HTR3A 5-hydroxytryptamine receptor 3A 6.763e-08 1.00
5HT4R_CAVPO HTR4 5-hydroxytryptamine receptor 4 5.832e-99 0.49
DRD3_HUMAN DRD3 D(3) dopamine receptor 1.103e-45 0.47
UR2R_MACMU UTS2R Urotensin-2 receptor 1.605e-44 0.35
Q6Q253_PIG 5-HT4R 5-hydroxytryptamine receptor 4 protein 2.769e-44 0.47
5HT2A_HUMAN HTR2A 5-hydroxytryptamine receptor 2A 2.075e-42 0.47
UR2R_HUMAN UTS2R Urotensin-2 receptor 7.464e-42 0.36
S29A2_RAT Slc29a2 Equilibrative nucleoside transporter 2 1.181e-40 0.32
DRD3_RAT Drd3 D(3) dopamine receptor 6.071e-40 0.42
DRD2_HUMAN DRD2 D(2) dopamine receptor 2.774e-39 0.47
DRD4_HUMAN DRD4 D(4) dopamine receptor 3.078e-31 0.44
MCHR1_HUMAN MCHR1 Melanin-concentrating hormone receptor 1 1.727e-27 0.40
CRFR2_HUMAN CRHR2 Corticotropin-releasing factor receptor 2 9.139e-27 0.30
DRD1_BOVIN DRD1 D(1A) dopamine receptor 2.601e-26 0.44
DRD2_RAT Drd2 D(2) dopamine receptor 6.299e-24 0.63
SMYD3_HUMAN SMYD3 Histone-lysine N-methyltransferase SMYD3 1.402e-22 0.33
5HT3B_RAT Htr3b 5-hydroxytryptamine receptor 3B 5.72e-20 0.45
SSR5_HUMAN SSTR5 Somatostatin receptor type 5 4.556e-19 0.34
5HT3A_RAT Htr3a 5-hydroxytryptamine receptor 3A 1.382e-18 0.45
SC6A5_HUMAN SLC6A5 Sodium- and chloride-dependent glycine transporter 2 6.159e-18 0.34
MCHR1_MOUSE Mchr1 Melanin-concentrating hormone receptor 1 1.11e-16 0.31
RENI_CALJA REN Renin 2.665e-15 0.31
HRH3_RAT Hrh3 Histamine H3 receptor 4.441e-15 0.38
S6A12_HUMAN SLC6A12 Sodium- and chloride-dependent betaine transporter 8.105e-15 0.37
LYAM3_HUMAN SELP P-selectin 9.326e-15 0.33
HRH2_HUMAN HRH2 Histamine H2 receptor 3.242e-14 0.36
HPGDS_HUMAN HPGDS Hematopoietic prostaglandin D synthase 8.308e-13 0.31
SMYD2_HUMAN SMYD2 N-lysine methyltransferase SMYD2 1.468e-12 0.31
DCNL1_HUMAN DCUN1D1 DCN1-like protein 1 3.772e-12 0.32
CAC1I_HUMAN CACNA1I Voltage-dependent T-type calcium channel subunit alpha-1I 1.419e-11 0.32
SGMR1_HUMAN SIGMAR1 Sigma non-opioid intracellular receptor 1 2.437e-11 0.38
DRD4_RAT Drd4 D(4) dopamine receptor 3.255e-11 0.42
5HT1E_HUMAN HTR1E 5-hydroxytryptamine receptor 1E 6.842e-11 0.47
MCHR1_RAT Mchr1 Melanin-concentrating hormone receptor 1 4.016e-10 0.33
PDE6A_BOVIN PDE6A Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha 9.063e-10 0.29
ANM6_HUMAN PRMT6 Protein arginine N-methyltransferase 6 1.31e-09 0.38
5HT2A_RAT Htr2a 5-hydroxytryptamine receptor 2A 1.729e-09 0.38
AGTR1_PIG AGTR1 Type-1 angiotensin II receptor 2.353e-09 0.29
CRFR1_HUMAN CRHR1 Corticotropin-releasing factor receptor 1 6.339e-09 0.32
MTR1B_HUMAN MTNR1B Melatonin receptor type 1B 7.144e-09 0.31
CCR3_HUMAN CCR3 C-C chemokine receptor type 3 8.138e-09 0.33
HRH3_HUMAN HRH3 Histamine H3 receptor 9.51e-09 0.39
DRD1_MOUSE Drd1 D(1A) dopamine receptor 1.098e-08 0.47
5HT7R_HUMAN HTR7 5-hydroxytryptamine receptor 7 1.457e-08 0.42
IGF1R_HUMAN IGF1R Insulin-like growth factor 1 receptor 1.5e-08 0.36
MTR1A_HUMAN MTNR1A Melatonin receptor type 1A 3.783e-08 0.31
CARM1_HUMAN CARM1 Histone-arginine methyltransferase CARM1 4.931e-08 0.38
ACM1_HUMAN CHRM1 Muscarinic acetylcholine receptor M1 8.195e-08 0.42
5HT1A_MOUSE Htr1a 5-hydroxytryptamine receptor 1A 1.172e-07 0.47
KCNH2_HUMAN KCNH2 Potassium voltage-gated channel subfamily H member 2 3.481e-07 0.44
S29A1_HUMAN SLC29A1 Equilibrative nucleoside transporter 1 3.559e-07 0.32
FA10_BOVIN F10 Coagulation factor X 5.467e-07 0.37
FAK1_HUMAN PTK2 Focal adhesion kinase 1 7.199e-07 0.31
5HT1A_RAT Htr1a 5-hydroxytryptamine receptor 1A 1.047e-06 0.39
TS1R1_HUMAN TAS1R1 Taste receptor type 1 member 1 3.91e-06 0.29
5HT1A_HUMAN HTR1A 5-hydroxytryptamine receptor 1A 3.944e-06 0.42
PDE9A_RAT Pde9a High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A 5.595e-06 0.32
PDK1_HUMAN PDK1 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial 6.914e-06 0.34
ADA2B_HUMAN ADRA2B Alpha-2B adrenergic receptor 7.869e-06 0.42
CAC1H_HUMAN CACNA1H Voltage-dependent T-type calcium channel subunit alpha-1H 8.132e-06 0.36
PLD1_RAT Pld1 Phospholipase D1 8.176e-06 0.28
TYRO3_HUMAN TYRO3 Tyrosine-protein kinase receptor TYRO3 8.843e-06 0.33

Bazedoxifene

ESR1_HUMAN ESR1 Estrogen receptor 7.373e-148 1.00
ESR2_HUMAN ESR2 Estrogen receptor beta 3.804e-120 1.00
HRH3_HUMAN HRH3 Histamine H3 receptor 2.097e-108 0.51
NORA_STAAU norA Quinolone resistance protein NorA 8.725e-98 0.49
LKHA4_HUMAN LTA4H Leukotriene A-4 hydrolase 7.383e-80 0.43
FABI_STAAR fabI Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI 5.55e-55 0.34
PSB1_HUMAN PSMB1 Proteasome subunit beta type-1 4.288e-53 0.46
HRH3_MOUSE Hrh3 Histamine H3 receptor 4.073e-43 0.39
HRH3_RAT Hrh3 Histamine H3 receptor 5.435e-42 0.45
ESR1_RAT Esr1 Estrogen receptor 1.548e-39 0.53
HNMT_RAT Hnmt Histamine N-methyltransferase 1.072e-36 0.33
PSB2_HUMAN PSMB2 Proteasome subunit beta type-2 3.965e-34 0.46
HRH2_CAVPO HRH2 Histamine H2 receptor 4.42e-33 0.38
ESR2_RAT Esr2 Estrogen receptor beta 3.375e-32 0.53
CHLE_HORSE BCHE Cholinesterase 3.691e-32 0.41
ACES_ELEEL ache Acetylcholinesterase 4.121e-31 0.41
PA2GA_HUMAN PLA2G2A Phospholipase A2, membrane associated 1.139e-30 0.36
BMP4_HUMAN BMP4 Bone morphogenetic protein 4 1.394e-28 0.34
FABI_ECOLI fabI Enoyl-[acyl-carrier-protein] reductase [NADH] FabI 3.138e-28 0.33
HRH1_HUMAN HRH1 Histamine H1 receptor 2.596e-27 0.34
Q6A2E2_AEDAE ace-1 Acetylcholinesterase 1.239e-26 0.33
V1BR_HUMAN AVPR1B Vasopressin V1b receptor 4.046e-26 0.32
PPBT_BOVIN ALPL Alkaline phosphatase, tissue-nonspecific isozyme 3.871e-23 0.34
PSB5_HUMAN PSMB5 Proteasome subunit beta type-5 2.505e-22 0.46
HRH3_CAVPO HRH3 Histamine H3 receptor 3.578e-22 0.39
SCRB1_HUMAN SCARB1 Scavenger receptor class B member 1 3.168e-20 0.34
5HT5A_MOUSE Htr5a 5-hydroxytryptamine receptor 5A 8.763e-19 0.35
PPARG_HUMAN PPARG Peroxisome proliferator-activated receptor gamma 9.483e-19 0.35
YES_HUMAN YES1 Tyrosine-protein kinase Yes 1.929e-18 0.40
PGH2_RAT Ptgs2 Prostaglandin G/H synthase 2 5.113e-17 0.30
CHKA_HUMAN CHKA Choline kinase alpha 1.11e-16 0.33
ACES_MOUSE Ache Acetylcholinesterase 2.22e-16 0.31
HRH1_CAVPO HRH1 Histamine H1 receptor 5.551e-16 0.38
RAGE_HUMAN AGER Advanced glycosylation end product-specific receptor 1.332e-15 0.36
PGES2_HUMAN PTGES2 Prostaglandin E synthase 2 1.443e-15 0.32
SRC_HUMAN SRC Proto-oncogene tyrosine-protein kinase Src 2.52e-14 0.40
PPBI_BOVIN ALPI Intestinal-type alkaline phosphatase 2.764e-14 0.34
NMD3A_RAT Grin3a Glutamate receptor ionotropic, NMDA 3A 2.269e-13 0.40
SGMR1_CAVPO SIGMAR1 Sigma non-opioid intracellular receptor 1 3.587e-13 0.38
SNRK_HUMAN SNRK SNF-related serine/threonine-protein kinase 4.607e-13 0.28
HRH2_HUMAN HRH2 Histamine H2 receptor 5.569e-13 0.33
KCNH2_HUMAN KCNH2 Potassium voltage-gated channel subfamily H member 2 9.739e-13 0.44
ACES_RAT Ache Acetylcholinesterase 6.916e-12 0.34
MCHR1_HUMAN MCHR1 Melanin-concentrating hormone receptor 1 1.211e-11 0.39
CBP_HUMAN CREBBP CREB-binding protein 1.338e-11 0.33
NPY1R_HUMAN NPY1R Neuropeptide Y receptor type 1 5.037e-11 0.37
NEK3_HUMAN NEK3 Serine/threonine-protein kinase Nek3 1.257e-10 0.28
S1PR5_HUMAN S1PR5 Sphingosine 1-phosphate receptor 5 1.831e-10 0.33
ACK1_MOUSE Tnk2 Activated CDC42 kinase 1 2.204e-10 0.30
5HT3A_RAT Htr3a 5-hydroxytryptamine receptor 3A 2.548e-10 0.38
BMPR2_HUMAN BMPR2 Bone morphogenetic protein receptor type-2 4.587e-10 0.34
Q8JXU8_9HEPC NS5B RNA-directed RNA polymerase 8.034e-10 0.33
NEK11_HUMAN NEK11 Serine/threonine-protein kinase Nek11 8.49e-10 0.28
DRD5_HUMAN DRD5 D(1B) dopamine receptor 1.906e-09 0.33
V1BR_RAT Avpr1b Vasopressin V1b receptor 2.218e-09 0.32
5HT2B_HUMAN HTR2B 5-hydroxytryptamine receptor 2B 3.19e-09 0.33
EBP_CAVPO EBP 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase 3.697e-09 0.34
STK38_HUMAN STK38 Serine/threonine-protein kinase 38 4.015e-09 0.28
TBK1_HUMAN TBK1 Serine/threonine-protein kinase TBK1 4.177e-09 0.37
PDE6D_HUMAN PDE6D Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta 6.269e-09 0.36
ACES_HUMAN ACHE Acetylcholinesterase 6.442e-09 0.45
WEE1_HUMAN WEE1 Wee1-like protein kinase 1.181e-08 0.30
VGFR2_HUMAN KDR Vascular endothelial growth factor receptor 2 1.205e-08 0.44
CHK1_HUMAN CHEK1 Serine/threonine-protein kinase Chk1 1.394e-08 0.37
MK06_HUMAN MAPK6 Mitogen-activated protein kinase 6 1.464e-08 0.28
5HT1B_HUMAN HTR1B 5-hydroxytryptamine receptor 1B 1.98e-08 0.36
VGFR3_HUMAN FLT4 Vascular endothelial growth factor receptor 3 2.714e-08 0.36
5HT5A_HUMAN HTR5A 5-hydroxytryptamine receptor 5A 2.756e-08 0.32
5HT3A_HUMAN HTR3A 5-hydroxytryptamine receptor 3A 3.245e-08 0.38
KCNA5_HUMAN KCNA5 Potassium voltage-gated channel subfamily A member 5 3.423e-08 0.35
AL5AP_HUMAN ALOX5AP Arachidonate 5-lipoxygenase-activating protein 3.807e-08 0.35
GRIK2_HUMAN GRIK2 Glutamate receptor ionotropic, kainate 2 4.107e-08 0.39
Q63380_RAT NET Transporter 4.18e-08 0.36
NEK9_HUMAN NEK9 Serine/threonine-protein kinase Nek9 4.387e-08 0.28
TLK2_HUMAN TLK2 Serine/threonine-protein kinase tousled-like 2 4.387e-08 0.28
ACK1_HUMAN TNK2 Activated CDC42 kinase 1 6.511e-08 0.31
PDK1_HUMAN PDK1 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial 7.076e-08 0.42
5HT1D_HUMAN HTR1D 5-hydroxytryptamine receptor 1D 8.418e-08 0.36
BMR1B_HUMAN BMPR1B Bone morphogenetic protein receptor type-1B 8.809e-08 0.34
SGMR1_RAT Sigmar1 Sigma non-opioid intracellular receptor 1 1.094e-07 0.30
AAKB1_HUMAN PRKAB1 5'-AMP-activated protein kinase subunit beta-1 1.119e-07 0.34
CDKL5_HUMAN CDKL5 Cyclin-dependent kinase-like 5 1.129e-07 0.28
COQ8A_HUMAN COQ8A Atypical kinase COQ8A, mitochondrial 1.129e-07 0.28
CSKP_HUMAN CASK Peripheral plasma membrane protein CASK 1.129e-07 0.28
STK39_HUMAN STK39 STE20/SPS1-related proline-alanine-rich protein kinase 1.129e-07 0.28
NMDE2_RAT Grin2b Glutamate receptor ionotropic, NMDA 2B 1.189e-07 0.48
CDK16_HUMAN CDK16 Cyclin-dependent kinase 16 1.31e-07 0.30
PGFRA_MOUSE Pdgfra Platelet-derived growth factor receptor alpha 1.717e-07 0.35
DCLK2_HUMAN DCLK2 Serine/threonine-protein kinase DCLK2 2.575e-07 0.28
AOFB_HUMAN MAOB Amine oxidase [flavin-containing] B 2.672e-07 0.41
LYAG_MOUSE Gaa Lysosomal alpha-glucosidase 2.925e-07 0.28
Q865E1_MACMU HRH3 Histamine receptor H3 3.105e-07 0.39
SGMR1_HUMAN SIGMAR1 Sigma non-opioid intracellular receptor 1 3.16e-07 0.35
CAC1G_HUMAN CACNA1G Voltage-dependent T-type calcium channel subunit alpha-1G 3.306e-07 0.34
COQ8B_HUMAN COQ8B Atypical kinase COQ8B, mitochondrial 5.325e-07 0.28
NEK5_HUMAN NEK5 Serine/threonine-protein kinase Nek5 5.325e-07 0.28
NEK7_HUMAN NEK7 Serine/threonine-protein kinase Nek7 5.325e-07 0.28
SBK3_HUMAN SBK3 Uncharacterized serine/threonine-protein kinase SBK3 5.325e-07 0.28
SIK3_HUMAN SIK3 Serine/threonine-protein kinase SIK3 5.325e-07 0.28
SRPK2_HUMAN SRPK2 SRSF protein kinase 2 5.325e-07 0.28
STK11_HUMAN STK11 Serine/threonine-protein kinase STK11 5.325e-07 0.28
TLK1_HUMAN TLK1 Serine/threonine-protein kinase tousled-like 1 5.325e-07 0.28
ABL1_MOUSE Abl1 Tyrosine-protein kinase ABL1 7.227e-07 0.29
ADA1A_HUMAN ADRA1A Alpha-1A adrenergic receptor 7.283e-07 0.44
LKHA4_MOUSE Lta4h Leukotriene A-4 hydrolase 9.777e-07 0.35
HSF1_HUMAN HSF1 Heat shock factor protein 1 9.801e-07 0.31
NIM1_HUMAN NIM1K Serine/threonine-protein kinase NIM1 1.016e-06 0.28
PRP4B_HUMAN PRPF4B Serine/threonine-protein kinase PRP4 homolog 1.016e-06 0.28
WEE2_HUMAN WEE2 Wee1-like protein kinase 2 1.016e-06 0.28
SC6A4_RAT Slc6a4 Sodium-dependent serotonin transporter 1.234e-06 0.36
HMOX2_RAT Hmox2 Heme oxygenase 2 1.661e-06 0.33
CDK15_HUMAN CDK15 Cyclin-dependent kinase 15 1.815e-06 0.28
SGK3_HUMAN SGK3 Serine/threonine-protein kinase Sgk3 1.815e-06 0.28
BMR1A_HUMAN BMPR1A Bone morphogenetic protein receptor type-1A 2.029e-06 0.34
5HT2A_HUMAN HTR2A 5-hydroxytryptamine receptor 2A 2.282e-06 0.36
5HT2C_HUMAN HTR2C 5-hydroxytryptamine receptor 2C 2.752e-06 0.33
KS6A1_HUMAN RPS6KA1 Ribosomal protein S6 kinase alpha-1 2.774e-06 0.34
CDK18_HUMAN CDK18 Cyclin-dependent kinase 18 3.063e-06 0.28
KCC1G_HUMAN CAMK1G Calcium/calmodulin-dependent protein kinase type 1G 3.063e-06 0.28
SBK1_HUMAN SBK1 Serine/threonine-protein kinase SBK1 3.063e-06 0.28
PGFRB_HUMAN PDGFRB Platelet-derived growth factor receptor beta 3.958e-06 0.40
FLT3_HUMAN FLT3 Receptor-type tyrosine-protein kinase FLT3 4.006e-06 0.38
NEK6_HUMAN NEK6 Serine/threonine-protein kinase Nek6 4.928e-06 0.28
PAK6_HUMAN PAK6 Serine/threonine-protein kinase PAK 6 4.928e-06 0.28
RIPK4_HUMAN RIPK4 Receptor-interacting serine/threonine-protein kinase 4 4.928e-06 0.28
SKN1_CAEEL skn-1 Protein skinhead-1 5.82e-06 0.33
CILK1_HUMAN CILK1 Serine/threonine-protein kinase ICK 7.607e-06 0.28
INSRR_HUMAN INSRR Insulin receptor-related protein 7.607e-06 0.28
M3K4_HUMAN MAP3K4 Mitogen-activated protein kinase kinase kinase 4 7.607e-06 0.28
MYLK3_HUMAN MYLK3 Myosin light chain kinase 3 7.607e-06 0.28
MYLK4_HUMAN MYLK4 Myosin light chain kinase family member 4 7.607e-06 0.28
MET_HUMAN MET Hepatocyte growth factor receptor 7.978e-06 0.34
TLR9_HUMAN TLR9 Toll-like receptor 9 8.103e-06 0.34

Avanafil

PDE5A_CANLF PDE5A cGMP-specific 3',5'-cyclic phosphodiesterase 7.04e-143 1.00
PDE5A_HUMAN PDE5A cGMP-specific 3',5'-cyclic phosphodiesterase 7.702e-59 1.00
PDE6A_BOVIN PDE6A Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha 6.763e-95 0.59
TF7L2_HUMAN TCF7L2 Transcription factor 7-like 2 1.895e-54 0.39
CTNB1_HUMAN CTNNB1 Catenin beta-1 3.262e-50 0.39
CCR4_MOUSE Ccr4 C-C chemokine receptor type 4 2.981e-47 0.39
PDE5A_BOVIN PDE5A cGMP-specific 3',5'-cyclic phosphodiesterase 5.792e-46 0.41
DRD2_CANLF DRD2 D(2) dopamine receptor 6.005e-43 0.34
ST1E1_MOUSE Sult1e1 Sulfotransferase 1E1 9.362e-36 0.28
NLRP3_MOUSE Nlrp3 NACHT, LRR and PYD domains-containing protein 3 4.115e-34 0.34
O77823_PIG PDE4A Cyclic AMP-specific phosphodiesterase SSPDE4A1A 1.17e-28 0.38
SC5A7_HUMAN SLC5A7 High affinity choline transporter 1 3.424e-26 0.30
GHSR_RAT Ghsr Growth hormone secretagogue receptor type 1 2.021e-23 0.41
TYRO3_HUMAN TYRO3 Tyrosine-protein kinase receptor TYRO3 1.263e-22 0.36
EPHA2_HUMAN EPHA2 Ephrin type-A receptor 2 1.564e-20 0.32
DRD2_RAT Drd2 D(2) dopamine receptor 6.482e-20 0.36
STAT6_HUMAN STAT6 Signal transducer and activator of transcription 6 4.935e-19 0.34
DPOL_HCMVA UL54 DNA polymerase catalytic subunit 1.458e-18 0.36
EPHB4_HUMAN EPHB4 Ephrin type-B receptor 4 1.832e-18 0.32
LYAM3_HUMAN SELP P-selectin 2.613e-18 0.36
ROCK1_HUMAN ROCK1 Rho-associated protein kinase 1 3.445e-17 0.36
EHMT2_HUMAN EHMT2 Histone-lysine N-methyltransferase EHMT2 4.5e-17 0.33
ALK_HUMAN ALK ALK tyrosine kinase receptor 1.11e-16 0.33
CCR4_HUMAN CCR4 C-C chemokine receptor type 4 2.22e-16 0.39
MELK_HUMAN MELK Maternal embryonic leucine zipper kinase 2.22e-16 0.36
DLDH_MYCTU lpdC Dihydrolipoyl dehydrogenase 1.443e-15 0.34
SPHK1_MOUSE Sphk1 Sphingosine kinase 1 1.554e-15 0.29
OX2R_HUMAN HCRTR2 Orexin receptor type 2 2.109e-15 0.39
CDK1_HUMAN CDK1 Cyclin-dependent kinase 1 3.553e-15 0.50
ABCC8_HUMAN ABCC8 ATP-binding cassette sub-family C member 8 6.106e-15 0.34
DRD1_BOVIN DRD1 D(1A) dopamine receptor 7.327e-15 0.32
PDE6C_HUMAN PDE6C Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 1.377e-14 0.35
PDE11_HUMAN PDE11A Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A 1.61e-14 0.37
OX1R_HUMAN HCRTR1 Orexin receptor type 1 2.165e-14 0.39
5HT4R_HUMAN HTR4 5-hydroxytryptamine receptor 4 5.229e-14 0.34
ABCBB_RAT Abcb11 Bile salt export pump 7.838e-14 0.34
PI4KB_HUMAN PI4KB Phosphatidylinositol 4-kinase beta 9.359e-14 0.36
PP1A_HUMAN PPP1CA Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 9.626e-14 0.34
LRRK2_HUMAN LRRK2 Leucine-rich repeat serine/threonine-protein kinase 2 2.652e-13 0.34
FAK1_HUMAN PTK2 Focal adhesion kinase 1 4.114e-13 0.35
ROCK2_HUMAN ROCK2 Rho-associated protein kinase 2 6.717e-13 0.36
NU1M_BOVIN MT-ND1 NADH-ubiquinone oxidoreductase chain 1 6.77e-13 0.31
EZRI_HUMAN EZR Ezrin 7.615e-13 0.31
TERA_HUMAN VCP Transitional endoplasmic reticulum ATPase 1.553e-12 0.32
PGK1_HUMAN PGK1 Phosphoglycerate kinase 1 2.186e-12 0.33
ADA1A_RABIT ADRA1A Alpha-1A adrenergic receptor 4.063e-12 0.31
ITB7_HUMAN ITGB7 Integrin beta-7 6.181e-12 0.33
ZAP70_HUMAN ZAP70 Tyrosine-protein kinase ZAP-70 9.316e-12 0.33
NOS2_HUMAN NOS2 Nitric oxide synthase, inducible 9.901e-12 0.38
SPHK2_HUMAN SPHK2 Sphingosine kinase 2 1.075e-11 0.31
DRTS_TRYCR Bifunctional dihydrofolate reductase-thymidylate synthase 1.107e-11 0.28
ACOD_HUMAN SCD Acyl-CoA desaturase 1.837e-11 0.31
DRD4_HUMAN DRD4 D(4) dopamine receptor 2.624e-11 0.34
TRPA1_RAT Trpa1 Transient receptor potential cation channel subfamily A member 1 3.168e-11 0.37
PPIB_HUMAN PPIB Peptidyl-prolyl cis-trans isomerase B 3.845e-11 0.30
DRD3_RAT Drd3 D(3) dopamine receptor 5.725e-11 0.32
UBC9_HUMAN UBE2I SUMO-conjugating enzyme UBC9 1.168e-10 0.30
ERBB2_HUMAN ERBB2 Receptor tyrosine-protein kinase erbB-2 1.221e-10 0.33
F1SH20_PIG TRHDE Uncharacterized protein 1.245e-10 0.28
EGFR_HUMAN EGFR Epidermal growth factor receptor 1.331e-10 0.33
PTGES_CANLF PTGES Prostaglandin E synthase 1.621e-10 0.28
PDPK1_HUMAN PDPK1 3-phosphoinositide-dependent protein kinase 1 3.217e-10 0.33
SEPR_MOUSE Fap Prolyl endopeptidase FAP 3.316e-10 0.30
S15A2_RAT Slc15a2 Solute carrier family 15 member 2 4.192e-10 0.34
NTRK1_HUMAN NTRK1 High affinity nerve growth factor receptor 8.773e-10 0.32
DPOL_HHV6U U38 DNA polymerase catalytic subunit 1.852e-09 0.34
SPHK1_HUMAN SPHK1 Sphingosine kinase 1 2.088e-09 0.31
DRD2_HUMAN DRD2 D(2) dopamine receptor 2.245e-09 0.37
S22A6_RAT Slc22a6 Solute carrier family 22 member 6 4.818e-09 0.34
SCN3A_HUMAN SCN3A Sodium channel protein type 3 subunit alpha 5.776e-09 0.32
DRD3_CHLAE DRD3 D(3) dopamine receptor 1.141e-08 0.31
CASR_HUMAN CASR Extracellular calcium-sensing receptor 1.251e-08 0.33
CSN5_HUMAN COPS5 COP9 signalosome complex subunit 5 1.791e-08 0.28
ACES_ANOGA Ace Acetylcholinesterase 2.421e-08 0.29
CCR3_HUMAN CCR3 C-C chemokine receptor type 3 3.235e-08 0.36
5HT4R_RAT Htr4 5-hydroxytryptamine receptor 4 3.802e-08 0.30
WNK1_HUMAN WNK1 Serine/threonine-protein kinase WNK1 4.33e-08 0.28
AA1R_MOUSE Adora1 Adenosine receptor A1 1.221e-07 0.29
GRK5_HUMAN GRK5 G protein-coupled receptor kinase 5 4.379e-07 0.30
MERTK_HUMAN MERTK Tyrosine-protein kinase Mer 7.451e-07 0.36
CXCR3_RAT Cxcr3 C-X-C chemokine receptor type 3 1.048e-06 0.30
SCN8A_HUMAN SCN8A Sodium channel protein type 8 subunit alpha 1.38e-06 0.29
ATS4_HUMAN ADAMTS4 A disintegrin and metalloproteinase with thrombospondin motifs 4 2.011e-06 0.30
G3PC_LEIME GAPC Glyceraldehyde-3-phosphate dehydrogenase, cytosolic 2.017e-06 0.28
MAT1_HUMAN MNAT1 CDK-activating kinase assembly factor MAT1 2.102e-06 0.30
PTPRG_HUMAN PTPRG Receptor-type tyrosine-protein phosphatase gamma 2.849e-06 0.29
IRAK4_HUMAN IRAK4 Interleukin-1 receptor-associated kinase 4 2.917e-06 0.35
CXCR3_HUMAN CXCR3 C-X-C chemokine receptor type 3 2.958e-06 0.34
TS1R1_HUMAN TAS1R1 Taste receptor type 1 member 1 3.025e-06 0.30
BRAF_HUMAN BRAF Serine/threonine-protein kinase B-raf 3.292e-06 0.41
CDK5_HUMAN CDK5 Cyclin-dependent-like kinase 5 5.047e-06 0.42
IGF1R_HUMAN IGF1R Insulin-like growth factor 1 receptor 6.017e-06 0.33
G3I1B6_CRIGR 5-hydroxytryptamine receptor 7.329e-06 0.29
MTCA2_MYCTU mtcA2 Carbonic anhydrase 2 7.777e-06 0.34
5HT1B_CRIGR HTR1B 5-hydroxytryptamine receptor 1B 8.53e-06 0.29

Migalastat

GANC_MOUSE Ganc Neutral alpha-glucosidase C 1.289e-124 1.00
AGALC_ASPNG aglC Alpha-galactosidase C 2.9e-124 1.00
GDE_HUMAN AGL Glycogen debranching enzyme 1.668e-106 1.00
GANAB_HUMAN GANAB Neutral alpha-glucosidase AB 1.663e-103 1.00
GDE_RABIT AGL Glycogen debranching enzyme 1.116e-98 1.00
LYAG_RAT Gaa Lysosomal alpha-glucosidase 1.895e-97 1.00
AGAL_HUMAN GLA Alpha-galactosidase A 2.687e-94 1.00
AGAL_COFAR Alpha-galactosidase 6.446e-84 1.00
Q9LGC6_ORYSJ P0504H10.9 Putative alpha-glucosidase 2.166e-81 1.00
Q43014_PRUAV Beta-glucosidase 2.714e-79 1.00
SUIS_RAT Si Sucrase-isomaltase, intestinal 1.91e-77 1.00
FUCO_BOVIN FUCA1 Tissue alpha-L-fucosidase 3.8e-71 1.00
KLRBA_RAT Klrb1a Killer cell lectin-like receptor subfamily B member 1A 9.894e-67 1.00
LYAG_BOVIN GAA Lysosomal alpha-glucosidase 1.089e-50 1.00
GLCM_HUMAN GBA Lysosomal acid glucosylceramidase 9.281e-48 1.00
FUCO_HUMAN FUCA1 Tissue alpha-L-fucosidase 3.51e-47 1.00
LYAG_HUMAN GAA Lysosomal alpha-glucosidase 7.838e-47 1.00
P94451_GEOSE Alpha-amylase 6.524e-44 1.00
MGA_HUMAN MGAM Maltase-glucoamylase, intestinal 1.057e-32 1.00
SUIS_HUMAN SI Sucrase-isomaltase, intestinal 7.13e-23 1.00
CEGT_HUMAN UGCG Ceramide glucosyltransferase 8.694e-06 1.00
MAL62_YEASX MAL62 Alpha-glucosidase MAL62 1.344e-105 0.86
LPH_RAT Lct Lactase-phlorizin hydrolase 3.741e-104 0.52
I3LIR5_PIG TREH Trehalase 4.762e-95 0.86
AMYG_YEAST SGA1 Glucoamylase, intracellular sporulation-specific 9.915e-87 0.86
D3ZUM4_RAT Glb1 Beta-galactosidase 4.856e-79 0.52
FUCO2_HUMAN FUCA2 Plasma alpha-L-fucosidase 8.237e-67 0.46
MA1B1_HUMAN MAN1B1 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase 1.284e-65 0.86
D3ZJF9_RAT Gla Alpha-galactosidase 1.955e-57 0.46
GANC_HUMAN GANC Neutral alpha-glucosidase C 1.955e-57 0.46
BGAL_BOVIN GLB1 Beta-galactosidase 6.316e-55 0.57
GBA3_HUMAN GBA3 Cytosolic beta-glucosidase 3.067e-54 0.43
Q9SEH8_SOYBN Man1 alpha-1,2-Mannosidase 3.819e-53 0.38
BGAL_ECOLI lacZ Beta-galactosidase 2.019e-52 0.86
BGAL_HUMAN GLB1 Beta-galactosidase 2.09e-51 0.57
MA2C1_RAT Man2c1 Alpha-mannosidase 2C1 5.54e-49 0.43
Q5DUH8_COFAR gal1 Alpha-galactosidase 9.43e-46 0.36
Q9GPQ4_TRYVI IAG-nucleoside hydrolase 1.443e-43 0.86
O70282_RAT Trehalase 4.283e-43 0.54
Q2U7N3_ASPOR Beta-galactosidase 2.984e-42 0.35
BGLS_CALSA bglA Beta-glucosidase A 3.256e-42 0.34
PYGL_RAT Pygl Glycogen phosphorylase, liver form 1.528e-41 0.86
NAGZ_PSEAE nagZ Beta-hexosaminidase 6.863e-39 0.48
AGLU_ORYSJ Probable alpha-glucosidase Os06g0675700 1.381e-38 0.31
BGAL_ASPNG lacA Beta-galactosidase 5.796e-35 0.43
GLCM_BOVIN GBA Lysosomal acid glucosylceramidase 4.79e-32 0.52
Q8AAK6_BACTN Beta-mannosidase 2.16e-26 0.38
BGAL_ECOLX lacZ Beta-galactosidase 1.936e-23 0.57
BGLS_RHIRD cbg-1 Beta-glucosidase 2.74e-19 0.43
B4EH87_BURCJ Lectin 5.03e-18 0.34
FUCO_RAT Fuca1 Tissue alpha-L-fucosidase 6.8e-18 0.46
MA2A1_HUMAN MAN2A1 Alpha-mannosidase 2 1.882e-17 0.33
GBA2_HUMAN GBA2 Non-lysosomal glucosylceramidase 1.221e-10 0.48
LYAG_MOUSE Gaa Lysosomal alpha-glucosidase 5.175e-08 0.31
PYGM_RABIT PYGM Glycogen phosphorylase, muscle form 4.067e-07 0.86

Etravirine

MRP3_HUMAN ABCC3 Canalicular multispecific organic anion transporter 2 2.9e-124 1.00
Q9WKE8_9HIV1 reverse transcriptase Reverse transcriptase 1.32e-85 1.00
Q9WJQ2_9HIV1 reverse transcriptase Reverse transcriptase protein 9.684e-38 1.00
MRP2_HUMAN ABCC2 Canalicular multispecific organic anion transporter 1 4.419e-25 1.00
CYSP_TRYCR Cruzipain 7.646e-07 1.00
ABCG2_HUMAN ABCG2 Broad substrate specificity ATP-binding cassette transporter ABCG2 3.985e-06 1.00
MRP1_HUMAN ABCC1 Multidrug resistance-associated protein 1 0.0005506 1.00
MDR1_HUMAN ABCB1 ATP-dependent translocase ABCB1 0.2687 1.00
STK39_RAT Stk39 STE20/SPS1-related proline-alanine-rich protein kinase 1.489e-31 0.31
RS27_HUMAN RPS27 40S ribosomal protein S27 1.841e-22 0.32
Q9HUN3_PSEAE dnaB Replicative DNA helicase 6.449e-13 0.28
PLCB_HUMAN AGPAT2 1-acyl-sn-glycerol-3-phosphate acyltransferase beta 9.1e-13 0.37
CCNA1_HUMAN CCNA1 Cyclin-A1 3.193e-11 0.35
JAK3_MOUSE Jak3 Tyrosine-protein kinase JAK3 6.177e-11 0.32
CCNA2_HUMAN CCNA2 Cyclin-A2 2.406e-07 0.35
KC1G2_HUMAN CSNK1G2 Casein kinase I isoform gamma-2 2.233e-06 0.33

Abiraterone

CP17A_HUMAN CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase 6.376e-119 1.00
CP17A_RAT Cyp17a1 Steroid 17-alpha-hydroxylase/17,20 lyase 3.924e-85 1.00
CP17A_MACFA CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase 2.714e-79 1.00
C11B1_HUMAN CYP11B1 Cytochrome P450 11B1, mitochondrial 0.001963 1.00
C11B2_HUMAN CYP11B2 Cytochrome P450 11B2, mitochondrial 0.01712 1.00
CP11A_BOVIN CYP11A1 Cholesterol side-chain cleavage enzyme, mitochondrial 1.225e-59 0.48
DHC24_HUMAN DHCR24 Delta(24)-sterol reductase 2.193e-55 0.48
Q9GRG7_9TRYP g6pd Glucose-6-phosphate 1-dehydrogenase 3.23e-42 0.53
SHBG_HUMAN SHBG Sex hormone-binding globulin 1.935e-35 0.56
CRYAB_HUMAN CRYAB Alpha-crystallin B chain 5.796e-35 0.43
DHCR7_RAT Dhcr7 7-dehydrocholesterol reductase 1.439e-34 0.45
CP125_MYCTU cyp125 Steroid C26-monooxygenase 1.78e-34 0.43
SMT1_ARATH SMT1 Cycloartenol-C-24-methyltransferase 3.065e-25 0.41
NPCL1_HUMAN NPC1L1 NPC1-like intracellular cholesterol transporter 1 2.527e-22 0.49
CBG_HUMAN SERPINA6 Corticosteroid-binding globulin 7.464e-21 0.53
ERG2_YEAST ERG2 C-8 sterol isomerase 2.541e-20 0.40
AK1C3_HUMAN AKR1C3 Aldo-keto reductase family 1 member C3 4.212e-20 0.42
FGF2_HUMAN FGF2 Fibroblast growth factor 2 7.159e-20 0.43
G6PD_HUMAN G6PD Glucose-6-phosphate 1-dehydrogenase 2.22e-16 0.53
NPC1_HUMAN NPC1 NPC intracellular cholesterol transporter 1 2.554e-15 0.29
ANDR_HUMAN AR Androgen receptor 2.709e-14 0.52
NR1H3_HUMAN NR1H3 Oxysterols receptor LXR-alpha 3.375e-14 0.49
ACHB3_MOUSE Chrnb3 Neuronal acetylcholine receptor subunit beta-3 8.116e-14 0.30
ESR2_HUMAN ESR2 Estrogen receptor beta 8.349e-14 0.42
SHH_HUMAN SHH Sonic hedgehog protein 4.604e-13 0.33
MRP4_HUMAN ABCC4 Multidrug resistance-associated protein 4 8.464e-13 0.38
S5A2_HUMAN SRD5A2 3-oxo-5-alpha-steroid 4-dehydrogenase 2 9.567e-13 0.53
EBP_HUMAN EBP 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase 1.716e-11 0.41
ACHA6_MOUSE Chrna6 Neuronal acetylcholine receptor subunit alpha-6 3.122e-11 0.30
CP19A_HUMAN CYP19A1 Aromatase 3.434e-10 0.61
ESR1_HUMAN ESR1 Estrogen receptor 5.648e-10 0.42
GLI1_HUMAN GLI1 Zinc finger protein GLI1 3.044e-09 0.33
SRBP2_HUMAN SREBF2 Sterol regulatory element-binding protein 2 3.699e-09 0.43
RORA_HUMAN RORA Nuclear receptor ROR-alpha 4.339e-09 0.30
ACHA7_MOUSE Chrna7 Neuronal acetylcholine receptor subunit alpha-7 4.239e-08 0.30
DPOLA_HUMAN POLA1 DNA polymerase alpha catalytic subunit 7.354e-08 0.32
SO1A1_RAT Slco1a1 Solute carrier organic anion transporter family member 1A1 2.041e-07 0.30
Q690N0_BOVIN PGR Progesterone receptor 2.61e-07 0.30
HRH3_RAT Hrh3 Histamine H3 receptor 3.209e-07 0.37
ACHA4_MOUSE Chrna4 Neuronal acetylcholine receptor subunit alpha-4 4.359e-07 0.30
EPHA7_HUMAN EPHA7 Ephrin type-A receptor 7 7.087e-06 0.37
EPHA5_HUMAN EPHA5 Ephrin type-A receptor 5 9.363e-06 0.37

Belinostat

HDAC1_HUMAN HDAC1 Histone deacetylase 1 3.077e-106 1.00
HDAC8_HUMAN HDAC8 Histone deacetylase 8 2.417e-87 1.00
HDAC6_HUMAN HDAC6 Histone deacetylase 6 2.779e-59 1.00
HDA11_HUMAN HDAC11 Histone deacetylase 11 3.045e-48 1.00
HDAC9_HUMAN HDAC9 Histone deacetylase 9 8.549e-48 1.00
HDAC2_HUMAN HDAC2 Histone deacetylase 2 6.05e-46 1.00
HDAC5_HUMAN HDAC5 Histone deacetylase 5 7.387e-44 1.00
HDAC4_HUMAN HDAC4 Histone deacetylase 4 1.15e-41 1.00
HDAC7_HUMAN HDAC7 Histone deacetylase 7 2.395e-40 1.00
HDA10_HUMAN HDAC10 Polyamine deacetylase HDAC10 3.374e-32 1.00
Q9XYC7_PLAFA HDAC1 Histone deacetylase 1.517e-27 1.00
HDAC3_HUMAN HDAC3 Histone deacetylase 3 7.654e-24 1.00
BRD4_HUMAN BRD4 Bromodomain-containing protein 4 0.001215 1.00
Q9ZTP8_MAIZE hd1b Histone deacetylase 1.66e-94 0.40
Q94F81_MAIZE hda106 HD2 type histone deacetylase HDA106 5.166e-90 0.43
QCR7_HUMAN UQCRB Cytochrome b-c1 complex subunit 7 1.839e-50 0.37
ARY2_MOUSE Nat2 Arylamine N-acetyltransferase 2 3.876e-48 0.34
SENP2_HUMAN SENP2 Sentrin-specific protease 2 2.088e-47 0.38
SENP1_HUMAN SENP1 Sentrin-specific protease 1 3.147e-42 0.38
DAPAT_ARATH DAP LL-diaminopimelate aminotransferase, chloroplastic 2.89e-41 0.33
O93874_COCLU 17HSDcl 17beta-hydroxysteroid dehydrogenase 9.617e-41 0.32
ARY1_HUMAN NAT1 Arylamine N-acetyltransferase 1 3.409e-40 0.34
RCOR3_HUMAN RCOR3 REST corepressor 3 6.694e-38 0.30
C5ISA2_SHEEP TUBA4A Tubulin alpha chain 8.858e-37 0.29
HDAC1_MOUSE Hdac1 Histone deacetylase 1 1.15e-36 0.42
Q7K6A1_PLAF7 Histone deacetylase 3.307e-36 0.30
LIMK2_HUMAN LIMK2 LIM domain kinase 2 4.995e-32 0.38
Q26964_TRYCR TCTS-154 Trans-sialidase 1.944e-31 0.39
RHOA_HUMAN RHOA Transforming protein RhoA 6.431e-31 0.38
NAMPT_HUMAN NAMPT Nicotinamide phosphoribosyltransferase 4.278e-28 0.41
MMP1_HUMAN MMP1 Interstitial collagenase 2.453e-24 0.50
MMP9_HUMAN MMP9 Matrix metalloproteinase-9 2.6e-24 0.50
MYOC_HUMAN MYOC Myocilin 1.734e-23 0.29
TNI3K_HUMAN TNNI3K Serine/threonine-protein kinase TNNI3K 2.441e-23 0.35
MMP2_HUMAN MMP2 72 kDa type IV collagenase 2.169e-22 0.50
A0A060INS8_CAPHI CTSH Cathepsin H 3.208e-22 0.34
TRPM8_RAT Trpm8 Transient receptor potential cation channel subfamily M member 8 5.003e-22 0.39
PE2R3_HUMAN PTGER3 Prostaglandin E2 receptor EP3 subtype 5.051e-22 0.33
POLG_DEN2P Genome polyprotein 1.142e-20 0.33
F264_HUMAN PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 4.269e-20 0.36
MALX3_YEAST IMA1 Oligo-1,6-glucosidase IMA1 1.575e-19 0.38
STXA_SHIDY stxA Shiga toxin subunit A 1.689e-19 0.40
Q5VLE3_EMEND rmtA RmtA 2.322e-19 0.31
P3C2G_HUMAN PIK3C2G Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma 3.073e-18 0.32
H9B8T9_CAPHI CTSB Cathepsin B 3.203e-18 0.31
AMD_HUMAN PAM Peptidyl-glycine alpha-amidating monooxygenase 4.216e-18 0.30
Q548M1_ECOLX groL 60 kDa chaperonin 1.928e-17 0.33
Q7BGE6_ECOLX groES 10 kDa chaperonin 1.928e-17 0.33
F16P1_HUMAN FBP1 Fructose-1,6-bisphosphatase 1 2.582e-17 0.32
DHB2_HUMAN HSD17B2 Estradiol 17-beta-dehydrogenase 2 5.435e-17 0.38
BXA1_CLOBO botA Botulinum neurotoxin type A 1.11e-16 0.38
CAH4_BOVIN CA4 Carbonic anhydrase 4 1.11e-16 0.39
A5H660_SCHMA HDAC8 Histone deacetylase 8 4.441e-16 0.32
F263_HUMAN PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 1.443e-15 0.46
DHB1_HUMAN HSD17B1 Estradiol 17-beta-dehydrogenase 1 2.22e-15 0.36
PMM2_HUMAN PMM2 Phosphomannomutase 2 2.665e-15 0.32
AOFB_HUMAN MAOB Amine oxidase [flavin-containing] B 2.776e-15 0.51
GP183_HUMAN GPR183 G-protein coupled receptor 183 1.177e-14 0.32
LOX12_HUMAN ALOX12 Arachidonate 12-lipoxygenase, 12S-type 1.188e-14 0.38
MEP1B_HUMAN MEP1B Meprin A subunit beta 1.987e-14 0.36
EAA2_HUMAN SLC1A2 Excitatory amino acid transporter 2 3.02e-14 0.30
KCNQ2_MOUSE Kcnq2 Potassium voltage-gated channel subfamily KQT member 2 4.53e-14 0.33
AK1C3_HUMAN AKR1C3 Aldo-keto reductase family 1 member C3 4.863e-14 0.42
IMDH1_HUMAN IMPDH1 Inosine-5'-monophosphate dehydrogenase 1 7.361e-14 0.41
MGAT1_HUMAN MGAT1 Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase 9.115e-14 0.34
PFKA_TRYCC pfk ATP-dependent 6-phosphofructokinase 9.237e-14 0.31
PPBT_BOVIN ALPL Alkaline phosphatase, tissue-nonspecific isozyme 2.177e-13 0.40
PFKA_TRYBB pfk ATP-dependent 6-phosphofructokinase 7.514e-13 0.31
MGAT2_MOUSE Mgat2 Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase 1.624e-12 0.34
IMDH2_HUMAN IMPDH2 Inosine-5'-monophosphate dehydrogenase 2 8.305e-12 0.41
TRPM2_HUMAN TRPM2 Transient receptor potential cation channel subfamily M member 2 9.7e-12 0.29
RBBP9_HUMAN RBBP9 Serine hydrolase RBBP9 2.665e-11 0.30
MCL1_HUMAN MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 2.677e-11 0.37
TYSY_ECOLI thyA Thymidylate synthase 5.477e-11 0.35
CAH2_HUMAN CA2 Carbonic anhydrase 2 5.519e-11 0.42
P96830_MYCTO TYR_PHOSPHATASE_2 domain-containing protein 5.973e-11 0.30
TTHY_HUMAN TTR Transthyretin 9.478e-11 0.32
RT109_YEAST RTT109 Histone acetyltransferase RTT109 1.167e-10 0.31
GGPPS_YEAST BTS1 Geranylgeranyl pyrophosphate synthase 1.517e-10 0.31
EAA1_HUMAN SLC1A3 Excitatory amino acid transporter 1 3.015e-10 0.30
LIPL_RAT Lpl Lipoprotein lipase 3.195e-10 0.39
CAH1_HUMAN CA1 Carbonic anhydrase 1 3.816e-10 0.42
PPBI_BOVIN ALPI Intestinal-type alkaline phosphatase 4.5e-10 0.40
PRGR_HUMAN PGR Progesterone receptor 4.703e-10 0.50
PAR15_HUMAN PARP15 Protein mono-ADP-ribosyltransferase PARP15 7.541e-10 0.29
AK1A1_RAT Akr1a1 Aldo-keto reductase family 1 member A1 9.421e-10 0.33
NMDZ1_RAT Grin1 Glutamate receptor ionotropic, NMDA 1 1.261e-09 0.36
P3C2B_HUMAN PIK3C2B Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta 2.735e-09 0.32
DHB3_RAT Hsd17b3 Testosterone 17-beta-dehydrogenase 3 2.744e-09 0.37
CHLE_HUMAN BCHE Cholinesterase 4.992e-09 0.36
P90584_PLAFA Pfmrk MO15-related protein kinase Pfmrk 6.576e-09 0.33
FACE2_HUMAN RCE1 CAAX prenyl protease 2 1.012e-08 0.44
HPSE_HUMAN HPSE Heparanase 1.21e-08 0.31
NR0B1_HUMAN NR0B1 Nuclear receptor subfamily 0 group B member 1 1.709e-08 0.30
CLTR1_HUMAN CYSLTR1 Cysteinyl leukotriene receptor 1 1.741e-08 0.30
LT4R1_HUMAN LTB4R Leukotriene B4 receptor 1 1.777e-08 0.42
MGAT3_HUMAN MGAT3 Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase 3.354e-08 0.34
LOX5_RAT Alox5 Arachidonate 5-lipoxygenase 4.459e-08 0.49
INSR_MOUSE Insr Insulin receptor 4.633e-08 0.30
CAH12_HUMAN CA12 Carbonic anhydrase 12 7.146e-08 0.46
NF2L2_HUMAN NFE2L2 Nuclear factor erythroid 2-related factor 2 7.516e-08 0.31
KPYM_HUMAN PKM Pyruvate kinase PKM 9.185e-08 0.32
S12A2_HUMAN SLC12A2 Solute carrier family 12 member 2 9.381e-08 0.33
ALDR_RAT Akr1b1 Aldo-keto reductase family 1 member B1 1.155e-07 0.45
ADRB1_HUMAN ADRB1 Beta-1 adrenergic receptor 1.221e-07 0.37
MTNN_ECOLI mtnN 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 1.813e-07 0.31
CAH9_HUMAN CA9 Carbonic anhydrase 9 2.469e-07 0.46
MMP26_HUMAN MMP26 Matrix metalloproteinase-26 2.994e-07 0.28
PI2R_HUMAN PTGIR Prostacyclin receptor 3.926e-07 0.39
S40A1_HUMAN SLC40A1 Solute carrier family 40 member 1 4.052e-07 0.30
MAP2_HUMAN METAP2 Methionine aminopeptidase 2 4.208e-07 0.37
PF2R_HUMAN PTGFR Prostaglandin F2-alpha receptor 4.327e-07 0.31
ADRB3_HUMAN ADRB3 Beta-3 adrenergic receptor 4.996e-07 0.37
PGES2_HUMAN PTGES2 Prostaglandin E synthase 2 5.685e-07 0.33
NCOR2_HUMAN NCOR2 Nuclear receptor corepressor 2 7.951e-07 0.33
ADRB2_HUMAN ADRB2 Beta-2 adrenergic receptor 1.049e-06 0.37
STAT1_HUMAN STAT1 Signal transducer and activator of transcription 1-alpha/beta 1.579e-06 0.40
ACLY_HUMAN ACLY ATP-citrate synthase 1.651e-06 0.30
P4HTM_HUMAN P4HTM Transmembrane prolyl 4-hydroxylase 1.95e-06 0.30
CAH2_BOVIN CA2 Carbonic anhydrase 2 2.013e-06 0.35
PLEC_HUMAN PLEC Plectin 2.856e-06 0.33
GABT_RAT Abat 4-aminobutyrate aminotransferase, mitochondrial 3.101e-06 0.33
PE2R2_HUMAN PTGER2 Prostaglandin E2 receptor EP2 subtype 3.408e-06 0.39
EAA3_HUMAN SLC1A1 Excitatory amino acid transporter 3 3.486e-06 0.29
5HT6R_HUMAN HTR6 5-hydroxytryptamine receptor 6 3.797e-06 0.45
FABP4_HUMAN FABP4 Fatty acid-binding protein, adipocyte 4.182e-06 0.31
KCNQ3_HUMAN KCNQ3 Potassium voltage-gated channel subfamily KQT member 3 4.376e-06 0.33
O49150_SOLTU Lipoxygenase 5.557e-06 0.29
Q8I2J3_PLAF7 M18 aspartyl aminopeptidase 5.63e-06 0.42
S12A5_HUMAN SLC12A5 Solute carrier family 12 member 5 7.334e-06 0.33
MMP15_HUMAN MMP15 Matrix metalloproteinase-15 8.558e-06 0.28
BRPF3_HUMAN BRPF3 Bromodomain and PHD finger-containing protein 3 9.884e-06 0.32

Indacaterol

ADRB2_HUMAN ADRB2 Beta-2 adrenergic receptor 4.927e-105 1.00
ADRB2_CAVPO Adrb2 Beta-2 adrenergic receptor 2.761e-58 1.00
ADRB1_HUMAN ADRB1 Beta-1 adrenergic receptor 1.957e-50 1.00
DRD3_HUMAN DRD3 D(3) dopamine receptor 2.094e-05 1.00
ACM3_HUMAN CHRM3 Muscarinic acetylcholine receptor M3 2.817e-52 0.43
ADRB1_MOUSE Adrb1 Beta-1 adrenergic receptor 4.211e-28 0.43
ADRB1_RAT Adrb1 Beta-1 adrenergic receptor 5.473e-25 0.44
ADRB3_HUMAN ADRB3 Beta-3 adrenergic receptor 1.428e-10 0.43
ADA1D_HUMAN ADRA1D Alpha-1D adrenergic receptor 1.177e-09 0.43

Alogliptin

DPP4_HUMAN DPP4 Dipeptidyl peptidase 4 1.559e-97 1.00
PADI4_HUMAN PADI4 Protein-arginine deiminase type-4 6.813e-32 0.31
DPP4_BOVIN DPP4 Dipeptidyl peptidase 4 2.111e-30 0.38
SEPR_HUMAN FAP Prolyl endopeptidase FAP 4.176e-17 0.42
PRGR_HUMAN PGR Progesterone receptor 8.549e-15 0.35
DPP4_RAT Dpp4 Dipeptidyl peptidase 4 1.849e-11 0.63
KDM1A_HUMAN KDM1A Lysine-specific histone demethylase 1A 1.182e-09 0.31
NOS3_HUMAN NOS3 Nitric oxide synthase, endothelial 5.939e-07 0.33
FADS1_RAT Fads1 Acyl-CoA (8-3)-desaturase 2.889e-06 0.32
NOS2_HUMAN NOS2 Nitric oxide synthase, inducible 6.685e-06 0.33

Alvimopan

OPRM_RAT Oprm1 Mu-type opioid receptor 3.645e-91 1.00
OPRK_CAVPO OPRK1 Kappa-type opioid receptor 1.052e-82 1.00
OPRD_HUMAN OPRD1 Delta-type opioid receptor 3.82e-71 1.00
OPRM_HUMAN OPRM1 Mu-type opioid receptor 1.472e-60 1.00
OPRK_HUMAN OPRK1 Kappa-type opioid receptor 1.759e-51 1.00
OPRD_RAT Oprd1 Delta-type opioid receptor 2.795e-42 1.00
OPRM_CAVPO OPRM1 Mu-type opioid receptor 3.14e-41 1.00
OPRD_MOUSE Oprd1 Delta-type opioid receptor 4.465e-34 1.00
CAC1C_HUMAN CACNA1C Voltage-dependent L-type calcium channel subunit alpha-1C 5.715e-06 1.00
NEP_RAT Mme Neprilysin 1.615e-73 0.42
NK2R_HUMAN TACR2 Substance-K receptor 2.754e-55 0.33
NEP_RABIT MME Neprilysin 3.737e-53 0.41
CHLE_MOUSE Bche Cholinesterase 9.583e-49 0.31
NEP_MOUSE Mme Neprilysin 2.221e-39 0.31
HMDH_MESAU HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase 3.644e-39 0.32
Q8CGM4_CAVPO OPRM1 Mu-opioid receptor 4.156e-38 0.33
NK2R_CAVPO TACR2 Substance-K receptor 4.899e-38 0.32
ACE_RAT Ace Angiotensin-converting enzyme 5.524e-38 0.39
CBPA3_HUMAN CPA3 Mast cell carboxypeptidase A 2.337e-35 0.29
OPRM_MOUSE Oprm1 Mu-type opioid receptor 1.26e-27 0.36
OPRK_MOUSE Oprk1 Kappa-type opioid receptor 1.582e-26 0.33
GLO2_RAT Hagh Hydroxyacylglutathione hydrolase, mitochondrial 3.914e-24 0.30
NEP_HUMAN MME Neprilysin 1.049e-23 0.41
OPRK_RAT Oprk1 Kappa-type opioid receptor 7.043e-23 0.49
NTCP_HUMAN SLC10A1 Sodium/bile acid cotransporter 1.181e-20 0.31
SOAT1_CHLAE SOAT1 Sterol O-acyltransferase 1 1.675e-19 0.30
S15A1_HUMAN SLC15A1 Solute carrier family 15 member 1 9.469e-19 0.36
GLUT4_HUMAN SLC2A4 Solute carrier family 2, facilitated glucose transporter member 4 1.126e-18 0.30
ACES_MOUSE Ache Acetylcholinesterase 9.095e-18 0.31
AMD_RAT Pam Peptidylglycine alpha-amidating monooxygenase 1.282e-17 0.35
ACE_RABIT ACE Angiotensin-converting enzyme 2.22e-16 0.41
PTPRC_HUMAN PTPRC Receptor-type tyrosine-protein phosphatase C 6.661e-16 0.30
AMPL_PIG LAP3 Cytosol aminopeptidase 9.992e-16 0.35
SOAT2_CHLAE SOAT2 Sterol O-acyltransferase 2 3.997e-15 0.30
AMPN_PIG ANPEP Aminopeptidase N 1.432e-14 0.40
ACE_HUMAN ACE Angiotensin-converting enzyme 1.676e-14 0.41
ACE_MOUSE Ace Angiotensin-converting enzyme 4.208e-14 0.31
PP2AA_BOVIN PPP2CA Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 1.704e-13 0.29
F7HEV7_MACMU YTHDF2 G_PROTEIN_RECEP_F1_2 domain-containing protein 4.673e-13 0.28
H9FL65_MACMU OPRK1 Kappa-type opioid receptor 4.673e-13 0.28
B3DH72_DANRE oprd1b Opioid receptor, delta 1b 9.167e-13 0.31
O57585_DANRE oprd1a Opioid receptor homologue 9.167e-13 0.31
OPRM_MACMU OPRM1 Mu-type opioid receptor 1.133e-11 0.28
Q98UH1_DANRE oprm1 Mu opioid receptor-like OR2 1.309e-11 0.31
OPRM_BOVIN OPRM1 Mu-type opioid receptor 3.658e-11 0.32
ERAP2_HUMAN ERAP2 Endoplasmic reticulum aminopeptidase 2 8.037e-11 0.35
CDYL2_HUMAN CDYL2 Chromodomain Y-like protein 2 1.103e-10 0.29
S15A2_RAT Slc15a2 Solute carrier family 15 member 2 1.269e-10 0.36
THER_BACTH npr Thermolysin 1.669e-10 0.41
PPM1B_HUMAN PPM1B Protein phosphatase 1B 7.778e-09 0.29
SGMR1_HUMAN SIGMAR1 Sigma non-opioid intracellular receptor 1 9.432e-09 0.34
CATL1_BOVIN CTSL Cathepsin L1 1.259e-08 0.29
SGMR1_MOUSE Sigmar1 Sigma non-opioid intracellular receptor 1 1.326e-08 0.30
ACE2_HUMAN ACE2 Angiotensin-converting enzyme 2 1.944e-08 0.30
SGMR1_RAT Sigmar1 Sigma non-opioid intracellular receptor 1 2.137e-08 0.34
AMPN_HUMAN ANPEP Aminopeptidase N 3.264e-08 0.35
HMDH_HUMAN HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase 4.357e-08 0.32
GSTO1_HUMAN GSTO1 Glutathione S-transferase omega-1 6.433e-08 0.33
OPRX_HUMAN OPRL1 Nociceptin receptor 7.494e-08 0.34
ADRM1_HUMAN ADRM1 Proteasomal ubiquitin receptor ADRM1 2.616e-07 0.33
PRS10_HUMAN PSMC6 26S proteasome regulatory subunit 10B 2.616e-07 0.33
PRS4_HUMAN PSMC1 26S proteasome regulatory subunit 4 2.616e-07 0.33
PRS6A_HUMAN PSMC3 26S proteasome regulatory subunit 6A 2.616e-07 0.33
PRS6B_HUMAN PSMC4 26S proteasome regulatory subunit 6B 2.616e-07 0.33
PRS7_HUMAN PSMC2 26S proteasome regulatory subunit 7 2.616e-07 0.33
PRS8_HUMAN PSMC5 26S proteasome regulatory subunit 8 2.616e-07 0.33
PSD11_HUMAN PSMD11 26S proteasome non-ATPase regulatory subunit 11 2.616e-07 0.33
PSD12_HUMAN PSMD12 26S proteasome non-ATPase regulatory subunit 12 2.616e-07 0.33
PSD13_HUMAN PSMD13 26S proteasome non-ATPase regulatory subunit 13 2.616e-07 0.33
PSMD1_HUMAN PSMD1 26S proteasome non-ATPase regulatory subunit 1 2.616e-07 0.33
PSMD2_HUMAN PSMD2 26S proteasome non-ATPase regulatory subunit 2 2.616e-07 0.33
PSMD3_HUMAN PSMD3 26S proteasome non-ATPase regulatory subunit 3 2.616e-07 0.33
PSMD4_HUMAN PSMD4 26S proteasome non-ATPase regulatory subunit 4 2.616e-07 0.33
PSMD6_HUMAN PSMD6 26S proteasome non-ATPase regulatory subunit 6 2.616e-07 0.33
PSMD7_HUMAN PSMD7 26S proteasome non-ATPase regulatory subunit 7 2.616e-07 0.33
PSMD8_HUMAN PSMD8 26S proteasome non-ATPase regulatory subunit 8 2.616e-07 0.33
SEM1_HUMAN SEM1 26S proteasome complex subunit SEM1 2.616e-07 0.33
GP142_MOUSE Gpr142 Probable G-protein coupled receptor 142 4.12e-07 0.29
CBPA1_HUMAN CPA1 Carboxypeptidase A1 5.45e-07 0.28
MMEL1_HUMAN MMEL1 Membrane metallo-endopeptidase-like 1 7.79e-07 0.31
GRB2_HUMAN GRB2 Growth factor receptor-bound protein 2 8.42e-07 0.30
PLD1_HUMAN PLD1 Phospholipase D1 9.097e-07 0.30
SCN4A_HUMAN SCN4A Sodium channel protein type 4 subunit alpha 1.108e-06 0.29
TPH1_HUMAN TPH1 Tryptophan 5-hydroxylase 1 1.696e-06 0.30
BLA1_STEMA Metallo-beta-lactamase L1 type 3 2.415e-06 0.28
Q72874_9HIV1 pol Pol polyprotein 2.689e-06 0.34
SCN2A_RAT Scn2a Sodium channel protein type 2 subunit alpha 6.746e-06 0.32
NALD2_HUMAN NAALAD2 N-acetylated-alpha-linked acidic dipeptidase 2 7.705e-06 0.28
CCR2_HUMAN CCR2 C-C chemokine receptor type 2 8.33e-06 0.34
SYYC_HUMAN YARS1 Tyrosine--tRNA ligase, cytoplasmic 9.133e-06 0.29

Ambrisentan

EDNRB_HUMAN EDNRB Endothelin receptor type B 2.322e-86 1.00
EDNRA_HUMAN EDNRA Endothelin-1 receptor 2.202e-63 1.00
Q8S3J0_BROTE ALS Acetolactate synthase 1.948e-36 0.29
KIF11_HUMAN KIF11 Kinesin-like protein KIF11 1.275e-13 0.35
ILVB_ARATH ALS Acetolactate synthase, chloroplastic 3.185e-13 0.29
J7HAW4_RAPRA Acetolactate synthase 9.112e-11 0.29
SORT_HUMAN SORT1 Sortilin 1.839e-10 0.31
ILVB_YEAST ILV2 Acetolactate synthase catalytic subunit, mitochondrial 2.125e-10 0.33
ATP6_MYCTU atpB ATP synthase subunit a 1.322e-08 0.29
ATPA_MYCTU atpA ATP synthase subunit alpha 1.322e-08 0.29
ATPB_MYCTU atpD ATP synthase subunit beta 1.322e-08 0.29
ATPE_MYCTU atpC ATP synthase epsilon chain 1.322e-08 0.29
ATPFD_MYCTU atpFH ATP synthase subunit b-delta 1.322e-08 0.29
ATPF_MYCTU atpF ATP synthase subunit b 1.322e-08 0.29
ATPG_MYCTU atpG ATP synthase gamma chain 1.322e-08 0.29
ATPL_MYCTU atpE ATP synthase subunit c 1.322e-08 0.29
C11B1_BOVIN CYP11B1 Cytochrome P450 11B1, mitochondrial 8.227e-07 0.29
TS1R1_HUMAN TAS1R1 Taste receptor type 1 member 1 2.726e-06 0.30

Romidepsin

PAK1_MOUSE Pak1 Serine/threonine-protein kinase PAK 1 2.714e-79 1.00
HDAC6_MOUSE Hdac6 Histone deacetylase 6 4.114e-27 1.00
Q9XYC7_PLAFA HDAC1 Histone deacetylase 1.144e-14 1.00
NCOR1_HUMAN NCOR1 Nuclear receptor corepressor 1 9.469e-13 1.00
NCOR2_HUMAN NCOR2 Nuclear receptor corepressor 2 1.736e-12 1.00
HDA10_HUMAN HDAC10 Polyamine deacetylase HDAC10 3.819e-12 1.00
HDAC7_HUMAN HDAC7 Histone deacetylase 7 4.278e-11 1.00
HDA11_HUMAN HDAC11 Histone deacetylase 11 5.342e-07 1.00
HDAC2_HUMAN HDAC2 Histone deacetylase 2 7.179e-07 1.00
HDAC9_HUMAN HDAC9 Histone deacetylase 9 3.921e-06 1.00
HDAC6_HUMAN HDAC6 Histone deacetylase 6 4.37e-06 1.00
HDAC5_HUMAN HDAC5 Histone deacetylase 5 5.715e-06 1.00
HDAC1_HUMAN HDAC1 Histone deacetylase 1 1.697e-05 1.00
HDAC4_HUMAN HDAC4 Histone deacetylase 4 2.073e-05 1.00
HDAC3_HUMAN HDAC3 Histone deacetylase 3 2.521e-05 1.00
HDAC8_HUMAN HDAC8 Histone deacetylase 8 0.001675 1.00
PAK1_HUMAN PAK1 Serine/threonine-protein kinase PAK 1 0.002758 1.00
BRD4_HUMAN BRD4 Bromodomain-containing protein 4 0.6937 1.00
AGRA_STAAU agrA Accessory gene regulator protein A 6.822e-26 0.34

Simeprevir

A0A0K1CY61_9HEPC Nonstructural protein NS3-4A 2.9e-78 1.00
D2K2A8_9HEPC NS4A Non-structural protein 4A 2.732e-24 1.00
A3EZI9_9HEPC NS3 Genome polyprotein 2.349e-17 1.00
CATS_HUMAN CTSS Cathepsin S 0.7458 1.00
SC5A7_HUMAN SLC5A7 High affinity choline transporter 1 1.972e-21 0.28
C1KIQ2_9HEPC NS3 protease 6.158e-18 0.34
K7XJL6_9HEPC Genome polyprotein 1.554e-15 0.29
Q91RS4_9HEPC NS3 protease 1.292e-07 0.40

Cobimetinib

MP2K1_HUMAN MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 5.366e-78 1.00
BRAF_HUMAN BRAF Serine/threonine-protein kinase B-raf 0.9676 1.00
MP2K1_MOUSE Map2k1 Dual specificity mitogen-activated protein kinase kinase 1 4.298e-52 0.44
M3K9_HUMAN MAP3K9 Mitogen-activated protein kinase kinase kinase 9 6.349e-08 0.34

Obeticholic_acid

GPBAR_HUMAN GPBAR1 G-protein coupled bile acid receptor 1 1.204e-75 1.00
NR1H4_HUMAN NR1H4 Bile acid receptor 6.831e-33 1.00
EPHA2_MOUSE Epha2 Ephrin type-A receptor 2 9.73e-89 0.49
SIA4B_RAT St3gal2 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 2.769e-85 0.45
NTCP_HUMAN SLC10A1 Sodium/bile acid cotransporter 9.138e-77 0.67
NPCL1_HUMAN NPC1L1 NPC1-like intracellular cholesterol transporter 1 7.601e-59 0.48
CDC45_HUMAN CDC45 Cell division control protein 45 homolog 5.316e-52 0.41
CAH4_BOVIN CA4 Carbonic anhydrase 4 8.719e-47 0.45
DHC24_HUMAN DHCR24 Delta(24)-sterol reductase 3.33e-46 0.41
3BHS_MYCTU 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase 1.046e-40 0.35
NTCP2_HUMAN SLC10A2 Ileal sodium/bile acid cotransporter 3.275e-40 0.67
SIA4A_HUMAN ST3GAL1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 8.439e-40 0.44
MRP4_HUMAN ABCC4 Multidrug resistance-associated protein 4 6.216e-39 0.46
VDR_PIG VDR Vitamin D3 receptor 1.71e-35 0.28
VTDB_HUMAN GC Vitamin D-binding protein 1.71e-35 0.28
VDRA_DANRE vdra Vitamin D3 receptor A 1.336e-34 0.28
NPC1_HUMAN NPC1 NPC intracellular cholesterol transporter 1 4.318e-34 0.35
MPIP1_HUMAN CDC25A M-phase inducer phosphatase 1 9.363e-33 0.43
CP125_MYCTU cyp125 Steroid C26-monooxygenase 5.082e-32 0.40
CRYAB_HUMAN CRYAB Alpha-crystallin B chain 1.765e-29 0.36
DHCR7_RAT Dhcr7 7-dehydrocholesterol reductase 1.077e-27 0.36
S5A1_HUMAN SRD5A1 3-oxo-5-alpha-steroid 4-dehydrogenase 1 1.211e-26 0.41
CD4_HUMAN CD4 T-cell surface glycoprotein CD4 1.382e-25 0.32
VDR_RAT Vdr Vitamin D3 receptor 2.652e-25 0.31
SMT1_ARATH SMT1 Cycloartenol-C-24-methyltransferase 1.344e-24 0.39
G6PD_HUMAN G6PD Glucose-6-phosphate 1-dehydrogenase 6.219e-24 0.31
NTCP_RAT Slc10a1 Sodium/bile acid cotransporter 1.072e-23 0.38
S5A2_HUMAN SRD5A2 3-oxo-5-alpha-steroid 4-dehydrogenase 2 2.914e-23 0.41
VDR_CHICK VDR Vitamin D3 receptor 2.871e-22 0.28
ABCBB_HUMAN ABCB11 Bile salt export pump 5.38e-22 0.55
REST_BORBU resT Telomere resolvase ResT 6.172e-20 0.50
CAH2_HUMAN CA2 Carbonic anhydrase 2 3.053e-17 0.45
CAH1_HUMAN CA1 Carbonic anhydrase 1 1.11e-16 0.45
VDR_HUMAN VDR Vitamin D3 receptor 3.775e-15 0.62
AT12A_HUMAN ATP12A Potassium-transporting ATPase alpha chain 2 1.166e-14 0.29
RORA_HUMAN RORA Nuclear receptor ROR-alpha 8.574e-13 0.44
DPOLB_RAT Polb DNA polymerase beta 2.592e-12 0.62
ENPP2_HUMAN ENPP2 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 3.262e-12 0.41
NR1H3_HUMAN NR1H3 Oxysterols receptor LXR-alpha 6.479e-12 0.52
EPHA7_HUMAN EPHA7 Ephrin type-A receptor 7 1.183e-10 0.38
EPHA5_HUMAN EPHA5 Ephrin type-A receptor 5 2.005e-10 0.38
MPIP2_HUMAN CDC25B M-phase inducer phosphatase 2 2.039e-10 0.38
EPHA8_HUMAN EPHA8 Ephrin type-A receptor 8 5.297e-10 0.38
EPHB3_HUMAN EPHB3 Ephrin type-B receptor 3 5.297e-10 0.38
VDR_BOVIN VDR Vitamin D3 receptor 1.104e-09 0.28
EPHA4_HUMAN EPHA4 Ephrin type-A receptor 4 1.269e-09 0.38
DPOLA_HUMAN POLA1 DNA polymerase alpha catalytic subunit 1.325e-09 0.41
SHH_MOUSE Shh Sonic hedgehog protein 3.839e-09 0.35
ECR_DROME EcR Ecdysone receptor 3.998e-09 0.32
EPHA1_HUMAN EPHA1 Ephrin type-A receptor 1 4.048e-09 0.38
EPHB1_HUMAN EPHB1 Ephrin type-B receptor 1 4.048e-09 0.38
EPHA6_HUMAN EPHA6 Ephrin type-A receptor 6 5.757e-09 0.38
EPHB2_HUMAN EPHB2 Ephrin type-B receptor 2 8.063e-09 0.38
FGF1_HUMAN FGF1 Fibroblast growth factor 1 8.815e-09 0.29
GBRD_HUMAN GABRD Gamma-aminobutyric acid receptor subunit delta 3.012e-08 0.31
EPHB6_HUMAN EPHB6 Ephrin type-B receptor 6 3.576e-08 0.38
SRBP2_HUMAN SREBF2 Sterol regulatory element-binding protein 2 8.356e-08 0.36
EPHA2_HUMAN EPHA2 Ephrin type-A receptor 2 1.314e-07 0.43
EPHA3_HUMAN EPHA3 Ephrin type-A receptor 3 2.33e-07 0.38
GPBAR_MOUSE Gpbar1 G-protein coupled bile acid receptor 1 4.46e-07 0.75
SIAT1_HUMAN ST6GAL1 Beta-galactoside alpha-2,6-sialyltransferase 1 6.323e-07 0.34
Q8IEK1_PLAF7 M1-family alanyl aminopeptidase 7.646e-07 0.67
SHBG_HUMAN SHBG Sex hormone-binding globulin 9.417e-07 0.32
GABR1_RAT Gabbr1 Gamma-aminobutyric acid type B receptor subunit 1 1.12e-06 0.31
CISD1_HUMAN CISD1 CDGSH iron-sulfur domain-containing protein 1 2.86e-06 0.67

Rotigotine

DRD2_BOVIN DRD2 D(2) dopamine receptor 1.048e-64 1.00
DRD3_HUMAN DRD3 D(3) dopamine receptor 5.495e-48 1.00
DRD2_HUMAN DRD2 D(2) dopamine receptor 1.326e-38 1.00
DRD1_BOVIN DRD1 D(1A) dopamine receptor 2.367e-23 1.00
DRD4_HUMAN DRD4 D(4) dopamine receptor 4.707e-19 1.00
DRD1_HUMAN DRD1 D(1A) dopamine receptor 1.99e-18 1.00
DRD3_RAT Drd3 D(3) dopamine receptor 4.944e-124 0.72
DRD2_RAT Drd2 D(2) dopamine receptor 1.95e-54 0.72
5HT1A_RAT Htr1a 5-hydroxytryptamine receptor 1A 4.474e-48 0.61
5HT1D_HUMAN HTR1D 5-hydroxytryptamine receptor 1D 1.101e-21 0.61
5HT1B_HUMAN HTR1B 5-hydroxytryptamine receptor 1B 6.146e-19 0.60
5HT1A_MOUSE Htr1a 5-hydroxytryptamine receptor 1A 1.11e-16 0.60
5HT7R_RAT Htr7 5-hydroxytryptamine receptor 7 5.551e-16 0.60
ADA2A_BOVIN ADRA2A Alpha-2A adrenergic receptor 1.732e-11 0.60
5HT5A_RAT Htr5a 5-hydroxytryptamine receptor 5A 6.224e-11 0.31
5HT2A_BOVIN HTR2A 5-hydroxytryptamine receptor 2A 9.615e-11 0.34
5HT1A_HUMAN HTR1A 5-hydroxytryptamine receptor 1A 2.993e-09 0.60
DRD1_PIG DRD1 D(1A) dopamine receptor 7.466e-09 0.32
5HT1B_RAT Htr1b 5-hydroxytryptamine receptor 1B 8.077e-06 0.60

Sertindole

ADA1A_BOVIN ADRA1A Alpha-1A adrenergic receptor 1.145e-60 1.00
DRD2_RAT Drd2 D(2) dopamine receptor 1.307e-54 1.00
ADA1B_MESAU ADRA1B Alpha-1B adrenergic receptor 9.573e-50 1.00
ADA1A_RAT Adra1a Alpha-1A adrenergic receptor 6.404e-43 1.00
5HT2A_RAT Htr2a 5-hydroxytryptamine receptor 2A 2.03e-40 1.00
5HT2C_RAT Htr2c 5-hydroxytryptamine receptor 2C 5.323e-31 1.00
5HT1B_HUMAN HTR1B 5-hydroxytryptamine receptor 1B 1.402e-27 1.00
ADA1D_RAT Adra1d Alpha-1D adrenergic receptor 1.466e-25 1.00
5HT1A_HUMAN HTR1A 5-hydroxytryptamine receptor 1A 1.066e-14 1.00
DRD2_HUMAN DRD2 D(2) dopamine receptor 4.285e-14 1.00
DRD1_RAT Drd1 D(1A) dopamine receptor 7.273e-13 1.00
DRD3_HUMAN DRD3 D(3) dopamine receptor 2.02e-11 1.00
KCNH2_HUMAN KCNH2 Potassium voltage-gated channel subfamily H member 2 2.973e-11 1.00
5HT2A_HUMAN HTR2A 5-hydroxytryptamine receptor 2A 2.296e-09 1.00
5HT6R_HUMAN HTR6 5-hydroxytryptamine receptor 6 1.825e-08 1.00
DRD4_HUMAN DRD4 D(4) dopamine receptor 7.574e-08 1.00
HRH1_HUMAN HRH1 Histamine H1 receptor 1.226e-07 1.00
5HT2C_HUMAN HTR2C 5-hydroxytryptamine receptor 2C 4.176e-07 1.00
DRD1_HUMAN DRD1 D(1A) dopamine receptor 1.51e-05 1.00
MDR1_HUMAN ABCB1 ATP-dependent translocase ABCB1 0.02475 1.00
KCNA5_HUMAN KCNA5 Potassium voltage-gated channel subfamily A member 5 0.07391 1.00
O19067_PIG N-methyl-D-aspartate receptor 1.381e-38 0.31
CRY2_HUMAN CRY2 Cryptochrome-2 7.502e-31 0.38
PLD2_HUMAN PLD2 Phospholipase D2 9.719e-31 0.37
PLD1_HUMAN PLD1 Phospholipase D1 4.421e-28 0.37
CCR3_MOUSE Ccr3 Probable C-C chemokine receptor type 3 6.546e-27 0.32
CCR3_RAT Ccr3 C-C chemokine receptor type 3 1.286e-26 0.31
DRD4_RAT Drd4 D(4) dopamine receptor 6.734e-21 0.35
HRH1_CAVPO HRH1 Histamine H1 receptor 2.849e-17 0.34
HRH2_HUMAN HRH2 Histamine H2 receptor 1.11e-16 0.34
KDM4B_HUMAN KDM4B Lysine-specific demethylase 4B 3.331e-16 0.33
SGMR1_RAT Sigmar1 Sigma non-opioid intracellular receptor 1 3.65e-13 0.40
VMAT2_MOUSE Slc18a2 Synaptic vesicular amine transporter 6.016e-12 0.29
MURB_STAAU murB UDP-N-acetylenolpyruvoylglucosamine reductase 6.736e-12 0.29
ADA1B_HUMAN ADRA1B Alpha-1B adrenergic receptor 2.856e-11 0.36
KDM5C_HUMAN KDM5C Lysine-specific demethylase 5C 2.912e-11 0.33
MURA_ECOLI murA UDP-N-acetylglucosamine 1-carboxyvinyltransferase 7.946e-11 0.29
5HT7R_HUMAN HTR7 5-hydroxytryptamine receptor 7 1.099e-10 0.36
ADA1D_HUMAN ADRA1D Alpha-1D adrenergic receptor 1.893e-10 0.33
NMD3A_RAT Grin3a Glutamate receptor ionotropic, NMDA 3A 2.194e-10 0.30
KDM3A_HUMAN KDM3A Lysine-specific demethylase 3A 2.81e-10 0.29
ADA1A_HUMAN ADRA1A Alpha-1A adrenergic receptor 2.944e-09 0.33
KDM4A_HUMAN KDM4A Lysine-specific demethylase 4A 7.822e-09 0.33
5HT1A_RAT Htr1a 5-hydroxytryptamine receptor 1A 9.406e-09 0.36
SCN8A_HUMAN SCN8A Sodium channel protein type 8 subunit alpha 4.531e-08 0.36
VMAT2_HUMAN SLC18A2 Synaptic vesicular amine transporter 7.608e-08 0.29
ADA1B_RAT Adra1b Alpha-1B adrenergic receptor 8.731e-08 0.33
KDM5B_HUMAN KDM5B Lysine-specific demethylase 5B 1.864e-07 0.33
MCHR1_HUMAN MCHR1 Melanin-concentrating hormone receptor 1 2.106e-07 0.35
PLD1_RAT Pld1 Phospholipase D1 2.436e-07 0.37
Q8MMZ8_EIMTE cGMP-dependent protein kinase 3.765e-06 0.30
GYRB_MYCTU gyrB DNA gyrase subunit B 4.928e-06 0.28
MCHR1_RAT Mchr1 Melanin-concentrating hormone receptor 1 6.479e-06 0.33
FADS1_RAT Fads1 Acyl-CoA (8-3)-desaturase 6.674e-06 0.30
S22A2_HUMAN SLC22A2 Solute carrier family 22 member 2 7.334e-06 0.33
KDM2A_HUMAN KDM2A Lysine-specific demethylase 2A 7.926e-06 0.28

Cangrelor

GPR17_HUMAN GPR17 Uracil nucleotide/cysteinyl leukotriene receptor 5.245e-59 1.00
P2Y12_HUMAN P2RY12 P2Y purinoceptor 12 1.385e-11 1.00
P2RY2_HUMAN P2RY2 P2Y purinoceptor 2 1.548e-217 0.47
P2RY6_HUMAN P2RY6 P2Y purinoceptor 6 1.037e-204 0.47
P2RY4_HUMAN P2RY4 P2Y purinoceptor 4 2.23e-157 0.45
P2RY1_MELGA P2RY1 P2Y purinoceptor 1 9.982e-135 0.65
P2Y14_HUMAN P2RY14 P2Y purinoceptor 14 1.113e-130 0.39
DNPH1_HUMAN DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 3.544e-123 0.41
DNPH1_RAT Dnph1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 2.107e-121 0.41
P2RY1_RAT P2ry1 P2Y purinoceptor 1 4.022e-101 0.51
AA1R_RAT Adora1 Adenosine receptor A1 2.417e-95 0.40
MBTA_MYCTU mbtA Salicyl-AMP ligase / salicyl-S-ArCP synthetase 5.125e-86 0.37
P2Y11_HUMAN P2RY11 P2Y purinoceptor 11 1.911e-83 0.69
AA3R_HUMAN ADORA3 Adenosine receptor A3 3.364e-80 0.42
G3PC_LEIME GAPC Glyceraldehyde-3-phosphate dehydrogenase, cytosolic 4.112e-76 0.30
KAD2_RAT Ak2 Adenylate kinase 2, mitochondrial 1.582e-75 0.44
P2RY4_RAT P2ry4 P2Y purinoceptor 4 4.61e-73 0.44
RASK_HUMAN KRAS GTPase KRas 5.105e-73 0.42
FUT6_HUMAN FUT6 Alpha-(1,3)-fucosyltransferase 6 1.403e-71 0.33
PARG_BOVIN PARG Poly(ADP-ribose) glycohydrolase 9.78e-71 0.39
KAD3_RAT Ak3 GTP:AMP phosphotransferase AK3, mitochondrial 3.738e-68 0.44
SNAT_SHEEP AANAT Serotonin N-acetyltransferase 1.212e-67 0.31
IMDH2_MOUSE Impdh2 Inosine-5'-monophosphate dehydrogenase 2 6.144e-67 0.39
ASNS_HUMAN ASNS Asparagine synthetase [glutamine-hydrolyzing] 1.165e-66 0.37
IF4E_RABIT EIF4E Eukaryotic translation initiation factor 4E 1.348e-66 0.41
P2RX1_HUMAN P2RX1 P2X purinoceptor 1 4.996e-66 0.51
AA1R_HUMAN ADORA1 Adenosine receptor A1 1.439e-63 0.42
AA1R_CHICK ADORA1 Adenosine receptor A1 2.533e-62 0.32
IMDH1_HUMAN IMPDH1 Inosine-5'-monophosphate dehydrogenase 1 7.586e-62 0.41
KTHY_HUMAN DTYMK Thymidylate kinase 5.887e-61 0.36
DHE3_BOVIN GLUD1 Glutamate dehydrogenase 1, mitochondrial 6.207e-60 0.39
AA3R_RAT Adora3 Adenosine receptor A3 1.007e-59 0.37
DNM3B_HUMAN DNMT3B DNA (cytosine-5)-methyltransferase 3B 1.957e-59 0.32
AA2AR_RAT Adora2a Adenosine receptor A2a 5.628e-58 0.40
METK1_RAT Mat1a S-adenosylmethionine synthase isoform type-1 5.979e-58 0.33
S29A1_HUMAN SLC29A1 Equilibrative nucleoside transporter 1 3.887e-57 0.34
P2RX5_RAT P2rx5 P2X purinoceptor 5 1.412e-56 0.51
P2RX6_RAT P2rx6 P2X purinoceptor 6 1.412e-56 0.51
MTAP_MOUSE Mtap S-methyl-5'-thioadenosine phosphorylase 4.773e-56 0.30
MACD1_HUMAN MACROD1 ADP-ribose glycohydrolase MACROD1 3.652e-54 0.43
MACD2_HUMAN MACROD2 ADP-ribose glycohydrolase MACROD2 3.652e-54 0.43
SYRC_HUMAN RARS1 Arginine--tRNA ligase, cytoplasmic 5.799e-54 0.39
RN5A_MOUSE Rnasel 2-5A-dependent ribonuclease 1.198e-53 0.37
ENTE_ECOLI entE Enterobactin synthase component E 2.079e-53 0.34
HSP7C_BOVIN HSPA8 Heat shock cognate 71 kDa protein 2.335e-53 0.43
WALK_STAAU walK Sensor protein kinase WalK 2.335e-53 0.43
METK2_RAT Mat2a S-adenosylmethionine synthase isoform type-2 2.084e-52 0.42
MENB_MYCTU menB 1,4-dihydroxy-2-naphthoyl-CoA synthase 2.887e-52 0.33
PANE_ECOLI panE 2-dehydropantoate 2-reductase 2.78e-51 0.32
ADRB2_MESAU ADRB2 Beta-2 adrenergic receptor 1.812e-50 0.30
ADK_TOXGO AK Adenosine kinase 1.918e-50 0.34
RNAS1_HUMAN RNASE1 Ribonuclease pancreatic 5.065e-49 0.32
RNAS2_HUMAN RNASE2 Non-secretory ribonuclease 5.065e-49 0.32
ENTP1_BOVIN ENTPD1 Ectonucleoside triphosphate diphosphohydrolase 1 9.029e-48 0.38
RN5A_HUMAN RNASEL 2-5A-dependent ribonuclease 1.121e-46 0.37
Q70E71_9ENTE aac(6')-Ii Aminoglycoside N(6')-acetyltransferase 2.578e-46 0.34
ENPP1_RAT Enpp1 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 6.651e-45 0.37
G3P_HUMAN GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1.413e-44 0.33
POLG_POL1M Genome polyprotein 9.585e-44 0.35
P2RY2_RAT P2ry2 P2Y purinoceptor 2 2.2e-43 0.34
SYQ_HUMAN QARS1 Glutamine--tRNA ligase 7.963e-43 0.37
DOT1L_HUMAN DOT1L Histone-lysine N-methyltransferase, H3 lysine-79 specific 8.262e-43 0.35
BIRA_ECOLI birA Bifunctional ligase/repressor BirA 2.89e-41 0.33
KITH_RAT Tk1 Thymidine kinase, cytosolic 8.002e-41 0.34
SETD2_HUMAN SETD2 Histone-lysine N-methyltransferase SETD2 2.281e-40 0.32
PUR6_CHICK AIRC Multifunctional protein ADE2 3.6e-40 0.34
P2RX4_MOUSE P2rx4 P2X purinoceptor 4 3.334e-39 0.51
C3SIU2_ECOLX metJ Met repressor 2.237e-38 0.33
AA1R_CAVPO ADORA1 Adenosine receptor A1 4.883e-38 0.34
SIAT1_HUMAN ST6GAL1 Beta-galactoside alpha-2,6-sialyltransferase 1 1.645e-37 0.32
AA2AR_HUMAN ADORA2A Adenosine receptor A2a 2.942e-37 0.42
UBA7_HUMAN UBA7 Ubiquitin-like modifier-activating enzyme 7 5.713e-37 0.29
Q9HWG3_PSEAE pchD Pyochelin biosynthesis protein PchD 1.775e-36 0.29
MSHC_MYCTU mshC L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase 2.593e-36 0.29
Q8T6J6_PLAFA ompdc Orotidine 5'-monophosphate decarboxylase 3.875e-36 0.29
SYS_ECOLI serS Serine--tRNA ligase 5.768e-36 0.28
P2RX4_RAT P2rx4 P2X purinoceptor 4 5.627e-34 0.51
G3PG_TRYCR Glyceraldehyde-3-phosphate dehydrogenase, glycosomal 4.685e-33 0.33
PYRF_YEAST URA3 Orotidine 5'-phosphate decarboxylase 5.282e-33 0.36
IMDH2_HUMAN IMPDH2 Inosine-5'-monophosphate dehydrogenase 2 2.53e-32 0.41
DPOG1_HUMAN POLG DNA polymerase subunit gamma-1 7.37e-32 0.33
P2RY6_RAT P2ry6 P2Y purinoceptor 6 6.271e-29 0.34
AMPD1_RABIT AMPD1 AMP deaminase 1 1.715e-28 0.35
P2RX4_HUMAN P2RX4 P2X purinoceptor 4 3.04e-28 0.51
NMT_YEAST NMT1 Glycylpeptide N-tetradecanoyltransferase 4.36e-28 0.35
Q3ZDS5_9HEPC NS5B 2.89e-27 0.34
AA2AR_MOUSE Adora2a Adenosine receptor A2a 4.671e-27 0.32
SYIC_HUMAN IARS1 Isoleucine--tRNA ligase, cytoplasmic 4.93e-26 0.30
S29A1_RAT Slc29a1 Equilibrative nucleoside transporter 1 2.549e-25 0.31
RNAS1_BOVIN RNASE1 Ribonuclease pancreatic 1.578e-24 0.31
P2RX1_RAT P2rx1 P2X purinoceptor 1 1.775e-24 0.49
ANM7_HUMAN PRMT7 Protein arginine N-methyltransferase 7 2.158e-24 0.30
PARG_HUMAN PARG Poly(ADP-ribose) glycohydrolase 4.888e-24 0.39
ENPP1_HUMAN ENPP1 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 6.324e-24 0.51
UBA6_HUMAN UBA6 Ubiquitin-like modifier-activating enzyme 6 8.433e-24 0.29
AA2BR_HUMAN ADORA2B Adenosine receptor A2b 8.913e-24 0.37
PQSA_PSEAE pqsA Anthranilate--CoA ligase 1.734e-23 0.29
SYL_ECOLI leuS Leucine--tRNA ligase 1.734e-23 0.29
CYAA_BACAN cya Calmodulin-sensitive adenylate cyclase 2.586e-22 0.48
BPL1_HUMAN HLCS Biotin--protein ligase 3.935e-22 0.33
IF4E_MOUSE Eif4e Eukaryotic translation initiation factor 4E 2.94e-21 0.34
ADCY2_RAT Adcy2 Adenylate cyclase type 2 7.842e-21 0.29
P2RY1_HUMAN P2RY1 P2Y purinoceptor 1 4.727e-20 0.52
SYMC_HUMAN MARS1 Methionine--tRNA ligase, cytoplasmic 7.397e-19 0.36
PANC_MYCTU panC Pantothenate synthetase 1.466e-18 0.32
SYI_ECOLI ileS Isoleucine--tRNA ligase 3.334e-18 0.29
PLCG1_HUMAN PLCG1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 7.004e-18 0.38
O39930_9HEPC NS5b RNA-directed RNA polymerase 8.55e-18 0.34
BIP_HUMAN HSPA5 Endoplasmic reticulum chaperone BiP 2.7e-17 0.43
Q4VQ11_PIG Adenosine receptor A1 2.22e-16 0.32
AA1R_MOUSE Adora1 Adenosine receptor A1 9.992e-16 0.32
A0A0E7NXW5_STAAU birA Bifunctional ligase/repressor BirA 6.328e-15 0.33
P2RX2_RAT P2rx2 P2X purinoceptor 2 9.548e-15 0.51
RAC1_HUMAN RAC1 Ras-related C3 botulinum toxin substrate 1 1.11e-14 0.44
AA3R_MOUSE Adora3 Adenosine receptor A3 1.177e-14 0.33
P2RY2_MOUSE P2ry2 P2Y purinoceptor 2 5.496e-14 0.34
RAB7A_HUMAN RAB7A Ras-related protein Rab-7a 8.038e-14 0.44
CDC42_HUMAN CDC42 Cell division control protein 42 homolog 1.206e-13 0.44
DPOLB_HUMAN POLB DNA polymerase beta 1.386e-13 0.29
ADH1A_HUMAN ADH1A Alcohol dehydrogenase 1A 3.096e-13 0.36
ADA_BOVIN ADA Adenosine deaminase 3.656e-13 0.39
DNMT1_HUMAN DNMT1 DNA (cytosine-5)-methyltransferase 1 3.749e-13 0.33
5NTD_HUMAN NT5E 5'-nucleotidase 6.57e-13 0.36
AA2AR_CAVPO ADORA2A Adenosine receptor A2a 1.629e-12 0.31
OGT1_HUMAN OGT UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 1.689e-12 0.34
TRPM2_HUMAN TRPM2 Transient receptor potential cation channel subfamily M member 2 8.634e-12 0.29
SYTC_HUMAN TARS1 Threonine--tRNA ligase 1, cytoplasmic 2.539e-11 0.29
DPOLA_HUMAN POLA1 DNA polymerase alpha catalytic subunit 3.016e-11 0.34
M9TGV3_MYCTX inhA Enoyl-[acyl-carrier-protein] reductase [NADH] 2.77e-10 0.34
SETD7_HUMAN SETD7 Histone-lysine N-methyltransferase SETD7 3.547e-10 0.32
DCPS_HUMAN DCPS m7GpppX diphosphatase 4.002e-10 0.41
AA1R_BOVIN ADORA1 Adenosine receptor A1 5.234e-10 0.35
PARG_RAT Parg Poly(ADP-ribose) glycohydrolase 1.182e-09 0.39
PUR9_HUMAN ATIC Bifunctional purine biosynthesis protein PURH 6.712e-09 0.32
P2Y12_RAT P2ry12 P2Y purinoceptor 12 7.203e-09 0.51
HS71A_HUMAN HSPA1A Heat shock 70 kDa protein 1A 2.665e-08 0.42
5NTD_RAT Nt5e 5'-nucleotidase 2.848e-08 0.43
CPT1B_RAT Cpt1b Carnitine O-palmitoyltransferase 1, muscle isoform 5.455e-08 0.34
ENPL_CANLF HSP90B1 Endoplasmin 1.35e-07 0.42
HPRT_HUMAN HPRT1 Hypoxanthine-guanine phosphoribosyltransferase 1.387e-07 0.39
CLAT_HUMAN CHAT Choline O-acetyltransferase 7.008e-07 0.37
HSP7C_HUMAN HSPA8 Heat shock cognate 71 kDa protein 8.755e-07 0.43
Q9Y0I0_9TRYP AT1 Adenosine transporter 1 2.156e-06 0.28
TMIG3_HUMAN TMIGD3 Transmembrane domain-containing protein TMIGD3 2.443e-06 0.33
SYT_YERPE thrS Threonine--tRNA ligase 5.02e-06 0.29

Ganaxolone

GBRB2_HUMAN GABRB2 Gamma-aminobutyric acid receptor subunit beta-2 2.889e-53 1.00
GBRA1_HUMAN GABRA1 Gamma-aminobutyric acid receptor subunit alpha-1 4.658e-22 1.00
GBRG2_HUMAN GABRG2 Gamma-aminobutyric acid receptor subunit gamma-2 4.677e-19 1.00
S5A2_HUMAN SRD5A2 3-oxo-5-alpha-steroid 4-dehydrogenase 2 2.339e-145 0.46
G6PD_HUMAN G6PD Glucose-6-phosphate 1-dehydrogenase 5.04e-116 0.66
GBRD_HUMAN GABRD Gamma-aminobutyric acid receptor subunit delta 8.259e-116 0.66
S5A1_HUMAN SRD5A1 3-oxo-5-alpha-steroid 4-dehydrogenase 1 5.195e-98 0.39
CBG_HUMAN SERPINA6 Corticosteroid-binding globulin 5.547e-63 0.44
ANDR_RAT Ar Androgen receptor 5.037e-60 0.50
GBRA4_HUMAN GABRA4 Gamma-aminobutyric acid receptor subunit alpha-4 1.682e-46 0.66
NR1I3_MOUSE Nr1i3 Nuclear receptor subfamily 1 group I member 3 1.089e-41 0.35
TAT_HV112 tat Protein Tat 1.255e-41 0.31
S22A3_RAT Slc22a3 Solute carrier family 22 member 3 3.13e-40 0.37
SHBG_HUMAN SHBG Sex hormone-binding globulin 3.434e-40 0.46
3BHS1_HUMAN HSD3B1 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 1.98e-38 0.31
SMT1_ARATH SMT1 Cycloartenol-C-24-methyltransferase 3.653e-38 0.31
GBRG1_RAT Gabrg1 Gamma-aminobutyric acid receptor subunit gamma-1 7.195e-37 0.58
DHB3_HUMAN HSD17B3 Testosterone 17-beta-dehydrogenase 3 2.123e-35 0.43
SHBG_RAT Shbg Sex hormone-binding globulin 1.547e-32 0.40
MRP4_HUMAN ABCC4 Multidrug resistance-associated protein 4 3.565e-30 0.33
Q9GRG7_9TRYP g6pd Glucose-6-phosphate 1-dehydrogenase 6.531e-30 0.37
GBRA4_RAT Gabra4 Gamma-aminobutyric acid receptor subunit alpha-4 6.939e-30 0.40
DHB3_RAT Hsd17b3 Testosterone 17-beta-dehydrogenase 3 1.677e-29 0.37
S22A2_RAT Slc22a2 Solute carrier family 22 member 2 1.51e-26 0.46
NMDE3_HUMAN GRIN2C Glutamate receptor ionotropic, NMDA 2C 2.07e-23 0.38
GABR1_RAT Gabbr1 Gamma-aminobutyric acid type B receptor subunit 1 4.675e-21 0.66
SO1A1_RAT Slco1a1 Solute carrier organic anion transporter family member 1A1 1.26e-20 0.33
NMDE4_HUMAN GRIN2D Glutamate receptor ionotropic, NMDA 2D 1.575e-19 0.38
GPBAR_HUMAN GPBAR1 G-protein coupled bile acid receptor 1 1.172e-17 0.62
Q690N0_BOVIN PGR Progesterone receptor 1.11e-16 0.46
SIA4B_RAT St3gal2 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 1.11e-16 0.32
DHI2_HUMAN HSD11B2 Corticosteroid 11-beta-dehydrogenase isozyme 2 8.882e-16 0.38
NMDE2_HUMAN GRIN2B Glutamate receptor ionotropic, NMDA 2B 1.11e-15 0.45
NMDZ1_HUMAN GRIN1 Glutamate receptor ionotropic, NMDA 1 1.11e-15 0.45
S22A3_HUMAN SLC22A3 Solute carrier family 22 member 3 2.776e-15 0.46
REST_BORBU resT Telomere resolvase ResT 4.441e-15 0.37
AT12A_HUMAN ATP12A Potassium-transporting ATPase alpha chain 2 7.994e-15 0.29
FABPL_RAT Fabp1 Fatty acid-binding protein, liver 2.265e-14 0.46
ERG2_YEAST ERG2 C-8 sterol isomerase 2.102e-13 0.46
EPHA2_MOUSE Epha2 Ephrin type-A receptor 2 5.245e-13 0.32
ANDR_MOUSE Ar Androgen receptor 2.088e-12 0.46
GBRB3_HUMAN GABRB3 Gamma-aminobutyric acid receptor subunit beta-3 8.169e-11 0.66
S22A1_HUMAN SLC22A1 Solute carrier family 22 member 1 1.02e-10 0.46
S5A1_RAT Srd5a1 3-oxo-5-alpha-steroid 4-dehydrogenase 1 2.422e-10 0.37
AT1A1_CANLF ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 3.611e-09 0.30
PRGR_RABIT PGR Progesterone receptor 3.744e-09 0.46
LICH_HUMAN LIPA Lysosomal acid lipase/cholesteryl ester hydrolase 4.237e-09 0.32
DPOLB_RAT Polb DNA polymerase beta 1.42e-07 0.37
S5A2_RAT Srd5a2 3-oxo-5-alpha-steroid 4-dehydrogenase 2 1.52e-07 0.37
MCR_RAT Nr3c2 Mineralocorticoid receptor 1.262e-06 0.40

Lacosamide

SCN3A_RAT Scn3a Sodium channel protein type 3 subunit alpha 1.089e-50 1.00
CAH2_HUMAN CA2 Carbonic anhydrase 2 8.633e-12 1.00
CAH3_HUMAN CA3 Carbonic anhydrase 3 3.781e-11 1.00
CAH7_HUMAN CA7 Carbonic anhydrase 7 4.001e-11 1.00
CAH5A_HUMAN CA5A Carbonic anhydrase 5A, mitochondrial 4.791e-11 1.00
CAH1_HUMAN CA1 Carbonic anhydrase 1 3.698e-10 1.00
CAH4_HUMAN CA4 Carbonic anhydrase 4 3.849e-10 1.00
CAH14_HUMAN CA14 Carbonic anhydrase 14 1.288e-09 1.00
CAH5B_HUMAN CA5B Carbonic anhydrase 5B, mitochondrial 3.293e-08 1.00
CAH15_MOUSE Ca15 Carbonic anhydrase 15 6.422e-08 1.00
CAH12_HUMAN CA12 Carbonic anhydrase 12 9.097e-07 1.00
CAH9_HUMAN CA9 Carbonic anhydrase 9 1.91e-06 1.00
CAH13_HUMAN CA13 Carbonic anhydrase 13 1.439e-05 1.00
CAH6_HUMAN CA6 Carbonic anhydrase 6 1.993e-05 1.00
SCN9A_HUMAN SCN9A Sodium channel protein type 9 subunit alpha 0.0377 1.00
CAN2_HUMAN CAPN2 Calpain-2 catalytic subunit 4.176e-147 0.40
CAN1_HUMAN CAPN1 Calpain-1 catalytic subunit 7.941e-133 0.48
NEP_RABIT MME Neprilysin 3.149e-129 0.39
CATL1_BOVIN CTSL Cathepsin L1 1.129e-128 0.58
THER_BACTH npr Thermolysin 3.066e-117 0.37
MMP9_RAT Mmp9 Matrix metalloproteinase-9 5.352e-115 0.45
CATB_BOVIN CTSB Cathepsin B 3.898e-110 0.40
TIMP3_RAT Timp3 Metalloproteinase inhibitor 3 7.609e-110 0.45
PAPA1_CARPA Papain 8.702e-110 0.58
AMPN_PIG ANPEP Aminopeptidase N 9.707e-106 0.48
FURIN_HUMAN FURIN Furin 6.159e-103 0.39
KLKB1_HUMAN KLKB1 Plasma kallikrein 6.741e-103 0.46
AMD_RAT Pam Peptidylglycine alpha-amidating monooxygenase 7.413e-97 0.37
ACE2_HUMAN ACE2 Angiotensin-converting enzyme 2 7.389e-96 0.38
TF2AA_HUMAN GTF2A1 Transcription initiation factor IIA subunit 1 8.982e-94 0.33
AMP1_PLAFQ M1 family aminopeptidase 1.58e-93 0.46
TRY1_RAT Prss1 Anionic trypsin-1 7.289e-92 0.41
UPAR_RAT Plaur Urokinase plasminogen activator surface receptor 7.289e-92 0.41
NEP_RAT Mme Neprilysin 2.39e-91 0.42
PDS_SYNE7 pds 15-cis-phytoene desaturase 1.448e-86 0.43
FCER2_HUMAN FCER2 Low affinity immunoglobulin epsilon Fc receptor 4.5e-80 0.47
CPNS1_PIG CAPNS1 Calpain small subunit 1 7.446e-80 0.34
CATB_HUMAN CTSB Cathepsin B 7.817e-78 0.42
NEP_MOUSE Mme Neprilysin 1.217e-77 0.38
KLK1_HUMAN KLK1 Kallikrein-1 3.288e-77 0.46
PTPRA_HUMAN PTPRA Receptor-type tyrosine-protein phosphatase alpha 1.203e-73 0.36
CBPA1_HUMAN CPA1 Carboxypeptidase A1 9.257e-72 0.37
S6A12_MOUSE Slc6a12 Sodium- and chloride-dependent betaine transporter 8.472e-71 0.43
CATL1_HUMAN CTSL Cathepsin L1 9.074e-71 0.44
NEP_HUMAN MME Neprilysin 2.276e-66 0.37
CAN2_BOVIN CAPN2 Calpain-2 catalytic subunit 3.231e-66 0.37
PROC_HUMAN PROC Vitamin K-dependent protein C 5.521e-66 0.41
CATJ_RAT Ctsj Cathepsin J 1.829e-65 0.40
CATH_RAT Ctsh Pro-cathepsin H 3.764e-65 0.40
ACE_MOUSE Ace Angiotensin-converting enzyme 8.34e-64 0.35
THRB_RAT F2 Prothrombin 1.933e-63 0.41
MC5R_MOUSE Mc5r Melanocortin receptor 5 3.226e-63 0.37
TETX_CLOTE tetX Tetanus toxin 1.588e-62 0.30
PLMN_RAT Plg Plasminogen 7.671e-62 0.41
MC4R_MOUSE Mc4r Melanocortin receptor 4 1.032e-61 0.37
Q6DMN0_TOXGO CPL Cathepsin L 1.9e-60 0.38
PP2AA_BOVIN PPP2CA Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 1.417e-59 0.37
FPR1_HUMAN FPR1 fMet-Leu-Phe receptor 4.758e-58 0.37
PCSK6_HUMAN PCSK6 Proprotein convertase subtilisin/kexin type 6 1.281e-57 0.39
LAT1_HUMAN SLC7A5 Large neutral amino acids transporter small subunit 1 3.661e-57 0.34
MMP8_RAT Mmp8 Neutrophil collagenase 4.497e-56 0.32
CATL2_HUMAN CTSV Cathepsin L2 4.791e-56 0.38
NPY4R_HUMAN NPY4R Neuropeptide Y receptor type 4 3.448e-55 0.33
CATK_HUMAN CTSK Cathepsin K 1.174e-54 0.58
S15A1_HUMAN SLC15A1 Solute carrier family 15 member 1 1.308e-54 0.38
CATC_RAT Ctsc Dipeptidyl peptidase 1 2.249e-54 0.40
RIR1_MOUSE Rrm1 Ribonucleoside-diphosphate reductase large subunit 5.272e-54 0.35
MSHR_MOUSE Mc1r Melanocyte-stimulating hormone receptor 5.415e-54 0.37
CATZ_RAT Ctsz Cathepsin Z 5.751e-54 0.34
EDNRA_MOUSE Ednra Endothelin-1 receptor 7.494e-54 0.35
CATB_RAT Ctsb Cathepsin B 1.114e-53 0.40
MC3R_MOUSE Mc3r Melanocortin receptor 3 2.067e-53 0.37
MMP3_HUMAN MMP3 Stromelysin-1 2.639e-52 0.42
MMP1_HUMAN MMP1 Interstitial collagenase 4.119e-51 0.47
MTR1B_HUMAN MTNR1B Melatonin receptor type 1B 2.067e-50 0.43
ACE_HUMAN ACE Angiotensin-converting enzyme 1.027e-49 0.37
PSB5_HUMAN PSMB5 Proteasome subunit beta type-5 2.037e-49 0.53
AMPB_RAT Rnpep Aminopeptidase B 1.507e-48 0.34
CATS_HUMAN CTSS Cathepsin S 4.611e-48 0.58
NK1R_RAT Tacr1 Substance-P receptor 7.853e-48 0.49
AMPN_MOUSE Anpep Aminopeptidase N 1.582e-47 0.38
Q72874_9HIV1 pol Pol polyprotein 2.033e-47 0.41
MRGX1_MOUSE Mrgprx1 Mas-related G-protein coupled receptor member X1 5.968e-47 0.32
NEC1_HUMAN PCSK1 Neuroendocrine convertase 1 7.749e-47 0.39
PCSK5_HUMAN PCSK5 Proprotein convertase subtilisin/kexin type 5 7.749e-47 0.39
SMS1_HUMAN SGMS1 Phosphatidylcholine:ceramide cholinephosphotransferase 1 3.88e-46 0.33
PADI6_HUMAN PADI6 Protein-arginine deiminase type-6 5.508e-46 0.38
FA12_HUMAN F12 Coagulation factor XII 6.206e-46 0.33
NEC2_HUMAN PCSK2 Neuroendocrine convertase 2 1.083e-45 0.39
MTR1A_HUMAN MTNR1A Melatonin receptor type 1A 1.78e-45 0.39
Q99P97_RAT Histone deacetylase 6 4.068e-45 0.36
AMD_HUMAN PAM Peptidyl-glycine alpha-amidating monooxygenase 4.275e-45 0.49
BRCA1_HUMAN BRCA1 Breast cancer type 1 susceptibility protein 1.007e-43 0.32
GNPAT_HUMAN GNPAT Dihydroxyacetone phosphate acyltransferase 1.165e-43 0.42
POLG_HRV14 Genome polyprotein 2.679e-43 0.34
AMPB_MOUSE Rnpep Aminopeptidase B 8.654e-43 0.34
AMPL_BOVIN LAP3 Cytosol aminopeptidase 8.654e-43 0.34
PSB8_HUMAN PSMB8 Proteasome subunit beta type-8 3.14e-42 0.41
VM1B1_BOTAS Snake venom metalloproteinase BaP1 1.613e-41 0.36
PSB5_YEAST PRE2 Proteasome subunit beta type-5 4.426e-41 0.36
CHIA_SERMA chiA Chitinase A 1.09e-40 0.34
PLMN_BOVIN PLG Plasminogen 4.704e-40 0.34
AMPN_HUMAN ANPEP Aminopeptidase N 1.119e-39 0.48
CYSP_TRYCR Cruzipain 1.284e-39 0.43
CBPA1_BOVIN CPA1 Carboxypeptidase A1 1.95e-39 0.39
CANX_CHICK Calpain-1 catalytic subunit 3.543e-39 0.31
NEP_PIG MME Neprilysin 2.032e-38 0.31
PEPT1_DERPT DERP1 Peptidase 1 4.153e-38 0.37
GLUT4_HUMAN SLC2A4 Solute carrier family 2, facilitated glucose transporter member 4 4.999e-38 0.31
CBPA3_HUMAN CPA3 Mast cell carboxypeptidase A 2.25e-37 0.32
ACACB_HUMAN ACACB Acetyl-CoA carboxylase 2 2.392e-37 0.43
Q8ILP4_PLAF7 Pantothenate kinase, putative 4.749e-37 0.29
GLT_PYRHO Glutamate transporter homolog 7.142e-37 0.29
EDNRB_RAT Ednrb Endothelin receptor type B 1.363e-36 0.35
CASP1_HUMAN CASP1 Caspase-1 2.401e-36 0.37
Q95PM0_TRYBR rhodesain Cysteine protease 2.494e-36 0.36
NPFF1_HUMAN NPFFR1 Neuropeptide FF receptor 1 5.007e-36 0.37
CAN1_PIG CAPN1 Calpain-1 catalytic subunit 6.089e-36 0.36
S6A11_MOUSE Slc6a11 Sodium- and chloride-dependent GABA transporter 3 6.471e-36 0.33
NK3R_CAVPO TACR3 Neuromedin-K receptor 1.379e-34 0.35
NK3R_HUMAN TACR3 Neuromedin-K receptor 2.782e-34 0.41
CATK_RABIT CTSK Cathepsin K 3.54e-34 0.42
DNPEP_HUMAN DNPEP Aspartyl aminopeptidase 1.972e-33 0.33
PCSK7_HUMAN PCSK7 Proprotein convertase subtilisin/kexin type 7 6.158e-33 0.39
GP139_HUMAN GPR139 Probable G-protein coupled receptor 139 2.287e-32 0.33
NPY1R_HUMAN NPY1R Neuropeptide Y receptor type 1 2.515e-32 0.43
MMP2_HUMAN MMP2 72 kDa type IV collagenase 9.506e-32 0.46
VE1_HPV11 E1 Replication protein E1 3.273e-31 0.36
MMP12_MOUSE Mmp12 Macrophage metalloelastase 1.103e-30 0.31
NPFF2_HUMAN NPFFR2 Neuropeptide FF receptor 2 1.374e-30 0.37
Q4U254_9ENTO protease Protease 2.551e-30 0.39
S15A2_RAT Slc15a2 Solute carrier family 15 member 2 6.781e-30 0.37
MMP8_HUMAN MMP8 Neutrophil collagenase 6.927e-30 0.45
NK2R_MESAU TACR2 Substance-K receptor 9.067e-30 0.35
ACE_RAT Ace Angiotensin-converting enzyme 2.335e-29 0.36
NAAA_RAT Naaa N-acylethanolamine-hydrolyzing acid amidase 3.833e-29 0.31
BRS3_HUMAN BRS3 Bombesin receptor subtype-3 1.41e-28 0.38
UBC9_HUMAN UBE2I SUMO-conjugating enzyme UBC9 2.168e-28 0.36
MMP9_HUMAN MMP9 Matrix metalloproteinase-9 2.563e-28 0.41
PPID_HUMAN PPID Peptidyl-prolyl cis-trans isomerase D 3.637e-28 0.33
CARM1_HUMAN CARM1 Histone-arginine methyltransferase CARM1 8.554e-28 0.34
S22A6_RAT Slc22a6 Solute carrier family 22 member 6 1.292e-27 0.50
ACE2_RAT Ace2 Angiotensin-converting enzyme 2 1.837e-27 0.32
PPAP_HUMAN ACP3 Prostatic acid phosphatase 3.047e-27 0.38
ECE1_RAT Ece1 Endothelin-converting enzyme 1 1.035e-26 0.35
CAC1I_HUMAN CACNA1I Voltage-dependent T-type calcium channel subunit alpha-1I 1.094e-26 0.32
PTN1_HUMAN PTPN1 Tyrosine-protein phosphatase non-receptor type 1 1.884e-26 0.47
PSB9_HUMAN PSMB9 Proteasome subunit beta type-9 2.092e-26 0.36
CTRB1_HUMAN CTRB1 Chymotrypsinogen B 3.072e-26 0.33
CASP3_HUMAN CASP3 Caspase-3 4.017e-26 0.45
TRXR1_HUMAN TXNRD1 Thioredoxin reductase 1, cytoplasmic 4.439e-26 0.33
NMBR_HUMAN NMBR Neuromedin-B receptor 5.588e-26 0.37
Q94F81_MAIZE hda106 HD2 type histone deacetylase HDA106 2.543e-25 0.46
PEPA1_PENJA Penicillopepsin-1 2.922e-25 0.28
Q3HTL5_PLAFA fp2B Falcipain 2B 3.332e-25 0.31
Q79MP6_PSEAI blaIMP-1 Beta-lactamase 4.47e-25 0.32
PSA1_HUMAN PSMA1 Proteasome subunit alpha type-1 9.776e-25 0.36
PSA2_HUMAN PSMA2 Proteasome subunit alpha type-2 9.776e-25 0.36
PSA3_HUMAN PSMA3 Proteasome subunit alpha type-3 9.776e-25 0.36
PSA4_HUMAN PSMA4 Proteasome subunit alpha type-4 9.776e-25 0.36
PSA5_HUMAN PSMA5 Proteasome subunit alpha type-5 9.776e-25 0.36
PSA6_HUMAN PSMA6 Proteasome subunit alpha type-6 9.776e-25 0.36
PSA7_HUMAN PSMA7 Proteasome subunit alpha type-7 9.776e-25 0.36
PSB11_HUMAN PSMB11 Proteasome subunit beta type-11 9.776e-25 0.36
PSB3_HUMAN PSMB3 Proteasome subunit beta type-3 9.776e-25 0.36
PSB4_HUMAN PSMB4 Proteasome subunit beta type-4 9.776e-25 0.36
PSB6_HUMAN PSMB6 Proteasome subunit beta type-6 9.776e-25 0.36
PSB7_HUMAN PSMB7 Proteasome subunit beta type-7 9.776e-25 0.36
PSMA8_HUMAN PSMA8 Proteasome subunit alpha-type 8 9.776e-25 0.36
BLA1_STEMA Metallo-beta-lactamase L1 type 3 1.535e-24 0.31
Q9NBD4_PLAFA Cysteine protease falcipain-2 1.62e-24 0.30
SUMO1_HUMAN SUMO1 Small ubiquitin-related modifier 1 1.62e-24 0.30
CASP1_MOUSE Casp1 Caspase-1 1.777e-24 0.36
HDAC1_RAT Hdac1 Histone deacetylase 1 2.683e-24 0.32
CASP8_HUMAN CASP8 Caspase-8 3.053e-24 0.36
PSB10_HUMAN PSMB10 Proteasome subunit beta type-10 6.009e-24 0.36
KLK5_HUMAN KLK5 Kallikrein-5 1.081e-23 0.31
Q704V1_PSEAI blaGIM-1 GIM-1 protein 1.734e-23 0.29
1433S_HUMAN SFN 14-3-3 protein sigma 2.847e-23 0.29
Q9FD53_STREE mvaD Diphosphomevalonate decarboxylase 7.467e-23 0.33
OPRM_RAT Oprm1 Mu-type opioid receptor 7.928e-23 0.40
CBX7_HUMAN CBX7 Chromobox protein homolog 7 2.405e-22 0.32
RIR1_MYCTU nrdE Ribonucleoside-diphosphate reductase subunit alpha 3.88e-22 0.35
ACE_RABIT ACE Angiotensin-converting enzyme 5.645e-22 0.35
PPIB_HUMAN PPIB Peptidyl-prolyl cis-trans isomerase B 6.474e-22 0.32
AMPB_HUMAN RNPEP Aminopeptidase B 6.765e-22 0.33
CATD_HUMAN CTSD Cathepsin D 8.423e-22 0.46
SIR3_HUMAN SIRT3 NAD-dependent protein deacetylase sirtuin-3, mitochondrial 1.058e-21 0.39
SYYC_HUMAN YARS1 Tyrosine--tRNA ligase, cytoplasmic 1.406e-21 0.32
Q6RY99_RAT Tetraspanin 2.385e-21 0.30
LCAP_RAT Lnpep Leucyl-cystinyl aminopeptidase 2.784e-21 0.34
ACOD1_MOUSE Scd1 Acyl-CoA desaturase 1 4.197e-21 0.33
RENI_HUMAN REN Renin 4.381e-21 0.39
CTRA_BOVIN Chymotrypsinogen A 5.425e-21 0.39
ADRM1_HUMAN ADRM1 Proteasomal ubiquitin receptor ADRM1 6.621e-21 0.36
PRS10_HUMAN PSMC6 26S proteasome regulatory subunit 10B 6.621e-21 0.36
PRS4_HUMAN PSMC1 26S proteasome regulatory subunit 4 6.621e-21 0.36
PRS6A_HUMAN PSMC3 26S proteasome regulatory subunit 6A 6.621e-21 0.36
PRS6B_HUMAN PSMC4 26S proteasome regulatory subunit 6B 6.621e-21 0.36
PRS7_HUMAN PSMC2 26S proteasome regulatory subunit 7 6.621e-21 0.36
PRS8_HUMAN PSMC5 26S proteasome regulatory subunit 8 6.621e-21 0.36
PSD11_HUMAN PSMD11 26S proteasome non-ATPase regulatory subunit 11 6.621e-21 0.36
PSD12_HUMAN PSMD12 26S proteasome non-ATPase regulatory subunit 12 6.621e-21 0.36
PSD13_HUMAN PSMD13 26S proteasome non-ATPase regulatory subunit 13 6.621e-21 0.36
PSMD1_HUMAN PSMD1 26S proteasome non-ATPase regulatory subunit 1 6.621e-21 0.36
PSMD2_HUMAN PSMD2 26S proteasome non-ATPase regulatory subunit 2 6.621e-21 0.36
PSMD3_HUMAN PSMD3 26S proteasome non-ATPase regulatory subunit 3 6.621e-21 0.36
PSMD4_HUMAN PSMD4 26S proteasome non-ATPase regulatory subunit 4 6.621e-21 0.36
PSMD6_HUMAN PSMD6 26S proteasome non-ATPase regulatory subunit 6 6.621e-21 0.36
PSMD7_HUMAN PSMD7 26S proteasome non-ATPase regulatory subunit 7 6.621e-21 0.36
PSMD8_HUMAN PSMD8 26S proteasome non-ATPase regulatory subunit 8 6.621e-21 0.36
SEM1_HUMAN SEM1 26S proteasome complex subunit SEM1 6.621e-21 0.36
CATH_HUMAN CTSH Pro-cathepsin H 6.638e-21 0.31
PTN2_HUMAN PTPN2 Tyrosine-protein phosphatase non-receptor type 2 9.291e-21 0.44
CMA1_HUMAN CMA1 Chymase 1.181e-20 0.34
PSB2_HUMAN PSMB2 Proteasome subunit beta type-2 1.527e-20 0.36
OPRD_RAT Oprd1 Delta-type opioid receptor 1.944e-20 0.37
PPM1B_HUMAN PPM1B Protein phosphatase 1B 2.407e-20 0.37
Q9NAW4_PLAFA Cysteine protease falcipain-3 2.598e-20 0.32
SIR1_HUMAN SIRT1 NAD-dependent protein deacetylase sirtuin-1 3.213e-20 0.39
NK2R_HUMAN TACR2 Substance-K receptor 3.982e-20 0.33
PADI1_HUMAN PADI1 Protein-arginine deiminase type-1 1.052e-19 0.30
PADI3_HUMAN PADI3 Protein-arginine deiminase type-3 1.052e-19 0.30
CAN2_PIG CAPN2 Calpain-2 catalytic subunit 1.144e-19 0.37
SC6A3_MACFA SLC6A3 Sodium-dependent dopamine transporter 1.34e-19 0.29
A0A0C7ACN7_PSEAI pqsD 3-oxoacyl-ACP synthase 1.492e-19 0.31
TGM2_MOUSE Tgm2 Protein-glutamine gamma-glutamyltransferase 2 1.985e-19 0.31
FA7_HUMAN F7 Coagulation factor VII 4.404e-19 0.38
PSB1_HUMAN PSMB1 Proteasome subunit beta type-1 7.062e-19 0.36
OPRM_CAVPO OPRM1 Mu-type opioid receptor 7.919e-19 0.37
CAC1G_HUMAN CACNA1G Voltage-dependent T-type calcium channel subunit alpha-1G 3.008e-18 0.33
ASAH1_HUMAN ASAH1 Acid ceramidase 3.417e-18 0.33
Q9N6S8_PLAFA Cysteine proteinase falcipain 2a 4.827e-18 0.36
HEXA_HUMAN HEXA Beta-hexosaminidase subunit alpha 9.056e-18 0.28
SPSB2_HUMAN SPSB2 SPRY domain-containing SOCS box protein 2 9.771e-18 0.28
NALD2_HUMAN NAALAD2 N-acetylated-alpha-linked acidic dipeptidase 2 9.864e-18 0.33
SENP1_HUMAN SENP1 Sentrin-specific protease 1 1.047e-17 0.30
TPA_HUMAN PLAT Tissue-type plasminogen activator 1.139e-17 0.37
PTPRB_HUMAN PTPRB Receptor-type tyrosine-protein phosphatase beta 1.515e-17 0.33
BMP1_HUMAN BMP1 Bone morphogenetic protein 1 2.223e-17 0.36
GRB2_HUMAN GRB2 Growth factor receptor-bound protein 2 2.571e-17 0.31
Q8CGM4_CAVPO OPRM1 Mu-opioid receptor 2.634e-17 0.33
ACACA_HUMAN ACACA Acetyl-CoA carboxylase 1 3.619e-17 0.38
PLMN_HUMAN PLG Plasminogen 3.645e-17 0.42
TS1R1_HUMAN TAS1R1 Taste receptor type 1 member 1 3.854e-17 0.30
CASP9_HUMAN CASP9 Caspase-9 4.768e-17 0.32
PEPA_PIG PGA Pepsin A 5.203e-17 0.30
BACE1_HUMAN BACE1 Beta-secretase 1 1.11e-16 0.39
C1S_HUMAN C1S Complement C1s subcomponent 1.11e-16 0.31
CAC1H_HUMAN CACNA1H Voltage-dependent T-type calcium channel subunit alpha-1H 1.11e-16 0.32
LY96_HUMAN LY96 Lymphocyte antigen 96 1.11e-16 0.32
MRGX1_RAT Mrgprx1 Mas-related G-protein coupled receptor member X1 1.11e-16 0.32
FA11_HUMAN F11 Coagulation factor XI 2.22e-16 0.33
GRPR_MOUSE Grpr Gastrin-releasing peptide receptor 2.22e-16 0.33
ECE1_HUMAN ECE1 Endothelin-converting enzyme 1 3.331e-16 0.38
CEL2A_PIG CELA2A Chymotrypsin-like elastase family member 2A 6.661e-16 0.33
AMPL_HUMAN LAP3 Cytosol aminopeptidase 7.772e-16 0.33
SCYD_MAGO7 SDH1 Scytalone dehydratase 7.772e-16 0.32
SOAT1_RAT Soat1 Sterol O-acyltransferase 1 1.11e-15 0.36
Q6MGC4_RAT Pfdn6 H2-K region expressed gene 2, rat orthologue 1.221e-15 0.31
OST48_HUMAN DDOST Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit 1.665e-15 0.32
INHBA_MOUSE Inhba Inhibin beta A chain 1.887e-15 0.29
KYNU_HUMAN KYNU Kynureninase 1.887e-15 0.34
CHIB_SERMA chiB Chitinase B 1.998e-15 0.34
IL1B_HUMAN IL1B Interleukin-1 beta 2.109e-15 0.29
EAA4_RAT Slc1a6 Excitatory amino acid transporter 4 2.22e-15 0.29
GPR88_HUMAN GPR88 Probable G-protein coupled receptor 88 2.331e-15 0.33
NCOR2_HUMAN NCOR2 Nuclear receptor corepressor 2 4.663e-15 0.35
ERCC1_HUMAN ERCC1 DNA excision repair protein ERCC-1 7.883e-15 0.38
XPF_HUMAN ERCC4 DNA repair endonuclease XPF 7.883e-15 0.38
PD1L1_HUMAN CD274 Programmed cell death 1 ligand 1 8.993e-15 0.31
HDAC1_HUMAN HDAC1 Histone deacetylase 1 9.326e-15 0.44
CAC1B_HUMAN CACNA1B Voltage-dependent N-type calcium channel subunit alpha-1B 1.11e-14 0.38
CFAB_HUMAN CFB Complement factor B 1.155e-14 0.31
THRB_HUMAN F2 Prothrombin 1.454e-14 0.42
TRY1_HUMAN PRSS1 Trypsin-1 1.787e-14 0.42
LKHA4_HUMAN LTA4H Leukotriene A-4 hydrolase 1.943e-14 0.35
KLK3_HUMAN KLK3 Prostate-specific antigen 2.01e-14 0.31
HDAC8_HUMAN HDAC8 Histone deacetylase 8 2.165e-14 0.45
MMP7_HUMAN MMP7 Matrilysin 3.02e-14 0.33
ADH1G_HUMAN ADH1C Alcohol dehydrogenase 1C 3.375e-14 0.35
PPARA_HUMAN PPARA Peroxisome proliferator-activated receptor alpha 3.575e-14 0.37
PPARG_HUMAN PPARG Peroxisome proliferator-activated receptor gamma 4.075e-14 0.37
FOLH1_HUMAN FOLH1 Glutamate carboxypeptidase 2 4.441e-14 0.35
SCN2A_HUMAN SCN2A Sodium channel protein type 2 subunit alpha 5.218e-14 0.38
ENV_HV1H2 env Envelope glycoprotein gp160 5.862e-14 0.30
CASP7_HUMAN CASP7 Caspase-7 6.006e-14 0.33
HYES_HUMAN EPHX2 Bifunctional epoxide hydrolase 2 6.284e-14 0.38
AMPX_VIBPR Bacterial leucyl aminopeptidase 8.415e-14 0.34
SCN2A_RAT Scn2a Sodium channel protein type 2 subunit alpha 8.549e-14 0.33
MMEL1_HUMAN MMEL1 Membrane metallo-endopeptidase-like 1 1.141e-13 0.35
OPRD_MOUSE Oprd1 Delta-type opioid receptor 1.757e-13 0.37
BODG_PSESK Gamma-butyrobetaine dioxygenase 1.884e-13 0.29
NK1R_CAVPO TACR1 Substance-P receptor 2.089e-13 0.35
PADI4_HUMAN PADI4 Protein-arginine deiminase type-4 2.742e-13 0.30
OPRK_RAT Oprk1 Kappa-type opioid receptor 3.072e-13 0.33
KEAP1_HUMAN KEAP1 Kelch-like ECH-associated protein 1 3.921e-13 0.34
KDM1A_HUMAN KDM1A Lysine-specific histone demethylase 1A 4.474e-13 0.42
CP2CJ_HUMAN CYP2C19 Cytochrome P450 2C19 4.985e-13 0.42
ATS5_HUMAN ADAMTS5 A disintegrin and metalloproteinase with thrombospondin motifs 5 5.604e-13 0.35
MAGI3_HUMAN MAGI3 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 5.641e-13 0.28
MTR1C_XENLA mtnr1c Melatonin receptor type 1C 5.699e-13 0.31
EDNRA_HUMAN EDNRA Endothelin-1 receptor 6.375e-13 0.37
FOLH1_RAT Folh1 Glutamate carboxypeptidase 2 8.239e-13 0.33
CHLE_HUMAN BCHE Cholinesterase 1.164e-12 0.40
ENPP2_MOUSE Enpp2 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 1.486e-12 0.29
AOFA_BOVIN MAOA Amine oxidase [flavin-containing] A 2.258e-12 0.40
TRYB1_HUMAN TPSAB1 Tryptase alpha/beta-1 2.272e-12 0.37
Q9K2N0_PSEAI blaVIM-2 Beta-lactamase class B VIM-2 2.775e-12 0.31
HDAC2_HUMAN HDAC2 Histone deacetylase 2 2.86e-12 0.39
GRIA1_HUMAN GRIA1 Glutamate receptor 1 3.223e-12 0.36
MMP13_HUMAN MMP13 Collagenase 3 4.316e-12 0.40
DLG4_HUMAN DLG4 Disks large homolog 4 4.79e-12 0.32
NK3R_RAT Tacr3 Neuromedin-K receptor 5.849e-12 0.31
CARM1_MOUSE Carm1 Histone-arginine methyltransferase CARM1 8.727e-12 0.32
Q05BA5_MOUSE Ncoa3 Nuclear receptor coactivator 9.7e-12 0.29
ACOD_HUMAN SCD Acyl-CoA desaturase 1.07e-11 0.33
TPH1_HUMAN TPH1 Tryptophan 5-hydroxylase 1 1.21e-11 0.34
RS27_HUMAN RPS27 40S ribosomal protein S27 2.119e-11 0.31
CASP6_HUMAN CASP6 Caspase-6 2.265e-11 0.36
TM11D_HUMAN TMPRSS11D Transmembrane protease serine 11D 2.479e-11 0.39
NAAA_HUMAN NAAA N-acylethanolamine-hydrolyzing acid amidase 3.079e-11 0.30
SO2A1_RAT Slco2a1 Solute carrier organic anion transporter family member 2A1 3.28e-11 0.31
A5H660_SCHMA HDAC8 Histone deacetylase 8 3.615e-11 0.36
FNTA_BOVIN FNTA Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha 3.79e-11 0.43
NK1R_HUMAN TACR1 Substance-P receptor 4.046e-11 0.40
BKRB2_RAT Bdkrb2 B2 bradykinin receptor 4.404e-11 0.31
ADH1B_HUMAN ADH1B All-trans-retinol dehydrogenase [NAD(+)] ADH1B 4.673e-11 0.35
LCAP_HUMAN LNPEP Leucyl-cystinyl aminopeptidase 5.49e-11 0.29
CATG_HUMAN CTSG Cathepsin G 5.7e-11 0.33
CP3A4_HUMAN CYP3A4 Cytochrome P450 3A4 6.484e-11 0.40
SC6A1_MOUSE Slc6a1 Sodium- and chloride-dependent GABA transporter 1 1.166e-10 0.36
HYEP_HUMAN EPHX1 Epoxide hydrolase 1 1.28e-10 0.40
SIR2_HUMAN SIRT2 NAD-dependent protein deacetylase sirtuin-2 1.298e-10 0.39
SC6A3_BOVIN SLC6A3 Sodium-dependent dopamine transporter 1.369e-10 0.31
MC3R_HUMAN MC3R Melanocortin receptor 3 1.645e-10 0.32
PPCE_PIG PREP Prolyl endopeptidase 2.51e-10 0.33
PPIG_HUMAN PPIG Peptidyl-prolyl cis-trans isomerase G 3.092e-10 0.32
MC4R_HUMAN MC4R Melanocortin receptor 4 3.201e-10 0.38
UROK_HUMAN PLAU Urokinase-type plasminogen activator 3.998e-10 0.42
CP2C9_HUMAN CYP2C9 Cytochrome P450 2C9 4.058e-10 0.40
FA10_HUMAN F10 Coagulation factor X 4.38e-10 0.42
PADI2_HUMAN PADI2 Protein-arginine deiminase type-2 4.398e-10 0.29
HDAC6_HUMAN HDAC6 Histone deacetylase 6 4.72e-10 0.39
HGFA_HUMAN HGFAC Hepatocyte growth factor activator 4.769e-10 0.30
MTP_HUMAN MTTP Microsomal triglyceride transfer protein large subunit 5.27e-10 0.33
C3AR_HUMAN C3AR1 C3a anaphylatoxin chemotactic receptor 5.306e-10 0.33
ST14_MOUSE St14 Suppressor of tumorigenicity 14 protein homolog 5.575e-10 0.29
WDR5_HUMAN WDR5 WD repeat-containing protein 5 6.625e-10 0.47
PSDE_HUMAN PSMD14 26S proteasome non-ATPase regulatory subunit 14 7.588e-10 0.36
DPOL_HHV6U U38 DNA polymerase catalytic subunit 7.909e-10 0.35
ELAS_PSEAE lasB Elastase 7.941e-10 0.34
CARP_RHICH Rhizopuspepsin 8.149e-10 0.31
MCA2_TRYBB MCA2 Metacaspase 8.972e-10 0.28
SPP2A_HUMAN SPPL2A Signal peptide peptidase-like 2A 9.827e-10 0.39
OPRD_HUMAN OPRD1 Delta-type opioid receptor 1.063e-09 0.42
ITA4_HUMAN ITGA4 Integrin alpha-4 1.161e-09 0.45
XIAP_HUMAN XIAP E3 ubiquitin-protein ligase XIAP 1.394e-09 0.33
ACACA_RAT Acaca Acetyl-CoA carboxylase 1 1.663e-09 0.37
LKHA4_CAVPO LTA4H Leukotriene A-4 hydrolase 1.811e-09 0.30
EAA3_HUMAN SLC1A1 Excitatory amino acid transporter 3 2.388e-09 0.35
HPPD_ARATH HPD 4-hydroxyphenylpyruvate dioxygenase 2.491e-09 0.29
CSN5_HUMAN COPS5 COP9 signalosome complex subunit 5 2.603e-09 0.31
MSHR_HUMAN MC1R Melanocyte-stimulating hormone receptor 2.669e-09 0.31
A5A4K8_RABIT MLNR Motilin receptor 2.913e-09 0.31
SAE2_HUMAN UBA2 SUMO-activating enzyme subunit 2 3.246e-09 0.36
Q9YQ12_9HIV1 protease Protease 3.369e-09 0.35
TSPO_RAT Tspo Translocator protein 3.646e-09 0.37
LCK_HUMAN LCK Tyrosine-protein kinase Lck 3.824e-09 0.50
MMP12_HUMAN MMP12 Macrophage metalloelastase 3.844e-09 0.38
PGTB1_BOVIN PGGT1B Geranylgeranyl transferase type-1 subunit beta 3.944e-09 0.43
LIPE_HUMAN LIPG Endothelial lipase 3.972e-09 0.35
ABC3A_HUMAN APOBEC3A DNA dC->dU-editing enzyme APOBEC-3A 3.995e-09 0.39
SAE1_HUMAN SAE1 SUMO-activating enzyme subunit 1 4.13e-09 0.36
NRAM_I34A1 Neuraminidase 4.237e-09 0.34
MMP14_HUMAN MMP14 Matrix metalloproteinase-14 4.813e-09 0.34
ERR3_MOUSE Esrrg Estrogen-related receptor gamma 4.995e-09 0.32
KCNJ2_MOUSE Kcnj2 Inward rectifier potassium channel 2 5.367e-09 0.30
STAT3_HUMAN STAT3 Signal transducer and activator of transcription 3 5.916e-09 0.35
FDFT_RAT Fdft1 Squalene synthase 6.39e-09 0.32
ANPRC_HUMAN NPR3 Atrial natriuretic peptide receptor 3 8.173e-09 0.29
CTRL_HUMAN CTRL Chymotrypsin-like protease CTRL-1 8.173e-09 0.29
NMDE2_HUMAN GRIN2B Glutamate receptor ionotropic, NMDA 2B 9.654e-09 0.37
ITA2_HUMAN ITGA2 Integrin alpha-2 1.183e-08 0.31
MAZF_ECOLI mazF Endoribonuclease toxin MazF 1.257e-08 0.33
ANF_HUMAN NPPA Natriuretic peptides A 1.264e-08 0.31
STE24_YEAST STE24 CAAX prenyl protease 1 1.333e-08 0.37
TAAR1_HUMAN TAAR1 Trace amine-associated receptor 1 1.379e-08 0.39
HYEP_MOUSE Ephx1 Epoxide hydrolase 1 1.515e-08 0.40
VHL_HUMAN VHL von Hippel-Lindau disease tumor suppressor 1.688e-08 0.32
TF_HUMAN F3 Tissue factor 1.734e-08 0.34
NPFF2_RAT Npffr2 Neuropeptide FF receptor 2 1.751e-08 0.28
STF1_HUMAN NR5A1 Steroidogenic factor 1 1.771e-08 0.35
IL2RA_MOUSE Il2ra Interleukin-2 receptor subunit alpha 1.867e-08 0.30
MDM4_HUMAN MDM4 Protein Mdm4 1.93e-08 0.33
ITB1_HUMAN ITGB1 Integrin beta-1 2.046e-08 0.45
SPRE_HUMAN SPR Sepiapterin reductase 2.148e-08 0.31
HDA11_HUMAN HDAC11 Histone deacetylase 11 2.226e-08 0.32
O90781_9PLVG HIV-1 protease HIV-1 protease 2.798e-08 0.32
CTRC_HUMAN CTRC Chymotrypsin-C 2.804e-08 0.32
SC6A3_RAT Slc6a3 Sodium-dependent dopamine transporter 2.96e-08 0.32
PSA_HUMAN NPEPPS Puromycin-sensitive aminopeptidase 3.202e-08 0.34
MYLK_CHICK Mylk Myosin light chain kinase, smooth muscle 3.252e-08 0.29
HEPS_HUMAN HPN Serine protease hepsin 4.715e-08 0.30
GBRA1_RAT Gabra1 Gamma-aminobutyric acid receptor subunit alpha-1 4.807e-08 0.34
OPRM_HUMAN OPRM1 Mu-type opioid receptor 4.822e-08 0.42
CP2D6_HUMAN CYP2D6 Cytochrome P450 2D6 5.41e-08 0.46
S6A13_MOUSE Slc6a13 Sodium- and chloride-dependent GABA transporter 2 5.519e-08 0.30
FAAH1_RAT Faah Fatty-acid amide hydrolase 1 6.043e-08 0.40
PIN1_HUMAN PIN1 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 6.579e-08 0.33
GBRB2_RAT Gabrb2 Gamma-aminobutyric acid receptor subunit beta-2 6.694e-08 0.34
FUCO_HUMAN FUCA1 Tissue alpha-L-fucosidase 7.172e-08 0.37
NR1H4_HUMAN NR1H4 Bile acid receptor 7.725e-08 0.36
CATD_BOVIN CTSD Cathepsin D 7.881e-08 0.46
EGLN1_HUMAN EGLN1 Egl nine homolog 1 7.897e-08 0.32
CPNS1_HUMAN CAPNS1 Calpain small subunit 1 8.165e-08 0.37
SRC_HUMAN SRC Proto-oncogene tyrosine-protein kinase Src 8.256e-08 0.55
P96878_MYCTU Probable transmembrane carbonic anhydrase (Carbonate dehydratase) (Carbonic dehydratase) 8.589e-08 0.37
Q6TUJ4_PSEAI blaIMP-1 Metallo beta-lactamase 8.839e-08 0.29
Q6FTL6_CANGA NCE103 Carbonic anhydrase 8.881e-08 0.36
PANK3_HUMAN PANK3 Pantothenate kinase 3 9.412e-08 0.30
MTP_BOVIN MTTP Microsomal triglyceride transfer protein large subunit 9.833e-08 0.32
Q7ZJM1_9HIV1 pol Integrase 1.083e-07 0.34
GBRA2_RAT Gabra2 Gamma-aminobutyric acid receptor subunit alpha-2 1.134e-07 0.32
A5Z252_9INFA Neuraminidase 1.364e-07 0.32
FUCO_RAT Fuca1 Tissue alpha-L-fucosidase 1.5e-07 0.37
MK08_HUMAN MAPK8 Mitogen-activated protein kinase 8 1.827e-07 0.37
CTRB_BOVIN Chymotrypsinogen B 1.849e-07 0.29
HDAC3_HUMAN HDAC3 Histone deacetylase 3 1.865e-07 0.35
CA2D1_MOUSE Cacna2d1 Voltage-dependent calcium channel subunit alpha-2/delta-1 1.878e-07 0.37
ACPS_BACSU acpS Holo-[acyl-carrier-protein] synthase 1.986e-07 0.30
CTBP2_HUMAN CTBP2 C-terminal-binding protein 2 2.041e-07 0.29
CELA1_HUMAN CELA1 Chymotrypsin-like elastase family member 1 2.448e-07 0.33
GBRG2_RAT Gabrg2 Gamma-aminobutyric acid receptor subunit gamma-2 2.501e-07 0.34
AOFB_RAT Maob Amine oxidase [flavin-containing] B 2.525e-07 0.34
TRPV1_RAT Trpv1 Transient receptor potential cation channel subfamily V member 1 2.597e-07 0.46
CRTM_STAAU crtM 4,4'-diapophytoene synthase 2.784e-07 0.31
MDM2_HUMAN MDM2 E3 ubiquitin-protein ligase Mdm2 3.043e-07 0.35
CAN_CANAL NCE103 Carbonic anhydrase 3.158e-07 0.37
Q8MTZ4_9TRYP PPase1 Vacuolar-type proton translocating pyrophosphatase 1 3.244e-07 0.31
EGFR_MOUSE Egfr Epidermal growth factor receptor 3.374e-07 0.29
FNTB_BOVIN FNTB Protein farnesyltransferase subunit beta 3.549e-07 0.31
LPXC_ECOLI lpxC UDP-3-O-acyl-N-acetylglucosamine deacetylase 3.55e-07 0.36
CXCR4_RAT Cxcr4 C-X-C chemokine receptor type 4 4.547e-07 0.32
LIPC_HUMAN LIPC Hepatic triacylglycerol lipase 5.054e-07 0.35
Q8ST54_TRYCR HK Phosphotransferase 6.072e-07 0.31
ERAP1_HUMAN ERAP1 Endoplasmic reticulum aminopeptidase 1 6.404e-07 0.29
CYSK_MYCTU cysK1 O-acetylserine sulfhydrylase 6.432e-07 0.31
PANC_MYCTU panC Pantothenate synthetase 6.587e-07 0.34
SCNAA_HUMAN SCN10A Sodium channel protein type 10 subunit alpha 7.12e-07 0.32
HDA10_HUMAN HDAC10 Polyamine deacetylase HDAC10 7.161e-07 0.32
CBPB1_HUMAN CPB1 Carboxypeptidase B 7.523e-07 0.32
CAH4_BOVIN CA4 Carbonic anhydrase 4 8.823e-07 0.35
RORA_HUMAN RORA Nuclear receptor ROR-alpha 9.716e-07 0.35
BIRC3_HUMAN BIRC3 Baculoviral IAP repeat-containing protein 3 9.903e-07 0.38
NRAM_I77AB Neuraminidase 1.092e-06 0.32
TGM2_HUMAN TGM2 Protein-glutamine gamma-glutamyltransferase 2 1.18e-06 0.31
POLG_HCV1 Genome polyprotein 1.249e-06 0.37
GASR_HUMAN CCKBR Gastrin/cholecystokinin type B receptor 1.259e-06 0.34
GHSR_HUMAN GHSR Growth hormone secretagogue receptor type 1 1.283e-06 0.32
TS1R3_HUMAN TAS1R3 Taste receptor type 1 member 3 1.29e-06 0.30
TRPM8_RAT Trpm8 Transient receptor potential cation channel subfamily M member 8 1.488e-06 0.31
OPRX_CAVPO OPRL1 Nociceptin receptor 1.611e-06 0.30
OPRK_MOUSE Oprk1 Kappa-type opioid receptor 1.771e-06 0.32
KCNA5_HUMAN KCNA5 Potassium voltage-gated channel subfamily A member 5 1.792e-06 0.38
A3EZI9_9HEPC NS3 Genome polyprotein 1.802e-06 0.34
APEX1_HUMAN APEX1 DNA-(apurinic or apyrimidinic site) lyase 2.453e-06 0.29
CP1A2_HUMAN CYP1A2 Cytochrome P450 1A2 2.963e-06 0.46
RAD51_HUMAN RAD51 DNA repair protein RAD51 homolog 1 3.01e-06 0.31
CNR2_HUMAN CNR2 Cannabinoid receptor 2 3.036e-06 0.38
KDM4A_HUMAN KDM4A Lysine-specific demethylase 4A 3.14e-06 0.34
Q38C41_TRYB2 Phosphotransferase 3.2e-06 0.39
GRIK1_RAT Grik1 Glutamate receptor ionotropic, kainate 1 3.27e-06 0.35
HDAC1_MOUSE Hdac1 Histone deacetylase 1 3.485e-06 0.30
BLA2_BACCE blm Metallo-beta-lactamase type 2 3.572e-06 0.30
STABP_HUMAN STAMBP STAM-binding protein 3.78e-06 0.31
LOXL2_HUMAN LOXL2 Lysyl oxidase homolog 2 3.994e-06 0.29
AA1R_BOVIN ADORA1 Adenosine receptor A1 4.127e-06 0.31
NU1M_BOVIN MT-ND1 NADH-ubiquinone oxidoreductase chain 1 4.129e-06 0.33
NK2R_RAT Tacr2 Substance-K receptor 4.632e-06 0.30
Q3I4V7_CRYNV CAN2 Carbonic anhydrase 4.873e-06 0.37
PRIO_HUMAN PRNP Major prion protein 4.991e-06 0.32
AOFA_RAT Maoa Amine oxidase [flavin-containing] A 5.257e-06 0.35
LYOX_HUMAN LOX Protein-lysine 6-oxidase 5.875e-06 0.29
SYTC_HUMAN TARS1 Threonine--tRNA ligase 1, cytoplasmic 6.502e-06 0.29
SYT_YERPE thrS Threonine--tRNA ligase 6.502e-06 0.29
PPARD_HUMAN PPARD Peroxisome proliferator-activated receptor delta 6.964e-06 0.32
GRAB_HUMAN GZMB Granzyme B 7.581e-06 0.29
CATE_HUMAN CTSE Cathepsin E 7.665e-06 0.33
ABC3G_HUMAN APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G 8.473e-06 0.39
STAT6_HUMAN STAT6 Signal transducer and activator of transcription 6 8.741e-06 0.29
NOD2_HUMAN NOD2 Nucleotide-binding oligomerization domain-containing protein 2 8.884e-06 0.30
CBPB2_HUMAN CPB2 Carboxypeptidase B2 9.032e-06 0.34
FFAR1_HUMAN FFAR1 Free fatty acid receptor 1 9.165e-06 0.31
KLK7_HUMAN KLK7 Kallikrein-7 9.291e-06 0.30

Lumateperone

5HT2C_HUMAN HTR2C 5-hydroxytryptamine receptor 2C 5.934e-40 1.00
DRD2_RAT Drd2 D(2) dopamine receptor 2.598e-39 1.00
5HT2A_HUMAN HTR2A 5-hydroxytryptamine receptor 2A 1.504e-38 1.00
DRD4_HUMAN DRD4 D(4) dopamine receptor 8.33e-25 1.00
5HT1A_HUMAN HTR1A 5-hydroxytryptamine receptor 1A 1.11e-16 1.00
ADA1B_HUMAN ADRA1B Alpha-1B adrenergic receptor 1.247e-11 1.00
ADA1A_HUMAN ADRA1A Alpha-1A adrenergic receptor 2.353e-11 1.00
DRD1_HUMAN DRD1 D(1A) dopamine receptor 2.274e-08 1.00
SC6A4_HUMAN SLC6A4 Sodium-dependent serotonin transporter 4.686e-06 1.00
DRD5_RAT Drd5 D(1B) dopamine receptor 6.403e-89 0.55
CP2J2_HUMAN CYP2J2 Cytochrome P450 2J2 1.886e-85 0.39
RET4_HUMAN RBP4 Retinol-binding protein 4 6.282e-50 0.34
VACHT_HUMAN SLC18A3 Vesicular acetylcholine transporter 3.197e-44 0.46
DRD1_PIG DRD1 D(1A) dopamine receptor 1.325e-43 0.43
DRD2_MOUSE Drd2 D(2) dopamine receptor 2.024e-40 0.47
DRD4_RAT Drd4 D(4) dopamine receptor 4.189e-40 0.55
5HT2A_MACMU HTR2A 5-hydroxytryptamine receptor 2A 1.007e-38 0.31
SGMR1_MOUSE Sigmar1 Sigma non-opioid intracellular receptor 1 6.395e-35 0.47
ZN664_CAVPO ZNF664 Zinc finger protein 664 3.702e-33 0.41
5HT7R_MOUSE Htr7 5-hydroxytryptamine receptor 7 1.876e-32 0.40
5HT2C_RAT Htr2c 5-hydroxytryptamine receptor 2C 7.318e-32 0.50
5HT3B_MOUSE Htr3b 5-hydroxytryptamine receptor 3B 1.596e-31 0.48
5HT7R_RAT Htr7 5-hydroxytryptamine receptor 7 7.544e-31 0.41
5HT2A_RAT Htr2a 5-hydroxytryptamine receptor 2A 2.009e-30 0.53
5HT2B_RAT Htr2b 5-hydroxytryptamine receptor 2B 2.105e-30 0.45
Q4DCQ3_TRYCC Superoxide dismutase 9.393e-28 0.34
MCHR1_RAT Mchr1 Melanin-concentrating hormone receptor 1 4.089e-27 0.39
DRD2_HUMAN DRD2 D(2) dopamine receptor 9.861e-27 0.71
5HT2A_PIG HTR2A 5-hydroxytryptamine receptor 2A 4.739e-26 0.43
5HT1F_HUMAN HTR1F 5-hydroxytryptamine receptor 1F 4.014e-25 0.32
CCR3_HUMAN CCR3 C-C chemokine receptor type 3 5.342e-25 0.78
5HT7R_CAVPO HTR7 5-hydroxytryptamine receptor 7 1.368e-24 0.30
HRH1_HUMAN HRH1 Histamine H1 receptor 1.509e-23 0.47
H10_HUMAN H1-0 Histone H1.0 2.314e-21 0.41
SC6A1_HUMAN SLC6A1 Sodium- and chloride-dependent GABA transporter 1 1.105e-20 0.31
DRD1_RAT Drd1 D(1A) dopamine receptor 1.997e-19 0.53
5HT1A_RAT Htr1a 5-hydroxytryptamine receptor 1A 2.591e-19 0.50
SGMR2_RAT Tmem97 Sigma intracellular receptor 2 1.075e-18 0.41
SC6A1_RAT Slc6a1 Sodium- and chloride-dependent GABA transporter 1 1.395e-18 0.33
CASB_RAT Csn2 Beta-casein 3.542e-18 0.40
HRH2_HUMAN HRH2 Histamine H2 receptor 5.527e-18 0.41
5HT5A_MOUSE Htr5a 5-hydroxytryptamine receptor 5A 1.163e-17 0.41
5HT7R_HUMAN HTR7 5-hydroxytryptamine receptor 7 2.22e-16 0.47
5HT2A_CANLF HTR2A 5-hydroxytryptamine receptor 2A 4.441e-16 0.31
HRH3_RAT Hrh3 Histamine H3 receptor 4.441e-16 0.32
DRD3_HUMAN DRD3 D(3) dopamine receptor 9.992e-16 0.55
CCR3_RAT Ccr3 C-C chemokine receptor type 3 3.553e-15 0.31
SC6A1_MOUSE Slc6a1 Sodium- and chloride-dependent GABA transporter 1 9.359e-14 0.31
SGMR1_CAVPO SIGMAR1 Sigma non-opioid intracellular receptor 1 1.437e-13 0.46
DRD3_RAT Drd3 D(3) dopamine receptor 2.639e-13 0.55
SC6A3_MACFA SLC6A3 Sodium-dependent dopamine transporter 3.656e-13 0.28
NLRP1_HUMAN NLRP1 NACHT, LRR and PYD domains-containing protein 1 4.751e-13 0.28
KCNK2_HUMAN KCNK2 Potassium channel subfamily K member 2 7.195e-13 0.41
DHI1_HUMAN HSD11B1 Corticosteroid 11-beta-dehydrogenase isozyme 1 3.365e-12 0.33
VMAT2_MOUSE Slc18a2 Synaptic vesicular amine transporter 4.33e-12 0.29
MURB_STAAU murB UDP-N-acetylenolpyruvoylglucosamine reductase 4.628e-12 0.29
AP2S1_RAT Ap2s1 AP-2 complex subunit sigma 4.659e-12 0.41
DRD3_CHLAE DRD3 D(3) dopamine receptor 2.27e-11 0.41
MURA_ECOLI murA UDP-N-acetylglucosamine 1-carboxyvinyltransferase 5.659e-11 0.29
ERG2_YEAST ERG2 C-8 sterol isomerase 1.118e-10 0.42
CCR3_MOUSE Ccr3 Probable C-C chemokine receptor type 3 2.944e-10 0.30
SGMR1_RAT Sigmar1 Sigma non-opioid intracellular receptor 1 6.395e-10 0.48
Q5TKS5_STAAU fabI Enoyl-ACP reductase 1.014e-09 0.31
DRD5_HUMAN DRD5 D(1B) dopamine receptor 2.08e-09 0.41
MURB_ECOLI murB UDP-N-acetylenolpyruvoylglucosamine reductase 2.906e-09 0.35
EBP_HUMAN EBP 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase 3.91e-09 0.42
VACHT_RAT Slc18a3 Vesicular acetylcholine transporter 6.568e-09 0.41
5HT1B_RAT Htr1b 5-hydroxytryptamine receptor 1B 8.701e-09 0.40
SQHC_ALIAD shc Squalene--hopene cyclase 1.102e-08 0.32
MCHR1_HUMAN MCHR1 Melanin-concentrating hormone receptor 1 1.233e-08 0.41
SGMR1_HUMAN SIGMAR1 Sigma non-opioid intracellular receptor 1 1.323e-08 0.46
ADA1D_HUMAN ADRA1D Alpha-1D adrenergic receptor 1.944e-08 0.41
PDE6D_HUMAN PDE6D Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta 3.413e-08 0.29
VMAT2_HUMAN SLC18A2 Synaptic vesicular amine transporter 6.174e-08 0.29
HRH1_RAT Hrh1 Histamine H1 receptor 6.335e-08 0.48
PLD2_HUMAN PLD2 Phospholipase D2 7.184e-08 0.30
5HT1D_HUMAN HTR1D 5-hydroxytryptamine receptor 1D 1.068e-07 0.32
ACES_RAT Ache Acetylcholinesterase 1.346e-07 0.31
SL9A1_HUMAN SLC9A1 Sodium/hydrogen exchanger 1 2.092e-07 0.32
ADA2B_HUMAN ADRA2B Alpha-2B adrenergic receptor 2.811e-07 0.41
DRD2_CHLAE DRD2 D(2) dopamine receptor 2.948e-07 0.41
ADA1B_MESAU ADRA1B Alpha-1B adrenergic receptor 3.265e-07 0.30
ADA2C_HUMAN ADRA2C Alpha-2C adrenergic receptor 5.087e-07 0.45
EIS_MYCTU eis N-acetyltransferase Eis 8.142e-07 0.30
5HT1B_HUMAN HTR1B 5-hydroxytryptamine receptor 1B 1.004e-06 0.32
ADA1A_RAT Adra1a Alpha-1A adrenergic receptor 1.295e-06 0.41
ADA1B_RAT Adra1b Alpha-1B adrenergic receptor 2.319e-06 0.41
VACHT_TETCF Vesicular acetylcholine transporter 2.387e-06 0.30
DCNL1_HUMAN DCUN1D1 DCN1-like protein 1 3.018e-06 0.30
PLD1_RAT Pld1 Phospholipase D1 3.36e-06 0.30
HRH1_CAVPO HRH1 Histamine H1 receptor 7.561e-06 0.41
CA2D1_RAT Cacna2d1 Voltage-dependent calcium channel subunit alpha-2/delta-1 9.885e-06 0.29

Lonafarnib

FNTB_HUMAN FNTB Protein farnesyltransferase subunit beta 4.094e-36 1.00
FNTA_HUMAN FNTA Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha 6.596e-34 1.00
RASH_HUMAN HRAS GTPase HRas 3.137e-13 1.00
FNTA_MOUSE Fnta Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha 2.676e-08 1.00
FNTB_MOUSE Fntb Protein farnesyltransferase subunit beta 2.676e-08 1.00
FNTB_RAT Fntb Protein farnesyltransferase subunit beta 1.722e-07 1.00
FNTA_RAT Fnta Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha 1.96e-07 1.00
FNTB_BOVIN FNTB Protein farnesyltransferase subunit beta 0.0003428 1.00
FNTA_BOVIN FNTA Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha 0.001587 1.00
MDR1_HUMAN ABCB1 ATP-dependent translocase ABCB1 0.2687 1.00
S6A15_HUMAN SLC6A15 Sodium-dependent neutral amino acid transporter B(0)AT2 2.22e-16 0.36
FABI_STAA8 fabI Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI 1.733e-12 0.29
ENPP2_HUMAN ENPP2 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 1.08e-10 0.33
FABI_STAAR fabI Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI 1.046e-07 0.29
HRH1_RAT Hrh1 Histamine H1 receptor 4.319e-06 0.34

Silodosin

ADA1D_HUMAN ADRA1D Alpha-1D adrenergic receptor 9.959e-31 1.00
ADA1B_HUMAN ADRA1B Alpha-1B adrenergic receptor 1.212e-28 1.00
ADA1A_HUMAN ADRA1A Alpha-1A adrenergic receptor 5.485e-26 1.00
ADA1A_RAT Adra1a Alpha-1A adrenergic receptor 0.0009714 1.00
KCNH2_HUMAN KCNH2 Potassium voltage-gated channel subfamily H member 2 0.9985 1.00
ADA1A_RABIT ADRA1A Alpha-1A adrenergic receptor 6.511e-19 0.36
RENI_CALJA REN Renin 8.36e-11 0.30
PE2R4_HUMAN PTGER4 Prostaglandin E2 receptor EP4 subtype 4.081e-10 0.33
NEK9_HUMAN NEK9 Serine/threonine-protein kinase Nek9 5.468e-08 0.28
ADA1D_RAT Adra1d Alpha-1D adrenergic receptor 6.583e-08 0.46
NEK5_HUMAN NEK5 Serine/threonine-protein kinase Nek5 6.427e-07 0.28
PI51C_HUMAN PIP5K1C Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma 6.427e-07 0.28
M3K1_HUMAN MAP3K1 Mitogen-activated protein kinase kinase kinase 1 1.217e-06 0.28
NIM1_HUMAN NIM1K Serine/threonine-protein kinase NIM1 1.217e-06 0.28
BRSK2_HUMAN BRSK2 Serine/threonine-protein kinase BRSK2 5.781e-06 0.28

Ingenol_mebutate

KPCD_HUMAN PRKCD Protein kinase C delta type 1.547e-28 1.00
KPCD_MOUSE Prkcd Protein kinase C delta type 5.605e-09 0.74
MYB_CHICK MYB Transcriptional activator Myb 1.845e-06 0.30

Levocetirizine

HRH1_HUMAN HRH1 Histamine H1 receptor 5.095e-28 1.00
CAC1B_RAT Cacna1b Voltage-dependent N-type calcium channel subunit alpha-1B 4.958e-110 0.55
CACB1_RAT Cacnb1 Voltage-dependent L-type calcium channel subunit beta-1 3.196e-98 0.55
CA2D2_RAT Cacna2d2 Voltage-dependent calcium channel subunit alpha-2/delta-2 2.435e-90 0.55
CACB1_HUMAN CACNB1 Voltage-dependent L-type calcium channel subunit beta-1 2.435e-90 0.55
CAC1A_HUMAN CACNA1A Voltage-dependent P/Q-type calcium channel subunit alpha-1A 9.472e-82 0.55
CA2D1_RAT Cacna2d1 Voltage-dependent calcium channel subunit alpha-2/delta-1 8.033e-70 0.53
DRD4_RAT Drd4 D(4) dopamine receptor 1.273e-69 0.40
SC6A3_RAT Slc6a3 Sodium-dependent dopamine transporter 2.581e-61 0.43
SC6A4_RAT Slc6a4 Sodium-dependent serotonin transporter 1.706e-52 0.45
CAC1G_HUMAN CACNA1G Voltage-dependent T-type calcium channel subunit alpha-1G 1.936e-51 0.55
SC6A1_RAT Slc6a1 Sodium- and chloride-dependent GABA transporter 1 5.371e-49 0.41
NMUR1_HUMAN NMUR1 Neuromedin-U receptor 1 1.653e-47 0.39
PA24A_HUMAN PLA2G4A Cytosolic phospholipase A2 5.484e-46 0.34
NMUR2_HUMAN NMUR2 Neuromedin-U receptor 2 4.867e-44 0.39
5HT7R_HUMAN HTR7 5-hydroxytryptamine receptor 7 4.162e-42 0.44
DRD4_HUMAN DRD4 D(4) dopamine receptor 5.12e-41 0.44
DRD2_HUMAN DRD2 D(2) dopamine receptor 4.541e-40 0.74
CCR1_HUMAN CCR1 C-C chemokine receptor type 1 8.295e-37 0.40
5HT1A_RAT Htr1a 5-hydroxytryptamine receptor 1A 1.415e-36 0.55
SCN2A_RAT Scn2a Sodium channel protein type 2 subunit alpha 1.144e-35 0.37
O19067_PIG N-methyl-D-aspartate receptor 1.377e-35 0.28
TYRP1_MOUSE Tyrp1 5,6-dihydroxyindole-2-carboxylic acid oxidase 4.217e-35 0.29
5HT1A_HUMAN HTR1A 5-hydroxytryptamine receptor 1A 2.006e-34 0.45
DRD3_HUMAN DRD3 D(3) dopamine receptor 2.471e-34 0.62
5HT2A_RAT Htr2a 5-hydroxytryptamine receptor 2A 4.274e-33 0.55
OPRX_HUMAN OPRL1 Nociceptin receptor 6.238e-32 0.46
NK2R_BOVIN TACR2 Substance-K receptor 5.36e-31 0.31
HRH3_CAVPO HRH3 Histamine H3 receptor 1.042e-30 0.36
PI2R_HUMAN PTGIR Prostacyclin receptor 1.677e-30 0.41
US28_HCMVA US28 G-protein coupled receptor homolog US28 5.397e-27 0.40
SGMR1_HUMAN SIGMAR1 Sigma non-opioid intracellular receptor 1 8.757e-26 0.41
CCR5_HUMAN CCR5 C-C chemokine receptor type 5 3.404e-25 0.40
TYTR_TRYBB TPR Trypanothione reductase 1.157e-24 0.34
Q6A2E2_AEDAE ace-1 Acetylcholinesterase 8.657e-24 0.29
ZN664_CAVPO ZNF664 Zinc finger protein 664 1.926e-23 0.29
SC6A3_HUMAN SLC6A3 Sodium-dependent dopamine transporter 2.058e-23 0.43
SC6A4_HUMAN SLC6A4 Sodium-dependent serotonin transporter 3.945e-23 0.43
DRD5_HUMAN DRD5 D(1B) dopamine receptor 4.042e-23 0.35
PCP_HUMAN PRCP Lysosomal Pro-X carboxypeptidase 4.877e-23 0.40
Q63380_RAT NET Transporter 2.078e-22 0.36
SGMR1_CAVPO SIGMAR1 Sigma non-opioid intracellular receptor 1 2.463e-22 0.41
OPRD_HUMAN OPRD1 Delta-type opioid receptor 5.456e-22 0.50
HRH1_CAVPO HRH1 Histamine H1 receptor 1.005e-21 0.42
5HT2A_HUMAN HTR2A 5-hydroxytryptamine receptor 2A 2.925e-21 0.74
Q56D28_CAVPO CRTH2 Chemoattractant receptor-homologous molecule expressed on Th2 cells 3.935e-21 0.36
HRH2_HUMAN HRH2 Histamine H2 receptor 4.225e-20 0.35
MGLL_MOUSE Mgll Monoglyceride lipase 5.447e-20 0.43
PCP_MOUSE Prcp Lysosomal Pro-X carboxypeptidase 1.97e-19 0.40
SC6A1_MOUSE Slc6a1 Sodium- and chloride-dependent GABA transporter 1 2.63e-19 0.38
ADA1B_RAT Adra1b Alpha-1B adrenergic receptor 3.397e-19 0.41
GP139_HUMAN GPR139 Probable G-protein coupled receptor 139 1.883e-18 0.32
CP2D6_HUMAN CYP2D6 Cytochrome P450 2D6 3.586e-18 0.74
DRD1_PIG DRD1 D(1A) dopamine receptor 1.11e-16 0.32
OPRM_HUMAN OPRM1 Mu-type opioid receptor 1.11e-16 0.48
PD2R2_HUMAN PTGDR2 Prostaglandin D2 receptor 2 1.11e-16 0.36
PI2R_RAT Ptgir Prostacyclin receptor 3.331e-16 0.35
PA_I000X PA Polymerase acidic protein 6.661e-16 0.30
Q9WTR4_RAT Slc6a2 Transporter 3.331e-15 0.38
H10_HUMAN H1-0 Histone H1.0 3.442e-15 0.29
HRH3_HUMAN HRH3 Histamine H3 receptor 4.663e-15 0.36
MGLL_RAT Mgll Monoglyceride lipase 5.107e-15 0.36
LKHA4_HUMAN LTA4H Leukotriene A-4 hydrolase 5.884e-15 0.38
Q8HY88_BOVIN KCNK2 Potassium channel subfamily K member 2 1.166e-14 0.36
DRD1_HUMAN DRD1 D(1A) dopamine receptor 2.331e-14 0.37
OPRK_HUMAN OPRK1 Kappa-type opioid receptor 2.398e-14 0.46
DRD2_RAT Drd2 D(2) dopamine receptor 4.607e-14 0.38
SC6A2_HUMAN SLC6A2 Sodium-dependent noradrenaline transporter 5.596e-14 0.40
NK2R_RAT Tacr2 Substance-K receptor 1.458e-13 0.31
SL9A3_RAT Slc9a3 Sodium/hydrogen exchanger 3 1.472e-13 0.30
ACES_ELEEL ache Acetylcholinesterase 2.034e-13 0.43
5HT2C_RAT Htr2c 5-hydroxytryptamine receptor 2C 3.11e-13 0.55
NK2R_HUMAN TACR2 Substance-K receptor 8.368e-13 0.32
SHIP2_HUMAN INPPL1 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 8.444e-13 0.31
MAP11_HUMAN METAP1 Methionine aminopeptidase 1 1.112e-12 0.30
DRD3_RAT Drd3 D(3) dopamine receptor 1.705e-12 0.33
FABPH_HUMAN FABP3 Fatty acid-binding protein, heart 1.832e-12 0.30
PDR5_YEAST PDR5 Pleiotropic ABC efflux transporter of multiple drugs 2.162e-12 0.30
FAAH1_HUMAN FAAH Fatty-acid amide hydrolase 1 2.779e-12 0.36
ADA1D_HUMAN ADRA1D Alpha-1D adrenergic receptor 5.336e-12 0.41
CA2D1_HUMAN CACNA2D1 Voltage-dependent calcium channel subunit alpha-2/delta-1 5.806e-12 0.55
S6A12_MOUSE Slc6a12 Sodium- and chloride-dependent betaine transporter 6.161e-12 0.32
CNR1_RAT Cnr1 Cannabinoid receptor 1 6.543e-12 0.43
CD69_HUMAN CD69 Early activation antigen CD69 7.616e-12 0.29
CNR1_HUMAN CNR1 Cannabinoid receptor 1 7.791e-12 0.43
TRPM2_HUMAN TRPM2 Transient receptor potential cation channel subfamily M member 2 8.017e-12 0.29
ADA1A_HUMAN ADRA1A Alpha-1A adrenergic receptor 8.629e-12 0.39
MC4R_HUMAN MC4R Melanocortin receptor 4 1.287e-11 0.40
SC6A4_MOUSE Slc6a4 Sodium-dependent serotonin transporter 1.388e-11 0.36
CALM_BOVIN CALM Calmodulin 1.754e-11 0.31
EBP_CAVPO EBP 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase 3.343e-11 0.32
DHCR7_HUMAN DHCR7 7-dehydrocholesterol reductase 7.435e-11 0.32
MGLL_HUMAN MGLL Monoglyceride lipase 9.299e-11 0.36
UR2R_HUMAN UTS2R Urotensin-2 receptor 1.43e-10 0.42
5HT2C_HUMAN HTR2C 5-hydroxytryptamine receptor 2C 1.554e-10 0.41
SGMR2_RAT Tmem97 Sigma intracellular receptor 2 2.011e-10 0.32
O31048_PORGN DPP IV Dipeptidyl peptidase IV 2.055e-10 0.48
KCNA5_HUMAN KCNA5 Potassium voltage-gated channel subfamily A member 5 2.57e-10 0.45
SGMR1_RAT Sigmar1 Sigma non-opioid intracellular receptor 1 3.561e-10 0.36
INHA_MYCTU inhA Enoyl-[acyl-carrier-protein] reductase [NADH] 4.2e-10 0.43
SGMR2_HUMAN TMEM97 Sigma intracellular receptor 2 4.942e-10 0.34
LOX5_HUMAN ALOX5 Arachidonate 5-lipoxygenase 5.725e-10 0.52
NOS2_MOUSE Nos2 Nitric oxide synthase, inducible 8.26e-10 0.32
ADA1B_HUMAN ADRA1B Alpha-1B adrenergic receptor 9.369e-10 0.48
SC6A1_HUMAN SLC6A1 Sodium- and chloride-dependent GABA transporter 1 9.404e-10 0.32
ADA1A_RAT Adra1a Alpha-1A adrenergic receptor 1.185e-09 0.40
GABR2_RAT Gabbr2 Gamma-aminobutyric acid type B receptor subunit 2 1.547e-09 0.33
MCHR1_RAT Mchr1 Melanin-concentrating hormone receptor 1 2.231e-09 0.32
KCNK2_HUMAN KCNK2 Potassium channel subfamily K member 2 3.108e-09 0.29
O31272_9GAMM imiS Beta-lactamase 3.598e-09 0.29
5HT7R_RAT Htr7 5-hydroxytryptamine receptor 7 3.749e-09 0.30
5HT4R_RAT Htr4 5-hydroxytryptamine receptor 4 5.767e-09 0.38
MRP2_HUMAN ABCC2 Canalicular multispecific organic anion transporter 1 7.167e-09 0.33
AP2S1_RAT Ap2s1 AP-2 complex subunit sigma 1.153e-08 0.29
Q6L5J4_HUMAN FPRL2 FML2_HUMAN 1.253e-08 0.32
S6A13_MOUSE Slc6a13 Sodium- and chloride-dependent GABA transporter 2 1.613e-08 0.32
5HT2B_HUMAN HTR2B 5-hydroxytryptamine receptor 2B 1.641e-08 0.41
MEP50_HUMAN WDR77 Methylosome protein 50 1.908e-08 0.34
ANM5_HUMAN PRMT5 Protein arginine N-methyltransferase 5 2.331e-08 0.34
NK1R_HUMAN TACR1 Substance-P receptor 2.487e-08 0.51
MDR1_HUMAN ABCB1 ATP-dependent translocase ABCB1 3.217e-08 0.39
DRD3_CHLAE DRD3 D(3) dopamine receptor 3.505e-08 0.29
WNK1_HUMAN WNK1 Serine/threonine-protein kinase WNK1 3.548e-08 0.29
ADA2A_RAT Adra2a Alpha-2A adrenergic receptor 4.755e-08 0.29
OPRD_RAT Oprd1 Delta-type opioid receptor 7.79e-08 0.50
RCE1_YEAST RCE1 CAAX prenyl protease 2 1.203e-07 0.41
5HT1A_MOUSE Htr1a 5-hydroxytryptamine receptor 1A 1.64e-07 0.30
ACM1_HUMAN CHRM1 Muscarinic acetylcholine receptor M1 1.729e-07 0.41
CASR_HUMAN CASR Extracellular calcium-sensing receptor 2.156e-07 0.33
ADA2B_HUMAN ADRA2B Alpha-2B adrenergic receptor 2.406e-07 0.40
SC6A3_MOUSE Slc6a3 Sodium-dependent dopamine transporter 2.407e-07 0.36
CCR3_HUMAN CCR3 C-C chemokine receptor type 3 2.455e-07 0.37
PA_I34A1 PA Polymerase acidic protein 2.471e-07 0.30
FABP4_HUMAN FABP4 Fatty acid-binding protein, adipocyte 3.151e-07 0.31
GABR1_RAT Gabbr1 Gamma-aminobutyric acid type B receptor subunit 1 4.324e-07 0.33
DRD2_MOUSE Drd2 D(2) dopamine receptor 4.598e-07 0.30
SCN4A_HUMAN SCN4A Sodium channel protein type 4 subunit alpha 6.622e-07 0.30
GABR2_HUMAN GABBR2 Gamma-aminobutyric acid type B receptor subunit 2 7.828e-07 0.33
GP183_HUMAN GPR183 G-protein coupled receptor 183 7.94e-07 0.34
PD2R2_MOUSE Ptgdr2 Prostaglandin D2 receptor 2 1.09e-06 0.30
B2LA1_MOUSE Bcl2a1 Bcl-2-related protein A1 1.203e-06 0.31
GABR1_HUMAN GABBR1 Gamma-aminobutyric acid type B receptor subunit 1 1.288e-06 0.33
CA2D1_MOUSE Cacna2d1 Voltage-dependent calcium channel subunit alpha-2/delta-1 1.656e-06 0.31
ACM5_HUMAN CHRM5 Muscarinic acetylcholine receptor M5 1.659e-06 0.41
FPR2_HUMAN FPR2 N-formyl peptide receptor 2 1.692e-06 0.32
ACM1_RAT Chrm1 Muscarinic acetylcholine receptor M1 1.736e-06 0.33
5HT2A_PIG HTR2A 5-hydroxytryptamine receptor 2A 1.905e-06 0.32
SL9A3_HUMAN SLC9A3 Sodium/hydrogen exchanger 3 2.094e-06 0.30
PPARA_HUMAN PPARA Peroxisome proliferator-activated receptor alpha 2.112e-06 0.33
SENP1_HUMAN SENP1 Sentrin-specific protease 1 2.32e-06 0.29
ADA2A_HUMAN ADRA2A Alpha-2A adrenergic receptor 2.474e-06 0.41
ACHP_LYMST Acetylcholine-binding protein 2.476e-06 0.34
GP183_MOUSE Gpr183 G-protein coupled receptor 183 2.907e-06 0.34
ADA2C_HUMAN ADRA2C Alpha-2C adrenergic receptor 2.948e-06 0.40
DCNL1_HUMAN DCUN1D1 DCN1-like protein 1 3.432e-06 0.30
5HT4R_HUMAN HTR4 5-hydroxytryptamine receptor 4 4.032e-06 0.32
CAC1C_CAVPO CACNA1C Voltage-dependent L-type calcium channel subunit alpha-1C 4.295e-06 0.36
HCN1_HUMAN HCN1 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 7.581e-06 0.29

Saxagliptin

DPP4_HUMAN DPP4 Dipeptidyl peptidase 4 3.872e-25 1.00
DPP9_HUMAN DPP9 Dipeptidyl peptidase 9 4.077e-06 1.00
DPP8_HUMAN DPP8 Dipeptidyl peptidase 8 7.564e-06 1.00
DPP4_PIG DPP4 Dipeptidyl peptidase 4 3.527e-57 0.56
E1BI31_BOVIN DPP9 Dipeptidyl peptidase 9 4.146e-25 0.40
DPP4_RAT Dpp4 Dipeptidyl peptidase 4 3.386e-06 0.40

Pazopanib

CD11A_HUMAN CDK11A Cyclin-dependent kinase 11A 7.773e-24 1.00
NEK5_HUMAN NEK5 Serine/threonine-protein kinase Nek5 9.712e-23 1.00
PI51C_HUMAN PIP5K1C Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma 9.712e-23 1.00
M3K1_HUMAN MAP3K1 Mitogen-activated protein kinase kinase kinase 1 9.163e-22 1.00
CD11B_HUMAN CDK11B Cyclin-dependent kinase 11B 6.843e-21 1.00
AVR2B_HUMAN ACVR2B Activin receptor type-2B 4.197e-20 1.00
KCC1G_HUMAN CAMK1G Calcium/calmodulin-dependent protein kinase type 1G 4.197e-20 1.00
MP2K6_HUMAN MAP2K6 Dual specificity mitogen-activated protein kinase kinase 6 3.874e-18 1.00
TXK_HUMAN TXK Tyrosine-protein kinase TXK 7.987e-18 1.00
PGFRA_HUMAN PDGFRA Platelet-derived growth factor receptor alpha 1.476e-17 1.00
CDPK1_PLAF7 CPK1 Calcium-dependent protein kinase 1 1.11e-16 1.00
RIOK2_HUMAN RIOK2 Serine/threonine-protein kinase RIO2 3.331e-16 1.00
STK36_HUMAN STK36 Serine/threonine-protein kinase 36 3.331e-16 1.00
YES_HUMAN YES1 Tyrosine-protein kinase Yes 1.887e-15 1.00
MYLK2_HUMAN MYLK2 Myosin light chain kinase 2, skeletal/cardiac muscle 2.22e-15 1.00
SRC_HUMAN SRC Proto-oncogene tyrosine-protein kinase Src 3.553e-15 1.00
IRAK3_HUMAN IRAK3 Interleukin-1 receptor-associated kinase 3 5.218e-15 1.00
TNK1_HUMAN TNK1 Non-receptor tyrosine-protein kinase TNK1 1.144e-14 1.00
MP2K4_HUMAN MAP2K4 Dual specificity mitogen-activated protein kinase kinase 4 2.387e-14 1.00
VGFR2_HUMAN KDR Vascular endothelial growth factor receptor 2 4.141e-14 1.00
BMP2K_HUMAN BMP2K BMP-2-inducible protein kinase 9.259e-14 1.00
SIK1_HUMAN SIK1 Serine/threonine-protein kinase SIK1 9.259e-14 1.00
TAOK2_HUMAN TAOK2 Serine/threonine-protein kinase TAO2 9.259e-14 1.00
STK16_HUMAN STK16 Serine/threonine-protein kinase 16 1.731e-13 1.00
M4K3_HUMAN MAP4K3 Mitogen-activated protein kinase kinase kinase kinase 3 3.137e-13 1.00
M3K2_HUMAN MAP3K2 Mitogen-activated protein kinase kinase kinase 2 5.523e-13 1.00
NLK_HUMAN NLK Serine/threonine-protein kinase NLK 5.523e-13 1.00
M4K1_HUMAN MAP4K1 Mitogen-activated protein kinase kinase kinase kinase 1 9.469e-13 1.00
CDK16_HUMAN CDK16 Cyclin-dependent kinase 16 1.584e-12 1.00
BMR1B_HUMAN BMPR1B Bone morphogenetic protein receptor type-1B 4.142e-12 1.00
TIE1_HUMAN TIE1 Tyrosine-protein kinase receptor Tie-1 1.001e-11 1.00
AAK1_HUMAN AAK1 AP2-associated protein kinase 1 3.307e-11 1.00
EPHB6_HUMAN EPHB6 Ephrin type-B receptor 6 3.307e-11 1.00
SIK2_HUMAN SIK2 Serine/threonine-protein kinase SIK2 6.82e-11 1.00
KSYK_HUMAN SYK Tyrosine-protein kinase SYK 8.818e-11 1.00
M3K10_HUMAN MAP3K10 Mitogen-activated protein kinase kinase kinase 10 9.605e-11 1.00
SRMS_HUMAN SRMS Tyrosine-protein kinase Srms 1.017e-10 1.00
MP2K5_HUMAN MAP2K5 Dual specificity mitogen-activated protein kinase kinase 5 1.839e-10 1.00
FGR_HUMAN FGR Tyrosine-protein kinase Fgr 2.058e-10 1.00
CDK7_HUMAN CDK7 Cyclin-dependent kinase 7 2.38e-10 1.00
KIT_HUMAN KIT Mast/stem cell growth factor receptor Kit 2.672e-10 1.00
STK10_HUMAN STK10 Serine/threonine-protein kinase 10 3.375e-10 1.00
ABL2_HUMAN ABL2 Tyrosine-protein kinase ABL2 5.958e-10 1.00
LCK_HUMAN LCK Tyrosine-protein kinase Lck 1.272e-09 1.00
M3K19_HUMAN MAP3K19 Mitogen-activated protein kinase kinase kinase 19 2.698e-09 1.00
M3K11_HUMAN MAP3K11 Mitogen-activated protein kinase kinase kinase 11 3.385e-09 1.00
PI42C_HUMAN PIP4K2C Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma 1.172e-08 1.00
RIPK2_HUMAN RIPK2 Receptor-interacting serine/threonine-protein kinase 2 2.428e-08 1.00
M3K9_HUMAN MAP3K9 Mitogen-activated protein kinase kinase kinase 9 2.882e-08 1.00
E2AK2_HUMAN EIF2AK2 Interferon-induced, double-stranded RNA-activated protein kinase 3.408e-08 1.00
TGFR2_HUMAN TGFBR2 TGF-beta receptor type-2 3.408e-08 1.00
GAK_HUMAN GAK Cyclin-G-associated kinase 3.215e-07 1.00
AURKC_HUMAN AURKC Aurora kinase C 3.618e-07 1.00
LYN_HUMAN LYN Tyrosine-protein kinase Lyn 3.643e-07 1.00
BLK_HUMAN BLK Tyrosine-protein kinase Blk 3.81e-07 1.00
KCC1A_HUMAN CAMK1 Calcium/calmodulin-dependent protein kinase type 1 5.68e-07 1.00
FES_HUMAN FES Tyrosine-protein kinase Fes/Fps 7.034e-07 1.00
FER_HUMAN FER Tyrosine-protein kinase Fer 1.36e-06 1.00
TAOK3_HUMAN TAOK3 Serine/threonine-protein kinase TAO3 2.404e-06 1.00
FRK_HUMAN FRK Tyrosine-protein kinase FRK 2.666e-06 1.00
ROS1_HUMAN ROS1 Proto-oncogene tyrosine-protein kinase ROS 3.674e-06 1.00
FGFR1_HUMAN FGFR1 Fibroblast growth factor receptor 1 8.572e-06 1.00
FYN_HUMAN FYN Tyrosine-protein kinase Fyn 9.905e-06 1.00
DDR2_HUMAN DDR2 Discoidin domain-containing receptor 2 1.363e-05 1.00
PTK6_HUMAN PTK6 Protein-tyrosine kinase 6 1.51e-05 1.00
DDR1_HUMAN DDR1 Epithelial discoidin domain-containing receptor 1 1.54e-05 1.00
IRAK1_HUMAN IRAK1 Interleukin-1 receptor-associated kinase 1 2.007e-05 1.00
PGFRB_HUMAN PDGFRB Platelet-derived growth factor receptor beta 2.985e-05 1.00
SLK_HUMAN SLK STE20-like serine/threonine-protein kinase 4.42e-05 1.00
MARK3_HUMAN MARK3 MAP/microtubule affinity-regulating kinase 3 5.104e-05 1.00
TNIK_HUMAN TNIK TRAF2 and NCK-interacting protein kinase 5.184e-05 1.00
RIPK1_HUMAN RIPK1 Receptor-interacting serine/threonine-protein kinase 1 6.503e-05 1.00
LTK_HUMAN LTK Leukocyte tyrosine kinase receptor 0.0001565 1.00
M4K5_HUMAN MAP4K5 Mitogen-activated protein kinase kinase kinase kinase 5 0.0001822 1.00
PLK4_HUMAN PLK4 Serine/threonine-protein kinase PLK4 0.0002443 1.00
NEK2_HUMAN NEK2 Serine/threonine-protein kinase Nek2 0.000289 1.00
TAOK1_HUMAN TAOK1 Serine/threonine-protein kinase TAO1 0.0003216 1.00
LIMK2_HUMAN LIMK2 LIM domain kinase 2 0.0003853 1.00
PI4KB_HUMAN PI4KB Phosphatidylinositol 4-kinase beta 0.0004689 1.00
M4K2_HUMAN MAP4K2 Mitogen-activated protein kinase kinase kinase kinase 2 0.0005759 1.00
MERTK_HUMAN MERTK Tyrosine-protein kinase Mer 0.0008578 1.00
M4K4_HUMAN MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4 0.001688 1.00
AURKB_HUMAN AURKB Aurora kinase B 0.002548 1.00
VGFR3_HUMAN FLT4 Vascular endothelial growth factor receptor 3 0.003937 1.00
HCK_HUMAN HCK Tyrosine-protein kinase HCK 0.007401 1.00
TIE2_HUMAN TEK Angiopoietin-1 receptor 0.007853 1.00
RET_HUMAN RET Proto-oncogene tyrosine-protein kinase receptor Ret 0.007969 1.00
ABL1_HUMAN ABL1 Tyrosine-protein kinase ABL1 0.01111 1.00
MK08_HUMAN MAPK8 Mitogen-activated protein kinase 8 0.01335 1.00
AURKA_HUMAN AURKA Aurora kinase A 0.01336 1.00
MK09_HUMAN MAPK9 Mitogen-activated protein kinase 9 0.01343 1.00
FAK1_HUMAN PTK2 Focal adhesion kinase 1 0.01486 1.00
LIMK1_HUMAN LIMK1 LIM domain kinase 1 0.02709 1.00
FGFR2_HUMAN FGFR2 Fibroblast growth factor receptor 2 0.03027 1.00
VGFR1_HUMAN FLT1 Vascular endothelial growth factor receptor 1 0.03181 1.00
TTK_HUMAN TTK Dual specificity protein kinase TTK 0.03182 1.00
ACK1_HUMAN TNK2 Activated CDC42 kinase 1 0.03267 1.00
TYK2_HUMAN TYK2 Non-receptor tyrosine-protein kinase TYK2 0.04365 1.00
MK10_HUMAN MAPK10 Mitogen-activated protein kinase 10 0.05631 1.00
IGF1R_HUMAN IGF1R Insulin-like growth factor 1 receptor 0.0998 1.00
CSF1R_HUMAN CSF1R Macrophage colony-stimulating factor 1 receptor 0.1023 1.00
FGFR3_HUMAN FGFR3 Fibroblast growth factor receptor 3 0.1098 1.00
FGFR4_HUMAN FGFR4 Fibroblast growth factor receptor 4 0.1563 1.00
ALK_HUMAN ALK ALK tyrosine kinase receptor 0.1922 1.00
JAK3_HUMAN JAK3 Tyrosine-protein kinase JAK3 0.1953 1.00
RAF1_HUMAN RAF1 RAF proto-oncogene serine/threonine-protein kinase 0.2081 1.00
FLT3_HUMAN FLT3 Receptor-type tyrosine-protein kinase FLT3 0.3221 1.00
JAK2_HUMAN JAK2 Tyrosine-protein kinase JAK2 0.7245 1.00
BRAF_HUMAN BRAF Serine/threonine-protein kinase B-raf 0.8498 1.00
MET_HUMAN MET Hepatocyte growth factor receptor 0.8627 1.00
ACES_HUMAN ACHE Acetylcholinesterase 0.9519 1.00
SMG1_HUMAN SMG1 Serine/threonine-protein kinase SMG1 5.596e-65 0.41
LCK_MOUSE Lck Proto-oncogene tyrosine-protein kinase LCK 2.34e-56 0.37
DKK1_HUMAN DKK1 Dickkopf-related protein 1 1.548e-37 0.35
EPHB4_HUMAN EPHB4 Ephrin type-B receptor 4 4.12e-24 0.39
BCR_HUMAN BCR Breakpoint cluster region protein 4.884e-19 0.30
CCNH_HUMAN CCNH Cyclin-H 1.998e-15 0.35
CDK2_HUMAN CDK2 Cyclin-dependent kinase 2 9.566e-10 0.37
RAC1_HUMAN RAC1 Ras-related C3 botulinum toxin substrate 1 1.072e-09 0.28
CCNB1_HUMAN CCNB1 G2/mitotic-specific cyclin-B1 9.361e-09 0.35
CSK_HUMAN CSK Tyrosine-protein kinase CSK 1.237e-07 0.35
COQ8B_HUMAN COQ8B Atypical kinase COQ8B, mitochondrial 1.964e-07 0.30
CDK1_HUMAN CDK1 Cyclin-dependent kinase 1 2.742e-07 0.37
CCNT1_HUMAN CCNT1 Cyclin-T1 4.249e-07 0.35
CCNA1_HUMAN CCNA1 Cyclin-A1 4.915e-07 0.31
MATK_HUMAN MATK Megakaryocyte-associated tyrosine-protein kinase 8.828e-07 0.37
PAK1_HUMAN PAK1 Serine/threonine-protein kinase PAK 1 1.126e-06 0.36

Amisulpride

DRD2_HUMAN DRD2 D(2) dopamine receptor 1.619e-22 1.00
DRD3_HUMAN DRD3 D(3) dopamine receptor 2.281e-11 1.00
5HT2B_HUMAN HTR2B 5-hydroxytryptamine receptor 2B 0.0283 1.00
5HT7R_HUMAN HTR7 5-hydroxytryptamine receptor 7 0.395 1.00
5HT2A_HUMAN HTR2A 5-hydroxytryptamine receptor 2A 0.9094 1.00
5HT4R_RAT Htr4 5-hydroxytryptamine receptor 4 7.395e-114 0.48
5HT4R_HUMAN HTR4 5-hydroxytryptamine receptor 4 1.076e-107 0.45
5HT4R_CAVPO HTR4 5-hydroxytryptamine receptor 4 9.147e-91 0.46
Q25856_PLAFA PFG6PD Glucose-6-phosphate dehydrogenase 2.703e-88 0.43
DRD2_CANLF DRD2 D(2) dopamine receptor 8.633e-82 0.66
GLUPH_PLAF7 Bifunctional glucose-6-phosphate 1-dehydrogenase/6-phosphogluconolactonase 3.078e-57 0.37
DRD2_RAT Drd2 D(2) dopamine receptor 1.131e-49 0.69
NLRP3_MOUSE Nlrp3 NACHT, LRR and PYD domains-containing protein 3 2.902e-32 0.32
SC5A7_HUMAN SLC5A7 High affinity choline transporter 1 6.743e-31 0.32
5HT3B_RAT Htr3b 5-hydroxytryptamine receptor 3B 1.38e-30 0.49
5HT3A_RAT Htr3a 5-hydroxytryptamine receptor 3A 7.197e-26 0.49
DRD1_BOVIN DRD1 D(1A) dopamine receptor 1.959e-25 0.36
DRD3_RAT Drd3 D(3) dopamine receptor 5.318e-24 0.50
DRD4_HUMAN DRD4 D(4) dopamine receptor 1.514e-17 0.66
GLMU_ECOLI glmU Bifunctional protein GlmU 1.11e-16 0.29
PDE5A_CANLF PDE5A cGMP-specific 3',5'-cyclic phosphodiesterase 1.11e-16 0.33
DRD3_CHLAE DRD3 D(3) dopamine receptor 1.91e-14 0.53
MIP_LEGPN mip Outer membrane protein MIP 7.936e-13 0.29
ABCBB_RAT Abcb11 Bile salt export pump 3.4e-12 0.30
MCHR2_HUMAN MCHR2 Melanin-concentrating hormone receptor 2 1.174e-11 0.42
5HT3A_HUMAN HTR3A 5-hydroxytryptamine receptor 3A 1.109e-10 0.35
PPIB_HUMAN PPIB Peptidyl-prolyl cis-trans isomerase B 1.272e-10 0.28
MTCA2_MYCTU mtcA2 Carbonic anhydrase 2 1.421e-10 0.66
Q5TU56_ANOGA 1272966 Carbonic anhydrase 7.381e-10 0.66
CAN_YEAST NCE103 Carbonic anhydrase 1.901e-09 0.66
ABCC8_HUMAN ABCC8 ATP-binding cassette sub-family C member 8 2.115e-09 0.30
DRD2_CHLAE DRD2 D(2) dopamine receptor 3.721e-09 0.53
PPIG_HUMAN PPIG Peptidyl-prolyl cis-trans isomerase G 4.053e-09 0.28
C0IX24_STYPI CA2 Carbonic anhydrase 4.441e-09 0.66
Q5U9J1_THAWE ca1 Delta carbonic anhydrase 4.441e-09 0.66
SMAD3_HUMAN SMAD3 Mothers against decapentaplegic homolog 3 4.816e-09 0.36
S15A2_RAT Slc15a2 Solute carrier family 15 member 2 6.237e-09 0.30
ACKR3_HUMAN ACKR3 Atypical chemokine receptor 3 7.163e-09 0.41
B2V8E3_SULSY Carbonate dehydratase 9.55e-09 0.66
B5SU02_STYPI CA Alpha carbonic anhydrase 9.55e-09 0.66
Q31FD6_HYDCU Carbonic anhydrase, alpha family 9.55e-09 0.66
A6YCJ1_9METZ Astrosclerin-3 2.649e-08 0.66
DPOL_HHV6U U38 DNA polymerase catalytic subunit 3.985e-08 0.29
S22A6_RAT Slc22a6 Solute carrier family 22 member 6 5.293e-08 0.30
CYNT_HELPY cynT Carbonic anhydrase 1.426e-07 0.66
DPP9_HUMAN DPP9 Dipeptidyl peptidase 9 3.322e-07 0.34
5HT1A_RAT Htr1a 5-hydroxytryptamine receptor 1A 6.107e-07 0.57
ACH10_RAT Chrna10 Neuronal acetylcholine receptor subunit alpha-10 7.219e-07 0.32
ENV_HV1Y2 env Envelope glycoprotein gp160 8.872e-07 0.41
OPRX_CAVPO OPRL1 Nociceptin receptor 2.088e-06 0.29
Q3I4V7_CRYNV CAN2 Carbonic anhydrase 6.972e-06 0.66

Ezogabine

KCNQ2_MOUSE Kcnq2 Potassium voltage-gated channel subfamily KQT member 2 6.843e-21 1.00
KCNQ2_HUMAN KCNQ2 Potassium voltage-gated channel subfamily KQT member 2 2.942e-10 1.00
TF7L2_HUMAN TCF7L2 Transcription factor 7-like 2 4.463e-148 0.39
CTNB1_HUMAN CTNNB1 Catenin beta-1 1.491e-136 0.39
CCR1_MOUSE Ccr1 C-C chemokine receptor type 1 3.541e-67 0.33
DRTS_TRYCR Bifunctional dihydrofolate reductase-thymidylate synthase 1.028e-61 0.35
NR1I3_HUMAN NR1I3 Nuclear receptor subfamily 1 group I member 3 2.433e-50 0.34
NCOR1_HUMAN NCOR1 Nuclear receptor corepressor 1 1.09e-43 0.33
DYR_ENTFC folA Dihydrofolate reductase 2.979e-41 0.37
ENOA_HUMAN ENO1 Alpha-enolase 6.045e-41 0.32
UBP10_HUMAN USP10 Ubiquitin carboxyl-terminal hydrolase 10 4.749e-37 0.29
UBP13_HUMAN USP13 Ubiquitin carboxyl-terminal hydrolase 13 4.749e-37 0.29
CXCR4_RAT Cxcr4 C-X-C chemokine receptor type 4 4.831e-37 0.35
Q9JLY8_RAT Ccr1 C-C motif chemokine receptor 1 3.062e-35 0.33
PPID_HUMAN PPID Peptidyl-prolyl cis-trans isomerase D 1.777e-29 0.37
HDAC1_HUMAN HDAC1 Histone deacetylase 1 6.204e-27 0.44
LEF_BACAN lef Lethal factor 8.971e-26 0.36
Q9NBD4_PLAFA Cysteine protease falcipain-2 9.719e-24 0.29
KCNH3_HUMAN KCNH3 Potassium voltage-gated channel subfamily H member 3 9.456e-22 0.35
HDAC2_HUMAN HDAC2 Histone deacetylase 2 9.609e-22 0.44
Q76353_9HIV1 Integrase 1.968e-21 0.36
HDAC1_MOUSE Hdac1 Histone deacetylase 1 4.935e-21 0.35
DRTS_LEIMA Bifunctional dihydrofolate reductase-thymidylate synthase 2.042e-19 0.35
HDAC3_HUMAN HDAC3 Histone deacetylase 3 2.811e-18 0.43
LOX15_HUMAN ALOX15 Arachidonate 15-lipoxygenase 3.339e-18 0.35
CCR1_HUMAN CCR1 C-C chemokine receptor type 1 1.11e-16 0.33
PYGM_RAT Pygm Glycogen phosphorylase, muscle form 6.661e-16 0.30
PTR1_LEIMA PTR1 Pteridine reductase 1 4.574e-14 0.35
FFAR1_HUMAN FFAR1 Free fatty acid receptor 1 4.752e-14 0.35
STA5A_HUMAN STAT5A Signal transducer and activator of transcription 5A 2.001e-13 0.31
PPIB_HUMAN PPIB Peptidyl-prolyl cis-trans isomerase B 1.551e-12 0.34
DYR_RAT Dhfr Dihydrofolate reductase 3.485e-12 0.37
Q7ZJM1_9HIV1 pol Integrase 2.83e-11 0.33
RIPK1_HUMAN RIPK1 Receptor-interacting serine/threonine-protein kinase 1 4.453e-11 0.33
VGFR1_HUMAN FLT1 Vascular endothelial growth factor receptor 1 1.924e-10 0.34
BLK_HUMAN BLK Tyrosine-protein kinase Blk 2.906e-10 0.32
ELOV6_HUMAN ELOVL6 Elongation of very long chain fatty acids protein 6 3.246e-10 0.35
TLR4_HUMAN TLR4 Toll-like receptor 4 4.532e-10 0.31
FFAR1_RAT Ffar1 Free fatty acid receptor 1 6.879e-10 0.32
PPARD_MOUSE Ppard Peroxisome proliferator-activated receptor delta 9.455e-10 0.31
FAAH1_HUMAN FAAH Fatty-acid amide hydrolase 1 1.618e-09 0.39
PYRD_HUMAN DHODH Dihydroorotate dehydrogenase (quinone), mitochondrial 2.07e-09 0.34
PPARA_MOUSE Ppara Peroxisome proliferator-activated receptor alpha 2.402e-09 0.31
ST32B_HUMAN STK32B Serine/threonine-protein kinase 32B 3.781e-09 0.31
STA5B_HUMAN STAT5B Signal transducer and activator of transcription 5B 4.004e-09 0.31
VGFR2_HUMAN KDR Vascular endothelial growth factor receptor 2 9.965e-09 0.40
PPBI_BOVIN ALPI Intestinal-type alkaline phosphatase 1.148e-08 0.31
LYN_HUMAN LYN Tyrosine-protein kinase Lyn 1.201e-08 0.32
REV1_HUMAN REV1 DNA repair protein REV1 1.743e-08 0.32
SMN_HUMAN SMN1; SMN2 Survival motor neuron protein 2.026e-08 0.29
KIT_HUMAN KIT Mast/stem cell growth factor receptor Kit 3.025e-08 0.32
VGFR3_HUMAN FLT4 Vascular endothelial growth factor receptor 3 3.067e-08 0.32
MET_HUMAN MET Hepatocyte growth factor receptor 3.26e-08 0.36
NLK_HUMAN NLK Serine/threonine-protein kinase NLK 3.789e-08 0.32
EGFR_MOUSE Egfr Epidermal growth factor receptor 4.403e-08 0.33
CD11A_HUMAN CDK11A Cyclin-dependent kinase 11A 8.23e-08 0.31
CDK13_HUMAN CDK13 Cyclin-dependent kinase 13 8.23e-08 0.31
MRCKG_HUMAN CDC42BPG Serine/threonine-protein kinase MRCK gamma 8.23e-08 0.31
MYO3B_HUMAN MYO3B Myosin-IIIb 8.23e-08 0.31
ST32A_HUMAN STK32A Serine/threonine-protein kinase 32A 8.23e-08 0.31
TAAR1_RAT Taar1 Trace amine-associated receptor 1 1.152e-07 0.37
PPBT_BOVIN ALPL Alkaline phosphatase, tissue-nonspecific isozyme 1.313e-07 0.31
LCAP_HUMAN LNPEP Leucyl-cystinyl aminopeptidase 1.867e-07 0.33
ANDR_RAT Ar Androgen receptor 2.168e-07 0.32
Q25270_LEIDO beta-tubulin Beta-tubulin 2.229e-07 0.34
TRPV1_RAT Trpv1 Transient receptor potential cation channel subfamily V member 1 2.483e-07 0.36
THB_RAT Thrb Thyroid hormone receptor beta 4.531e-07 0.30
CD11B_HUMAN CDK11B Cyclin-dependent kinase 11B 6.705e-07 0.31
LATS1_HUMAN LATS1 Serine/threonine-protein kinase LATS1 6.705e-07 0.31
SGK3_HUMAN SGK3 Serine/threonine-protein kinase Sgk3 6.705e-07 0.31
Q862F3_BOVIN Similar to alpha-tubulin isoform 1 7.176e-07 0.30
PLEC_HUMAN PLEC Plectin 8.349e-07 0.34
PSBA_SPIOL psbA Photosystem II protein D1 9.246e-07 0.32
HYES_HUMAN EPHX2 Bifunctional epoxide hydrolase 2 1.007e-06 0.39
HDAC8_HUMAN HDAC8 Histone deacetylase 8 1.492e-06 0.34
Q54A96_PLAFA dhod Dihydroorotate dehydrogenase 1.724e-06 0.33
FUCO_RAT Fuca1 Tissue alpha-L-fucosidase 2.324e-06 0.30
FLT3_HUMAN FLT3 Receptor-type tyrosine-protein kinase FLT3 2.484e-06 0.36
FFAR4_HUMAN FFAR4 Free fatty acid receptor 4 2.582e-06 0.32
C3TDZ2_ECOLX fabH 3-oxoacyl-[acyl-carrier-protein] synthase 3 2.933e-06 0.33
LDLR_HUMAN LDLR Low-density lipoprotein receptor 3.105e-06 0.28
INSRR_HUMAN INSRR Insulin receptor-related protein 3.124e-06 0.31
SENP1_HUMAN SENP1 Sentrin-specific protease 1 3.133e-06 0.28
PDE6A_BOVIN PDE6A Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha 3.773e-06 0.34
KCNJ6_HUMAN KCNJ6 G protein-activated inward rectifier potassium channel 2 4.146e-06 0.36
TAAR1_MOUSE Taar1 Trace amine-associated receptor 1 4.638e-06 0.37
FYN_HUMAN FYN Tyrosine-protein kinase Fyn 4.782e-06 0.32
LATS2_HUMAN LATS2 Serine/threonine-protein kinase LATS2 4.793e-06 0.31
BRAF_HUMAN BRAF Serine/threonine-protein kinase B-raf 4.87e-06 0.32
Q9WKE8_9HIV1 reverse transcriptase Reverse transcriptase 5.159e-06 0.35
TRYB1_HUMAN TPSAB1 Tryptase alpha/beta-1 5.333e-06 0.30
RXFP1_HUMAN RXFP1 Relaxin receptor 1 6.798e-06 0.30
LYOX_HUMAN LOX Protein-lysine 6-oxidase 7.112e-06 0.29
FRK_HUMAN FRK Tyrosine-protein kinase FRK 8.857e-06 0.32
SC5A5_RAT Slc5a5 Sodium/iodide cotransporter 8.882e-06 0.31
FOLC_HUMAN FPGS Folylpolyglutamate synthase, mitochondrial 9.885e-06 0.29
BRAF_MOUSE Braf Serine/threonine-protein kinase B-raf 9.96e-06 0.30

Tirbanibulin

SRC_HUMAN SRC Proto-oncogene tyrosine-protein kinase Src 1.652e-19 1.00
LKHA4_HUMAN LTA4H Leukotriene A-4 hydrolase 2.462e-96 0.52
ESR1_HUMAN ESR1 Estrogen receptor 1.181e-65 0.43
ESR2_HUMAN ESR2 Estrogen receptor beta 1.764e-57 0.42
G3I1B6_CRIGR 5-hydroxytryptamine receptor 4.669e-57 0.35
5HT1B_CRIGR HTR1B 5-hydroxytryptamine receptor 1B 2.274e-56 0.35
GPC6A_MOUSE Gprc6a G-protein coupled receptor family C group 6 member A 3.521e-55 0.32
Q6A2E2_AEDAE ace-1 Acetylcholinesterase 5.818e-54 0.39
PTGDS_MOUSE Ptgds Prostaglandin-H2 D-isomerase 2.835e-52 0.36
SMS1_HUMAN SGMS1 Phosphatidylcholine:ceramide cholinephosphotransferase 1 1.687e-48 0.31
V1BR_HUMAN AVPR1B Vasopressin V1b receptor 2.22e-44 0.40
HRH3_HUMAN HRH3 Histamine H3 receptor 3.282e-44 0.46
PSB1_HUMAN PSMB1 Proteasome subunit beta type-1 4.332e-44 0.43
BMP4_HUMAN BMP4 Bone morphogenetic protein 4 1.132e-43 0.42
NK2R_HUMAN TACR2 Substance-K receptor 2.221e-41 0.41
MCHR1_MOUSE Mchr1 Melanin-concentrating hormone receptor 1 2.257e-38 0.35
PAQR1_HUMAN ADIPOR1 Adiponectin receptor protein 1 3.17e-38 0.30
PAQR2_HUMAN ADIPOR2 Adiponectin receptor protein 2 3.17e-38 0.30
HRH3_RAT Hrh3 Histamine H3 receptor 5.088e-38 0.46
LKHA4_MOUSE Lta4h Leukotriene A-4 hydrolase 1.574e-36 0.33
ADA17_PIG ADAM17 Disintegrin and metalloproteinase domain-containing protein 17 2.437e-36 0.33
ACK1_MOUSE Tnk2 Activated CDC42 kinase 1 2.006e-32 0.39
CASR_HUMAN CASR Extracellular calcium-sensing receptor 5.681e-32 0.33
NORA_STAAU norA Quinolone resistance protein NorA 1.178e-30 0.38
PSB2_HUMAN PSMB2 Proteasome subunit beta type-2 8.925e-30 0.35
CHLE_HORSE BCHE Cholinesterase 2.235e-29 0.36
DPOL_HHV11 DNA polymerase catalytic subunit 1.6e-28 0.33
DPOL_VZVD DNA polymerase catalytic subunit 1.6e-28 0.33
5HT7R_HUMAN HTR7 5-hydroxytryptamine receptor 7 1.768e-28 0.54
ESR1_RAT Esr1 Estrogen receptor 6.273e-28 0.34
HNMT_RAT Hnmt Histamine N-methyltransferase 1.173e-27 0.32
ACES_ELEEL ache Acetylcholinesterase 1.68e-27 0.38
KLK1_HUMAN KLK1 Kallikrein-1 5.6e-27 0.32
HRH1_CAVPO HRH1 Histamine H1 receptor 1.64e-26 0.33
HRH3_CAVPO HRH3 Histamine H3 receptor 1.703e-26 0.43
IMA1_HUMAN KPNA2 Importin subunit alpha-1 6.795e-26 0.32
HYES_HUMAN EPHX2 Bifunctional epoxide hydrolase 2 1.459e-25 0.53
AP2S1_RAT Ap2s1 AP-2 complex subunit sigma 1.842e-25 0.31
SCRB1_HUMAN SCARB1 Scavenger receptor class B member 1 2.965e-25 0.32
NR1H4_MOUSE Nr1h4 Bile acid receptor 3.932e-25 0.36
ADCY5_RAT Adcy5 Adenylate cyclase type 5 6.518e-24 0.33
5HT1A_HUMAN HTR1A 5-hydroxytryptamine receptor 1A 2.559e-23 0.54
Q9X688_CAUVI cckA Cell cycle histidine kinase CckA 3.817e-23 0.28
PA24A_BOVIN PLA2G4A Cytosolic phospholipase A2 8.368e-23 0.33
FLT3_HUMAN FLT3 Receptor-type tyrosine-protein kinase FLT3 9.85e-23 0.53
KLKB1_HUMAN KLKB1 Plasma kallikrein 2.21e-22 0.33
NMT2_HUMAN NMT2 Glycylpeptide N-tetradecanoyltransferase 2 2.157e-21 0.34
USP9X_HUMAN USP9X Probable ubiquitin carboxyl-terminal hydrolase FAF-X 2.411e-21 0.34
MK14_MOUSE Mapk14 Mitogen-activated protein kinase 14 2.671e-21 0.39
MK14_HUMAN MAPK14 Mitogen-activated protein kinase 14 5.45e-21 0.39
CNR1_RAT Cnr1 Cannabinoid receptor 1 9.725e-21 0.36
AUKBA_XENLA aurkb-a Aurora kinase B-A 1.878e-20 0.33
ESR2_RAT Esr2 Estrogen receptor beta 1.994e-20 0.33
UBC9_HUMAN UBE2I SUMO-conjugating enzyme UBC9 2.215e-20 0.31
HRH1_HUMAN HRH1 Histamine H1 receptor 3.006e-20 0.41
PSB5_HUMAN PSMB5 Proteasome subunit beta type-5 4.262e-20 0.43
CHLE_HUMAN BCHE Cholinesterase 2.615e-19 0.36
A5A4K8_RABIT MLNR Motilin receptor 8.774e-19 0.35
5HT7R_CAVPO HTR7 5-hydroxytryptamine receptor 7 1.057e-18 0.33
AOC3_HUMAN AOC3 Membrane primary amine oxidase 1.313e-18 0.36
HPGDS_HUMAN HPGDS Hematopoietic prostaglandin D synthase 3.639e-18 0.42
TBK1_HUMAN TBK1 Serine/threonine-protein kinase TBK1 4.432e-18 0.42
GSK3A_HUMAN GSK3A Glycogen synthase kinase-3 alpha 4.996e-18 0.34
SGMR1_HUMAN SIGMAR1 Sigma non-opioid intracellular receptor 1 5.013e-18 0.39
TRPV4_HUMAN TRPV4 Transient receptor potential cation channel subfamily V member 4 7.086e-18 0.34
SCNAA_MOUSE Scn10a Sodium channel protein type 10 subunit alpha 8.433e-18 0.35
KDM1B_HUMAN KDM1B Lysine-specific histone demethylase 1B 9.507e-18 0.28
ATS1_HUMAN ADAMTS1 A disintegrin and metalloproteinase with thrombospondin motifs 1 1.882e-17 0.33
KS6A1_HUMAN RPS6KA1 Ribosomal protein S6 kinase alpha-1 2.068e-17 0.43
HRH2_HUMAN HRH2 Histamine H2 receptor 2.399e-17 0.35
PRKDC_HUMAN PRKDC DNA-dependent protein kinase catalytic subunit 2.629e-17 0.36
CSN5_HUMAN COPS5 COP9 signalosome complex subunit 5 4.372e-17 0.31
AURKA_HUMAN AURKA Aurora kinase A 1.11e-16 0.53
AURKB_HUMAN AURKB Aurora kinase B 1.11e-16 0.46
CCR4_HUMAN CCR4 C-C chemokine receptor type 4 1.11e-16 0.35
CLTR1_CAVPO CYSLTR1 Cysteinyl leukotriene receptor 1 1.11e-16 0.38
PSB8_HUMAN PSMB8 Proteasome subunit beta type-8 1.11e-16 0.33
TLR9_HUMAN TLR9 Toll-like receptor 9 1.11e-16 0.32
ACK1_HUMAN TNK2 Activated CDC42 kinase 1 2.22e-16 0.40
CLTR1_HUMAN CYSLTR1 Cysteinyl leukotriene receptor 1 2.22e-16 0.38
ADA17_HUMAN ADAM17 Disintegrin and metalloproteinase domain-containing protein 17 3.331e-16 0.37
ADA33_HUMAN ADAM33 Disintegrin and metalloproteinase domain-containing protein 33 3.331e-16 0.33
GYRB_MYCSM gyrB DNA gyrase subunit B 3.331e-16 0.46
PPARA_HUMAN PPARA Peroxisome proliferator-activated receptor alpha 3.331e-16 0.34
PPARG_HUMAN PPARG Peroxisome proliferator-activated receptor gamma 5.551e-16 0.43
DRD2_HUMAN DRD2 D(2) dopamine receptor 1.443e-15 0.54
RAF1_MOUSE Raf1 RAF proto-oncogene serine/threonine-protein kinase 8.105e-15 0.28
STAT6_HUMAN STAT6 Signal transducer and activator of transcription 6 8.993e-15 0.34
SGMR1_CAVPO SIGMAR1 Sigma non-opioid intracellular receptor 1 1.077e-14 0.42
ALBU_HUMAN ALB Serum albumin 1.099e-14 0.34
VGFR2_HUMAN KDR Vascular endothelial growth factor receptor 2 1.188e-14 0.53
LCK_HUMAN LCK Tyrosine-protein kinase Lck 1.776e-14 0.43
ACHA7_RAT Chrna7 Neuronal acetylcholine receptor subunit alpha-7 2.01e-14 0.43
MCHR1_HUMAN MCHR1 Melanin-concentrating hormone receptor 1 2.287e-14 0.44
Q9HUN3_PSEAE dnaB Replicative DNA helicase 2.975e-14 0.31
PORCN_HUMAN PORCN Protein-serine O-palmitoleoyltransferase porcupine 3.786e-14 0.35
MET_HUMAN MET Hepatocyte growth factor receptor 3.864e-14 0.43
MMP13_HUMAN MMP13 Collagenase 3 4.052e-14 0.40
MKNK1_HUMAN MKNK1 MAP kinase-interacting serine/threonine-protein kinase 1 4.663e-14 0.43
ROCK2_RAT Rock2 Rho-associated protein kinase 2 5.129e-14 0.29
VE1_HPV11 E1 Replication protein E1 5.373e-14 0.36
ACES_HUMAN ACHE Acetylcholinesterase 6.35e-14 0.44
NMD3A_RAT Grin3a Glutamate receptor ionotropic, NMDA 3A 1.801e-13 0.40
KCNA5_HUMAN KCNA5 Potassium voltage-gated channel subfamily A member 5 3.377e-13 0.41
HSPB1_HUMAN HSPB1 Heat shock protein beta-1 5.514e-13 0.35
PDS_SYNE7 pds 15-cis-phytoene desaturase 6.546e-13 0.32
ACOD1_MOUSE Scd1 Acyl-CoA desaturase 1 7.278e-13 0.34
CNR2_HUMAN CNR2 Cannabinoid receptor 2 8.996e-13 0.45
SUCR1_HUMAN SUCNR1 Succinate receptor 1 9.013e-13 0.33
CAC1G_HUMAN CACNA1G Voltage-dependent T-type calcium channel subunit alpha-1G 1.114e-12 0.34
VGFR1_HUMAN FLT1 Vascular endothelial growth factor receptor 1 1.606e-12 0.53
SGMR2_RAT Tmem97 Sigma intracellular receptor 2 2.275e-12 0.35
ROCK1_HUMAN ROCK1 Rho-associated protein kinase 1 2.304e-12 0.43
ATS5_HUMAN ADAMTS5 A disintegrin and metalloproteinase with thrombospondin motifs 5 2.627e-12 0.37
LPXC_PSEAE lpxC UDP-3-O-acyl-N-acetylglucosamine deacetylase 2.673e-12 0.44
5HT7R_RAT Htr7 5-hydroxytryptamine receptor 7 2.697e-12 0.36
PORCN_MOUSE Porcn Protein-serine O-palmitoleoyltransferase porcupine 3.438e-12 0.31
NAMPT_HUMAN NAMPT Nicotinamide phosphoribosyltransferase 3.91e-12 0.34
PE2R4_HUMAN PTGER4 Prostaglandin E2 receptor EP4 subtype 4.485e-12 0.38
ROCK2_HUMAN ROCK2 Rho-associated protein kinase 2 4.695e-12 0.38
PDE10_RAT Pde10a cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 7.752e-12 0.36
IKKE_HUMAN IKBKE Inhibitor of nuclear factor kappa-B kinase subunit epsilon 9.255e-12 0.33
LUCI_AQULA Luciferin 4-monooxygenase 9.818e-12 0.32
MMP9_HUMAN MMP9 Matrix metalloproteinase-9 1.471e-11 0.40
MMP12_HUMAN MMP12 Macrophage metalloelastase 1.871e-11 0.40
MUSK_HUMAN MUSK Muscle, skeletal receptor tyrosine-protein kinase 1.919e-11 0.35
PDE1A_HUMAN PDE1A Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2.252e-11 0.32
MK08_HUMAN MAPK8 Mitogen-activated protein kinase 8 2.603e-11 0.35
NK2R_CAVPO TACR2 Substance-K receptor 2.905e-11 0.29
AOFA_RAT Maoa Amine oxidase [flavin-containing] A 3.017e-11 0.36
YES_HUMAN YES1 Tyrosine-protein kinase Yes 3.038e-11 0.35
STABP_HUMAN STAMBP STAM-binding protein 4.317e-11 0.31
SCN2A_HUMAN SCN2A Sodium channel protein type 2 subunit alpha 4.856e-11 0.35
DRD3_HUMAN DRD3 D(3) dopamine receptor 6.137e-11 0.32
DDR2_HUMAN DDR2 Discoidin domain-containing receptor 2 6.852e-11 0.38
Q9NBA7_PLAFA Cysteine protease falcipain-3 7.43e-11 0.29
MMP3_HUMAN MMP3 Stromelysin-1 9.853e-11 0.35
PK3CA_HUMAN PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 1.493e-10 0.40
GP183_MOUSE Gpr183 G-protein coupled receptor 183 1.559e-10 0.30
FAAH1_HUMAN FAAH Fatty-acid amide hydrolase 1 1.703e-10 0.35
AOC3_RAT Aoc3 Membrane primary amine oxidase 1.731e-10 0.33
AAKB1_HUMAN PRKAB1 5'-AMP-activated protein kinase subunit beta-1 2.043e-10 0.49
EPHA3_HUMAN EPHA3 Ephrin type-A receptor 3 2.308e-10 0.36
MK15_HUMAN MAPK15 Mitogen-activated protein kinase 15 2.322e-10 0.35
NAC1_HUMAN SLC8A1 Sodium/calcium exchanger 1 2.674e-10 0.34
SCNAA_HUMAN SCN10A Sodium channel protein type 10 subunit alpha 2.878e-10 0.35
EPHA7_HUMAN EPHA7 Ephrin type-A receptor 7 3.947e-10 0.35
EZH2_HUMAN EZH2 Histone-lysine N-methyltransferase EZH2 4.121e-10 0.33
CBP_HUMAN CREBBP CREB-binding protein 4.169e-10 0.31
HSP12_CAEEL hsp-16.2 Heat shock protein Hsp-16.2 4.325e-10 0.29
CATK_MOUSE Ctsk Cathepsin K 5.242e-10 0.29
Q6DMN0_TOXGO CPL Cathepsin L 5.242e-10 0.29
HDAC1_HUMAN HDAC1 Histone deacetylase 1 5.327e-10 0.47
SC5A7_HUMAN SLC5A7 High affinity choline transporter 1 6.101e-10 0.35
TRPV4_MOUSE Trpv4 Transient receptor potential cation channel subfamily V member 4 6.69e-10 0.29
KCNJ3_RAT Kcnj3 G protein-activated inward rectifier potassium channel 1 6.735e-10 0.31
KCNJ5_RAT Kcnj5 G protein-activated inward rectifier potassium channel 4 6.735e-10 0.31
MTOR_HUMAN MTOR Serine/threonine-protein kinase mTOR 6.737e-10 0.36
CCKAR_MOUSE Cckar Cholecystokinin receptor type A 6.938e-10 0.30
AOFB_HUMAN MAOB Amine oxidase [flavin-containing] B 7.094e-10 0.35
ACES_ANOGA Ace Acetylcholinesterase 9.88e-10 0.39
CLTR2_HUMAN CYSLTR2 Cysteinyl leukotriene receptor 2 1.038e-09 0.31
PPCE_BOVIN PREP Prolyl endopeptidase 1.147e-09 0.30
KSYK_HUMAN SYK Tyrosine-protein kinase SYK 1.236e-09 0.37
MK09_HUMAN MAPK9 Mitogen-activated protein kinase 9 1.357e-09 0.38
CNOT7_HUMAN CNOT7 CCR4-NOT transcription complex subunit 7 1.409e-09 0.34
LIPE_HUMAN LIPG Endothelial lipase 1.564e-09 0.39
ERCC1_HUMAN ERCC1 DNA excision repair protein ERCC-1 1.917e-09 0.35
XPF_HUMAN ERCC4 DNA repair endonuclease XPF 1.917e-09 0.35
ERN1_HUMAN ERN1 Serine/threonine-protein kinase/endoribonuclease IRE1 2.2e-09 0.33
CATL1_MOUSE Ctsl Cathepsin L1 2.569e-09 0.29
CATS_RAT Ctss Cathepsin S 2.569e-09 0.29
KCNH2_HUMAN KCNH2 Potassium voltage-gated channel subfamily H member 2 2.678e-09 0.38
PSDE_HUMAN PSMD14 26S proteasome non-ATPase regulatory subunit 14 3.485e-09 0.34
MK01_HUMAN MAPK1 Mitogen-activated protein kinase 1 3.981e-09 0.47
MOT4_HUMAN SLC16A3 Monocarboxylate transporter 4 4.099e-09 0.28
HRH2_RAT Hrh2 Histamine H2 receptor 4.366e-09 0.29
5HT4R_HUMAN HTR4 5-hydroxytryptamine receptor 4 5.071e-09 0.36
5HT2A_HUMAN HTR2A 5-hydroxytryptamine receptor 2A 5.185e-09 0.36
GLSK_HUMAN GLS Glutaminase kidney isoform, mitochondrial 5.434e-09 0.45
CNR1_HUMAN CNR1 Cannabinoid receptor 1 6.1e-09 0.45
LOX15_RAT Alox15 Arachidonate 15-lipoxygenase 6.847e-09 0.31
CDK13_HUMAN CDK13 Cyclin-dependent kinase 13 6.876e-09 0.35
MRCKB_HUMAN CDC42BPB Serine/threonine-protein kinase MRCK beta 6.876e-09 0.35
MRCKG_HUMAN CDC42BPG Serine/threonine-protein kinase MRCK gamma 6.876e-09 0.35
ELAS_PSEAE lasB Elastase 7.544e-09 0.29
MP2K1_HUMAN MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 7.619e-09 0.35
AOFB_RAT Maob Amine oxidase [flavin-containing] B 8.559e-09 0.36
M4K5_HUMAN MAP4K5 Mitogen-activated protein kinase kinase kinase kinase 5 8.625e-09 0.34
ABL1_MOUSE Abl1 Tyrosine-protein kinase ABL1 9.085e-09 0.38
CATB_MOUSE Ctsb Cathepsin B 9.651e-09 0.29
MMP1_HUMAN MMP1 Interstitial collagenase 1.061e-08 0.40
CAN2_HUMAN CAPN2 Calpain-2 catalytic subunit 1.074e-08 0.32
GSK3B_HUMAN GSK3B Glycogen synthase kinase-3 beta 1.079e-08 0.37
KIT_HUMAN KIT Mast/stem cell growth factor receptor Kit 1.094e-08 0.38
PA24A_HUMAN PLA2G4A Cytosolic phospholipase A2 1.233e-08 0.34
CTRO_HUMAN CIT Citron Rho-interacting kinase 1.513e-08 0.35
TNKS2_HUMAN TNKS2 Poly [ADP-ribose] polymerase tankyrase-2 1.54e-08 0.33
EPHA6_HUMAN EPHA6 Ephrin type-A receptor 6 1.572e-08 0.35
MMP2_HUMAN MMP2 72 kDa type IV collagenase 1.865e-08 0.34
PGFRB_HUMAN PDGFRB Platelet-derived growth factor receptor beta 2.07e-08 0.37
LYAM2_HUMAN SELE E-selectin 2.553e-08 0.34
KDM1A_HUMAN KDM1A Lysine-specific histone demethylase 1A 2.707e-08 0.41
CHK1_HUMAN CHEK1 Serine/threonine-protein kinase Chk1 2.73e-08 0.40
SLK_HUMAN SLK STE20-like serine/threonine-protein kinase 3.509e-08 0.35
TIE1_HUMAN TIE1 Tyrosine-protein kinase receptor Tie-1 3.942e-08 0.35
PA2GA_HUMAN PLA2G2A Phospholipase A2, membrane associated 5.145e-08 0.30
MMP8_HUMAN MMP8 Neutrophil collagenase 5.338e-08 0.34
THB_HUMAN THRB Thyroid hormone receptor beta 6.261e-08 0.39
MDR1_HUMAN ABCB1 ATP-dependent translocase ABCB1 6.33e-08 0.38
EPHA2_HUMAN EPHA2 Ephrin type-A receptor 2 6.584e-08 0.43
5HT3A_RAT Htr3a 5-hydroxytryptamine receptor 3A 7.491e-08 0.32
CSF1R_MOUSE Csf1r Macrophage colony-stimulating factor 1 receptor 7.754e-08 0.30
5HT2A_RAT Htr2a 5-hydroxytryptamine receptor 2A 1.079e-07 0.33
TGFR2_HUMAN TGFBR2 TGF-beta receptor type-2 1.091e-07 0.32
CD11B_HUMAN CDK11B Cyclin-dependent kinase 11B 1.14e-07 0.34
HDAC2_HUMAN HDAC2 Histone deacetylase 2 1.467e-07 0.37
UR2R_HUMAN UTS2R Urotensin-2 receptor 1.61e-07 0.33
DRD4_RAT Drd4 D(4) dopamine receptor 1.813e-07 0.31
DGAT1_HUMAN DGAT1 Diacylglycerol O-acyltransferase 1 1.912e-07 0.33
FAAH1_RAT Faah Fatty-acid amide hydrolase 1 2.158e-07 0.39
EGFR_HUMAN EGFR Epidermal growth factor receptor 2.258e-07 0.46
MK10_HUMAN MAPK10 Mitogen-activated protein kinase 10 2.299e-07 0.35
Q9RMS5_PSEAI phzR LuxR family transcriptional regulator 2.362e-07 0.29
MCL1_HUMAN MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 2.691e-07 0.40
CP3A4_HUMAN CYP3A4 Cytochrome P450 3A4 2.752e-07 0.38
JAK3_HUMAN JAK3 Tyrosine-protein kinase JAK3 2.879e-07 0.38
GSTO1_HUMAN GSTO1 Glutathione S-transferase omega-1 2.996e-07 0.30
CSF1R_HUMAN CSF1R Macrophage colony-stimulating factor 1 receptor 3.064e-07 0.35
RCOR1_HUMAN RCOR1 REST corepressor 1 3.172e-07 0.29
GYRB_MYCS2 gyrB DNA gyrase subunit B 3.244e-07 0.31
HSF1_HUMAN HSF1 Heat shock factor protein 1 3.308e-07 0.36
RET_HUMAN RET Proto-oncogene tyrosine-protein kinase receptor Ret 3.32e-07 0.35
ACVR1_HUMAN ACVR1 Activin receptor type-1 3.343e-07 0.49
HRH3_MOUSE Hrh3 Histamine H3 receptor 4.062e-07 0.35
KMO_HUMAN KMO Kynurenine 3-monooxygenase 4.276e-07 0.37
STK10_HUMAN STK10 Serine/threonine-protein kinase 10 4.322e-07 0.35
THA_HUMAN THRA Thyroid hormone receptor alpha 4.867e-07 0.39
RAD52_HUMAN RAD52 DNA repair protein RAD52 homolog 5.284e-07 0.34
MAPK2_HUMAN MAPKAPK2 MAP kinase-activated protein kinase 2 6.084e-07 0.35
PDE1C_HUMAN PDE1C Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C 7.664e-07 0.32
5HT1A_RAT Htr1a 5-hydroxytryptamine receptor 1A 7.706e-07 0.35
HIPK4_HUMAN HIPK4 Homeodomain-interacting protein kinase 4 7.74e-07 0.33
VGFR3_HUMAN FLT4 Vascular endothelial growth factor receptor 3 7.795e-07 0.35
ACOD_HUMAN SCD Acyl-CoA desaturase 7.875e-07 0.34
TRPA1_RAT Trpa1 Transient receptor potential cation channel subfamily A member 1 7.899e-07 0.34
ATS4_HUMAN ADAMTS4 A disintegrin and metalloproteinase with thrombospondin motifs 4 7.925e-07 0.35
DPOL_HCMVA UL54 DNA polymerase catalytic subunit 8.012e-07 0.33
CATS_HUMAN CTSS Cathepsin S 8.306e-07 0.35
STA5A_HUMAN STAT5A Signal transducer and activator of transcription 5A 8.619e-07 0.29
MMP7_HUMAN MMP7 Matrilysin 9.066e-07 0.33
PLPL6_MOUSE Pnpla6 Neuropathy target esterase 9.396e-07 0.29
5HT6R_HUMAN HTR6 5-hydroxytryptamine receptor 6 9.859e-07 0.54
RPA1_HUMAN POLR1A DNA-directed RNA polymerase I subunit RPA1 9.875e-07 0.33
ADRM1_HUMAN ADRM1 Proteasomal ubiquitin receptor ADRM1 1.071e-06 0.30
PRS10_HUMAN PSMC6 26S proteasome regulatory subunit 10B 1.071e-06 0.30
PRS4_HUMAN PSMC1 26S proteasome regulatory subunit 4 1.071e-06 0.30
PRS6A_HUMAN PSMC3 26S proteasome regulatory subunit 6A 1.071e-06 0.30
PRS6B_HUMAN PSMC4 26S proteasome regulatory subunit 6B 1.071e-06 0.30
PRS7_HUMAN PSMC2 26S proteasome regulatory subunit 7 1.071e-06 0.30
PRS8_HUMAN PSMC5 26S proteasome regulatory subunit 8 1.071e-06 0.30
PSD11_HUMAN PSMD11 26S proteasome non-ATPase regulatory subunit 11 1.071e-06 0.30
PSD12_HUMAN PSMD12 26S proteasome non-ATPase regulatory subunit 12 1.071e-06 0.30
PSD13_HUMAN PSMD13 26S proteasome non-ATPase regulatory subunit 13 1.071e-06 0.30
PSMD1_HUMAN PSMD1 26S proteasome non-ATPase regulatory subunit 1 1.071e-06 0.30
PSMD2_HUMAN PSMD2 26S proteasome non-ATPase regulatory subunit 2 1.071e-06 0.30
PSMD3_HUMAN PSMD3 26S proteasome non-ATPase regulatory subunit 3 1.071e-06 0.30
PSMD4_HUMAN PSMD4 26S proteasome non-ATPase regulatory subunit 4 1.071e-06 0.30
PSMD6_HUMAN PSMD6 26S proteasome non-ATPase regulatory subunit 6 1.071e-06 0.30
PSMD7_HUMAN PSMD7 26S proteasome non-ATPase regulatory subunit 7 1.071e-06 0.30
PSMD8_HUMAN PSMD8 26S proteasome non-ATPase regulatory subunit 8 1.071e-06 0.30
SEM1_HUMAN SEM1 26S proteasome complex subunit SEM1 1.071e-06 0.30
PDE1B_HUMAN PDE1B Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B 1.129e-06 0.32
SAE2_HUMAN UBA2 SUMO-activating enzyme subunit 2 1.145e-06 0.31
SC6A7_HUMAN SLC6A7 Sodium-dependent proline transporter 1.166e-06 0.33
SAE1_HUMAN SAE1 SUMO-activating enzyme subunit 1 1.363e-06 0.31
PDE6A_HUMAN PDE6A Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha 1.401e-06 0.31
ARAF_HUMAN ARAF Serine/threonine-protein kinase A-Raf 1.409e-06 0.33
MMP10_HUMAN MMP10 Stromelysin-2 1.419e-06 0.29
DNM3A_HUMAN DNMT3A DNA (cytosine-5)-methyltransferase 3A 1.436e-06 0.30
CP2D6_HUMAN CYP2D6 Cytochrome P450 2D6 1.502e-06 0.36
MYLK3_HUMAN MYLK3 Myosin light chain kinase 3 1.521e-06 0.32
PARP1_HUMAN PARP1 Poly [ADP-ribose] polymerase 1 1.537e-06 0.38
Q63380_RAT NET Transporter 1.703e-06 0.33
ANKK1_HUMAN ANKK1 Ankyrin repeat and protein kinase domain-containing protein 1 1.762e-06 0.35
SENP1_HUMAN SENP1 Sentrin-specific protease 1 2.088e-06 0.29
Q72874_9HIV1 pol Pol polyprotein 2.132e-06 0.47
PCNA_HUMAN PCNA Proliferating cell nuclear antigen 2.171e-06 0.33
CHIT1_HUMAN CHIT1 Chitotriosidase-1 2.346e-06 0.30
V1BR_RAT Avpr1b Vasopressin V1b receptor 2.375e-06 0.40
FUCO_RAT Fuca1 Tissue alpha-L-fucosidase 2.488e-06 0.30
5HT1B_HUMAN HTR1B 5-hydroxytryptamine receptor 1B 2.502e-06 0.32
MMP13_BOVIN MMP13 Collagenase 3 3.129e-06 0.35
HRH2_CAVPO HRH2 Histamine H2 receptor 3.176e-06 0.35
BMR1A_HUMAN BMPR1A Bone morphogenetic protein receptor type-1A 3.384e-06 0.32
CAN1_HUMAN CAPN1 Calpain-1 catalytic subunit 3.396e-06 0.35
P2Y12_HUMAN P2RY12 P2Y purinoceptor 12 3.435e-06 0.34
M3K20_HUMAN MAP3K20 Mitogen-activated protein kinase kinase kinase 20 3.451e-06 0.35
LYN_HUMAN LYN Tyrosine-protein kinase Lyn 3.503e-06 0.36
Q8IEK1_PLAF7 M1-family alanyl aminopeptidase 3.567e-06 0.30
Q9N6S8_PLAFA Cysteine proteinase falcipain 2a 3.733e-06 0.31
LYOX_HUMAN LOX Protein-lysine 6-oxidase 4.151e-06 0.30
GRM4_HUMAN GRM4 Metabotropic glutamate receptor 4 4.298e-06 0.42
PARP2_HUMAN PARP2 Poly [ADP-ribose] polymerase 2 4.507e-06 0.33
ACACA_HUMAN ACACA Acetyl-CoA carboxylase 1 4.654e-06 0.32
NK2R_MOUSE Tacr2 Substance-K receptor 4.659e-06 0.30
PDK1_HUMAN PDK1 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial 4.946e-06 0.40
ABL1_HUMAN ABL1 Tyrosine-protein kinase ABL1 5.024e-06 0.36
MRCKA_HUMAN CDC42BPA Serine/threonine-protein kinase MRCK alpha 5.041e-06 0.35
MKNK2_HUMAN MKNK2 MAP kinase-interacting serine/threonine-protein kinase 2 5.277e-06 0.35
PPAC_HUMAN ACP1 Low molecular weight phosphotyrosine protein phosphatase 5.914e-06 0.33
DRD2_RAT Drd2 D(2) dopamine receptor 7.214e-06 0.32
KPCD2_HUMAN PRKD2 Serine/threonine-protein kinase D2 7.878e-06 0.35
RIPK2_HUMAN RIPK2 Receptor-interacting serine/threonine-protein kinase 2 7.995e-06 0.35
AA2AR_HUMAN ADORA2A Adenosine receptor A2a 8.046e-06 0.39
CHIA_HUMAN CHIA Acidic mammalian chitinase 8.365e-06 0.30
CHIA_MOUSE Chia Acidic mammalian chitinase 8.365e-06 0.30
COT2_HUMAN NR2F2 COUP transcription factor 2 8.385e-06 0.34
5HT3A_HUMAN HTR3A 5-hydroxytryptamine receptor 3A 8.419e-06 0.32
DPOL_VACCW POL DNA polymerase 8.833e-06 0.28
NR1H4_HUMAN NR1H4 Bile acid receptor 8.885e-06 0.36
MK10_RAT Mapk10 Mitogen-activated protein kinase 10 9.051e-06 0.29
PSB10_HUMAN PSMB10 Proteasome subunit beta type-10 9.221e-06 0.32
KS6B1_HUMAN RPS6KB1 Ribosomal protein S6 kinase beta-1 9.99e-06 0.43

Eltrombopag

TPOR_HUMAN MPL Thrombopoietin receptor 1.646e-17 1.00
KCNH2_HUMAN KCNH2 Potassium voltage-gated channel subfamily H member 2 0.9999 1.00
BAX_HUMAN BAX Apoptosis regulator BAX 9.365e-95 0.45
XPA_HUMAN XPA DNA repair protein complementing XP-A cells 6.921e-45 0.33
FA5_HUMAN F5 Coagulation factor V 3.584e-26 0.39
HPSE_HUMAN HPSE Heparanase 8.882e-16 0.32
GABT_RAT Abat 4-aminobutyrate aminotransferase, mitochondrial 1.221e-15 0.31
LOXL4_HUMAN LOXL4 Lysyl oxidase homolog 4 2.554e-15 0.29
R1AB_SARS rep Replicase polyprotein 1ab 2.666e-12 0.35
CYAA_BACAN cya Calmodulin-sensitive adenylate cyclase 7.15e-12 0.29
S100B_HUMAN S100B Protein S100-B 4.506e-11 0.32
O96526_LEIMA CRK3 Cdc2-related kinase 3.705e-10 0.30
U520_HUMAN SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 5.68e-10 0.30
LYAM1_HUMAN SELL L-selectin 3.331e-09 0.31
P2Y14_MOUSE P2ry14 P2Y purinoceptor 14 8.033e-08 0.29
EP300_HUMAN EP300 Histone acetyltransferase p300 1.731e-06 0.31
AAKG1_HUMAN PRKAG1 5'-AMP-activated protein kinase subunit gamma-1 2.26e-06 0.29
LYOX_HUMAN LOX Protein-lysine 6-oxidase 5.785e-06 0.29

Nylidrin

NMDE2_RAT Grin2b Glutamate receptor ionotropic, NMDA 2B 1.11e-16 1.00
NMDZ1_RAT Grin1 Glutamate receptor ionotropic, NMDA 1 7.141e-10 1.00
CP2D6_HUMAN CYP2D6 Cytochrome P450 2D6 5.397e-07 1.00
CP1A2_HUMAN CYP1A2 Cytochrome P450 1A2 0.3583 1.00
ADRB2_RAT Adrb2 Beta-2 adrenergic receptor 1.74e-96 0.59
ADRB3_RAT Adrb3 Beta-3 adrenergic receptor 1.403e-75 0.59
NEP_MOUSE Mme Neprilysin 1.36e-52 0.32
H9TVJ1_CHISP TyR1 4.288e-48 0.31
TAAR1_MACMU TAAR1 Trace amine-associated receptor 1 1.425e-45 0.33
ACER2_HUMAN ACER2 Alkaline ceramidase 2 1.353e-43 0.35
NEP_RABIT MME Neprilysin 1.813e-40 0.39
ERAP2_HUMAN ERAP2 Endoplasmic reticulum aminopeptidase 2 1.698e-36 0.36
Q8ILP4_PLAF7 Pantothenate kinase, putative 1.948e-36 0.29
AMPB_MOUSE Rnpep Aminopeptidase B 3.875e-36 0.29
AMPL_BOVIN LAP3 Cytosol aminopeptidase 3.875e-36 0.29
GLT_PYRHO Glutamate transporter homolog 3.875e-36 0.29
CANX_CHICK Calpain-1 catalytic subunit 7.62e-36 0.28
ACE_MOUSE Ace Angiotensin-converting enzyme 1.469e-33 0.32
AMPL_HUMAN LAP3 Cytosol aminopeptidase 4.028e-30 0.36
ACE_RAT Ace Angiotensin-converting enzyme 9.251e-29 0.37
AMPL_PIG LAP3 Cytosol aminopeptidase 7.813e-28 0.36
ACE_HUMAN ACE Angiotensin-converting enzyme 2.158e-27 0.39
ADRB2_HUMAN ADRB2 Beta-2 adrenergic receptor 2.186e-26 0.59
AMD_RAT Pam Peptidylglycine alpha-amidating monooxygenase 2.007e-25 0.31
Q9K2N0_PSEAI blaVIM-2 Beta-lactamase class B VIM-2 6.313e-24 0.31
AMPN_PIG ANPEP Aminopeptidase N 3.871e-23 0.36
Q3HTL5_PLAFA fp2B Falcipain 2B 4.377e-23 0.28
Q704V1_PSEAI blaGIM-1 GIM-1 protein 4.633e-23 0.28
ERAP1_HUMAN ERAP1 Endoplasmic reticulum aminopeptidase 1 1.069e-22 0.36
AMP1_PLAFQ M1 family aminopeptidase 1.005e-21 0.33
ADRB1_MOUSE Adrb1 Beta-1 adrenergic receptor 3.951e-21 0.30
ADRB3_HUMAN ADRB3 Beta-3 adrenergic receptor 4.461e-20 0.44
OPRM_RAT Oprm1 Mu-type opioid receptor 7.507e-20 0.34
GLUT4_HUMAN SLC2A4 Solute carrier family 2, facilitated glucose transporter member 4 5.41e-19 0.30
MMP3_HUMAN MMP3 Stromelysin-1 1.517e-18 0.37
AMPN_HUMAN ANPEP Aminopeptidase N 1.853e-18 0.37
LCAP_RAT Lnpep Leucyl-cystinyl aminopeptidase 4.879e-18 0.29
LCAP_HUMAN LNPEP Leucyl-cystinyl aminopeptidase 5.099e-17 0.35
ADRB1_HUMAN ADRB1 Beta-1 adrenergic receptor 1.11e-16 0.45
ADRB2_BOVIN ADRB2 Beta-2 adrenergic receptor 1.11e-16 0.40
DNPEP_HUMAN DNPEP Aspartyl aminopeptidase 1.11e-16 0.32
GLI1_HUMAN GLI1 Zinc finger protein GLI1 1.11e-16 0.32
SGMR1_HUMAN SIGMAR1 Sigma non-opioid intracellular receptor 1 3.331e-16 0.48
ADRB3_CANLF ADRB3 Beta-3 adrenergic receptor 5.551e-16 0.35
SC6A5_HUMAN SLC6A5 Sodium- and chloride-dependent glycine transporter 2 5.551e-16 0.33
S15A1_HUMAN SLC15A1 Solute carrier family 15 member 1 1.665e-15 0.29
EAA4_RAT Slc1a6 Excitatory amino acid transporter 4 4.441e-15 0.29
PPAP_HUMAN ACP3 Prostatic acid phosphatase 1.166e-14 0.29
ACE2_RAT Ace2 Angiotensin-converting enzyme 2 5.007e-14 0.31
CBPA1_BOVIN CPA1 Carboxypeptidase A1 7.594e-14 0.33
VMAT2_MOUSE Slc18a2 Synaptic vesicular amine transporter 1.463e-13 0.33
AMPB_RAT Rnpep Aminopeptidase B 1.973e-13 0.29
ADRB2_MESAU ADRB2 Beta-2 adrenergic receptor 3.922e-13 0.29
NEP_HUMAN MME Neprilysin 1.681e-12 0.34
OPRD_RAT Oprd1 Delta-type opioid receptor 4.295e-12 0.34
ADRB2_CANLF ADRB2 Beta-2 adrenergic receptor 5.615e-12 0.40
AOC3_HUMAN AOC3 Membrane primary amine oxidase 6.092e-12 0.35
OPRK_RAT Oprk1 Kappa-type opioid receptor 6.202e-12 0.34
AMPX_VIBPR Bacterial leucyl aminopeptidase 9.7e-12 0.29
CALM_BOVIN CALM Calmodulin 1.462e-11 0.31
ADRB2_CAVPO Adrb2 Beta-2 adrenergic receptor 2.401e-11 0.56
NEP_RAT Mme Neprilysin 3.699e-11 0.33
SYYC_HUMAN YARS1 Tyrosine--tRNA ligase, cytoplasmic 4.28e-11 0.31
NMUR2_HUMAN NMUR2 Neuromedin-U receptor 2 5.054e-11 0.35
SCYD_MAGO7 SDH1 Scytalone dehydratase 7.941e-11 0.42
Q72874_9HIV1 pol Pol polyprotein 8.506e-11 0.39
AMPN_MOUSE Anpep Aminopeptidase N 1.105e-10 0.29
SOAT1_CHLAE SOAT1 Sterol O-acyltransferase 1 1.25e-10 0.31
CAN1_PIG CAPN1 Calpain-1 catalytic subunit 1.337e-10 0.30
NEP_PIG MME Neprilysin 1.66e-10 0.31
CAN1_HUMAN CAPN1 Calpain-1 catalytic subunit 2.447e-10 0.31
MMP1_HUMAN MMP1 Interstitial collagenase 3.439e-10 0.37
ESR1_HUMAN ESR1 Estrogen receptor 4.743e-10 0.40
ESR2_HUMAN ESR2 Estrogen receptor beta 6.362e-10 0.40
B0FL73_CAVPO ADRB1 Beta-1 adrenergic receptor 8.145e-10 0.45
ACE_RABIT ACE Angiotensin-converting enzyme 1.465e-09 0.31
PPO1_AGABI PPO1 Polyphenol oxidase 1 1.582e-09 0.30
PEPA_PIG PGA Pepsin A 2.939e-09 0.38
MMP8_HUMAN MMP8 Neutrophil collagenase 3.225e-09 0.36
CTRB1_HUMAN CTRB1 Chymotrypsinogen B 4.5e-09 0.32
ANF_HUMAN NPPA Natriuretic peptides A 4.63e-09 0.32
THER_BACTH npr Thermolysin 5.224e-09 0.29
ELAS_PSEAE lasB Elastase 5.559e-09 0.29
VMAT2_HUMAN SLC18A2 Synaptic vesicular amine transporter 7.167e-09 0.33
MMP2_HUMAN MMP2 72 kDa type IV collagenase 8.205e-09 0.34
VMAT2_RAT Slc18a2 Synaptic vesicular amine transporter 1.13e-08 0.34
DLG4_HUMAN DLG4 Disks large homolog 4 1.256e-08 0.32
Q63380_RAT NET Transporter 1.713e-08 0.34
GPR88_HUMAN GPR88 Probable G-protein coupled receptor 88 1.894e-08 0.32
NMDE2_HUMAN GRIN2B Glutamate receptor ionotropic, NMDA 2B 2.218e-08 0.48
SGMR1_RAT Sigmar1 Sigma non-opioid intracellular receptor 1 2.446e-08 0.48
SOAT2_CHLAE SOAT2 Sterol O-acyltransferase 2 2.596e-08 0.31
ERR3_MOUSE Esrrg Estrogen-related receptor gamma 2.929e-08 0.29
TAAR1_HUMAN TAAR1 Trace amine-associated receptor 1 3.782e-08 0.37
TS1R1_HUMAN TAS1R1 Taste receptor type 1 member 1 2.137e-07 0.36
ACPS_BACSU acpS Holo-[acyl-carrier-protein] synthase 2.601e-07 0.30
GRIA1_HUMAN GRIA1 Glutamate receptor 1 2.978e-07 0.33
LOX15_RABIT ALOX15 Arachidonate 15-lipoxygenase 4.147e-07 0.44
CAN2_HUMAN CAPN2 Calpain-2 catalytic subunit 4.225e-07 0.31
OPRM_CAVPO OPRM1 Mu-type opioid receptor 4.368e-07 0.31
PSA_HUMAN NPEPPS Puromycin-sensitive aminopeptidase 4.905e-07 0.29
CBPA1_HUMAN CPA1 Carboxypeptidase A1 4.924e-07 0.29
ADRB1_RAT Adrb1 Beta-1 adrenergic receptor 5.885e-07 0.34
SC6A3_MACFA SLC6A3 Sodium-dependent dopamine transporter 6.013e-07 0.28
NK1R_RAT Tacr1 Substance-P receptor 9.324e-07 0.32
SC6A3_RAT Slc6a3 Sodium-dependent dopamine transporter 9.417e-07 0.48
MAP2_HUMAN METAP2 Methionine aminopeptidase 2 9.696e-07 0.37
LPXC_ECOLI lpxC UDP-3-O-acyl-N-acetylglucosamine deacetylase 1.481e-06 0.30
S22A1_HUMAN SLC22A1 Solute carrier family 22 member 1 1.565e-06 0.44
CEL2A_PIG CELA2A Chymotrypsin-like elastase family member 2A 1.689e-06 0.30
ERG2_YEAST ERG2 C-8 sterol isomerase 1.808e-06 0.48
TRPA1_RAT Trpa1 Transient receptor potential cation channel subfamily A member 1 2.056e-06 0.30
TYRO_HUMAN TYR Tyrosinase 2.078e-06 0.30
CPNS1_HUMAN CAPNS1 Calpain small subunit 1 2.849e-06 0.29
MMP12_HUMAN MMP12 Macrophage metalloelastase 3.577e-06 0.31
MDR1_HUMAN ABCB1 ATP-dependent translocase ABCB1 3.875e-06 0.33
Q9N6S8_PLAFA Cysteine proteinase falcipain 2a 5.613e-06 0.30
Q8CGM4_CAVPO OPRM1 Mu-opioid receptor 5.619e-06 0.30
SCN2A_RAT Scn2a Sodium channel protein type 2 subunit alpha 7.093e-06 0.30
PSB1_HUMAN PSMB1 Proteasome subunit beta type-1 7.347e-06 0.32
PSA1_HUMAN PSMA1 Proteasome subunit alpha type-1 7.891e-06 0.32
PSA2_HUMAN PSMA2 Proteasome subunit alpha type-2 7.891e-06 0.32
PSA3_HUMAN PSMA3 Proteasome subunit alpha type-3 7.891e-06 0.32
PSA4_HUMAN PSMA4 Proteasome subunit alpha type-4 7.891e-06 0.32
PSA5_HUMAN PSMA5 Proteasome subunit alpha type-5 7.891e-06 0.32
PSA6_HUMAN PSMA6 Proteasome subunit alpha type-6 7.891e-06 0.32
PSA7_HUMAN PSMA7 Proteasome subunit alpha type-7 7.891e-06 0.32
PSB11_HUMAN PSMB11 Proteasome subunit beta type-11 7.891e-06 0.32
PSB3_HUMAN PSMB3 Proteasome subunit beta type-3 7.891e-06 0.32
PSB4_HUMAN PSMB4 Proteasome subunit beta type-4 7.891e-06 0.32
PSB6_HUMAN PSMB6 Proteasome subunit beta type-6 7.891e-06 0.32
PSB7_HUMAN PSMB7 Proteasome subunit beta type-7 7.891e-06 0.32
PSMA8_HUMAN PSMA8 Proteasome subunit alpha-type 8 7.891e-06 0.32
PERM_HUMAN MPO Myeloperoxidase 7.969e-06 0.36
OPRD_HUMAN OPRD1 Delta-type opioid receptor 8.387e-06 0.35

Noscapine

S22A2_HUMAN SLC22A2 Solute carrier family 22 member 2 3.331e-16 1.00
CP2D6_HUMAN CYP2D6 Cytochrome P450 2D6 0.001271 1.00
CP3A4_HUMAN CYP3A4 Cytochrome P450 3A4 0.02325 1.00
CP2CJ_HUMAN CYP2C19 Cytochrome P450 2C19 0.03687 1.00
CP2C9_HUMAN CYP2C9 Cytochrome P450 2C9 0.07382 1.00
VE2_HPV1 E2 Regulatory protein E2 2.419e-39 0.31
HCN2_MOUSE Hcn2 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 3.129e-35 0.29
DRD1_RAT Drd1 D(1A) dopamine receptor 2.341e-29 0.50
TBB5_HUMAN TUBB Tubulin beta chain 2.063e-23 0.29
TPPP_BOVIN TPPP Tubulin polymerization-promoting protein 2.063e-23 0.29
DYR_STAAW folA Dihydrofolate reductase 4.05e-20 0.30
ACHA2_HUMAN CHRNA2 Neuronal acetylcholine receptor subunit alpha-2 7.563e-20 0.32
GBRG1_RAT Gabrg1 Gamma-aminobutyric acid receptor subunit gamma-1 4.073e-19 0.58
TF_HUMAN F3 Tissue factor 2.554e-15 0.39
DRD1_HUMAN DRD1 D(1A) dopamine receptor 4.996e-15 0.49
DRD5_HUMAN DRD5 D(1B) dopamine receptor 9.37e-14 0.49
HCN1_MOUSE Hcn1 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 4.673e-13 0.28
DRD2_RAT Drd2 D(2) dopamine receptor 1.237e-11 0.43
MDR1B_MOUSE Abcb1b ATP-dependent translocase ABCB1 2.365e-11 0.34
KCNN1_HUMAN KCNN1 Small conductance calcium-activated potassium channel protein 1 1.441e-10 0.33
HCN4_HUMAN HCN4 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 4.57e-10 0.29
NANA_STREE nanA Sialidase A 5.076e-10 0.29
KCNN2_HUMAN KCNN2 Small conductance calcium-activated potassium channel protein 2 7.167e-09 0.33
NR0B1_HUMAN NR0B1 Nuclear receptor subfamily 0 group B member 1 8.548e-09 0.31
EDNRA_HUMAN EDNRA Endothelin-1 receptor 3.188e-08 0.33
DCOR_HUMAN ODC1 Ornithine decarboxylase 3.632e-08 0.30
TBB2B_BOVIN TUBB2B Tubulin beta-2B chain 3.792e-08 0.42
5HT7R_HUMAN HTR7 5-hydroxytryptamine receptor 7 7.898e-08 0.49
EDNRB_MOUSE Ednrb Endothelin receptor type B 1.227e-07 0.28
MTR1B_HUMAN MTNR1B Melatonin receptor type 1B 1.441e-07 0.31
PLAP_HUMAN PLAA Phospholipase A-2-activating protein 1.881e-07 0.35
OPRK_RAT Oprk1 Kappa-type opioid receptor 5.601e-07 0.34
EDNRB_HUMAN EDNRB Endothelin receptor type B 8.443e-07 0.33
5HT2B_HUMAN HTR2B 5-hydroxytryptamine receptor 2B 1.294e-06 0.49
KCNN3_HUMAN KCNN3 Small conductance calcium-activated potassium channel protein 3 2.417e-06 0.33
S22A3_HUMAN SLC22A3 Solute carrier family 22 member 3 2.631e-06 0.29
5HT1A_HUMAN HTR1A 5-hydroxytryptamine receptor 1A 3.132e-06 0.39
FKB1A_HUMAN FKBP1A Peptidyl-prolyl cis-trans isomerase FKBP1A 3.278e-06 0.31
RAD52_HUMAN RAD52 DNA repair protein RAD52 homolog 3.39e-06 0.49
PDE1A_HUMAN PDE1A Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4.194e-06 0.32

Mianserin

5HT2A_HUMAN HTR2A 5-hydroxytryptamine receptor 2A 5.551e-15 1.00
HRH2_CAVPO HRH2 Histamine H2 receptor 7.375e-07 1.00
CP2D6_HUMAN CYP2D6 Cytochrome P450 2D6 0.0001059 1.00
SC6A2_MOUSE Slc6a2 Sodium-dependent noradrenaline transporter 2.137e-35 0.31
DRD5_HUMAN DRD5 D(1B) dopamine receptor 1.381e-34 0.41
SC6A3_MOUSE Slc6a3 Sodium-dependent dopamine transporter 2.563e-25 0.31
HRH1_HUMAN HRH1 Histamine H1 receptor 9.465e-24 0.64
DRD1_HUMAN DRD1 D(1A) dopamine receptor 5.527e-21 0.41
ADA1B_MESAU ADRA1B Alpha-1B adrenergic receptor 2.334e-20 0.37
DRD1_RAT Drd1 D(1A) dopamine receptor 8.076e-19 0.64
5HT2C_MOUSE Htr2c 5-hydroxytryptamine receptor 2C 4.157e-18 0.35
ADA1A_BOVIN ADRA1A Alpha-1A adrenergic receptor 4.307e-18 0.37
KAT3_HUMAN KYAT3 Kynurenine--oxoglutarate transaminase 3 7.502e-18 0.28
Q9IP65_HCMV US28 G protein-coupled receptor 3.331e-16 0.31
AADAT_RAT Aadat Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial 2.554e-15 0.28
5HT2A_PIG HTR2A 5-hydroxytryptamine receptor 2A 5.551e-15 0.41
5HT2C_HUMAN HTR2C 5-hydroxytryptamine receptor 2C 9.489e-13 0.64
HRH1_RAT Hrh1 Histamine H1 receptor 6.596e-12 0.38
5HT2A_RAT Htr2a 5-hydroxytryptamine receptor 2A 6.648e-12 0.66
5HT2C_RAT Htr2c 5-hydroxytryptamine receptor 2C 1.028e-11 0.66
DRD4_HUMAN DRD4 D(4) dopamine receptor 1.112e-11 0.61
US28_HCMVA US28 G-protein coupled receptor homolog US28 1.717e-11 0.31
Q9WTR4_RAT Slc6a2 Transporter 2.341e-11 0.64
DRD2_HUMAN DRD2 D(2) dopamine receptor 3.569e-11 0.54
DRD5_RAT Drd5 D(1B) dopamine receptor 5.388e-10 0.29
SC6A2_HUMAN SLC6A2 Sodium-dependent noradrenaline transporter 9.083e-10 0.38
ADA1D_RAT Adra1d Alpha-1D adrenergic receptor 2.31e-09 0.37
ADA2A_HUMAN ADRA2A Alpha-2A adrenergic receptor 3.035e-09 0.64
SC6A3_HUMAN SLC6A3 Sodium-dependent dopamine transporter 3.14e-09 0.38
SETD7_HUMAN SETD7 Histone-lysine N-methyltransferase SETD7 4.438e-09 0.28
ACM5_RAT Chrm5 Muscarinic acetylcholine receptor M5 5.587e-09 0.43
DRD3_RAT Drd3 D(3) dopamine receptor 6.602e-09 0.38
DRD2_RAT Drd2 D(2) dopamine receptor 1.569e-08 0.64
DRD3_HUMAN DRD3 D(3) dopamine receptor 1.679e-08 0.64
ADA2C_HUMAN ADRA2C Alpha-2C adrenergic receptor 1.792e-08 0.64
5HT7R_RAT Htr7 5-hydroxytryptamine receptor 7 2.802e-08 0.35
S22A2_HUMAN SLC22A2 Solute carrier family 22 member 2 1.406e-07 0.44
S47A1_HUMAN SLC47A1 Multidrug and toxin extrusion protein 1 3.203e-07 0.44
SC6A4_HUMAN SLC6A4 Sodium-dependent serotonin transporter 4.388e-07 0.38
ADA2B_HUMAN ADRA2B Alpha-2B adrenergic receptor 1.472e-06 0.64
PDR5_YEAST PDR5 Pleiotropic ABC efflux transporter of multiple drugs 1.683e-06 0.29
ACHP_LYMST Acetylcholine-binding protein 1.928e-06 0.35
5HT1E_HUMAN HTR1E 5-hydroxytryptamine receptor 1E 2.425e-06 0.36

Asenapine

5HT2C_HUMAN HTR2C 5-hydroxytryptamine receptor 2C 4.598e-12 1.00
5HT2A_HUMAN HTR2A 5-hydroxytryptamine receptor 2A 3.691e-08 1.00
DRD1_HUMAN DRD1 D(1A) dopamine receptor 3.042e-06 1.00
HRH2_HUMAN HRH2 Histamine H2 receptor 1.972e-05 1.00
DRD2_HUMAN DRD2 D(2) dopamine receptor 3.133e-05 1.00
DRD4_HUMAN DRD4 D(4) dopamine receptor 3.44e-05 1.00
DRD3_HUMAN DRD3 D(3) dopamine receptor 0.000217 1.00
5HT6R_HUMAN HTR6 5-hydroxytryptamine receptor 6 0.1898 1.00
OPRX_RAT Oprl1 Nociceptin receptor 8.43e-65 0.53
TYTR_TRYBB TPR Trypanothione reductase 9.088e-39 0.36
NCLX_HUMAN SLC8B1 Mitochondrial sodium/calcium exchanger protein 3.875e-36 0.29
5HT2C_CANLF HTR2C 5-hydroxytryptamine receptor 2C 9.719e-24 0.29
Q9WTR4_RAT Slc6a2 Transporter 8.882e-16 0.53
FFAR4_RAT Ffar4 Free fatty acid receptor 4 3.22e-15 0.29
DRD1_RAT Drd1 D(1A) dopamine receptor 6.994e-15 0.36
SC6A2_MOUSE Slc6a2 Sodium-dependent noradrenaline transporter 2.58e-12 0.32
AHR_HUMAN AHR Aryl hydrocarbon receptor 1.055e-11 0.38
SC6A3_RAT Slc6a3 Sodium-dependent dopamine transporter 1.031e-10 0.43
5HT5A_RAT Htr5a 5-hydroxytryptamine receptor 5A 1.213e-10 0.29
Q8WMX0_BOVIN Muscarinic receptor M1 1.246e-09 0.33
GLRA3_HUMAN GLRA3 Glycine receptor subunit alpha-3 2.603e-09 0.31
HRH4_HUMAN HRH4 Histamine H4 receptor 5.487e-09 0.46
HRH1_RAT Hrh1 Histamine H1 receptor 5.769e-09 0.45
SMCA2_HUMAN SMARCA2 Probable global transcription activator SNF2L2 1.111e-08 0.29
ACM5_RAT Chrm5 Muscarinic acetylcholine receptor M5 1.422e-07 0.35
HRH1_HUMAN HRH1 Histamine H1 receptor 4.59e-07 0.53
SC6A3_MOUSE Slc6a3 Sodium-dependent dopamine transporter 6.318e-07 0.32
5HT2C_RAT Htr2c 5-hydroxytryptamine receptor 2C 9.815e-07 0.46
5HT2B_HUMAN HTR2B 5-hydroxytryptamine receptor 2B 1.233e-06 0.37
5HT2A_RAT Htr2a 5-hydroxytryptamine receptor 2A 1.326e-06 0.46
ADA2C_HUMAN ADRA2C Alpha-2C adrenergic receptor 3.058e-06 0.53
SC6A4_RAT Slc6a4 Sodium-dependent serotonin transporter 4.376e-06 0.40
NOS3_HUMAN NOS3 Nitric oxide synthase, endothelial 7.145e-06 0.31
DRD2_RAT Drd2 D(2) dopamine receptor 7.427e-06 0.45

Vernakalant

KCNA5_HUMAN KCNA5 Potassium voltage-gated channel subfamily A member 5 1.283e-09 1.00
KCNH2_HUMAN KCNH2 Potassium voltage-gated channel subfamily H member 2 0.2232 1.00
FKBP4_HUMAN FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4 5.735e-86 0.35
KCNB1_RAT Kcnb1 Potassium voltage-gated channel subfamily B member 1 2.297e-76 0.47
FKBP5_HUMAN FKBP5 Peptidyl-prolyl cis-trans isomerase FKBP5 9.489e-73 0.35
FKB1A_HUMAN FKBP1A Peptidyl-prolyl cis-trans isomerase FKBP1A 1.475e-61 0.39
KCND2_RAT Kcnd2 Potassium voltage-gated channel subfamily D member 2 3.705e-42 0.34
Q9XSD0_PIG NHE3 Sodium/hydrogen exchanger isoform 3 1.713e-41 0.33
PDE4B_HUMAN PDE4B cAMP-specific 3',5'-cyclic phosphodiesterase 4B 2.153e-37 0.40
LOLA_ECOLI lolA Outer-membrane lipoprotein carrier protein 7.142e-37 0.29
NU1M_BOVIN MT-ND1 NADH-ubiquinone oxidoreductase chain 1 1.131e-27 0.31
HCN1_MOUSE Hcn1 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 1.316e-27 0.31
SC6A4_MOUSE Slc6a4 Sodium-dependent serotonin transporter 1.85e-27 0.36
VMAT2_RAT Slc18a2 Synaptic vesicular amine transporter 1.802e-23 0.39
SC6A3_MOUSE Slc6a3 Sodium-dependent dopamine transporter 7.232e-23 0.34
PDE4A_HUMAN PDE4A cAMP-specific 3',5'-cyclic phosphodiesterase 4A 5.787e-22 0.34
EBPL_HUMAN EBPL Emopamil-binding protein-like 3.27e-21 0.34
HCN2_MOUSE Hcn2 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 2.444e-20 0.32
Q8WQX9_9TRYP PDEB1 Phosphodiesterase 1.114e-19 0.32
PDE4D_HUMAN PDE4D cAMP-specific 3',5'-cyclic phosphodiesterase 4D 5.429e-18 0.34
HCN4_HUMAN HCN4 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 3.331e-16 0.32
BRAF_MOUSE Braf Serine/threonine-protein kinase B-raf 6.661e-16 0.32
VMAT2_HUMAN SLC18A2 Synaptic vesicular amine transporter 3.22e-15 0.31
SL9A5_HUMAN SLC9A5 Sodium/hydrogen exchanger 5 5.329e-15 0.33
Q9JKC1_RAT Bche Carboxylic ester hydrolase 7.516e-14 0.35
LYPA2_HUMAN LYPLA2 Acyl-protein thioesterase 2 8.444e-13 0.31
DHCR7_HUMAN DHCR7 7-dehydrocholesterol reductase 1.116e-12 0.38
VMAT2_MOUSE Slc18a2 Synaptic vesicular amine transporter 1.267e-12 0.31
CXL10_HUMAN CXCL10 C-X-C motif chemokine 10 1.402e-12 0.30
VACHT_HUMAN SLC18A3 Vesicular acetylcholine transporter 5.441e-12 0.31
ASM_HUMAN SMPD1 Sphingomyelin phosphodiesterase 9.7e-12 0.29
LYPA1_HUMAN LYPLA1 Acyl-protein thioesterase 1 1.215e-11 0.31
OX1R_HUMAN HCRTR1 Orexin receptor type 1 1.999e-11 0.36
DRD1_PIG DRD1 D(1A) dopamine receptor 3.47e-11 0.34
OX2R_HUMAN HCRTR2 Orexin receptor type 2 3.64e-11 0.36
KCNN1_HUMAN KCNN1 Small conductance calcium-activated potassium channel protein 1 1.91e-09 0.30
SL9A3_HUMAN SLC9A3 Sodium/hydrogen exchanger 3 3.403e-09 0.34
SSR5_HUMAN SSTR5 Somatostatin receptor type 5 7.208e-09 0.35
SGMR1_RAT Sigmar1 Sigma non-opioid intracellular receptor 1 1.146e-08 0.36
ADA1D_RAT Adra1d Alpha-1D adrenergic receptor 2.88e-08 0.30
Q49PX0_9POXV N1L N1L 5.363e-08 0.28
KCNN2_HUMAN KCNN2 Small conductance calcium-activated potassium channel protein 2 6.101e-08 0.30
ACM5_RAT Chrm5 Muscarinic acetylcholine receptor M5 1.475e-07 0.35
EBP_HUMAN EBP 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase 1.71e-07 0.36
ADRB1_MOUSE Adrb1 Beta-1 adrenergic receptor 1.895e-07 0.29
Q8QGU2_CHICK FKBP12.6 Peptidylprolyl isomerase 2.869e-07 0.28
SGMR1_HUMAN SIGMAR1 Sigma non-opioid intracellular receptor 1 2.896e-07 0.42
CCR4_MOUSE Ccr4 C-C chemokine receptor type 4 3.917e-07 0.30
MIP_LEGPN mip Outer membrane protein MIP 6.033e-07 0.29
OPRK_CAVPO OPRK1 Kappa-type opioid receptor 6.384e-07 0.39
5HT2B_HUMAN HTR2B 5-hydroxytryptamine receptor 2B 7.855e-07 0.31
Q5TKS5_STAAU fabI Enoyl-ACP reductase 2.053e-06 0.29
OPRK_HUMAN OPRK1 Kappa-type opioid receptor 3.027e-06 0.39
SGMR1_CAVPO SIGMAR1 Sigma non-opioid intracellular receptor 1 5.2e-06 0.37
NK1R_MERUN TACR1 Substance-P receptor 6.904e-06 0.29
ADA1D_HUMAN ADRA1D Alpha-1D adrenergic receptor 7.013e-06 0.33
MRGX1_RAT Mrgprx1 Mas-related G-protein coupled receptor member X1 7.094e-06 0.30
5HT4R_RAT Htr4 5-hydroxytryptamine receptor 4 8.965e-06 0.34

Sulfadimethoxine

5HT6R_HUMAN HTR6 5-hydroxytryptamine receptor 6 3.919e-07 1.00
S22AC_HUMAN SLC22A12 Solute carrier family 22 member 12 6.884e-61 0.34
BRD4_MOUSE Brd4 Bromodomain-containing protein 4 8.747e-51 0.32
BPTF_HUMAN BPTF Nucleosome-remodeling factor subunit BPTF 1.127e-48 0.32
Q56D22_MACMU HSD11B1 Hydroxysteroid 11-beta dehydrogenase 1 9.523e-43 0.34
Q81VW8_BACAN folP Dihydropteroate synthase 7.947e-40 0.53
LN28A_MOUSE Lin28a Protein lin-28 homolog A 1.775e-36 0.29
ILVB_YEAST ILV2 Acetolactate synthase catalytic subunit, mitochondrial 1.664e-34 0.30
ILVB_ARATH ALS Acetolactate synthase, chloroplastic 8.992e-33 0.30
SCN9A_HUMAN SCN9A Sodium channel protein type 9 subunit alpha 1.621e-30 0.35
SMCA4_HUMAN SMARCA4 Transcription activator BRG1 1.106e-27 0.32
SC5A7_RAT Slc5a7 High affinity choline transporter 1 1.79e-27 0.34
Q5TU56_ANOGA 1272966 Carbonic anhydrase 1.077e-24 0.40
BRPF3_HUMAN BRPF3 Bromodomain and PHD finger-containing protein 3 1.047e-23 0.30
CYNT_HELPY cynT Carbonic anhydrase 1.068e-23 0.37
5HT6R_MOUSE Htr6 5-hydroxytryptamine receptor 6 2.847e-23 0.29
TIF1A_HUMAN TRIM24 Transcription intermediary factor 1-alpha 1.146e-21 0.36
Q5XX84_CANLF HSD11B1 11-beta-hydroxysteroid dehydrogenase type 1 2.917e-21 0.34
FFAR4_RAT Ffar4 Free fatty acid receptor 4 1.441e-20 0.40
BRD1_HUMAN BRD1 Bromodomain-containing protein 1 5.789e-20 0.33
BRD7_HUMAN BRD7 Bromodomain-containing protein 7 1.679e-19 0.32
Q5U9J1_THAWE ca1 Delta carbonic anhydrase 6.649e-18 0.40
C0IX24_STYPI CA2 Carbonic anhydrase 1.494e-17 0.37
B2V8E3_SULSY Carbonate dehydratase 1.11e-16 0.37
B5SU02_STYPI CA Alpha carbonic anhydrase 1.11e-16 0.37
Q31FD6_HYDCU Carbonic anhydrase, alpha family 1.11e-16 0.37
CCR9_HUMAN CCR9 C-C chemokine receptor type 9 2.22e-16 0.32
A6YCJ1_9METZ Astrosclerin-3 5.551e-16 0.37
KMO_RAT Kmo Kynurenine 3-monooxygenase 7.772e-16 0.34
MTCA2_MYCTU mtcA2 Carbonic anhydrase 2 8.882e-16 0.37
FFAR4_HUMAN FFAR4 Free fatty acid receptor 4 1.11e-15 0.40
BRPF1_HUMAN BRPF1 Peregrin 4.441e-15 0.33
CAN_YEAST NCE103 Carbonic anhydrase 4.752e-14 0.37
PFKA_TRYCC pfk ATP-dependent 6-phosphofructokinase 1.912e-13 0.30
CAH13_MOUSE Ca13 Carbonic anhydrase 13 2.062e-13 0.40
KEAP1_HUMAN KEAP1 Kelch-like ECH-associated protein 1 3.755e-13 0.37
PFKA_TRYBB pfk ATP-dependent 6-phosphofructokinase 1.479e-12 0.30
CP51_MYCTU cyp51 Lanosterol 14-alpha demethylase 2.867e-12 0.39
CAH_METTE Carbonic anhydrase 3.351e-12 0.32
PPBI_BOVIN ALPI Intestinal-type alkaline phosphatase 3.62e-12 0.47
BAZ2B_HUMAN BAZ2B Bromodomain adjacent to zinc finger domain protein 2B 4.774e-12 0.32
POLG_DEN2P Genome polyprotein 1.351e-11 0.52
J7HAW4_RAPRA Acetolactate synthase 1.92e-11 0.31
Q3I4V7_CRYNV CAN2 Carbonic anhydrase 3.246e-11 0.37
PPBT_BOVIN ALPL Alkaline phosphatase, tissue-nonspecific isozyme 4.275e-11 0.30
CAH2_BOVIN CA2 Carbonic anhydrase 2 4.734e-11 0.32
CAH15_MOUSE Ca15 Carbonic anhydrase 15 8.798e-10 0.32
Q6FTL6_CANGA NCE103 Carbonic anhydrase 9.198e-10 0.37
MEP1B_HUMAN MEP1B Meprin A subunit beta 1.023e-08 0.30
MTCA1_MYCTU mtcA1 Beta-carbonic anhydrase 1 1.028e-08 0.37
IKBA_HUMAN NFKBIA NF-kappa-B inhibitor alpha 1.274e-08 0.30
Q548M1_ECOLX groL 60 kDa chaperonin 9.405e-08 0.37
Q7BGE6_ECOLX groES 10 kDa chaperonin 9.405e-08 0.37
METC_ECOLI metC Cystathionine beta-lyase MetC 1.995e-07 0.29
P3C2G_HUMAN PIK3C2G Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma 2.65e-07 0.34
PPIA_HUMAN PPIA Peptidyl-prolyl cis-trans isomerase A 2.798e-07 0.30
P96878_MYCTU Probable transmembrane carbonic anhydrase (Carbonate dehydratase) (Carbonic dehydratase) 3.664e-07 0.32
5NTD_HUMAN NT5E 5'-nucleotidase 4.192e-07 0.34
KAT2B_HUMAN KAT2B Histone acetyltransferase KAT2B 4.198e-07 0.32
CAN_CANAL NCE103 Carbonic anhydrase 4.496e-07 0.37
LOX12_HUMAN ALOX12 Arachidonate 12-lipoxygenase, 12S-type 5.132e-07 0.31
BRD4_HUMAN BRD4 Bromodomain-containing protein 4 1.063e-06 0.35
AKT1_MOUSE Akt1 RAC-alpha serine/threonine-protein kinase 1.142e-06 0.28
CAH6_HUMAN CA6 Carbonic anhydrase 6 1.215e-06 0.37
CAH4_BOVIN CA4 Carbonic anhydrase 4 1.582e-06 0.40
CAH2_HUMAN CA2 Carbonic anhydrase 2 1.908e-06 0.40
CAH9_HUMAN CA9 Carbonic anhydrase 9 2.18e-06 0.40
Q388H8_TRYB2 Glycylpeptide N-tetradecanoyltransferase 2.652e-06 0.37
OGT1_HUMAN OGT UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 3.073e-06 0.30
EAA1_HUMAN SLC1A3 Excitatory amino acid transporter 1 3.418e-06 0.34
CAH1_HUMAN CA1 Carbonic anhydrase 1 3.878e-06 0.40
CCR4_HUMAN CCR4 C-C chemokine receptor type 4 3.924e-06 0.36
S40A1_HUMAN SLC40A1 Solute carrier family 40 member 1 5.439e-06 0.33

Pizotifen

DRD2_HUMAN DRD2 D(2) dopamine receptor 4.129e-06 1.00
5HT2B_HUMAN HTR2B 5-hydroxytryptamine receptor 2B 0.0003936 1.00
ACM1_HUMAN CHRM1 Muscarinic acetylcholine receptor M1 0.002931 1.00
CP2D6_HUMAN CYP2D6 Cytochrome P450 2D6 0.006149 1.00
5HT2C_HUMAN HTR2C 5-hydroxytryptamine receptor 2C 0.01161 1.00
5HT7R_HUMAN HTR7 5-hydroxytryptamine receptor 7 0.03704 1.00
5HT2A_HUMAN HTR2A 5-hydroxytryptamine receptor 2A 0.05093 1.00
SETD7_HUMAN SETD7 Histone-lysine N-methyltransferase SETD7 5.502e-44 0.56
DRD5_HUMAN DRD5 D(1B) dopamine receptor 7.754e-37 0.49
HRH1_RAT Hrh1 Histamine H1 receptor 1.985e-36 0.56
ADA2A_BOVIN ADRA2A Alpha-2A adrenergic receptor 5.672e-22 0.52
5HT2A_PIG HTR2A 5-hydroxytryptamine receptor 2A 1.11e-16 0.39
ADA1A_BOVIN ADRA1A Alpha-1A adrenergic receptor 1.11e-16 0.52
5HT2C_MOUSE Htr2c 5-hydroxytryptamine receptor 2C 1.554e-15 0.54
5HT3B_HUMAN HTR3B 5-hydroxytryptamine receptor 3B 2.22e-15 0.29
DRD1_HUMAN DRD1 D(1A) dopamine receptor 7.661e-15 0.64
5HT2A_RAT Htr2a 5-hydroxytryptamine receptor 2A 7.438e-11 0.76
PTAFR_HUMAN PTAFR Platelet-activating factor receptor 1.006e-10 0.41
DRD1_RAT Drd1 D(1A) dopamine receptor 2.125e-10 0.31
SC6A4_MOUSE Slc6a4 Sodium-dependent serotonin transporter 8.386e-10 0.54
HRH2_HUMAN HRH2 Histamine H2 receptor 9.959e-09 0.64
DRD4_HUMAN DRD4 D(4) dopamine receptor 4.29e-08 0.49
HRH4_HUMAN HRH4 Histamine H4 receptor 6.102e-08 0.45
HRH4_RAT Hrh4 Histamine H4 receptor 9.017e-08 0.35
SC6A2_MOUSE Slc6a2 Sodium-dependent noradrenaline transporter 1.004e-07 0.54
HRH1_HUMAN HRH1 Histamine H1 receptor 1.448e-07 0.64
ADA2B_HUMAN ADRA2B Alpha-2B adrenergic receptor 4.065e-07 0.64
5HT2C_RAT Htr2c 5-hydroxytryptamine receptor 2C 5.805e-07 0.34
ACHP_LYMST Acetylcholine-binding protein 3.181e-06 0.34

Doripenem

CAC1C_HUMAN CACNA1C Voltage-dependent L-type calcium channel subunit alpha-1C 5.715e-06 1.00
D1MIX9_PSEAI blaGES-13 Beta-lactamase 2.208e-20 0.32
A2RP81_CITFR blaPER-2 Beta-lactamase 8.216e-15 0.32
BLAT_ECOLX bla; blaT-3; blaT-4; blaT-5; blaT-6 Beta-lactamase TEM 6.758e-13 0.51
AMPC_ENTCL ampC Beta-lactamase 7.776e-13 0.41
AMPC_ECOLI ampC Beta-lactamase 2.853e-06 0.51

Pimavanserin

5HT2A_HUMAN HTR2A 5-hydroxytryptamine receptor 2A 2.244e-05 1.00
DCNL1_HUMAN DCUN1D1 DCN1-like protein 1 4.494e-146 0.38
LPAR5_HUMAN LPAR5 Lysophosphatidic acid receptor 5 2.338e-97 0.35
Q76353_9HIV1 Integrase 1.854e-60 0.35
ADA17_RAT Adam17 Disintegrin and metalloproteinase domain-containing protein 17 5.097e-54 0.32
GIP_HUMAN GIP Gastric inhibitory polypeptide 1.687e-46 0.29
UBC12_HUMAN UBE2M NEDD8-conjugating enzyme Ubc12 4.699e-43 0.34
TRYG1_HUMAN TPSG1 Tryptase gamma 7.732e-39 0.33
5HT1F_HUMAN HTR1F 5-hydroxytryptamine receptor 1F 7.159e-38 0.32
ACACB_HUMAN ACACB Acetyl-CoA carboxylase 2 2.532e-37 0.38
SC6A5_HUMAN SLC6A5 Sodium- and chloride-dependent glycine transporter 2 1.169e-36 0.41
GLUT4_RAT Slc2a4 Solute carrier family 2, facilitated glucose transporter member 4 2.333e-36 0.29
GTR8_HUMAN SLC2A8 Solute carrier family 2, facilitated glucose transporter member 8 2.333e-36 0.29
LPAR1_HUMAN LPAR1 Lysophosphatidic acid receptor 1 6.928e-36 0.35
PPIG_HUMAN PPIG Peptidyl-prolyl cis-trans isomerase G 1.136e-34 0.29
CAC1B_HUMAN CACNA1B Voltage-dependent N-type calcium channel subunit alpha-1B 4.972e-30 0.35
DRD2_MOUSE Drd2 D(2) dopamine receptor 3.895e-29 0.33
Q95214_RABIT ACAT Acyl-CoA:cholesterol acyltransferase 1.469e-28 0.43
SC5A7_HUMAN SLC5A7 High affinity choline transporter 1 1.744e-27 0.33
PDS_SYNE7 pds 15-cis-phytoene desaturase 1.144e-25 0.33
SGMR1_MOUSE Sigmar1 Sigma non-opioid intracellular receptor 1 1.512e-25 0.33
ADRB1_RAT Adrb1 Beta-1 adrenergic receptor 6.999e-25 0.33
Q7ZJM1_9HIV1 pol Integrase 1.886e-21 0.38
Q9N6S8_PLAFA Cysteine proteinase falcipain 2a 2.143e-21 0.35
GIPR_RAT Gipr Gastric inhibitory polypeptide receptor 3.814e-21 0.34
PPIB_HUMAN PPIB Peptidyl-prolyl cis-trans isomerase B 1.924e-20 0.28
PPID_HUMAN PPID Peptidyl-prolyl cis-trans isomerase D 6.742e-20 0.29
GLR_HUMAN GCGR Glucagon receptor 3.604e-19 0.35
LKHA4_HUMAN LTA4H Leukotriene A-4 hydrolase 2.512e-18 0.35
NR1D2_HUMAN NR1D2 Nuclear receptor subfamily 1 group D member 2 2.898e-18 0.29
GLUT4_HUMAN SLC2A4 Solute carrier family 2, facilitated glucose transporter member 4 3.809e-18 0.29
Q4WLT4_ASPFU 1,3-beta-glucan synthase catalytic subunit FksP 4.879e-18 0.29
CCR5_HUMAN CCR5 C-C chemokine receptor type 5 3.355e-17 0.43
MTLR_HUMAN MLNR Motilin receptor 3.447e-17 0.34
KDM1A_HUMAN KDM1A Lysine-specific histone demethylase 1A 1.11e-16 0.44
CAC1C_RAT Cacna1c Voltage-dependent L-type calcium channel subunit alpha-1C 2.22e-16 0.32
A5A4K8_RABIT MLNR Motilin receptor 1.776e-15 0.34
CCR3_HUMAN CCR3 C-C chemokine receptor type 3 1.776e-15 0.35
O13428_CANAX GSC1 Beta-1,3-glucan synthase catalytic subunit 1 4.441e-15 0.29
GIPR_HUMAN GIPR Gastric inhibitory polypeptide receptor 8.549e-15 0.34
SMS1_HUMAN SGMS1 Phosphatidylcholine:ceramide cholinephosphotransferase 1 3.235e-13 0.32
CAC1G_HUMAN CACNA1G Voltage-dependent T-type calcium channel subunit alpha-1G 5.844e-13 0.34
CENPE_HUMAN CENPE Centromere-associated protein E 9.293e-13 0.29
B0FL73_CAVPO ADRB1 Beta-1 adrenergic receptor 1.146e-12 0.32
S1PR2_HUMAN S1PR2 Sphingosine 1-phosphate receptor 2 1.576e-12 0.33
HRH3_HUMAN HRH3 Histamine H3 receptor 2.66e-12 0.48
5HT3B_MOUSE Htr3b 5-hydroxytryptamine receptor 3B 3.091e-12 0.30
MCHR1_HUMAN MCHR1 Melanin-concentrating hormone receptor 1 3.319e-12 0.35
MRGX2_HUMAN MRGPRX2 Mas-related G-protein coupled receptor member X2 5.743e-12 0.29
ADRB1_HUMAN ADRB1 Beta-1 adrenergic receptor 8.064e-12 0.41
SCN9A_RAT Scn9a Sodium channel protein type 9 subunit alpha 1.661e-11 0.30
SCN1A_HUMAN SCN1A Sodium channel protein type 1 subunit alpha 2.203e-11 0.29
ABHD6_HUMAN ABHD6 Monoacylglycerol lipase ABHD6 3.107e-11 0.31
GPR88_HUMAN GPR88 Probable G-protein coupled receptor 88 3.508e-11 0.35
LSS_HUMAN LSS Lanosterol synthase 8.067e-11 0.33
DLDH_MYCTU lpdC Dihydrolipoyl dehydrogenase 1.446e-10 0.37
CCR2_MOUSE Ccr2 C-C chemokine receptor type 2 4.874e-10 0.29
HRH1_HUMAN HRH1 Histamine H1 receptor 5.632e-10 0.36
SCN9A_MOUSE Scn9a Sodium channel protein type 9 subunit alpha 7.806e-10 0.29
GLR_RAT Gcgr Glucagon receptor 1.061e-09 0.34
DRD5_HUMAN DRD5 D(1B) dopamine receptor 2.345e-09 0.36
CCL2_HUMAN CCL2 C-C motif chemokine 2 3.795e-09 0.29
CCR1_MOUSE Ccr1 C-C chemokine receptor type 1 5.792e-09 0.28
Q9JLY8_RAT Ccr1 C-C motif chemokine receptor 1 9.285e-09 0.28
5HT7R_HUMAN HTR7 5-hydroxytryptamine receptor 7 9.783e-09 0.36
KCNH2_HUMAN KCNH2 Potassium voltage-gated channel subfamily H member 2 1.007e-08 0.45
SQHC_ALIAD shc Squalene--hopene cyclase 1.167e-08 0.32
CCR1_HUMAN CCR1 C-C chemokine receptor type 1 1.298e-08 0.39
S6A11_MOUSE Slc6a11 Sodium- and chloride-dependent GABA transporter 3 2.242e-08 0.35
HMDH_RAT Hmgcr 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2.772e-08 0.34
MCHR1_RAT Mchr1 Melanin-concentrating hormone receptor 1 2.858e-08 0.30
TIF1A_HUMAN TRIM24 Transcription intermediary factor 1-alpha 2.983e-08 0.30
CCR2_HUMAN CCR2 C-C chemokine receptor type 2 3.256e-08 0.36
ADA33_HUMAN ADAM33 Disintegrin and metalloproteinase domain-containing protein 33 3.745e-08 0.30
MMP13_HUMAN MMP13 Collagenase 3 5.029e-08 0.38
SCYD_MAGO7 SDH1 Scytalone dehydratase 1.211e-07 0.37
ADRB3_HUMAN ADRB3 Beta-3 adrenergic receptor 1.445e-07 0.41
RCOR1_HUMAN RCOR1 REST corepressor 1 1.534e-07 0.31
DPP4_HUMAN DPP4 Dipeptidyl peptidase 4 1.789e-07 0.35
S6A12_MOUSE Slc6a12 Sodium- and chloride-dependent betaine transporter 3.352e-07 0.35
ANM6_HUMAN PRMT6 Protein arginine N-methyltransferase 6 4.202e-07 0.33
EBP_CAVPO EBP 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase 4.289e-07 0.29
SCN5A_HUMAN SCN5A Sodium channel protein type 5 subunit alpha 5.027e-07 0.32
STA5A_HUMAN STAT5A Signal transducer and activator of transcription 5A 7.227e-07 0.29
HYES_HUMAN EPHX2 Bifunctional epoxide hydrolase 2 7.318e-07 0.32
ABL1_MOUSE Abl1 Tyrosine-protein kinase ABL1 1.023e-06 0.28
TM11D_HUMAN TMPRSS11D Transmembrane protease serine 11D 1.265e-06 0.29
AMPN_PIG ANPEP Aminopeptidase N 1.282e-06 0.37
SC6A3_RAT Slc6a3 Sodium-dependent dopamine transporter 1.681e-06 0.35
PAR10_HUMAN PARP10 Protein mono-ADP-ribosyltransferase PARP10 2.157e-06 0.31
AMP1_PLAFQ M1 family aminopeptidase 2.249e-06 0.37
HDAC1_MOUSE Hdac1 Histone deacetylase 1 2.403e-06 0.31
Q9WTR4_RAT Slc6a2 Transporter 2.764e-06 0.35
S1PR2_RAT S1pr2 Sphingosine 1-phosphate receptor 2 4.596e-06 0.29
FABI_STAAR fabI Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI 5.179e-06 0.34
5HT1A_HUMAN HTR1A 5-hydroxytryptamine receptor 1A 5.438e-06 0.33
TRPM8_HUMAN TRPM8 Transient receptor potential cation channel subfamily M member 8 5.515e-06 0.30
STABP_HUMAN STAMBP STAM-binding protein 5.668e-06 0.30
S22A8_HUMAN SLC22A8 Solute carrier family 22 member 8 5.785e-06 0.29
CARM1_HUMAN CARM1 Histone-arginine methyltransferase CARM1 5.939e-06 0.33
ACOX1_RAT Acox1 Peroxisomal acyl-coenzyme A oxidase 1 7.42e-06 0.30
S1PR3_HUMAN S1PR3 Sphingosine 1-phosphate receptor 3 7.967e-06 0.34
SC6A4_RAT Slc6a4 Sodium-dependent serotonin transporter 8.762e-06 0.35
SC5A5_RAT Slc5a5 Sodium/iodide cotransporter 9.486e-06 0.31
MBTP1_HUMAN MBTPS1 Membrane-bound transcription factor site-1 protease 9.885e-06 0.29

Tapentadol

OPRM_HUMAN OPRM1 Mu-type opioid receptor 0.03182 1.00
KYNU_RAT Kynu Kynureninase 6.889e-43 0.34
G3HDX1_CRIGR Alpha-1B adrenergic receptor 5.17e-21 0.40
5HT5A_RAT Htr5a 5-hydroxytryptamine receptor 5A 1.665e-15 0.30
KYNU_HUMAN KYNU Kynureninase 1.776e-15 0.34
Q2PCB5_DICLA ca Carbonic anhydrase 2.492e-12 0.33
AOC3_HUMAN AOC3 Membrane primary amine oxidase 9.2e-11 0.31
PPO1_AGABI PPO1 Polyphenol oxidase 1 4.011e-10 0.32
S6A13_MOUSE Slc6a13 Sodium- and chloride-dependent GABA transporter 2 1.031e-07 0.29
OPRK_RAT Oprk1 Kappa-type opioid receptor 1.54e-06 0.29
ACM5_RAT Chrm5 Muscarinic acetylcholine receptor M5 3.213e-06 0.28
CBPA1_BOVIN CPA1 Carboxypeptidase A1 7.016e-06 0.30

Apremilast

PDE4B_HUMAN PDE4B cAMP-specific 3',5'-cyclic phosphodiesterase 4B 0.1322 1.00
UR2R_RAT Uts2r Urotensin-2 receptor 1.027e-80 0.45
UR2R_HUMAN UTS2R Urotensin-2 receptor 4.656e-33 0.45
P2RY2_MOUSE P2ry2 P2Y purinoceptor 2 1.097e-24 0.31
GLMU_ECOLI glmU Bifunctional protein GlmU 1.377e-21 0.33
PTPRE_HUMAN PTPRE Receptor-type tyrosine-protein phosphatase epsilon 6.661e-16 0.30
CYAA_BACAN cya Calmodulin-sensitive adenylate cyclase 3.753e-13 0.32
RXFP1_HUMAN RXFP1 Relaxin receptor 1 4.022e-11 0.30
P2RX2_RAT P2rx2 P2X purinoceptor 2 6.386e-11 0.35
FIBB_HUMAN FGB Fibrinogen beta chain 1.309e-10 0.28
TSHR_HUMAN TSHR Thyrotropin receptor 4.129e-10 0.29
ILVB_YEAST ILV2 Acetolactate synthase catalytic subunit, mitochondrial 1.06e-09 0.30
TF_HUMAN F3 Tissue factor 1.615e-09 0.30
SMCA2_HUMAN SMARCA2 Probable global transcription activator SNF2L2 8.173e-09 0.29
P2RY4_HUMAN P2RY4 P2Y purinoceptor 4 1.012e-08 0.33
FA7_HUMAN F7 Coagulation factor VII 3.722e-08 0.30
O77823_PIG PDE4A Cyclic AMP-specific phosphodiesterase SSPDE4A1A 4.148e-08 0.30
REV_HV1H2 rev Protein Rev 1.452e-07 0.29
TNFA_HUMAN TNF Tumor necrosis factor 1.716e-07 0.54
GP142_MOUSE Gpr142 Probable G-protein coupled receptor 142 4.542e-07 0.29
PTN13_HUMAN PTPN13 Tyrosine-protein phosphatase non-receptor type 13 6.332e-07 0.32

Trabectedin

SRC_HUMAN SRC Proto-oncogene tyrosine-protein kinase Src 0.93 1.00

Doxercalciferol

VDR_HUMAN VDR Vitamin D3 receptor 2.729e-245 0.80
VDR_RAT Vdr Vitamin D3 receptor 9.341e-178 0.66
VDR_BOVIN VDR Vitamin D3 receptor 1.981e-164 0.66
VDR_CHICK VDR Vitamin D3 receptor 3.772e-133 0.65
VDRA_DANRE vdra Vitamin D3 receptor A 1.533e-117 0.65
VDR_PIG VDR Vitamin D3 receptor 2.865e-81 0.65
VTDB_HUMAN GC Vitamin D-binding protein 2.865e-81 0.65
CP24A_HUMAN CYP24A1 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial 9.777e-53 0.69
CP27B_HUMAN CYP27B1 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial 4.061e-31 0.59
DHC24_HUMAN DHCR24 Delta(24)-sterol reductase 2.036e-19 0.31
NR1H4_MOUSE Nr1h4 Bile acid receptor 1.317e-07 0.37
RXRA_MOUSE Rxra Retinoic acid receptor RXR-alpha 2.104e-06 0.37
GLRA1_HUMAN GLRA1 Glycine receptor subunit alpha-1 5.439e-06 0.52

Temsirolimus

FKB1A_MOUSE Fkbp1a Peptidyl-prolyl cis-trans isomerase FKBP1A 8.6e-235 0.87
PP2BA_HUMAN PPP3CA Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform 2.772e-105 0.36
FKB1A_HUMAN FKBP1A Peptidyl-prolyl cis-trans isomerase FKBP1A 1.943e-96 0.87
FKB1B_HUMAN FKBP1B Peptidyl-prolyl cis-trans isomerase FKBP1B 2.554e-62 0.87
PDCD4_HUMAN PDCD4 Programmed cell death protein 4 1.184e-24 0.87
SO1B1_HUMAN SLCO1B1 Solute carrier organic anion transporter family member 1B1 1.276e-24 0.87
SF3B3_HUMAN SF3B3 Splicing factor 3B subunit 3 4.412e-10 0.36
FKBP5_HUMAN FKBP5 Peptidyl-prolyl cis-trans isomerase FKBP5 7.001e-10 0.87
FKBP4_HUMAN FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4 8.678e-07 0.36

Atrasentan

EDNRA_RAT Ednra Endothelin-1 receptor 4.055e-205 0.90
EDNRB_PIG EDNRB Endothelin receptor type B 5.677e-187 0.90
EDNRB_HUMAN EDNRB Endothelin receptor type B 3.202e-125 0.90
EDNRA_HUMAN EDNRA Endothelin-1 receptor 3.283e-95 0.74
BMP1_HUMAN BMP1 Bone morphogenetic protein 1 2.997e-46 0.37
CAC1S_HUMAN CACNA1S Voltage-dependent L-type calcium channel subunit alpha-1S 1.474e-31 0.31
ARBK1_BOVIN GRK2 Beta-adrenergic receptor kinase 1 4.57e-19 0.30
SHH_HUMAN SHH Sonic hedgehog protein 4.844e-18 0.29
TS1R1_HUMAN TAS1R1 Taste receptor type 1 member 1 7.532e-18 0.34
Q5TKS5_STAAU fabI Enoyl-ACP reductase 1.887e-15 0.30
MCHR1_MOUSE Mchr1 Melanin-concentrating hormone receptor 1 7.199e-13 0.35
EDNRB_RAT Ednrb Endothelin receptor type B 7.763e-11 0.32
TSPO_RAT Tspo Translocator protein 1.047e-10 0.35
VMAT2_BOVIN SLC18A2 Synaptic vesicular amine transporter 5.982e-10 0.29
EBNA1_EBVB9 EBNA1 Epstein-Barr nuclear antigen 1 1.398e-09 0.33
TSPO_HUMAN TSPO Translocator protein 5.074e-09 0.28
PLM2_PLAFA Plasmepsin-2 5.854e-09 0.32
SC5A5_RAT Slc5a5 Sodium/iodide cotransporter 2.387e-08 0.31
AOFB_MOUSE Maob Amine oxidase [flavin-containing] B 1.028e-07 0.30
AOFA_BOVIN MAOA Amine oxidase [flavin-containing] A 1.493e-07 0.33
FADS1_RAT Fads1 Acyl-CoA (8-3)-desaturase 2.227e-06 0.32

Palovarotene

RXRA_HUMAN RXRA Retinoic acid receptor RXR-alpha 1.229e-164 0.49
RXRG_MOUSE Rxrg Retinoic acid receptor RXR-gamma 1.623e-134 0.47
RXRB_MOUSE Rxrb Retinoic acid receptor RXR-beta 1.02e-131 0.47
RARB_HUMAN RARB Retinoic acid receptor beta 1.852e-123 0.54
RXRB_HUMAN RXRB Retinoic acid receptor RXR-beta 3.791e-117 0.49
RARG_HUMAN RARG Retinoic acid receptor gamma 6.111e-117 0.54
RARA_HUMAN RARA Retinoic acid receptor alpha 1.432e-111 0.54
RXRG_HUMAN RXRG Retinoic acid receptor RXR-gamma 2.012e-111 0.49
HNF4A_RAT Hnf4a Hepatocyte nuclear factor 4-alpha 7.99e-97 0.40
HNF4A_HUMAN HNF4A Hepatocyte nuclear factor 4-alpha 4.372e-86 0.40
CP26B_HUMAN CYP26B1 Cytochrome P450 26B1 2.804e-84 0.38
DCOR_MOUSE Odc1 Ornithine decarboxylase 2.126e-52 0.35
RARB_MOUSE Rarb Retinoic acid receptor beta 5.693e-52 0.41
RARA_MOUSE Rara Retinoic acid receptor alpha 3.345e-46 0.41
RXRA_MOUSE Rxra Retinoic acid receptor RXR-alpha 1.779e-39 0.41
TGM2_CAVCU TGM2 Protein-glutamine gamma-glutamyltransferase 2 6.306e-36 0.30
RARG_MOUSE Rarg Retinoic acid receptor gamma 3.166e-31 0.39
NR4A2_HUMAN NR4A2 Nuclear receptor subfamily 4 group A member 2 2.607e-30 0.38
NMDE4_RAT Grin2d Glutamate receptor ionotropic, NMDA 2D 8.587e-30 0.33
LACB_BOVIN LGB Beta-lactoglobulin 1.248e-24 0.30
CCNO_HUMAN CCNO Cyclin-O 5.889e-23 0.28
CP27B_MOUSE Cyp27b1 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial 2.278e-22 0.30
CP26A_HUMAN CYP26A1 Cytochrome P450 26A1 1.701e-18 0.40
CP24A_HUMAN CYP24A1 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial 2.442e-15 0.30
GP183_MOUSE Gpr183 G-protein coupled receptor 183 2.998e-15 0.30
NMDE3_RAT Grin2c Glutamate receptor ionotropic, NMDA 2C 1.621e-14 0.32
LPXC_AQUAE lpxC UDP-3-O-acyl-N-acetylglucosamine deacetylase 3.85e-12 0.33
RXRA_RAT Rxra Retinoic acid receptor RXR-alpha 6.166e-12 0.38
FA5_HUMAN F5 Coagulation factor V 2.943e-11 0.30
NMDZ1_RAT Grin1 Glutamate receptor ionotropic, NMDA 1 7.086e-11 0.33
GP183_HUMAN GPR183 G-protein coupled receptor 183 3.653e-10 0.30
DHCR7_HUMAN DHCR7 7-dehydrocholesterol reductase 1.012e-09 0.28
GRIA1_RAT Gria1 Glutamate receptor 1 1.59e-09 0.29
SSR5_MOUSE Sstr5 Somatostatin receptor type 5 2.877e-09 0.31
RXRB_RAT Rxrb Retinoic acid receptor RXR-beta 6.878e-08 0.37
RXRG_RAT Rxrg Retinoic acid receptor RXR-gamma 6.878e-08 0.37
SSR5_HUMAN SSTR5 Somatostatin receptor type 5 2.08e-07 0.33
KDM5A_HUMAN KDM5A Lysine-specific demethylase 5A 3.82e-07 0.36
ACES_MOUSE Ache Acetylcholinesterase 1.363e-06 0.29
P96830_MYCTO TYR_PHOSPHATASE_2 domain-containing protein 2.422e-06 0.32
S5A2_RAT Srd5a2 3-oxo-5-alpha-steroid 4-dehydrogenase 2 2.653e-06 0.30
KDM5B_HUMAN KDM5B Lysine-specific demethylase 5B 9.467e-06 0.36

Histamine

HRH3_CAVPO HRH3 Histamine H3 receptor 1.615e-160 0.73
HISX_BRUSU hisD Histidinol dehydrogenase 3.534e-132 0.42
HRH3_RAT Hrh3 Histamine H3 receptor 7.769e-121 0.58
HISX_BRAOC HDH Histidinol dehydrogenase, chloroplastic 2.332e-98 0.38
HRH4_HUMAN HRH4 Histamine H4 receptor 2.697e-89 0.73
HRH2_CAVPO HRH2 Histamine H2 receptor 7.796e-72 0.44
HRH1_CAVPO HRH1 Histamine H1 receptor 6.554e-61 0.44
HRH3_HUMAN HRH3 Histamine H3 receptor 1.517e-56 0.73
HISX_ECOLI hisD Histidinol dehydrogenase 4.009e-48 0.43
HRH2_HUMAN HRH2 Histamine H2 receptor 1.19e-44 0.50
ADA2C_RAT Adra2c Alpha-2C adrenergic receptor 3.022e-24 0.39
Q43014_PRUAV Beta-glucosidase 8.089e-24 0.29
HRH1_RAT Hrh1 Histamine H1 receptor 5.226e-18 0.35
HRH1_HUMAN HRH1 Histamine H1 receptor 3.39e-17 0.70
TAAR1_HUMAN TAAR1 Trace amine-associated receptor 1 1.865e-14 0.53
ADA1D_HUMAN ADRA1D Alpha-1D adrenergic receptor 1.109e-11 0.43
HRH2_RAT Hrh2 Histamine H2 receptor 2.594e-10 0.36
AOC1_HUMAN AOC1 Amiloride-sensitive amine oxidase [copper-containing] 4.093e-06 0.41

Sulfathiazole

SCN9A_HUMAN SCN9A Sodium channel protein type 9 subunit alpha 1.523e-124 0.53
SCN5A_HUMAN SCN5A Sodium channel protein type 5 subunit alpha 6.374e-104 0.53
AKT1_MOUSE Akt1 RAC-alpha serine/threonine-protein kinase 2.682e-74 0.35
MAP1_YEAST MAP1 Methionine aminopeptidase 1 2.808e-74 0.45
SCN3A_HUMAN SCN3A Sodium channel protein type 3 subunit alpha 4.635e-70 0.54
MAP1_ECOLI map Methionine aminopeptidase 3.356e-69 0.45
SCN9A_RAT Scn9a Sodium channel protein type 9 subunit alpha 1.249e-62 0.53
SCN3A_RAT Scn3a Sodium channel protein type 3 subunit alpha 1.18e-48 0.53
BRD4_MOUSE Brd4 Bromodomain-containing protein 4 2.376e-47 0.31
BPTF_HUMAN BPTF Nucleosome-remodeling factor subunit BPTF 7.374e-45 0.31
SCN9A_MOUSE Scn9a Sodium channel protein type 9 subunit alpha 1.521e-38 0.39
Q56D22_MACMU HSD11B1 Hydroxysteroid 11-beta dehydrogenase 1 3.917e-38 0.30
KMO_RAT Kmo Kynurenine 3-monooxygenase 8.121e-37 0.43
Q5TU56_ANOGA 1272966 Carbonic anhydrase 9.183e-35 0.52
SCN1A_RAT Scn1a Sodium channel protein type 1 subunit alpha 1.78e-34 0.43
CYNT_HELPY cynT Carbonic anhydrase 1.268e-31 0.52
CAH4_BOVIN CA4 Carbonic anhydrase 4 1.22e-28 0.52
A6YCJ1_9METZ Astrosclerin-3 5.171e-27 0.52
C0IX24_STYPI CA2 Carbonic anhydrase 5.431e-26 0.52
SMCA4_HUMAN SMARCA4 Transcription activator BRG1 2.603e-25 0.31
Q5U9J1_THAWE ca1 Delta carbonic anhydrase 3.407e-25 0.46
B2V8E3_SULSY Carbonate dehydratase 5.303e-25 0.52
B5SU02_STYPI CA Alpha carbonic anhydrase 5.303e-25 0.52
Q31FD6_HYDCU Carbonic anhydrase, alpha family 5.303e-25 0.52
MTCA2_MYCTU mtcA2 Carbonic anhydrase 2 7.392e-25 0.52
SC5A7_RAT Slc5a7 High affinity choline transporter 1 1.535e-24 0.30
PFKA_TRYCC pfk ATP-dependent 6-phosphofructokinase 1.635e-23 0.50
CAN_YEAST NCE103 Carbonic anhydrase 3.979e-22 0.52
PFKA_TRYBB pfk ATP-dependent 6-phosphofructokinase 6.246e-22 0.50
HXK4_HUMAN GCK Hexokinase-4 4.019e-21 0.36
Q5XX84_CANLF HSD11B1 11-beta-hydroxysteroid dehydrogenase type 1 5.19e-19 0.30
CAH1_HUMAN CA1 Carbonic anhydrase 1 1.355e-18 0.52
CAH2_HUMAN CA2 Carbonic anhydrase 2 4.907e-18 0.52
PPBT_BOVIN ALPL Alkaline phosphatase, tissue-nonspecific isozyme 7.07e-18 0.32
BRD7_HUMAN BRD7 Bromodomain-containing protein 7 7.596e-18 0.31
CAH9_HUMAN CA9 Carbonic anhydrase 9 2.03e-17 0.52
Q3I4V7_CRYNV CAN2 Carbonic anhydrase 1.11e-16 0.52
CAH13_MOUSE Ca13 Carbonic anhydrase 13 4.441e-16 0.52
CAH15_MOUSE Ca15 Carbonic anhydrase 15 4.441e-16 0.38
SCN1A_HUMAN SCN1A Sodium channel protein type 1 subunit alpha 6.661e-16 0.53
QCR7_HUMAN UQCRB Cytochrome b-c1 complex subunit 7 1.11e-15 0.30
SCN8A_HUMAN SCN8A Sodium channel protein type 8 subunit alpha 5.995e-15 0.39
Q6FTL6_CANGA NCE103 Carbonic anhydrase 2.309e-14 0.52
CP51_MYCTU cyp51 Lanosterol 14-alpha demethylase 5.429e-14 0.45
CAH_METTE Carbonic anhydrase 5.762e-14 0.37
CAH2_BOVIN CA2 Carbonic anhydrase 2 7.128e-14 0.37
LOX12_HUMAN ALOX12 Arachidonate 12-lipoxygenase, 12S-type 5.815e-13 0.50
MTCA1_MYCTU mtcA1 Beta-carbonic anhydrase 1 8.391e-13 0.52
S40A1_HUMAN SLC40A1 Solute carrier family 40 member 1 8.556e-13 0.34
LEF_BACAN lef Lethal factor 1.211e-12 0.32
CAH6_HUMAN CA6 Carbonic anhydrase 6 1.244e-11 0.52
BAZ2B_HUMAN BAZ2B Bromodomain adjacent to zinc finger domain protein 2B 3.859e-11 0.31
PPBI_BOVIN ALPI Intestinal-type alkaline phosphatase 7.169e-11 0.32
Q81VW8_BACAN folP Dihydropteroate synthase 1.577e-10 0.28
CAN_CANAL NCE103 Carbonic anhydrase 2.286e-10 0.52
PPIA_HUMAN PPIA Peptidyl-prolyl cis-trans isomerase A 8.728e-10 0.57
CAH5B_HUMAN CA5B Carbonic anhydrase 5B, mitochondrial 2.242e-09 0.52
HXK4_RAT Gck Hexokinase-4 1.136e-08 0.36
IKBA_HUMAN NFKBIA NF-kappa-B inhibitor alpha 1.421e-08 0.30
CAH12_HUMAN CA12 Carbonic anhydrase 12 1.686e-08 0.52
KAT2B_HUMAN KAT2B Histone acetyltransferase KAT2B 1.704e-08 0.31
SCN2A_HUMAN SCN2A Sodium channel protein type 2 subunit alpha 2.577e-08 0.53
P96878_MYCTU Probable transmembrane carbonic anhydrase (Carbonate dehydratase) (Carbonic dehydratase) 3.98e-08 0.37
FFAR2_MOUSE Ffar2 Free fatty acid receptor 2 4.168e-08 0.30
FFAR2_HUMAN FFAR2 Free fatty acid receptor 2 4.825e-08 0.30
CAH14_HUMAN CA14 Carbonic anhydrase 14 6.063e-08 0.52
METC_ECOLI metC Cystathionine beta-lyase MetC 1.106e-07 0.30
5NTD_HUMAN NT5E 5'-nucleotidase 1.802e-07 0.36
CAH5A_HUMAN CA5A Carbonic anhydrase 5A, mitochondrial 1.003e-06 0.52
P3C2G_HUMAN PIK3C2G Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma 1.285e-06 0.30
SCN4A_HUMAN SCN4A Sodium channel protein type 4 subunit alpha 2.988e-06 0.53
SRBP2_HUMAN SREBF2 Sterol regulatory element-binding protein 2 3.477e-06 0.28

Maribavir

S28A2_HUMAN SLC28A2 Sodium/nucleoside cotransporter 2 9.232e-119 0.38
CDD_MOUSE Cda Cytidine deaminase 3.183e-90 0.36
AA1R_RAT Adora1 Adenosine receptor A1 8.276e-90 0.45
AA1R_CHICK ADORA1 Adenosine receptor A1 1.515e-85 0.32
ADK_TOXGO AK Adenosine kinase 1.589e-83 0.35
ADOK_MYCTO adoK Adenosine kinase 6.979e-77 0.34
BIP_HUMAN HSPA5 Endoplasmic reticulum chaperone BiP 3.534e-72 0.42
S29A1_HUMAN SLC29A1 Equilibrative nucleoside transporter 1 2.408e-71 0.37
AA2AR_RAT Adora2a Adenosine receptor A2a 1.804e-57 0.40
AA1R_CAVPO ADORA1 Adenosine receptor A1 2.431e-54 0.45
HSP7C_HUMAN HSPA8 Heat shock cognate 71 kDa protein 4.718e-50 0.42
S28A2_RAT Slc28a2 Sodium/nucleoside cotransporter 2 2.433e-48 0.38
CDD_HUMAN CDA Cytidine deaminase 6.787e-48 0.34
NADK1_LISMF nadK1 NAD kinase 1 5.748e-39 0.31
NADK_STAAC nadK NAD kinase 5.748e-39 0.31
ADK_HUMAN ADK Adenosine kinase 7.422e-34 0.38
AA3R_HUMAN ADORA3 Adenosine receptor A3 4.354e-32 0.40
TOP1_HUMAN TOP1 DNA topoisomerase 1 4.378e-31 0.32
SC5A2_HUMAN SLC5A2 Sodium/glucose cotransporter 2 8.303e-31 0.36
AA3R_RAT Adora3 Adenosine receptor A3 1.391e-27 0.40
ADA_MOUSE Ada Adenosine deaminase 1.891e-27 0.34
ADA_BOVIN ADA Adenosine deaminase 2.097e-25 0.39
FIMH_ECOLI fimH Type 1 fimbrin D-mannose specific adhesin 6.979e-25 0.36
S29A1_RAT Slc29a1 Equilibrative nucleoside transporter 1 7.913e-25 0.31
AA1R_HUMAN ADORA1 Adenosine receptor A1 2.272e-24 0.40
AA1R_RABIT ADORA1 Adenosine receptor A1 2.567e-23 0.32
AA2AR_HUMAN ADORA2A Adenosine receptor A2a 6.68e-21 0.40
ADA_HUMAN ADA Adenosine deaminase 1.118e-19 0.34
AA3R_RABIT ADORA3 Adenosine receptor A3 1.113e-18 0.32
PYRF_YEAST URA3 Orotidine 5'-phosphate decarboxylase 5.368e-18 0.34
TYRO_HUMAN TYR Tyrosinase 6.568e-18 0.30
Q4VQ11_PIG Adenosine receptor A1 8.381e-18 0.37
PYGM_RABIT PYGM Glycogen phosphorylase, muscle form 1.11e-16 0.36
G3P_HUMAN GAPDH Glyceraldehyde-3-phosphate dehydrogenase 5.44e-15 0.36
AA2AR_CAVPO ADORA2A Adenosine receptor A2a 2.431e-14 0.38
TRPV4_HUMAN TRPV4 Transient receptor potential cation channel subfamily V member 4 1.248e-12 0.33
RNAS1_BOVIN RNASE1 Ribonuclease pancreatic 1.69e-12 0.31
DCAM_HUMAN AMD1 S-adenosylmethionine decarboxylase proenzyme 5.326e-11 0.30
PDCD4_HUMAN PDCD4 Programmed cell death protein 4 3.304e-09 0.31
AA1R_BOVIN ADORA1 Adenosine receptor A1 1.848e-07 0.38
UREA_CANEN Urease 4.098e-07 0.32
HXK2_HUMAN HK2 Hexokinase-2 1.409e-06 0.36
PYGM_HUMAN PYGM Glycogen phosphorylase, muscle form 1.666e-06 0.36
AA2BR_HUMAN ADORA2B Adenosine receptor A2b 1.915e-06 0.39
HXK1_HUMAN HK1 Hexokinase-1 5.897e-06 0.36

Udenafil

PDE5A_HUMAN PDE5A cGMP-specific 3',5'-cyclic phosphodiesterase 1.744e-112 0.53
PDE5A_RAT Pde5a cGMP-specific 3',5'-cyclic phosphodiesterase 1.903e-100 0.46
MRP5_HUMAN ABCC5 Multidrug resistance-associated protein 5 2.745e-66 0.46
PDE6C_HUMAN PDE6C Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 2.185e-63 0.50
PDE6C_BOVIN PDE6C Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 4.304e-57 0.46
DRD2_CANLF DRD2 D(2) dopamine receptor 5.94e-36 0.28
I23O2_MOUSE Ido2 Indoleamine 2,3-dioxygenase 2 1.517e-23 0.46
PDE1A_HUMAN PDE1A Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1.11e-16 0.50
HDAC6_HUMAN HDAC6 Histone deacetylase 6 2.22e-16 0.45
Q4Q5S8_LEIMA NMT Glycylpeptide N-tetradecanoyltransferase 3.331e-16 0.32
CASP3_HUMAN CASP3 Caspase-3 4.441e-14 0.34
CASP7_HUMAN CASP7 Caspase-7 5.196e-14 0.34
E1BN64_BOVIN PDE3B Phosphodiesterase 2.942e-13 0.46
PDE6A_CANLF PDE6A Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha 4.468e-13 0.28
Q388H8_TRYB2 Glycylpeptide N-tetradecanoyltransferase 3.837e-09 0.32
PDE11_HUMAN PDE11A Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A 4.161e-09 0.50
CASP9_HUMAN CASP9 Caspase-9 8.315e-09 0.30
NMT1_HUMAN NMT1 Glycylpeptide N-tetradecanoyltransferase 1 1.242e-08 0.32
PDE6A_BOVIN PDE6A Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha 5.938e-08 0.46
ATS5_HUMAN ADAMTS5 A disintegrin and metalloproteinase with thrombospondin motifs 5 1.473e-07 0.32

Acetylcysteine

LKHA4_CAVPO LTA4H Leukotriene A-4 hydrolase 4.735e-112 0.37
CBPA1_BOVIN CPA1 Carboxypeptidase A1 4.483e-93 0.62
GNPAT_HUMAN GNPAT Dihydroxyacetone phosphate acyltransferase 1.412e-66 0.42
ACE_MOUSE Ace Angiotensin-converting enzyme 6.169e-52 0.36
FOLH1_RAT Folh1 Glutamate carboxypeptidase 2 1.408e-45 0.52
SPSB2_HUMAN SPSB2 SPRY domain-containing SOCS box protein 2 1.721e-42 0.39
ACE_RABIT ACE Angiotensin-converting enzyme 3.997e-38 0.42
ACE_HUMAN ACE Angiotensin-converting enzyme 5.391e-38 0.61
S22A6_RAT Slc22a6 Solute carrier family 22 member 6 2.691e-30 0.53
GSTK1_HUMAN GSTK1 Glutathione S-transferase kappa 1 1.476e-29 0.37
NEP_RABIT MME Neprilysin 2.228e-29 0.38
AMD_RAT Pam Peptidylglycine alpha-amidating monooxygenase 1.021e-27 0.37
NALD2_HUMAN NAALAD2 N-acetylated-alpha-linked acidic dipeptidase 2 2.301e-27 0.40
ACE2_HUMAN ACE2 Angiotensin-converting enzyme 2 4.101e-27 0.33
NEP_HUMAN MME Neprilysin 5.386e-26 0.36
GGH_HUMAN GGH Gamma-glutamyl hydrolase 7.913e-25 0.31
DAPE_HAEIN dapE Succinyl-diaminopimelate desuccinylase 2.158e-24 0.30
RIR1_MOUSE Rrm1 Ribonucleoside-diphosphate reductase large subunit 2.847e-23 0.29
AMPE_HUMAN ENPEP Glutamyl aminopeptidase 4.845e-21 0.39
CFAB_HUMAN CFB Complement factor B 6.198e-21 0.34
CBPB1_PIG CPB1 Carboxypeptidase B 2.456e-20 0.31
AMD_HUMAN PAM Peptidyl-glycine alpha-amidating monooxygenase 1.29e-19 0.35
S15A2_RAT Slc15a2 Solute carrier family 15 member 2 3.577e-18 0.35
CBPA3_HUMAN CPA3 Mast cell carboxypeptidase A 4.879e-18 0.29
SCN3A_RAT Scn3a Sodium channel protein type 3 subunit alpha 7.402e-18 0.34
FOLH1_HUMAN FOLH1 Glutamate carboxypeptidase 2 1.643e-14 0.52
ECE1_RAT Ece1 Endothelin-converting enzyme 1 2.132e-14 0.36
CBPA1_HUMAN CPA1 Carboxypeptidase A1 3.786e-14 0.33
NEP_MOUSE Mme Neprilysin 3.922e-13 0.29
A3EZI9_9HEPC NS3 Genome polyprotein 2.433e-12 0.53
AMPB_HUMAN RNPEP Aminopeptidase B 3.542e-11 0.30
CHIA_SERMA chiA Chitinase A 6.573e-11 0.32
PA2G5_HUMAN PLA2G5 Calcium-dependent phospholipase A2 2.706e-10 0.29
NEP_PIG MME Neprilysin 5.982e-10 0.29
BLA1_STEMA Metallo-beta-lactamase L1 type 3 8.729e-10 0.33
ACE_RAT Ace Angiotensin-converting enzyme 2.79e-09 0.32
R1AB_SARS rep Replicase polyprotein 1ab 4.341e-09 0.33
NEP_RAT Mme Neprilysin 4.42e-09 0.35
SF3B3_HUMAN SF3B3 Splicing factor 3B subunit 3 5.223e-09 0.32
DCOR_HUMAN ODC1 Ornithine decarboxylase 3.91e-08 0.30
PA2G5_MOUSE Pla2g5 Calcium-dependent phospholipase A2 1.631e-07 0.29
AMPN_PIG ANPEP Aminopeptidase N 1.773e-07 0.39
CBPN_HUMAN CPN1 Carboxypeptidase N catalytic chain 5.365e-07 0.30
PA2GA_MOUSE Pla2g2a Phospholipase A2, membrane associated 6.707e-07 0.29
PGTB1_BOVIN PGGT1B Geranylgeranyl transferase type-1 subunit beta 7.453e-07 0.31
Q9K2N0_PSEAI blaVIM-2 Beta-lactamase class B VIM-2 1.507e-06 0.30
RIR1_HHV11 RIR1 Ribonucleoside-diphosphate reductase large subunit 2.521e-06 0.29
Q79MP6_PSEAI blaIMP-1 Beta-lactamase 6.141e-06 0.30
CAN1_HUMAN CAPN1 Calpain-1 catalytic subunit 7.712e-06 0.42
SYYC_HUMAN YARS1 Tyrosine--tRNA ligase, cytoplasmic 8.03e-06 0.29

Hexaminolevulinate

P2Y10_HUMAN P2RY10 Putative P2Y purinoceptor 10 3.235e-105 0.40
PA24B_HUMAN PLA2G4B Cytosolic phospholipase A2 beta 1.012e-101 0.37
CQSS_VIBCH cqsS CAI-1 autoinducer sensor kinase/phosphatase CqsS 4.904e-97 0.36
GP174_HUMAN GPR174 Probable G-protein coupled receptor 174 3.651e-76 0.31
LPAR4_HUMAN LPAR4 Lysophosphatidic acid receptor 4 5.764e-71 0.36
GPR34_HUMAN GPR34 Probable G-protein coupled receptor 34 1.944e-65 0.40
LPXC_AQUAE lpxC UDP-3-O-acyl-N-acetylglucosamine deacetylase 1.05e-59 0.38
TLR2_HUMAN TLR2 Toll-like receptor 2 9.987e-56 0.38
LPAR6_HUMAN LPAR6 Lysophosphatidic acid receptor 6 1.761e-54 0.36
ERG1_RAT Sqle Squalene monooxygenase 7.521e-44 0.39
LPAR4_MOUSE Lpar4 Lysophosphatidic acid receptor 4 2.281e-40 0.32
A1ZA98_DROME Jhe Carboxylic ester hydrolase 1.177e-39 0.37
LPAR3_HUMAN LPAR3 Lysophosphatidic acid receptor 3 3.521e-39 0.37
MCAT_HUMAN SLC25A20 Mitochondrial carnitine/acylcarnitine carrier protein 1.947e-38 0.30
Q95Z89_LEIMA Top1B DNA topoisomerase type IB small subunit 1.332e-36 0.29
TLR1_HUMAN TLR1 Toll-like receptor 1 3.875e-36 0.29
MPIP2_MOUSE Cdc25b M-phase inducer phosphatase 2 3.418e-33 0.41
ALF_CANAL FBA1 Fructose-bisphosphate aldolase 1.5e-32 0.43
AMD_HUMAN PAM Peptidyl-glycine alpha-amidating monooxygenase 1.29e-27 0.46
Q9GPG0_MANSE Carboxylic ester hydrolase 5.245e-27 0.33
LPAR2_HUMAN LPAR2 Lysophosphatidic acid receptor 2 1.91e-26 0.37
HYES_MOUSE Ephx2 Bifunctional epoxide hydrolase 2 3.098e-26 0.42
EST2C_MOUSE Ces2c Acylcarnitine hydrolase 5.636e-26 0.37
EST1_RABIT Liver carboxylesterase 1 2.127e-25 0.39
KPCA_RAT Prkca Protein kinase C alpha type 3.622e-25 0.39
CD14_HUMAN CD14 Monocyte differentiation antigen CD14 1.734e-23 0.29
PA2GA_RABIT PLA2G2A Phospholipase A2, membrane associated 2.847e-23 0.29
Q5HMD9_STAEQ murF UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase 4.989e-23 0.28
DXS_ECO27 dxs 1-deoxy-D-xylulose-5-phosphate synthase 5.518e-23 0.28
DXS_MYCTU dxs 1-deoxy-D-xylulose-5-phosphate synthase 5.518e-23 0.28
FAAH1_HUMAN FAAH Fatty-acid amide hydrolase 1 1.925e-22 0.54
THA_HUMAN THRA Thyroid hormone receptor alpha 2.639e-22 0.34
A85C_MYCTU fbpC Diacylglycerol acyltransferase/mycolyltransferase Ag85C 8.238e-21 0.32
THB_HUMAN THRB Thyroid hormone receptor beta 9.366e-21 0.34
TLR1_MOUSE Tlr1 Toll-like receptor 1 1.024e-20 0.29
TLR2_MOUSE Tlr2 Toll-like receptor 2 1.024e-20 0.29
PA2GC_HUMAN PLA2G2C Putative inactive group IIC secretory phospholipase A2 1.164e-20 0.32
TRPV2_RAT Trpv2 Transient receptor potential cation channel subfamily V member 2 1.22e-20 0.35
KPCL_MOUSE Prkch Protein kinase C eta type 2.737e-20 0.39
EST2_HUMAN CES2 Cocaine esterase 1.117e-19 0.39
PA2GA_RAT Pla2g2a Phospholipase A2, membrane associated 3.993e-19 0.29
Q9BJJ9_PLAFA FabI Enoyl-ACP reductase 2.898e-18 0.29
GSTM1_HUMAN GSTM1 Glutathione S-transferase Mu 1 7.088e-18 0.28
AMPN_ECOLI pepN Aminopeptidase N 7.502e-18 0.28
DXS_ECOLI dxs 1-deoxy-D-xylulose-5-phosphate synthase 8.104e-18 0.28
LPAR1_HUMAN LPAR1 Lysophosphatidic acid receptor 1 2.624e-17 0.37
EST1_HUMAN CES1 Liver carboxylesterase 1 1.554e-15 0.39
LY96_HUMAN LY96 Lymphocyte antigen 96 3.22e-15 0.29
LPAR1_MOUSE Lpar1 Lysophosphatidic acid receptor 1 6.106e-15 0.28
NAAA_HUMAN NAAA N-acylethanolamine-hydrolyzing acid amidase 2.576e-14 0.38
Q9RMS5_PSEAI phzR LuxR family transcriptional regulator 3.597e-14 0.30
PA2G5_MOUSE Pla2g5 Calcium-dependent phospholipase A2 4.163e-14 0.29
KPCA_HUMAN PRKCA Protein kinase C alpha type 7.605e-14 0.42
LUXP_VIBHA luxP Autoinducer 2-binding periplasmic protein LuxP 2.335e-13 0.30
PA2GA_MOUSE Pla2g2a Phospholipase A2, membrane associated 6.64e-13 0.29
NAAA_RAT Naaa N-acylethanolamine-hydrolyzing acid amidase 1.873e-12 0.35
FAAH1_MOUSE Faah Fatty-acid amide hydrolase 1 3.854e-12 0.33
GPR34_MOUSE Gpr34 Probable G-protein coupled receptor 34 5.856e-12 0.35
Q95214_RABIT ACAT Acyl-CoA:cholesterol acyltransferase 1.146e-11 0.38
KPCA_BOVIN PRKCA Protein kinase C alpha type 1.768e-11 0.39
CP74A_ARATH CYP74A Allene oxide synthase, chloroplastic 2.335e-11 0.33
KPCD_MOUSE Prkcd Protein kinase C delta type 4.543e-11 0.46
KCNQ1_CAVPO KCNQ1 Potassium voltage-gated channel subfamily KQT member 1 7.078e-11 0.31
MGLL_RAT Mgll Monoglyceride lipase 1.03e-10 0.31
HYEP_MOUSE Ephx1 Epoxide hydrolase 1 2.486e-10 0.47
FABPH_HUMAN FABP3 Fatty acid-binding protein, heart 3.213e-10 0.34
PA2G5_HUMAN PLA2G5 Calcium-dependent phospholipase A2 3.518e-10 0.29
MPIP3_HUMAN CDC25C M-phase inducer phosphatase 3 6.126e-10 0.30
EST1_PIG Liver carboxylesterase 7.193e-10 0.37
PAOX_HUMAN PAOX Peroxisomal N(1)-acetyl-spermine/spermidine oxidase 7.541e-10 0.29
GGPPS_HUMAN GGPS1 Geranylgeranyl pyrophosphate synthase 8.437e-10 0.30
VEGFA_HUMAN VEGFA Vascular endothelial growth factor A 1.018e-09 0.28
ENPP2_HUMAN ENPP2 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 1.161e-09 0.36
HYEP_HUMAN EPHX1 Epoxide hydrolase 1 1.435e-09 0.47
DYN1_HUMAN DNM1 Dynamin-1 1.821e-09 0.37
PA21B_PIG PLA2G1B Phospholipase A2, major isoenzyme 2.755e-09 0.31
Q965D6_PLAFA fabG 3-oxoacyl-acyl-carrier protein reductase 2.791e-09 0.29
SPHK2_MOUSE Sphk2 Sphingosine kinase 2 6.397e-09 0.32
S1PR5_HUMAN S1PR5 Sphingosine 1-phosphate receptor 5 9.348e-09 0.34
LASR_PSEAE lasR Transcriptional activator protein LasR 1.885e-08 0.30
PTAFR_CAVPO PTAFR Platelet-activating factor receptor 6.362e-08 0.33
Q965D7_PLAFA fabZ Beta-hydroxyacyl-ACP dehydratase 8.352e-08 0.29
PLCG2_HUMAN PLCG2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 9.002e-08 0.29
S22A8_HUMAN SLC22A8 Solute carrier family 22 member 8 1.755e-07 0.38
STS_HUMAN STS Steryl-sulfatase 2.2e-07 0.35
S1PR3_HUMAN S1PR3 Sphingosine 1-phosphate receptor 3 2.956e-07 0.35
HYES_HUMAN EPHX2 Bifunctional epoxide hydrolase 2 4.119e-07 0.42
Q197X6_TOXGO FPPS Farnesyl diphosphate synthase 6.689e-07 0.28
PA2GD_HUMAN PLA2G2D Group IID secretory phospholipase A2 8.227e-07 0.29
DHB3_HUMAN HSD17B3 Testosterone 17-beta-dehydrogenase 3 1.151e-06 0.29
FAAH1_RAT Faah Fatty-acid amide hydrolase 1 1.327e-06 0.38
MPIP1_HUMAN CDC25A M-phase inducer phosphatase 1 2.841e-06 0.30
NOD1_HUMAN NOD1 Nucleotide-binding oligomerization domain-containing protein 1 3.331e-06 0.41
S22A6_HUMAN SLC22A6 Solute carrier family 22 member 6 4.592e-06 0.38
DPOLB_HUMAN POLB DNA polymerase beta 5.675e-06 0.35
PA2GA_HUMAN PLA2G2A Phospholipase A2, membrane associated 6.697e-06 0.38
ACM5_HUMAN CHRM5 Muscarinic acetylcholine receptor M5 8.207e-06 0.29
SOAT1_RAT Soat1 Sterol O-acyltransferase 1 9.074e-06 0.31
MGLL_MOUSE Mgll Monoglyceride lipase 9.337e-06 0.29

Elacestrant

MTR1B_CHICK Melatonin receptor type 1B 4.563e-84 0.34
CP24A_RAT Cyp24a1 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial 7.127e-30 0.43
NQO2_HUMAN NQO2 Ribosyldihydronicotinamide dehydrogenase [quinone] 8.839e-18 0.35
CALM1_HUMAN CALM1 Calmodulin-1 4.521e-08 0.28
Q49PX0_9POXV N1L N1L 4.521e-08 0.28
MMP26_HUMAN MMP26 Matrix metalloproteinase-26 2.362e-07 0.29
MMP15_HUMAN MMP15 Matrix metalloproteinase-15 7.112e-06 0.29

Elafibranor

SDF1_HUMAN CXCL12 Stromal cell-derived factor 1 3.237e-79 0.39
TNR1A_HUMAN TNFRSF1A Tumor necrosis factor receptor superfamily member 1A 2.861e-56 0.39
CYSP_PLAFA Trophozoite cysteine proteinase 3.687e-28 0.35
CP1B1_HUMAN CYP1B1 Cytochrome P450 1B1 1.942e-27 0.37
Q26964_TRYCR TCTS-154 Trans-sialidase 8.092e-26 0.32
CP1A1_HUMAN CYP1A1 Cytochrome P450 1A1 2.333e-24 0.37
Q5VLE3_EMEND rmtA RmtA 4.11e-19 0.30
ABCG2_HUMAN ABCG2 Broad substrate specificity ATP-binding cassette transporter ABCG2 4.419e-19 0.38
FABPI_HUMAN FABP2 Fatty acid-binding protein, intestinal 3.774e-17 0.33
NLRP1_HUMAN NLRP1 NACHT, LRR and PYD domains-containing protein 1 1.421e-14 0.32
RARB_MOUSE Rarb Retinoic acid receptor beta 9.481e-14 0.32
RARA_MOUSE Rara Retinoic acid receptor alpha 2.834e-12 0.32
YOPH_YEREN yopH Tyrosine-protein phosphatase YopH 3.63e-12 0.30
P96830_MYCTO TYR_PHOSPHATASE_2 domain-containing protein 4.888e-12 0.34
FABPL_RAT Fabp1 Fatty acid-binding protein, liver 2.17e-10 0.33
Q9ZTP8_MAIZE hd1b Histone deacetylase 1.072e-09 0.32
TBB1_HUMAN TUBB1 Tubulin beta-1 chain 1.823e-09 0.33
LOX5_RAT Alox5 Arachidonate 5-lipoxygenase 3.198e-09 0.37
PPARD_HUMAN PPARD Peroxisome proliferator-activated receptor delta 8.32e-09 0.35
HAOX1_HUMAN HAO1 Hydroxyacid oxidase 1 1.006e-08 0.33
P90584_PLAFA Pfmrk MO15-related protein kinase Pfmrk 1.179e-08 0.34
PPARA_HUMAN PPARA Peroxisome proliferator-activated receptor alpha 1.867e-08 0.40
RARG_MOUSE Rarg Retinoic acid receptor gamma 3.053e-07 0.30
O49150_SOLTU Lipoxygenase 9.875e-07 0.33
AOFB_HUMAN MAOB Amine oxidase [flavin-containing] B 1.612e-06 0.41
NORA_STAAU norA Quinolone resistance protein NorA 2.048e-06 0.31
COMT_RAT Comt Catechol O-methyltransferase 4.189e-06 0.31

Ataluren

AHR_MOUSE Ahr Aryl hydrocarbon receptor 4.201e-78 0.46
IF4E_HUMAN EIF4E Eukaryotic translation initiation factor 4E 1.218e-77 0.41
PYRD_HUMAN DHODH Dihydroorotate dehydrogenase (quinone), mitochondrial 4.184e-65 0.39
HDAC4_HUMAN HDAC4 Histone deacetylase 4 8.441e-63 0.43
S1PR1_HUMAN S1PR1 Sphingosine 1-phosphate receptor 1 7.597e-57 0.42
LUCI_PHOPE Luciferin 4-monooxygenase 2.565e-52 0.53
BAP1_HUMAN BAP1 Ubiquitin carboxyl-terminal hydrolase BAP1 2.433e-48 0.38
ACHA5_HUMAN CHRNA5 Neuronal acetylcholine receptor subunit alpha-5 3.624e-43 0.38
DHB14_HUMAN HSD17B14 17-beta-hydroxysteroid dehydrogenase 14 9.498e-41 0.34
ETHR_MYCTU ethR HTH-type transcriptional regulator EthR 1.703e-38 0.38
GRM5_HUMAN GRM5 Metabotropic glutamate receptor 5 4.292e-36 0.42
COX1_SHEEP MT-CO1 Cytochrome c oxidase subunit 1 1.377e-35 0.28
KMO_HUMAN KMO Kynurenine 3-monooxygenase 5.519e-31 0.46
GPR52_HUMAN GPR52 G-protein coupled receptor 52 5.754e-31 0.31
ACMSD_HUMAN ACMSD 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase 5.798e-31 0.33
S1PR1_RAT S1pr1 Sphingosine 1-phosphate receptor 1 2.853e-28 0.33
PE2R1_HUMAN PTGER1 Prostaglandin E2 receptor EP1 subtype 1.177e-25 0.39
UROK_PIG PLAU Urokinase-type plasminogen activator 6.731e-25 0.31
AK1C3_HUMAN AKR1C3 Aldo-keto reductase family 1 member C3 3.582e-24 0.37
BLAB_SERMA Metallo-beta-lactamase type 2 6.243e-24 0.29
PTPRF_HUMAN PTPRF Receptor-type tyrosine-protein phosphatase F 1.15e-23 0.34
S1PR5_HUMAN S1PR5 Sphingosine 1-phosphate receptor 5 2.144e-22 0.42
KDM4C_HUMAN KDM4C Lysine-specific demethylase 4C 2.312e-20 0.38
COX2_SHEEP MT-CO2 Cytochrome c oxidase subunit 2 2.958e-20 0.28
LUCI_PHOPY Luciferin 4-monooxygenase 7.748e-20 0.74
SENP8_HUMAN SENP8 Sentrin-specific protease 8 1.61e-19 0.51
S1PR1_MOUSE S1pr1 Sphingosine 1-phosphate receptor 1 4.789e-19 0.33
KDM5B_HUMAN KDM5B Lysine-specific demethylase 5B 5.735e-19 0.38
S1PR3_HUMAN S1PR3 Sphingosine 1-phosphate receptor 3 6.864e-19 0.40
CPT1A_RAT Cpt1a Carnitine O-palmitoyltransferase 1, liver isoform 1.361e-18 0.41
SENP7_HUMAN SENP7 Sentrin-specific protease 7 2.227e-18 0.51
CPT1A_HUMAN CPT1A Carnitine O-palmitoyltransferase 1, liver isoform 2.617e-18 0.41
LYAM1_HUMAN SELL L-selectin 1.093e-17 0.31
Q9K2N0_PSEAI blaVIM-2 Beta-lactamase class B VIM-2 1.462e-17 0.29
HDAC6_HUMAN HDAC6 Histone deacetylase 6 1.808e-17 0.43
KDM5A_HUMAN KDM5A Lysine-specific demethylase 5A 2.567e-17 0.38
KDM2A_HUMAN KDM2A Lysine-specific demethylase 2A 4.067e-17 0.33
GABT_RAT Abat 4-aminobutyrate aminotransferase, mitochondrial 4.167e-17 0.35
AAKG1_HUMAN PRKAG1 5'-AMP-activated protein kinase subunit gamma-1 1.11e-16 0.32
NR1H4_HUMAN NR1H4 Bile acid receptor 1.11e-16 0.62
SENP6_HUMAN SENP6 Sentrin-specific protease 6 3.331e-16 0.51
AAPK2_HUMAN PRKAA2 5'-AMP-activated protein kinase catalytic subunit alpha-2 4.441e-16 0.32
FABPH_HUMAN FABP3 Fatty acid-binding protein, heart 4.441e-16 0.37
GRIK1_RAT Grik1 Glutamate receptor ionotropic, kainate 1 6.661e-16 0.34
SKN1_CAEEL skn-1 Protein skinhead-1 2.554e-15 0.39
P2Y14_MOUSE P2ry14 P2Y purinoceptor 14 3.22e-15 0.30
PLCG2_HUMAN PLCG2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 3.997e-15 0.30
AAKB1_HUMAN PRKAB1 5'-AMP-activated protein kinase subunit beta-1 4.774e-15 0.32
KISSR_HUMAN KISS1R KiSS-1 receptor 5.329e-15 0.35
ERN1_HUMAN ERN1 Serine/threonine-protein kinase/endoribonuclease IRE1 9.326e-15 0.41
PAI1_HUMAN SERPINE1 Plasminogen activator inhibitor 1 2.498e-14 0.37
KDM4E_HUMAN KDM4E Lysine-specific demethylase 4E 4.119e-14 0.34
AURKA_MOUSE Aurka Aurora kinase A 5.473e-14 0.31
KDM4A_HUMAN KDM4A Lysine-specific demethylase 4A 1.349e-13 0.34
S1PR4_HUMAN S1PR4 Sphingosine 1-phosphate receptor 4 6.632e-13 0.39
AK1C2_HUMAN AKR1C2 Aldo-keto reductase family 1 member C2 7.268e-13 0.35
PPGB_HUMAN CTSA Lysosomal protective protein 5.763e-12 0.33
REST_BORBU resT Telomere resolvase ResT 6.139e-12 0.29
FABP4_HUMAN FABP4 Fatty acid-binding protein, adipocyte 6.822e-12 0.37
HAOX1_MOUSE Hao1 Hydroxyacid oxidase 1 8.017e-12 0.29
OX1R_HUMAN HCRTR1 Orexin receptor type 1 1.061e-11 0.34
KDM5C_HUMAN KDM5C Lysine-specific demethylase 5C 1.896e-11 0.33
PE2R3_HUMAN PTGER3 Prostaglandin E2 receptor EP3 subtype 2.106e-11 0.38
KDM3A_HUMAN KDM3A Lysine-specific demethylase 3A 3.372e-11 0.33
CSK22_HUMAN CSNK2A2 Casein kinase II subunit alpha' 3.503e-11 0.40
PE2R1_RAT Ptger1 Prostaglandin E2 receptor EP1 subtype 4.158e-11 0.37
LAT_MYCTU lat Probable L-lysine-epsilon aminotransferase 4.775e-11 0.32
Q2PCB5_DICLA ca Carbonic anhydrase 5.087e-11 0.30
OX2R_HUMAN HCRTR2 Orexin receptor type 2 7.204e-11 0.34
GSTP1_HUMAN GSTP1 Glutathione S-transferase P 8.784e-11 0.30
CSK2B_HUMAN CSNK2B Casein kinase II subunit beta 1.372e-10 0.40
FA5_HUMAN F5 Coagulation factor V 1.522e-10 0.28
B5ATN6_PSEAI lpxC UDP-3-O-acyl-N-acetylglucosamine deacetylase 2.24e-10 0.32
DCK_HUMAN DCK Deoxycytidine kinase 3.147e-10 0.36
FABP5_HUMAN FABP5 Fatty acid-binding protein 5 3.209e-10 0.37
HXK2_HUMAN HK2 Hexokinase-2 4.475e-10 0.29
NPY2R_HUMAN NPY2R Neuropeptide Y receptor type 2 7.496e-10 0.33
LYAM3_HUMAN SELP P-selectin 8.6e-10 0.31
FABPL_RAT Fabp1 Fatty acid-binding protein, liver 1.206e-09 0.30
LDHA_HUMAN LDHA L-lactate dehydrogenase A chain 1.313e-09 0.38
AK1C1_HUMAN AKR1C1 Aldo-keto reductase family 1 member C1 2.198e-09 0.35
S22A6_HUMAN SLC22A6 Solute carrier family 22 member 6 2.443e-09 0.30
HPSE_HUMAN HPSE Heparanase 2.831e-09 0.34
HXK1_HUMAN HK1 Hexokinase-1 4.308e-09 0.29
TTHY_HUMAN TTR Transthyretin 4.929e-09 0.34
R1AB_SARS rep Replicase polyprotein 1ab 5.04e-09 0.33
PDK2_HUMAN PDK2 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 1.423e-08 0.42
UFO_HUMAN AXL Tyrosine-protein kinase receptor UFO 3.008e-08 0.38
HPGDS_HUMAN HPGDS Hematopoietic prostaglandin D synthase 4.141e-08 0.34
Q6TUJ4_PSEAI blaIMP-1 Metallo beta-lactamase 4.633e-08 0.30
TRPV3_HUMAN TRPV3 Transient receptor potential cation channel subfamily V member 3 5.7e-08 0.34
PTN1_RAT Ptpn1 Tyrosine-protein phosphatase non-receptor type 1 6.729e-08 0.29
PTN5_HUMAN PTPN5 Tyrosine-protein phosphatase non-receptor type 5 8.612e-08 0.31
FOLH1_HUMAN FOLH1 Glutamate carboxypeptidase 2 1.482e-07 0.38
FABH_ENTFA fabH 3-oxoacyl-[acyl-carrier-protein] synthase 3 1.892e-07 0.31
PGH1_RAT Ptgs1 Prostaglandin G/H synthase 1 2.163e-07 0.30
ILVB_ARATH ALS Acetolactate synthase, chloroplastic 2.93e-07 0.30
PA2GD_HUMAN PLA2G2D Group IID secretory phospholipase A2 4.296e-07 0.30
AK1C4_HUMAN AKR1C4 Aldo-keto reductase family 1 member C4 5.533e-07 0.28
UPAR_HUMAN PLAUR Urokinase plasminogen activator surface receptor 5.904e-07 0.28
PTN2_HUMAN PTPN2 Tyrosine-protein phosphatase non-receptor type 2 7.372e-07 0.34
RHOA_HUMAN RHOA Transforming protein RhoA 7.93e-07 0.40
Q70GC6_9HEPC NS5B RNA-directed RNA polymerase 8.414e-07 0.32
5HT1D_PIG HTR1D 5-hydroxytryptamine receptor 1D 9.48e-07 0.35
CYAA_BACAN cya Calmodulin-sensitive adenylate cyclase 9.501e-07 0.31
HRH3_RAT Hrh3 Histamine H3 receptor 1.434e-06 0.37
CASP3_HUMAN CASP3 Caspase-3 1.548e-06 0.51
Q8ST54_TRYCR HK Phosphotransferase 1.683e-06 0.29
Q6QLK5_9HIV1 env Envelope glycoprotein gp160 1.777e-06 0.30
KCNQ2_MOUSE Kcnq2 Potassium voltage-gated channel subfamily KQT member 2 1.858e-06 0.28
S5A2_RAT Srd5a2 3-oxo-5-alpha-steroid 4-dehydrogenase 2 1.886e-06 0.31
ACM5_RAT Chrm5 Muscarinic acetylcholine receptor M5 2.123e-06 0.29
FES_HUMAN FES Tyrosine-protein kinase Fes/Fps 2.125e-06 0.32
MK14_RAT Mapk14 Mitogen-activated protein kinase 14 2.158e-06 0.31
HDAC1_HUMAN HDAC1 Histone deacetylase 1 2.43e-06 0.43
PI2R_RAT Ptgir Prostacyclin receptor 2.486e-06 0.29
TCMO_POPKI CYP73A16 Trans-cinnamate 4-monooxygenase 3.596e-06 0.33
EST1_HUMAN CES1 Liver carboxylesterase 1 3.632e-06 0.31
TSPO_RAT Tspo Translocator protein 3.883e-06 0.34
PASK_HUMAN PASK PAS domain-containing serine/threonine-protein kinase 3.933e-06 0.30
AGP1_YEAST AGP1 General amino acid permease AGP1 4.687e-06 0.30
XDH_BOVIN XDH Xanthine dehydrogenase/oxidase 5.296e-06 0.34
DUS22_HUMAN DUSP22 Dual specificity protein phosphatase 22 5.567e-06 0.28
NPY5R_MOUSE Npy5r Neuropeptide Y receptor type 5 5.652e-06 0.37
PPARG_HUMAN PPARG Peroxisome proliferator-activated receptor gamma 6.664e-06 0.33
KLF5_HUMAN KLF5 Krueppel-like factor 5 7.038e-06 0.36
FADS1_RAT Fads1 Acyl-CoA (8-3)-desaturase 8.827e-06 0.29

Spiramycin

A5A4K8_RABIT MLNR Motilin receptor 2.535e-74 0.33
ABCBB_HUMAN ABCB11 Bile salt export pump 7.223e-12 0.29

Trofinetide

Q9I056_PSEAE cpg2 Carboxypeptidase G2 3.087e-71 0.33
NALD2_HUMAN NAALAD2 N-acetylated-alpha-linked acidic dipeptidase 2 2.795e-56 0.41
GGH_HUMAN GGH Gamma-glutamyl hydrolase 1.519e-49 0.34
FOLH1_RAT Folh1 Glutamate carboxypeptidase 2 2.213e-46 0.41
GNPAT_HUMAN GNPAT Dihydroxyacetone phosphate acyltransferase 4.308e-38 0.32
DLG4_HUMAN DLG4 Disks large homolog 4 1.429e-31 0.32
FOLH1_HUMAN FOLH1 Glutamate carboxypeptidase 2 2.792e-28 0.41
ITB7_HUMAN ITGB7 Integrin beta-7 4.825e-26 0.35
S15A2_HUMAN SLC15A2 Solute carrier family 15 member 2 1.114e-23 0.29
HMDH_MESAU HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase 6.741e-19 0.30
TYSY_RAT Tyms Thymidylate synthase 3.72e-18 0.29
GASR_RAT Cckbr Gastrin/cholecystokinin type B receptor 4.857e-18 0.32
ITA4_HUMAN ITGA4 Integrin alpha-4 2.895e-17 0.35
LY96_HUMAN LY96 Lymphocyte antigen 96 4.441e-16 0.31
ITB1_HUMAN ITGB1 Integrin beta-1 3.22e-15 0.34
CBPB2_HUMAN CPB2 Carboxypeptidase B2 2.577e-12 0.30
RIR1_HHV11 RIR1 Ribonucleoside-diphosphate reductase large subunit 4.092e-12 0.30
GASR_HUMAN CCKBR Gastrin/cholecystokinin type B receptor 2.64e-10 0.34
PUR2_MOUSE Gart Trifunctional purine biosynthetic protein adenosine-3 6.394e-10 0.28
S15A2_RAT Slc15a2 Solute carrier family 15 member 2 7.778e-09 0.29
ACE_HUMAN ACE Angiotensin-converting enzyme 8.767e-06 0.33

Sugammadex

LUXS_BACSU luxS S-ribosylhomocysteine lyase 8.284e-65 0.41
KMT5C_HUMAN KMT5C Histone-lysine N-methyltransferase KMT5C 1.377e-35 0.28
SETB1_HUMAN SETDB1 Histone-lysine N-methyltransferase SETDB1 1.377e-35 0.28
DNM3B_HUMAN DNMT3B DNA (cytosine-5)-methyltransferase 3B 1.465e-10 0.28
SUV91_HUMAN SUV39H1 Histone-lysine N-methyltransferase SUV39H1 1.577e-10 0.28
KMT2A_HUMAN KMT2A Histone-lysine N-methyltransferase 2A 5.192e-08 0.28
BHMT1_HUMAN BHMT Betaine--homocysteine S-methyltransferase 1 9.771e-08 0.30
EZH1_HUMAN EZH1 Histone-lysine N-methyltransferase EZH1 1.166e-06 0.28
INMT_HUMAN INMT Indolethylamine N-methyltransferase 1.166e-06 0.28

Rufinamide

TGM2_CAVCU TGM2 Protein-glutamine gamma-glutamyltransferase 2 5.15e-62 0.34
FABP4_RAT Fabp4 Fatty acid-binding protein, adipocyte 7.04e-23 0.28
KCNN4_HUMAN KCNN4 Intermediate conductance calcium-activated potassium channel protein 4 3.104e-13 0.30
THYX_PBCV1 Probable flavin-dependent thymidylate synthase 3.23e-13 0.29
CD38_HUMAN CD38 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 3.64e-11 0.33
KLKB1_HUMAN KLKB1 Plasma kallikrein 7.494e-11 0.56
PAR15_HUMAN PARP15 Protein mono-ADP-ribosyltransferase PARP15 2.659e-10 0.30
KDM3A_HUMAN KDM3A Lysine-specific demethylase 3A 3.144e-10 0.28
ADA_HUMAN ADA Adenosine deaminase 2.817e-09 0.29
C1S_HUMAN C1S Complement C1s subcomponent 7.314e-09 0.33
PDE7A_HUMAN PDE7A High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A 7.576e-09 0.34
GNRHR_HUMAN GNRHR Gonadotropin-releasing hormone receptor 2.665e-08 0.34
EED_HUMAN EED Polycomb protein EED 7.163e-08 0.33
GRM2_HUMAN GRM2 Metabotropic glutamate receptor 2 4.085e-07 0.40
KCMA1_HUMAN KCNMA1 Calcium-activated potassium channel subunit alpha-1 8.841e-07 0.30
PDE4A_HUMAN PDE4A cAMP-specific 3',5'-cyclic phosphodiesterase 4A 1.144e-06 0.34
NAMPT_MOUSE Nampt Nicotinamide phosphoribosyltransferase 2.07e-06 0.28
KDM2A_HUMAN KDM2A Lysine-specific demethylase 2A 2.452e-06 0.34
Q72547_9HIV1 pol Reverse transcriptase/RNaseH 2.708e-06 0.43
PAR10_HUMAN PARP10 Protein mono-ADP-ribosyltransferase PARP10 2.721e-06 0.30
KDM5C_HUMAN KDM5C Lysine-specific demethylase 5C 4.546e-06 0.34
B5ATN6_PSEAI lpxC UDP-3-O-acyl-N-acetylglucosamine deacetylase 5.201e-06 0.33

Droxidopa

ADA2A_MOUSE Adra2a Alpha-2A adrenergic receptor 6.014e-59 0.47
ADA2C_MOUSE Adra2c Alpha-2C adrenergic receptor 6.014e-59 0.47
TY3H_RAT Th Tyrosine 3-monooxygenase 5.965e-45 0.36
Q06347_9HIV2 reverse transcriptase Reverse transcriptase 3.092e-44 0.35
KYNU_RAT Kynu Kynureninase 6.315e-44 0.35
GLT_PYRHO Glutamate transporter homolog 4.474e-39 0.31
EAA2_HUMAN SLC1A2 Excitatory amino acid transporter 2 4.564e-37 0.35
MGRA_STAAU mgrA HTH-type transcriptional regulator MgrA 1.097e-35 0.28
EAA3_HUMAN SLC1A1 Excitatory amino acid transporter 3 1.052e-34 0.35
EAA4_RAT Slc1a6 Excitatory amino acid transporter 4 5.897e-34 0.35
EAA1_HUMAN SLC1A3 Excitatory amino acid transporter 1 1.131e-32 0.35
CA2D1_MOUSE Cacna2d1 Voltage-dependent calcium channel subunit alpha-2/delta-1 7.783e-30 0.36
BLAB_BACCE Metallo-beta-lactamase type 2 1.914e-25 0.29
ARP19_RAT Arpp19 cAMP-regulated phosphoprotein 19 3.516e-24 0.30
ADRB1_MOUSE Adrb1 Beta-1 adrenergic receptor 1.783e-22 0.38
TY3H_HUMAN TH Tyrosine 3-monooxygenase 2.457e-22 0.36
ADRB2_BOVIN ADRB2 Beta-2 adrenergic receptor 1.634e-21 0.47
LAT1_HUMAN SLC7A5 Large neutral amino acids transporter small subunit 1 1.816e-20 0.33
Q39829_SOYBN Lipoxygenase 2.318e-20 0.32
ADRB2_MESAU ADRB2 Beta-2 adrenergic receptor 1.11e-16 0.38
KYNU_HUMAN KYNU Kynureninase 7.772e-16 0.35
TYRO_MOUSE Tyr Tyrosinase 1.998e-15 0.38
Q2PCB5_DICLA ca Carbonic anhydrase 1.998e-14 0.39
ADRB2_CANLF ADRB2 Beta-2 adrenergic receptor 3.653e-14 0.47
IBP3_HUMAN IGFBP3 Insulin-like growth factor-binding protein 3 5.151e-14 0.31
Q7ZJM1_9HIV1 pol Integrase 6.917e-14 0.38
HAOX1_MOUSE Hao1 Hydroxyacid oxidase 1 3.235e-13 0.32
A0A0C7ACN7_PSEAI pqsD 3-oxoacyl-ACP synthase 3.239e-13 0.30
GRM8_HUMAN GRM8 Metabotropic glutamate receptor 8 4.053e-12 0.37
RNH1_HUMAN RNASEH1 Ribonuclease H1 6.269e-12 0.35
ADRB3_RAT Adrb3 Beta-3 adrenergic receptor 4.395e-11 0.47
KDM4E_HUMAN KDM4E Lysine-specific demethylase 4E 6.606e-11 0.34
ADRB2_RAT Adrb2 Beta-2 adrenergic receptor 1.073e-10 0.47
SYYC_HUMAN YARS1 Tyrosine--tRNA ligase, cytoplasmic 1.141e-10 0.29
Q8I2J3_PLAF7 M18 aspartyl aminopeptidase 1.811e-09 0.39
COMT_PIG COMT Catechol O-methyltransferase 2.247e-09 0.29
LOX15_RABIT ALOX15 Arachidonate 15-lipoxygenase 2.754e-09 0.46
XCT_HUMAN SLC7A11 Cystine/glutamate transporter 4.299e-09 0.36
1433G_HUMAN YWHAG 14-3-3 protein gamma 1.489e-08 0.30
ADRB1_RAT Adrb1 Beta-1 adrenergic receptor 2.726e-08 0.47
LOX1_SOYBN LOX1.1 Seed linoleate 13S-lipoxygenase-1 4.928e-08 0.34
Q49PX0_9POXV N1L N1L 4.951e-08 0.28
GRM6_RAT Grm6 Metabotropic glutamate receptor 6 2.305e-07 0.37
ADA2B_RAT Adra2b Alpha-2B adrenergic receptor 2.829e-07 0.47
CBPN_HUMAN CPN1 Carboxypeptidase N catalytic chain 4.206e-07 0.30
GRM6_HUMAN GRM6 Metabotropic glutamate receptor 6 5.522e-07 0.37
O49150_SOLTU Lipoxygenase 6.864e-07 0.34
POLG_DEN2P Genome polyprotein 1.122e-06 0.28
TYRO_HUMAN TYR Tyrosinase 2.007e-06 0.30
GRM8_RAT Grm8 Metabotropic glutamate receptor 8 2.997e-06 0.37
ERCC1_HUMAN ERCC1 DNA excision repair protein ERCC-1 3.181e-06 0.32
XPF_HUMAN ERCC4 DNA repair endonuclease XPF 3.181e-06 0.32
BLA2_BACCE blm Metallo-beta-lactamase type 2 7.112e-06 0.29
PCNA_HUMAN PCNA Proliferating cell nuclear antigen 7.581e-06 0.29
FOLH1_HUMAN FOLH1 Glutamate carboxypeptidase 2 9.969e-06 0.30

Oxymetholone

SHBG_HUMAN SHBG Sex hormone-binding globulin 1.193e-55 0.61
G6PD_HUMAN G6PD Glucose-6-phosphate 1-dehydrogenase 1.635e-50 0.35
NR1I3_MOUSE Nr1i3 Nuclear receptor subfamily 1 group I member 3 3.637e-41 0.38
SHBG_RAT Shbg Sex hormone-binding globulin 1.125e-31 0.39
CBG_HUMAN SERPINA6 Corticosteroid-binding globulin 2.118e-31 0.39
Q9GRG7_9TRYP g6pd Glucose-6-phosphate 1-dehydrogenase 1.891e-27 0.34
ANDR_RAT Ar Androgen receptor 3.969e-26 0.62
Q690N0_BOVIN PGR Progesterone receptor 1.728e-25 0.53
DHB3_HUMAN HSD17B3 Testosterone 17-beta-dehydrogenase 3 1.027e-23 0.35
NK1R_RAT Tacr1 Substance-P receptor 2.488e-19 0.44
GBRG1_RAT Gabrg1 Gamma-aminobutyric acid receptor subunit gamma-1 4.384e-19 0.29
DHB7_HUMAN HSD17B7 3-keto-steroid reductase 1.523e-18 0.29
NMDE3_HUMAN GRIN2C Glutamate receptor ionotropic, NMDA 2C 9.056e-18 0.28
NMDE4_HUMAN GRIN2D Glutamate receptor ionotropic, NMDA 2D 7.438e-15 0.28
PRGR_RAT Pgr Progesterone receptor 3.164e-13 0.29
GABR1_RAT Gabbr1 Gamma-aminobutyric acid type B receptor subunit 1 8.086e-13 0.33
GBRB2_HUMAN GABRB2 Gamma-aminobutyric acid receptor subunit beta-2 1.232e-12 0.32
PRGR_RABIT PGR Progesterone receptor 4.544e-10 0.39
DHB3_RAT Hsd17b3 Testosterone 17-beta-dehydrogenase 3 1.393e-08 0.34
GBRD_HUMAN GABRD Gamma-aminobutyric acid receptor subunit delta 4.633e-08 0.30
AT12A_HUMAN ATP12A Potassium-transporting ATPase alpha chain 2 9.132e-08 0.29
SO1A1_RAT Slco1a1 Solute carrier organic anion transporter family member 1A1 2.041e-07 0.30
NTCP_HUMAN SLC10A1 Sodium/bile acid cotransporter 6.39e-07 0.28
GPBAR_HUMAN GPBAR1 G-protein coupled bile acid receptor 1 7.203e-07 0.39
MCR_RAT Nr3c2 Mineralocorticoid receptor 1.83e-06 0.39
S5A2_RAT Srd5a2 3-oxo-5-alpha-steroid 4-dehydrogenase 2 5.463e-06 0.28

Pixantrone

AMO_PEA Primary amine oxidase 5.821e-52 0.33
KC1D_RABIT CSNK1D Casein kinase I isoform delta 7.497e-47 0.37
KDM6B_HUMAN KDM6B Lysine-specific demethylase 6B 3.21e-19 0.33
3MG_HUMAN MPG DNA-3-methyladenine glycosylase 8.338e-18 0.34
AOC1_HUMAN AOC1 Amiloride-sensitive amine oxidase [copper-containing] 4.189e-17 0.33
Q05BA5_MOUSE Ncoa3 Nuclear receptor coactivator 1.003e-12 0.31
FIBB_HUMAN FGB Fibrinogen beta chain 2.492e-12 0.33
S47A2_HUMAN SLC47A2 Multidrug and toxin extrusion protein 2 8.923e-11 0.34
CAH14_HUMAN CA14 Carbonic anhydrase 14 2.821e-09 0.35
GLF_MYCTU glf UDP-galactopyranose mutase 5.769e-09 0.33
KPCL_HUMAN PRKCH Protein kinase C eta type 5.979e-09 0.42
KS6A3_MOUSE Rps6ka3 Ribosomal protein S6 kinase alpha-3 1.579e-08 0.29
KPCE_HUMAN PRKCE Protein kinase C epsilon type 7.966e-07 0.42
KPCI_HUMAN PRKCI Protein kinase C iota type 1.645e-06 0.33

Tapinarof

O87171_SPHPI lsdA Dioxygenase 4.176e-45 0.28
AHR_RABIT AHR Aryl hydrocarbon receptor 6.314e-41 0.36
NF2L2_HUMAN NFE2L2 Nuclear factor erythroid 2-related factor 2 3.375e-39 0.38
ACH10_HUMAN CHRNA10 Neuronal acetylcholine receptor subunit alpha-10 2.435e-37 0.30
ACHA9_HUMAN CHRNA9 Neuronal acetylcholine receptor subunit alpha-9 2.435e-37 0.30
Q06347_9HIV2 reverse transcriptase Reverse transcriptase 1.332e-36 0.29
MYOC_HUMAN MYOC Myocilin 3.865e-25 0.31
TRPA1_RAT Trpa1 Transient receptor potential cation channel subfamily A member 1 1.994e-21 0.48
TBB1_HUMAN TUBB1 Tubulin beta-1 chain 2.958e-20 0.50
AMD_HUMAN PAM Peptidyl-glycine alpha-amidating monooxygenase 1.347e-19 0.33
PPO1_AGABI PPO1 Polyphenol oxidase 1 3.08e-19 0.33
POL_RSVP gag-pol Gag-Pol polyprotein 2.139e-18 0.29
TF65_HUMAN RELA Transcription factor p65 3.888e-18 0.42
GBRB1_HUMAN GABRB1 Gamma-aminobutyric acid receptor subunit beta-1 5.519e-18 0.34
TTHY_HUMAN TTR Transthyretin 1.602e-17 0.53
FTSZ_ECOLI ftsZ Cell division protein FtsZ 1.882e-17 0.33
CLAT_HUMAN CHAT Choline O-acetyltransferase 3.331e-16 0.32
STXA_SHIDY stxA Shiga toxin subunit A 1.221e-15 0.29
O93874_COCLU 17HSDcl 17beta-hydroxysteroid dehydrogenase 3.922e-13 0.29
ALBU_HUMAN ALB Serum albumin 4.979e-13 0.30
KCNQ2_MOUSE Kcnq2 Potassium voltage-gated channel subfamily KQT member 2 3.722e-12 0.29
DNLI1_HUMAN LIG1 DNA ligase 1 7.334e-12 0.29
DPYD_HUMAN DPYD Dihydropyrimidine dehydrogenase [NADP(+)] 9.7e-12 0.29
A4_HUMAN APP Amyloid-beta precursor protein 1.233e-11 0.39
RBBP9_HUMAN RBBP9 Serine hydrolase RBBP9 4.196e-11 0.30
P2RX1_MOUSE P2rx1 P2X purinoceptor 1 5.054e-11 0.35
CP1B1_HUMAN CYP1B1 Cytochrome P450 1B1 5.515e-11 0.38
LOX5_RAT Alox5 Arachidonate 5-lipoxygenase 1.078e-10 0.45
Q7ZJM1_9HIV1 pol Integrase 5.329e-10 0.35
RNH1_HUMAN RNASEH1 Ribonuclease H1 5.732e-10 0.29
LOX5_HUMAN ALOX5 Arachidonate 5-lipoxygenase 6.415e-10 0.53
G6PT1_HUMAN SLC37A4 Glucose-6-phosphate exchanger SLC37A4 6.557e-10 0.33
LX15B_RAT Alox15b Arachidonate 15-lipoxygenase B 1.206e-09 0.30
NQO2_HUMAN NQO2 Ribosyldihydronicotinamide dehydrogenase [quinone] 5.796e-09 0.38
A0A045ISB3_MYCTX ptbB Phosphotyrosine protein phosphatase 6.704e-09 0.32
Q49PX0_9POXV N1L N1L 1.083e-08 0.31
DOPO_HUMAN DBH Dopamine beta-hydroxylase 1.324e-07 0.28
LDHB_HUMAN LDHB L-lactate dehydrogenase B chain 1.733e-07 0.30
PPO2_AGABI PPO2 Polyphenol oxidase 2 2.702e-07 0.33
NFKB1_HUMAN NFKB1 Nuclear factor NF-kappa-B p105 subunit 2.899e-07 0.29
AK1C4_HUMAN AKR1C4 Aldo-keto reductase family 1 member C4 4.905e-07 0.29
CAH3_BOVIN CA3 Carbonic anhydrase 3 5.631e-07 0.30
AOFB_HUMAN MAOB Amine oxidase [flavin-containing] B 8.248e-07 0.38
TYRO_HUMAN TYR Tyrosinase 1.119e-06 0.32
TLR4_MOUSE Tlr4 Toll-like receptor 4 1.881e-06 0.29
O49150_SOLTU Lipoxygenase 2.044e-06 0.32
ACM5_RAT Chrm5 Muscarinic acetylcholine receptor M5 2.185e-06 0.29
PGH1_HUMAN PTGS1 Prostaglandin G/H synthase 1 2.347e-06 0.36
AK1BA_HUMAN AKR1B10 Aldo-keto reductase family 1 member B10 2.387e-06 0.30
COMT_RAT Comt Catechol O-methyltransferase 3.453e-06 0.31
CAH3_HUMAN CA3 Carbonic anhydrase 3 4.492e-06 0.36
CBPA1_BOVIN CPA1 Carboxypeptidase A1 8.506e-06 0.32
P96830_MYCTO TYR_PHOSPHATASE_2 domain-containing protein 9.349e-06 0.29

Eflornithine

GBRT_HUMAN GABRQ Gamma-aminobutyric acid receptor subunit theta 5.965e-45 0.36
S6A13_RAT Slc6a13 Sodium- and chloride-dependent GABA transporter 2 5.965e-45 0.36
DCOR_RAT Odc1 Ornithine decarboxylase 6.088e-26 0.50
APAH_MYCRA aphA Acetylpolyamine amidohydrolase 5.518e-23 0.28
S6A11_HUMAN SLC6A11 Sodium- and chloride-dependent GABA transporter 3 1.224e-18 0.36
GABR2_RAT Gabbr2 Gamma-aminobutyric acid type B receptor subunit 2 2.797e-18 0.36
GABR1_RAT Gabbr1 Gamma-aminobutyric acid type B receptor subunit 1 1.816e-13 0.36
AMPB_HUMAN RNPEP Aminopeptidase B 2.492e-12 0.33
GBRG1_RAT Gabrg1 Gamma-aminobutyric acid receptor subunit gamma-1 4.108e-12 0.36
PAOX_HUMAN PAOX Peroxisomal N(1)-acetyl-spermine/spermidine oxidase 1.045e-09 0.28
DCOR_HUMAN ODC1 Ornithine decarboxylase 1.241e-08 0.32
S6A11_MOUSE Slc6a11 Sodium- and chloride-dependent GABA transporter 3 1.319e-08 0.36
CBPB1_PIG CPB1 Carboxypeptidase B 1.796e-07 0.31
GABR2_HUMAN GABBR2 Gamma-aminobutyric acid type B receptor subunit 2 2.137e-07 0.36
GABR1_HUMAN GABBR1 Gamma-aminobutyric acid type B receptor subunit 1 3.68e-07 0.36
GBRR1_HUMAN GABRR1 Gamma-aminobutyric acid receptor subunit rho-1 2.176e-06 0.36

Erdosteine

LUXR_ALIFS luxR Transcriptional activator protein LuxR 2.204e-40 0.53
TRAR_RHIRD traR Transcriptional activator protein TraR 2.414e-29 0.55
LASR_PSEAE lasR Transcriptional activator protein LasR 2.376e-14 0.52
Q9RMS5_PSEAI phzR LuxR family transcriptional regulator 2.682e-12 0.50

Pirfenidone

MYH10_HUMAN MYH10 Myosin-10 1.356e-39 0.31
MYH14_MOUSE Myh14 Myosin-14 1.356e-39 0.31
MYH7_PIG MYH7 Myosin-7 1.356e-39 0.31
MYH9_HUMAN MYH9 Myosin-9 1.356e-39 0.31
Q789A4_CHICK MYH10 Nonmuscle myosin heavy chain 1.356e-39 0.31
MYH4_RABIT MYH4 Myosin-4 1.81e-25 0.31
MYS2_DICDI mhcA Myosin-2 heavy chain 1.81e-25 0.31
COMT_HUMAN COMT Catechol O-methyltransferase 6.291e-24 0.35
FCGR1_HUMAN FCGR1A High affinity immunoglobulin gamma Fc receptor I 5.518e-23 0.28
LOXL4_HUMAN LOXL4 Lysyl oxidase homolog 4 1.069e-19 0.38
RGS8_HUMAN RGS8 Regulator of G-protein signaling 8 1.396e-18 0.33
GCN5_YEAST GCN5 Histone acetyltransferase GCN5 9.556e-18 0.35
Q9IP65_HCMV US28 G protein-coupled receptor 3.109e-15 0.29
RGS4_HUMAN RGS4 Regulator of G-protein signaling 4 1.01e-14 0.33
RT109_YEAST RTT109 Histone acetyltransferase RTT109 5.751e-14 0.35
FABH_MYCTU fabH 3-oxoacyl-[acyl-carrier-protein] synthase 3 8.356e-12 0.29
H9B8T9_CAPHI CTSB Cathepsin B 6.116e-11 0.38
US28_HCMVA US28 G-protein coupled receptor homolog US28 8.581e-11 0.29
PHOP1_HUMAN PHOSPHO1 Phosphoethanolamine/phosphocholine phosphatase 9.881e-11 0.33
KPCG_RAT Prkcg Protein kinase C gamma type 1.377e-10 0.36
BRPF3_HUMAN BRPF3 Bromodomain and PHD finger-containing protein 3 1.435e-10 0.33
LOXL3_HUMAN LOXL3 Lysyl oxidase homolog 3 1.642e-10 0.38
A0A060INS8_CAPHI CTSH Cathepsin H 1.977e-10 0.38
HSP12_CAEEL hsp-16.2 Heat shock protein Hsp-16.2 4.884e-10 0.29
MPI_HUMAN MPI Mannose-6-phosphate isomerase 6.542e-10 0.35
BRD1_HUMAN BRD1 Bromodomain-containing protein 1 1.461e-09 0.33
PPOC_ORYSJ PPOX1 Protoporphyrinogen oxidase, chloroplastic 3.781e-09 0.31
BRPF1_HUMAN BRPF1 Peregrin 4.828e-09 0.39
COMT_RAT Comt Catechol O-methyltransferase 8.411e-09 0.30
EP300_HUMAN EP300 Histone acetyltransferase p300 1.215e-08 0.35
O77078_PLAFA fabH Beta-ketoacyl-acyl carrier protein synthase III 1.322e-08 0.29
LYOX_HUMAN LOX Protein-lysine 6-oxidase 1.526e-07 0.38
BRD9_HUMAN BRD9 Bromodomain-containing protein 9 3.214e-07 0.39
GBRB2_HUMAN GABRB2 Gamma-aminobutyric acid receptor subunit beta-2 3.264e-07 0.38
NPY5R_MOUSE Npy5r Neuropeptide Y receptor type 5 3.127e-06 0.35
CATG_HUMAN CTSG Cathepsin G 3.689e-06 0.35
BLA2_BACCE blm Metallo-beta-lactamase type 2 4.4e-06 0.30
SRC_CHICK SRC Proto-oncogene tyrosine-protein kinase Src 5.754e-06 0.35

Teicoplanin

LEP_STAAU spsB Signal peptidase IB 6.561e-39 0.31
LEP_ECOLI lepB Signal peptidase I 7.16e-08 0.31

Arimoclomol

MEP50_HUMAN WDR77 Methylosome protein 50 3.326e-38 0.35
ANM5_HUMAN PRMT5 Protein arginine N-methyltransferase 5 8.086e-38 0.35
FA8_HUMAN F8 Coagulation factor VIII 6.474e-25 0.31
SCN9A_MOUSE Scn9a Sodium channel protein type 9 subunit alpha 2.321e-22 0.30
SCN1A_HUMAN SCN1A Sodium channel protein type 1 subunit alpha 2.332e-22 0.30
MDR1_HUMAN ABCB1 ATP-dependent translocase ABCB1 1.011e-19 0.42
NORA_STAAU norA Quinolone resistance protein NorA 2.666e-06 0.30
CAC1G_HUMAN CACNA1G Voltage-dependent T-type calcium channel subunit alpha-1G 7.447e-06 0.33

Armodafinil

KYNU_RAT Kynu Kynureninase 2.435e-37 0.30
GLT_PYRHO Glutamate transporter homolog 3.875e-36 0.29
CBPA3_HUMAN CPA3 Mast cell carboxypeptidase A 8.661e-35 0.28
BLAB_BACCE Metallo-beta-lactamase type 2 3.865e-33 0.38
CA2D1_MOUSE Cacna2d1 Voltage-dependent calcium channel subunit alpha-2/delta-1 5.731e-29 0.41
KYNU_HUMAN KYNU Kynureninase 7.282e-26 0.30
CACB1_RAT Cacnb1 Voltage-dependent L-type calcium channel subunit beta-1 6.24e-24 0.33
S22A7_RAT Slc22a7 Solute carrier family 22 member 7 2.847e-23 0.29
CA2D1_RAT Cacna2d1 Voltage-dependent calcium channel subunit alpha-2/delta-1 6.53e-22 0.33
NK1R_RAT Tacr1 Substance-P receptor 1.727e-21 0.36
CBPN_HUMAN CPN1 Carboxypeptidase N catalytic chain 4.125e-20 0.33
MANR_PSEPU mdlA Mandelate racemase 9.314e-20 0.31
CAC1B_RAT Cacna1b Voltage-dependent N-type calcium channel subunit alpha-1B 1.11e-16 0.33
EST1_RABIT Liver carboxylesterase 1 1.11e-16 0.36
S15A1_HUMAN SLC15A1 Solute carrier family 15 member 1 1.998e-15 0.29
AOC3_HUMAN AOC3 Membrane primary amine oxidase 2.109e-15 0.33
EAA4_RAT Slc1a6 Excitatory amino acid transporter 4 4.441e-15 0.29
VANX_ENTFC vanX D-alanyl-D-alanine dipeptidase 7.55e-15 0.33
PPAP_HUMAN ACP3 Prostatic acid phosphatase 1.166e-14 0.29
TAAR1_MACMU TAAR1 Trace amine-associated receptor 1 1.166e-14 0.29
CBPB1_PIG CPB1 Carboxypeptidase B 3.32e-14 0.33
S22A6_HUMAN SLC22A6 Solute carrier family 22 member 6 2.592e-13 0.30
ACE_MOUSE Ace Angiotensin-converting enzyme 3.514e-13 0.28
C3AR_HUMAN C3AR1 C3a anaphylatoxin chemotactic receptor 5.826e-13 0.31
BLA2_BACCE blm Metallo-beta-lactamase type 2 7.778e-13 0.38
PAR10_HUMAN PARP10 Protein mono-ADP-ribosyltransferase PARP10 7.94e-13 0.33
CA2D2_RAT Cacna2d2 Voltage-dependent calcium channel subunit alpha-2/delta-2 9.7e-12 0.29
CACB1_HUMAN CACNB1 Voltage-dependent L-type calcium channel subunit beta-1 9.7e-12 0.29
Q79MP6_PSEAI blaIMP-1 Beta-lactamase 1.165e-11 0.31
GRIK3_RAT Grik3 Glutamate receptor ionotropic, kainate 3 1.757e-11 0.36
CBPA1_BOVIN CPA1 Carboxypeptidase A1 3.702e-11 0.33
CAC1A_HUMAN CACNA1A Voltage-dependent P/Q-type calcium channel subunit alpha-1A 1.105e-10 0.29
GP139_HUMAN GPR139 Probable G-protein coupled receptor 139 2.097e-09 0.30
CP51_MYCTU cyp51 Lanosterol 14-alpha demethylase 4.438e-09 0.28
AMD_HUMAN PAM Peptidyl-glycine alpha-amidating monooxygenase 4.608e-09 0.28
EST2_HUMAN CES2 Cocaine esterase 1.016e-08 0.36
A0A072ZLE6_PSEAI mvfR LysR family transcriptional regulator 2.006e-08 0.30
S22A6_RAT Slc22a6 Solute carrier family 22 member 6 1.031e-07 0.29
ACM1_DROME mAChR-A Muscarinic acetylcholine receptor DM1 2.786e-07 0.28
CBPA1_HUMAN CPA1 Carboxypeptidase A1 5.228e-07 0.28
NPFF1_HUMAN NPFFR1 Neuropeptide FF receptor 1 7.467e-07 0.29
NPFF2_HUMAN NPFFR2 Neuropeptide FF receptor 2 9.603e-07 0.29
GABR1_RAT Gabbr1 Gamma-aminobutyric acid type B receptor subunit 1 1.211e-06 0.32
EST1_HUMAN CES1 Liver carboxylesterase 1 1.238e-06 0.36
AMPN_PIG ANPEP Aminopeptidase N 2.334e-06 0.34
GRM3_HUMAN GRM3 Metabotropic glutamate receptor 3 4.275e-06 0.36
5HT2A_RAT Htr2a 5-hydroxytryptamine receptor 2A 6.967e-06 0.35
NALD2_HUMAN NAALAD2 N-acetylated-alpha-linked acidic dipeptidase 2 8.09e-06 0.28
SYYC_HUMAN YARS1 Tyrosine--tRNA ligase, cytoplasmic 8.364e-06 0.29

Methsuximide

ADA1B_MOUSE Adra1b Alpha-1B adrenergic receptor 5.246e-35 0.35
Q9IP65_HCMV US28 G protein-coupled receptor 6.279e-30 0.30
PPME1_HUMAN PPME1 Protein phosphatase methylesterase 1 6.243e-24 0.29
FSHR_RAT Fshr Follicle-stimulating hormone receptor 4.377e-23 0.28
US28_HCMVA US28 G-protein coupled receptor homolog US28 5.518e-21 0.30
TSHB_BOVIN TSHB Thyrotropin subunit beta 5.19e-19 0.30
FSHR_HUMAN FSHR Follicle-stimulating hormone receptor 1.865e-10 0.32
SC6A4_MOUSE Slc6a4 Sodium-dependent serotonin transporter 2.322e-10 0.29
HPPD_ARATH HPD 4-hydroxyphenylpyruvate dioxygenase 5.42e-09 0.28
BACE1_HUMAN BACE1 Beta-secretase 1 2.212e-08 0.51
SC6A2_MOUSE Slc6a2 Sodium-dependent noradrenaline transporter 3.709e-08 0.29
BACE2_HUMAN BACE2 Beta-secretase 2 3.758e-07 0.41
PLM2_PLAFA Plasmepsin-2 3.388e-06 0.34
ADA1D_RAT Adra1d Alpha-1D adrenergic receptor 3.916e-06 0.35

Silver_sulfadiazine

Q5TU56_ANOGA 1272966 Carbonic anhydrase 1.123e-28 0.42
Q5U9J1_THAWE ca1 Delta carbonic anhydrase 4.693e-22 0.42
Q9HVB9_PSEAE Carbonic anhydrase 6.654e-21 0.33
CAH_METTE Carbonic anhydrase 9.987e-20 0.42
C0IX24_STYPI CA2 Carbonic anhydrase 6.821e-18 0.42
B2V8E3_SULSY Carbonate dehydratase 3.227e-17 0.42
B5SU02_STYPI CA Alpha carbonic anhydrase 3.227e-17 0.42
Q31FD6_HYDCU Carbonic anhydrase, alpha family 3.227e-17 0.42
CAH1_HORSE CA1 Carbonic anhydrase 1 1.11e-16 0.30
A6YCJ1_9METZ Astrosclerin-3 2.22e-16 0.42
CYNT_HELPY cynT Carbonic anhydrase 7.772e-15 0.42
MTCA2_MYCTU mtcA2 Carbonic anhydrase 2 1.277e-14 0.33
CAH13_MOUSE Ca13 Carbonic anhydrase 13 4.742e-13 0.42
CAN_YEAST NCE103 Carbonic anhydrase 4.875e-13 0.33
Q3I4V7_CRYNV CAN2 Carbonic anhydrase 1.982e-11 0.42
MTCA1_MYCTU mtcA1 Beta-carbonic anhydrase 1 9.362e-11 0.42
CAH15_MOUSE Ca15 Carbonic anhydrase 15 2.441e-10 0.42
CAH6_HUMAN CA6 Carbonic anhydrase 6 2.939e-10 0.42
CP51_MYCTU cyp51 Lanosterol 14-alpha demethylase 4.323e-10 0.32
Q6FTL6_CANGA NCE103 Carbonic anhydrase 6e-10 0.42
PADI1_HUMAN PADI1 Protein-arginine deiminase type-1 7.541e-10 0.29
PADI2_HUMAN PADI2 Protein-arginine deiminase type-2 7.541e-10 0.29
PADI3_HUMAN PADI3 Protein-arginine deiminase type-3 7.541e-10 0.29
P96878_MYCTU Probable transmembrane carbonic anhydrase (Carbonate dehydratase) (Carbonic dehydratase) 9.875e-10 0.42
PHLP2_HUMAN PHLPP2 PH domain leucine-rich repeat-containing protein phosphatase 2 2.487e-08 0.31
5NTD_HUMAN NT5E 5'-nucleotidase 2.593e-08 0.41
METC_ECOLI metC Cystathionine beta-lyase MetC 6.126e-08 0.31
CAN_CANAL NCE103 Carbonic anhydrase 3.311e-07 0.42
PADI4_HUMAN PADI4 Protein-arginine deiminase type-4 9.396e-07 0.29
CAH9_HUMAN CA9 Carbonic anhydrase 9 2.237e-06 0.42
CAH12_HUMAN CA12 Carbonic anhydrase 12 2.971e-06 0.42
CAH14_HUMAN CA14 Carbonic anhydrase 14 7.092e-06 0.42
CAH5B_HUMAN CA5B Carbonic anhydrase 5B, mitochondrial 9.631e-06 0.42

Dexlansoprazole

ENASE_HUMAN ENGASE Cytosolic endo-beta-N-acetylglucosaminidase 8.667e-28 0.45
THIO_HUMAN TXN Thioredoxin 1.776e-15 0.29
ALKB3_HUMAN ALKBH3 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 5.662e-15 0.32
ATP4A_PIG ATP4A Potassium-transporting ATPase alpha chain 1 2.645e-13 0.38
PEBB_HUMAN CBFB Core-binding factor subunit beta 4.122e-08 0.29
UPAR_HUMAN PLAUR Urokinase plasminogen activator surface receptor 6.322e-07 0.28
CYSP_TRYCR Cruzipain 6.026e-06 0.33

Gallium_nitrate

G3P_RABIT GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1.318e-21 0.42
MURA_ECOLI murA UDP-N-acetylglucosamine 1-carboxyvinyltransferase 4.197e-14 0.38

Cenobamate

OPRX_HUMAN OPRL1 Nociceptin receptor 9.298e-18 0.34
CISY2_YEAST CIT2 Citrate synthase, peroxisomal 6.322e-07 0.28
OPRM_HUMAN OPRM1 Mu-type opioid receptor 2.163e-06 0.34
LPAR1_HUMAN LPAR1 Lysophosphatidic acid receptor 1 3.52e-06 0.34
PPGB_HUMAN CTSA Lysosomal protective protein 9.769e-06 0.30

Samarium_(153Sm)_lexidronam

AROA_ECOLI aroA 3-phosphoshikimate 1-carboxyvinyltransferase 3.969e-17 0.37
B1LRJ1_ECOSM traI Type IV secretion-like conjugative transfer relaxase protein TraI 2.22e-15 0.29

Pentaerythritol_tetranitrate

MURA_ECOLI murA UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1.105e-10 0.29

Pretomanid

ANM6_HUMAN PRMT6 Protein arginine N-methyltransferase 6 8.358e-10 0.39
KCNJ2_MOUSE Kcnj2 Inward rectifier potassium channel 2 7.319e-09 0.30
CARM1_HUMAN CARM1 Histone-arginine methyltransferase CARM1 3.395e-08 0.39

Crisaborole

SCN9A_HUMAN SCN9A Sodium channel protein type 9 subunit alpha 2.884e-09 0.36
Q8I5C5_PLAF7 Macrophage migration inhibitory factor 2.049e-06 0.29

Brivaracetam

O77773_PIG Voltage-dependent calcium channel alpha-2 delta subunit 1.181e-07 0.30
Q6MGC4_RAT Pfdn6 H2-K region expressed gene 2, rat orthologue 7.451e-06 0.30